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7. The Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Ivacaftor Augments Mucociliary Clearance Abrogating Cystic Fibrosis Transmembrane Conductance Regulator Inhibition by Cigarette Smoke

Author

Raju, Vamsee S., Lin, Vivian Y., Liu, Limbo, McNicholas, Carmel M., Karki, Suman, Sloane, Peter A., Tang, Liping, Jackson, Patricia L., Wang, Wei, Wilson, Landon, Macon, Kevin J., Mazur, Marina, Kappes, John C., DeLucas, Lawrence J., Barnes, Stephen, Kirk, Kevin, Tearney, Guillermo J., and Rowe, Steven M.

Published
2017
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15. A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation

Author

Weathington, Nathaniel M, van Houwelingen, Anneke H, Noerager, Brett D, Jackson, Patricia L, Kraneveld, Aletta D, Galin, F Shawn, Folkerts, Gert, Nijkamp, Frans P, and Blalock, J Edwin

Abstract

We describe the tripeptide neutrophil chemoattractant N-acetyl Pro-Gly-Pro (PGP), derived from the breakdown of extracellular matrix (ECM), which shares sequence and structural homology with an important domain on alpha chemokines. PGP caused chemotaxis and production of superoxide through CXC receptors, and administration of peptide caused recruitment of neutrophils (PMNs) into lungs of control, but not CXCR2-deficient mice. PGP was generated in mouse lung after exposure to lipopolysaccharide, and in vivo and in vitro blockade of PGP with monoclonal antibody suppressed PMN responses as much as chemokine-specific monoclonal antibody. Extended PGP treatment caused alveolar enlargement and right ventricular hypertrophy in mice. PGP was detectable in substantial concentrations in a majority of bronchoalveolar lavage samples from individuals with chronic obstructive pulmonary disease, but not control individuals. Thus, PGP's activity links degradation of ECM with neutrophil recruitment in airway inflammation, and PGP may be a biomarker and therapeutic target for neutrophilic inflammatory diseases., Author(s): Nathaniel M Weathington [1]; Anneke H van Houwelingen [2]; Brett D Noerager [1]; Patricia L Jackson [1]; Aletta D Kraneveld [2]; F Shawn Galin [1]; Gert Folkerts [2]; Frans [...]

Published
2006
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17. Solution structure of an insect-specific neurotoxin from the New World scorpion Centruroides sculpturatus Ewing

Author

Jablonsky, Michael J., Jackson, Patricia L., and Krishna, N. Rama

Subjects
Biochemistry -- Research, Neurotoxic agents -- Research, Nuclear magnetic resonance spectroscopy -- Usage, Proteins -- Research, Scorpions -- Venom, Sodium channels -- Research, Biological sciences, Chemistry
Abstract

Research has been conducted on the neurotoxic protein from New World scorpion Centruroides sculpturatus Ewing. The high-resolution solution structure of this protein has been identified via (super)1 H NMR spectroscopy.

Published
2001

19. Peanut allergy: an increasing health risk for children. (Primary Care Approaches)

Author

Jackson, Patricia L.

Subjects
Food allergy in children, Peanuts -- Health aspects, Peanut allergy -- Care and treatment
Abstract

Matthew, age 24 months, is brought into the clinic by his frantic mother. She reports Matthew started wheezing and broke out in a blotchy skin rash within 5 minutes of eating a cracker with peanut butter. Matthew has a history of mild, intermittent asthma treated with nebulized albuterol, which the mother administered without improvement in the child's breathing pattern. He also has a history of moderate atopic dermatitis and a prior milk intolerance that he has since outgrown. No other food allergies are noted in his history, and the mother believes this is the first time Matthew has eaten peanut butter. It has been approximately fi hour since he ingested the peanut butter. Matthew's vital signs are temperature 98.6[degrees]F, pulse 90, and respirations 60 with audible wheezing and repetitive cough. His blood pressure is 80/60. His face and chest are flushed with urticaria, and some swelling is noted around his mouth., Significance of Peanut Allergies Food allergies cause about 30,000 anaphylactic reactions and 200 deaths each year in the United States (Sampson, 1999). Peanut and tree nut allergies account for the [...]

Published
2002

21. Healthy people 2010 objective: reduce number ad frequency of courses of antibiotics for ear infections in young children. (Primary Care Approaches)

Author

Jackson, Patricia L.

Subjects
Pediatric nursing -- Research, Streptococcus pneumoniae -- Care and treatment, Acute otitis media -- Care and treatment, Children -- Diseases
Abstract

In the late 1990s a task force composed of experts in the management of acute otitis media (AOM) and the Drug-Resistant Streptococcus Pneumoniae Therapeutic Working Group were brought together to [...]

Published
2001

23. N-α-PGP and PGP, potential biomarkers and therapeutic targets for COPD

Author

Gaggar Amit, Dransfield Mark, Parker Suzanne, Noerager Brett, Jackson Patricia L, O'Reilly Philip, and Blalock J Edwin

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Chronic obstructive pulmonary disease (COPD) is a common respiratory disorder for which new diagnostic and therapeutic approaches are required. Hallmarks of COPD are matrix destruction and neutrophilic airway inflammation in the lung. We have previously described two tri-peptides, N-α-PGP and PGP, which are collagen fragments and neutrophil chemoattractants. In this study, we investigate if N-α-PGP and PGP are biomarkers and potential therapeutic targets for COPD. Methods Induced sputum samples from COPD patients, healthy controls and asthmatics were examined for levels of N-α-PGP and PGP using mass spectrometry and for the ability to generate PGP de novo from collagen. Proteases important in PGP generation in the lung were identified by the use of specific inhibitors in the PGP generation assay and by instillation of proteases into mouse lungs. Serum levels of PGP were compared between COPD patients and controls. Results N-α-PGP was detected in most COPD sputum samples but in no asthmatics or controls. PGP was detected in a few controls and in all COPD sputum samples, where it correlated with levels of myeloperoxidase. COPD sputum samples had the ability to generate N-α-PGP and PGP de novo from collagen. PGP generation by COPD sputum was blocked by inhibitors of matrix metalloproteases (MMP's) 1 and 9 and prolyl endopeptidase. MMP's 1 and 9 and prolyl endopeptidase acted synergistically to generate PGP in vivo when instilled into mouse lungs. Serum levels of PGP were also significantly higher in COPD patients than in controls Conclusion N-α-PGP and PGP may represent novel diagnostic tests and biomarkers for COPD. Inhibition of this pathway may provide novel therapies for COPD directed at the chronic, neutrophilic, airway inflammation which underlies disease progression.

Published
2009
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24. An in-depth investigation of 40 stairway accidents and the stair safety literature

Author

Jackson, Patricia L. and Cohen, H. Harvey

Subjects
Stairs -- Accidents, Safety factor in engineering -- Research, Transportation industry
Abstract

The result of an investigation on 40 stairway accidents shows that the most important problem associated with the stairway accident comes from the dimensional inconsistency of the stairways and not from the individual. The stair characteristics are designated in the study as including location, physical aspects and and external factors and the dimensional factors are defined as riser heights, tread depth, handrail measurements, stairway width, lighting measurements and coefficient of friction measurements. Stairway accidents can be reduced by improved design, construction, maintenance and use of stairways.

Published
1995

27. Macrophage Rac2 Is Required to Reduce the Severity of Cigarette Smoke–induced Pneumonia

Author

Larson-Casey, Jennifer L., primary, Gu, Linlin, additional, Jackson, Patricia L., additional, Briles, David E., additional, Hale, Joanetha Y., additional, Blalock, J. Edwin, additional, Wells, J. Michael, additional, Deshane, Jessy S., additional, Wang, Yong, additional, Davis, Dana, additional, Antony, Veena B., additional, Massicano, Adriana V. F., additional, Lapi, Suzanne E., additional, and Carter, A. Brent, additional

Published
2018
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28. The neutrophil chemoattractant peptide proline-glycine-proline is associated with acute respiratory distress syndrome

Author

Sharma, Nirmal S., primary, Lal, Charitharth Vivek, additional, Li, Jin-dong, additional, Lou, Xiang-yang, additional, Viera, Liliana, additional, Abdallah, Tarek, additional, King, Robert W., additional, Sethi, Jaskaran, additional, Kanagarajah, Prashanth, additional, Restrepo-Jaramillo, Ricardo, additional, Sales-Conniff, Amanda, additional, Wei, Shi, additional, Jackson, Patricia L., additional, Blalock, J. Edwin, additional, Gaggar, Amit, additional, and Xu, Xin, additional

Published
2018
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29. An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness

Author

Patel, Dhiren F., primary, Peiró, Teresa, additional, Shoemark, Amelia, additional, Akthar, Samia, additional, Walker, Simone A., additional, Grabiec, Aleksander M., additional, Jackson, Patricia L., additional, Hussell, Tracy, additional, Gaggar, Amit, additional, Xu, Xin, additional, Trevor, Jennifer L., additional, Li, Jindong, additional, Steele, Chad, additional, Tavernier, Gael, additional, Blalock, J. Edwin, additional, Niven, Robert M., additional, Gregory, Lisa G., additional, Simpson, Angela, additional, Lloyd, Clare M., additional, and Snelgrove, Robert J., additional

Published
2018
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32. Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosis

Author

O’Reilly, Philip J., primary, Ding, Qiang, additional, Akthar, Samia, additional, Cai, Guoqiang, additional, Genschmer, Kristopher R., additional, Patel, Dhiren F., additional, Jackson, Patricia L., additional, Viera, Liliana, additional, Roda, Mojtaba, additional, Locy, Morgan L., additional, Bernstein, Ellen A., additional, Lloyd, Clare M., additional, Bernstein, Kenneth E., additional, Snelgrove, Robert J., additional, and Blalock, J. Edwin, additional

Published
2017
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35. The matrikine N-α-PGP couples extracellular matrix fragmentation to endothelial permeability

Author

Hahn, Cornelia S, Scott, David W, Xu, Xin, Roda, Mojtaba Abdul, Payne, Gregory A, Wells, J Michael, Viera, Liliana, Winstead, Colleen J, Bratcher, Preston, Sparidans, Rolf W, Redegeld, Frank A, Jackson, Patricia L, Folkerts, Gert, Blalock, J Edwin, Patel, Rakesh P, Gaggar, Amit, Sub Immunopharmacology, Sub Airway in vivo Pharmacology, Sub Medicinal Chemistry & Chemical biol., Sub Clinical Pharmacology, and Pharmacology

Subjects
Pathology, medicine.medical_specialty, Endothelium, Cells, Inflammation, Extracellular matrix, 03 medical and health sciences, 0302 clinical medicine, Medicine, CXC chemokine receptors, Health and Medicine, Fragmentation (cell biology), Receptor, Research Articles, 030304 developmental biology, 0303 health sciences, Multidisciplinary, business.industry, fungi, food and beverages, SciAdv r-articles, respiratory system, Cell biology, respiratory tract diseases, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Paracellular transport, Systemic administration, medicine.symptom, business, Research Article
Abstract

Organ tissue breakdown can induce vascular leak in lung injury., The compartmentalization and transport of proteins and solutes across the endothelium is a critical biologic function altered during inflammation and disease, leading to pathology in multiple disorders. The impact of tissue damage and subsequent extracellular matrix (ECM) fragmentation in regulating this process is unknown. We demonstrate that the collagen-derived matrikine acetylated proline-glycine-proline (N-α-PGP) serves as a critical regulator of endothelial permeability. N-α-PGP activates human endothelial cells via CXC-chemokine receptor 2 (CXCR2), triggering monolayer permeability through a discrete intracellular signaling pathway. In vivo, N-α-PGP induces local vascular leak after subcutaneous administration and pulmonary vascular permeability after systemic administration. Furthermore, neutralization of N-α-PGP attenuates lipopolysaccharide-induced lung leak. Finally, we demonstrate that plasma from patients with acute respiratory distress syndrome (ARDS) induces VE-cadherin phosphorylation in human endothelial cells, and this activation is attenuated by N-α-PGP blockade with a concomitant improvement in endothelial monolayer impedance. These results identify N-α-PGP as a novel ECM-derived matrikine regulating paracellular permeability during inflammatory disease and demonstrate the potential to target this ligand in various disorders characterized by excessive matrix turnover and vascular leak such as ARDS.

Published
2015

36. Tristetraprolin Down-Regulation Contributes to Persistent TNF-Alpha Expression Induced by Cigarette Smoke Extract through a Post-Transcriptional Mechanism

Author

Zhao, Xue-Ke, primary, Che, Pulin, additional, Cheng, Ming-Liang, additional, Zhang, Quan, additional, Mu, Mao, additional, Li, Hong, additional, Luo, Yuan, additional, Liang, Yue-Dong, additional, Luo, Xin-Hua, additional, Gao, Chang-Qing, additional, Jackson, Patricia L., additional, Wells, J. Michael, additional, Zhou, Yong, additional, Hu, Meng, additional, Cai, Guoqiang, additional, Thannickal, Victor J., additional, Steele, Chad, additional, Blalock, J. Edwin, additional, Han, Xiaosi, additional, Chen, Ching-Yi, additional, and Ding, Qiang, additional

Published
2016
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37. Targeting prolyl endopeptidase with valproic acid as a potential modulator of neutrophilic inflammation

Author

Abdul Roda, Mojtaba, Sadik, Mariam, Gaggar, Amit, Hardison, Matthew T, Jablonsky, Michael J, Braber, Saskia, Blalock, James Edwin, Redegeld, Frank A, Folkerts, Gert, Jackson, Patricia L, Sub Airway in vivo Pharmacology, Sub General Pharmacology, LS Pharma, Sub Immunopharmacology, Pharmacology, Sub Airway in vivo Pharmacology, Sub General Pharmacology, LS Pharma, Sub Immunopharmacology, and Pharmacology

Subjects
Pulmonology, Neutrophils, Epidemiology, Psychopharmacology, lcsh:Medicine, Peptide, Drug Addiction, Pharmacology, Protein Structure, Secondary, Recreational Drug Addiction, Mice, Pulmonary Disease, Chronic Obstructive, Smoke, Medicine and Health Sciences, Psychology, Theoretical Pharmacology, lcsh:Science, chemistry.chemical_classification, Valproic Acid, Multidisciplinary, Serine Endopeptidases, Animal Models, 3. Good health, Biochemistry, lipids (amino acids, peptides, and proteins), Female, Collagen, medicine.symptom, Prolyl Oligopeptidases, medicine.drug, Research Article, Serine Proteinase Inhibitors, Chronic Obstructive Pulmonary Disease, Addiction, Inflammation, Mouse Models, Interstitial Lung Diseases, Research and Analysis Methods, Model Organisms, Prolyl endopeptidase, In vivo, Tobacco, medicine, Animals, Humans, Pharmacokinetics, Pharmacoepidemiology, lcsh:R, Biology and Life Sciences, Chemotaxis, In vitro, Enzyme, chemistry, Pharmacodynamics, lcsh:Q, Clinical Medicine
Abstract

A novel neutrophil chemoattractant derived from collagen, proline-glycine-proline (PGP), has been recently characterized in chronic obstructive pulmonary disease (COPD). This peptide is derived via the proteolytic activity of matrix metalloproteases (MMP's)-8/9 and PE, enzymes produced by neutrophils and present in COPD serum and sputum. Valproic acid (VPA) is an inhibitor of PE and could possibly have an effect on the severity of chronic inflammation. Here the interaction site of VPA to PE and the resulting effect on the secondary structure of PE is investigated. Also, the potential inhibition of PGP-generation by VPA was examined in vitro and in vivo to improve our understanding of the biological role of VPA. UV- visible, fluorescence spectroscopy, CD and NMR were used to determine kinetic information and structural interactions between VPA and PE. In vitro, PGP generation was significantly inhibited by VPA. In vivo, VPA significantly reduced cigarette-smoke induced neutrophil influx. Investigating the molecular interaction between VPA and PE showed that VPA modified the secondary structure of PE, making substrate binding at the catalytic side of PE impossible. Revealing the molecular interaction VPA to PE may lead to a better understanding of the involvement of PE and PGP in inflammatory conditions. In addition, the model of VPA interaction with PE suggests that PE inhibitors have a great potential to serve as therapeutics in inflammatory disorders.

Published
2013

38. Healthy People 2010: The Pediatric Nursing Challenge for the Next Decade

Author

Jackson, Patricia L.

Subjects
United States. Department of Health and Human Services -- Reports, Pediatric nursing -- Practice, Health planning -- Planning
Abstract

In January 2000 the U.S. Department of Health and Human Services released the Healthy People 2010 document titled "Healthy People in Healthy Communities" (http://www.health.gov/healthypeopie/). This informative and well-referenced document builds [...]

Published
2001

40. A Novel Proteolytic Cascade Generates an Extracellular Matrix-Derived Chemoattractant in Chronic Neutrophilic Inflammation1,2

Author

Gaggar, Amit, Jackson, Patricia L., Noerager, Brett D., O’Reilly, Philip J., McQuaid, D. Brent, Rowe, Steven M., Clancy, J. P., and Blalock, J. Edwin

Subjects
Inflammation, Extracellular Matrix Proteins, Chemotactic Factors, Cystic Fibrosis, Proline, Neutrophils, Serine Endopeptidases, Sputum, Article, Neutrophil Activation, Receptors, Interleukin-8B, Extracellular Matrix, Receptors, Interleukin-8A, Chemotaxis, Leukocyte, Mice, Matrix Metalloproteinase 8, Matrix Metalloproteinase 9, Chronic Disease, Animals, Humans, Prolyl Oligopeptidases, Oligopeptides
Abstract

Chronic neutrophilic inflammation is a manifestation of a variety of lung diseases including cystic fibrosis (CF). There is increasing evidence that fragments of extracellular matrix proteins, such as collagen and elastin, play an important role in inflammatory cell recruitment to the lung in animal models of airway inflammation. Unfortunately, the association of these peptides with human disease and the identification of therapeutic targets directed toward these inflammatory pathways have remained elusive. In this study, we demonstrate that a novel extracellular matrix-derived neutrophil chemoattractant, proline-glycine-proline (PGP), acts through CXC receptors 1 and 2 on neutrophils, similar to N-acetylated proline-glycine-proline (N-alpha-PGP). We describe the specific multistep proteolytic pathway involved in PGP generation from collagen, involving matrix metalloproteases 8 and 9 and prolyl endopeptidase, a serine protease for which we identify a novel role in inflammation. PGP generation correlates closely with airway neutrophil counts after administration of proteases in vivo. Using CF as a model, we show that CF sputum has elevated levels of PGP peptides and that PGP levels decline during the course of CF inpatient therapy for acute pulmonary exacerbation, pointing to its role as a novel biomarker for this disease. Finally, we demonstrate that CF secretions are capable of generating PGP from collagen ex vivo and that this generation is significantly attenuated by the use of inhibitors directed toward matrix metalloprotease 8, matrix metalloprotease 9, or prolyl endopeptidase. These experiments highlight unique protease interactions with structural proteins regulating innate immunity and support a role for these peptides as novel biomarkers and therapeutic targets for chronic, neutrophilic lung diseases.

Published
2008

41. Potential Role of High-Mobility Group Box 1 in Cystic Fibrosis Airway Disease

Author

Hardison, Mathew, Livraghi, Alessandra, McQuaid, D. Brent, Noerager, Brett D., Blalock, J. Edwin, Abraham, Edward, Liu, Gang, Gaggar, Amit, Solomon, G. Martin, Sorscher, Eric J., Jackson, Patricia L., Clancy, J. P., Rowe, Steven M., and O'Neal, Wanda

Subjects
chemical and pharmacologic phenomena
Abstract

Rationale: High-mobility group box 1 (HMGB1) is a potent inflammatory mediator elevated in sepsis and rheumatoid arthritis, although its role in cystic fibrosis (CF) lung disease is unknown.

Published
2008
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42. Targeting prolyl endopeptidase with valproic acid as a potential modulator of neutrophilic inflammation

Author

Abdul Roda, Mojtaba, Sadik, Mariam, Gaggar, Amit, Hardison, Matthew T, Jablonsky, Michael J, Braber, Saskia, Blalock, James Edwin, Redegeld, Frank A, Folkerts, Gert, Jackson, Patricia L, Abdul Roda, Mojtaba, Sadik, Mariam, Gaggar, Amit, Hardison, Matthew T, Jablonsky, Michael J, Braber, Saskia, Blalock, James Edwin, Redegeld, Frank A, Folkerts, Gert, and Jackson, Patricia L

Abstract

A novel neutrophil chemoattractant derived from collagen, proline-glycine-proline (PGP), has been recently characterized in chronic obstructive pulmonary disease (COPD). This peptide is derived via the proteolytic activity of matrix metalloproteases (MMP's)-8/9 and PE, enzymes produced by neutrophils and present in COPD serum and sputum. Valproic acid (VPA) is an inhibitor of PE and could possibly have an effect on the severity of chronic inflammation. Here the interaction site of VPA to PE and the resulting effect on the secondary structure of PE is investigated. Also, the potential inhibition of PGP-generation by VPA was examined in vitro and in vivo to improve our understanding of the biological role of VPA. UV-visible, fluorescence spectroscopy, CD and NMR were used to determine kinetic information and structural interactions between VPA and PE. In vitro, PGP generation was significantly inhibited by VPA. In vivo, VPA significantly reduced cigarette-smoke induced neutrophil influx. Investigating the molecular interaction between VPA and PE showed that VPA modified the secondary structure of PE, making substrate binding at the catalytic side of PE impossible. Revealing the molecular interaction VPA to PE may lead to a better understanding of the involvement of PE and PGP in inflammatory conditions. In addition, the model of VPA interaction with PE suggests that PE inhibitors have a great potential to serve as therapeutics in inflammatory disorders.

Published
2014

43. Targeting prolyl endopeptidase with valproic acid as a potential modulator of neutrophilic inflammation

Author

Sub Airway in vivo Pharmacology, Sub General Pharmacology, LS Pharma, Sub Immunopharmacology, Pharmacology, Abdul Roda, Mojtaba, Sadik, Mariam, Gaggar, Amit, Hardison, Matthew T, Jablonsky, Michael J, Braber, Saskia, Blalock, James Edwin, Redegeld, Frank A, Folkerts, Gert, Jackson, Patricia L, Sub Airway in vivo Pharmacology, Sub General Pharmacology, LS Pharma, Sub Immunopharmacology, Pharmacology, Abdul Roda, Mojtaba, Sadik, Mariam, Gaggar, Amit, Hardison, Matthew T, Jablonsky, Michael J, Braber, Saskia, Blalock, James Edwin, Redegeld, Frank A, Folkerts, Gert, and Jackson, Patricia L

Published
2014

46. Correction: Cigarette Smoke-Induced Collagen Destruction; Key to Chronic Neutrophilic Airway Inflammation?

Author

Overbeek, Saskia A., primary, Braber, Saskia, additional, Koelink, Pim J., additional, Henricks, Paul A. J., additional, Mortaz, Esmaeil, additional, LoTam Loi, Adele T., additional, Jackson, Patricia L., additional, Garssen, Johan, additional, Wagenaar, Gerry T. M., additional, Timens, Wim, additional, Koenderman, Leo, additional, Blalock, J. Edwin, additional, Kraneveld, Aletta D., additional, and Folkerts, Gert, additional

Published
2013
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47. Collagen degradation and neutrophilic infiltration: a vicious circle in inflammatory bowel disease

Author

Koelink, Pim J, primary, Overbeek, Saskia A, additional, Braber, Saskia, additional, Morgan, Mary E, additional, Henricks, Paul A J, additional, Roda, Mojtaba Abdul, additional, Verspaget, Hein W, additional, Wolfkamp, Simone C, additional, te Velde, Anje A, additional, Jones, Caleb W, additional, Jackson, Patricia L, additional, Blalock, J Edwin, additional, Sparidans, Rolf W, additional, Kruijtzer, John A W, additional, Garssen, Johan, additional, Folkerts, Gert, additional, and Kraneveld, Aletta D, additional

Published
2013
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48. Cigarette Smoke-Induced Collagen Destruction; Key to Chronic Neutrophilic Airway Inflammation?

Author

Overbeek, Saskia A., primary, Braber, Saskia, additional, Koelink, Pim J., additional, Henricks, Paul A. J., additional, Mortaz, Esmaeil, additional, LoTam Loi, Adele T., additional, Jackson, Patricia L., additional, Garssen, Johan, additional, Wagenaar, Gerry T. M., additional, Timens, Wim, additional, Koenderman, Leo, additional, Blalock, J. Edwin, additional, Kraneveld, Aletta D., additional, and Folkerts, Gert, additional

Published
2013
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