1. Cutaneous pigmentation related to intravenous iron extravasation: Analysis from the French pharmacovigilance database
- Author
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Nadine Petitpain, Pierre Gillet, Alexia Hermitte-Gandoliere, Marion Lepelley, Jacqueline Ponte Astoul, Christine Le Beller, Laure Thomas, Service de pharmacie [CHR de Metz-Thionville], Centre hospitalier régional Metz-Thionville (CHR Metz-Thionville), Centre Régional de PharmacoVigilance de Lorraine (CRPV Lorraine), CRHU Nancy, Centre régional de pharmacovigilance de Grenoble [CHU Grenoble], Centre Hospitalier Universitaire [Grenoble] (CHU), Centre régional de pharmacovigilance [CHU Henri-Mondor], CHU Henri Mondor, Department of pharmacovigilance, Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre régional de pharmacovigilance de Marseille Provence Corse [CHU de Marseille] (CRPV-Marseille), CHU Marseille-Assistance Publique-Hôpitaux de Marseille (AP-HM), Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
medicine.medical_specialty ,Necrosis ,business.industry ,Extravasation IronSkin pigmentation ,Intravenous iron ,Dermatology ,Extravasation ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,Pharmacovigilance ,medicine ,Pharmacology (medical) ,030212 general & internal medicine ,medicine.symptom ,business ,ComputingMilieux_MISCELLANEOUS ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,030217 neurology & neurosurgery - Abstract
Summary Introduction Intravenous iron infusion may be complicated by extravasation and lead to cutaneous pigmentation. Methods We queried the French pharmacovigilance database to assess the spontaneously reported cases over the 2000–2016 period. Results Fifty-one cases of cutaneous pigmentation related to intravenous iron extravasation were retrieved, none was associated to necrosis. Most of patients were women aged 20 to 49 years old. The pigmentation was mostly a brown coloration, persisting over one month in 19 cases (37.2%) and over 6 months in 9 cases (17.6%). The management of extravasation and pigmentation was heterogeneous and was rarely followed by a decrease of the coloration. Conclusion Cutaneous pigmentation after intravenous iron extravasation can persist over time and create an aesthetic prejudice, particularly in young women. Standardized extravasation and iron-induced pigmentation management procedures appear necessary.
- Published
- 2018
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