31 results on '"Jackson, Paul J. M."'
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2. Introduction to Antibody–Drug Conjugates (ADCs)
3. Pyridinobenzodiazepines (PDDs) as Sequence-selective DNA Mono-alkylating Antibody–Drug Conjugate (ADC) Payloads
4. Use of Molecular Modelling Techniques in Antibody–Drug Conjugate (ADC) Payload Discovery and Development
5. Computational Approaches in the Development of Small-molecule Transcription Factor Inhibitors
6. A Novel Antibody-Drug Conjugate (ADC) Delivering a DNA Mono-Alkylating Payload to Chondroitin Sulfate Proteoglycan (CSPG4)-Expressing Melanoma
7. Abstract C030: A new low potency DNA guanine monoalkylating ADC payload with enhancedin vivotolerability
8. From Anthramycin to Pyrrolobenzodiazepine (PBD)‐Containing Antibody–Drug Conjugates (ADCs)
9. Entwicklung Pyrrolobenzodiazepin(PBD)-haltiger Antikörper-Wirkstoff-Konjugate (ADCs) ausgehend von Anthramycin
10. Abstract 4778: Covalent bonding of a C8-conjugated pyrrolobenzodiazepine (PBD) monomer and dimer to a terminal guanine residue of DNA duplex and hairpin fragments
11. Abstract 4779: In silico design, synthesis and evaluation of a new family of C1-substituted pyrrolobenzodiazepines (PBDs)
12. Abstract 1357: In silico design and biological evaluation of benzofused polyamides targeting G-quadruplex DNA structures
13. Covalent Bonding of Pyrrolobenzodiazepines (PBDs) to Terminal Guanine Residues within Duplex and Hairpin DNA Fragments
14. Abstract 3696: Molecular dynamics simulations of C7/C7′-linked pyrrolobenzodiazepine (PBD) dimers
15. Abstract 4555: C8-linked pyrrolobenzodiazepine (PBD)-benzofused hybrids as transcription factor inhibitors
16. Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells
17. Effect of hairpin loop structure on reactivity, sequence preference and adduct orientation of a DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumour agent
18. Entwicklung Pyrrolobenzodiazepin(PBD)-haltiger Antikörper-Wirkstoff-Konjugate (ADCs) ausgehend von Anthramycin.
19. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs).
20. The use of molecular dynamics simulations to evaluate the DNA sequence-selectivity of G-A cross-linking PBD-duocarmycin dimers.
21. Abstract 5329: Molecular dynamics simulations of sibiromycin suggest a role for the c7-sugar in transcription factor inhibition
22. Pyrrolobenzodiazepines (PBDs) Do Not Bind to DNA G-Quadruplexes
23. Computational Studies Support the Role of the C7-Sibirosamine Sugar of the Pyrrolobenzodiazepine (PBD) Sibiromycin in Transcription Factor Inhibition
24. An Extended Pyrrolobenzodiazepine–Polyamide Conjugate with Selectivity for a DNA Sequence Containing the ICB2 Transcription Factor Binding Site
25. Abstract 4549: Use of molecular dynamic simulations to explore changes in conformation and sequence preference for DNA-binding biaryl polyamide structures.
26. GC-Targeted C8-Linked Pyrrolobenzodiazepine–Biaryl Conjugates with Femtomolar in Vitro Cytotoxicity and in Vivo Antitumor Activity in Mouse Models
27. GC-TargetedC8-Linked Pyrrolobenzodiazepine–BiarylConjugates with Femtomolar in Vitro Cytotoxicity and in Vivo AntitumorActivity in Mouse Models.
28. UPLC-based assay to assess the hydrophobicity of Antibody-Drug Conjugate (ADC) payloads.
29. Use of pyrrolobenzodiazepines and related covalent-binding DNA-interactive molecules as ADC payloads: Is mechanism related to systemic toxicity?
30. Sequence-selective binding of C8-conjugated pyrrolobenzodiazepines (PBDs) to DNA.
31. Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry.
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