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Background: The Dietary diabetes risk reduction score (DDRRS) has recently been considered by researchers as a diet quality index to predict the risk of chronic diseases, such as type 2 diabetes (T2D). In this study, we aimed to assess the association of DDRRS with T2D risk in Iranian adults. Methods: Subjects aged ≥ 40 years without T2D (n = 2081) were selected for the current study from participants of the Tehran Lipid and Glucose Study (2009–2011) and followed for a mean of 6.01 years. We used the food frequency questionnaire to determine the DDRRS that is characterized by eight components, including higher consumption of nuts, cereal fiber, coffee, and polyunsaturated to saturated fat ratio and lower consumption of red or processed meats, trans fats, sugar-sweetened beverages, and high glycemic index foods. The multivariable logistic regression analysis was used to determine the odds ratio (ORs) and 95% confidence interval (CI) of T2D across the DDRRS tertiles. Results: The mean ± SD age of individuals was 50.4 ± 8.2 years at baseline. The Median (25–75 interquartile range) DDRRS of the study population was 24(22–27). During the study follow-up, 233(11.2%) new cases of T2D were ascertained. In the age and sex-adjusted model, the odds of T2D were decreased across tertiles of DDRRS (OR = 0.68; 95%CI: 0.48–0.97, P for trend = 0.037). Based on the multivariable-adjusted model, after controlling all potential confounders, the risk of T2D is reduced across tertiles of DDRRS (OR = 0.66; 95%CI: 0.44–0.98, P for trend = 0.047). Also, higher scores (lower consumption) of red and processed meat (OR = 0.59; 95%CI: 0.39–0.88, P = 0.012) and sugar-sweetened beverages (OR = 0.49; 95%CI: 0.32–0.76, P = 0.002) as DDRRS components were associated with decreased T2D incident. Conclusions: Our findings suggested that a diet with a higher score of DDRRS may be related to reducing the risk of T2D in Iranian adults. [ABSTRACT FROM AUTHOR]

Background: The aim of the present study was to examine the association between hemoglobin A1C (HbA1C( and eGFR in patients with type 2 diabetes (T2D). Methods: This cross-sectional study was conducted on 802 patients with T2D visiting Abu Reyhan Clinic of Shahid Mohammadi Hospital in Bandar Abbas, Iran. eGFR was determined using MDRD and EPI methods. The association between two levels of HbA1C (≤8% and >8%) and two levels of GFR (≤60% and >60%) were assessed in total population, and separately, in men and women using linear regression model. Results: The mean ± SD age of the study population (27.7% male) was 53.5 ± 5.5 years. Based on the multivariable adjusted model, in subjects with HbA1C >8%, there was a negative association between HbA1C and eGFR-EPI (β = -0.14) and eGFR-MDRD (β = - 0.12), (P<0.05). However, there was no significant relationship between HbA1C and eGFR in individuals with HbA1C ≤8%. Also, no significant association was found between HbA1C and eGFR as categorical variables (based on the two categories of eGFR ≤60 and >60). An inverse association was observed between GFR ≤60 and HbA1C >8% in women based on the Hb classification. This inverse association was found between HbA1C >8% and eGFREPI (β = -0.76) and eGFR-MDRD (β = -0.78) in women with Hb >12 mg/dl (P<0.01). Conclusion: According to the results, the higher level of HbA1C can be associated with decreased eGFR level. This negative association was mostly observed between HbA1C >8% and GFR ≤60 in T2DM female patients without anemia (Hb>12). It seems that monitoring kidney function by eGFR estimation is a necessary action in patients with T2D with high HbA1C levels. [ABSTRACT FROM AUTHOR]

The high risk of lipid abnormalities in type 2 diabetic (T2D) patients with uncontrolled hyperglycemia may be associated with an increased risk of cardiovascular complications. The aim of the current study was to investigate the association between glycated hemoglobin)HbA1c(and lipid profile levels in T2D patients. This cross-sectional study was conducted on 802 T2D patients, aged= 40 years, visiting the Abu Reyhan Clinic of Shahid Mohammadi Hospital in Bandar Abbas, Iran. Serum lipid profiles were measured by the enzymatic method. Diabetes was defined based on the criteria of the American Diabetes Association. The association of HbA1c and estimated glomeruli filtration rate (eGFR) with lipid profile indices was assessed using the Spearman correlation coefficient test and linear regression model. The mean±SD age of participants (27.7% of men) was 53.55±5.56 years. The mean±SD of HbA1c and eGFR for all subjects were 8.97±2.14 and 86.30±17.48, respectively. In this study, a positive association was observed between HbA1c and fasting blood glucose (r=0.619, ß=0.635), total cholesterol (r=0.165, ß=0.188), triglycerides (r=0.103, ß=0.095), and low-density lipoprotein cholesterol (r=0.162, ß=0.173), (P<0.01). Also, an inverse association has been observed between eGFR level and TGs (r=-0.08, ß=-0.096) and FBS (r=- 0.123, ß=-0.172), (P<0.05). Our findings suggested that HbA1c is not only an applicable predictor of longterm glycaemic control but also can be considered as a potential biomarker for predicting lipid abnormalities in T2D patients. [ABSTRACT FROM AUTHOR]

As a rare and normally-benign and functionless tumor, primary adrenal myelolipoma comprises adipose tissue and myeloid cells, and its diagnosis is usually difficult owing to its asymptomatic nature. Imaging techniques can detect these masses in over 90% of the cases. CT scan is the most sensitive imaging technique, which can display the tissue nature of this tumor with a high resolution. The present case report involves a 45-year-old woman with bilateral adrenal myelolipoma diagnosed with imaging methods. [ABSTRACT FROM AUTHOR]

Introduction. The ankle-brachial index (ABI), measurement of carotid artery intima-media thickness (CIMT), and assessment of the thickness of interventricular septum (IVS), are noninvasive methods used to predict subclinical atherosclerosis in hemodialysis patients. This study aimed to determine the prevalence of peripheral arterial disease and to assess the correlations between ABI, CIMT, the thickness of IVS, and blood parameters in hemodialysis patients. Materials and Methods. The ABI, CIMT, and the thickness of IVS were measured in 50 patients on hemodialysis. Data were collected regarding the levels of calcium, urine nitrogen, lowdensity lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, cholesterol, creatinine, albumin in serum, as well as erythrocyte sedimentation rate. Results. Ten percent of the patients showed a reduced ABI (< 0.9). The mean values for ABI, CIMT, and IVS were 1.09 ± 0.13, 0.68 ± 0.11mm, and 9.83 ± 1.65 mm, respectively. The levels of calcium, cholesterol, low-density lipoprotein cholesterol, highdensity lipoprotein cholesterol, and triglyceride in the serum of the patients with normal ABI were significantly higher than in patients with reduced ABI. There was a negative correlation between ABI and levels of serum LDLC (r = -0.29, P = .04) and triglyceride (r = -0.32, P = .02). Conclusions. The prevalence of peripheral arterial disease in the patients with CRF was 10% and it was correlated with several classical risk factors for atherosclerosis, including elevated LDL and cholesterol levels. CIMT and the thickness of IVS showed no apparent association with ABI. [ABSTRACT FROM AUTHOR]

Background: To better manage the COVID-19 pandemic, it is necessary to carefully study information about patients with COVID-19. Objective: To report clinical and epidemiological characteristics of COVID-19 patients in southern Iran. Methods: This cross-sectional retrospective study was conducted based on data extracted from the COVID-19 registry of Hormozgan. Data from patients with confirmed COVID-19 based on CT-scan results or real-time reverse transcriptase-polymerase chain reaction (RT-PCR) results until September 25, 2020, were analyzed for this study (2351 inpatients). We reported demographics, signs and symptoms on admission, comorbidities, and treatments, as well as clinical outcomes, hospital stay, and intensive care unit (ICU) admission. Results: Most of patients were men (1235/2351; 52.5%) and the most common signs and symptoms included cough (1343/2351; 57.1%), shortness of breath (1224/2351; 52.1%) and fever. The most common comorbidities included hypertension (410/2351 (17.4%), diabetes (343/2351; 14.6%) and chronic cardiac disease (282/2351; 12%). Also, 228 patients (9.7%) were hospitalized in the ICU. The mortality rate was 12.5% (295/2351) among all patients and 64.5% (147/228) in ICU wards, respectively. The number of cases with comorbidities including hypertension, chronic cardiac disease, diabetes, chronic neurological disorders, chronic kidney disease, chronic hematologic disease, malignant neoplasm, moderate or severe liver disease, dementia and fauvism in the ICU was significantly higher than the general wards. Conclusion: Most characteristics of our patients were similar to those reported in other studies; however, our patients were younger and suffered from a less severe disease. The mortality rate in the ICU was higher than other studies. [ABSTRACT FROM AUTHOR]

Introduction: Dyslipidemia is a common metabolic abnormality in Type 2 diabetic Mellitus (T2DM) patients with kidney dysfunction. Therefore, the current study was conducted to assess the association between serum lipid levels and estimated glomerular filtration rate (eGFR) in T2DM patients.Methods: This cross-sectional study was performed on 802 participants, aged 40 years or more who had referred to the Abu Reyhan Clinic of Shahid Mohammadi Hospital in Bandar Abbas, Hormozgan province, Iran. Biochemical variables including FBS, triglycerides, total cholestrol, LDL-C, and HDL-C levels were measured using the enzymatic method. The association between serum lipid profile and eGFR was assessed using the Spearman correlation coefficient test and linear regression model.Results: Mean ± SD age of the subjects (72.3% females) was 53.55 ± 5.56 years old. Mean ± SD of eGFR-EPI and eGFR-MDRD was 86.30 ± 17.48 and 86.80 ± 23.29, respectively for all the subjects. In the current study, a negative association was observed between eGFR-EPI and FBS (r = -0.123, β = -0.172) and TGs (r = -0.080, β = -0.096) (P < .01). Also, there was an inverse association between the eGFR-MDRD and FBS (r = -0.123, β = -0.172) and TGs levels (r = -0.074, β = -0.086) (P < .05). However, the concentration of other lipid profiles was not associated with the eGFR level (estimated by EPI and MDRD methods).Conclusion: Our findings suggested that the patients with reduced eGFR level are more likely to have greater TG serum level. Therefore, high TG levels can be considered as a potential biomarker for predicting renal complications in the patients with T2DM. [ABSTRACT FROM AUTHOR]

A letter to the editor in response to the article "Blood Procalcitonin Predicts Spontaneous Bacterial Peritonitis in Patients with Cirrhosis and Ascites," that was published in a previous issue of the journal is presented.