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167 results on '"Jackson, Colette E."'

3. Invasive Versus Medical Management in Patients With Prior Coronary Artery Bypass Surgery With a Non-ST Segment Elevation Acute Coronary Syndrome: A Pilot Randomized Controlled Trial

Author

Lee, Matthew M.Y., Petrie, Mark C., Rocchiccioli, Paul, Simpson, Joanne, Jackson, Colette E., Corcoran, David S., Mangion, Kenneth, Brown, Ammani, Cialdella, Pio, Sidik, Novalia P., McEntegart, Margaret B., Shaukat, Aadil, Rae, Alan P., Hood, Stuart H.M., Peat, Eileen E., Findlay, Iain N., Murphy, Clare L., Cormack, Alistair J., Bukov, Nikolay B., Balachandran, Kanarath P., Oldroyd, Keith G., Ford, Ian, Wu, Olivia, McConnachie, Alex, Barry, Sarah J.E., and Berry, Colin

Published
2019
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8. Adherence to prescribed medications in patients with heart failure – insights from liquid chromatography-tandem mass spectrometry-based urine analysis

Author

Simpson, Joanne, Jackson, Colette E., Haig, Caroline, Jhund, Pardeep S., Tomaszewski, Maciej, Gardner, Roy S., Tsorlalis, Yannis, Petrie, Mark C., McMurray, John J.V., Squire, Iain B., and Gupta, Pankaj

Abstract

Aims: \ud None of the existing studies on adherence have directly measured levels of medications (or their metabolites) in patients with heart failure.\ud \ud Methods and Results: \ud We used liquid chromatography-tandem mass spectrometry to measure the presence of prescribed drugs (diuretics, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers and mineralocorticoid receptor antagonists) in the urine of patients reviewed 4 to 6 weeks after hospitalisation with heart failure. Patients were unaware that adherence was being assessed. Of the 341 patients studied, 281 (82.4%) were adherent i.e. had all prescribed drugs of interest detectable in their urine. Conversely, 60 patients (17.6%) were partially or completely non-adherent. Notably, 24 of the 60 were non-adherent to only diuretic therapy and only 7 out of all 341 patients studied (2.1%) were completely non-adherent to all prescribed heart failure drugs. There were no major differences in baseline characteristics between adherent and non-adherent patients.\ud \ud Conclusion: \ud Non-adherence, assessed using a single spot urine measurement of drug levels, was confirmed in 1 of 5 patients evaluated 4 to 6 weeks after hospitalisation with heart failure.

Published
2021

10. Differing prognostic value of pulse pressure in patients with heart failure with reduced or preserved ejection fraction: results from the MAGGIC individual patient meta-analysis

Author

Jackson, Colette E., Castagno, Davide, Maggioni, Aldo P., Køber, Lars, Squire, Iain B., Swedberg, Karl, Andersson, Bert, Richards, A. Mark, Bayes-Genis, Antoni, Tribouilloy, Christophe, Dobson, Joanna, Ariti, Cono A., Poppe, Katrina K., Earle, Nikki, Whalley, Gillian, Pocock, Stuart J., Doughty, Robert N., McMurray, John J.V., Berry, C., Doughty, R., Granger, C., Køber, L., Massie, B., McAlister, F., McMurray, J., Pocock, S., Poppe, K., Swedberg, K., Somaratne, J., Whalley, G., Ahmed, A., Andersson, B., Bayes-Genis, A., Berry, C., Cowie, M., Cubbon, R., Doughty, R., Ezekowitz, J., Gonzalez-Juanatey, J., Gorini, M., Gotsman, I., Grigorian-Shamagian, L., Guazzi, M., Kearney, M., Køber, L., Komajda, M., di Lenarda, A., Lenzen, M., Lucci, D., Macín, S., Madsen, B., Maggioni, A., Martínez-Sellés, M., McAlister, F., Oliva, F., Poppe, K., Rich, M., Richards, M., Senni, M., Squire, I., Taffet, G., Tarantini, L., Tribouilloy, C., Troughton, R., Tsutsui, H., Whalley, G., Doughty, R., Earle, N., Gamble, G.D., Poppe, K., Whalley, G., Ariti, C., Dobson, J., Pocock, S., Poppe, K., Doughty, R.N., Whalley, G., Andersson, B., Hall, C., Richards, A.M., Troughton, R., Lainchbury, J., Berry, C., Hogg, K., Norrie, J., Stevenson, K., Brett, M., McMurray, J., Pfeffer, M.A., Swedberg, K., Granger, C.B., Held, P., McMurray, J.J.V., Michelson, E.L., Olofsson, B., Östergren, J., Yusuf, S., Køber, L., Torp-Pedersen, C., Lenzen, M.J., Scholte op Reimer, W.J.M., Boersma, E., Vantrimpont, P.J.M.J., Follath, F., Swedberg, K., Cleland, J., Komajda, M., Gotsman, I., Zwas, D., Planer, D., Azaz-Livshits, T., Admon, D., Lotan, C., Keren, A., Grigorian-Shamagian, L., Varela-Roman, A., Mazón-Ramos, P., Rigeiro-Veloso, P., Bandin-Dieguez, M.A., Gonzalez-Juanatey, J.R., Guazzi, M., Myers, J., Arena, R., McAlister, F.A., Ezekowitz, J., Armstrong, P.W., Cujec, Bibiana, Paterson, Ian, Cowie, M.R., Wood, D.A., Coats, A.J.S., Thompson, S.G., Suresh, V., Poole-Wilson, P.A., Sutton, G.C., Martínez-Sellés, M., Robles, J.A.G., Prieto, L., Muñoa, M.D., Frades, E., Díaz-Castro, O., Almendral, J., Tarantini, L., Faggiano, P., Senni, M., Lucci, D., Bertoli, D., Porcu, M., Opasich, C., Tavazzi, L., Maggioni, A.P., Kirk, V., Bay, M., Parner, J., Krogsgaard, K., Herzog, T.M., Boesgaard, S., Hassager, C., Nielsen, O.W., Aldershvile, J., Nielsen, H., Kober, L., Macín, S.M., Perna, E.R., Cimbaro Canella, J.P., Alvarenga, P., Pantich, R., Ríos, N., Farias, E.F., Badaracco, J.R., Madsen, B.K., Hansen, J.F., Stokholm, K.H., Brons, J., Husum, D., Mortensen, L.S., Bayes-Genis, A., Vazquez, R., Puig, T., Fernandez-Palomeque, C., Bardají, A., Pascual-Figal, D., Ordoñez-Llanos, J., Valdes, M., Gabarrus, A., Pavon, R., Pastor, L., Gonzalez-Juanatey, J.R., Almendral, J., Fiol, M., Nieto, V., Macaya, C., Cinca, J., Cygankiewitz, I., Bayes de Luna, A., Newton, J.D., Blackledge, H.M., Squire, I.B., Wright, S.P., Whalley, G.A., Doughty, R.N., Kerzner, R., Gage, B.F., Freedland, K.E., Rich, M.W., Huynh, B.C., Rovner, A., Freedland, K.E., Carney, R.M., Rich, M.W., Taffet, G.E., Teasdale, T.A., Bleyer, A.J., Kutka, N.J., Luchi, R.J., Tribouilloy, C., Rusinaru, D., Mahjoub, H., Soulière, V., Lévy, F., Peltier, M., Tsutsui, H., Tsuchihashi, M., Takeshita, A., MacCarthy, P.A., Kearney, M.T., Nolan, J., Lee, A.J., Prescott, R.J., Shah, A.M., Brooksby, W.P., Fox, K.A.A., Varela-Roman, A., Gonzalez-Juanatey, J.R., Basante, P., Trillo, R., Garcia-Seara, J., Martinez-Sande, J.L., and Gude, F.

Published
2015
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13. Urinary peptides in heart failure: a link to molecular pathophysiology

Author

He, Tianlin, primary, Mischak, Michaela, additional, Clark, Andrew L., additional, Campbell, Ross T., additional, Delles, Christian, additional, Díez, Javier, additional, Filippatos, Gerasimos, additional, Mebazaa, Alexandre, additional, McMurray, John J.V., additional, González, Arantxa, additional, Raad, Julia, additional, Stroggilos, Rafael, additional, Bosselmann, Helle S., additional, Campbell, Archie, additional, Kerr, Shona M., additional, Jackson, Colette E., additional, Cannon, Jane A., additional, Schou, Morten, additional, Girerd, Nicolas, additional, Rossignol, Patrick, additional, McConnachie, Alex, additional, Rossing, Kasper, additional, Schanstra, Joost P., additional, Zannad, Faiez, additional, Vlahou, Antonia, additional, Mullen, William, additional, Jankowski, Vera, additional, Mischak, Harald, additional, Zhang, Zhenyu, additional, Staessen, Jan A., additional, and Latosinska, Agnieszka, additional

Published
2021
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19. Invasive versus medically managed acute coronary syndromes with prior bypass (CABG-ACS): insights into the registry versus randomised trial populations

Author

Lee, Matthew M Y, primary, Petrie, Mark C, additional, Rocchiccioli, Paul, additional, Simpson, Joanne, additional, Jackson, Colette E, additional, Corcoran, David S, additional, Mangion, Kenneth, additional, Brown, Ammani, additional, Cialdella, Pio, additional, Sidik, Novalia P, additional, McEntegart, Margaret B, additional, Shaukat, Aadil, additional, Rae, Alan P, additional, Hood, Stuart H M, additional, Peat, Eileen E, additional, Findlay, Iain N, additional, Murphy, Clare L, additional, Cormack, Alistair J, additional, Bukov, Nikolay B, additional, Balachandran, Kanarath P, additional, Ford, Ian, additional, Wu, Olivia, additional, McConnachie, Alex, additional, Barry, Sarah J E, additional, and Berry, Colin, additional

Published
2021
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27. Adherence to prescribed medications in patients with heart failure: insights from liquid chromatography–tandem mass spectrometry-based urine analysis

Author

Simpson, Joanne, primary, Jackson, Colette E, additional, Haig, Caroline, additional, Jhund, Pardeep S, additional, Tomaszewski, Maciej, additional, Gardner, Roy S, additional, Tsorlalis, Yannis, additional, Petrie, Mark C, additional, McMurray, John J V, additional, Squire, Iain B, additional, and Gupta, Pankaj, additional

Published
2020
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28. The novel urinary proteomic classifier HF1 has similar diagnostic and prognostic utility to BNP in heart failure

Author

Campbell, Ross T., primary, Jasilek, Adam, additional, Mischak, Harald, additional, Nkuipou‐Kenfack, Esther, additional, Latosinska, Agnieszka, additional, Welsh, Paul I., additional, Jackson, Colette E., additional, Cannon, Jane, additional, McConnachie, Alex, additional, Delles, Christian, additional, and McMurray, John J.V., additional

Published
2020
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34. Which patients with heart failure should receive specialist palliative care?

Author

Campbell, Ross T., Petrie, Mark C., Jackson, Colette E., Jhund, Pardeep S., Wright, Ann, Gardner, Roy S., Sonecki, Piotr, Pozzi, Andrea, McSkimming, Paula, McConnachie, Alex, Finlay, Fiona, Davidson, Patricia, Denvir, Martin A., Johnson, Miriam J., Hogg, Karen J., and McMurray, John J.V.

Subjects
Aged, 80 and over, Male, Heart Failure, animal structures, Patient Selection, Palliative Care, fungi, United Kingdom, Hospitalization, Treatment, Cardiovascular System & Hematology, Prevalence, Quality of Life, Humans, Female, Patient Reported Outcome Measures, 1102 Cardiorespiratory Medicine and Haematology, Aged, Follow-Up Studies, Retrospective Studies, Specialization, Research Article
Abstract

Aims:\ud \ud We investigated which patients with heart failure (HF) should receive specialist palliative care (SPC) by first creating a definition of need for SPC in patients hospitalised with HF using patient‐reported outcome measures (PROMs) and then testing this definition using the outcome of days alive and out of hospital (DAOH). We also evaluated which baseline variables predicted need for SPC and whether those with this need received SPC.\ud Methods and results:\ud \ud PROMs assessing quality of life (QoL), symptoms, and mood were administered at baseline and every 4 months. SPC need was defined as persistently severe impairment of any PROM without improvement (or severe impairment immediately preceding death). We then tested whether need for SPC, so defined, was reflected in DAOH, a measure which combines length of stay, days of hospital re‐admission, and days lost due to death. Of 272 patients recruited, 74 (27%) met the definition of SPC needs. These patients lived one third fewer DAOH than those without SPC need (and less than a quarter of QoL‐adjusted DAOH). A Kansas City Cardiomyopathy Questionnaire (KCCQ) summary score of

Published
2018

37. The incremental prognostic and clinical value of multiple novel biomarkers in heart failure

Author

Jackson, Colette E., Haig, Caroline, Welsh, Paul, Dalzell, Jonathan R., Tsorlalis, Ioannis K., McConnachie, Alex, Preiss, David, Anker, Stefan D., Sattar, Naveed, Petrie, Mark C., Gardner, Roy S., and McMurray, John J. V.

Subjects
heart failure, prognosis, risk stratification, novel biomarkers
Abstract

Aims: In recent years there has been an increase in the number of biomarkers in heart failure ( HF ). The clinical role for these novel biomarkers in combination is not clear. Methods and results: The following novel biomarkers were measured from 628 patients recently hospitalized with decompensated HF; mid-regional pro-adrenomedullin ( MR-proADM ), mid-regional pro-atrial natriuretic peptide ( MR-proANP ), copeptin, high-sensitivity cardiac troponin T ( hs-cTnT ), ST2, galectin-3, cystatin C, combined free light chains ( cFLC ) and high sensitivity C-reactive protein ( hsCRP ). The incremental prognostic value of these novel biomarkers was evaluated within an extensive model containing established predictors of mortality. During a mean ( SD ) follow-up of 3.2 ( 1.5 ) years, 290 ( 46% ) patients died. Elevated concentrations of all novel biomarkers were associated with an increased unadjusted risk of mortality but only two-thirds were independent predictors following multivariable analysis. Using dichotomized cut-points from receiver operating characteristic analysis, MR-proADM, hs-cTnT, cFLC, hsCRP, and ST2 remained independent predictors of mortality. Further dichotomization into low ( 0–2 elevated biomarkers ) or high ( at least three of the five biomarkers elevated ) risk groups provided greatest incremental prognostic value ( hazard ratio 2.20, 95% confidence interval 1.37–3.54; P = 0.001 ) and improved the performance of the model ( C-statistic 0.730 from 0.721, net reclassification index 32.5% ). Conclusion: The novel biomarkers included in this study added little, if any, incremental prognostic value on their own to a model containing established predictors of mortality. However, following dichotomization, five of the novel biomarkers provided incremental prognostic value. There was a clear gradient in the risk of death with increasing numbers of elevated novel biomarkers, with the presence of at least three identifying patients at greatest risk of mortality.

Published
2016

41. The heart in an airbag

Author

Castagno, Davide, primary, Dalzell, Jonathan R., additional, Jackson, Colette E., additional, Neisius, Ulf, additional, Cormack, Alistair, additional, and Gaita, Fiorenzo, additional

Published
2012
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50. Adherence to prescribed medications in patients with heart failure: insights from liquid chromatography-tandem mass spectrometry-based urine analysis.

Author

Simpson J, Jackson CE, Haig C, Jhund PS, Tomaszewski M, Gardner RS, Tsorlalis Y, Petrie MC, McMurray JJV, Squire IB, and Gupta P

Subjects
Angiotensin Receptor Antagonists therapeutic use, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Chromatography, Liquid, Humans, Heart Failure diagnosis, Heart Failure drug therapy, Tandem Mass Spectrometry
Abstract

Aims: None of the existing studies on adherence have directly measured levels of all medications (or their metabolites) in patients with heart failure (HF)., Methods and Results: We used liquid chromatography-tandem mass spectrometry to measure the presence of prescribed drugs (diuretics, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, and mineralocorticoid receptor antagonists) in the urine of patients reviewed 4-6 weeks after hospitalization with HF. Patients were unaware that adherence was being assessed. Of the 341 patients studied, 281 (82.4%) were adherent, i.e. had all prescribed drugs of interest detectable in their urine. Conversely, 60 patients (17.6%) were partially or completely non-adherent. Notably, 24 of the 60 were non-adherent to only diuretic therapy and only seven out of all 341 patients studied (2.1%) were completely non-adherent to all prescribed HF drugs. There were no major differences in baseline characteristics between adherent and non-adherent patients., Conclusion: Non-adherence, assessed using a single spot urine measurement of drug levels, was confirmed in one of five patients evaluated 4-6 weeks after hospitalization with HF., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.)

Published
2021
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