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23 results on '"Jackson, Madeline"'

1. iPSC-based modeling of preeclampsia identifies epigenetic defects in extravillous trophoblast differentiation

Author

Morey, Robert, Bui, Tony, Cheung, Virginia Chu, Dong, Chen, Zemke, Joseph E, Requena, Daniela, Arora, Harneet, Jackson, Madeline G, Pizzo, Donald, Theunissen, Thorold W, and Horii, Mariko

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Regenerative Medicine, Stem Cell Research, Stem Cell Research - Induced Pluripotent Stem Cell - Human, Hypertension, Stem Cell Research - Induced Pluripotent Stem Cell, Pediatric, Contraception/Reproduction, Clinical Research, Genetics, Stem Cell Research - Nonembryonic - Human, Cardiovascular, Aetiology, 2.1 Biological and endogenous factors, Good Health and Well Being
Published
2024

2. Derivation of functional trophoblast stem cells from primed human pluripotent stem cells

Author

Soncin, Francesca, Morey, Robert, Bui, Tony, Requena, Daniela F, Cheung, Virginia Chu, Kallol, Sampada, Kittle, Ryan, Jackson, Madeline G, Farah, Omar, Chousal, Jennifer, Meads, Morgan, Pizzo, Donald, Horii, Mariko, Fisch, Kathleen M, and Parast, Mana M

Subjects
Biochemistry and Cell Biology, Biological Sciences, Pediatric, Stem Cell Research - Induced Pluripotent Stem Cell, Stem Cell Research, Stem Cell Research - Nonembryonic - Human, Regenerative Medicine, Stem Cell Research - Induced Pluripotent Stem Cell - Human, Stem Cell Research - Embryonic - Human, Underpinning research, 1.1 Normal biological development and functioning, Generic health relevance, Cell Differentiation, Female, Humans, Induced Pluripotent Stem Cells, Placenta, Pluripotent Stem Cells, Pregnancy, Trophoblasts, cytotrophoblast, naive pluripotent stem cells, placenta, primed pluripotent stem cells, trophoblast stem cells, Clinical Sciences, Biochemistry and cell biology
Abstract

Trophoblast stem cells (TSCs) have recently been derived from human embryos and early-first-trimester placenta; however, aside from ethical challenges, the unknown disease potential of these cells limits their scientific utility. We have previously established a bone morphogetic protein 4 (BMP4)-based two-step protocol for differentiation of primed human pluripotent stem cells (hPSCs) into functional trophoblasts; however, those trophoblasts could not be maintained in a self-renewing TSC-like state. Here, we use the first step from this protocol, followed by a switch to newly developed TSC medium, to derive bona fide TSCs. We show that these cells resemble placenta- and naive hPSC-derived TSCs, based on their transcriptome as well as their in vitro and in vivo differentiation potential. We conclude that primed hPSCs can be used to generate functional TSCs through a simple protocol, which can be applied to a widely available set of existing hPSCs, including induced pluripotent stem cells, derived from patients with known birth outcomes.

Published
2022

10. Supplemental Material, sj-docx-1-cat-10.1177_10760296211018510 - Slounase, a Batroxobin Containing Activated Factor X Effectively Enhances Hemostatic Clot Formation and Reducing Bleeding in Hypocoagulant Conditions in Mice

Author

Adili, Reheman, Jackson, Madeline, Stanger, Livia, Dai, Xiangrong, Li, Mandy, Li, Benjamin Xiaoyi, and Holinstat, Michael

Subjects
FOS: Clinical medicine, Cardiology, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental Material, sj-docx-1-cat-10.1177_10760296211018510 for Slounase, a Batroxobin Containing Activated Factor X Effectively Enhances Hemostatic Clot Formation and Reducing Bleeding in Hypocoagulant Conditions in Mice by Reheman Adili, Madeline Jackson, Livia Stanger, Xiangrong Dai, Mandy Li, Benjamin Xiaoyi Li and Michael Holinstat in Clinical and Applied Thrombosis/Hemostasis

Published
2021
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13. Land use, REDD+ and the status of wildlife populations in Yaeda Valley, northern Tanzania

Author

Kiffner, Christian, primary, Arndt, Zoe, additional, Foky, Trent, additional, Gaeth, Megan, additional, Gannett, Alex, additional, Jackson, Madeline, additional, Lellman, Georgie, additional, Love, Sophia, additional, Maroldi, Ana, additional, McLaughlin, Shane, additional, Skenandore, Bobbi, additional, von Euler, Sarah, additional, Zambrano, Zachary, additional, and Kissui, Bernard, additional

Published
2019
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14. Characterization of hemostasis in mice lacking the novel thrombosis susceptibility gene Slc44a2

Author

Tilburg, Julia, primary, Adili, Reheman, additional, Nair, Thankam S., additional, Hawley, Megan E., additional, Tuk, David C., additional, Jackson, Madeline, additional, Spronk, Henri M., additional, Versteeg, Henri H., additional, Carey, Thomas E., additional, van Vlijmen, Bart J.M., additional, Maracle, Chrissta X., additional, and Holinstat, Michael, additional

Published
2018
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18. Improving Rates of Influenza Vaccination Through Electronic Health Record Portal Messages, Interactive Voice Recognition Calls and Patient-Enabled Electronic Health Record Updates: Protocol for a Randomized Controlled Trial

Author

Cutrona, Sarah L, primary, Sreedhara, Meera, additional, Goff, Sarah L, additional, Fisher, Lloyd D, additional, Preusse, Peggy, additional, Jackson, Madeline, additional, Sundaresan, Devi, additional, Garber, Lawrence D, additional, and Mazor, Kathleen M, additional

Published
2016
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22. An Investigation into The Effect of Social Media on Body Image and Self-Esteem on British Women Aged 20-23

Author

Jackson, Madeline and Jackson, Madeline

Abstract

The purpose of this study is to examine the effects of social media on body image and self-esteem for British women aged 20-23. Literature on this topic has examined the effects of social media on body image and the effects of social media on self-esteem separately. Literature proving the negative effects of social media has mainly applied to Facebook – which is not often used by this demographic, hence the need for this study. The four main themes found in this study are; social media is damaging to vulnerable people, a bad aspect of social media is comparison, there is a need for a real and non- perfect life to be shown and the body positive movement and societal change go hand in hand. This study finds that the parts of social media that effect self-esteem and body image the most are; the fact that its image based, comparison with people similar to them and their previous self, the fact that perfect lives and people are portrayed and the editing of images. The effects of social media can be reduced by; showing real life on social media and by posting content that follow the body positive movement’s ideals. Therefore, this study shows practical ways that individuals and managers can help to reduce the negative effects of social media on body image and self-esteem. Finally, the body positive trend was found to have a positive impact on the self-esteem and body image of this demographic. And it was discovered that content that follows the ideas of the body positive movement and societal change and both needed to prevent the negative effects of social media.

23. iPSC-based modeling of preeclampsia identifies epigenetic defects in extravillous trophoblast differentiation.

Author

Morey R, Bui T, Cheung VC, Dong C, Zemke JE, Requena D, Arora H, Jackson MG, Pizzo D, Theunissen TW, and Horii M

Abstract

Preeclampsia (PE) is a hypertensive pregnancy disorder with increased risk of maternal and fetal morbidity and mortality. Abnormal extravillous trophoblast (EVT) development and function is considered to be the underlying cause of PE, but has not been previously modeled in vitro . We previously derived induced pluripotent stem cells (iPSCs) from placentas of PE patients and characterized abnormalities in formation of syncytiotrophoblast and responses to changes in oxygen tension. In this study, we converted these primed iPSC to naïve iPSC, and then derived trophoblast stem cells (TSCs) and EVT to evaluate molecular mechanisms underlying PE. We found that primed (but not naïve) iPSC-derived PE-EVT have reduced surface HLA-G, blunted invasive capacity, and altered EVT-specific gene expression. These abnormalities correlated with promoter hypermethylation of genes associated with the epithelial-mesenchymal transition pathway, specifically in primed-iPSC derived PE-EVT. Our findings indicate that abnormal epigenetic regulation might play a role in PE pathogenesis., Competing Interests: M.H. has initiated a process for filing a patent for the protocol used. T.W.T. is a consultant for Stately Bio, Inc., (© 2024 The Authors.)

Published
2024
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