3,212 results on '"Jackson, F."'
Search Results
2. Modelling dynamic pantograph loads with combined numerical analysis
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Jackson, F. F., Mishra, R., Rebelo, J. M., Santos, J., Antunes, P., Pombo, J., Magalhães, H., Wills, L., and Askill, M.
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- 2024
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3. Re-description of the genus Talanga Moore and the description of a new endemic species from Indonesia (Lepidoptera: Crambidae; Spilomelinae)
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Darmawan, Darmawan, Watung, Jackson F., Suwito, Awit, Narakusumo, Raden Pramesa, Encilia, Encilia, Qodri, Agmal, Dwibadra, Dhian, Peggie, Djunijanti, Ubaidillah, Rosichon, and Sutrisno, Hari
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- 2024
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4. Germline T cell receptor exchange results in physiological T cell development and function
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Rollins, Meagan R., Raynor, Jackson F., Miller, Ebony A., Butler, Jonah Z., Spartz, Ellen J., Lahr, Walker S., You, Yun, Burrack, Adam L., Moriarity, Branden S., Webber, Beau R., and Stromnes, Ingunn M.
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- 2023
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5. Drosophila noktochor regulates night sleep via a local mushroom body circuit
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Draper, Isabelle R., Roberts, Mary A., Gailloud, Matthew, and Jackson, F. Rob
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- 2024
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6. Machine learning analysis of the UK Biobank reveals prognostic and diagnostic immune biomarkers for polyneuropathy and neuropathic pain in diabetes
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Allwright, Michael, Karrasch, Jackson F., O'Brien, Jayden A., Guennewig, Boris, and Austin, Paul J.
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- 2023
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7. Germline T cell receptor exchange results in physiological T cell development and function
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Meagan R. Rollins, Jackson F. Raynor, Ebony A. Miller, Jonah Z. Butler, Ellen J. Spartz, Walker S. Lahr, Yun You, Adam L. Burrack, Branden S. Moriarity, Beau R. Webber, and Ingunn M. Stromnes
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Science - Abstract
The currently available transgenic T cell receptor (TCR) models represent high affinity antigen-TCR interactions. Authors here present an alternative approach to target an exogenous TCR into the physiological Trac locus in the germline of mice, which uncovers that the natural genomic context for TCRs can enhance the antigen sensitivity of lower affinity TCRs and enables the physiologic range of antigen-TCR interaction and a gene dosage dependent mechanism of central tolerance.
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- 2023
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8. Decavanadate interactions with the elements of the SARS-CoV-2 spike protein highlight the potential role of electrostatics in disrupting the infectivity cycle
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Favre, Daniel, Harmon, Jackson F., Zhang, Ali, Miller, Matthew S., and Kaltashov, Igor A.
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- 2022
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9. Management of Ocular Adnexal Trauma
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Lever, Jackson F., Barmettler, Anne, Levine, Mark R., Servat, J. Javier, editor, Black, Evan H., editor, Nesi, Frank A., editor, Gladstone, Geoffrey J., editor, and Calvano, Christopher J., editor
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- 2021
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10. Identification, separation by spiral high-speed counter-current chromatography, and quantification of 7-chloro-5-methyl-2H-1,4-benzothiazin-3(4H)-one, an impurity in the thioindigoid color additive D&C Red No. 30 and its lakes
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Weisz, Adrian, Perez-Gonzalez, Marianita, Wood, Jackson F., Ridge, Clark D., and Ito, Yoichiro
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- 2021
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11. Ultra-Luminous X-ray Sources in Haro 11 and the Role of X-ray Binaries in Feedback in Lyman-alpha Emitting Galaxies
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Prestwich, A. H., Jackson, F., Kaaret, P., Brorby, M., Roberts, T. P., Saar, S. H., and Yukita, M.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
Lyman Break Analogs (LBA) are local proxies of high-redshift Lyman Break Galaxies (LBG). Studies of nearby starbursts have shown that Lyman continuum and line emission are absorbed by dust and that the Lyman-alpha is resonantly scattered by neutral hydrogen. A source of feedback is required to prevent scattering and allow the Lyman-alpha emission to escape. There are two X-ray point sources embedded in the Lyman Break Analog (LBA) galaxy Haro 11. Haro 11 X-1 is an extremely luminous (L$_{X} \sim 10^{41}$ ergs s$^{-1}$), spatially compact source with a hard X-ray spectrum. Haro 11 X-1 is similar to the extreme Black Hole Binary (BHB) M82 X-1. The hard X-ray spectrum indicates Haro 11 X-1 may be a Black Hole Binary (BHB) in a low accretion state. The very high X-ray luminosity suggests an intermediate mass black hole that could be the seed for formation of a supermassive black hole. Source Haro 11 X-2 has an X-ray luminosity L$_{X} \sim 5\times10^{40}$ ergs s$^{-1}$ and a soft X-ray spectrum. This strongly suggests that Haro 11 X-2 is an X-ray binary in the ultra luminous state. Haro 11 X-2 is coincident with the star forming knot that is the source of the Lyman-alpha emission, raising the possibility that strong winds from X-ray binaries play an important part in injecting mechanical power into the Interstellar Medium (ISM), thus blowing away neutral material from the starburst region and allowing the Lyman-alpha to escape. We suggest that feedback from X-ray binaries may play a significant role in allowing Lyman-alpha emission to escape from galaxies in the early universe., Comment: Accepted for publication in Astrophysical Journal
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- 2015
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12. Distinct myeloid antigen-presenting cells dictate differential fates of tumor-specific CD8+ T cells in pancreatic cancer
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Adam L. Burrack, Zoe C. Schmiechen, Michael T. Patterson, Ebony A. Miller, Ellen J. Spartz, Meagan R. Rollins, Jackson F. Raynor, Jason S. Mitchell, Tsuneyasu Kaisho, Brian T. Fife, and Ingunn M. Stromnes
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Immunology ,Medicine - Abstract
We investigate how myeloid subsets differentially shape immunity to pancreatic ductal adenocarcinoma (PDA). We show that tumor antigenicity sculpts myeloid cell composition and functionality. Antigenicity promotes accumulation of type 1 dendritic cells (cDC1), which is driven by Xcr1 signaling, and overcomes macrophage-mediated suppression. The therapeutic activity of adoptive T cell therapy or programmed cell death ligand 1 blockade required cDC1s, which sustained splenic Klrg1+ cytotoxic antitumor T cells and functional intratumoral T cells. KLRG1 and cDC1 genes correlated in human tumors, and PDA patients with high intratumoral KLRG1 survived longer than patients with low intratumoral KLRG1. The immunotherapy CD40 agonist also required host cDC1s for maximal therapeutic benefit. However, CD40 agonist exhibited partial therapeutic benefit in cDC1-deficient hosts and resulted in priming of tumor-specific yet atypical CD8+ T cells with a regulatory phenotype and that failed to participate in tumor control. Monocyte/macrophage depletion using clodronate liposomes abrogated T cell priming yet enhanced the antitumor activity of CD40 agonist in cDC1-deficient hosts via engagement of innate immunity. In sum, our study supports that cDC1s are essential for sustaining effective antitumor T cells and supports differential roles for cDC1s and monocytes/macrophages in instructing T cell fate and immunotherapy response.
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- 2022
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13. Description of two new species in the genus Glyphodes Guenée from Indonesia (Lepidoptera: Crambidae, Spilomelinae)
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WATUNG, JACKSON F., primary, DARMAWAN, DARMAWAN, additional, SUWITO, AWIT, additional, NARAKUSUMO, RADEN PRAMESA, additional, NUGROHO, HARI, additional, ENCILIA, ENCILIA, additional, QODRI, AGMAL, additional, PEGGIE, DJUNIJANTI, additional, UBAIDILLAH, ROSICHON, additional, and SUTRISNO, HARI, additional
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- 2024
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14. A new endemic clove tree pest of Cryptophasa Lewin, from Sangihe Island, Indonesia (Lepidoptera: Xyloryctidae)
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WATUNG, JACKSON F, primary, TAIRAS, ROBERT W, additional, KALIGIS, JAMES B, additional, DARMAWAN, DARMAWAN, additional, SUWITO, AWIT, additional, NARAKUSUMO, RADEN PRAMESA, additional, ENCILIA, ENCILIA, additional, DWIBADRA, DHIAN, additional, DHARMAYANTHI, ANIK BUDHI, additional, and SUTRISNO, HARI, additional
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- 2024
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15. A deficit of ultraluminous X-ray sources in luminous infrared galaxies
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Luangtip, W., Roberts, T. P., Mineo, S., Lehmer, B. D., Alexander, D. M., Jackson, F. E., Goulding, A. D., and Fischer, J. L.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present results from a Chandra study of ultraluminous X-ray sources (ULXs) in a sample of 17 nearby (D_L<60 Mpc) luminous infrared galaxies (LIRGs), selected to have star formation rates (SFRs) in excess of 7 M_sun yr^-1 and low foreground Galactic column densities (N_H < 5*10^20 cm^-2). A total of 53 ULXs were detected and we confirm that this is a complete catalogue of ULXs for the LIRG sample. We examine the evolution of ULX spectra with luminosity by stacking the spectra of individual objects in three luminosity bins, finding a distinct change in spectral index at luminosity ~2 *10^39 erg s^-1. This may be a change in spectrum as 10 M_sun black holes transit from a ~Eddington to a super-Eddington accretion regime, and is supported by a plausible detection of partially-ionised absorption imprinted on the spectrum of the luminous ULX (L_X ~5*10^39 erg s^-1) CXOU J024238.9-000055 in NGC 1068, consistent with the highly ionised massive wind that we would expect to see driven by a super-Eddington accretion flow. This sample shows a large deficit in the number of ULXs detected per unit SFR (0.2 ULXs M_sun^-1 yr^-1). This deficit also manifests itself as a lower differential X-ray luminosity function normalisation for the LIRG sample than for samples of other star forming galaxies. We show that it is unlikely that this deficit is a purely observational effect. Part of this deficit might be attributable to the high metallicity of the LIRGs impeding the production efficiency of ULXs and/or a lag between the star formation starting and the production of ULXs; however, we argue that the evidence -- including very low N_ULX/L_FIR, and an even lower ULX incidence in the central regions of the LIRGs -- shows that the main culprit for this deficit is likely to be the high column of gas and dust in these galaxies, that fuels the high SFR but also acts to obscure many ULXs from our view., Comment: Accepted for publication in MNRAS; 26 pages, 6 figures, 12 tables
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- 2014
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16. The Physics of the B Factories
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Bevan, A. J., Golob, B., Mannel, Th., Prell, S., Yabsley, B. D., Abe, K., Aihara, H., Anulli, F., Arnaud, N., Aushev, T., Beneke, M., Beringer, J., Bianchi, F., Bigi, I. I., Bona, M., Brambilla, N., rodzicka, J. B, Chang, P., Charles, M. J., Cheng, C. H., Cheng, H. -Y., Chistov, R., Colangelo, P., Coleman, J. P., Drutskoy, A., Druzhinin, V. P., Eidelman, S., Eigen, G., Eisner, A. M., Faccini, R., Flood, K. T ., Gambino, P., Gaz, A., Gradl, W., Hayashii, H., Higuchi, T., Hulsbergen, W. D., Hurth, T., Iijima, T., Itoh, R., Jackson, P. D., Kass, R., Kolomensky, Yu. G., Kou, E., Križan, P., Kronfeld, A., Kumano, S., Kwon, Y. J., Latham, T. E., Leith, D. W. G. S., Lüth, V., Martinez-Vidal, F., Meadows, B. T., Mussa, R., Nakao, M., Nishida, S., Ocariz, J., Olsen, S. L., Pakhlov, P., Pakhlova, G., Palano, A., Pich, A., Playfer, S., Poluektov, A., Porter, F. C., Robertson, S. H., Roney, J. M., Roodman, A., Sakai, Y., Schwanda, C., Schwartz, A. J., Seidl, R., Sekula, S. J., Steinhauser, M., Sumisawa, K., Swanson, E. S., Tackmann, F., Trabelsi, K., Uehara, S., Uno, S., van der Water, R., Vasseur, G., Verkerke, W., Waldi, R., Wang, M. Z., Wilson, F. F., Zupan, J., Zupanc, A., Adachi, I., Albert, J., Banerjee, Sw., Bellis, M., Ben-Haim, E., Biassoni, P., Cahn, R. N., Cartaro, C., Chauveau, J., Chen, C., Chiang, C. C., Cowan, R., Dalseno, J., Davier, M., Davies, C., Dingfelder, J. C., nard, B. Eche, Epifanov, D., Fulsom, B. G., Gabareen, A. M., Gary, J. W., Godang, R., Graham, M. T., Hafner, A., Hamilton, B., Hartmann, T., Hayasaka, K., Hearty, C., Iwasaki, Y., Khodjamirian, A., Kusaka, A., Kuzmin, A., Lafferty, G. D., Lazzaro, A., Li, J., Lindemann, D., Long, O., Lusiani, A., Marchiori, G., Martinelli, M., Miyabayashi, K., Mizuk, R., Mohanty, G. B., Muller, D. R., Nakazawa, H., Ongmongkolkul, P., Pacetti, S., Palombo, F., Pedlar, T. K., Piilonen, L. E., Pilloni, A., Poireau, V., Prothmann, K., Pulliam, T., Rama, M., Ratcliff, B. N., Roudeau, P., Schrenk, S., Schroeder, T., Schubert, K. R., Shen, C. P., Shwartz, B., Soffer, A., Solodov, E. P., Somov, A., Starič, M., Stracka, S., Telnov, A. V., Todyshev, K. Yu., Tsuboyama, T., Uglov, T., Vinokurova, A., Walsh, J. J., Watanabe, Y., Won, E., Wormser, G., Wright, D. H., Ye, S., Zhang, C. C., Abachi, S., Abashian, A., Abe, N., Abe, R., Abe, T., Abrams, G. S., Adam, I., Adamczyk, K., Adametz, A., Adye, T., Agarwal, A., Ahmed, H., Ahmed, M., Ahmed, S., Ahn, B. S., Ahn, H. S., Aitchison, I. J. R., Akai, K., Akar, S., Akatsu, M., Akemoto, M., Akhmetshin, R., Akre, R., Alam, M. S., Albert, J. N., Aleksan, R., Alexander, J. P., Alimonti, G., Allen, M. T., Allison, J., Allmendinger, T., Alsmiller, J. R. G., Altenburg, D., Alwyn, K. E., An, Q., Anderson, J., Andreassen, R., Andreotti, D., Andreotti, M., Andress, J. C., Angelini, C., Anipko, D., Anjomshoaa, A., Anthony, P. L., Antillon, E. A., Antonioli, E., Aoki, K., Arguin, J. F., Arinstein, K., Arisaka, K., Asai, K., Asai, M., Asano, Y., Asgeirsson, D. J., Asner, D. M., Aso, T., Aspinwall, M. L., Aston, D., Atmacan, H., Aubert, B., Aulchenko, V., Ayad, R., Azemoon, T., Aziz, T., Azzolini, V., Azzopardi, D. E., Baak, M. A., Back, J. J., Bagnasco, S., Bahinipati, S., Bailey, D. S., Bailey, S., Bailly, P., van Bakel, N., Bakich, A. M., Bala, A., Balagura, V., Baldini-Ferroli, R., Ban, Y., Banas, E., Band, H. R., Banerjee, S., Baracchini, E., Barate, R., Barberio, E., Barbero, M., Bard, D. J., Barillari, T., Barlow, N. R., Barlow, R. J., Barrett, M., Bartel, W., Bartelt, J., Bartoldus, R., Batignani, G., Battaglia, M., Bauer, J. M., Bay, A., Beaulieu, M., Bechtle, P., Beck, T. W., Becker, J., Becla, J., Bedny, I., Behari, S., Behera, P. K., Behn, E., Behr, L., Beigbeder, C., Beiline, D., Bell, R., Bellini, F., Bellodi, G., Belous, K., Benayoun, M., Benelli, G., Benitez, J. F., Benkebil, M., Berger, N., Bernabeu, J., Bernard, D., Bernet, R., Bernlochner, F. U., Berryhill, J. W., Bertsche, K., Besson, P., Best, D. S., Bettarini, S., Bettoni, D., Bhardwaj, V., Bhimji, W., Bhuyan, B., Biagini, M. E., Biasini, M., van Bibber, K., Biesiada, J., Bingham, I., Bionta, R. M., Bischofberger, M., Bitenc, U., Bizjak, I., Blanc, F., Blaylock, G., Blinov, V. E., Bloom, E., Bloom, P. C., Blount, N. L., Blouw, J., Bly, M., Blyth, S., Boeheim, C. T., Bomben, M., Bondar, A., Bondioli, M., Bonneaud, G. R., Bonvicini, G., Booke, M., Booth, J., Borean, C., Borgland, A. W., Borsato, E., Bosi, F., Bosisio, L., Botov, A. A., Bougher, J., Bouldin, K., Bourgeois, P., Boutigny, D., Bowerman, D. A., Boyarski, A. M., Boyce, R. F., Boyd, J. T., Bozek, A., Bozzi, C., Bračko, M., Brandenburg, G., Brandt, T., Brau, B., Brau, J., Breon, A. B., Breton, D., Brew, C., Briand, H., Bright-Thomas, P. G., Brigljević, V., Britton, D. I., Brochard, F., Broomer, B., Brose, J., Browder, T. E., Brown, C. L., Brown, C. M., Brown, D. N., Browne, M., Bruinsma, M., Brunet, S., Bucci, F., Buchanan, C., Buchmueller, O. L., Bünger, C., Bugg, W., Bukin, A. D., Bula, R., Bulten, H., Burchat, P. R., Burgess, W., Burke, J. P., Button-Shafer, J., Buzykaev, A. R., Buzzo, A., Cai, Y., Calabrese, R., Calcaterra, A., Calderini, G., Camanzi, B., Campagna, E., Campagnari, C., Capra, R., Carassiti, V., Carpinelli, M., Carroll, M., Casarosa, G., Casey, B. C. K., Cason, N. M., Castelli, G., Cavallo, N., Cavoto, G., Cecchi, A., Cenci, R., Cerizza, G., Cervelli, A., Ceseracciu, A., Chai, X., Chaisanguanthum, K. S., Chang, M. C., Chang, Y. H., Chang, Y. W., Chao, D. S., Chao, M., Chao, Y., Charles, E., Chavez, C. A., Cheaib, R., Chekelian, V., Chen, A., Chen, E., Chen, G. P., Chen, H. F., Chen, J. -H., Chen, J. C., Chen, K. F., Chen, P., Chen, S., Chen, W. T., Chen, X., Chen, X. R., Chen, Y. Q., Cheng, B., Cheon, B. G., Chevalier, N., Chia, Y. M., Chidzik, S., Chilikin, K., Chistiakova, M. V., Cizeron, R., Cho, I. S., Cho, K., Chobanova, V., Choi, H. H. F., Choi, K. S., Choi, S. K., Choi, Y., Choi, Y. K., Christ, S., Chu, P. H., Chun, S., Chuvikov, A., Cibinetto, G., Cinabro, D., Clark, A. R., Clark, P. J., Clarke, C. K., Claus, R., Claxton, B., Clifton, Z. C., Cochran, J., Cohen-Tanugi, J., Cohn, H., Colberg, T., Cole, S., Colecchia, F., Condurache, C., Contri, R., Convert, P., Convery, M. R., Cooke, P., Copty, N., Cormack, C. M., Corso, F. Dal, Corwin, L. A., Cossutti, F., Cote, D., Ramusino, A. Cotta, Cottingham, W. N., Couderc, F., Coupal, D. P., Covarelli, R., Cowan, G., Craddock, W. W., Crane, G., Crawley, H. B., Cremaldi, L., Crescente, A., Cristinziani, M., Crnkovic, J., Crosetti, G., Cuhadar-Donszelmann, T., Cunha, A., Curry, S., D'Orazio, A., Dû, S., Dahlinger, G., Dahmes, B., Dallapiccola, C., Danielson, N., Danilov, M., Das, A., Dash, M., Dasu, S., Datta, M., Daudo, F., Dauncey, P. D., David, P., Davis, C. L., Day, C. T., De Mori, F., De Domenico, G., De Groot, N., De la Vaissière, C., de la Vaissière, Ch., de Lesquen, A., De Nardo, G., de Sangro, R., De Silva, A., DeBarger, S., Decker, F. J., Sanchez, P. del Amo, Del Buono, L., Del Gamba, V., del Re, D., Della Ricca, G., Denig, A. G., Derkach, D., Derrington, I. M., DeStaebler, H., Destree, J., Devmal, S., Dey, B., Di Girolamo, B., Di Marco, E., Dickopp, M., Dima, M. O., Dittrich, S., Dittongo, S., Dixon, P., Dneprovsky, L., Dohou, F., Doi, Y., Doležal, Z., Doll, D. A., Donald, M., Dong, L., Dong, L. Y., Dorfan, J., Dorigo, A., Dorsten, M. P., Dowd, R., Dowdell, J., Drásal, Z., Dragic, J., Drummond, B. W., Dubitzky, R. S., Dubois-Felsmann, G. P., Dubrovin, M. S., Duh, Y. C., Duh, Y. T., Dujmic, D., Dungel, W., Dunwoodie, W., Dutta, D., Dvoretskii, A., Dyce, N., Ebert, M., Eckhart, E. A., Ecklund, S., Eckmann, R., Eckstein, P., Edgar, C. L., Edwards, A. J., Egede, U., Eichenbaum, A. M., Elmer, P., Emery, S., Enari, Y., Enomoto, R., Erdos, E., Erickson, R., Ernst, J. A., Erwin, R. J., Escalier, M., Eschenburg, V., Eschrich, I., Esen, S., Esteve, L., Evangelisti, F., Everton, C. W., Eyges, V., Fabby, C., Fabozzi, F., Fahey, S., Falbo, M., Fan, S., Fang, F., Fanin, C., Farbin, A., Farhat, H., Fast, J. E., Feindt, M., Fella, A., Feltresi, E., Ferber, T., Fernholz, R. E., Ferrag, S., Ferrarotto, F., Ferroni, F., Field, R. C., Filippi, A., Finocchiaro, G., Fioravanti, E., da Costa, J. Firmino, Fischer, P. -A., Fisher, A., Fisher, P. H., Flacco, C. J., Flack, R. L., Flaecher, H. U., Flanagan, J., Flanigan, J. M., Ford, K. E., Ford, W. T., Forster, I. J., Forti, A. C., Forti, F., Fortin, D., Foster, B., Foulkes, S. D., Fouque, G., Fox, J., Franchini, P., Sevilla, M. Franco, Franek, B., Frank, E. D., Fransham, K. B., Fratina, S., Fratini, K., Frey, A., Frey, R., Friedl, M., Fritsch, M., Fry, J. R., Fujii, H., Fujikawa, M., Fujita, Y., Fujiyama, Y., Fukunaga, C., Fukushima, M., Fullwood, J., Funahashi, Y., Funakoshi, Y., Furano, F., Furman, M., Furukawa, K., Futterschneider, H., Gabathuler, E., Gabriel, T. A., Gabyshev, N., Gaede, F., Gagliardi, N., Gaidot, A., Gaillard, J. -M., Gaillard, J. R., Galagedera, S., Galeazzi, F., Gallo, F., Gamba, D., Gamet, R., Gan, K. K., Gandini, P., Ganguly, S., Ganzhur, S. F., Gao, Y. Y., Gaponenko, I., Garmash, A., Tico, J. Garra, Garzia, I., Gaspero, M., Gastaldi, F., Gatto, C., Gaur, V., Geddes, N. I., Geld, T. L., Genat, J. -F., George, K. A., George, M., George, S., Georgette, Z., Gershon, T. J., Gill, M. S., Gillard, R., Gilman, J. D., Giordano, F., Giorgi, M. A., Giraud, P. -F., Gladney, L., Glanzman, T., Glattauer, R., Go, A., Goetzen, K., Goh, Y. M., Gokhroo, G., Goldenzweig, P., Golubev, V. B., Gopal, G. P., Gordon, A., Gorišek, A., Goriletsky, V. I., Gorodeisky, R., Gosset, L., Gotow, K., Gowdy, S. J., Graffin, P., Grancagnolo, S., Grauges, E., Graziani, G., Green, M. G., Greene, M. G., Grenier, G. J., Grenier, P., Griessinger, K., Grillo, A. A., Grinyov, B. V., Gritsan, A. V., Grosdidier, G., Perdekamp, M. Grosse, Grosso, P., Grothe, M., Groysman, Y., Grünberg, O., Guido, E., Guler, H., Gunawardane, N. J. W., Guo, Q. H., Guo, R. S., Guo, Z. J., Guttman, N., Ha, H., Ha, H. C., Haas, T., Haba, J., Hachtel, J., Hadavand, H. K., Hadig, T., Hagner, C., Haire, M., Haitani, F., Haji, T., Haller, G., Halyo, V., Hamano, K., Hamasaki, H., de Monchenault, G. Hamel, Hamilton, J., Hamilton, R., Hamon, O., Han, B. Y., Han, Y. L., Hanada, H., Hanagaki, K., Handa, F., Hanson, J. E., Hanushevsky, A., Hara, K., Hara, T., Harada, Y., Harrison, P. F., Harrison, T. J., Harrop, B., Hart, A. J., Hart, P. A., Hartfiel, B. L., Harton, J. L., Haruyama, T., Hasan, A., Hasegawa, Y., Hast, C., Hastings, N. C., Hasuko, K., Hauke, A., Hawkes, C. M., Hayashi, K., Hazumi, M., Hee, C., Heenan, E. 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E., Walker, D., Walkowiak, W., Wallom, D., Wang, C. C., Wang, C. H., Wang, J., Wang, J. G., Wang, K., Wang, L., Wang, L. L., Wang, P., Wang, T. J., Wang, W. F., Wang, X. L., Wang, Y. F., Wappler, F. R., Watanabe, M., Watson, A. T., Watson, J. E., Watson, N. K., Watt, M., Weatherall, J. H., Weaver, M., Weber, T., Wedd, R., Wei, J. T., Weidemann, A. W., Weinstein, A. J. R., Wenzel, W. A., West, C. A., West, C. G., West, T. J., White, E., White, R. M., Wicht, J., Widhalm, L., Wiechczynski, J., Wienands, U., Wilden, L., Wilder, M., Williams, D. C., Williams, G., Williams, J. C., Williams, K. M., Williams, M. I., Willocq, S. Y., Wilson, J. R., Wilson, M. G., Wilson, R. J., Winklmeier, F., Winstrom, L. O., Winter, M. A., Wisniewski, W. J., Wittgen, M., Wittlin, J., Wittmer, W., Wixted, R., Woch, A., Wogsland, B. J., Wong, Q. K., Wray, B. C., Wren, A. C., Wright, D. M., Wu, C. H., Wu, J., Wu, S. L., Wulsin, H. W., Xella, S. M., Xie, Q. L., Xie, Y., Xu, Z. Z., Yèche, Ch., Yamada, Y., Yamaga, M., Yamaguchi, A., Yamaguchi, H., Yamaki, T., Yamamoto, H., Yamamoto, N., Yamamoto, R. K., Yamamoto, S., Yamanaka, T., Yamaoka, H., Yamaoka, J., Yamaoka, Y., Yamashita, Y., Yamauchi, M., Yan, D. S., Yan, Y., Yanai, H., Yanaka, S., Yang, H., Yang, R., Yang, S., Yarritu, A. K., Yashchenko, S., Yashima, J., Yasin, Z., Yasu, Y., Ye, S. W., Yeh, P., Yi, J. I., Yi, K., Yi, M., Yin, Z. W., Ying, J., Yocky, G., Yokoyama, K., Yokoyama, M., Yokoyama, T., Yoshida, K., Yoshida, M., Yoshimura, Y., Young, C. C., Yu, C. X., Yu, Z., Yuan, C. Z., Yuan, Y., Yumiceva, F. X., Yusa, Y., Yushkov, A. N., Yuta, H., Zacek, V., Zain, S. B., Zallo, A., Zambito, S., Zander, D., Zang, S. L., Zanin, D., Zaslavsky, B. G., Zeng, Q. L., Zghiche, A., Zhang, B., Zhang, J., Zhang, L., Zhang, L. M., Zhang, S. Q., Zhang, Z. P., Zhao, H. W., Zhao, M., Zhao, Z. G., Zheng, Y., Zheng, Y. H., Zheng, Z. P., Zhilich, V., Zhou, P., Zhu, R. Y., Zhu, Y. S., Zhu, Z. M., Zhulanov, V., Ziegler, T., Ziegler, V., Zioulas, G., Zisman, M., Zito, M., Zürcher, D., Zwahlen, N., Zyukova, O., Živko, T., and Žontar, D.
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High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
This work is on the Physics of the B Factories. Part A of this book contains a brief description of the SLAC and KEK B Factories as well as their detectors, BaBar and Belle, and data taking related issues. Part B discusses tools and methods used by the experiments in order to obtain results. The results themselves can be found in Part C. Please note that version 3 on the archive is the auxiliary version of the Physics of the B Factories book. This uses the notation alpha, beta, gamma for the angles of the Unitarity Triangle. The nominal version uses the notation phi_1, phi_2 and phi_3. Please cite this work as Eur. Phys. J. C74 (2014) 3026., Comment: 928 pages, version 3 (arXiv:1406.6311v3) corresponds to the alpha, beta, gamma version of the book, the other versions use the phi1, phi2, phi3 notation
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- 2014
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17. First record of the exotic species Axis axis (Erxleben, 1777) (Artiodactyla, Cervidae) in the state of Santa Catarina, southern Brazil
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Jackson F. Preuss, Eduarda Posser, Laura B. Albrecht, Victor P.R. da Silva, and Fernanda C. Bandiera
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Deer ,conservation ,invasion ,natural environments ,Biology (General) ,QH301-705.5 - Abstract
In this work, we describe the first occurrence record of the exotic species of deer Axis axis (Erxleben, 1777) from natural environments of the state of Santa Catarina, southern Brazil. The study provides information about the implications of the invasion of the region’s ecosystem, which is seen as a negative factor in the local community and represents a major conservation challenge.
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- 2020
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18. Predicting Outcomes for Interhospital Transferred Patients of Emergency General Surgery
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Brandon Cave, Daniel Najafali, William Gilliam, Jackson F. Barr, Christian Cain, Chris Yum, Jamie Palmer, Safura Tanveer, Emily Esposito, and Quincy K. Tran
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Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Background. Interhospital transferred (IHT) emergency general surgery (EGS) patients are associated with high care intensity and mortality. However, prior studies do not focus on patient-level data. Our study, using each IHT patient’s data, aimed to understand the underlying cause for IHT EGS patients’ outcomes. We hypothesized that transfer origin of EGS patients impacts outcomes due to critical illness as indicated by higher Sequential Organ Failure Assessment (SOFA) score and disease severity. Materials and Methods. We conducted a retrospective analysis of all adult patients transferred to our quaternary academic center’s EGS service from 01/2014 to 12/2016. Only patients transferred to our hospital with EGS service as the primary service were eligible. We used multivariable logistic regression and probit analysis to measure the association of patients’ clinical factors and their outcomes (mortality and survivors’ hospital length of stay [HLOS]). Results. We analyzed 708 patients, 280 (39%) from an ICU, 175 (25%) from an ED, and 253 (36%) from a surgical ward. Compared to ED patients, patients transferred from the ICU had higher mean (SD) SOFA score (5.7 (4.5) vs. 2.39 (2), P
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- 2022
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19. First record of the exotic species Axis axis (Erxleben, 1777) (Artiodactyla, Cervidae) in the state of Santa Catarina, southern Brazil
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Preuss, Jackson F., Posser, Eduarda, Albrecht, Laura B., da Silva, Victor P. R., and Bandiera, Fernanda C.
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- 2020
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20. Ultra-Luminous X-Ray Sources in the Most Metal Poor Galaxies
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Prestwich, A. H., Tsantaki, M., Zezas, A., Jackson, F. E., Roberts, T. P., Foltz, R., Linden, T., and Kalogera, V.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Ultra-Luminous X-ray sources (ULX) are X-ray binaries with Lx>1E^39 ergs/s. The most spectacular examples of ULX occur in starburst galaxies and are now understood to be young, luminous High Mass X-ray Binaries. The conditions under which ULX form are poorly understood, but recent evidence suggests they may be more common in low metallicity systems. Here we investigate the hypothesis that ULX form preferentially in low metallicity galaxies by searching for ULX in a sample of Extremely Metal Poor Galaxies (XMPG) observed with the Chandra X-ray Observatory. XMPG are defined as galaxies with log(O/H)+12<7.65, or less than 5% solar. These are the most metal-deficient galaxies known, and a logical place to find ULX if they favor metal poor systems. We compare the number of ULX (corrected for background contamination) per unit of star formation (Nulx) in the XMPG sample with Nulx in a comparison sample of galaxies with higher metallicities taken from the Spitzer Infrared Galaxy Sample (SINGS). We find that ULX occur preferentially in the metal poor sample with a formal statistical significance of 2.3 sigma. We do not see strong evidence for a trend in the formation of ULX in the high metallicity sample: above 12+log(O/H) ~ 8.0 the efficiency of ULX production appears to be flat. The effect we see is strongest in the lowest metallicity bin. We discuss briefly the implications of these results for the formation of black holes in low metallicity gas., Comment: Accepted for publication in ApJ
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- 2013
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21. Zoonotic bacteria research and analysis of antimicrobial resistance levels in parrot isolates from pet shops in the city of Fortaleza, Brazil
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Adson R. Marques, Bruno P. Lima, Régis S.C. Teixeira, Átilla H. Albuquerque, Elisângela S. Lopes, William C. Maciel, Antonio Jackson F. Beleza, and Thiago R. Alencar
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Zoonotic bacteria ,antimicrobial resistance ,parrot ,pet shops ,Brazil ,birds ,bacteria ,antibiotic resistance ,wildlife animals ,Veterinary medicine ,SF600-1100 - Abstract
ABSTRACT: The Psittaciformes are among the most popular pets due to their intelligence, ability, and ease of maintenance in small environments. However, the absence of adequate environmental stimuli generated by confinement can predispose these animals to characteristic stress conditions, leaving them susceptible to the triggering of various diseases, among which those of bacterial origin stand out. The objective of this study was to carry out a survey of enterobacteria and evaluate the antimicrobial sensitivity profile of bacteria isolated from parrots from a pet shop in the city of Fortaleza, Ceará. Ninety-six samples were collected from four pet shops (which were classified as A, B, C and D), eight samples of local swabs from budgerigar (Melopsittacus undulatus), were collected from each establishment eight from cockatiels (Nymphicus hollandicus) and eight from lovebirds (Agapornis sp.). Isolation of enterobacteria is under the methodology used by Lopes et al. (2015) with modifications. The method used to study bacterial resistance was the Kirby-Bauer method, following the standards stipulated by the Clinical and Laboratory Standards Institute. Sixty-eight enterobacteria strains from ten different species, Proteus mirabilis, Citrobacter diversus, Pantoea agglomerans, Escherichia coli, Providencia stuartii, Hafnia alvei, Proteus vulgaris, Serratia liquefaciens, Enterobacter sakasakii and Citrobacter amalonaticus, were isolated. P. agglomerans was the bacterium with the highest frequency of isolates from pet shop parrots, making up 23.5% of the isolates; the second-most isolated strain was P. mirabilis with 17.7%. In this study, 79% of the isolated strains were resistant to at least one class of antimicrobials tested. Tetracycline proved to be the most resistant antimicrobial (44%), followed by polymyxin B (38%) and nalidixic acid (25%). Among the 68 strains, 19% did not show resistance to any of the classes of antimicrobials tested. The condition of multidrug resistance - resistance to ≥3 classes of antimicrobials - was observed in 18% of the isolated strains.
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- 2021
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22. Antimicrobial susceptibility profile of enterobacteria isolated from wild grey-breasted parakeets (Pyrrhura griseipectus)
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Antonio Jackson F. Beleza, William Cardoso Maciel, Arianne S. Carreira, Adson R. Marques, Fabio P. Nunes, Tânia F. Raso, Ruben H. Vasconcelos, and Régis S.C. Teixeira
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Enterobacteria ,wild grey-breasted parakeets ,Pyrrhura griseipectus ,antimicrobial resistance ,conservation ,psittacine birds ,threatened species ,wildlife animals ,Veterinary medicine ,SF600-1100 - Abstract
ABSTRACT: The grey-breasted parakeet (Pyrrhura griseipectus) is an endangered psittacine species that have been affected by illegal trade and deforestation. Currently, this endemic species is only found in three areas in Ceará state, in Brazil. This study aimed to investigate the frequency and diversity of Enterobacteriaceae in wild adult grey-breasted parakeets and determine their susceptibility to antimicrobial agents. Cloacal swab samples were collected from 27 individuals and environmental swabs (drag swabs) from five nests used by these birds. Twenty-seven strains from nine species of Enterobacteriaceae were recovered from cloacal swabs, and the most prevalent bacteria strains were Hafnia alvei (22%) and Pantoea agglomerans (22%). From environmental nest samples, seven strains from three bacterial species were isolated, being the P. agglomerans the most frequent species (100%). Twenty-two of the 27 isolates (81.4%) exhibited antibiotic resistance, varying from one to eight of the 12 antimicrobials commonly used. Resistance to amoxicillin was the most prevalent (70.4%), followed by azithromycin (22.2%) and ceftriaxone (18.5%). None of the strains were resistant to gentamicin, tobramycin, ciprofloxacin or tetracycline. The H. alvei was the main species presenting multidrug resistance, including resistance against meropenem, which is an important finding. These results could provide interesting information on the health of these endangered wild grey-breasted parakeets. They could also indicate that the obtained isolates are part of a group of bacteria that are typical components of the enteric microbiota of birds, which present elevated rates of resistance to amoxicillin.
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- 2021
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23. On the nature of high X-ray luminosities in SDSS galaxies
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Jackson, F. E., Roberts, T. P., Alexander, D. M., Gelbord, J. M., Goulding, A. D., Ward, M. J., Wardlow, J. L., and Watson, M. G.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Surveys have revealed a class of object displaying both high X-ray luminosities (Lx > 10^42 erg/s), and a lack of a discernible active galactic nucleus (AGN) in the optical band. If these sources are powered by star formation activity alone, they would be the most extreme X-ray luminosity star forming galaxies known. We have investigated the mechanism driving the X-ray luminosities of such galaxies by studying the X-ray emission of three moderate redshift (z ~ 0.1) examples of this class, selected from a cross-correlation of the SDSS-DR5 and 2XMMp-DR0 catalogues. X-ray spatial and long-term variability diagnostics of these sources suggest that they are compact X-ray emitters. This result is supported by the detection of rapid short term variability in an observation of one of the sources. The X-ray spectra of all three sources are best fitted with a simple absorbed power-law model, thus betraying no significant signs of star formation. These results indicate that the X-ray emission is powered by AGN activity. But why do these sources not display optical AGN signatures? We show that the most likely explanation is that the optical AGN emission lines are being diluted by star formation signatures from within their host galaxies., Comment: 13 pages, 6 figures, MNRAS in press
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- 2012
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24. Status report of the baseline collimation system of CLIC. Part I
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Resta-Lopez, J., Angal-Kalinin, D., Dalena, B., Fernandez-Hernando, J. L., Jackson, F., Schulte, D., Seryi, A., and Tomas, R.
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Physics - Accelerator Physics - Abstract
Important efforts have recently been dedicated to the characterisation and improvement of the design of the post-linac collimation system of the Compact Linear Collider (CLIC). This system consists of two sections: one dedicated to the collimation of off-energy particles and another one for betatron collimation. The energy collimation system is further conceived as protection system against damage by errant beams. In this respect, special attention is paid to the optimisation of the energy collimator design. The material and the physical parameters of the energy collimators are selected to withstand the impact of an entire bunch train. Concerning the betatron collimation section, different aspects of the design have been optimised: the transverse collimation depths have been recalculated in order to reduce the collimator wakefield effects while maintaining a good efficiency in cleaning the undesired beam halo; the geometric design of the spoilers has been reviewed to minimise wakefields; in addition, the optics design has been optimised to improve the collimation efficiency. This report presents the current status of the the post-linac collimation system of CLIC. Part I of this report is dedicated to the study of the CLIC energy collimation system., Comment: 22 pages, 14 figures
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- 2011
25. Results from a Prototype Chicane-Based Energy Spectrometer for a Linear Collider
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Lyapin, A., Schreiber, H. J., Viti, M., Adolphsen, C., Arnold, R., Boogert, S., Boorman, G., Chistiakova, M. V., Gournaris, F., Duginov, V., Hast, C., Hildreth, M. D., Hlaing, C., Jackson, F., Khainovsky, O., Kolomensky, Yu. G., Kostromin, S., Kumar, K., Maiheu, B., McCormick, D., Miller, D. J., Morozov, N., Orimoto, T., Petigura, E., Sadre-Bazzaz, M., Slater, M., Szalata, Z., Thomson, M., Ward, D., Wendt, M., Wing, M., and Woods, M.
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Physics - Accelerator Physics ,High Energy Physics - Experiment - Abstract
The International Linear Collider and other proposed high energy e+ e- machines aim to measure with unprecedented precision Standard Model quantities and new, not yet discovered phenomena. One of the main requirements for achieving this goal is a measurement of the incident beam energy with an uncertainty close to 1e-4. This article presents the analysis of data from a prototype energy spectrometer commissioned in 2006--2007 in SLAC's End Station A beamline. The prototype was a 4-magnet chicane equipped with beam position monitors measuring small changes of the beam orbit through the chicane at different beam energies. A single bunch energy resolution close to 5e-4 was measured, which is satisfactory for most scenarios. We also report on the operational experience with the chicane-based spectrometer and suggest ways of improving its performance., Comment: To be submitted to Journal of Instrumentation
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- 2010
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26. Challenging times: a re-analysis of NGC 5408 X-1
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Middleton, M. J., Roberts, T. P., Done, C., and Jackson, F. E.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The ultraluminous X-ray source (ULX), NGC 5408 X-1, is one of only 3 such objects to show a quasi-periodic oscillation (QPO) in its power spectrum. Previous analysis of this signal identified it with the well-studied type C low-frequency QPO (LFQPO) seen in black hole binaries (BHBs), implying an intermediate mass black hole (IMBH). However, in BHBs this QPO has a centroid frequency which scales tightly with the position of the low-frequency break in the broad band power spectrum. We use this relation to predict the frequency of the power spectral break in NGC 5408 X-1, and show that this is inconsistent with the break frequencies in both available, archival XMM-Newton observations. Thus the broad band power spectral shape does not support this identification of the QPO. The energy spectra also do not support an IMBH interpretation. They can be fit by a two-component model, best described by soft thermal emission at low energies, together with low-temperature, optically thick Comptonisation producing a tail which dominates above 2 keV. The parameters of the tail are unlike those seen in any of the sub-Eddington BHB spectral states. The energy dependent variability supports this deconvolution, as it is consistent with the soft thermal component below 2 keV diluting extreme variability of the high energy tail. The only objects with similar spectra which have similar amounts of variability are the BHB, GRS 1915+105, and some extreme NLS1s. This suggests that NGC 5408 X-1 is in a similar super-Eddington state, placing a natural limit on the mass of < 100 solar masses. Its QPO could then be similar to the ultra-LFQPO seen occasionally in GRS 1915+105, consistent with a large stellar mass black hole. We suggest a model geometry which may explain the spectra and variability of highly super-Eddington sources., Comment: 10 pages, 8 figures, accepted by MNRAS
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- 2010
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27. Modelling dynamic pantograph loads with combined numerical analysis
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Jackson, F. F., primary, Mishra, R., additional, Rebelo, J. M., additional, Santos, J., additional, Antunes, P., additional, Pombo, J., additional, Magalhães, H., additional, Wills, L., additional, and Askill, M., additional
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- 2023
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28. Drought impacts on river water temperature: A process‐based understanding from temperate climates
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White, J. C., primary, Khamis, K., additional, Dugdale, S., additional, Jackson, F. L., additional, Malcolm, I. A., additional, Krause, S., additional, and Hannah, D. M., additional
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- 2023
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29. Management of Ocular Adnexal Trauma
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Lever, Jackson F., primary, Barmettler, Anne, additional, and Levine, Mark R., additional
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- 2020
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30. Cavity BPM System Tests for the ILC Spectrometer
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Slater, M., Adolphsen, C., Arnold, R., Boogert, S., Boorman, G., Gournaris, F., Hildreth, M., Hlaing, C., Jackson, F., Khainovski, O., Kolomensky, Yu. G., Lyapin, A., Maiheu, B., McCormick, D., Miller, D. J., Orimoto, T. J., Szalata, Z., Thomson, M., Ward, D., Wing, M., and Woods, M.
- Subjects
Physics - Instrumentation and Detectors - Abstract
The main physics programme of the International Linear Collider (ILC) requires a measurement of the beam energy at the interaction point with an accuracy of $10^{-4}$ or better. To achieve this goal a magnetic spectrometer using high resolution beam position monitors (BPMs) has been proposed. This paper reports on the cavity BPM system that was deployed to test this proposal. We demonstrate sub-micron resolution and micron level stability over 20 hours for a $1\m$ long BPM triplet. We find micron-level stability over 1 hour for 3 BPM stations distributed over a $30\m$ long baseline. The understanding of the behaviour and response of the BPMs gained from this work has allowed full spectrometer tests to be carried out., Comment: Paper submitted to Nuclear Instruments and Methods. 35 pages, 23 figures
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- 2007
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31. A dual role of microbiota type 17 immunity in tissue repair and pain
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Paul J Austin, Jackson F Karrasch, and Jayden A O'Brien
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Immunology ,Immunology and Allergy ,Cell Biology - Published
- 2023
32. Design of an interaction region with head-on collisions for the ILC
- Author
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Appleby, R., Angal-Kalinin, D., Jackson, F., Alabau-Pons, M ., Bambade, P., Brossard, J., Dadoun, O., Rimbault, C., Keller, L., Nosochkov, Y., Seryi, A., Payet, J., Napoly, O., Rippon, C., and Uriot, D.
- Subjects
Physics - Accelerator Physics - Abstract
An interaction region (IR) with head-on collisions is considered as an alternative to the baseline configuration of the International Linear Collider (ILC) which includes two IRs with finite crossing-angles (2 and 20 mrad). Although more challenging for the beam extraction, the head-on scheme is favoured by the experiments because it allows a more convenient detector configuration, particularly in the forward region. The optics of the head-on extraction is revisited by separating the e+ and e- beams horizontally, first by electrostatic separators operated at their LEP nominal field and then using a defocusing quadrupole of the final focus beam line. In this way the septum magnet is protected from the beamstrahlung power. Newly optimized final focus and extraction optics are presented, including a first look at post-collision diagnostics. The influence of parasitic collisions is shown to lead to a region of stable collision parameters. Disrupted beam and beamstrahlung photon losses are calculated along the extraction elements.
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- 2006
33. A Test Facility for the International Linear Collider at SLAC End Station A, for Prototypes of Beam Delivery and IR Components
- Author
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Woods, M., Erickson, R., Frisch, J., Hast, C., Jobe, R. K., Keller, L., Markiewicz, T., Maruyama, T., McCormick, D., Nelson, J., Nelson, T., Phinney, N., Raubenheimer, T., Ross, M., Seryi, A., Smith, S., Szalata, Z., Tenenbaum, P., Woodley, M., Angal-Kalinin, D., Beard, C., Densham, C., Greenhalgh, J., Jackson, F., Kalinin, A., Zimmermann, F., Zagorodnov, I., Sugimoto, Y., Walston, S., Burton, D., Smith, J., Shales, N., Sopczak, A., Tucker, R., Barlow, R., Kurevlev, G., Mercer, A., Hildreth, M., Burrows, P., Christian, G., Clarke, C., Hartin, A., Molloy, S., White, G., Mueller, W., Weiland, T., Watson, N., Bailey, D., Cussans, D., Kolomensky, Y., Slater, M., Thomson, M., Ward, D., Boogert, S., Liapine, A., Malton, S., Miller, D. J., Wing, M., Arnold, R., Sinev, N., and Torrence, E.
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Physics - Instrumentation and Detectors - Abstract
The SLAC Linac can deliver damped bunches with ILC parameters for bunch charge and bunch length to End Station A. A 10Hz beam at 28.5 GeV energy can be delivered there, parasitic with PEP-II operation. We plan to use this facility to test prototype components of the Beam Delivery System and Interaction Region. We discuss our plans for this ILC Test Facility and preparations for carrying out experiments related to collimator wakefields and energy spectrometers. We also plan an interaction region mockup to investigate effects from backgrounds and beam-induced electromagnetic interference., Comment: 3 pages, 3 figures, contributed to Particle Accelerator Conference (PAC05), Knoxville, TN, May 16-20, 2005
- Published
- 2005
34. Beekeeping and Managed Bee Diversity in Indonesia: Perspective and Preference of Beekeepers
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Damayanti Buchori, Akhmad Rizali, Windra Priawandiputra, Rika Raffiudin, Dewi Sartiami, Yulia Pujiastuti, Jauharlina, Mahardika Gama Pradana, Araz Meilin, Johanna Audrey Leatemia, I Putu Sudiarta, Rusli Rustam, Novri Nelly, Puji Lestari, Edy Syahputra, Hasriyanti, Jackson F. Watung, Itji Diana Amin Daud, Nova Hariani, Amrul Jihadi, and Midzon Johannis
- Subjects
honey bees ,stingless bees ,traditional beekeeping ,pests ,climate change ,Biology (General) ,QH301-705.5 - Abstract
There is a high diversity of bees in the tropics, including honey bees and stingless bees, which are the main sources for honey and other ecosystem services. In Indonesia, beekeeping practices have been developed for centuries, and they have been part of many cultural practices in many traditional communities. The objective of this research was to study the beekeeping status and managed bee diversity in Indonesia and to investigate beekeepers’ perspectives on the factors and obstacles related to beekeeping. Direct interview and online interview were conducted to gain data on bees and beekeepers. In total, 272 beekeepers were interviewed across 25 provinces. Samplings of honey bees and stingless bees were also done during direct interviews for further identification and, when possible, pollen identification. All data and specimens were then sent to IPB Bogor for compilation and identification. We recorded 22 species of bees, including 3 species of honey bees and 19 species of stingless bees, that are reared by Indonesian beekeepers, with Apis cerana and Tetragonula laeviceps as the most common species. Our research also found that the majority of beekeepers fall into the category of the younger generation (30–39 years old) with educational background mostly from senior high school. Based on the beekeepers’ perspectives, there are several obstacles to beekeeping, especially the occurrence of death of bee foragers attributed to climate, food source, and pesticides. In conclusion, there is a need to develop a strategy for beekeeping and bee conservation in Indonesia, especially for adaptation and mitigation from environmental changes with a particular focus on climate and land-use change.
- Published
- 2022
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35. Extension of the Drosophila Lifespan by Overexpression of a Protein Repair Methyltransferase
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Chavous, David A., Jackson, F. Rob, and O'Connor, Clare M.
- Published
- 2001
36. Agrioglypta ubaidillahi Watung & Darmawan & Suwito & Narakusumo & Nugroho & Encilia & Qodri & Peggie & Ubaidillah & Sutrisno 2023, sp. nov
- Author
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Watung, Jackson F., Darmawan, Darmawan, Suwito, Awit, Narakusumo, Raden Pramesa, Nugroho, Hari, Encilia, Encilia, Qodri, Agmal, Peggie, Djunijanti, Ubaidillah, Rosichon, and Sutrisno, Hari
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Lepidoptera ,Insecta ,Arthropoda ,Agrioglypta ubaidillahi ,Animalia ,Crambidae ,Agrioglypta ,Biodiversity ,Taxonomy - Abstract
Agrioglypta ubaidillahi Sutrisno, sp. nov. Figs 2A–C, G–I Diagnosis. Agrioglypta ubaidillahi sp. nov. is easily distinguished from the closest species, A. naralis, by a brown trapezoidal medial band on the forewing which runs from costa to dorsum, followed by a yellowish U-shaped, wider and white band and white fringe at the middle of the termen (Fig. 2A). The brown trapezoidal medial band of the forewing of A. naralis is narrower. Moreover, the yellowish U-shaped band of A. naralis is more or less equilateral and the termen with yellow fringe at middle (Fig. 2D). In addition, the base of fibula of male genitalia of this new species arise from the mid of costa and the juxta strongly sclerotized. On the other hand the base of fibula of A. naralis arise from the mid of valva and the juxta less sclerotized (Figs 2B–C, E–F). Description. Male (Fig. 2A): Forewing length 10 mm. Head with frons with black scales at middle and yellowish-white at edge and vertex black. Labial palpus white at base, black at middle, and yellowish-white at tip. Maxillary palpus prominent, black except at third segment yellowish-white. Proboscis white. Antennae filiform, extending to approximately full forewing length, dorsal surface with longitudinal row of black scales, and ventral surface with minute yellow cilia. Thorax black dorsally, white ventrally, patagia black with white scales at middle and tegulae white. Legs yellowish-white except for foretibia and epiphysis covered with black scales. Forewing triangular, yellowish-white terminal cilia with black scales at apex and tornus. Hindwing with a yellow thin discal bar and yellowish-white fringe running from Sc+R 1 towards CuA 1. Abdomen slender, first segment toward 8 th black gradually fading to dark brown, ventral 9 th segment has dense black tuft scales, curved upwards to cover anal lobe. Male genitalia (Figs 2B, C). Tegumen subtriangular, subscaphium weakly sclerotized, uncus curved dorsoventrally, medially narrow and distally blunt extending just beyond apical valva. Valva leaf-shaped, costa slightly sinuate, ventrally with scattered distal piliform scales. Fibula curved inwards, sharply pointed apically. Coremata moderate, almost as large as valva, with weak, lamellar scales. Vinculum simple, keel-shaped. Phallus long and thin, approximately three times length of abdomen. Female (Fig. 2G): Similar to male, except for yellow scales of 9 th segment which cover anal lobe. Female genitalia (Figs 2H, I): Anal lobe ovate, with faint scattered piliform scales; anterior long, almost equal to posterior apophyses; entrance to ostium bursae wide, very membranous; antrum short, less than length of anterior apophyses, weakly sclerotized; ductus bursae very thin and long (more than 20 times of corpus bursae); corpus bursae globular with a pair rounded signa with denticules. Holotype: ♁; SE Sulawesi, Kolaka, Wawo, Tinukan, Mt. Mekongga. S 03° 38 ʹ 17 ʺ E 121° 11 ʹ 35.2 ʺ. Alt. 1449 m. 02.VII.2011. Ubaidillah R, B. Kimsey, Nugroho H, Darmawan, Pungki L, Giyanto. MZB Lepi. 664; MZB. Paratypes: 1 ♀; SE Sulawesi, Kolaka, Wawo, Tinukan, Mt. Mekongga. S 03° 37 ʹ 55 ʺ E; 121° 13 ʹ 15.2 ʺ. Alt. 1880 m. 04.VII. 2011. Ubaidillah R, Kimsey L, Nugroho H, Darmawan, Pungki L, Giyanto. MZB. Lepi. 254 (MZB); 1 ♁; SE Sulawesi, Kolaka, Wawo, Tinukan, Mt. Mekongga. S 03° 37 ʹ 55 ʺ E 121° 13 ʹ 55.2 ʺ. Alt. 1880 m. 05. VII. 2011. Ubaidillah R, Kimsey, L, Nugroho H, Darmawan, Pungki L, Giyanto MZB. Lepi. 249 (MZB); 2 ♁; Indonesia, Sulawesi Tengah, Lore Lindu N.P., Rano Rano, 1600 m, 10km NE Gimpu, 13.iii.1985 & 14.iii.1985, J.P. & M.J. Duffels, Stat. 40, Lower montane forest, MV-light, RMNH.INS.1453666 & RMNH.INS.1453667 (RMNH). Etymology. The specific name ubaidillahi is dedicated to Rosichon Ubaidillah for his dedication in leading the expedition to Sulawesi that resulted this new species. A noun in the genitive case. Distribution. Mountain Mekongga, Southeast Sulawesi and Central Sulawesi (Fig. 4). Remark: Adults were collected using a light trap at altitude> 1449 m. above sea level., Published as part of Watung, Jackson F., Darmawan, Darmawan, Suwito, Awit, Narakusumo, Raden Pramesa, Nugroho, Hari, Encilia, Encilia, Qodri, Agmal, Peggie, Djunijanti, Ubaidillah, Rosichon & Sutrisno, Hari, 2023, The genus Agrioglypta Meyrick (Lepidoptera: Crambidae, Spilomelinae) from Indonesia with descriptions of three new species, pp. 569-578 in Zootaxa 5297 (4) on page 573, DOI: 10.11646/zootaxa.5297.4.6, http://zenodo.org/record/8009245
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37. Agrioglypta halimunensis Watung & Darmawan & Suwito & Narakusumo & Nugroho & Encilia & Qodri & Peggie & Ubaidillah & Sutrisno 2023, sp. nov
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Watung, Jackson F., Darmawan, Darmawan, Suwito, Awit, Narakusumo, Raden Pramesa, Nugroho, Hari, Encilia, Encilia, Qodri, Agmal, Peggie, Djunijanti, Ubaidillah, Rosichon, and Sutrisno, Hari
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Lepidoptera ,Insecta ,Arthropoda ,Animalia ,Crambidae ,Agrioglypta ,Biodiversity ,Agrioglypta halimunensis ,Taxonomy - Abstract
Agrioglypta halimunensis Sutrisno, sp. nov. Figs 3A–C, G–I Diagnosis. Agrioglypta halimunensis sp. nov. is easily distinguished from A. jaculalis (Snellen 1894) by a post medial line with three alternate bands: yellowish white, gray, and dark brown scales and the margin with yellowish white scales at middle. Moreover, the hindwing of this new species with a dark brown scales at middle area between M 3 and CuA 1 (Fig. 3A). The male genitalia of this new species with dense and piliform scales at ventral part of a simple valve, and the uncus never extended beyond the valva. On the other hand, the valva of A. jaculalis with a strong frame a costa and the uncus always extended beyond the valva (Figs 3B–C, E–F). Description. Male (Fig. 3A). Forewing length 7 mm. Head with frons partly with black scales at middle and yellowish-white at edge and vertex black at middle and white-yellowish at edge. Labial palpus white at base, black at middle, and white-yellowish at tip. Maxillary palpus prominent, black except at third segment white-yellowish. Proboscis white.Antennae filiform extending approximately full forewing length, dorsal surface covered a longitudinal row of black scales, and ventral surface with minute yellow cilia. Thorax black dorsally, white-ochreous ventrally, patagia black with white scales at middle. Tegulae black at middle and white at edge. Legs white-ochreous. Forewing triangular with yellow termen, surrounded by black scales, and terminal cilia ochreous. Hindwing with a prominent, yellowish-brown sickle-shaped of discal bar and a yellowish-white fringe running from Sc+R 1 towards CuA 2. Abdomen slender, first segment towards 8 th white ochreous with black to dark brown tinged scales, ventrally 9 th segment with dense grey scales, curved upwards cover anal lobe. Male genitalia (Figs 3B–C). Tegumen subtriangular, subscaphium weakly sclerotized, uncus curved dorsoventrally, apically blunt, reaching at half of valva. Valva simple, leaf-shaped, with dense long piliform scales ventrally, fibula curves inwards, with a sharp apex. Coremata large with a weak bundle of lamellar scales, easily detached during slide mounting. Vinculum simple, keel-shaped. Phallus long (more than ten times of length of valva) and thin. Female (Fig. 3G). Similar to male, except for ventral yellow scales of 9 th segment which cover anal lobe. Female genitalia (Figs 3H–I). Anal lobe ovate with faint piliform scales, posterior apophyses short, half length of anterior apophyses. Ostium bursae moderately wide; antrum weakly sclerotized, short, approximately a quarter of 8 th segment; ductus bursae thin and long (more than 20 times of corpus bursae), corpus bursae globular, a pair of oval signa with minute, pointed denticules. Holotype: ♁; W. Java, TNGHS, Sukabumi, Cidahu. 16.I.2007. leg. Sutrisno H & Darmawan. MZB Lepi. 668; MZB. Paratypes: 1 ♀; W. Java, TNGHS, Sukabumi, Cidahu. 15.I.2007. leg. Sutrisno H & Darmawan. MZB. Lepi. 252 (MZB); 1 ♀; W. Java, TNGHS, Bogor, Pamijahan, Garehong, S 06° 44 ʹ E 106° 37. 18 ʹ. VIII.2008. leg. Sutrisno H & Darmawan (MZB); 1 ♀; W. Java, TNGHS, Malasari, G. Kendeng; S 06° 45 ʹ 39 ʺ E 106° 32 ʹ 20 ʺ;. 31.X.2007. leg. Darmawan (MZB); 1 ♀; W. Java, TNGHS, Bogor, Pamijahan, Garehong. 25.VII.2008. leg. Cholik E & Mumu (MZB); 1 ♀; W. Java, TNGHS, Bogor, Malasari, G. Kendeng. S06° 45 ʹ 39 E ʺ 106° 32 ʹ 20. 31 ʺ; X.2007. leg. Darmawan (MZB); 1 ♁; W. Java, TNGHS, Bogor, Ciapus. S 06° 40 ʹ 37 ʺ E 106° 45 ʹ 08 ʺ. 5.X.2009. leg. Sutrisno & Darmawan (MZB); 2 ♁, W. Java, TNGHS, Bogor, G. Bunder. S06° 42 ʹ 24 ʺ E 108° 41 ʹ 22 ʺ; 07.X.2009. leg. Sutrisno H & Darmawan (MZB). Etymology. The specific name halimunensis is derived from the type locality. This new species is endemic to Halimun, West Java. An adjective in the nominative singular. Distribution. Mountain Halimun–Salak National Park (TNGHS), West Java only (Fig. 13). Remark: The male holotype forewing showed damages. The lamellar coremata bundle was damaged during slide mounting due to its soft nature, nevertheless, a small part remains on both sides. The adults were collected using a light trap at altitude> 1400 m above sea level., Published as part of Watung, Jackson F., Darmawan, Darmawan, Suwito, Awit, Narakusumo, Raden Pramesa, Nugroho, Hari, Encilia, Encilia, Qodri, Agmal, Peggie, Djunijanti, Ubaidillah, Rosichon & Sutrisno, Hari, 2023, The genus Agrioglypta Meyrick (Lepidoptera: Crambidae, Spilomelinae) from Indonesia with descriptions of three new species, pp. 569-578 in Zootaxa 5297 (4) on pages 573-577, DOI: 10.11646/zootaxa.5297.4.6, http://zenodo.org/record/8009245, {"references":["Snellen, P. C. T., van der Wulp, F. M. & Everts, J. G. (1894) Tijdschriftvoor Entomologie De Nederlandsche Entomlogische Vereeniging, Jaagrang 1893 - 1894. Martinus Nijhoff, Leiden, 196 pp."]}
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38. The genus Agrioglypta Meyrick (Lepidoptera: Crambidae, Spilomelinae) from Indonesia with descriptions of three new species
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Watung, Jackson F., Darmawan, Darmawan, Suwito, Awit, Narakusumo, Raden Pramesa, Nugroho, Hari, Encilia, Encilia, Qodri, Agmal, Peggie, Djunijanti, Ubaidillah, Rosichon, and Sutrisno, Hari
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Lepidoptera ,Insecta ,Arthropoda ,Animalia ,Crambidae ,Biodiversity ,Taxonomy - Abstract
Watung, Jackson F., Darmawan, Darmawan, Suwito, Awit, Narakusumo, Raden Pramesa, Nugroho, Hari, Encilia, Encilia, Qodri, Agmal, Peggie, Djunijanti, Ubaidillah, Rosichon, Sutrisno, Hari (2023): The genus Agrioglypta Meyrick (Lepidoptera: Crambidae, Spilomelinae) from Indonesia with descriptions of three new species. Zootaxa 5297 (4): 569-578, DOI: 10.11646/zootaxa.5297.4.6, URL: http://dx.doi.org/10.11646/zootaxa.5297.4.6
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- 2023
39. Agrioglypta Meyrick 1932
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Watung, Jackson F., Darmawan, Darmawan, Suwito, Awit, Narakusumo, Raden Pramesa, Nugroho, Hari, Encilia, Encilia, Qodri, Agmal, Peggie, Djunijanti, Ubaidillah, Rosichon, and Sutrisno, Hari
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Lepidoptera ,Insecta ,Arthropoda ,Animalia ,Crambidae ,Agrioglypta ,Biodiversity ,Taxonomy - Abstract
Checklist of Agrioglypta species in Indonesia A. eurytusalis (Walker, 1859) A. excelsalis (Walker, 1866) A. halimunensis Sutrisno sp. nov. A. hastantiae Sutrisno sp. nov. A. itysalis (Walker, 1859) A. jaculalis (Snellen in Snellen et al., 1894) A. naralis (C. Felder & Rogenhofer, 1875) A. ubaidillahi Sutrisno sp. nov. A. zelimalis (Walker, 1859), Published as part of Watung, Jackson F., Darmawan, Darmawan, Suwito, Awit, Narakusumo, Raden Pramesa, Nugroho, Hari, Encilia, Encilia, Qodri, Agmal, Peggie, Djunijanti, Ubaidillah, Rosichon & Sutrisno, Hari, 2023, The genus Agrioglypta Meyrick (Lepidoptera: Crambidae, Spilomelinae) from Indonesia with descriptions of three new species, pp. 569-578 in Zootaxa 5297 (4) on page 570, DOI: 10.11646/zootaxa.5297.4.6, http://zenodo.org/record/8009245, {"references":["Walker, F. (1859) List of the specimens of Lepidopterous insects in the Collection of the British Museum. London, 17, 255 - 508.","Walker, F. (1866) List of the specimens of Lepidopterous insects in the Collection of the British Museum. London, 34, 1121 - 1533.","Snellen, P. C. T., van der Wulp, F. M. & Everts, J. G. (1894) Tijdschriftvoor Entomologie De Nederlandsche Entomlogische Vereeniging, Jaagrang 1893 - 1894. Martinus Nijhoff, Leiden, 196 pp.","Felder, C. & Felder, R. & Rogenhofer, A. F. (1875) Heft 5, Heterocera. In: Felder, C., Felder, R. & Rogenhofer, A. F. (Eds) Reise der osterreichischen Fregatte Novara um die Erde in den Jahren 1857, 1858, 1859 unter den Befehlen des Commodore B. von Wullerstorf-Urbair. Zoologischer Theil, Zweiter Band, Zwete Abtheilung: Lepidoptera. Atlas. K. - k. Hof- und Staatsdruckerei, Wien, pls 121 - 140."]}
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40. Trade-offs between Nutrient Intake and Faecal Avoidance in Herbivore Foraging Decisions: The Effect of Animal Parasitic Status, Level of Feeding Motivation and Sward Nitrogen Content
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Hutchings, M. R., Kyriazakis, I., Gordon, I. J., and Jackson, F.
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- 1999
41. Don't Get Wounded: Military Health System Consolidation and the Risk to Readiness
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Jackson, F. Cameron
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United States. Department of Defense ,Health care industry ,Superconductors ,Metaphysics ,General interest ,Military and naval science - Abstract
Absent some advance in material sciences, physics, or metaphysics, the infantrymen of the future will have to cease their habit of becoming wounded due to enemy action, disease, or nonbattle [...]
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- 2019
42. (052) Are Vibrators Equally Effective Among Women Engaged in Partnered Versus Solo Sexual Activity?
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Dubinskaya, A, primary, Jackson, F, additional, Kohli, P, additional, Shoureshi, P, additional, and Eilber, K, additional
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- 2023
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43. Data from Differential Effects of Depleting versus Programming Tumor-Associated Macrophages on Engineered T Cells in Pancreatic Ductal Adenocarcinoma
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Stromnes, Ingunn M., primary, Burrack, Adam L., primary, Hulbert, Ayaka, primary, Bonson, Patrick, primary, Black, Cheryl, primary, Brockenbrough, J. Scott, primary, Raynor, Jackson F., primary, Spartz, Ellen J., primary, Pierce, Robert H., primary, Greenberg, Philip D., primary, and Hingorani, Sunil R., primary
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- 2023
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44. Supplementary Figures 1-4 from Differential Effects of Depleting versus Programming Tumor-Associated Macrophages on Engineered T Cells in Pancreatic Ductal Adenocarcinoma
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Stromnes, Ingunn M., primary, Burrack, Adam L., primary, Hulbert, Ayaka, primary, Bonson, Patrick, primary, Black, Cheryl, primary, Brockenbrough, J. Scott, primary, Raynor, Jackson F., primary, Spartz, Ellen J., primary, Pierce, Robert H., primary, Greenberg, Philip D., primary, and Hingorani, Sunil R., primary
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- 2023
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45. A dual role of microbiota type 17 immunity in tissue repair and pain
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Austin, Paul J, primary, Karrasch, Jackson F, additional, and O'Brien, Jayden A, additional
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- 2023
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46. Species differences in the induction of cytochrome P4503A
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Jackson, F. C.
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615.19 - Abstract
Species differences in the induction mechanisms of CYP3A isoenzymes were investigated in this project using several structurally different drugs in rat, dog or human in vitro and in vivo models. Induction of CYP3A was assessed by observing the levels of CYP3A activity, CYP3A immunoreactive protein and CYP3A mRNA following drug treatment. Dexamethasone was a potent inducer of CYP3A activity, protein and mRNA in the female rat in vivo and in vitro. The induction of CYP3A by dexamethasone was inhibited by the presence of 5% FCS in rat hepatocytes and a residual inhibitory effect was observed when 5% FCS was used for cell attachment only. The inhibition of CYP3A induction by FCS was not observed in dog or human hepatocytes. Dexamethasone did not induce CYP3A activity in the male or female dog in vivo. Rifampicin was a potent inducer of CYP3A in the dog in vitro, which correlates with the effect of rifampicin on CYP3A in dog in vivo. The ACAT inhibitor, SK&F 98016, induced CYP3A activity and protein in the rat in vivo and in vitro whilst mRNA levels were increased in vivo but not in vitro. The HMGCo-A reductase inhibitors, lovastatin and simvastatin induced CYP3A protein and activity in the rat in vivo but had no effect on CYP3A mRNA levels. Lovastatin and simvastatin did not induce CYP3A in the rat in vitro. Addition of the cholesterol biosynthesis pathway intermediates mevalonate and 25-hydroxycholestrol enhanced the induction of CYP3A by SK&F 98016 in the rat in vitro, suggesting that oxysterols may be involved in the induction of CYP3A by SK&F 98016. Different induction mechanisms are involved between dexamethasone-mediated CYP3A induction and the induction of CYP3a by SK&F 98016 and the statins. Dexamethasone induces CYP3A through an interaction with a 'non-classical' glucocorticoid receptor, whilst SK&F 98016 and the statins inhibit ACAT and HMGCo-A reductase in the cholesterol biosynthesis pathway, leading to an alteration in the level of regulatory oxysterols. This suggests a link between the regulation of the cholesterol biosynthesis pathway and the induction of CYP3A by SK&F 98016 and the statins.
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- 1998
47. Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal Adenocarcinoma
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Adam L. Burrack, Ellen J. Spartz, Jackson F. Raynor, Iris Wang, Margaret Olson, and Ingunn M. Stromnes
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Biology (General) ,QH301-705.5 - Abstract
Summary: Pancreatic ductal adenocarcinoma (PDA) is a lethal cancer resistant to immunotherapy. We create a PDA mouse model and show that neoantigen expression is required for intratumoral T cell accumulation and response to immune checkpoint blockade. By generating a peptide:MHC tetramer, we identify that PDA induces rapid intratumoral, and progressive systemic, tumor-specific T cell exhaustion. Monotherapy PD-1 or PD-L1 blockade enhances systemic T cell expansion and induces objective responses that require systemic T cells. However, tumor escape variants defective in IFNγ-inducible Tap1 and MHC class I cell surface expression ultimately emerge. Combination PD-1 + PD-L1 blockade synergizes therapeutically by increasing intratumoral KLRG1+Lag3−TNFα+ tumor-specific T cells and generating memory T cells capable of expanding to spontaneous tumor recurrence, thereby prolonging animal survival. Our studies support that PD-1 and PD-L1 are relevant immune checkpoints in PDA and identify a combination for clinical testing in those patients with neoantigen-specific T cells. : Burrack et al. investigate tumor-specific T cells during immunotherapy of pancreas cancer. T cells accumulate intratumorally yet rapidly exhaust. Combined PD-1 + PD-L1 blockade promotes peripheral T cell expansion, TNFα production, and eradication of spontaneous tumor recurrence in 50% of animals. Tumor variants defective in IFNγ-inducible Tap1 and MHC class I ultimately emerge. Keywords: pancreatic cancer, PDA, immunotherapy, PD-1, PD-L1, acquired resistance, T cells, neoepitope
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- 2019
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48. Supplementary Figures 1-4 from Differential Effects of Depleting versus Programming Tumor-Associated Macrophages on Engineered T Cells in Pancreatic Ductal Adenocarcinoma
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Sunil R. Hingorani, Philip D. Greenberg, Robert H. Pierce, Ellen J. Spartz, Jackson F. Raynor, J. Scott Brockenbrough, Cheryl Black, Patrick Bonson, Ayaka Hulbert, Adam L. Burrack, and Ingunn M. Stromnes
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Supplementary Figures 1-4
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- 2023
49. Data from Differential Effects of Depleting versus Programming Tumor-Associated Macrophages on Engineered T Cells in Pancreatic Ductal Adenocarcinoma
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Sunil R. Hingorani, Philip D. Greenberg, Robert H. Pierce, Ellen J. Spartz, Jackson F. Raynor, J. Scott Brockenbrough, Cheryl Black, Patrick Bonson, Ayaka Hulbert, Adam L. Burrack, and Ingunn M. Stromnes
- Abstract
Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy resistant to therapies, including immune-checkpoint blockade. We investigated two distinct strategies to modulate tumor-associated macrophages (TAM) to enhance cellular therapy targeting mesothelin in an autochthonous PDA mouse model. Administration of an antibody to colony-stimulating factor (anti-Csf1R) depleted Ly6Clow protumorigenic TAMs and significantly enhanced endogenous T-cell intratumoral accumulation. Despite increasing the number of endogenous T cells at the tumor site, as previously reported, TAM depletion had only minimal impact on intratumoral accumulation and persistence of T cells engineered to express a murine mesothelin-specific T-cell receptor (TCR). TAM depletion interfered with the antitumor activity of the infused T cells in PDA, evidenced by reduced tumor cell apoptosis. In contrast, TAM programming with agonistic anti-CD40 increased both Ly6Chigh TAMs and the intratumoral accumulation and longevity of TCR-engineered T cells. Anti-CD40 significantly increased the frequency and number of proliferating and granzyme B+ engineered T cells, and increased tumor cell apoptosis. However, anti-CD40 failed to rescue intratumoral engineered T-cell IFNγ production. Thus, although functional modulation, rather than TAM depletion, enhanced the longevity of engineered T cells and increased tumor cell apoptosis, ultimately, anti-CD40 modulation was insufficient to rescue key effector defects in tumor-reactive T cells. This study highlights critical distinctions between how endogenous T cells that evolve in vivo, and engineered T cells with previously acquired effector activity, respond to modifications of the tumor microenvironment.
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- 2023
50. THE CANDOR OF STRANGERS
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Brown, Jackson F.
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- 2016
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