1,177 results on '"Jacques Thomas"'
Search Results
2. Preneoplastic Lesions in Surgical Specimens Do Not Worsen the Prognosis of Patients Who Underwent Surgery for Pancreatic Adenocarcinoma: Post-Hoc Analysis of the PRODIGE 24-CCTG PA 6 Trial
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Théo Legrand, Julia Salleron, Thierry Conroy, Frédéric Marchal, Jacques Thomas, Laure Monard, James Jim Biagi, and Aurélien Lambert
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pancreatic cancer ,dysplasia ,PanIN ,IPMN ,MCN ,surgery ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Objective: The prognosis of pancreatic cancer after curative surgery is burdened by frequent recurrence. The aim of this study was to evaluate the impact of dysplasia in the surgical specimen on disease-free survival (DFS). Methods: A post-hoc analysis of the phase III PRODIGE 24-CCTG PA 6 trial was performed. From April 2012 to October 2016, 493 patients were included in the primary study. Assessment for dysplasia in the surgical specimens was secondarily performed. Dysplasia was defined based on presence and grade of three most common pre-malignant lesions (intraductal papillary mucinous neoplasm (IPMN), mucinous cystic neoplasm (MCN) and pancreatic intraepithelial neoplasia (PanIN). The primary endpoint was DFS validated through multivariate analysis. Results: Two hundred twenty-six patients (45.9%) had a preneoplastic lesion. PanIN lesions were found in 193 patients (39.2%), including 100 high-grade lesions (20.6%); 43 patients had IPMN lesions (8.7%), including high-grade lesions in 32 (6.5%). Three MCN were described (0.6%). In bivariate analysis, the presence of dysplasia was not associated with poorer DFS (HR = 0.82, 95% CI [0.66; 1.03]). In multivariate analysis, risk factors for poorer DFS were poorly differentiated/undifferentiated tumor, N1 status, R1 surgical margins and perineural invasion. Conclusions: The presence of dysplasia in the surgical specimen after pancreatic cancer surgery does not worsen DFS.
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- 2022
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3. HPV insertional pattern as a personalized tumor marker for the optimized tumor diagnosis and follow-up of patients with HPV-associated carcinomas: a case report
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Alexandre Harlé, Julie Guillet, Jacques Thomas, Jessica Demange, Gilles Dolivet, Didier Peiffert, Agnès Leroux, and Xavier Sastre-Garau
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HPV ,Tumor biomarkers ,Anal carcinoma ,Head & neck carcinoma ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background In clinical oncology, only a few applications have been developed using HPV as a personalized tumor marker, a lack most probably related to the limited information obtained by the classical Polymerase Chain Reaction (PCR) approach. To overcome this limitation, we have recently developed the capture-based Next-Generation Sequencing (NGS) “CaptHPV” assay, designed to provide an extensive and comprehensive molecular characterization of HPV DNA sequences associated with neoplasias, ie the sequence of the viral genome (245 genotypes), its physical state, viral load, integration site and genomic alterations at integration locus. These data correspond to highly specific tumor markers that can be used to improve diagnosis and patient’s follow-up. Case presentation We report here a case that is a straightforward and practical illustration of the power of the CaptHPV method. A patient developed successively a carcinoma of the anal canal and of the tongue. The two tumors were squamous cell carcinoma, found associated with HPV16 using PCR. In order to document a possible metastasis to the tongue from the anal cancer, we performed CaptHPV analysis on the two tumors. The analysis of the anal carcinoma found 55 viral/human hybrid reads allowing the identification of the HPV16 DNA integration in the 4q25 chromosomal band locus with a 178,808 bp deletion in the cell genome. Molecular analysis of the tongue tumor disclosed 6110 reads of HPV16, with a viral pattern strictly identical to that of the anal tumor. A total of 131 hybrid reads between HPV16 and the cell genome were found, corresponding exactly to the same locus of integration of viral DNA at the 4q25 site. The 178,808 bp genomic deletion was also found in the lingual tumor. The exact identity of HPV insertional signatures in the two tumors, demonstrates unambiguously that the tongue tumor derived from the anal cancer whereas neither histological immunophenotyping nor classical viral analysis using PCR could allow a definitive diagnosis. Conclusion Our observation indicates that the establishment of a detailed cartography of HPV DNA sequences in a tumor specimen provides crucial information for the design of specific biomarkers that can be used for diagnostic, prognostic or predictive purposes.
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- 2019
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4. Paediatric low-grade glioma: the role of classical pathology in integrated diagnostic practice
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Stone, Thomas J., Merve, Ashirwad, Valerio, Fernanda, Yasin, Shireena A., and Jacques, Thomas S.
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- 2024
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5. Antitumor Effect and Induced Immune Response Following Exposure of Hexaminolevulinate and Blue Light in Combination with Checkpoint Inhibitor in an Orthotopic Model of Rat Bladder Cancer
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Laureline Lamy, Jacques Thomas, Agnès Leroux, Jean-François Bisson, Kari Myren, Aslak Godal, Gry Stensrud, and Lina Bezdetnaya
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bladder cancer ,Hexvix® ,photodiagnosis ,PDT ,immune checkpoints ,Biology (General) ,QH301-705.5 - Abstract
Previous studies have found that use of hexaminolevulinate (HAL) and blue light cystoscopy (BLC) during treatment of bladder cancer had a positive impact on overall survival after later cystectomy, indicating a potential treatment effect beyond improved diagnostic accuracy. The aim of our study was to determine whether HAL and BL mimicking clinically relevant doses in an orthotopic rat model could have therapeutic effect by inducing modulation of a tumor-specific immune response. We also assessed whether administration with a checkpoint inhibitor could potentiate any effects observed. Rats were subjected to HAL BL alone and in combination with anti-PD-L1 and assessed for anti-tumor effects and effects on immune markers. Positive anti-tumor effect was observed in 63% and 31% of rats after, respectively, 12 and 30 days after the procedure, together with a localization effect of CD3+ and CD8+ cells after 30 days. Anti-tumor effect at 30 days increases from 31% up to 38% when combined with intravesical anti-PD-L1. In conclusion, our study demonstrated treatment effects with indications of systemic immune activation at diagnostic doses of HAL and blue light. The observed treatment effect seemed to be enhanced when used in combination with intravesically administrated immune checkpoint inhibitor.
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- 2022
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6. Consensus guideline for the diagnosis and management of pituitary adenomas in childhood and adolescence: Part 2, specific diseases
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Korbonits, Márta, Blair, Joanne C., Boguslawska, Anna, Ayuk, John, Davies, Justin H., Druce, Maralyn R., Evanson, Jane, Flanagan, Daniel, Glynn, Nigel, Higham, Claire E., Jacques, Thomas S., Sinha, Saurabh, Simmons, Ian, Thorp, Nicky, Swords, Francesca M., Storr, Helen L., and Spoudeas, Helen A.
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- 2024
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7. Consensus guideline for the diagnosis and management of pituitary adenomas in childhood and adolescence: Part 1, general recommendations
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Korbonits, Márta, Blair, Joanne C., Boguslawska, Anna, Ayuk, John, Davies, Justin H., Druce, Maralyn R., Evanson, Jane, Flanagan, Daniel, Glynn, Nigel, Higham, Claire E., Jacques, Thomas S., Sinha, Saurabh, Simmons, Ian, Thorp, Nicky, Swords, Francesca M., Storr, Helen L., and Spoudeas, Helen A.
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- 2024
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8. Blunt and penetrating cervical trauma
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Awad, Zaid, Jacques, Thomas, and Sharma, Dave
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- 2024
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9. Pediatric-type high-grade neuroepithelial tumors with CIC gene fusion share a common DNA methylation signature
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Sievers, Philipp, Sill, Martin, Schrimpf, Daniel, Abdullaev, Zied, Donson, Andrew M., Lake, Jessica A., Friedel, Dennis, Scheie, David, Tynninen, Olli, Rauramaa, Tuomas, Vepsäläinen, Kaisa L., Samuel, David, Chapman, Rebecca, Grundy, Richard G., Pajtler, Kristian W., Tauziède-Espariat, Arnault, Métais, Alice, Varlet, Pascale, Snuderl, Matija, Jacques, Thomas S., Aldape, Kenneth, Reuss, David E., Korshunov, Andrey, Wick, Wolfgang, Pfister, Stefan M., von Deimling, Andreas, Sahm, Felix, and Jones, David T. W.
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- 2023
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10. Genomic investigations of unexplained acute hepatitis in children
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Morfopoulou, Sofia, Buddle, Sarah, Torres Montaguth, Oscar Enrique, Atkinson, Laura, Guerra-Assunção, José Afonso, Moradi Marjaneh, Mahdi, Zennezini Chiozzi, Riccardo, Storey, Nathaniel, Campos, Luis, Hutchinson, J. Ciaran, Counsell, John R., Pollara, Gabriele, Roy, Sunando, Venturini, Cristina, Antinao Diaz, Juan F., Siam, Ala’a, Tappouni, Luke J., Asgarian, Zeinab, Ng, Joanne, Hanlon, Killian S., Lennon, Alexander, McArdle, Andrew, Czap, Agata, Rosenheim, Joshua, Andrade, Catarina, Anderson, Glenn, Lee, Jack C. D., Williams, Rachel, Williams, Charlotte A., Tutill, Helena, Bayzid, Nadua, Martin Bernal, Luz Marina, Macpherson, Hannah, Montgomery, Kylie-Ann, Moore, Catherine, Templeton, Kate, Neill, Claire, Holden, Matt, Gunson, Rory, Shepherd, Samantha J., Shah, Priyen, Cooray, Samantha, Voice, Marie, Steele, Michael, Fink, Colin, Whittaker, Thomas E., Santilli, Giorgia, Gissen, Paul, Kaufer, Benedikt B., Reich, Jana, Andreani, Julien, Simmonds, Peter, Alrabiah, Dimah K., Castellano, Sergi, Chikowore, Primrose, Odam, Miranda, Rampling, Tommy, Houlihan, Catherine, Hoschler, Katja, Talts, Tiina, Celma, Cristina, Gonzalez, Suam, Gallagher, Eileen, Simmons, Ruth, Watson, Conall, Mandal, Sema, Zambon, Maria, Chand, Meera, Hatcher, James, De, Surjo, Baillie, Kenneth, Semple, Malcolm Gracie, Martin, Joanne, Ushiro-Lumb, Ines, Noursadeghi, Mahdad, Deheragoda, Maesha, Hadzic, Nedim, Grammatikopoulos, Tassos, Brown, Rachel, Kelgeri, Chayarani, Thalassinos, Konstantinos, Waddington, Simon N., Jacques, Thomas S., Thomson, Emma, Levin, Michael, Brown, Julianne R., and Breuer, Judith
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- 2023
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11. GNAQ/GNA11 Mosaicism Is Associated with Abnormal Serum Calcium Indices and Microvascular Neurocalcification
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Knöpfel, Nicole, Zecchin, Davide, Richardson, Hanna, Polubothu, Satyamaanasa, Barberan-Martin, Sara, Cullup, Thomas, Gholam, Karolina, Heales, Simon, Krywawych, Steve, López-Balboa, Pablo, Muwanga-Nanyonjo, Noreen, Ogunbiyi, Olumide, Puvirajasinghe, Clinda, Solman, Lea, Swarbrick, Katherine, Syed, Samira B., Tahir, Zubair, Tisdall, Martin M., Allgrove, Jeremy, Chesover, Alexander D., Aylett, Sarah E., Jacques, Thomas S., Hannan, Fadil M., Löbel, Ulrike, Semple, Robert K., Thakker, Rajesh V., and Kinsler, Veronica A.
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- 2024
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12. National UK guidelines for the management of paediatric craniopharyngioma
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Gan, Hoong-Wei, Morillon, Paul, Albanese, Assunta, Aquilina, Kristian, Chandler, Chris, Chang, Yen-Ching, Drimtzias, Evangelos, Farndon, Sarah, Jacques, Thomas S, Korbonits, Márta, Kuczynski, Adam, Limond, Jennifer, Robinson, Louise, Simmons, Ian, Thomas, Nick, Thomas, Sophie, Thorp, Nicola, Vargha-Khadem, Faraneh, Warren, Daniel, Zebian, Bassel, Mallucci, Conor, and Spoudeas, Helen Alexandra
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- 2023
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13. A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR.
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Sievers, Philipp, Sill, Martin, Schrimpf, Daniel, Stichel, Damian, Reuss, David E, Sturm, Dominik, Hench, Jürgen, Frank, Stephan, Krskova, Lenka, Vicha, Ales, Zapotocky, Michal, Bison, Brigitte, Castel, David, Grill, Jacques, Debily, Marie-Anne, Harter, Patrick N, Snuderl, Matija, Kramm, Christof M, Reifenberger, Guido, Korshunov, Andrey, Jabado, Nada, Wesseling, Pieter, Wick, Wolfgang, Solomon, David A, Perry, Arie, Jacques, Thomas S, Jones, Chris, Witt, Olaf, Pfister, Stefan M, von Deimling, Andreas, Jones, David TW, and Sahm, Felix
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Brain Disorders ,Pediatric Cancer ,Cancer ,Pediatric ,Brain Cancer ,Rare Diseases ,Genetics ,Neurosciences ,Brain Neoplasms ,Child ,DNA Methylation ,ErbB Receptors ,Genes ,erbB-1 ,Glioma ,Histones ,Humans ,Mutation ,Thalamus ,(bi)thalamic ,EGFR mutation ,H3 K27M mutation ,K27me3 ,pediatric-type high-grade glioma ,EGFR mutation ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
BackgroundMalignant astrocytic gliomas in children show a remarkable biological and clinical diversity. Small in-frame insertions or missense mutations in the epidermal growth factor receptor gene (EGFR) have recently been identified in a distinct subset of pediatric-type bithalamic gliomas with a unique DNA methylation pattern.MethodsHere, we investigated an epigenetically homogeneous cohort of malignant gliomas (n = 58) distinct from other subtypes and enriched for pediatric cases and thalamic location, in comparison with this recently identified subtype of pediatric bithalamic gliomas.ResultsEGFR gene amplification was detected in 16/58 (27%) tumors, and missense mutations or small in-frame insertions in EGFR were found in 20/30 tumors with available sequencing data (67%; 5 of them co-occurring with EGFR amplification). Additionally, 8 of the 30 tumors (27%) harbored an H3.1 or H3.3 K27M mutation (6 of them with a concomitant EGFR alteration). All tumors tested showed loss of H3K27me3 staining, with evidence of overexpression of the EZH inhibitory protein (EZHIP) in the H3 wildtype cases. Although some tumors indeed showed a bithalamic growth pattern, a significant proportion of tumors occurred in the unilateral thalamus or in other (predominantly midline) locations.ConclusionsOur findings present a distinct molecular class of pediatric-type malignant gliomas largely overlapping with the recently reported bithalamic gliomas characterized by EGFR alteration, but additionally showing a broader spectrum of EGFR alterations and tumor localization. Global H3K27me3 loss in this group appears to be mediated by either H3 K27 mutation or EZHIP overexpression. EGFR inhibition may represent a potential therapeutic strategy in these highly aggressive gliomas.
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- 2021
14. Epigenetic profiling reveals a subset of pediatric-type glioneuronal tumors characterized by oncogenic gene fusions involving several targetable kinases
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Sievers, Philipp, Sill, Martin, Schrimpf, Daniel, Friedel, Dennis, Sturm, Dominik, Gardberg, Maria, Kurian, Kathreena M., Krskova, Lenka, Vicha, Ales, Schaller, Tina, Hagel, Christian, Abdullaev, Zied, Aldape, Kenneth, Jacques, Thomas S., Korshunov, Andrey, Wick, Wolfgang, Pfister, Stefan M., von Deimling, Andreas, Jones, David T. W., and Sahm, Felix
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- 2022
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15. Searching for long-lived particles beyond the Standard Model at the Large Hadron Collider
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Alimena, Juliette, Beacham, James, Borsato, Martino, Cheng, Yangyang, Vidal, Xabier Cid, Cottin, Giovanna, De Roeck, Albert, Desai, Nishita, Curtin, David, Evans, Jared A., Knapen, Simon, Kraml, Sabine, Lessa, Andre, Liu, Zhen, Mehlhase, Sascha, Ramsey-Musolf, Michael J., Russell, Heather, Shelton, Jessie, Shuve, Brian, Verducci, Monica, Zurita, Jose, Adams, Todd, Adersberger, Michael, Alpigiani, Cristiano, Apresyan, Artur, Bainbridge, Robert John, Batozskaya, Varvara, Beauchesne, Hugues, Benato, Lisa, Berlendis, S., Bhal, Eshwen, Blekman, Freya, Borovilou, Christina, Boyd, Jamie, Brau, Benjamin P., Bryngemark, Lene, Buchmueller, Oliver, Buschmann, Malte, Buttinger, William, Campanelli, Mario, Cesarotti, Cari, Chen, Chunhui, Cheng, Hsin-Chia, Cheong, Sanha, Citron, Matthew, Coccaro, Andrea, Coco, V., Conte, Eric, Cormier, Félix, Corpe, Louie D., Craig, Nathaniel, Cui, Yanou, Dall'Occo, Elena, Dallapiccola, C., Darwish, M. R., Davoli, Alessandro, de Cosa, Annapaola, De Simone, Andrea, Rose, Luigi Delle, Deppisch, Frank F., Dey, Biplab, Diamond, Miriam D., Dienes, Keith R., Dildick, Sven, Döbrich, Babette, Drewes, Marco, Eich, Melanie, ElSawy, M., del Valle, Alberto Escalante, Facini, Gabriel, Farina, Marco, Feng, Jonathan L., Fischer, Oliver, Flaecher, H. U., Foldenauer, Patrick, Freytsis, Marat, Fuks, Benjamin, Galon, Iftah, Gershtein, Yuri, Giagu, Stefano, Giammanco, Andrea, Gligorov, Vladimir V., Golling, Tobias, Grancagnolo, Sergio, Gustavino, Giuliano, Haas, Andrew, Hahn, Kristian, Hajer, Jan, Hammad, Ahmed, Heinrich, Lukas, Heisig, Jan, Helo, J. C., Hesketh, Gavin, Hill, Christopher S., Hirsch, Martin, Hohlmann, M., Hulsbergen, W., Huth, John, Ilten, Philip, Jacques, Thomas, Jayatilaka, Bodhitha, Jeng, Geng-Yuan, Johns, K. A., Kaji, Toshiaki, Kasieczka, Gregor, Kats, Yevgeny, Kazana, Malgorzata, Keller, Henning, Khlopov, Maxim Yu., Kling, Felix, Kolberg, Ted R., Kostiuk, Igor, Kuwertz, Emma Sian, Kvam, Audrey, Landsberg, Greg, Lanfranchi, Gaia, Lara, Iñaki, Ledovskoy, Alexander, Linthorne, Dylan, Liu, Jia, Longarini, Iacopo, Lowette, Steven, Lubatti, Henry, Lutz, Margaret, Luo, Jingyu, Mamužić, Judita, Marinangeli, Matthieu, Mariotti, Alberto, Marlow, Daniel, McCullough, Matthew, McDermott, Kevin, Mermod, P., Milstead, David, Mitsou, Vasiliki A., Berlingen, Javier Montejo, Moortgat, Filip, Morandini, Alessandro, Morris, Alice Polyxeni, Morse, David Michael, Mrenna, Stephen, Nachman, Benjamin, Nemevšek, Miha, Nesti, Fabrizio, Ohm, Christian, Pascoli, Silvia, Pedro, Kevin, Peña, Cristián, Rodriguez, Karla Josefina Pena, Piedra, Jónatan, Pinfold, James L., Policicchio, Antonio, Popara, Goran, Prisciandaro, Jessica, Proffitt, Mason, Rauco, Giorgia, Redi, Federico, Reece, Matthew, Hall, Allison Reinsvold, Sfar, H. Rejeb, Renner, Sophie, Roepe, Amber, Ronzani, Manfredi, Salvioni, Ennio, Santra, Arka, Sawada, Ryu, Scholtz, Jakub, Schuster, Philip, Schwaller, Pedro, Sebastiani, Cristiano, Sekmen, Sezen, Selvaggi, Michele, Si, Weinan, Soffi, Livia, Stolarski, Daniel, Stuart, David, Stupak III, John, Sung, Kevin, Taylor, Wendy, Templ, Sebastian, Thomas, Brooks, Torró-Pastor, Emma, Trocino, Daniele, Trojanowski, Sebastian, Trovato, Marco, Tsai, Yuhsin, Tully, C. G., Vámi, Tamás Álmos, Vasquez, Juan Carlos, Sierra, Carlos Vázquez, Vellidis, K., Vermassen, Basile, Vit, Martina, Walker, Devin G. E., Wang, Xiao-Ping, Watts, Gordon, Xie, Si, Yexley, Melissa, Young, Charles, Yu, Jiang-Hao, Zalewski, Piotr, and Zhang, Yongchao
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High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
Particles beyond the Standard Model (SM) can generically have lifetimes that are long compared to SM particles at the weak scale. When produced at experiments such as the Large Hadron Collider (LHC) at CERN, these long-lived particles (LLPs) can decay far from the interaction vertex of the primary proton-proton collision. Such LLP signatures are distinct from those of promptly decaying particles that are targeted by the majority of searches for new physics at the LHC, often requiring customized techniques to identify, for example, significantly displaced decay vertices, tracks with atypical properties, and short track segments. Given their non-standard nature, a comprehensive overview of LLP signatures at the LHC is beneficial to ensure that possible avenues of the discovery of new physics are not overlooked. Here we report on the joint work of a community of theorists and experimentalists with the ATLAS, CMS, and LHCb experiments --- as well as those working on dedicated experiments such as MoEDAL, milliQan, MATHUSLA, CODEX-b, and FASER --- to survey the current state of LLP searches at the LHC, and to chart a path for the development of LLP searches into the future, both in the upcoming Run 3 and at the High-Luminosity LHC. The work is organized around the current and future potential capabilities of LHC experiments to generally discover new LLPs, and takes a signature-based approach to surveying classes of models that give rise to LLPs rather than emphasizing any particular theory motivation. We develop a set of simplified models; assess the coverage of current searches; document known, often unexpected backgrounds; explore the capabilities of proposed detector upgrades; provide recommendations for the presentation of search results; and look towards the newest frontiers, namely high-multiplicity "dark showers", highlighting opportunities for expanding the LHC reach for these signals.
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- 2019
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16. Dark Matter benchmark models for early LHC Run-2 Searches: Report of the ATLAS/CMS Dark Matter Forum
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Abercrombie, Daniel, Akchurin, Nural, Akilli, Ece, Maestre, Juan Alcaraz, Allen, Brandon, Gonzalez, Barbara Alvarez, Andrea, Jeremy, Arbey, Alexandre, Azuelos, Georges, Azzi, Patrizia, Backović, Mihailo, Bai, Yang, Banerjee, Swagato, Beacham, James, Belyaev, Alexander, Boveia, Antonio, Brennan, Amelia Jean, Buchmueller, Oliver, Buckley, Matthew R, Busoni, Giorgio, Buttignol, Michael, Cacciapaglia, Giacomo, Caputo, Regina, Carpenter, Linda, Castro, Nuno Filipe, Ceballos, Guillelmo Gomez, Cheng, Yangyang, Chou, John Paul, Gonzalez, Arely Cortes, Cowden, Chris, D’Eramo, Francesco, De Cosa, Annapaola, De Gruttola, Michele, De Roeck, Albert, De Simone, Andrea, Deandrea, Aldo, Demiragli, Zeynep, DiFranzo, Anthony, Doglioni, Caterina, du Pree, Tristan, Erbacher, Robin, Erdmann, Johannes, Fischer, Cora, Flaecher, Henning, Fox, Patrick J, Fuks, Benjamin, Genest, Marie-Helene, Gomber, Bhawna, Goudelis, Andreas, Gramling, Johanna, Gunion, John, Hahn, Kristian, Haisch, Ulrich, Harnik, Roni, Harris, Philip C, Hoepfner, Kerstin, Hoh, Siew Yan, Hsu, Dylan George, Hsu, Shih-Chieh, Iiyama, Yutaro, Ippolito, Valerio, Jacques, Thomas, Ju, Xiangyang, Kahlhoefer, Felix, Kalogeropoulos, Alexis, Kaplan, Laser Seymour, Kashif, Lashkar, Khoze, Valentin V, Khurana, Raman, Kotov, Khristian, Kovalskyi, Dmytro, Kulkarni, Suchita, Kunori, Shuichi, Kutzner, Viktor, Lee, Hyun Min, Lee, Sung-Won, Liew, Seng Pei, Lin, Tongyan, Lowette, Steven, Madar, Romain, Malik, Sarah, Maltoni, Fabio, Perez, Mario Martinez, Mattelaer, Olivier, Mawatari, Kentarou, McCabe, Christopher, Megy, Théo, Morgante, Enrico, Mrenna, Stephen, Moon, Chang-Seong, Narayanan, Siddharth M, Nelson, Andy, Novaes, Sérgio F, Padeken, Klaas Ole, Pani, Priscilla, Papucci, Michele, Paulini, Manfred, Paus, Christoph, Pazzini, Jacopo, and Penning, Björn
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Nuclear and Plasma Physics ,Particle and High Energy Physics ,Physical Sciences ,Dark Matter ,Simplified models ,EFT ,LHC ,hep-ex ,hep-ph ,Astronomical and Space Sciences ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Astronomical sciences ,Particle and high energy physics - Abstract
This document is the final report of the ATLAS-CMS Dark Matter Forum, a forum organized by the ATLAS and CMS collaborations with the participation of experts on theories of Dark Matter, to select a minimal basis set of dark matter simplified models that should support the design of the early LHC Run-2 searches. A prioritized, compact set of benchmark models is proposed, accompanied by studies of the parameter space of these models and a repository of generator implementations. This report also addresses how to apply the Effective Field Theory formalism for collider searches and present the results of such interpretations.
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- 2020
17. 2021 WHO classification of tumours of the central nervous system: a review for the neuroradiologist
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McNamara, Cillian, Mankad, Kshitij, Thust, Stefanie, Dixon, Luke, Limback-Stanic, Clara, D’Arco, Felice, Jacques, Thomas S., and Löbel, Ulrike
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- 2022
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18. Acquired Diseases of the Nervous System
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Smith, Colin, Jacques, Thomas S., Khong, T. Yee, editor, and Malcomson, Roger D. G., editor
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- 2022
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19. The NHS England 100,000 Genomes Project: feasibility and utility of centralised genome sequencing for children with cancer
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Trotman, Jamie, Armstrong, Ruth, Firth, Helen, Trayers, Claire, Watkins, James, Allinson, Kieren, Jacques, Thomas S., Nicholson, James C., Burke, G. A. Amos, Behjati, Sam, Murray, Matthew J., Hook, Catherine E., and Tarpey, Patrick
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- 2022
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20. Guiding New Physics Searches with Unsupervised Learning
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De Simone, Andrea and Jacques, Thomas
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment ,Physics - Data Analysis, Statistics and Probability - Abstract
We propose a new scientific application of unsupervised learning techniques to boost our ability to search for new phenomena in data, by detecting discrepancies between two datasets. These could be, for example, a simulated standard-model background, and an observed dataset containing a potential hidden signal of New Physics. We build a statistical test upon a test statistic which measures deviations between two samples, using a Nearest Neighbors approach to estimate the local ratio of the density of points. The test is model-independent and non-parametric, requiring no knowledge of the shape of the underlying distributions, and it does not bin the data, thus retaining full information from the multidimensional feature space. As a proof-of-concept, we apply our method to synthetic Gaussian data, and to a simulated dark matter signal at the Large Hadron Collider. Even in the case where the background can not be simulated accurately enough to claim discovery, the technique is a powerful tool to identify regions of interest for further study., Comment: 25 pages, 7 figures. Updated with new treatment of uncertainties and to match published version
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- 2018
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21. LHC Phenomenology of Dark Matter with a Color-Octet Partner
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Davoli, Alessandro, De Simone, Andrea, Jacques, Thomas, and Morandini, Alessandro
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High Energy Physics - Phenomenology - Abstract
Colored dark sectors where the dark matter particle is accompanied by colored partners have recently attracted theoretical and phenomenological interest. We explore the possibility that the dark sector consists of the dark matter particle and a color-octet partner, where the interaction with the Standard Model is governed by an effective operator involving gluons. The resulting interactions resemble the color analogues of electric and magnetic dipole moments. Although many phenomenological features of this kind of model only depend on the group representation of the partner under SU(3)$_c$, we point out that interesting collider signatures such as $R$-hadrons are indeed controlled by the interaction operator between the dark and visible sector. We perform a study of the current constraints and future reach of LHC searches, where the complementarity between different possible signals is highlighted and exploited., Comment: 17 pages, 7 figures, matches published version
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- 2018
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22. Displaced Vertices from Pseudo-Dirac Dark Matter
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Davoli, Alessandro, De Simone, Andrea, Jacques, Thomas, and Sanz, Verónica
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High Energy Physics - Phenomenology - Abstract
Displaced vertices are relatively unusual signatures for dark matter searches at the LHC. We revisit the model of pseudo-Dirac dark matter (pDDM), which can accommodate the correct relic density, evade direct detection constraints, and generically provide observable collider signatures in the form of displaced vertices. We use this model as a benchmark to illustrate the general techniques involved in the analysis, the complementarity between monojet and displaced vertex searches, and provide a comprehensive study of the current bounds and prospective reach., Comment: 23 pages, 4 figures, 2 tables
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- 2017
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23. Sensitivity of the Cherenkov Telescope Array to the detection of a dark matter signal in comparison to direct detection and collider experiments
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Balázs, Csaba, Conrad, Jan, Farmer, Ben, Jacques, Thomas, Li, Tong, Meyer, Manuel, Queiroz, Farinaldo S., and Sánchez-Conde, Miguel A.
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Astrophysics - High Energy Astrophysical Phenomena ,High Energy Physics - Phenomenology - Abstract
Imaging atmospheric Cherenkov telescopes (IACTs) that are sensitive to potential $\gamma$-ray signals from dark matter (DM) annihilation above $\sim50$ GeV will soon be superseded by the Cherenkov Telescope Array (CTA). CTA will have a point source sensitivity an order of magnitude better than currently operating IACTs and will cover a broad energy range between 20 GeV and 300 TeV. Using effective field theory and simplified models to calculate $\gamma$-ray spectra resulting from DM annihilation, we compare the prospects to constrain such models with CTA observations of the Galactic center with current and near-future measurements at the Large Hadron Collider (LHC) and direct detection experiments. For DM annihilations via vector or pseudoscalar couplings, CTA observations will be able to probe DM models out of reach of the LHC, and, if DM is coupled to standard fermions by a pseudoscalar particle, beyond the limits of current direct detection experiments., Comment: Accepted for publication in PRD. 20 pages, 11 figures
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- 2017
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24. Decision making for health‐related research outcomes that alter diagnosis: A model from paediatric brain tumours.
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Pickles, Jessica C., Aquilina, Kristian, Chalker, Jane, Dahl, Christine, Devadass, Abel, Mankad, Kshitij, Merve, Ashirwad, Ahmed, Munaza, Nicoll, James A. R., Bloom, Tabitha, Hilton, David A., Sebire, Neil J., Hargrave, Darren, and Jacques, Thomas S.
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BRAIN tumors ,PEDIATRIC pathology ,GENETIC disorders ,MOLECULAR pathology ,DEGENERATION (Pathology) - Abstract
Aims: The question of how to handle clinically actionable outcomes from retrospective research studies is poorly explored. In neuropathology, this problem is exacerbated by ongoing refinement in tumour classification. We sought to establish a disclosure threshold for potential revised diagnoses as determined by the neuro‐oncology speciality. Methods: As part of a previous research study, the diagnoses of 73 archival paediatric brain tumour samples were reclassified according to the WHO 2016 guidelines. To determine the disclosure threshold and clinical actionability of pathology‐related findings, we conducted a result‐evaluation approach within the ethical framework of BRAIN UK using a surrogate clinical multidisciplinary team (MDT) of neuro‐oncology specialists. Results: The MDT identified key determinants impacting decision‐making, including anticipated changes to patient management, time elapsed since initial diagnosis, likelihood of the patient being alive and absence of additional samples since cohort inception. Ultimately, none of our research findings were considered clinically actionable, largely due to the cohort's historic archival and high‐risk nature. From this experience, we developed a decision‐making framework to determine if research findings indicating a change in diagnosis require reporting to the relevant clinical teams. Conclusions: Ethical issues relating to the use of archival tissue for research and the potential to identify actionable findings must be carefully considered. We have established a structured framework to assess the actionability of research data relating to patient diagnosis. While our specific findings are most applicable to the pathology of poor prognostic brain tumour groups in children, the model can be adapted to a range of disease settings, for example, other diseases where research is dependent on retrospective tissue cohorts, and research findings may have implications for patients and families, such as other tumour types, epilepsy‐related pathology, genetic disorders and degenerative diseases. [ABSTRACT FROM AUTHOR]
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- 2024
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25. Evaluation and Investigation of Pituitary Disease
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Jacques, Thomas, primary
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- 2022
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26. Nasal Fractures
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Shamil, Eamon, primary, Jacques, Thomas, additional, and Surda, Pavol, additional
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- 2022
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27. Quantitative MRI susceptibility mapping reveals cortical signatures of changes in iron, calcium and zinc in malformations of cortical development in children with drug-resistant epilepsy
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Lorio, Sara, Sedlacik, Jan, So, Po-Wah, Parkes, Harold G., Gunny, Roxana, Löbel, Ulrike, Li, Yao-Feng, Ogunbiyi, Olumide, Mistry, Talisa, Dixon, Emma, Adler, Sophie, Cross, J. Helen, Baldeweg, Torsten, Jacques, Thomas S., Shmueli, Karin, and Carmichael, David W
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- 2021
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28. Blunt and penetrating cervical trauma
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Awad, Zaid and Jacques, Thomas
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- 2021
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29. Complementarity of DM Searches in a Consistent Simplified Model: the Case of Z'
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Jacques, Thomas, Katz, Andrey, Morgante, Enrico, Racco, Davide, Rameez, Mohamed, and Riotto, Antonio
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High Energy Physics - Phenomenology ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We analyze the constraints from direct and indirect detection on fermionic Majorana Dark Matter (DM). Because the interaction with the Standard Model (SM) particles is spin-dependent, a priori the constraints that one gets from neutrino telescopes, the LHC, direct and indirect detection experiments are comparable. We study the complementarity of these searches in a particular example, in which a heavy $Z'$ mediates the interactions between the SM and the DM. We find that for heavy dark matter indirect detection provides the strongest bounds on this scenario, while IceCube bounds are typically stronger than those from direct detection. The LHC constraints are dominant for smaller dark matter masses. These light masses are less motivated by thermal relic abundance considerations. We show that the dominant annihilation channels of the light DM in the Sun and the Galactic Center are either $b\bar b$ or $t\bar t$, while the heavy DM annihilation is completely dominated by $Zh$ channel. The latter produces a hard neutrino spectrum which has not been previously analyzed. We study the neutrino spectrum yielded by DM and recast IceCube constraints to allow proper comparison with constraints from direct and indirect detection experiments and LHC exclusions. Note that the original version of the paper contains an important error: the contribution of the $Z$-mediated processes was overlooked. This changes some of the results of the paper. For the details and the correct results please see the erratum attached to this file as an appendix., Comment: v1: 38 pages, 8 figures; v2: added references; v3: matches published version: added a recast of the indirect constraints from Fermi-LAT observations of Dwarf Spheroidal Galaxies; v4: corrected an important error, by including the Z exchange, updating the result and attaching an erratum
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- 2016
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30. Simplified Models vs. Effective Field Theory Approaches in Dark Matter Searches
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De Simone, Andrea and Jacques, Thomas
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment - Abstract
In this review we discuss and compare the usage of simplified models and Effective Field Theory (EFT) approaches in dark matter searches. We provide a state of the art description on the subject of EFTs and simplified models, especially in the context of collider searches for dark matter, but also with implications for direct and indirect detection searches, with the aim of constituting a common language for future comparisons between different strategies. The material is presented in a form that is as self-contained as possible, so that it may serve as an introductory review for the newcomer as well as a reference guide for the practitioner., Comment: 52 pages. Invited review for Eur. Phys. J. C. v2: Updated to match published version. References added and other minor changes
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- 2016
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31. Constitutional mismatch repair deficiency (CMMRD) presenting with high-grade glioma, multiple developmental venous anomalies and malformations of cortical development—a multidisciplinary/multicentre approach and neuroimaging clues to clinching the diagnosis
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Chhabda, Sahil, Sudhakar, Sniya, Mankad, Kshitij, Jorgensen, Mette, Carceller, Fernando, Jacques, Thomas S., Merve, Ashirwad, Aizpurua, Miren, Chalker, Jane, Garimberti, Elisa, and D’Arco, Felice
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- 2021
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32. Dark Matter Benchmark Models for Early LHC Run-2 Searches: Report of the ATLAS/CMS Dark Matter Forum
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Abercrombie, Daniel, Akchurin, Nural, Akilli, Ece, Maestre, Juan Alcaraz, Allen, Brandon, Gonzalez, Barbara Alvarez, Andrea, Jeremy, Arbey, Alexandre, Azuelos, Georges, Azzi, Patrizia, Backović, Mihailo, Bai, Yang, Banerjee, Swagato, Beacham, James, Belyaev, Alexander, Boveia, Antonio, Brennan, Amelia Jean, Buchmueller, Oliver, Buckley, Matthew R., Busoni, Giorgio, Buttignol, Michael, Cacciapaglia, Giacomo, Caputo, Regina, Carpenter, Linda, Castro, Nuno Filipe, Ceballos, Guillelmo Gomez, Cheng, Yangyang, Chou, John Paul, Gonzalez, Arely Cortes, Cowden, Chris, D'Eramo, Francesco, De Cosa, Annapaola, De Gruttola, Michele, De Roeck, Albert, De Simone, Andrea, Deandrea, Aldo, Demiragli, Zeynep, DiFranzo, Anthony, Doglioni, Caterina, Pree, Tristan du, Erbacher, Robin, Erdmann, Johannes, Fischer, Cora, Flaecher, Henning, Fox, Patrick J., Fuks, Benjamin, Genest, Marie-Helene, Gomber, Bhawna, Goudelis, Andreas, Gramling, Johanna, Gunion, John, Hahn, Kristian, Haisch, Ulrich, Harnik, Roni, Harris, Philip C., Hoepfner, Kerstin, Hoh, Siew Yan, Hsu, Dylan George, Hsu, Shih-Chieh, Iiyama, Yutaro, Ippolito, Valerio, Jacques, Thomas, Ju, Xiangyang, Kahlhoefer, Felix, Kalogeropoulos, Alexis, Kaplan, Laser Seymour, Kashif, Lashkar, Khoze, Valentin V., Khurana, Raman, Kotov, Khristian, Kovalskyi, Dmytro, Kulkarni, Suchita, Kunori, Shuichi, Kutzner, Viktor, Lee, Hyun Min, Lee, Sung-Won, Liew, Seng Pei, Lin, Tongyan, Lowette, Steven, Madar, Romain, Malik, Sarah, Maltoni, Fabio, Perez, Mario Martinez, Mattelaer, Olivier, Mawatari, Kentarou, McCabe, Christopher, Megy, Théo, Morgante, Enrico, Mrenna, Stephen, Narayanan, Siddharth M., Nelson, Andy, Novaes, Sérgio F., Padeken, Klaas Ole, Pani, Priscilla, Papucci, Michele, Paulini, Manfred, Paus, Christoph, Pazzini, Jacopo, Penning, Björn, Peskin, Michael E., Pinna, Deborah, Procura, Massimiliano, Qazi, Shamona F., Racco, Davide, Re, Emanuele, Riotto, Antonio, Rizzo, Thomas G., Roehrig, Rainer, Salek, David, Pineda, Arturo Sanchez, Sarkar, Subir, Schmidt, Alexander, Schramm, Steven Randolph, Shepherd, William, Singh, Gurpreet, Soffi, Livia, Srimanobhas, Norraphat, Sung, Kevin, Tait, Tim M. P., Theveneaux-Pelzer, Timothee, Thomas, Marc, Tosi, Mia, Trocino, Daniele, Undleeb, Sonaina, Vichi, Alessandro, Wang, Fuquan, Wang, Lian-Tao, Wang, Ren-Jie, Whallon, Nikola, Worm, Steven, Wu, Mengqing, Wu, Sau Lan, Yang, Hongtao, Yang, Yong, Yu, Shin-Shan, Zaldivar, Bryan, Zanetti, Marco, Zhang, Zhiqing, and Zucchetta, Alberto
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High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
This document is the final report of the ATLAS-CMS Dark Matter Forum, a forum organized by the ATLAS and CMS collaborations with the participation of experts on theories of Dark Matter, to select a minimal basis set of dark matter simplified models that should support the design of the early LHC Run-2 searches. A prioritized, compact set of benchmark models is proposed, accompanied by studies of the parameter space of these models and a repository of generator implementations. This report also addresses how to apply the Effective Field Theory formalism for collider searches and present the results of such interpretations.
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- 2015
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33. Simplified Models for Dark Matter Searches at the LHC
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Abdallah, Jalal, Araujo, Henrique, Arbey, Alexandre, Ashkenazi, Adi, Belyaev, Alexander, Berger, Joshua, Boehm, Celine, Boveia, Antonio, Brennan, Amelia, Brooke, Jim, Buchmueller, Oliver, Buckley, Matthew, Busoni, Giorgio, Calibbi, Lorenzo, Chauhan, Sushil, Daci, Nadir, Davies, Gavin, De Bruyn, Isabelle, De Jong, Paul, De Roeck, Albert, de Vries, Kees, Del Re, Daniele, De Simone, Andrea, Di Simone, Andrea, Doglioni, Caterina, Dolan, Matthew, Dreiner, Herbi K., Ellis, John, Eno, Sarah, Etzion, Erez, Fairbairn, Malcolm, Feldstein, Brian, Flaecher, Henning, Feng, Eric, Fox, Patrick, Genest, Marie-Hélène, Gouskos, Loukas, Gramling, Johanna, Haisch, Ulrich, Harnik, Roni, Hibbs, Anthony, Hoh, Siewyan, Hopkins, Walter, Ippolito, Valerio, Jacques, Thomas, Kahlhoefer, Felix, Khoze, Valentin V., Kirk, Russell, Korn, Andreas, Kotov, Khristian, Kunori, Shuichi, Landsberg, Greg, Liem, Sebastian, Lin, Tongyan, Lowette, Steven, Lucas, Robyn, Malgeri, Luca, Malik, Sarah, McCabe, Christopher, Mete, Alaettin Serhan, Morgante, Enrico, Mrenna, Stephen, Nakahama, Yu, Newbold, Dave, Nordstrom, Karl, Pani, Priscilla, Papucci, Michele, Pataraia, Sophio, Penning, Bjoern, Pinna, Deborah, Polesello, Giacomo, Racco, Davide, Re, Emanuele, Riotto, Antonio Walter, Rizzo, Thomas, Salek, David, Sarkar, Subir, Schramm, Steven, Skubic, Patrick, Slone, Oren, Smirnov, Juri, Soreq, Yotam, Sumner, Timothy, Tait, Tim M. P., Thomas, Marc, Tomalin, Ian, Tunnell, Christopher, Vichi, Alessandro, Volansky, Tomer, Weiner, Neal, West, Stephen M., Wielers, Monika, Worm, Steven, Yavin, Itay, Zaldivar, Bryan, Zhou, Ning, and Zurek, Kathryn
- Subjects
High Energy Physics - Phenomenology - Abstract
This document outlines a set of simplified models for dark matter and its interactions with Standard Model particles. It is intended to summarize the main characteristics that these simplified models have when applied to dark matter searches at the LHC, and to provide a number of useful expressions for reference. The list of models includes both s-channel and t-channel scenarios. For s-channel, spin-0 and spin-1 mediation is discussed, and also realizations where the Higgs particle provides a portal between the dark and visible sectors. The guiding principles underpinning the proposed simplified models are spelled out, and some suggestions for implementation are presented., Comment: v3: Fixed typo in eqns 14 & 15
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- 2015
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34. Mapping monojet constraints onto Simplified Dark Matter Models
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Jacques, Thomas and Nordström, Karl
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment - Abstract
The move towards simplified models for Run II of the LHC will allow for stronger and more robust constraints on the dark sector. However there already exists a wealth of Run I data which should not be ignored in the run-up to Run II. Here we reinterpret public constraints on generic beyond-standard-model cross sections to place new constraints on a simplified model. We make use of an ATLAS search in the monojet $+$ missing energy channel to constrain a representative simplified model with the dark matter coupling to an axial-vector $Z'$. We scan the entire parameter space of our chosen model to set the strongest current collider constraints on our model using the full 20.3 fb$^{-1}$ ATLAS 8 TeV dataset and provide predictions for constraints that can be set with 20 fb$^{-1}$ of 14 TeV data. Our technique can also be used for the interpretation of Run II data and provides a broad benchmark for comparing future constraints on simplified models., Comment: 19 pages, 6 figures; v2: added references, corrected mistake in discussion of previous results; v3: major content additions, version accepted by JHEP
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- 2015
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35. Spectrum of neuroimaging findings post-proton beam therapy in a large pediatric cohort
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Bhattacharya, Debarata, Chhabda, Sahil, Lakshmanan, Rahul, Tan, Ronald, Warne, Richard, Benenati, Massimo, Michalski, Anthony, Aquilina, Kristian, Jacques, Thomas, Hargrave, Darren, Chang, Yen-Ching, Gains, Jenny, and Mankad, Kshitij
- Published
- 2021
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36. Risk factors for detection of SARS-CoV-2 in healthcare workers during April 2020 in a UK hospital testing programme
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Leeds, John S, Raviprakash, Veena, Jacques, Thomas, Scanlon, Noel, Cundall, Jeremy, and Leeds, Clare M
- Published
- 2020
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37. Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study
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Aichholzer, Martin, Amorim, Isabel, Aparicio, Javier, Aronica, Eleonora, Arzimanoglou, Alexis, Barba, Carmen, Beck, Jürgen, Becker, Albert, Beckervordersandforth, Jan C, Bien, Christian G, Blümcke, Ingmar, Bodi, Istvan, Braun, Kees PJ, Catenoix, Helene, Chassoux, Francine, Chipaux, Mathilde, Cloppenborg, Thomas, Coras, Roland, Cross, J Helen, De Palma, Luca, De Tisi, Jane, Deleo, Francesco, Devaux, Bertrand, Di Gennaro, Giancarlo, Dorfmüller, Georg, Duncan, John S, Elger, Christian, Ernst, Katharina, Esposito, Vincenzo, Feucht, Martha, Gadze, Zeljka Petelin, Garbelli, Rita, Geleijns, Karin, Gil-Nagel, Antonio, Grote, Alexander, Grunwald, Thomas, Guerrini, Renzo, Hamer, Hajo, Honavar, Mrinalini, Jacques, Thomas S, Jakovcevic, Antonia, Jutila, Leena, Kalina, Adam, Kälviäinen, Reetta, Klein, Karl Martin, Koenig, Kristina, Krsek, Pavel, Kudernatsch, Manfred, Kudr, Martin, Lamberink, Herm J, Malmgren, Kristina, Marusic, Petr, Melikyan, Armen, Menzler, Katja, Noachtar, Soheyl, Otte, Willem M, Özkara, Çiğdem, Pieper, Tom, Pimentel, Jose, Raicevic, Savo, Rheims, Sylvain, Ribeiro, Joana, Rosenow, Felix, Rössler, Karl, Rydenhag, Bertil, Sales, Francisco, San Antonio-Arce, Victoria, Schaller, Karl Lothar, Schijns, Olaf, Scholl, Theresa, Schramm, Johannes, Schulze-Bonhage, Andreas, Sciot, Raf, Seeck, Margitta, Shishkina, Lyudmila, Sokic, Dragoslav, Specchio, Nicola, Theys, Tom, Thom, Maria, Delgado, Rafael Toledano, Toulouse, Joseph, Uzan, Mustafa, van Loon, Johannes, Van Paesschen, Wim, von Oertzen, Tim J, Jansen, Floor, Leijten, Frans, van Rijen, Peter, Spliet, Wim GM, Mühlebner, Angelika, Kasper, Burkhard S, Fauser, Susanne, Polster, Tilman, Kalbhenn, Thilo, Delev, Daniel, McEvoy, Andrew, Miserocchi, Anna, Landré, Elisabeth, Turak, Bares, Varlet, Pascale, Ferrand-Sorbets, Sarah, Fohlen, Martine, Bulteau, Christine, Edelvik, Anna, Shah, Mukesch J, Scheiwe, Christian, Delicado, Eva Gutierrez, Tisdall, Martin, Eltze, Christin, Akkol, Serdar, Deniz, Kaancan, Oz, Buge, Holthausen, Hans, Hartlieb, Till, Staudt, Martin, Casciato, Sara, Quarato, Pier P, Giangaspero, Felice, Streichenberger, Nathalie, Guenot, Marc, Isnard, Jean, Valentijn, Antonio, Chang, Amanda, Mullatti, Nandini, Zamecnik, Josef, Zarubova, Jana, Tomasek, Martin, Immonen, Arto, Saarela, Anni, Rauramaa, Tuomas, Lobrinus, Johannes A, Egervari, Kristof, Momjian, Shahan, Harti, Elisabeth, Lohr, Hannah, Kroell, Judith, Vermeulen, Lynn, Cleeren, Evy, Vlasov, Pavel, Kozlova, Antonia, Vorobyev, Alexey, Goeppel, Gudrun, Samueli, Sharon, Czech, Thomas, Hainfellner, Johannes, Puttinger, Gertraud, Schwarz, Gabriele, Stefanits, Harald, Weis, Serge, Spreafico, Roberto, Villani, Flavio, Rossini, Laura, Hermsen, Anke, Knake, Susanne, Nimsky, Christopher, Carl, Barbara, Belohlavkova, Anezka, Benova, Barbora, Bisschop, Jeroen, Colon, Albert, van Kranen-Mastenbroek, Vivianne, Rouhl, Rob PW, Hoogland, Govert, Rumiá, Jordi, Ramírez-Camacho, Alia, Candela-Cantó, Santiago, Ostrowsky-Coste, Karine, Panagiotakaki, Eleni, Montavont, Alexandra, Kosal, Pascale Keo, Gokce-Samar, Zeynep, Milleret, Clara, Buccoliero, Anna M, Giordano, Flavio, Sulentic, Vlatko, Mrak, Goran, Desnica, Andrej, CarfíPavia, Giusy, De Benedictis, Alessandro, Marras, Carlo E, Bascarevic, Vladimir, Vojvodic, Nikola, Ristic, Aleksandar, Rebelo, Olinda, Aledo-Serrano, Angel, Garcia-Morales, Irene, Anciones, Carla, and Braun, Kees P J
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- 2020
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38. Consensus framework for conducting phase I/II clinical trials for children, adolescents, and young adults with pediatric low-grade glioma: Guidelines established by the International Pediatric Low-Grade Glioma Coalition Clinical Trial Working Group
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Mueller, Sabine, primary, Fangusaro, Jason, additional, Thomas, Arzu Onar, additional, Jacques, Thomas S, additional, Bandopadhayay, Pratiti, additional, de Blank, Peter, additional, Packer, Roger J, additional, Fouladi, Maryam, additional, van Meeteren, Antoinette Schouten, additional, Jones, David, additional, Perry, Arie, additional, Nakano, Yoshiko, additional, Hargrave, Darren, additional, Riedl, David, additional, Robinson, Nathan J, additional, Partanen, Marita, additional, Fisher, Michael J, additional, and Witt, Olaf, additional
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- 2023
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39. Making the Most of the Relic Density for Dark Matter Searches at the LHC 14 TeV Run
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Busoni, Giorgio, De Simone, Andrea, Jacques, Thomas, Morgante, Enrico, and Riotto, Antonio
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment - Abstract
As the LHC continues to search for new weakly interacting particles, it is important to remember that the search is strongly motivated by the existence of dark matter. In view of a possible positive signal, it is essential to ask whether the newly discovered weakly interacting particle can be be assigned the label "dark matter". Within a given set of simplified models and modest working assumptions, we reinterpret the relic abundance bound as a relic abundance range, and compare the parameter space yielding the correct relic abundance with projections of the Run II exclusion regions. Assuming that dark matter is within the reach of the LHC, we also make the comparison with the potential 5$\sigma$ discovery regions. Reversing the logic, relic density calculations can be used to optimize dark matter searches by motivating choices of parameters where the LHC can probe most deeply into the dark matter parameter space. In the event that DM is seen outside of the region giving the correct relic abundance, we will learn that either thermal relic DM is ruled out in that model, or the DM-quark coupling is suppressed relative to the DM coupling strength to other SM particles., Comment: 17 pages; Updated to match published version, fixed typos and added references
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- 2014
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40. Translating metagenomics into clinical practice for complex paediatric neurological presentations
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Penner, Justin, primary, Hassell, Jane, additional, Brown, Julianne R., additional, Mankad, Kshitij, additional, Storey, Nathaniel, additional, Atkinson, Laura, additional, Ranganathan, Nisha, additional, Lennon, Alexander, additional, Lee, Jack C.D., additional, Champsas, Dimitrios, additional, Kopec, Angelika, additional, Shah, Divya, additional, Venturini, Cristina, additional, Dixon, Garth, additional, De, Surjo, additional, Hatcher, James, additional, Harris, Kathryn, additional, Aquilina, Kristian, additional, Kusters, Maaike A., additional, Moshal, Karyn, additional, Shingadia, Delane, additional, Worth, Austen J.J., additional, Lucchini, Giovanna, additional, Merve, Ashirwad, additional, Jacques, Thomas S., additional, Bamford, Alasdair, additional, Kaliakatsos, Marios, additional, Breuer, Judith, additional, and Morfopoulou, Sofia, additional
- Published
- 2023
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41. Simplified Models for Dark Matter and Missing Energy Searches at the LHC
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Abdallah, Jalal, Ashkenazi, Adi, Boveia, Antonio, Busoni, Giorgio, De Simone, Andrea, Doglioni, Caterina, Efrati, Aielet, Etzion, Erez, Gramling, Johanna, Jacques, Thomas, Lin, Tongyan, Morgante, Enrico, Papucci, Michele, Penning, Bjoern, Riotto, Antonio Walter, Rizzo, Thomas, Salek, David, Schramm, Steven, Slone, Oren, Soreq, Yotam, Vichi, Alessandro, Volansky, Tomer, Yavin, Itay, Zhou, Ning, and Zurek, Kathryn
- Subjects
High Energy Physics - Phenomenology ,High Energy Physics - Experiment - Abstract
The study of collision events with missing energy as searches for the dark matter (DM) component of the Universe are an essential part of the extensive program looking for new physics at the LHC. Given the unknown nature of DM, the interpretation of such searches should be made broad and inclusive. This report reviews the usage of simplified models in the interpretation of missing energy searches. We begin with a brief discussion of the utility and limitation of the effective field theory approach to this problem. The bulk of the report is then devoted to several different simplified models and their signatures, including s-channel and t-channel processes. A common feature of simplified models for DM is the presence of additional particles that mediate the interactions between the Standard Model and the particle that makes up DM. We consider these in detail and emphasize the importance of their inclusion as final states in any coherent interpretation. We also review some of the experimental progress in the field, new signatures, and other aspects of the searches themselves. We conclude with comments and recommendations regarding the use of simplified models in Run-II of the LHC., Comment: v2. references added, version submitted to journal. v1. 47 pages, 13 plots
- Published
- 2014
42. On the Validity of the Effective Field Theory for Dark Matter Searches at the LHC Part III: Analysis for the $t$-channel
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Busoni, Giorgio, De Simone, Andrea, Jacques, Thomas, Morgante, Enrico, and Riotto, Antonio
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment - Abstract
We extend our recent analysis of the limitations of the effective field theory approach to studying dark matter at the LHC, by investigating the case in which Dirac dark matter couples to standard model quarks via $t$-channel exchange of a heavy scalar mediator. We provide analytical results for the validity of the effective field theory description, for both $\sqrt{s}$ = 8 TeV and 14 TeV. We make use of a MonteCarlo event generator to assess the validity of our analytical conclusions. We also point out the general trend that in the regions where the effective field theory is valid, the dark matter relic abundance is typically large., Comment: 15 pages, 8 figures. Updated to match published version. References, minor clarifications, and one figure added
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- 2014
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43. SUNY series, Humanities to the Rescue: Transatlantic Crossroads of a Critical Insurrection
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David R. Castillo, Jean-Jacques Thomas, Ewa Plonowska Ziarek and David R. Castillo, Jean-Jacques Thomas, Ewa Plonowska Ziarek
- Published
- 2021
44. Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course
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Wefers, Annika K., Stichel, Damian, Schrimpf, Daniel, Coras, Roland, Pages, Mélanie, Tauziède-Espariat, Arnault, Varlet, Pascale, Schwarz, Daniel, Söylemezoglu, Figen, Pohl, Ute, Pimentel, José, Meyer, Jochen, Hewer, Ekkehard, Japp, Anna, Joshi, Abhijit, Reuss, David E., Reinhardt, Annekathrin, Sievers, Philipp, Casalini, M. Belén, Ebrahimi, Azadeh, Huang, Kristin, Koelsche, Christian, Low, Hu Liang, Rebelo, Olinda, Marnoto, Dina, Becker, Albert J., Staszewski, Ori, Mittelbronn, Michel, Hasselblatt, Martin, Schittenhelm, Jens, Cheesman, Edmund, de Oliveira, Ricardo Santos, Queiroz, Rosane Gomes P., Valera, Elvis Terci, Hans, Volkmar H., Korshunov, Andrey, Olar, Adriana, Ligon, Keith L., Pfister, Stefan M., Jaunmuktane, Zane, Brandner, Sebastian, Tatevossian, Ruth G., Ellison, David W., Jacques, Thomas S., Honavar, Mrinalini, Aronica, Eleonora, Thom, Maria, Sahm, Felix, von Deimling, Andreas, Jones, David T. W., Blumcke, Ingmar, and Capper, David
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- 2020
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45. The Scientific Reach of Multi-Ton Scale Dark Matter Direct Detection Experiments
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Newstead, Jayden L., Jacques, Thomas D., Krauss, Lawrence M., Dent, James B., and Ferrer, Francesc
- Subjects
Astrophysics - Cosmology and Extragalactic Astrophysics ,High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
The next generation of large scale WIMP direct detection experiments have the potential to go beyond the discovery phase and reveal detailed information about both the particle physics and astrophysics of dark matter. We report here on early results arising from the development of a detailed numerical code modeling the proposed DARWIN detector, involving both liquid argon and xenon targets. We incorporate realistic detector physics, particle physics and astrophysical uncertainties and demonstrate to what extent two targets with similar sensitivities can remove various degeneracies and allow a determination of dark matter cross sections and masses while also probing rough aspects of the dark matter phase space distribution. We find that, even assuming dominance of spin-independent scattering, multi-ton scale experiments still have degeneracies that depend sensitively on the dark matter mass, and on the possibility of isospin violation and inelasticity in interactions. We find that these experiments are best able to discriminate dark matter properties for dark matter masses less than around 200 GeV. In addition, and somewhat surprisingly, the use of two targets gives only a small improvement (aside from the advantage of different systematics associated with any claimed signal) in the ability to pin down dark matter parameters when compared with one target of larger exposure., Comment: 23 pages; updated to match PRD version
- Published
- 2013
- Full Text
- View/download PDF
46. Additional Light Sterile Neutrinos and Cosmology
- Author
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Jacques, Thomas D., Krauss, Lawrence M., and Lunardini, Cecilia
- Subjects
Astrophysics - Cosmology and Extragalactic Astrophysics ,High Energy Physics - Phenomenology - Abstract
Tantalizing cosmological and terrestrial evidence suggests the number of light neutrinos may be greater than 3, motivating a careful re-examination of cosmological bounds on extra light species. Big Bang Nucleosynthesis constrains the number of relativistic neutrino species present during nucleosynthesis, $N_{eff}^{BBN}$, while measurements of the CMB angular power spectrum constrain the effective energy density in relativistic neutrinos at the time of matter-radiation equality, $N_{eff}^{CMB}$. There are a number of scenarios where new sterile neutrino species may have different contributions to $\Delta N_{eff}^{BBN}$ and $\Delta N_{eff}^{CMB}$, for masses that may be relevant to reconciling cosmological constraints with various terrestrial claims of neutrino oscillations. We consider a scenario with two sterile neutrinos and explore whether partial thermalization of the sterile states can ease the tension between cosmological constraints on $N_{eff}^{BBN}$ and terrestrial data. We then investigate the effect of a non-zero neutrino mass on their contribution to the radiation abundance, finding reductions in $\Delta N_{eff}^{CMB}$ of more than 5% for neutrinos with masses above 0.5 eV. While the effects we investigate here could play a role, we nevertheless find that two additional light sterile neutrinos species cannot fit all the data at the 95% confidence level., Comment: 9 pages, 3 figures; Version accepted for publication in Phys. Rev. D
- Published
- 2013
- Full Text
- View/download PDF
47. Searching for Dark Matter at the LHC with a Mono-Z
- Author
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Bell, Nicole F., Dent, James B., Galea, Ahmad J., Jacques, Thomas D., Krauss, Lawrence M., and Weiler, Thomas J.
- Subjects
High Energy Physics - Phenomenology - Abstract
We investigate a mono-Z process as a potential dark matter search strategy at the LHC. In this channel a single Z boson recoils against missing transverse momentum, attributed to dark matter particles, $\chi$, which escape the detector. This search strategy is related, and complementary to, monojet and monophoton searches. For illustrative purposes we consider the process $q\bar{q} -> \chi\chi Z$ in a toy dark matter model, where the Z boson is emitted from either the initial state quarks, or from the internal propagator. Among the signatures of this process will be a pair of muons with high pT that reconstruct to the invariant mass of the Z, and large amounts of missing transverse energy. Being a purely electroweak signal, QCD and other Standard Model backgrounds are relatively easily removed with modest selection cuts. We compare the signal to Standard Model backgrounds and demonstrate that, even for conservative cuts, there exist regions of parameter space where the signal may be clearly visible above background in future LHC data, allowing either new discovery potential or the possibility of supplementing information about the dark sector beyond that available from other observable channels., Comment: 11 pages, 13 figures
- Published
- 2012
- Full Text
- View/download PDF
48. Neutrino signals from electroweak bremsstrahlung in solar WIMP annihilation
- Author
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Bell, Nicole F., Brennan, Amelia J., and Jacques, Thomas D.
- Subjects
High Energy Physics - Phenomenology - Abstract
Bremsstrahlung of $W$ and $Z$ gauge bosons, or photons, can be an important dark matter annihilation channel. In many popular models in which the annihilation to a pair of light fermions is helicity suppressed, these bremsstrahlung processes can lift the suppression and thus become the dominant annihilation channels. The resulting dark matter annihilation products contain a large, energetic, neutrino component. We consider solar WIMP annihilation in the case where electroweak bremsstrahlung dominates, and calculate the resulting neutrino spectra. The flux consists of primary neutrinos produced in processes such as $\chi\chi\rightarrow \bar{\nu}\nu Z$ and $\chi\chi\rightarrow \bar{\nu}\ell W$, and secondary neutrinos produced via the decays of gauge bosons and charged leptons. After dealing with the neutrino propagation and flavour evolution in the Sun, we consider the prospects for detection in neutrino experiments on Earth. By comparing our signal with that for annihilation to $W^+W^-$, we show that the detection prospects for the bremsstrahlung annihilation channel are favourable., Comment: 18 pages, 5 figures. Discussion expanded; matches published version
- Published
- 2012
- Full Text
- View/download PDF
49. W/Z Bremsstrahlung as the Dominant Annihilation Channel for Dark Matter, Revisited
- Author
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Bell, Nicole F., Dent, James B., Galea, Ahmad J., Jacques, Thomas D., Krauss, Lawrence M., and Weiler, Thomas J.
- Subjects
High Energy Physics - Phenomenology ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We revisit the calculation of electroweak bremsstrahlung contributions to dark matter annihilation. Dark matter annihilation to leptons is necessarily accompanied by electroweak radiative corrections, in which a $W$ or $Z$ boson is also radiated. Significantly, while many dark matter models feature a helicity suppressed annihilation rate to fermions, bremsstrahlung process can remove this helicity suppression such that the branching ratios Br($\ell \nu W $), Br($\ell^+\ell^-Z$), and Br($\bar\nu \nu Z$) dominate over Br($\ell^+\ell^-$) and Br($\bar\nu \nu$). We find this is most significant in the limit where the dark matter mass is nearly degenerate with the mass of the boson which mediates the annihilation process. Electroweak bremsstrahlung has important phenomenological consequences both for the magnitude of the total dark matter annihilation cross section and for the character of the astrophysical signals for indirect detection. Given that the $W$ and $Z$ gauge bosons decay dominantly via hadronic channels, it is impossible to produce final state leptons without accompanying protons, antiprotons, and gamma rays., Comment: 8 pages, 6 figures; replaced to match published version
- Published
- 2011
- Full Text
- View/download PDF
50. Dark Matter Annihilation Signatures from Electroweak Bremsstrahlung
- Author
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Bell, Nicole F., Dent, James B., Jacques, Thomas D., and Weiler, Thomas J.
- Subjects
High Energy Physics - Phenomenology ,Astrophysics - Cosmology and Extragalactic Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We examine observational signatures of dark matter annihilation in the Milky Way arising from electroweak bremsstrahlung contributions to the annihilation cross section. It has been known for some time that photon bremsstrahlung may significantly boost DM annihilation yields. Recently, we have shown that electroweak bremsstrahlung of W and Z gauge bosons can be the dominant annihilation channel in some popular models with helicity-suppressed 2 --> 2 annihilation. W/Z-bremsstrahlung is particularly interesting because the gauge bosons produced via annihilation subsequently decay to produce large correlated fluxes of electrons, positrons, neutrinos, hadrons (including antiprotons) and gamma rays, which are all of importance in indirect dark matter searches. Here we calculate the spectra of stable annihilation products produced via gamma/W/Z-bremsstrahlung. After modifying the fluxes to account for the propagation through the Galaxy, we set upper bounds on the annihilation cross section via a comparison with observational data. We show that stringent cosmic ray antiproton limits preclude a sizable dark matter contribution to observed cosmic ray positron fluxes in the class of models for which the bremsstrahlung processes dominate., Comment: 11 pages, 6 figures. Updated to match PRD version
- Published
- 2011
- Full Text
- View/download PDF
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