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8 results on '"Jafary Omid, Nersi"'

7. Preparation, statistical optimization and in vitroevaluation of pramipexole prolonged delivery system based on poly (3-hydroxybutyrate-co-3-hydroxyvalerate) nanoparticles

Author

Bahari Javan, Nika, Jafary Omid, Nersi, Moosavi Hasab, Negar, Rezaie Shirmard, Leila, Rafiee-Tehrani, Morteza, and Dorkoosh, Farid

Abstract

The purpose of the current study was to prepare and optimize a long acting formulation for pramipexole based on poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles (NPs). Pramipexole loaded PHBV NPs were prepared by double emulsion solvent evaporation technique. Box-behnken response surface methodology was utilized to assess the effect of independent variables including PVA concentration, polymer percentage and drug concentration on important properties of NPs. The optimized NPs was shown 228 nm size with 85.43% and 5.68% entrapment efficiency and loading capacity, respectively. The spherical structure of the pramipexole loaded PHBV NPs was proved by scanning electron microscope (SEM). Differential scanning calorimetry (DSC) testified both the absence of undesirable chemical interactions between pramipexole and NPs and the incorporation of pramipexole within the matrix of polymer. In vitrorelease studies demonstrated that 89.9% of pramipexole was gradually released within 30 days based on quasi-fickian diffusion mechanism.

Published
2018
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8. Preparation, statistical optimisation and in vitro characterisation of poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/poly (lactic-co-glycolic acid) blend nanoparticles for prolonged delivery of teriparatide.

Author

Bahari Javan, Nika, Rezaie Shirmard, Leila, Jafary Omid, Nersi, Akbari Javar, Hamid, Rafiee Tehrani, Morteza, and Abedin Dorkoosh, Farid

Subjects
NANOPARTICLES, TERIPARATIDE, TRANSMISSION electron microscopy, DRUGS, COPOLYMERS, FLUORESCENCE spectroscopy
Abstract

The purpose of this study was the preparation, optimisation andin vitrocharacterisation of PHBV and PLGA blend nanoparticles (NPs) for prolonged delivery of Teriparatide. Double emulsion solvent evaporation technique was employed for the fabrication of NPs. The nanoformulation was optimised using the Box–Behnken methodology. The morphological properties of NPs were assessed by both SEM and transmission electron microscopy (TEM). Encapsulation of Teriparatide within the NPs and lacking of chemical bonds between drug and copolymers were proved by XRPD, FTIR and DSC. The structural stability of Teriparatide after processing was confirmed by fluorescence spectrometry. The average size of optimised NPs was 250.0 nm with entrapment efficiency (EE) of 89.5% and drug loading (DL) of 5.0%. Teriparatide release from optimised NPs led to 64.4% release over 30 days and it showed a diffusion-based mechanism. Based on the favourable results, PHBV/PLGA blend NPs could be a promising candidate for designing a controlled release formulation of Teriparatide. [ABSTRACT FROM AUTHOR]

Published
2016
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