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19 results on '"Jag Dhanda"'

1. Facial Nerve Revascularization Strategies in Facial Restoration

Author

Ankur Khajuria, MRCS, PhD, Brian Bisase, FRCS, Paul Norris, FRCS, Jag Dhanda, FRCS, PhD, Isao Koshima, MD, PhD, Charles Nduka, MD, FRCS, and Ruben Y. Kannan, FRCS, PhD

Subjects
Surgery, RD1-811
Abstract

Background:. Facial transplants represent the current exemplar in the reconstruction of severely damaged faces, whereas conventional free flap reconstruction has its limitations in restoring both function and surface cover. Methods:. In a retrospective study over 6 years (2014–2020), 5 cases (n = 5) of vascularized nerve flaps (VNFs) were performed by our team. These involved three acute and two late reconstructions. The mean age was 41 years with a maximum of 6-year follow-up. To objectify the different permutations and combinations, we categorized composite, chimeric, and hybrid VNFs into types I, IIa-c, and III, each with a unique characteristic. Postoperative function was evaluated using the validated Sunnybrook and Terzis scores for facial nerve palsy; masticatory function was assessed using dental impression studies. Results:. There was a 100% flap survival rate, with no instances of flap necrosis and only one complication: hematoma at 24 hours postoperative. Sunnybrook and Terzis scores showed a statistically significant improvement postoperatively, indicating both improved repose and facial expressions (paired student t test, P < 0.05). Given that each VNF was specifically customized for a particular patient, each type of VNF in this cohort was unique, thereby illustrating each type succinctly. Conclusions:. VNFs are separate entities from standard free flaps, as they require extensive preoperative planning to allow the deconstructing of composite blocks of tissue into separate vascularized entities and amalgamating them into a new conglomerate. This allows VNFs to fill a niche area in facial reconstructive surgery between face transplants and conventional free tissue transfers, with enormous potential.

Published
2022
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5. Perineural and lymphovascular invasion in squamous cell carcinoma of the tongue

Author

Murray K Pratt, Aakshay Gulati, Laurence Newman, Paul Norris, John V. Tighe, A.W. Barrett, Isabel Sassoon, Jag Dhanda, and Brian Bisase

Subjects
CD31, Cancer Research, medicine.medical_specialty, Lymphovascular invasion, medicine.medical_treatment, Perineural invasion, Gastroenterology, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Tongue, Internal medicine, medicine, Humans, Neoplasm Invasiveness, Tongue Neoplasm, Stage (cooking), Retrospective Studies, business.industry, Neck dissection, 030206 dentistry, Prognosis, Tongue Neoplasms, medicine.anatomical_structure, Otorhinolaryngology, 030220 oncology & carcinogenesis, Lymphatic Metastasis, Carcinoma, Squamous Cell, Periodontics, Immunohistochemistry, Oral Surgery, business
Abstract

BACKGROUND Perineural invasion (PNI) and lymphovascular invasion (LVI) may be adverse prognostic indicators in squamous cell carcinoma (SCC) of the tongue. METHODS The percentages of histological PNI and LVI were determined in 335 patients with tongue SCC. Sixty tumours originally reported as negative for these features were tested to determine how many more were positive with "immunohistochemical enhancement." RESULTS PNI was found in 141 (42.1%) and LVI in 51 (15.2%) patients. 79.4% of the 141 patients who had PNI and 72.6% of the 51 with LVI had a T3 or T4 tumour. Lymph node metastasis was identified in 145 (51.2%) of the 280 patients who had undergone neck dissection; 58.2% of the 141 patients with PNI and 80.4% of the 51 patients with LVI had lymph node metastasis. There was a highly statistically significant correlation between PNI with increasing pT (P

Published
2020

6. List of Contributors

Author

Khalild Abdel-Galil, Abdul Ahmed, Nabeela Ahmed, Thomas Aldridge, Kavin Andi, Bilal Al-Nawas, Eric Arnaud, Christopher M.E. Avery, Mark Bainbridge, Victoria Beale, William H. Bell, Natasha Louise Berridge, Adam Blancher, Michael S. Block, John N St. J Blythe, Jens Bodem, Paolo Boffano, Farzad Borumandi, Rudolf Robert Maria Bos, Major John Breeze, Peter A. Brennan, James Brown, Rudolf F. Buntic, Heinz Bürger, Brady Burton, Eric R. Carlson, Luke Cascarini, Siwan Cassidy, Alison Chalmers, David Chapireau, Alistair R.M. Cobb, Serryth Colbert, Margaret Jean Coyle, Angelo Cuzalina, Jason E. Dashow, Jag Dhanda, David Drake, Alex D. Ehrlich, Simon Ellis, T. William Evans, Helen Extence, Shahme Ahamed Farook, Jerry N. Farrier, Adekunmi Fasanmade, Rui P. Fernandes, Tim Forouzanfar, Tobias Fretwurst, David E. Frost, Alexander Johann Gaggl Sr., Rishi Kumar Gandhi, Nils-Claudius Bernhard Gellrich, Katherine George, G.E. Ghali, Michael Gilhooly, Daryl R. Godden, Marianela Gonzalez, Jonathan B. Gottlieb, Henry A. Alan Gremillion, Ben C. Green, Elizabeth Anne Gruber, Cesar A. Guerrero, Rishi Jay Gupta, Kevin J. Harrington, Christopher Harris, Andrea M. Hebert, Joseph Helman, Jürgen Hoffmann, Bodo Hoffmeister, Simon Holmes, Dominik Horn, Birgit Jaspers, Gernot Jundt, Julian Eamon Kabala, Leonard B. Kaban, Arshad Kaleem, Anastasios Kanatas, Charles Gerald Kelly, Gary D. Klasser, Beomjune B. Kim, David A. Koppel, Norbert R. Kübler, Ilya Likhterov, Timothy William Lloyd, Richard A. Loukota, Joshua E. Lubek, Andrew Lyons, Col. Neil Mackenzie, Gitta Madani, Michael R. Markiewicz, Nigel Shaun Matthews, Joe McQuillan, Mark McGurk, Divya Mehrotra, Nigel Stuart George Mercer, Louis Gerard Mercuri, Ashraf Messiha, Florencio Monje, Elena V. Mujica, Rachel Anne Mumford, Kenlchiro Murakami, Friedemann Nauck, Hendrik Naujokat, Friedrich-Wilhelm Neukam, Suzan Obagi, Robert A. Ord, Yirae Ort, Ravinder Pabla, Bonnie L. Padwa, Stavan Patel, Chris Neil Penfold, Jon D. Perenack, Michael P. Powers, Wolfgang Puelacher, Faisal A. Quereshy, Jan D. Raguse, Sujeev Rajapakse, Parkash L. Ramchandani, Cory M. Resnick, Janet Mary Risk, Stephen N. Robinson, Eduardo D. Rodriguez, Simon N. Rogers, J.L.N. Roodenburg, Nadeem Saeed, Andrew Graeme Schache, Stephen A. Schendel, Henning Schliephake, Rainer Schmelzeisen, Andrea Maria Schmidt-Westhausen, Riitta Seppänen-Kaijansinkko, Richard J. Shaw, Andrew J. Sidebottom, Mark K. Singh, Rabindra P. Singh, Douglas P. Sinn, Ludi E. Smeele, C. Blake Smith, Brian Sommerlad, Frank Peter Strietzel, Adrian Sugar, Anita Takwale, Clark O. Taylor, William Arthur Townley, Timothy A. Turvey, Mark L. Urken, Simon Van Eeden, Wilfried Wagner, Peter C. Whitfield, Michael J. Will, Jonathan Williams, Jörg Wiltfang, Helen Witherow, Jennifer E. Woerner, Jeffrey S. Wolf, Larry M. Wolford, Wai Lup Wong, Martin Woods, Peirong Yu, and Rüdiger M. Zimmerer

Published
2017
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7. The Molecular Biology of Head and Neck Cancer

Author

Richard Shaw and Jag Dhanda

Subjects
0301 basic medicine, Oncology, 03 medical and health sciences, medicine.medical_specialty, 030104 developmental biology, 0302 clinical medicine, business.industry, 030220 oncology & carcinogenesis, Internal medicine, Head and neck cancer, medicine, medicine.disease, business
Published
2017
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12. iKnife Rapid Evaporative Ionisation Mass Spectrometry (REIMS) Technology In Head and Neck Surgery. A Ex Vivo Feasibility Study

Author

Max Robinson, Jag Dhanda, Burak Temelkuran, Emma White, Guang-Zhong Yang, Zoltan Takats, Zsolt Bodai, and Andrew Schache

Subjects
business.industry, Iknife, Mass spectrometry, 03 medical and health sciences, 0302 clinical medicine, Otorhinolaryngology, 030220 oncology & carcinogenesis, Head and neck surgery, Medicine, Surgery, Oral Surgery, 030223 otorhinolaryngology, Nuclear medicine, business, Ex vivo
Published
2017
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14. Invasion of low passage oral carcinoma cells in organotypic models is influenced by the source of both the cancer and cancer-associated fibroblast cells

Author

Jag Dhanda, James B. Wilson, Amelia Acha-Sagredo, Asterios Triantafyllou, R. Sibson, John Stanbury, Janet M. Risk, Julia A. Woolgar, and Richard Shaw

Subjects
Pathology, medicine.medical_specialty, Otorhinolaryngology, business.industry, Carcinoma, Medicine, Cancer associated fibroblast, Cancer, Surgery, Oral Surgery, business, medicine.disease
Published
2016
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16. Abstract 5246: Genomic determinants of aggressive phenotype in oral SCC

Author

Janet M. Risk, Richard Shaw, Bryony H. Lloyd, Jag Dhanda, Julia A. Woolgar, and D R Sibson

Subjects
Cancer Research, Pathology, medicine.medical_specialty, Wnt signaling pathway, Cancer, Keratinocyte activation, Gene signature, Biology, medicine.disease, Actin cytoskeleton, Metastasis, medicine.anatomical_structure, Oncology, Cervical lymph nodes, medicine, Keratinocyte
Abstract

Background: Oral squamous cell carcinoma (OSCC), the common form of HNSCC, affects over 600,000 cases worldwide per annum. We reviewed 561 consecutive cases in Liverpool1 finding that the most predictive marker for death was extra-capsular spread (ECS) from cervical lymph nodes (p Hypothesis: We hypothesised that molecular pathways represented by global gene expression signatures would be detected in the samples associated with ECS. Methods: High density exon array expression analysis was performed on fresh frozen samples comprising T2 and T4 stage OSCC cases having no nodal involvement; positive nodes without ECS or positive nodes plus ECS picked longitudinally from a single centre series (n>200) with bias towards increasing the numbers with ECS. Contingency tests were performed to assess the significance of ECS associated pathways. Results and Discussion: Power analysis showed that 90% of all ≥ twofold differences in gene expression between node negative & ECS cases were significant. Affected pathways included: keratinocyte differentiation, ECM remodelling, chemokines & adhesion, TGF & WNT: cytoskeletal remodelling, regulation of actin cytoskeleton by rho GTPases & cell adhesion/ histamine H1 receptor signalling/loss of cell barrier (p values:7.7×10−15 – 1.9×10−6). A 29 gene signature able to discriminate the ECS from the non-ECS cases with 78% sensitivity and 86% specificity was found. Blocked differentiation of keratinocytes at an early (“stem cell”/ EMT) stage was suggested by the genes which included keratin 15, keratinocyte differentiation-associated protein, retinol binding protein 1, cellular serine peptidase inhibitor (Kazal type 6), and stratifin implicated in mesenchymal stem cells, basal, suprabasal expression and keratinocyte activation and differentiation. The signature may be connected with these tumours having poor prognosis. Conclusion: This is a significant and novel finding suggesting that the pattern of metastasis in regional lymph nodes can be predicted by molecular pathways prevalent in a small oral biopsy. 1. Rogers et al. Oral Oncol 2009;45(3):201-211 2. Shaw et.al. Head Neck 2010;32(6):714-722 Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5246. doi:10.1158/1538-7445.AM2011-5246

Published
2011
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