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1. Multi-keV X-ray sources from metal-lined cylindrical hohlraums

Author

Jacquet L., Girard F., Villette B., Stemmler Ph., and Primout M.

Subjects
Physics, QC1-999
Abstract

In 2009 a series of metal-lined hohlraums were tested on the Omega laser facility. The main aims of the campaign were to improve our understanding of the multi-keV energy production and our capability to numerically reproduce the measured conversion efficiencies (CE's). Two studies have been primarily planned: the effect of the metallic plasma mean ionization states and that of hydrodynamics. Six targets were experimented for which the metallic materials (titanium, copper, germanium), the cavity diameter, and the irradiation energy were varied. Here we compare experimental and calculated results. The numerical simulations are performed with the 2D hydro-radiative code FCI2. For all the cavities, the measured multi-keV x-ray powers versus time are qualitatively well reproduced by the simulations, indicating that hohlraum hydrodynamics seems to be well calculated. But we have an underestimation by a factor of ∼2 for the calculated CEs versus experimental values for titanium and copper hohlraums. By contrast there is a good agreement between measurements and calculations for the germanium hohlraum. To explain these results, we have calculated off-line integrated emissivities for couples of (ρ, Te) values contributing to the multi-keV production with several non-local-thermal-equilibrium (NLTE) atomic physics models.

Published
2013
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4. 3D in vitro model of a functional epidermal permeability barrier from human embryonic stem cells and induced pluripotent stem cells

Author

Mauro, Theodora, Petrova, A, Celli, A, Jacquet, L, Dafou, D, Crumrine, D, Hupe, M, Arno, M, Hobbs, C, Cvoro, A, and Karagiannis, P

Abstract

Cornification and epidermal barrier defects are associated with a number of clinically diverse skin disorders. However, a suitable in vitro model for studying normal barrier function and barrier defects is still lacking. Here, we demonstrate the generation

Published
2014

5. Investigation of multi-keV silver x-ray sources at OMEGA

Author

Jacquet, L., primary, Lecherbourg, L., additional, Primout, M., additional, Kaiser, P., additional, Gilleron, F., additional, Piron, R., additional, Villette, B., additional, Blancard, C., additional, Soullie, G., additional, Reverdin, C., additional, Vauzour, B., additional, and Legay, G., additional

Published
2023
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17. Bremsstrahlung cannon design for shock ignition relevant regime

Author

Koester, P., Baffigi, F., Cristoforetti, G., Labate, L., Gizzi, L., Sophie Baton, Koenig, M., Colaïtis, A., Batani, D., Casner, A., Raffestin, D., Tentori, A., Trela, J., Rousseaux, C., Boutoux, G., Brygoo, S., Jacquet, L., Reverdin, C., Le Bel, E., Le-Deroff, L., Theobald, W., Shigemori, K., Istituto Nazionale di Ottica (INO), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Laboratoire pour l'utilisation des lasers intenses (LULI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Lasers Intenses et Applications (CELIA), Université de Bordeaux (UB)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), DAM Île-de-France (DAM/DIF), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA-CESTA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratory for lasers energetics - LLE (New-York, USA), University of Rochester [USA], Institute of laser Engineering, Osaka University [Osaka], ANR-10-EQPX-0042,PETAL +,Diagnostics Plasma pour l'installation PETAL sur le LMJ(2010), ANR-10-IDEX-0003,IDEX BORDEAUX,Initiative d'excellence de l'Université de Bordeaux(2010), European Project, Consiglio Nazionale delle Ricerche (CNR), and Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Bordeaux (UB)

Subjects
Inertial Confinement Fusion, [PHYS.PHYS]Physics [physics]/Physics [physics], [PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], Physics::Plasma Physics, Astrophysics::High Energy Astrophysical Phenomena, Physics::Optics, ComputingMilieux_MISCELLANEOUS
Abstract

We report on the optimization of a BremsStrahlung Cannon (BSC) design for the investigation of laser-driven fast electron populations in a shock ignition relevant experimental campaign at the Laser Megajoule-PETawatt Aquitaine Laser facility. In this regime with laser intensities of 10(15) W/cm(2)-10(16) W/cm(2), fast electrons with energies

Published
2021
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27. Shock II

Author

Wolbink, G. J., Baars, J. W., Wagstaff, J., Eerenberg, A., Hack, C. E., Faint, R. W., Mythen, M., Mackie, I. J., Machin, S. J., Routsi, C., Zakynthinos, S., Haviaras, B., Mavromatis, A., Armaganidis, A., Kadas, B., Roussos, Ch., Annane, D., Jars-Guincestre, M. C., Paraire, F., Raphaël, J. C., Lind, L., Mälstam, J., Skoog, G., Teboul, J. -L., Depret, J., Leger, N., Douguet, D., Zelter, M., Mercat, A., Richard, Ch., Saulnier, F., Durocher, A., Cadelis, G., Herengt, F., Wattel, F., Kugler B., Träger K., Holland M., Schricker Th., Georgieff M., Westendorp, R. G. J., Roos, A. N., Simons, R., Frölich, M., Meinders, A. E., Lichtwarck-Aschoff, M., Aschenbrenner, J., Zimmermann, G., Senekowitsch, R., Pfeiffer, U. J., Blümel, G., Lovell, A. T., Hanson, G. C., Jensen, P. J., Andersen, P. K., Thøgersen, C., Poelaert, J. I., Everaert, J. A., Vogelaers, D. P., Decruyenaere, J. M., Colardyn, F. A., Timmins, A. C., Giles, M., Hinds, C. J., Maynard, N., Bihari, D., Mason, R., Baldock, G., McColl, I., Mathieu, D., Neviere, R., Fleyfel, M., Zaknun, J., Fridrich, L., Heute, D., Dyrk, S., Stoeger, A., Seyr, M., Mutz, N., Riccabona G., Lefrant, J. Y., Aya, G., de la Coussaye, J. E., Bassoul, B., Auffray, J. P., Eledjam, J. J., Leucht, S., Kisch, H. W., Goller, R., Belot, J. P., Valtier, B., Mottin, D., Payen, D., Rubini, A., Monte, Del, Attar, I., Catena, E., Rattazzi, G., Alati, G. L., Polisca P., Turani F., Pierri M. D., Sommariva L., de Penta Peppo A., Colella D. F., Zupancich E., Gioffrè P. A., Chiariello L., Descorps-Declère, A., Hollande, J., Beaussier, M., Mimoz, O., Duranteau, J., Edouard, A., Samii, K., Saulnier, F., Drault, J. N., Marzollo, P., Sebastiano, P., Mariotti, M., Burnier, P., Chioléro, R., Goy, J. -J., Schütz, Y., Gombotz, H., Metzler, H., Plaza, J., Berger, J., List, W. F., Angus, D. C., Lidsky, N. M., Dotterweich, L. M., Pinsky, M. R., Evrard, P., de Ruyter, B., Dive, A., Gonzalez, M., Jacquet, L., and Installé, E.

Published
1992
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28. Shock III

Author

Siebenlist, D., Gattenlöhner, W., Lingnau, W., Hörmann, Ch, Putensen, Ch., Mutz, N., Jacquet, L., Jouret, J. C., Henin, P., Goenen, M., Tohmo, H., Karanko, M., Korpilahti, K., Scheinin, M., Viinamäki, O., Neuvonen, P., Sabatè, A., Sopena, R., Ramòn, R., Barcelò, E., Roqueta, C., Abad, A., Garcia, L., Garcia, X., Plaisance, P., Vicaut, E., Beloucif, S., Payen, D., Pasini, L., Ortalli, G., Sorbara, C., Lagonidis, D., Magder, S., Guardiola, J. J., Sarmiento, X., Alonso, S., Nigond J., Arich C., Bertinchant J. P., Bengler C., Stordeur J. M., Chandler, I. M., Stein, K. L., Gasior, T. A., Kormos, R. L., Pinsky, M. R., Fortuna, M., Horvat, M., Szabò, K., Burtin, P., Clavey, M., Mertès, P. M., Levy, B., Bischoff, N., Mathieu, P., Villemot, J. P., Haberer, J. P., El-Banayosy, A., Posival, H., Minami, K., Korner, M. M., Hartmann, D., Korfer, R., El-Banayosy, A., Kortke, H., Corbucci, G. G., Pohar, B., Osredkar, J., Kladnik, S., Bellinzona G., Noli S., Giordano A., Zlzzi S., Maestri M., Spada M., Raimondi M., Albertario F., Dionigi R. V., D’Orio, V., Martinez, C., Saad, G., Mendes, P., Marcelle, R., Staupach, K. H., Losser, M. R., Lenfant, F., Teisseire, B., Bollaert, P. E., Laterre, P. F., Audibert, G., Evenepoel, M., Lelarge, Ph., Larcan, A., Bauer, Ph., Nace, L., Laprevote-Heully, M. C., Larcan, A., Smithies, M. N., Yee, Tai Hwei, Jackson, L., Beale, R., Bihari, D. J., Alonso, C. Cisneros, Rodriguez, J. Gutierrez, Ramirez, F. SAnchez, Varela, J. Prados, Lòpez, P. Arribas, de la Gàndara, A. Martinez, Boiteau, R., Tenaillon, A., Lherm, T., Chamieh, F., Perrin-Gachadoat, D., Burdin, M., Masquelier, A. M., Capron, M. H., Dougnac, A., Andresen, M., Deckers, O., Evenepoel, H., Henin, D., Reynaert, M. S., Müller, C., Probst, S., Lischke, V., Nicovani, V., Hemàndez, G., Bavestrello, L., Castillo, L., Zhang, H., Sparen, H., Benlabed, M., Nuuyen, N., Vincent, J. L., Kunitz, O., Hillermann, T., Glöckner, P., Müller, F. G., and Kalff, G.

Published
1992
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29. Acute/Chronic respiratory failure

Author

De La Cruz, C., Criado, A., Diaz, L., Seiz, A., Vidaur, P. L., Fraile, J. R., Filos, K. S., Goudas, L. C., Dougenis, D., Tassoudis, V., Patroni, O., Winkler, W. -B., Karnik, R., Seelmann, O., Havlicek, J., Stany, J., Becker, H., Peter, J. H., Pitzer, W., Schneider, H., Wichert, P. V., De Blasi R. A., Conti G., Mattia C., Mega A. M., Ferrari M., Gasparetto A., Steltzer, H., Hiesmayr, M., Krafft, P., Petcold, R., Strasser, K., Hammerle, A. F., Capellier, G., Liauw, S., Wintoh, T., Marshall, J., Demajo, W., Barale, F., Walker, P. M., Dugernier, T., Laterre, P. F., Deby-Dupont, G., Lamy, M., Reynaert, M. S., Navarrete, P., Vázquez, G., Rivera, R., Fernandez, E., Mérida, A., Boch, J. N., Eibenberger, K., Herold, C., Schlick, W., van der Heijde, R. M. J. L., Grotjohan, H. P., Versprille, A., Wagenvoort, C. A., Raijmakers, P. G. H. M., Groeneveld, A. B. J., Schneider, A. J., Rauwerda, J. A., Teule, G. J. J., Thija, L. G., Singer, M., Vermaat, J., Hall, G., Latter, G., Patel, M., Jansen, J. R. C., Bordet, F., Mercatello, A., Coronel, B., Bret, M., Tlgaud, J. D., Archimbaud, E., Moskovtchenko, J. F., Gregorakos, L., Katsanos, Ch., Michalopoulos, A., Malessios, V., Mavropanou, D., Nicolopoulos, J., Karageorgiou, K., Tognet, E., Polo, P., Devaux, Y., Fière, D., Valta, P., Takala, J., De Blasio, F., Iannuzzi, E., De Sio, A., Ferraro, F., Schiraldi, F., Mostarda, G. F., Spannbrucker, N., Kiesow, U., Kleinschmidt, R., Reper, P., Marion, E., Van Hille, F., De Neef, H., Heymans, W., Ysebaert, D., Van Hoof, R., Vanderkelen, A., Elsen, M., Gregoretti, C., Beltrame, F., Conti, G., Burbi, L., Antonaglia, V., Lucangelo, U., Biolino, P., Giugiaro, P. M., Sasso, F., Schneider H., Becker H., Cassel W., Peter J. H., von Wichert P., Ludwigs, Ulf, Klingstedt, Christer, Baehrendtz, Svante, Hedenstierna, Göran, Gomez V., De la Casa R., Anon J. M., Pascual C., Jimenez M., Yus S., Angouridakis, P., Sofianos, B., Anastasaki, M., Frantzeskos, G., Askitopoelou, B., Priem, R., Schultheiss, R., Cedzich, C., Rabbat, A., Garrouste, M. T., Nahmias, G., Le Gall, J. R., Schlemmer, B., Wegenius, Göran, Matte, P., Jacquet, L., Ceriani, R., Goenen, M., Roeseler, J., Palavecino, L., Dougnac, A., Reynaert, H., Avila, A., Oliphant, L., Ward, C., Spitzer, Sh., Fink, G., Putensen, C., Leon, M., and Putensen-Himmer, G.

Published
1992
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30. Synthesis and characterization by FAB mass spectrometry of a series of new polymetallic homo- and heteronuclear complexes of ruthenium(II) and rhodium(III) with the symmetric bridging ligand 1,4,5,8,9,12-hexaazatriphenylene

Author

Didier, P., Jacquet L., and Mesmaeker, A. Kirsch-De

Subjects
Mass spectrometry -- Research, Ionization -- Research, Organometallic compounds -- Research, Chemistry
Abstract

The fast atom bombardment mass spectrometry was introduced as a method of analysis of polymetallic complexes. The technique was applied to homo- and heteronuclear complexes of Ru(II) and Rh(III) linked by the ligand 1,4,5,8,9,12-hexaazatriphenylene. The complexes were first ionized by the loss of a negatively charged counterion and then of PF6 species as PF6 radical or anion. Isotopic distribution for each pseudomolecular peak was observed which provided for a clearer characterization of the complexes.

Published
1992

39. Development and validation of the TROLL radiation-hydrodynamics code for 3D hohlraum calculations

Author

Lefebvre, E., primary, Bernard, S., additional, Esnault, C., additional, Gauthier, P., additional, Grisollet, A., additional, Hoch, P., additional, Jacquet, L., additional, Kluth, G., additional, Laffite, S., additional, Liberatore, S., additional, Marmajou, I., additional, Masson-Laborde, P.-E., additional, Morice, O., additional, and Willien, J.-L., additional

Published
2018
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47. TRAZODONE POISONING WITH TORSADES DE POINTE AND PROLONGED NEED FOR INOTROPIC SUPPORT

Author

Wittebole, X, Jacquet, L, Wallemacq, P, and Hantson, Ph

Subjects
Trazodone -- Adverse and side effects, Torsade de pointes -- Causes of, Self-poisoning -- Care and treatment, Environmental issues, Health, Pharmaceuticals and cosmetics industries
Abstract

Objective: To report a case of trazodone intoxication resulting in two episodes of torsades de pointe, prolonged QT interval and need for inotropic support for several days because of hypotension and bradycardia. Case report: A 37-y-old woman was admitted to the emergency department after drug ingestion. Her medical history consisted of depression and chronic ethanol abuse. She was usually taking fluoxetine 40 mg/d, diazepam 10 mg/d and furosemide. At admission, we noted a severe hypotension (70/40 mm Hg) and a relative bradycardia in an otherwise well-awake and responsive patient. She admitted having ingested about 20 pills of trazodone 10 mg and some ethanol. Laboratory data revealed a marked hypokalemia (2.7 mmol/L) without any other disturbance. The ECG showed normal sinus rhythm (64 bpm) with prolonged QT interval (QT/QTc: 520/370 msec). Initial treatment included fluid resuscitation and potassium supplement. Four hours after admission, she presented an episode of torsades de pointe with cardiovascular collapse which was successfully treated by external electric countershock (EEC) at 240 joules. The patient was transferred to the ICU where the treatment remained unchanged unless IV magnesium supplement. At this time, the potassium concentration was 3.25 mmol/L. Four hours later, torsades de pointe and cardiovascular collapse developed again but reversed after EEC (200 joules) and IV magnesium. Transthoracic echocardiography was normal. Because of persistent hypotension, continuous dopamine infusion (doses up to 583 [micro]g/min) was administered with a subsequent increase in heart rhythm (up to 96 bpm) and arterial blood pressure (up to 109/52 mm Hg). Epinephrine infusion with doses up to 5 [micro]g/min had been found ineffective. The need for inotropic support lasted for six days, so did the time for the correction of the QT/QTc interval. The patient was discharged from the hospital three days later. Conclusion: Cardiotoxicity of trazodone is rarely reported. It is known to prolong QT interval in healthy volunteers. Trazodone overdose may result in cardiac conduction abnormalities and dysrhythmias including torsades de pointe that are related to a prolonged QT interval. In our case, the first episode of torsades de pointe was associated with hypokalemia, but not the second. Of more interest is the prolonged need for inotropic support. High doses of dopamine were required to achieve a mild increase in arterial blood pressure. This could be explained by the fact that trazodone should be regarded as an antagonist of the central [Alpha]-adrenoreceptors. We recommend thus close ECG and hemodynamic monitoring in patients admitted with trazodone intoxication associated with ECG abnormalities and/or hypotension. Wittebole X(1), Jacquet L(1), Wallemacq P(2), Hantson Ph(1) (1) Department of Intensive Care (2) Laboratory of Toxicology, Cliniques St-Luc (UCL), Brussels, Belgium

Published
2000

48. SEVERE EEG ABNORMALITIES IN A CASE OF ORAL BACLOFEN OVERDOSE

Author

Meurant, F, de Tourtchaninoff, M, Guerit, JM, Jacquet, L, and Hantson, Ph

Subjects
Baclofen -- Adverse and side effects, Drugs -- Overdose, Self-poisoning -- Care and treatment, Environmental issues, Health, Pharmaceuticals and cosmetics industries
Abstract

Objective: To report clinical and electrophysiological findings in a case of oral baclofen overdose. Case report: A 29-y-old woman was found comatose (Glasgow coma scale 4/15) several hours after a supposed drug overdose. She was intubated by the first medical rescuers and mechanically ventilated. This patient had suffered from limb spasticity for many years and was chronically treated by oral baclofen. The relatives suggested that she could have ingested an unknown amount of baclofen in a suicide attempt. There was no evidence of seizure. On arrival in the Emergency Department, the neurological examination disclosed intermediate unreactive pupils, abolition of deep tendon reflexes and limb flexion in response to painful stimulus. She was correctly ventilated and had a normal arterial blood pressure. A brain CT scan was performed and ruled out a gross anatomical disorder. Routine laboratory data were irrelevant and no other toxic substance could be found at the comprehensive toxicological screen. The first EEG was done 6 h after admission. Background activity was highly abnormal: diffuse and marked slowing (theta activity at 4 to 5 Hz), discontinuity, and lack of reactivity were noted. Numerous transients (sharp waves, triphasic waves and paroxystic slow waves) were recorded either isolated or following a pseudoperiodic pattern; most of them were generalized but some were lateralized to the left hemisphere. The second EEG performed 24 h later showed an alternating pattern with short periods (4-5 seconds) of better defined background activity at 5-6 Hz and large periods of generalized rhythmic delta waves anteriorly predominant. Spontaneous clinical resolution was obtained after 30 h without any antiepileptic drug. The patient could be extubated and was discharged from the ICU without neurological defect. Control EEG performed 5 days later showed a global improvement with a slightly slowed background activity (6-7 Hz), delta and theta activity in excess but no sharp transients were noted at this time. Conclusion: Baclofen is a GABA (gamma aminobutyric acid) analog which is now widely used in the treatment of spasticity. Encephalopathy with confusion, disorientation, slurred speech, agitation, lethargy, euphoria, and hallucinations have been described at therapeutic doses and early in the course of overdose by intrathecal or intravenous administration. It is known that EEG changes associated with baclofen-induced encephalopathy include periodic sharp waves, bursts of triphasic waves, trains of delta activity, intermittent rhythmical delta waves, and diffuse background slowing, but these findings seem uncommon following oral overdose. The recognition of such EEG activity could help to avoid unnecessary prescription of antiepileptic agents. Meurant F(1), de Tourtchaninoff M(2), Guerit JM(2), Jacquet L(1), Hantson Ph(1) (1) Department of Intensive Care (2) Laboratory of Neurophysiology, Cliniques St-Luc (UCL), Brussels, Belgium

Published
2000

50. De B.I.L. ontdekt Athene en Rome

Author

Sevren Jacquet, L. de and Dijkstra, D.

Abstract

Tijdens een lustrumjaar is het gebruikelijk om terug te kijken op het verleden. Wanneer we terugkijken op de historie van de opleiding Bestuurskunde, dan zijn er twee Europese steden van grote invloed geweest op deze studie: Rome en Athene. Voor het eerst in de B.I.L.-geschiedenis werd er tijdens een studiereis een bezoek gebracht aan deze twee steden. Op zaterdag 26 juni 201 O vertokken 22 enthousiaste B .I.L. 'ers naar Athene om vervolgens op 30 juni 2010 door te vliegen naar Rome.

Published
2010

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