1. Vasodilatory properties of recombinant maxadilan
- Author
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Jackson, Terence S., Lerner, Ethan, Weisbrod, Robert M., Tajima, Masahiro, Loscalzo, Joseph, and Keaney, John F., Jr.
- Subjects
Vasodilators -- Physiological aspects ,Smooth muscle -- Physiological aspects ,Rabbits -- Physiological aspects ,Biological sciences - Abstract
Maxadilan is a potent vasodilator suggested to share pharmacological and immunological properties with the calcitonin gene-related peptide. Exposure of vessels from isolated rabbit thoracic and abdominal aorta, carotid artery and iliac artery caused dose-dependent and endothelium-independent arterial relaxation. Pharmacological probes revealed that maxadilan-mediated arterial relaxation involved the activation of adenosine 3',5'-cyclic monophosphate but was inhibited by protein kinase A inhibitor H-89.
- Published
- 1996