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Adenoid Cystic Carcinoma (ACC) is an uncommon form of malignant neoplasm of the salivary gland. ACC is a rare epithelial, slowgrowing yet aggressive neoplasm with a remarkable capacity for recurrence. It most commonly develops in the salivary glands or other regions of the head and neck. Hereby, authors present a case of a 72-year-old female who presented with a rapidly enlarging swelling in the right submandibular region, which had recurred three times. Histopathological examination reported it as ACC grade II. ACC is known for its ability to invade perineurally, its high frequency of local and distant recurrence and its poor long-term prognosis. In the present case, the treatment provided was complete surgical resection. The patient underwent wide surgical excision of the lesion with appropriate margins, as well as a completion neck dissection of level IA. The histopathological diagnosis is based on tissue examination findings that exhibit typical histologic features. The presence and percentage of solid architecture reflect clinical outcomes and should be reported in the pathology report. Current diagnostics mainly rely on histomorphology, along with immunohistochemistry and cytogenetics. Poor prognostic factors include large tumour size, solid growth pattern, positive surgical margins, nodal status, nuclear atypia, high mitotic activity, high-grade transformation, lymphovascular invasion and tumour necrosis. The patient was kept on regular follow-up and there was no recurrence or metastasis noted over two years. ACC remains extremely difficult to treat due to its high recurrence and metastasis rates. The authors are presenting a case of right submandibular gland ACC for its rarity, multiple recurrences, aggressive clinical behaviour and associated radiological and histopathological findings. [ABSTRACT FROM AUTHOR]

The Dalbergia sissoo leaves traditionally have medicinal values and are well known for current research on osteoporosis and bone health. The present research aims to develop and validate a simple, sensitive, and comprehensive analytical method to standardize Dalbergia sissoo leaves. An ultra‐high performance liquid chromatography method was developed for seven isoflavone glycosides, and isoflavone's identification, including bioactive caviunin and biochanin‐A based glycosides with genistein, pratensein, biochanin‐A, and biochanin‐A‐7‐O‐glucoside for simultaneous quantification in Dalbergia sissoo leaves. Also, a novel high‐performance thin‐layer chromatography‐based method has been developed for isoflavone glycosides as a visual quality control tool for Dalbergia sissoo. Further, seven isoflavonoids were also characterized using mass spectrometry in sample matrices. A qualitative high‐performance thin‐layer chromatography‐based method was found helpful in identifying four major isoflavone glycosides in leaves. The performance of the method and the validation data showed the ultra‐high performance liquid chromatography method was precise (relative standard deviation < 5.0%), accurate (recoveries 80%–110%), robust (relative standard deviation < 5.0%), and linear (r2 > 0.99) for quantification. This well‐separated novel and rapid determination of Dalbergia sissoo compounds in leaves will be helpful in the standardization of the quality assessment tool for Dalbergia sissoo. [ABSTRACT FROM AUTHOR]

Endometriod adenocarcinoma at the fallopian tube is extremely rare histopathological variant of fallopian tube cancer. A 42 year postmenopausal women presenting with lower abdominal pain and bleeding. Radioimaging showed left adnexal neoplastic mass lesion. Panhysterectomy specimen on histopathology reported as endometroid adenocarcinoma of left fallopian tube with high grade stage IB as per FIGO system. We are presenting this case for its extreme rarity, clinical and histopathological findings. [ABSTRACT FROM AUTHOR]