Dominic Grande, Yujun Deng, Arin Ryu, Myeong Namkoong, Bong Hoon Kim, Hokyung Jang, Debra E. Weese-Mayer, Christopher Ogle, Jaeseok Jeong, Amy S. Paller, Molly Schau, Naresh R. Shanbhag, Zhaoqian Xie, Casey M. Rand, Yonggang Huang, John A. Rogers, Yechan Lee, Dennis Ryu, Jean Won Kwak, Chi Hwan Lee, Shuai Xu, Kevin You, Yihui Zhang, Pourya Assem, Jeonghyun Kim, Jong Yoon Lee, Ha Uk Chung, Bowen Ji, Anthony Banks, Kun Hyuck Lee, Yongjoon Yu, Xue Feng, Jun Bin Park, Aaron Hamvas, Jongwon Kim, Kyung In Jang, Ji Yoon Jeong, Qingze Huo, Roozbeh Ghaffari, Seungmin Lee, Jungyup Lee, Yeshou Xu, Do Hoon Kim, Zhuangjian Liu, and E. Ibler
Existing vital signmonitoring systems in the neonatal intensive care unit (NICU) requiremultiple wires connected to rigid sensors with strongly adherent interfaces to the skin.We introduce a pair of ultrathin, soft, skin-like electronic devices whose coordinated, wireless operation reproduces the functionality of these traditional technologies but bypasses their intrinsic limitations.The enabling advances in engineering science include designs that support wireless, battery-free operation; real-time, in-sensor data analytics; time-synchronized, continuous data streaming; soft mechanics and gentle adhesive interfaces to the skin; and compatibility with visual inspection and with medical imaging techniques used in the NICU. Preliminary studies on neonates admitted to operating NICUs demonstrate performance comparable to the most advanced clinical-standard monitoring systems. INTRODUCTION In neonatal intensive care units (NICUs), continuous monitoring of vital signs is essential, particularly in cases of severe prematurity. Currentmonitoring platforms requiremultiple hard-wired, rigid interfaces to a neonate’s fragile, underdeveloped skin and, in some cases, invasive lines inserted into their delicate arteries. These platforms and theirwired interfaces pose risks for iatrogenic skin injury, create physical barriers for skin-to-skin parental/neonate bonding, and frustrate even basic clinical tasks. Technologies that bypass these limitations and provide additional, advanced physiological monitoring capabilities would directly address an unmet clinical need for a highly vulnerable population. Wireless, skin-like systems for vital signs monitoring in neonatal intensive care. (A) Images and finite-element modeling results for ECG and PPG devices bent around glass cylinders. (B) A neonate with an ECG device on the chest. (C and D) A mother holding her infant with a PPG device on the foot and an ECG device on the chest (C) and on the back (D). RATIONALE It is now possible to fabricate wireless, battery-free vital signs monitoring systems based on ultrathin, “skin-like” measurement modules. These devices can gently and noninvasively interface onto the skin of neonateswith gestational ages down to the edge of viability. Four essential advances in engineering science serve as the foundations for this technology: (i) schemes for wireless power transfer, low-noise sensing, and high-speed data communications via a single radio-frequency linkwith negligible absorption in biological tissues; (ii) efficient algorithms for real-time data analytics, signal processing, and dynamic baseline modulation implemented on the sensor platforms themselves; (iii) strategies for time-synchronized streaming of wireless data from two separate devices; and (iv) designs that enable visual inspection of the skin interface while also allowing magnetic resonance imaging and x-ray imaging of the neonate. The resulting systems can be much smaller in size, lighter in weight, and less traumatic to the skin than any existing alternative. RESULTS We report the realization of this class ofNICU monitoring technology, embodied as a pair of devices that, when used in a timesynchronized fashion, can reconstruct full vital signs information with clinical-grade precision. One device mounts on the chest to capture electrocardiograms (ECGs); the other rests on the base of the foot to simultaneously record photoplethysmograms (PPGs). This binodal system captures and continuously transmits ECG, PPG, and (fromeach device) skin temperature data, yieldingmeasurements of heart rate, heart rate variability, respiration rate, blood oxygenation, and pulse arrival time as a surrogate of systolic blood pressure. Successful tests on neonates with gestational ages ranging from 28 weeks to full term demonstrate the full range of functions in two level III NICUs. The thin, lightweight, low-modulus characteristics of these wireless devices allow for interfaces to the skinmediated by forces that are nearly an order ofmagnitude smaller than those associated with adhesives used for conventional hardware in the NICU. This reduction greatly lowers the potential for iatrogenic injuries. CONCLUSION The advances outlined here serve as the basis for a skin-like technology that not only reproduces capabilities currently provided by invasive, wired systems as the standard of care, but also offers multipoint sensing of temperature and continuous tracking of blood pressure, all with substantially safer device-skin interfaces and compatibility with medical imaging. By eliminating wired connections, these platforms also facilitate therapeutic skin-to-skin contact between neonates and parents, which is known to stabilize vital signs, reduce morbidity, and promote parental bonding. Beyond use in advanced hospital settings, these systems also offer costeffective capabilities with potential relevance to global health.