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619 results on '"Jagannathan N"'

5. A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells

Author

Sin, Wei-Xiang, primary, Jagannathan, N. Suhas, additional, Teo, Denise Bei Lin, additional, Kairi, Faris, additional, Fong, Shin Yie, additional, Tan, Joel Heng Loong, additional, Sandikin, Dedy, additional, Cheung, Ka-Wai, additional, Luah, Yen Hoon, additional, Wu, Xiaolin, additional, Raymond, Joshua Jebaraj, additional, Lim, Francesca Lorraine Wei Inng, additional, Lee, Yie Hou, additional, Seng, Michaela Su-Fern, additional, Soh, Shui Yen, additional, Chen, Qingfeng, additional, Ram, Rajeev J., additional, Tucker-Kellogg, Lisa, additional, and Birnbaum, Michael E., additional

Published
2024
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7. Multi-omic analysis of bat versus human fibroblasts reveals altered central metabolism.

Author

Jagannathan, N. Suhas, Yu Peng Koh, Javier, Younghwan Lee, Sobota, Radoslaw Mikolaj, Irving, Aaron T., Lin-fa Wang, Yoko Itahana, Koji Itahana, and Tucker-Kellogg, Lisa

Subjects
*TRANSMISSIBLE tumors, *REACTIVE oxygen species, *SIMULIIDAE, *ELECTRON transport, *METABOLIC regulation
Abstract

Bats have unique characteristics compared to other mammals, including increased longevity and higher resistance to cancer and infectious disease. While previous studies have analyzed the metabolic requirements for flight, it is still unclear how bat metabolism supports these unique features, and no study has integrated metabolomics, transcriptomics, and proteomics to characterize bat metabolism. In this work, we performed a multi-omics data analysis using a computational model of metabolic fluxes to identify fundamental differences in central metabolism between primary lung fibroblast cell lines from the black flying fox fruit bat (Pteropus alecto) and human. Bat cells showed higher expression levels of Complex I components of electron transport chain (ETC), but, remarkably, a lower rate of oxygen consumption. Computational modeling interpreted these results as indicating that Complex II activity may be low or reversed, similar to an ischemic state. An ischemic-like state of bats was also supported by decreased levels of central metabolites and increased ratios of succinate to fumarate in bat cells. Ischemic states tend to produce reactive oxygen species (ROS), which would be incompatible with the longevity of bats. However, bat cells had higher antioxidant reservoirs (higher total glutathione and higher ratio of NADPH to NADP) despite higher mitochondrial ROS levels. In addition, bat cells were more resistant to glucose deprivation and had increased resistance to ferroptosis, one of the characteristics of which is oxidative stress. Thus, our studies revealed distinct differences in the ETC regulation and metabolic stress responses between human and bat cells. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Association of cognitive impairment with sleep quality, depression and cardiometabolic risk factors in individuals with type 2 diabetes mellitus: A cross sectional study

Author

Gupta, Anu, Gupta, Yashdeep, Anjana, Ranjit Mohan, Ranjani, H., Kalaivani, Mani, Goyal, Alpesh, Jagannathan, N., Sharma, Sandhya, Mittal, Bhavika, Radhakrishnan, Vinoth Kumar, Garg, Vineeta, Sharma, Gautam, Jyotsna, Viveka P., Sagar, Rajesh, Mohan, Viswanathan, and Tandon, Nikhil

Published
2021
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19. Experimental, Analytical, and Computational Studies on the Fatigue Crack Growth Behavior of a Titanium Alloy under Cold-Turbistan Spectrum Loads.

Author

Manjunatha, C. M., Malipatil, Sharanagouda G., Nagarajappa, N., Majila, Anuradha N., Fernando, D. Chandru, Bojja, Ramesh, Jagannathan, N., and Manjuprasad, M.

Abstract

The fatigue crack growth (FCG) behavior of Ti-6Al-4V alloy subjected to spectrum loads was experimentally determined and compared with predicted behavior by analytical and computational methods. In the experimental method, a compact tension (CT) specimen of Ti-6Al-4V was tested under standard cold-Turbistan spectrum loads to determine crack propagation behavior. Spectrum fatigue tests were conducted with triangular waveform at 2 Hz. In the analytical predictive method firstly, constant amplitude FCG tests were conducted at several stress ratios and a unified FCG law based on crack driving force, K* was derived for Ti-6Al-4V alloy. Then, the crack growth for every rainflow-counted fatigue load cycle in the cold-Turbistan sequence was determined using the derived FCG law. In the computational method, a global and a local model of the CT specimen of Ti-6Al-4V were created in HYPERMESH and FRANC3D, respectively. The FCG behavior under the cold-Turbistan spectrum was then predicted using FRANC3D and MSC NASTRAN. The required materials constants for the FCG law in the FRANC3D software were derived from the experimental constant amplitude FCG rate data of Ti-6Al-4V alloy. It was observed that both methods of FCG predictions, i.e., analytical and computational methods, although conservative, compared quite well with experimental results. [ABSTRACT FROM AUTHOR]

Published
2024
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30. The efficacy of GlideScope® videolaryngoscopy compared with direct laryngoscopy in children who are difficult to intubate: an analysis from the paediatric difficult intubation registry

Author

Park, R, Peyton, J M, Fiadjoe, J E, Hunyady, A I, Kimball, T, Zurakowski, D, Kovatsis, P G, Bosenberg, A, Hopkins, P, Glover, C, Olutoye, O, Szmuk, P, Olomu, P, Jagannathan, N, Burjek, N, Watkins, S, Reynolds, P, Haydar, B, Matuszczak, M, Jain, R, Khalil, S, Polaner, D, Zieg, J, Szolnoki, J, Sathyamoorthy, M, Taicher, B, Bhattacharya, S, Raman, V, Bhalla, T, Stricker, P, Lockman, J, Galvez, J, Rehman, MDM, Nishisaki, A, von Ungern-Sternberg, B, Sommerfield, D, Soneru, C, Chiao, F, Richtsfeld, M, Belani, K, Sarmiento, L, Mireles, S, and Rosas, G B

Published
2017
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49. sj-docx-1-dhj-10.1177_20552076211039032 - Supplemental material for Change in cardiometabolic risk factors among Asian Indian adults recruited in a mHealth-based diabetes prevention trial

Author

Muralidharan, Shruti, Ranjani, Harish, Anjana, Ranjit Mohan, Gupta, Yashdeep, Ambekar, Samita, Koppikar, Varsha, Jagannathan, N, Jena, Sidhant, Tandon, Nikhil, Allender, Steven, and Mohan, Viswanathan

Subjects
FOS: Computer and information sciences, 200299 Cultural Studies not elsewhere classified, Science Policy, FOS: Clinical medicine, FOS: Political science, 150310 Organisation and Management Theory, Cardiology, 111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences, 110306 Endocrinology, 110308 Geriatrics and Gerontology, 99999 Engineering not elsewhere classified, FOS: Sociology, FOS: Economics and business, 111099 Nursing not elsewhere classified, FOS: Other engineering and technologies, Sociology, 111708 Health and Community Services, Anthropology, 111702 Aged Health Care, 89999 Information and Computing Sciences not elsewhere classified, FOS: Other humanities, 160512 Social Policy, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-1-dhj-10.1177_20552076211039032 for Change in cardiometabolic risk factors among Asian Indian adults recruited in a mHealth-based diabetes prevention trial by Shruti Muralidharan, Harish Ranjani, Ranjit Mohan Anjana, Yashdeep Gupta, Samita Ambekar, Varsha Koppikar, N Jagannathan, Sidhant Jena, Nikhil Tandon, Steven Allender and Viswanathan Mohan in Digital Health

Published
2021
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