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2. Hydrogel-Tissue Adhesion Using Blood Coagulation Induced by Silica Nanoparticle Coatings

Author

Jae Seon Baik, Maïlie Roquart, Gi-Ra Yi, Raphael Michel, Sophie Norvez, Mathieu Manassero, Fabrice Gaslain, Laurent Corté, Elodie Llusar, Chimie Moléculaire, Macromoléculaire et Matériaux (UMR7167) (C3M), Centre National de la Recherche Scientifique (CNRS)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC), Centre des Matériaux (MAT), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Sungkyunkwan University [Suwon] (SKKU), École nationale vétérinaire d'Alfort (ENVA), Biologie, Bioingénierie et Bioimagerie Ostéo-articulaires (B3OA (UMR_7052)), École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), CARRE DE LUSANCAY, GAELLE, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre des Matériaux (CDM), Mines Paris - PSL (École nationale supérieure des mines de Paris), École nationale vétérinaire - Alfort (ENVA), Biologie, Bioingénierie et Bioimagerie Ostéo-articulaires (B3OA), and École nationale vétérinaire - Alfort (ENVA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)

Subjects
[CHIM.POLY] Chemical Sciences/Polymers, Biomedical Engineering, Nanoparticle, 02 engineering and technology, engineering.material, 010402 general chemistry, complex mixtures, 01 natural sciences, Biomaterials, Silica nanoparticles, Coating, Coagulation (water treatment), [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials, Fixation (histology), Tissue Adhesion, Chemistry, Biochemistry (medical), technology, industry, and agriculture, General Chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, [SDV.IB.BIO] Life Sciences [q-bio]/Bioengineering/Biomaterials, [CHIM.POLY]Chemical Sciences/Polymers, Hemostasis, Self-healing hydrogels, engineering, 0210 nano-technology, Biomedical engineering
Abstract

International audience; The fixation of hydrogels to biological tissues is a major challenge conditioning the development of implants and surgical techniques. Here, coatings of procoagulant nanoparticles are devised which use the presence of blood to create adhesion between hydrogels and soft internal organs. Those nanostructured coatings are simply adsorbed at the hydrogel surfaces and can rapidly activate the formation of an interfacial blood clot acting as an adhesive joint. This concept is demonstrated on pig liver capsules with model poly(ethylene-glycol) membranes that are intrinsically poorly adhesive. In the absence of blood, ex vivo peeling tests show that coatings with aggregates of bare silica nanoparticles induce a 2- to 4-fold increase in adhesion energy as compared to the uncoated membrane (3 ± 2 J m–2). This effect is found to scale with the specific surface area of the coating. The highest adhesion energies produced by these nanoparticle-coated membranes (10 ± 5 J m–2) approach the value obtained with cyanoacrylate glue (33 ± 11 J m–2) for which tearing of the tissue is observed. Ex vivo pull-off tests show an adhesion strength of coated membranes around 5 ± 1 kPa, which is significantly reduced when operating in vivo (1.0 ± 0.5 kPa). Nevertheless, when blood is introduced at the interface, the in vivo adhesion strength can be improved remarkably with silica coatings, reaching 4 ± 2 kPa after 40 min contact. In addition, these silica-coated membranes can seal and stop the bleeding produced by liver biopsies very rapidly (

Published
2020
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