9,316 results on '"Jackson, B"'
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2. The Avon and Third Stage
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Jackson, B. W.
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- 2018
3. Stratford’s Avon Theatre and Third Stage, 1973
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Jackson, B. W.
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- 2018
4. Two comments on the Stratford season: II: Contemporary Theatre at the Avon
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Jackson, B. W.
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- 2018
5. Two views of Stratford: II: At the Avon
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Jackson, B. W.
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- 2018
6. System performance of a TDM test-bed with long flex harness towards the new X-IFU FPA-DM
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Vaccaro, D., de Wit, M., van der Kuur, J., Gottardi, L., Ravensberg, K., Taralli, E., Adams, J., Bandler, S. R., Chervenak, J. A., Doriese, W. B., Durkin, M., Reintsema, C., Sakai, K., Smith, S. J., Wakeham, N. A., Jackson, B., Khosropanah, P., Gao, J. R., Herder, J. W. A. den, and Roelfsema, P.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
SRON (Netherlands Institute for Space Research) is developing the Focal Plane Assembly (FPA) for Athena X-IFU, whose Demonstration Model (DM) will use for the first time a time domain multiplexing (TDM)-based readout system for the on-board transition-edge sensors (TES). We report on the characterization activities on a TDM setup provided by NASA Goddard Space Flight Center (GSFC) and National Institute for Standards and Technology (NIST) and tested in SRON cryogenic test facilities. The goal of these activities is to study the impact of the longer harness, closer to X-IFU specs, in a different EMI environment and switching from a single-ended to a differential readout scheme. In this contribution we describe the advancement in the debugging of the system in the SRON cryostat, which led to the demonstration of the nominal spectral performance of 2.8 eV at 5.9~keV with 16-row multiplexing, as well as an outlook for the future endeavours for the TDM readout integration on X-IFU's FPA-DM at SRON., Comment: Under publication in Journal of Low Temperature Physics
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- 2024
7. Power Consumption in SQUID Multiplexers for Space-Based Applications
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van der Kuur, J., Kiviranta, M., de Lange, G., Vaccaro, D., de Wit, M., Gottardi, L. G., Akamatsu, H. A., Jackson, B. D., Nagayoshi, K., Bruijn, M. P., Taralli, E., Ravensberg, K., and den Herder, J. W. A.
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- 2024
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8. Regional Heterogeneity in Intestinal Epithelial Barrier Permeability and Mesenteric Perfusion After Thoracic Spinal Cord Injury
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Radler, Jackson B., McBride, Amanda R., Saha, Kushal, Nighot, Prashant, and Holmes, Gregory M.
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- 2024
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9. Piling up multidecker pyrgos[n]cages as antibacterial materials
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Liuzzi-Vaamonde, Miguel A., Lancaster, Jackson B., Mason, Samantha A., and Feng, Yuanning
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- 2024
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10. Literacy Studies
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Bagnani, G., Berry, E. G., Blake, N. F., Foulet, Alfred, MacLure, Millar, Love, C. C., Leech, Clifford, Jackson, B. A. W., MacLure, Millar, Raymond, W. O., and Carroll, John
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- 2015
11. CME Propagation Through the Heliosphere: Status and Future of Observations and Model Development
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Temmer, M., Scolini, C., Richardson, I. G., Heinemann, S. G., Paouris, E., Vourlidas, A., Bisi, M. M., teams, writing, Al-Haddad, N., Amerstorfer, T., Barnard, L., Buresova, D., Hofmeister, S. J., Iwai, K., Jackson, B. V., Jarolim, R., Jian, L. K., Linker, J. A., Lugaz, N., Manoharan, P. K., Mays, M. L., Mishra, W., Owens, M. J., Palmerio, E., Perri, B., Pomoell, J., Pinto, R. F., Samara, E., Singh, T., Sur, D., Verbeke, C., Veronig, A. M., and Zhuang, B.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Physics - Space Physics - Abstract
The ISWAT clusters H1+H2 have a focus on interplanetary space and its characteristics, especially on the large-scale co-rotating and transient structures impacting Earth. SIRs, generated by the interaction between high-speed solar wind originating in large-scale open coronal magnetic fields and slower solar wind from closed magnetic fields, are regions of compressed plasma and magnetic field followed by high-speed streams that recur at the ca. 27 day solar rotation period. Short-term reconfigurations of the lower coronal magnetic field generate flare emissions and provide the energy to accelerate enormous amounts of magnetised plasma and particles in the form of CMEs into interplanetary space. The dynamic interplay between these phenomena changes the configuration of interplanetary space on various temporal and spatial scales which in turn influences the propagation of individual structures. While considerable efforts have been made to model the solar wind, we outline the limitations arising from the rather large uncertainties in parameters inferred from observations that make reliable predictions of the structures impacting Earth difficult. Moreover, the increased complexity of interplanetary space as solar activity rises in cycle 25 is likely to pose a challenge to these models. Combining observational and modeling expertise will extend our knowledge of the relationship between these different phenomena and the underlying physical processes, leading to improved models and scientific understanding and more-reliable space-weather forecasting. The current paper summarizes the efforts and progress achieved in recent years, identifies open questions, and gives an outlook for the next 5-10 years. It acts as basis for updating the existing COSPAR roadmap by Schrijver+ (2015), as well as providing a useful and practical guide for peer-users and the next generation of space weather scientists., Comment: Accepted for publication in Advances in Space Research
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- 2023
12. Anticancer Activity of 4-Aryl-1,4-Dihydropyridines
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Thaís A. S. Oliveira, Jackson B. A. Silva, Tábata R. Esperandim, Nathália O. Acésio, Denise C. Tavares, and Antônio E. M. Crotti
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Hantzsch esters ,HeLa 229 ,human breast carcinoma ,polyhydroquinolines ,Therapeutics. Pharmacology ,RM1-950 - Abstract
We have synthesized 22 symmetric and asymmetric 4-aryl-1,4-dihydropyridines (1,4-DHPs) by a “green” microwave-assisted one-pot multicomponent Hantzsch reaction and evaluated their cytotoxicity to three human cancer cell lines regarding U-251MG (human glioblastoma), HeLa 229 (human cervical adenocarcinoma), and MCF-7 (human breast carcinoma). None of the 1,4-DHPs were cytotoxic to U-251MG cells. Most of the 1,4-DHPs did not affect HeLa 229 or MCF-7 cell viability. On the other hand, symmetric 1,4-DHPs 18 (diethyl 4-(4-benzyloxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate), 19 (diethyl 4-(4-bromophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate), and 20 (diethyl 4-(3-fluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate) reduced the HeLa (IC50 = 3.6, 2.3, and 4.1 µM, respectively) and MCF-7 (IC50 = 5.2, 5.7, and 11.9 µM, respectively) cell viability. These 1,4-DHPs were more cytotoxic to the HeLa and MCF-7 cells than to the GM07492 (normal human fibroblast) cells, as evidenced by their selectivity indexes. Therefore,1,4-DHPs 18, 19, and 20 may serve as novel lead compounds to discover other 1,4-DHP derivatives with improved anticancer potency and selectivity.
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- 2024
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13. Validation of heliospheric modeling algorithms through pulsar observations I: Interplanetary scintillation-based tomography
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Tiburzi, C., Jackson, B. V., Cota, L., Shaifullah, G. M., Fallows, R. A., Tokumaru, M., and Zucca, P.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,Physics - Space Physics - Abstract
Solar-wind 3-D reconstruction tomography based on interplanetary scintillation (IPS) studies provides fundamental information for space-weather forecasting models, and gives the possibility to determine heliospheric column densities. Here we compare the time series of Solar-wind column densities derived from long-term observations of pulsars, and the Solar-wind reconstruction provided by the UCSD IPS tomography. This work represents a completely independent comparison and validation of these techniques to provide this measurement, and it strengthens confidence in the use of both in space-weather analyses applications., Comment: Published in Journal of Advances in Space Research
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- 2023
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14. DeepDOF-SE: affordable deep-learning microscopy platform for slide-free histology
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Jin, Lingbo, Tang, Yubo, Coole, Jackson B., Tan, Melody T., Zhao, Xuan, Badaoui, Hawraa, Robinson, Jacob T., Williams, Michelle D., Vigneswaran, Nadarajah, Gillenwater, Ann M., Richards-Kortum, Rebecca R., and Veeraraghavan, Ashok
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- 2024
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15. Gratitude Buffers Against the Effects of Stressful Life Events on Adolescents’ Externalizing Behavior but Not Internalizing Behavior
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Webb, Mimi S., Whitmire, Jackson B., Hills, Kimberly J., and Huebner, E. Scott
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- 2024
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16. The Multiview Observatory for Solar Terrestrial Science (MOST)
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Gopalswamy, N., Christe, S., Fung, S. F., Gong, Q., Gruesbeck, J. R., Jian, L. K., Kanekal, S. G., Kay, C., Kucera, T. A., Leake, J. E., Li, L., Makela, P., Nikulla, P., Reginald, N. L., Shih, A., Tadikonda, S. K., Viall, N., Wilson III, L. B., Yashiro, S., Golub, L., DeLuca, E., Reeves, K., Sterling, A. C., Winebarger, A. R., DeForest, C., Hassler, D. M., Seaton, D. B., Desai, M. I., Mokashi, P. S., Lazio, J., Jensen, E. A., Manchester, W. B., Sachdeva, N., Wood, B., Kooi, J., Hess, P., Wexler, D. B., Bale, S. D., Krucker, S., Hurlburt, N., DeRosa, M., Gosain, S., Jain, K., Kholikov, S., Petrie, G. J. D., Pevtsov, A., Tripathy, S. C., Zhao, J., Scherrer, P. H., Rajaguru, S. P., Woods, T., Kenney, M., Zhang, J., Scolini, C., Cho, K. S., Park, Y. D., and Jackson, B. V.
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Astrophysics - Solar and Stellar Astrophysics ,Physics - Space Physics - Abstract
We report on a study of the Multiview Observatory for Solar Terrestrial Science (MOST) mission that will provide comprehensive imagery and time series data needed to understand the magnetic connection between the solar interior and the solar atmosphere/inner heliosphere. MOST will build upon the successes of SOHO and STEREO missions with new views of the Sun and enhanced instrument capabilities. This article is based on a study conducted at NASA Goddard Space Flight Center that determined the required instrument refinement, spacecraft accommodation, launch configuration, and flight dynamics for mission success. MOST is envisioned as the next generation great observatory positioned to obtain three-dimensional information of large-scale heliospheric structures such as coronal mass ejections, stream interaction regions, and the solar wind itself. The MOST mission consists of 2 pairs of spacecraft located in the vicinity of Sun-Earth Lagrange points L4 (MOST1, MOST3) and L5 (MOST2 and MOST4). The spacecraft stationed at L4 (MOST1) and L5 (MOST2) will each carry seven remote-sensing and three in-situ instrument suites, including a novel radio package known as the Faraday Effect Tracker of Coronal and Heliospheric structures (FETCH). MOST3 and MOST4 will carry only the FETCH instruments and are positioned at variable locations along the Earth orbit up to 20{\deg} ahead of L4 and 20{\deg} behind L5, respectively. FETCH will have polarized radio transmitters and receivers on all four spacecraft to measure the magnetic content of solar wind structures propagating from the Sun to Earth using the Faraday rotation technique. The MOST mission will be able to sample the magnetized plasma throughout the Sun-Earth connected space during the mission lifetime over a solar cycle., Comment: 42 pages, 19 figures, 8 tables, to appear in J. Atmospheric and Solar Terrestrial Physics
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- 2023
17. Clinical and Economic Value of a Biosimilar Portfolio to Stakeholders: An Integrative Literature Review
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Fox GE, Bernauer M, Stephens JM, Jackson B, Roth JA, and Shelbaya A
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biosimilar ,portfolio ,value ,Medicine (General) ,R5-920 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Grace E Fox,1 Mark Bernauer,1 Jennifer M Stephens,1 Bianca Jackson,1 Joshua A Roth,2 Ahmed Shelbaya2,3 1Strategic Market Access, OPEN Health, Bethesda, MD, USA; 2Global Access and Value, Pfizer Inc., New York, NY, USA; 3Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USACorrespondence: Mark Bernauer, Strategic Market Access, OPEN Health, Bethesda, MD, USA, Tel +1 240 821-1292, Email markbernauer@openhealthgroup.comPurpose: While the value of individual biosimilars is evident, little is known about the value of a biosimilar portfolio beyond the cost savings between biosimilars and originators. Stakeholders may consider the value of a manufacturer’s biosimilar portfolio, especially when negotiating portfolio-based contracts or other rebate programs. However, little is known about what other types of value, in addition to financial benefits, decision-makers perceive regarding a manufacturer with a biosimilar portfolio compared to those without one. The objective of this integrative literature review was to describe a conceptual framework consisting of themes that may help define the value of a biosimilar portfolio.Methods: An integrative literature review was conducted using Excerpta Medica Database (Embase) and Medical Literature Analysis and Retrieval System Online (MEDLINE). Grey literature searches of search engines, journals not indexed in Embase or MEDLINE, healthcare payers, health technology assessment bodies, value frameworks, and non-pharmaceutical industry analogs were also conducted. Eligible studies reported on the value of a biosimilar portfolio in decision-making by stakeholders. Apart from the literature, insights were gained from clinical experience and observation.Results: No studies investigating biosimilar portfolio value were identified; however, several themes were identified that may help define the value of a biosimilar portfolio: Manufacturing; procurement, inventory, and storage; administration; education; and transaction costs. Several non-pharmaceutical industry analogs were identified: Product line length and single-supplier versus multiple-supplier procurement. Several themes were identified through other sources: Science credibility and research. Based on these themes, we developed a conceptual framework for biosimilar portfolio value.Conclusion: To our knowledge, this is the first study to systematically assess and create a framework for biosimilar portfolio value. The conceptual framework described here could be tested to quantify the clinical and economic value associated with a biosimilar portfolio.Plain Language Summary: Though the value of single biosimilars is evident, little is known about the value of a biosimilar portfolio beyond the cost savings incurred between biosimilars and originators.We identified seven themes that may help to define the value of a biosimilar portfolio: Manufacturing; procurement, inventory, and storage; administration; education; transaction costs; science credibility; and research.These themes may be integrated into a conceptual framework that may form a basis to help quantify the clinical and economic benefit of a biosimilar portfolio to stakeholders.Keywords: biosimilar, portfolio, value, analog
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- 2024
18. Signal Readout for Transition-Edge Sensor X-ray Imaging Spectrometers
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Akamatsu, H., Doriese, W. B., Mates, J. A. B., Jackson, B. D., Bambi, Cosimo, editor, and Santangelo, Andrea, editor
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- 2024
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19. Application of Novel Interplanetary Scintillation Visualisations using LOFAR: A Case Study of Merged CMEs from September 2017
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Fallows, R. A., Iwai, K., Jackson, B. V., Zhang, P., Bisi, M. M., and Zucca, P.
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Astrophysics - Solar and Stellar Astrophysics ,Physics - Space Physics - Abstract
Observations of interplanetary scintillation (IPS - the scintillation of compact radio sources due to density variations in the solar wind) enable the velocity of the solar wind to be determined, and its bulk density to be estimated, throughout the inner heliosphere. A series of observations using the Low Frequency Array (LOFAR - a radio telescope centred on the Netherlands with stations across Europe) were undertaken using this technique to observe the passage of an ultra-fast CME which launched from the Sun following the X-class flare of 10 September 2017. LOFAR observed the strong radio source 3C147 at an elongation of 82 degrees from the Sun over a period of more than 30 hours and observed a strong increase in speed to 900km/s followed two hours later by a strong increase in the level of scintillation, interpreted as a strong increase in density. Both speed and density remained enhanced for a period of more than seven hours, to beyond the period of observation. Further analysis of these data demonstrates a view of magnetic-field rotation due to the passage of the CME, using advanced IPS techniques only available to a unique instrument such as LOFAR., Comment: Accepted for publication in Advances in Space Research, 17 pages, 18 figures
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- 2022
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20. Signal readout for Transition-Edge Sensor X-ray imaging spectrometers
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Akamatsu, H., Doriese, W. B., Mates, J. A. B., and Jackson, B. D.
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Astrophysics - Instrumentation and Methods for Astrophysics ,High Energy Physics - Experiment - Abstract
Arrays of low-temperature microcalorimeters provide a promising technology for X-ray astrophysics: the imaging spectrometer. A camera with at least several thousand pixels, each of which has an energy-resolving power ($E/\Delta E\urss{FWHM}$) of a few thousand across a broad energy range (200~eV to 10~keV or higher), would be a revolutionary instrument for the study of energetic astrophysical objects and phenomena. Signal readout is a critical enabling technology. Multiplexed readout, in which signals from multiple pixels are combined into a single amplifier channel, allows a kilo pixel-scale microcalorimeter array to meet the stringent requirements for power consumption, mass, volume, and cooling capacity in orbit. This chapter describes three different multiplexed-readout technologies for transition-edge-sensor microcalorimeters: time-division multiplexing, frequency-domain multiplexing, and microwave-SQUID multiplexing. For each multiplexing technique, we present the basic method, discuss some design considerations and parameters, and show the state of the art. The chapter concludes with a brief discussion of future prospects., Comment: 50 pages, 23 figures. This Chapter will appear in the Section "Detectors for X-ray Astrophysics" (Section Editors: J-W. den Harder, M. Feroci, N. Meidinger) of the "Handbook of X-ray and Gamma-ray Astrophysics" (Editors in chief: C. Bambi and A. Santangelo)
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- 2022
21. DeepDOF-SE: affordable deep-learning microscopy platform for slide-free histology
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Lingbo Jin, Yubo Tang, Jackson B. Coole, Melody T. Tan, Xuan Zhao, Hawraa Badaoui, Jacob T. Robinson, Michelle D. Williams, Nadarajah Vigneswaran, Ann M. Gillenwater, Rebecca R. Richards-Kortum, and Ashok Veeraraghavan
- Subjects
Science - Abstract
Abstract Histopathology plays a critical role in the diagnosis and surgical management of cancer. However, access to histopathology services, especially frozen section pathology during surgery, is limited in resource-constrained settings because preparing slides from resected tissue is time-consuming, labor-intensive, and requires expensive infrastructure. Here, we report a deep-learning-enabled microscope, named DeepDOF-SE, to rapidly scan intact tissue at cellular resolution without the need for physical sectioning. Three key features jointly make DeepDOF-SE practical. First, tissue specimens are stained directly with inexpensive vital fluorescent dyes and optically sectioned with ultra-violet excitation that localizes fluorescent emission to a thin surface layer. Second, a deep-learning algorithm extends the depth-of-field, allowing rapid acquisition of in-focus images from large areas of tissue even when the tissue surface is highly irregular. Finally, a semi-supervised generative adversarial network virtually stains DeepDOF-SE fluorescence images with hematoxylin-and-eosin appearance, facilitating image interpretation by pathologists without significant additional training. We developed the DeepDOF-SE platform using a data-driven approach and validated its performance by imaging surgical resections of suspected oral tumors. Our results show that DeepDOF-SE provides histological information of diagnostic importance, offering a rapid and affordable slide-free histology platform for intraoperative tumor margin assessment and in low-resource settings.
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- 2024
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22. ATHENA X-IFU Demonstration Model: First joint operation of the main TES Array and its Cryogenic AntiCoincidence Detector (CryoAC)
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D'Andrea, M., Ravensberg, K., Argan, A., Brienza, D., Lotti, S., Macculi, C., Minervini, G., Piro, L., Torrioli, G., Chiarello, F., Barusso, L. Ferrari, Biasotti, M., Gallucci, G., Gatti, F., Rigano, M., Akamatsu, H., Dercksen, J., Gottardi, L., de Groote, F., Hartog, R. den, Herder, J. -W. den, Hoogeveen, R., Jackson, B., McCalden, A., Rosman, S., Taralli, E., Vaccaro, D., de Wit, M., Chervenak, J., Smith, S., and Wakeham, N.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Instrumentation and Detectors - Abstract
The X-IFU is the cryogenic spectrometer onboard the future ATHENA X-ray observatory. It is based on a large array of TES microcalorimeters, which works in combination with a Cryogenic AntiCoincidence detector (CryoAC). This is necessary to reduce the particle background level thus enabling part of the mission science goals. Here we present the first joint test of X-IFU TES array and CryoAC Demonstration Models, performed in a FDM setup. We show that it is possible to operate properly both detectors, and we provide a preliminary demonstration of the anti-coincidence capability of the system achieved by the simultaneous detection of cosmic muons., Comment: Accepted for publication in the Journal of Low Temperature Physics for LTD-19 special issue
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- 2022
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23. Multiscale Optical Imaging Fusion for Cervical Precancer Diagnosis: Integrating Widefield Colposcopy and High-Resolution Endomicroscopy.
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David J. Brenes, Mila P. Salcedo, Jackson B. Coole, Yajur Maker, Alex Kortum, Richard A. Schwarz, Jennifer Carns, Imran S. Vohra, Júlio C. Possati-Resende, Márcio Antoniazzi, Bruno de Oliveira Fonseca, Karen C. Borba Souza, Iara V. Vidigal Santana, Flávia Fazzio Barbin, Regis Kreitchmann, Nirmala Ramanujam, Kathleen M. Schmeler, and Rebecca R. Richards-Kortum
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- 2024
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24. Investigating Mercury's Environment with the Two-Spacecraft BepiColombo Mission
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Milillo, A., Fujimoto, M., Murakami, G., Benkhoff, J., Zender, J., Aizawa, S., Dósa, M., Griton, L., Heyner, D., Ho, G., Imber, S. M., Jia, X., Karlsson, T., Killen, R. M., Laurenza, M., Lindsay, S. T., McKenna-Lawlor, S., Mura, A., Raines, J. M., Rothery, D. A., André, N., Baumjohann, W., Berezhnoy, A., Bourdin, P. -A., Bunce, E. J., Califano, F., Deca, J., de la Fuente, S., Dong, C., Grava, C., Fatemi, S., Henri, P., Ivanovski, S. L., Jackson, B. V., James, M., Kallio, E., Kasaba, Y., Kilpua, E., Kobayashi, M., Langlais, B., Leblanc, F., Lhotka, C., Mangano, V., Martindale, A., Massetti, S., Masters, A., Morooka, M., Narita, Y., Oliveira, J. S., Odstrcil, D., Orsini, S., Pelizzo, M. G., Plainaki, C., Plaschke, F., Sahraoui, F., Seki, K., Slavin, J. A., Vainio, R., Wurz, P., Barabash, S., Carr, C. M., Delcourt, D., Glassmeier, K. -H., Grande, M., Hirahara, M., Huovelin, J., Korablev, O., Kojima, H., Lichtenegger, H., Livi, S., Matsuoka, A., Moissl, R., Moncuquet, M., Muinonen, K., Quèmerais, E., Saito, Y., Yagitani, S., Yoshikawa, I., and Wahlund, J. -E.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The ESA-JAXA BepiColombo mission will provide simultaneous measurements from two spacecraft, offering an unprecedented opportunity to investigate magnetospheric and exospheric dynamics at Mercury as well as their interactions with the solar wind, radiation, and interplanetary dust. Many scientific instruments onboard the two spacecraft will be completely, or partially devoted to study the near-space environment of Mercury as well as the complex processes that govern it. Many issues remain unsolved even after the MESSENGER mission that ended in 2015. The specific orbits of the two spacecraft, MPO and Mio, and the comprehensive scientific payload allow a wider range of scientific questions to be addressed than those that could be achieved by the individual instruments acting alone, or by previous missions. These joint observations are of key importance because many phenomena in Mercury's environment are highly temporally and spatially variable. Examples of possible coordinated observations are described in this article, analysing the required geometrical conditions, pointing, resolutions and operation timing of different BepiColombo instruments sensors., Comment: 78 pages, 14 figures, published
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- 2022
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25. Demonstration of MHz frequency domain multiplexing readout of 37 transition edge sensors for high-resolution x-ray imaging spectrometers
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Akamatsu, H., Vaccaro, D., Gottardi, L., van der Kuur, J., de Vries, C. P., Kiviranta, M., Ravensberg, K., D'Andrea, M., Taralli, E., de Wit, M., Bruijn, M. P., van der Hulst, P., Hartog, R. H. den, van Leeuwen, B-J., van der Linden, A. J., McCalden, A. J, Nagayoshi, K., Nieuwenhuizen, A. C. T., Ridder, M. L., Visser, S., van Winden, P., Gao, J. R., Hoogeveen, R. W. M., Jackson, B. D., and Herder, J-W. A. den
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Physics - Instrumentation and Detectors ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We report on the development and demonstration of a MHz frequency domain multiplexing (FDM) technology to read out arrays of cryogenic transition edge sensor (TES) X-ray microcalorimeters. In our FDM scheme, TESs are AC-biased at different resonant frequencies in the low MHz range through an array of high-$Q$ LC resonators. The current signals of all TESs are summed at superconducting quantum interference devices (SQUIDs). We have demonstrated multiplexing for a readout of 31 pixels using room temperature electronics, high-$Q$ LC filters and TES arrays developed at SRON, and SQUID arrays from VTT. We repeated this on a second setup with 37 pixels. The summed X-ray spectral resolutions $@$ 5.9 keV are $\Delta E_{\rm 31 pix ~MUX}=2.14\pm0.03$ eV and $\Delta E_{\rm 37 pix ~MUX}=2.23\pm0.03$ eV. The demonstrated results are comparable with other multiplexing approaches. There is potential to further improve the spectral resolution and to increase the number of multiplexed TESs, and to open up applications for TES X-ray microcalorimeters., Comment: 6 pages, 3 figures, accepted for publication on Applied physics letters
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- 2021
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26. Clinical beak and feather disease virus infection in wild juvenile eastern rosellas of New Zealand ; biosecurity implications for wildlife care facilities
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Jackson, B.
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- 2014
27. Defining the impact of flavivirus envelope protein glycosylation site mutations on sensitivity to broadly neutralizing antibodies
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Maya Contreras, Jackson B. Stuart, Lisa M. Levoir, Laura Belmont, and Leslie Goo
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flavivirus ,broadly neutralizing antibodies ,envelope glycosylation ,Microbiology ,QR1-502 - Abstract
ABSTRACT Antibodies targeting an envelope dimer epitope (EDE) cross-neutralize Zika virus (ZIKV) and dengue virus (DENV) and have thus inspired an epitope-focused vaccine design. There are two EDE antibody subclasses (EDE1, EDE2) distinguished by their dependence on viral envelope protein N-linked glycosylation at position N153 (DENV) or N154 (ZIKV) for binding. Here, we determined how envelope glycosylation site mutations affect neutralization by EDE and other broadly neutralizing antibodies. Consistent with structural studies, mutations abolishing the N153/N154 glycosylation site increased DENV and ZIKV sensitivity to neutralization by EDE1 antibodies. Surprisingly, despite their location at predicted contact sites, these mutations also increased sensitivity to EDE2 antibodies. Moreover, despite preserving the glycosylation site motif (N-X-S/T), substituting the threonine at ZIKV envelope residue 156 with a serine resulted in loss of glycan occupancy accompanied with increased neutralization sensitivity to EDE antibodies. For DENV, the presence of a serine instead of a threonine at envelope residue 155 retained glycan occupancy, but nonetheless increased sensitivity to EDE antibodies, in some cases to a similar extent as mutation at N153, which abolishes glycosylation. Envelope glycosylation site mutations also increased ZIKV and DENV sensitivity to other non-EDE broadly neutralizing antibodies, but had limited effects on ZIKV- or DENV-specific antibodies. Thus, envelope protein glycosylation is context-dependent and modulates the potency of broadly neutralizing antibodies in a manner not predicted by existing structures. Manipulating envelope protein glycosylation could be a novel strategy for engineering vaccine antigens to elicit antibodies that broadly neutralize ZIKV and DENV.IMPORTANCEAntibodies that potently cross-neutralize Zika (ZIKV) and dengue (DENV) viruses are attractive to induce via vaccination to protect against these co-circulating flaviviruses. Structural studies have shown that viral envelope protein glycosylation is important for binding by one class of these so-called broadly neutralizing antibodies, but less is known about its effect on neutralization. Here, we investigated how envelope protein glycosylation site mutations impact the potency of broadly neutralizing antibodies against ZIKV and DENV. We found that glycan occupancy was not always predicted by an intact N-X-S/T sequence motif. Moreover, envelope protein glycosylation site mutations alter the potency of broadly neutralizing antibodies in a manner unexpected from their predicted binding mechanism as determined by existing structures. We therefore highlight the complex role and determinants of envelope protein glycosylation that should be considered in the design of vaccine antigens to elicit broadly neutralizing antibodies.
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- 2024
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28. Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial
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Faust, Saul N, Haynes, Richard, Jones, Christine E, Staplin, Natalie, Whittaker, Elizabeth, Jaki, Thomas, Juszczak, Ed, Spata, Enti, Wan, Mandy, Bamford, Alasdair, Dimitri, Paul, Finn, Adam, Furness, John, Ramanan, Athimalaipet V, Gale, Christopher, Cathie, Katrina, Drysdale, Simon, Bernatoniene, Jolanta, Murray, Clare, Roehr, Charles C, Fleming, Paul, Riordan, Andrew, Bandi, Srini, Jyothish, Deepthi, Evans, Jennifer, Emonts, Marieke, Kelly, Dominic, Pathan, Nazima, Davies, Patrick, Hague, Rosie, Pollock, Louisa, Semple, Malcolm G, Peto, Leon, Baillie, J Kenneth, Buch, Maya, Jeffery, Katie, Knight, Marian, Lim, Wei Shen, Montgomery, Alan, Mukherjee, Aparna, Mumford, Andrew, Rowan, Kathryn, Thwaites, Guy, Mafham, Marion, Emberson, Jonathan, Landray, Martin J, Horby, Peter W, Chappell, Lucy, Day, Jeremy, Dung, DV, Quang, NN, Binh, Prof, Burhan, E, Alisjahbana, B, Koirala, J, Basnet, S, Kestelyn, E, Basnyat, B, Gyanwali, P, Hamers, RL, Sandercock, P, Darbyshire, J, DeMets, D, Fowler, R, 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A, Waidyanatha, S, Waite, A, Wake, R, Wakefield, A, Wakeford, W, Wakinshaw, F, Waldeck, E, Walden, A, Walding, L, Waldron, A, Waldron, J, Wales, E, Wali, B, Walker, D, Walker, G, Walker, H, Walker, I, Walker, K, Walker, L, Walker, O, Walker, R, Wallace, G, Wallbutton, R, Wallen, J, Waller, A, Waller, R, Wallis, G, Wallis, L, Wallis, M, Walmsley, E, Walsh, D, Walsh, E, Walsh, L, Walstow, D, Walter, D, Walters, A, Walters, H, Walton, L, Walton, M, Walton, O, Walton, S, Wands, M, Wane, R, Wang, F, Wang, N, Wang, R, Wang, S, Warbrick, D, Warburton, S, Ward, C, Ward, D, Ward, E, Ward, H, Ward, J, Ward, L, Ward, N, Ward, R, Ward, T, Warden, S, Wardere, G, Wardle, S, Wardy, H, Waring, G, Waring, S, Warner, B, Warner, C, Warnock, L, Warran, S, Warren, J, Warren, L, Warren, R, Warren, Y, Warrender, D, Warren-Miell, H, Warwick, G, Wassall, H, Wasson, E, Wastson, E, Watchorn, H, Waterfall, H, Waters, A, Waters, D, Waterstone, M, Watkin, A, Watkins, C, Watkins, E, Watkins, K, Watkins, L, Watson, A, Watson, E, Watson, F, Watson, J, Watson, K, Watson, L, Watson, P, Watson, R, Watters, M, Watterson, D, Watts, D, Watts, J, Watts, M, Waugh, V, Wayman, M, Wazir, A, Weatherhead, M, Weatherly, N, Webb, C, Webb, H, Webb, K, Webb, S, Websdale, C, Webster, D, Webster, I, Webster, J, Webster, T, Wedlin, J, Wee, L, Weerakoon, R, Weerasinghe, T, Weeratunga, J, Weetman, M, Wei, S, Weichert, I, Welch, E, Welch, H, Welch, L, Welch, S, Welham, B, Weller, S, Wellings, L, Wells, B, Wellstead, S, Welsh, B, Welters, I, Welton, R, Wenn, V, Wentworth, L, Wesonga, J, Wesseldine, K, West, J, West, M, West, R, West, S, Western, L, Westhead, R, Weston, H, Westwood, A, Westwood, K, Westwood, S, Wetherill, B, Wheaver, S, Wheeler, H, Whelan, B, Whelband, M, Whileman, A, Whitcher, A, White, A, White, B, White, C, White, D, White, J, White, K, White, M, White, N, White, S, White, T, Whitehead, C, Whitehorn, K, Whitehouse, C, Whitehouse, T, Whiteley, J, Whiteley, L, Whiteley, S, Whitham, R, Whitlingum, G, Whitmore, D, Whittam, L, Whittington, A, Whittle, H, Whittle, R, Wiafe, E, Wiblin, L, Wickens, O, Widdrington, J, Wieboldt, J, Wieringa, H, Wiesender, C, Wiffen, L, Wight, A, Wignall, A, Wignall, C, Wilce, A, Wilcock, D, Wilcock, E, Wilcox, L, Wild, B, Wild, L, Wild, S, Wilde, M, Wilding, L, Wilding, P, Wildsmith, T, Wileman, J, Wiles, K, Wilhelmsen, E, Wiliams, T, Wilkie, J, Wilkin, D, Wilkins, H, Wilkins, J, Wilkins, S, Wilkinson, I, Wilkinson, L, Wilkinson, N, Wilkinson, T, Willetts, S, Williams, A, Williams, C, Williams, D, Williams, E, Williams, G, Williams, H, Williams, J, Williams, K, Williams, M, Williams, R, Williams, S, Williams, T, Williamson, A, Williamson, H, Williamson, R, Willis, E, Willis, H, Willis, J, Wills, L, Willsher, L, Willshire, C, Wilson, A, Wilson, B, Wilson, D, Willson, F, Wilson, I, Willson, J, Wilson, K-A, Wilson, L, Wilson, M, Wilson, T, Win, K, Win, M, Win, T, Win, W, Winckworth, L, Winder, L, Winder, P, Winearl, S, Winmill, H, Winn, S, Winpenny, C, Winslow, H, Winter, H, Winter, J, Winter-Goodwin, B, Winterton, J, Winwood, H, Wischhusen, J, Wisdom, S, Wise, M, Wiselka, M, Wiseman, R, Wiseman, S, Wishart, S, Wishlade, T, Witele, E, Withers, N, Wixted, D, Wodehouse, T, Wolf, W, Wolff, N, Wolffsohn, K, Wolf-Roberts, R, Wolodimeroff, E, Wolstencroft, A, Wong, A, Wong, C, Wong, C H, Wong, E, Wong, J, Wong, K, Wong, M, Wong, N, Wong, S, Wong, T, Wood, A, Wood, D, Wood, F, Wood, G, Wood, H, Wood, J, Wood, L, Wood, M, Wood, S, Wood, T, Woodall, K, Woodfield, R, Woodford, C, Woodford, E, Woodford, J, Woodhead, L, Woodhead, T, Woodland, P, Woodman, M, Woodmansey, S, Woods, C, Woods, J, Woods, K, Woods, S, Woodward, Z, Woolcock, M, Wooldridge, G, Woolf, R, Woollard, C, Woollen, L, Woolley, E, Woolley, J, Woosey, D, Wootton, D, Wootton, J, Worley, D, Worton, S, Wraight, J, Wray, M, Wren, K, Wren, L, Wrey Brown, C, Wright, C, Wright, D, Wright, F, Wright, H, Wright, I, Wright, L, Wright, R, Wright, S, Wright, T, Wroe, C, Wroe, H, Wu, H, Wu, P, Wubetu, J, Wulandari, R, Wurie, S, Wyatt, C, Wyn-Griffiths, F, Wynter, I, Xavier, B, Xhikola, A, Xia, B, Xia, Z, Y Ellis, T, Yacoba, E, Yakubi, M, Yan, M, Yanagisawa, Y, Yang, F, Yang, Y, Yanney, M, Yap, W, Yaqoob, N, Yasmin, S, Yates, B, Yates, D, Yates, E, Yates, H, Yates, M, Yates, T, Ye, J, Yearwood Martin, C, Yein, K, Yeoh, A, Yeung, C, Yew, P, Yewatkar, D, Ylquimiche Melly, L, Ynter, I, Yong, H, Yorke, J, Youens, J, Younes Ibrahim, A, Young, E, Young, G, Young, L, Yousafzar, A, Youssouf, S, Yousuf, A, Yu, C, Yuan, J, Yung, B, Yusef, D, Yusef, S, Yusuf, I, Zafar, A-M, Zagalo, S, Zaher, S, Zahoor, A, Zainab, M, Zak, T, Zaki, K, Zakir, N, Zalewska, K, Zamalloa, A, Zaman, M, Zaman, S, Zamikula, J, Zammit, L, Zammit-Mangion, M, Zawadzka, M, Zebracki, E, Zehnder, D, Zeidan, L, Zeinali, D, Zhang, J, Zhao, X, Zheng, D, Zia, M, Zibdeh, O, Zill-E-Huma, R, Zin, E, Zincone, E, Zindoga, G, Zinkin, E, Zinyemba, V, Zipitis, C, Zitter, L, Zmierczak, A, Zubikarai, G, Zubir, A, Zuhra, N, Zulaikha, R, Zulfikar, S, Zullo, C, and Zuriaga-Alvaro, A
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- 2024
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29. Frequency Shift Algorithm: Application to a Frequency-Domain Multiplexing Readout of X-ray Transition-Edge Sensor Microcalorimeters
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Vaccaro, D., Akamatsu, H., van der Kuur, J., van der Hulst, P., Nieuwenhuizen, A. C. T., van Winden, P., Gottardi, L., Hartog, R. den, Bruijn, M. P., D'Andrea, M., Gao, J. R., Herder, J. W. A. den, Hoogeveen, R. W. M., Jackson, B., van der Linden, A. J., Nagayoshi, K., Ravensberg, K., Ridder, M. L., Taralli, E., and de Wit, M.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
In the frequency-domain multiplexing (FDM) scheme, transition-edge sensors (TES) are individually coupled to superconducting LC filters and AC biased at MHz frequencies through a common readout line. To make efficient use of the available readout bandwidth and to minimize the effect of non-linearities, the LC resonators are usually designed to be on a regular grid. The lithographic processes however pose a limit on the accuracy of the effective filter resonance frequencies. Off-resonance bias carriers could be used to suppress the impact of intermodulation distortions, which nonetheless would significantly affect the effective bias circuit and the detector spectral performance. In this paper we present a frequency shift algorithm (FSA) to allow off-resonance readout of TES's while preserving the on-resonance bias circuit and spectral performance, demonstrating its application to the FDM readout of a X-ray TES microcalorimeter array. We discuss the benefits in terms of mitigation of the impact of intermodulation distortions at the cost of increased bias voltage and the scalability of the algorithm to multi-pixel FDM readout. We show that with FSA, in multi-pixel and frequencies shifted on-grid, the line noises due to intermodulation distortion are placed away from the sensitive region in the TES response and the X-ray performance is consistent with the single-pixel, on-resonance level., Comment: Accepted for publication on Review of Scientific Instruments
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- 2021
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30. Comparative Analysis of Nonlinear Methods for Multivariable Water Level Prediction: The Case Study of the Atrato River.
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Jackson B. Renteria-Mena, Douglas Plaza, and Eduardo Giraldo 0001
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- 2024
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31. Multivariate Hydrological Modeling Based on Long Short-Term Memory Networks for Water Level Forecasting
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Jackson B. Renteria-Mena, Douglas Plaza, and Eduardo Giraldo
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data analysis ,time-series analysis ,prediction ,recurrent neural network ,flood risk assessment ,nonlinear autoregressive model ,Information technology ,T58.5-58.64 - Abstract
In the Department of Chocó, flooding poses a recurrent and significant challenge due to heavy rainfall and the dense network of rivers characterizing the region. However, the lack of adequate infrastructure to prevent and predict floods exacerbates this situation. The absence of early warning systems, the scarcity of meteorological and hydrological monitoring stations, and deficiencies in urban planning contribute to the vulnerability of communities to these phenomena. It is imperative to invest in flood prediction and prevention infrastructure, including advanced monitoring systems, the development of hydrological prediction models, and the construction of hydraulic infrastructure, to reduce risk and protect vulnerable communities in Chocó. Additionally, raising public awareness of the associated risks and encouraging the adoption of mitigation and preparedness measures throughout the population are essential. This study introduces a novel approach for the multivariate prediction of hydrological variables, specifically focusing on water level forecasts for two hydrological stations along the Atrato River in Colombia. The model, utilizing a specialized type of recurrent neural network (RNN) called the long short-term memory (LSTM) network, integrates data from hydrological variables, such as the flow, precipitation, and level. With a model architecture featuring four inputs and two outputs, where flow and precipitation serve as inputs and the level serves as the output for each station, the LSTM model is adept at capturing the complex dynamics and cross-correlations among these variables. Validation involves comparing the LSTM model’s performance with linear and nonlinear Autoregressive with Exogenous Input (NARX) models, considering factors such as the estimation error and computational time. Furthermore, this study explores different scenarios for water level prediction, aiming to utilize the proposed approach as an effective flood early warning system.
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- 2024
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32. Regularity of detonation cellular structures in hydrocarbon mixtures of moderate effective activation energies
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Genter, Ethan S., Kennedy, Jackson B., Sipper, Cinnamon, Jayaraman, Amitesh S., Montes, Nicholas, and Wang, Hai
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- 2024
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33. Progress in the development of frequency domain multiplexing for the X-ray Integral Field Unit on board the Athena mission
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Akamatsu, H., Gottardi, L., van der Kuur, J., de Vries, C. P., Bruijn, M. P., Chervenak, J. A., Kiviranta, M., Linden, A. J. van den, Jackson, B. D., Miniussi, A., Ravensberg, K., Sakai, K., Smith, S. J., and Wakeham, N.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Frequency domain multiplexing (FDM) is the baseline readout system for the X-ray Integral Field Unit (X-IFU) on board the Athena mission. Under the FDM scheme, TESs are coupled to a passive LC filter and biased with alternating current (AC bias) at MHz frequencies. Using high-quality factor LC filters and room temperature electronics developed at SRON and low-noise two-stage SQUID amplifiers provided by VTT, we have recently demonstrated good performance with the FDM readout of Mo/Au TES calorimeters with Au/Bi absorbers. We have achieved a performance requested for the demonstration model (DM) with the single pixel AC bias ($\Delta E=$1.8 eV) and 9 pixel multiplexing ($\Delta E=$2.6 eV) modes. We have also demonstrated 14-pixel multiplexing with an average energy resolution of 3.3 eV, which is limited by non-fundamental issues related to FDM readout in our lab setup., Comment: 7 pages, 5 figures. Published on Journal of Low Temperature Physics (2020)
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- 2020
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34. Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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Abani, O, Abbas, A, Abbas, F, Abbas, J, Abbas, K, Abbas, M, Abbasi, S, Abbass, H, Abbott, A, Abdallah, N, Abdelaziz, A, Abdelfattah, M, Abdelqader, B, Abdul, A, Abdul, B, Abdul, S, Abdul Rasheed, A, Abdulakeem, A, Abdul-Kadir, R, Abdullah, A, Abdulmumeen, A, Abdul-Raheem, R, Abdulshukkoor, N, Abdusamad, K, Abed El Khaleq, Y, Abedalla, M, Abeer Ul Amna, A, Abel, L, Abernethy, K, Abeywickrema, M, Abhinaya, C, Abidin, A, Aboaba, A, Aboagye-Odei, A, Aboah, C, Aboelela, H, Abo-Leyah, H, Abouelela, K, Abou-Haggar, A, Abouibrahim, M, Abousamra, A, Abouzaid, M, Abraham, M, Abraham, T, Abraheem, A, Abrams, J, Abrams, R, Abu, HJ, Abu-Arafeh, A, Abubacker, SM, Abung, A, Abusamra, Y, Aceampong, Y, Achara, A, Acharya, D, Acheampong, F, Acheampong, P, Acheampong, S, Acheson, J, Achieng, S, Acosta, A, Acquah, R, Acton, C, Adabie-Ankrah, J, Adair, P, Adam, AS, Adam, F, Adam, M, Adamali, H, Adamczyk, M, Adams, C, Adams, D, Adams, K, Adams, L, Adams, N, Adams, R, Adams, T, Adamu-Ikeme, L, Adatia, K, Adcock, K, Addai-Boampong, L, Addo, A, Adeagbo, O, Adebiyi, A, Adedeji, O, Adegeye, Y, Adegoke, K, Adell, V, Adenwalla, S, Adeoye, FW, Adesemoye, OA, Adewunmi, EO, Adeyanju, A, Adeyemi, J, Adeyemo, T, Adhikari, B, Adhikari, SA, Adhikary, R, Aditya, A, Adjepong, P, Adkins, G, Adnan, A, Adriaanse, M, Aeron-Thomas, J, Affleck, D, Afnan, C, Afridi, M, Afrim, P, Afriyie, FA, Aftab, ZA, Afum-Adjei Awuah, A, Agarwal, M, Agasiya, PN, Agbeko, R, Agbo, C, Aggarwal, S, Aghababaie, A, Aguilar Jimenez, L, Agyekum, JA, Agyen, K, Ahadome, EK, Ahamed Sadiq, S, Ahammed Nazeer, MH, Ahmad, M, Ahmad, S, Ahmed, A, Ahmed, BAR, Ahmed, B, Ahmed, F, Ahmed, H, Ahmed, I, Ahmed, K, Ahmed, L, Ahmed, M, Ahmed, MC, Ahmed, MS, Ahmed, N, Ahmed, O, Ahmed, RA, Ahmed, R, Ahmed, S, Ahmed, SG, Ahmed, SH, Ahmed Ali, R, Ahmed Mohamud, B, Ahmer, S, Ahonia, A, Aidoo, C, Aiken, C, Ail, D, Ainsworth, M, Aissa, M, Aitken, L, Ajay, B, Ajibode, A, Ajmi, A, Akhtar, N, Akili, S, Akinbiyi, B, Akindolie, O, Akinfenwa, Y, Akinkugbe, O, Akinpelu, I, Akram, M, Aktinade, O, Akudi, U, Al Aaraj, ASAR, Al Balushi, A, Al Dakhola, M, Al Swaifi, A, Al-Abadi, E, Alabi, A, Aladangady, N, Alafifi, M, Alam, A, Alam, S, Al-Asadi, A, Alatzoglou, K, Albert, P, Albertus, A, Albon, L, Alcala, A, Alcorn, G, Alcorn, S, Aldana, A, Alderdice, D, Aldesouki, A, Aldouri, R, Aldridge, J, Aldridge, N, Ale, RM, Alegria, A, Alexander, A, Alexander, C, Alexander, J, Alexander, PDG, Al-fori, J, Alghazawi, L, Alhabsha, O, Al-Hakim, B, Alhameed, R, Al-Hayali, M, Al-Hity, S, Ali, A, Ali, FR, Ali, J, Ali, M, Ali, MS, Ali, N, Ali, O, Ali, R, Ali, S, Aliberti, E, Alin, J, Alina, A, Alipustain, A, Alisjahbana, B, Aliyuda, F, Alizadeh, K, Al-Jibury, M, Al-Juboori, S, Al-Khalil, M, Alkhudhayri, A, Alkhusheh, M, Allan, F, Allan, N, Allanson, A, Allcock, R, Allen, E, Allen, J, Allen, K, Allen, L, Allen, P, Allen, R, Allen, S, Allen, T, Alli, A, Allison, K, Allman, B, Allsop, HK, Allsop, L, Allsup, D, Almahroos, AFT, Al-Moasseb, H, Al-Obaidi, M, Alomari, L, 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Vancheeswaran, R, Vandeyoon, SI, Vankayalapati, P, Vanmali, P, Vansomeren, C, Van't Hoff, W, Vanya, KN, Vara, S, Vardy, SJ, Varghese, A, Varghese, M, Varney, W, Varnier, G, Varouxaki, A-N, Varquez, R, Vasadi, V, Vass, O, Vassell, K, Vasu, V, Vasudevan, V, Vatish, M, Vaughan, S, Vayalaman, H, Vayapooree, D, Vaz, C, Veale, N, Veerasamy, S, Velankar, S, Velauthar, L, Veli, N, Vella, N, Velugupati, A, Velusamy, A, Venables, I, Venditti, M, Venkataramakrishnan, R, Venn, R, Venter, M, Ventilacion, L, Vere, J, Veres, M, Vergnano, S, Verling, W, Verma, A, Vernall, R, Vernon, B, Vertue, M, Verueco, L, Verula, J, Veterini, A, Vethanayagam, N, Vettikumaran, S, Veys, L, Vickers, C, Victor, S, Victoria, S, Vidaillac, CP, Vidler, J, Vijayakumar, B, Vijayaraghavan Nalini, VW, Vilcinskaite, B, Vileito, A, Vilimiene, N, Vinall, L, Vinay, S, Vinayakarao, L, Vincent, O, Vincent, R, Virdee, P, Virgilio, E, Virk, AM, Visentin, E, Vitaglione, M, Vithian, K, Vittoria, S, Vivekananthan, S, Vlad, E, Vlies, B, von Oven, L, Vooght, C, Vu Thai, KT, Vutipongsatorn, K, Vuylsteke, A, Vyras, E, Wach, R, Wadams, B, Wadd, S, Waddington, N, Wade, P, Wadsley, J, Wadsworth, K, Wafa, SEI, Wagstaff, D, Wagstaff, L, Wahab, D, Wahbi, Z, Waheed Adigun, A, Waidyanatha, S, Waite, A, Wake, R, Wakefield, A, Wakeford, W, Wakinshaw, F, Waldeck, E, Walden, A, Walding, L, Waldron, A, Waldron, J, Wales, E, Wali, B, Walker, D, Walker, G, Walker, H, Walker, I, Walker, K, Walker, L, Walker, O, Walker, R, Walker, S, Wallace, G, Wallbutton, R, Wallen, J, Wallendszus, K, Waller, A, Waller, R, Wallis, G, Wallis, L, Wallis, M, Walmsley, E, Walsh, D, Walsh, E, Walsh, L, Walstow, D, Walter, D, Walters, A, Walters, H, Walters, J, Walton, E, Walton, L, Walton, M, Walton, O, Walton, S, Wan, M, Wanda, J, Wands, M, Wane, R, Wang, F, Wang, N, Wang, R, Wang, S, Warbrick, D, Warburton, S, Ward, C, Ward, D, Ward, E, Ward, H, Ward, J, Ward, L, Ward, N, Ward, R, Ward, T, Warden, SA, Wardere, G, Wardle, S, Wardy, H, Waring, G, Waring, S, Warmington, J, Warner, B, Warner, C, Warnock, L, Warran, S, Warren, J, Warren, L, Warren, R, Warren, Y, Warrender, D, Warren-Miell, H, Warris, A, Warwick, G, Wassall, H, Wasserman, S, Wasson, E, Watchorn, HJ, Waterfall, H, Waters, A, Waters, D, Waterstone, M, Watkin, A, Watkins, C, Watkins, E, Watkins, K, Watkins, L, Watson, A, Watson, AJR, Watson, E, Watson, F, Watson, JGR, Watson, L, Watson, P, Watson, R, Watson, K, Watters, M, Watterson, D, Wattimena, K, Watts, D, Watts, J, Watts, M, Waugh, V, Wayman, E, Wayman, M, Wazir, A, Weatherhead, M, Weatherly, N, Webb, C, Webb, H, Webb, K, Webb, S, Websdale, C, Webster, D, Webster, I, Webster, J, Webster, T, Wedlin, J, Wee, L, Weerakoon, R, Weerasinghe, T, Weeratunga, J, Weetman, M, Wei, S, Weichert, I, Welch, E, Welch, H, Welch, J, Welch, L, Welch, S, Welham, B, Weller, S, Wellings, L, Wells, B, Wellstead, S, Welsh, B, Welsh, R, Welters, I, Welton, R, Wenn, V, Wentworth, L, Wesonga, J, Wesseldine, K, West, J, West, M, West, R, West, S, Western, L, Westhead, R, Weston, H, Westwood, A, Westwood, K, Westwood, S, Wetherill, B, Wheaver, S, Wheeler, H, Whelan, B, Whelband, M, Whileman, A, Whitcher, A, White, A, White, B, White, C, White, D, White, J, White, K, White, M, White, N, White, S, White, T, Whitehead, C, Whitehorn, K, Whitehouse, A, Whitehouse, C, Whitehouse, T, Whiteley, J, Whiteley, L, Whiteley, S, Whitham, R, Whitlingum, G, Whitmore, D, Whittaker, E, Whittam, L, Whittington, A, Whittle, H, Whittle, R, Wiafe, E, Wiblin, L, Wickens, O, Widdrington, J, Wieboldt, J, Wieringa, H, Wiesender, C, Wiffen, L, Wight, A, Wignall, A, Wignall, C, Wilce, A, Wilcock, D, Wilcock, E, Wilcox, L, Wild, B, Wild, L, Wild, S, Wilde, M, Wilding, L, Wilding, P, Wildsmith, T, Wileman, J, Wiles, J, Wiles, K, Wilhelmsen, E, Wiliams, T, Wilkie, J, Wilkin, D, Wilkins, H, Wilkins, J, Wilkins, S, Wilkinson, I, Wilkinson, L, Wilkinson, N, Wilkinson, S, Wilkinson, T, Willetts, S, Williams, A, Williams, C, Williams, CV, Williams, D, Williams, E, Williams, G, Williams, H, Williams, J, Williams, K, Williams, M, Williams, P, Williams, R, Williams, S, Williams, T, Williamson, A, Williamson, C, Williamson, D, Williamson, J, Williamson, JD, Williamson, R, Williamson, H, Willis, E, Willis, H, Willis, J, Wills, L, Willsher, L, Willshire, C, Willson, F, Willson, J, Wilson, A, Wilson, B, Wilson, D, Wilson, I, Wilson, J, Wilson, K, Wilson, K-A, Wilson, L, Wilson, M, Wilson, S, Wilson, T, Win, KLY, Win, M, Win, T, Win, TT, Win, WYW, Winckworth, L, Winder, L, Winder, P, Winearl, S, Winmill, H, Winn, S, Winpenny, C, Winslow, H, Winter, H, Winter, J, Winter-Goodwin, B, Winterton, J, Winwood, H, Wischhusen, J, Wisdom, S, Wise, M, Wiselka, M, Wiseman, R, Wiseman, S, Wishart, S, WIshlade, T, Witele, E, Withers, N, Wittes, J, Wixted, D, Wodehouse, T, Wolf, W, Wolff, N, Wolffsohn, K, Wolf-Roberts, R, Wolodimeroff, E, Wolstencroft, A, Wong, A, Wong, C, Wong, C-H, Wong, C-M, Wong, E, Wong, JSY, Wong, KY, Wong, MY, Wong, N, Wong, S, Wong, T, Wongkyezeng, AA, Wood, A, Wood, C, Wood, D, Wood, F, Wood, G, Wood, H, Wood, J, Wood, L, Wood, M, Wood, S, Wood, T, Woodall, K, Woodfield, R, Woodford, C, Woodford, E, Woodford, J, Woodhead, L, Woodhead, T, Woodland, P, Woodman, M, Woodmansey, S, Woods, C, Woods, J, Woods, K, Woods, S, Woodward, Z, Woolcock, M, Wooldridge, G, Woolf, R, Woollard, C, Woollen, L, Woolley, E, Woolley, J, Woosey, D, Wootton, D, Wootton, J, Worley, D, Worton, S, Wraight, J, Wray, M, Wren, K, Wren, L, Wrey Brown, C, Wright, C, Wright, D, Wright, F, Wright, H, Wright, I, Wright, L, Wright, R, Wright, S, Wright, T, Wroe, C, Wroe, H, Wu, H, Wu, P, Wubetu, J, Wulandari, F, Wulandari, R, Wurie, S, Wyatt, C, Wyn-Griffiths, F, Wynter, I, Xavier, B, Xhikola, A, Xia, BE, Xia, Z, Yacoba, E, Yadav, S, Yakubi, M, Yan, M, Yanagisawa, Y, Yang, F, Yang, Y, Yanney, M, Yap, WL, Yaqoob, N, Yasmin, S, Yates, B, Yates, D, Yates, E, Yates, H, Yates, T, Yates, M, Ye, J, Yearwood Martin, C, Yein, K, Yelnoorkar, F, Yen, LM, Yeoh, A, Yeung, CY, Yew, P, Yewatkar, D, Ylquimiche Melly, L, Ynter, I, Yong, H, Yorke, J, Youens, J, Younes Ibrahim, A, Young, E, Young, G, Young, L, Yousafzar, A, Youssouf, S, Yousuf, A, Yovita, H, Yu, C, Yuan, JSJ, Yufaniaputri, N, Yung, B, Yusef, D, Yusef, S, Yusuf, I, Zafar, A-S, Zagalo, S, Zaher, S, Zahoor, A, Zainab, M, Zak, T, Zaki, K, Zakir, N, Zalewska, K, Zamalloa, A, Zaman, M, Zaman, S, Zamikula, J, Zammit, L, Zammit-Mangion, M, Zawadzka, M, Zayed, M, Zebracki, E, Zehnder, D, Zeidan, L, Zeinali, D, Zhang, J, Zhao, X, Zheng, D, Zhu, D, Zia, M, Zibdeh, O, Zill-E-Huma, R, Zin, ET, Zincone, E, Zindoga, G, Zinkin, E, Zinyemba, V, Zipitis, C, Zitter, L, Zmierczak, A, Zubikarai, G, Zubir, A, Zuhra, N, Zulaikha, R, Zulfikar, S, Zullo, C, and Zuriaga-Alvaro, A
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- 2023
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35. Two Sides of a Coin: a Zika Virus Mutation Selected in Pregnant Rhesus Macaques Promotes Fetal Infection in Mice but at a Cost of Reduced Fitness in Nonpregnant Macaques and Diminished Transmissibility by Vectors
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Lemos, Danilo, Stuart, Jackson B, Louie, William, Singapuri, Anil, Ramírez, Ana L, Watanabe, Jennifer, Usachenko, Jodie, Keesler, Rebekah I, Martin, Claudia Sanchez-San, Li, Tony, Martyn, Calla, Oliveira, Glenn, Saraf, Sharada, Grubaugh, Nathan D, Andersen, Kristian G, Thissen, James, Allen, Jonathan, Borucki, Monica, Tsetsarkin, Konstantin A, Pletnev, Alexander G, Chiu, Charles Y, Van Rompay, Koen KA, and Coffey, Lark L
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Reproductive Medicine ,Medical Microbiology ,Biomedical and Clinical Sciences ,Biodefense ,Emerging Infectious Diseases ,Pregnancy ,Prevention ,Genetics ,Rare Diseases ,Pediatric ,Women's Health ,Infectious Diseases ,Perinatal Period - Conditions Originating in Perinatal Period ,Vector-Borne Diseases ,2.2 Factors relating to the physical environment ,Infection ,Good Health and Well Being ,Aedes ,Animals ,Chlorocebus aethiops ,Disease Outbreaks ,Female ,Humans ,Macaca mulatta ,Male ,Mice ,Mice ,Inbred C57BL ,Mosquito Vectors ,Mutation ,Pregnancy Complications ,Infectious ,Vero Cells ,Viral Nonstructural Proteins ,Viremia ,Zika Virus ,Zika Virus Infection ,Zika virus ,arbovirus ,congenital Zika syndrome ,emergence ,experimental infection ,fitness ,flavivirus ,mouse ,mutation ,nonhuman primate ,Biological Sciences ,Agricultural and Veterinary Sciences ,Medical and Health Sciences ,Virology ,Agricultural ,veterinary and food sciences ,Biological sciences ,Biomedical and clinical sciences - Abstract
Although fetal death is now understood to be a severe outcome of congenital Zika syndrome, the role of viral genetics is still unclear. We sequenced Zika virus (ZIKV) from a rhesus macaque fetus that died after inoculation and identified a single intrahost substitution, M1404I, in the ZIKV polyprotein, located in nonstructural protein 2B (NS2B). Targeted sequencing flanking position 1404 in 9 additional macaque mothers and their fetuses identified M1404I at a subconsensus frequency in the majority (5 of 9, 56%) of animals and some of their fetuses. Despite its repeated presence in pregnant macaques, M1404I has occurred rarely in humans since 2015. Since the primary ZIKV transmission cycle is human-mosquito-human, mutations in one host must be retained in the alternate host to be perpetuated. We hypothesized that ZIKV I1404 increases viral fitness in nonpregnant macaques and pregnant mice but is less efficiently transmitted by vectors, explaining its low frequency in humans during outbreaks. By examining competitive fitness relative to that of ZIKV M1404, we observed that ZIKV I1404 produced lower viremias in nonpregnant macaques and was a weaker competitor in tissues. In pregnant wild-type mice, ZIKV I1404 increased the magnitude and rate of placental infection and conferred fetal infection, in contrast to ZIKV M1404, which was not detected in fetuses. Although infection and dissemination rates were not different, Aedes aegypti mosquitoes transmitted ZIKV I1404 more poorly than ZIKV M1404. Our data highlight the complexity of arbovirus mutation-fitness dynamics and suggest that intrahost ZIKV mutations capable of augmenting fitness in pregnant vertebrates may not necessarily spread efficiently via mosquitoes during epidemics.IMPORTANCE Although Zika virus infection of pregnant women can result in congenital Zika syndrome, the factors that cause the syndrome in some but not all infected mothers are still unclear. We identified a mutation that was present in some ZIKV genomes in experimentally inoculated pregnant rhesus macaques and their fetuses. Although we did not find an association between the presence of the mutation and fetal death, we performed additional studies with ZIKV with the mutation in nonpregnant macaques, pregnant mice, and mosquitoes. We observed that the mutation increased the ability of the virus to infect mouse fetuses but decreased its capacity to produce high levels of virus in the blood of nonpregnant macaques and to be transmitted by mosquitoes. This study shows that mutations in mosquito-borne viruses like ZIKV that increase fitness in pregnant vertebrates may not spread in outbreaks when they compromise transmission via mosquitoes and fitness in nonpregnant hosts.
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- 2020
36. Susceptibility Study of TES Micro-calorimeters for X-ray Spectroscopy Under FDM Readout
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Vaccaro, D., Akamatsu, H., Gottardi, L., van der Kuur, J., Taralli, E., de Wit, M., Bruijn, M. P., den Hartog, R., Kiviranta, M., van der Linden, A. J., Nagayoshi, K., Ravensberg, K., Ridder, M. L., Visser, S., Jackson, B. D., Gao, J. R., Hoogeveen, R. W. M., and den Herder, J. W. A.
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- 2022
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37. ATHENA X-IFU Demonstration Model: First Joint Operation of the Main TES Array and its Cryogenic AntiCoincidence Detector (CryoAC)
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D’Andrea, M., Ravensberg, K., Argan, A., Brienza, D., Lotti, S., Macculi, C., Minervini, G., Piro, L., Torrioli, G., Chiarello, F., Ferrari Barusso, L., Biasotti, M., Gallucci, G., Gatti, F., Rigano, M., Akamatsu, H., Dercksen, J., Gottardi, L., de Groote, F., den Hartog, R., den Herder, J.-W., Hoogeveen, R., Jackson, B., McCalden, A., Rosman, S., Taralli, E., Vaccaro, D., de Wit, M., Chervenak, J., Smith, S., and Wakeham, N.
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- 2022
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38. Closing the Water Balance with a Precision Small-Scale Field Lysimeter
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Brad F. Lyles, Brad D. Sion, David Page, Jackson B. Crews, Eric V. McDonald, and Mark B. Hausner
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lysimeter ,soil ,vadose zone ,evaporation ,water balance ,Chemical technology ,TP1-1185 - Abstract
We developed a set of two precision, small-scale, water balance lysimeters to provide accurate measurements of bare soil evaporation. Each lysimeter comprises a soil tank, a balance assembly with load cell, a wicking drainage system, and a stilling well to measure drained water. Fiberglass wicks installed at the bottom of the soil tanks provide −60 cm of tension to the base of the soil column, and soil water drainage is quantified to close the water balance within the lysimeter. The calibrated lysimeters return mass changes with uncertainties ranging from 3 to 8 g, corresponding to uncertainties of 0.02–0.05 mm of water. Installed at a semi-arid site in northern Nevada, the two lysimeters are filled with uniform construction sand and silt loam. Over a six-month pilot observation period, bare soil evaporation rates of 0.19 and 0.40 mm/day were measured for the construction sand and silt loam, respectively, which is consistent with meteorological data and models of potential evapotranspiration at the site. The design of the lysimeter can be adapted to specific research goals or site restrictions, and these instruments can contribute significantly to our ability to close the soil water balance.
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- 2024
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39. Validation of the Alfv\'{e}n Wave Solar atmosphere Model (AWSoM) with Observations from the Low Corona to 1 AU
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Sachdeva, N., van der Holst, B., Manchester, W. B., Tóth, G., Chen, Y., Lloveras, D. G., Vásquez, A. M., Lamy, Philippe, Wojak, Julien, Jackson, B. V., Yu, H. -S., and Henney, C. J.
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Astrophysics - Solar and Stellar Astrophysics ,Physics - Space Physics - Abstract
We perform a validation study of the latest version of the Alfv\'{e}n Wave Solar atmosphere Model (AWSoM) within the Space Weather Modeling Framework (SWMF). To do so, we compare the simulation results of the model with a comprehensive suite of observations for Carrington rotations representative of the solar minimum conditions extending from the solar corona to the heliosphere up to the Earth. In the low corona ($r < 1.25$ \Rs), we compare with EUV images from both STEREO-A/EUVI and SDO/AIA and to three-dimensional (3-D) tomographic reconstructions of the electron temperature and density based on these same data. We also compare the model to tomographic reconstructions of the electron density from SOHO/LASCO observations ($2.55 < r < 6.0$\Rs). In the heliosphere, we compare model predictions of solar wind speed with velocity reconstructions from InterPlanetary Scintillation (IPS) observations. For comparison with observations near the Earth, we use OMNI data. Our results show that the improved AWSoM model performs well in quantitative agreement with the observations between the inner corona and 1 AU. The model now reproduces the fast solar wind speed in the polar regions. Near the Earth, our model shows good agreement with observations of solar wind velocity, proton temperature and density. AWSoM offers an extensive application to study the solar corona and larger heliosphere in concert with current and future solar missions as well as being well suited for space weather predictions.
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- 2019
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40. Proximity-dependent recruitment of Polycomb repressive complexes by the lncRNA Airn
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Braceros, Aki K., Schertzer, Megan D., Omer, Arina, Trotman, Jackson B., Davis, Eric S., Dowen, Jill M., Phanstiel, Douglas H., Aiden, Erez Lieberman, and Calabrese, J. Mauro
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- 2023
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41. Movement of St. Louis encephalitis virus in the Western United States, 2014- 2018.
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Swetnam, Daniele M, Stuart, Jackson B, Young, Katherine, Maharaj, Payal D, Fang, Ying, Garcia, Sandra, Barker, Christopher M, Smith, Kirk, Godsey, Marvin S, Savage, Harry M, Barton, Vonnita, Bolling, Bethany G, Duggal, Nisha, Brault, Aaron C, and Coffey, Lark L
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Animals ,Humans ,Culicidae ,Encephalitis Virus ,St. Louis ,Encephalitis ,St. Louis ,Bayes Theorem ,Disease Outbreaks ,Phylogeny ,Genome ,Viral ,United States ,Phylogeography ,Mosquito Vectors ,Whole Genome Sequencing ,Encephalitis Virus ,St. Louis ,Encephalitis ,Genome ,Viral ,Tropical Medicine ,Biological Sciences ,Medical and Health Sciences - Abstract
St. Louis encephalitis virus (SLEV) is a flavivirus that circulates in an enzootic cycle between birds and mosquitoes and can also infect humans to cause febrile disease and sometimes encephalitis. Although SLEV is endemic to the United States, no activity was detected in California during the years 2004 through 2014, despite continuous surveillance in mosquitoes and sentinel chickens. In 2015, SLEV-positive mosquito pools were detected in Maricopa County, Arizona, concurrent with an outbreak of human SLEV disease. SLEV-positive mosquito pools were also detected in southeastern California and Nevada in summer 2015. From 2016 to 2018, SLEV was detected in mosquito pools throughout southern and central California, Oregon, Idaho, and Texas. To understand genetic relatedness and geographic dispersal of SLEV in the western United States since 2015, we sequenced four historical genomes (3 from California and 1 from Louisiana) and 26 contemporary SLEV genomes from mosquito pools from locations across the western US. Bayesian phylogeographic approaches were then applied to map the recent spread of SLEV. Three routes of SLEV dispersal in the western United States were identified: Arizona to southern California, Arizona to Central California, and Arizona to all locations east of the Sierra Nevada mountains. Given the topography of the Western United States, these routes may have been limited by mountain ranges that influence the movement of avian reservoirs and mosquito vectors, which probably represents the primary mechanism of SLEV dispersal. Our analysis detected repeated SLEV introductions from Arizona into southern California and limited evidence of year-to-year persistence of genomes of the same ancestry. By contrast, genetic tracing suggests that all SLEV activity since 2015 in central California is the result of a single persistent SLEV introduction. The identification of natural barriers that influence SLEV dispersal enhances our understanding of arbovirus ecology in the western United States and may also support regional public health agencies in implementing more targeted vector mitigation efforts to protect their communities more effectively.
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- 2020
42. A combination of two human monoclonal antibodies limits fetal damage by Zika virus in macaques
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Van Rompay, Koen KA, Coffey, Lark L, Kapoor, Tania, Gazumyan, Anna, Keesler, Rebekah I, Jurado, Andrea, Peace, Avery, Agudelo, Marianna, Watanabe, Jennifer, Usachenko, Jodie, Singapuri, Anil, Immareddy, Ramya, Ardeshir, Amir, Stuart, Jackson B, Bournazos, Stylianos, Ravetch, Jeffrey V, Balderes, Paul J, Lorenz, Ivo C, Esswein, Shannon R, Keeffe, Jennifer R, Bjorkman, Pamela J, Wang, Qiao, Rice, Charles M, MacDonald, Margaret R, Nussenzweig, Michel C, and Robbiani, Davide F
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Medical Microbiology ,Reproductive Medicine ,Biomedical and Clinical Sciences ,Immunology ,HIV/AIDS ,Prevention ,Perinatal Period - Conditions Originating in Perinatal Period ,Immunization ,Biotechnology ,Vaccine Related ,Pediatric ,Reproductive health and childbirth ,Infection ,Good Health and Well Being ,Animals ,Animals ,Newborn ,Antibodies ,Monoclonal ,Antibodies ,Neutralizing ,Disease Models ,Animal ,Drug Therapy ,Combination ,Female ,Fetus ,HEK293 Cells ,Humans ,Immunoglobulin Fc Fragments ,Immunoglobulin G ,Infectious Disease Transmission ,Vertical ,Pregnancy ,Pregnancy Complications ,Infectious ,Protein Engineering ,RNA ,Viral ,Recombinant Proteins ,Zika Virus ,Zika Virus Infection ,Fc domain modifications ,Zika virus ,macaque pregnancy model ,antibody-dependent enhancement ,congenital Zika syndrome - Abstract
Human infection by Zika virus (ZIKV) during pregnancy can lead to vertical transmission and fetal aberrations, including microcephaly. Prophylactic administration of antibodies can diminish or prevent ZIKV infection in animal models, but whether passive immunization can protect nonhuman primates and their fetuses during pregnancy has not been determined. Z004 and Z021 are neutralizing monoclonal antibodies to domain III of the envelope (EDIII) of ZIKV. Together the two antibodies protect nonpregnant macaques against infection even after Fc modifications to prevent antibody-dependent enhancement (ADE) in vitro and extend their half-lives. Here we report on prophylactic coadministration of the Fc-modified antibodies to pregnant rhesus macaques challenged three times with ZIKV during first and second trimester. The two antibodies did not entirely eliminate maternal viremia but limited vertical transmission, protecting the fetus from neurologic damage. Thus, maternal passive immunization with two antibodies to EDIII can shield primate fetuses from the harmful effects of ZIKV.
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- 2020
43. Comparing three spatial modeling tools for assessing urban ecosystem services
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Veerkamp, C.J., Loreti, M., Benavidez, R., Jackson, B, and Schipper, A.M.
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- 2023
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44. Safety and efficacy of tenecteplase in patients with wake-up stroke assessed by non-contrast CT (TWIST): a multicentre, open-label, randomised controlled trial
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Parson, M, Valente, M, Chen, A, Sharobeam, A, Edwards, L, Blair, C, Christensen, L, Ægidius, K, Pihl, T, Fassel-Larsen, C, Wassvik, L, Folke, M, Rosenbaum, S, Gharehbagh, S S, Hansen, A, Preisler, N, Antsov, K, Mallene, S, Lill, M, Herodes, M, Vibo, R, Rakitin, A, Saarinen, J, Tiainen, M, Tumpula, O, Noppari, T, Raty, S, Sibolt, G, Nieminen, J, Niederhauser, J, Haritoncenko, I, Puustinen, J, Haula, T-M, Sipilä, J, Viesulaite, B, Taroza, S, Rastenyte, D, Matijosaitis, V, Vilionskis, A, Masiliunas, R, Ekkert, A, Chmeliauskas, P, Lukosaitis, V, Reichenbach, A, Moss, T T, Nilsen, H Y, Hammer-Berntzen, R, Nordby, L M, Weiby, T A, Nordengen, K, Ihle-Hansen, H, Stankiewiecz, M, Grotle, O, Nes, M, Thiemann, K, Særvold, I M, Fraas, M, Størdahl, S, Horn, J W, Hildrum, H, Myrstad, C, Tobro, H, Tunvold, J-A, Jacobsen, O, Aamodt, N, Baisa, H, Malmberg, V N, Rohweder, G, Ellekjær, H, Ildstad, F, Egstad, E, Helleberg, B H, Berg, H H, Jørgensen, J, Tronvik, E, Shirzadi, M, Solhoff, R, Van Lessen, R, Vatne, A, Forselv, K, Frøyshov, H, Fjeldstad, M S, Tangen, L, Matapour, S, Kindberg, K, Johannessen, C, Rist, M, Mathisen, I, Nyrnes, T, Haavik, A, Toverud, G, Aakvik, K, Larsson, M, Ytrehus, K, Ingebrigtsen, S, Stokmo, T, Helander, C, Larsen, I C, Solberg, T O, Seljeseth, Y M, Maini, S, Bersås, I, Mathé, J, Rooth, E, Laska, A-C, Rudberg, A-S, Esbjörnsson, M, Andler, F, Ericsson, A, Wickberg, O, Karlsson, J-E, Redfors, P, Jood, K, Buchwald, F, Mansson, K, Gråhamn, O, Sjölin, K, Lindvall, E, Cidh, Å, Tolf, A, Fasth, O, Hedström, B, Fladt, J, Dittrich, T D, Kriemler, L, Hannon, N, Amis, E, Finlay, S, Mitchell-Douglas, J, McGee, J, Davies, R, Johnson, V, Nair, A, Robinson, M, Greig, J, Halse, O, Wilding, P, Mashate, S, Chatterjee, K, Martin, M, Leason, S, Roberts, J, Dutta, D, Ward, D, Rayessa, R, Clarkson, E, Teo, J, Ho, C, Conway, S, Aissa, M, Papavasileiou, V, Fry, S, Waugh, D, Britton, J, Hassan, A, Manning, L, Khan, S, Asaipillai, A, Fornolles, C, Tate, M L, Chenna, S, Anjum, T, Karunatilake, D, Foot, J, VanPelt, L, Shetty, A, Wilkes, G, Buck, A, Jackson, B, Fleming, L, Carpenter, M, Jackson, L, Needle, A, Zahoor, T, Duraisami, T, Northcott, K, Kubie, J, Bowring, A, Keenan, S, Mackle, D, England, T, Rushton, B, Hedstrom, A, Amlani, S, Evans, R, Muddegowda, G, Remegoso, A, Ferdinand, P, Varquez, R, Davis, M, Elkin, E, Seal, R, Fawcett, M, Gradwell, C, Travers, C, Atkinson, B, Woodward, S, Giraldo, L, Byers, J, Cheripelli, B, Lee, S, Marigold, R, Smith, S, Zhang, L, Ghatala, R, Sim, C H, Ghani, U, Yates, K, Obarey, S, Willmot, M, Ahlquist, K, Bates, M, Rashed, K, Board, S, Andsberg, G, Sundayi, S, Garside, M, Macleod, M-J, Manoj, A, Hopper, O, Cederin, B, Toomsoo, T, Gross-Paju, K, Tapiola, T, Kestutis, J, Amthor, K-F, Heermann, B, Ottesen, V, Melum, T A, Kurz, M, Parsons, M, Roaldsen, Melinda B, Eltoft, Agnethe, Wilsgaard, Tom, Christensen, Hanne, Engelter, Stefan T, Indredavik, Bent, Jatužis, Dalius, Karelis, Guntis, Kõrv, Janika, Lundström, Erik, Petersson, Jesper, Putaala, Jukka, Søyland, Mary-Helen, Tveiten, Arnstein, Bivard, Andrew, Johnsen, Stein Harald, Mazya, Michael V, Werring, David J, Wu, Teddy Y, De Marchis, Gian Marco, Robinson, Thompson G, and Mathiesen, Ellisiv B
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- 2023
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45. Signal Readout for Transition-Edge Sensor X-ray Imaging Spectrometers
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Akamatsu, H., primary, Doriese, W. B., additional, Mates, J. A. B., additional, and Jackson, B. D., additional
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- 2023
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46. SPICA - a large cryogenic infrared space telescope Unveiling the obscured Universe
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Roelfsema, P. R., Shibai, H., Armus, L., Arrazola, D., Audard, M., Audley, M. D., Bradford, C. M., Charles, I., Dieleman, P., Doi, Y., Duband, L., Eggens, M., Evers, J., Funaki, I., Gao, J. R., Giard, M., Fernández, A. di Giorgio L. M. González, Griffin, M., Helmich, F. P., Hijmering, R., Huisman, R., Ishihara, D., Isobe, N., Jackson, B., Jacobs, H., Jellema, W., Kamp, I., Kaneda, H., Kawada, M., Kemper, F., Kerschbaum, F., Khosropanah, P., Kohno, K., Kooijman, P. P., Krause, O., van der Kuur, J., Kwon, J., Laauwen, W. M., de Lange, G., Larsson, B., van Loon, D., Madden, S. C., Matsuhara, H., Najarro, F., Nakagawa, T., Naylor, D., Ogawa, H., Onaka, T., Oyabu, S., Poglitsch, A., Reveret, V., Rodriguez, L., Spinoglio, L., Sakon, I., Sato, Y., Shinozaki, K., Shipman, R., Sugita, H., Suzuki, T., van der Tak, F. F. S., Redondo, J. Torres, Wada, T., Wang, S. Y., Wafelbakker, C. K., van Weers, H., Withington, S., Vandenbussche, B., Yamada, T., and Yamamura, I.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Measurements in the infrared wavelength domain allow us to assess directly the physical state and energy balance of cool matter in space, thus enabling the detailed study of the various processes that govern the formation and early evolution of stars and planetary systems in galaxies over cosmic time. Previous infrared missions, from IRAS to Herschel, have revealed a great deal about the obscured Universe, but sensitivity has been limited because up to now it has not been possible to fly a telescope that is both large and cold. SPICA is a mission concept aimed at taking the next step in mid- and far-infrared observational capability by combining a large and cold telescope with instruments employing state-of-the-art ultra-sensitive detectors. The mission concept foresees a 2.5-meter diameter telescope cooled to below 8 K. With cooling provided by mechanical coolers instead of depending on a limited cryogen supply, the mission lifetime can extend significantly beyond the required three years. SPICA offers instrumentation with spectral resolving powers ranging from R ~50 through 11000 in the 17-230 $\mu$m domain as well as R~28.000 spectroscopy between 12 and 18 $\mu$m. Additionally SPICA will provide efficient 30-37 $\mu$m broad band mapping, and polarimetric imaging in the 100-350 $\mu$m range. SPICA will provide unprecedented spectroscopic sensitivity of ~5 x $10^{-20}$ W/m$^2$ (5$\sigma$/1hr) - at least two orders of magnitude improvement over what has been attained to date. With this exceptional leap in performance, new domains in infrared astronomy will become accessible, allowing us, for example, to unravel definitively galaxy evolution and metal production over cosmic time, to study dust formation and evolution from very early epochs onwards, and to trace the formation history of planetary systems., Comment: 34 pages, 22 figures, paper accepted for publication in PASA on 2nd February 2018, part of the PASA SPICA Special Issue
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- 2018
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47. Interplanetary Scintillation with the Murchison Widefield Array I: A sub-arcsecond Survey over 900 square degrees at 79 and 158 MHz
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Morgan, J . S., Macquart, J-P., Ekers, R., Chhetri, R., Tokumaru, M., Manoharan, P. K., Tremblay, S., Bisi, M. M., and Jackson, B. V.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present the first dedicated observations of Interplanetary Scintillation (IPS) with the Murchison Widefield Array (MWA). We have developed a synthesis imaging technique, tailored to the properties of modern "large-N" low-frequency radio telescopes. This allows us to image the variability on IPS timescales across 900 square degrees simultaneously. We show that for our observations, a sampling rate of just 2Hz is sufficient to resolve the IPS signature of most sources. We develop tests to ensure that IPS variability is separated from ionospheric or instrumental variability. We validate our results by comparison with existing catalogues of IPS sources, and near-contemporaneous observations by other IPS facilities. Using just five minutes of data, we produce catalogues at both 79MHz and 158MHz, each containing over 350 scintillating sources. At the field centre we detect approximately one scintillating source per square degree, with a minimum scintillating flux density at 158MHz of 110mJy, corresponding to a compact flux density of approximately 400mJy. Each of these sources is a known radio source, however only a minority were previously known to contain sub-arcsecond components. We discuss our findings and the prospects they hold for future astrophysical and heliospheric studies., Comment: Accepted for publication in MNRAS. The catalogues (Tables 2&3) in both VOTable and csv formats are made available as arxiv ancillary files
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- 2017
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48. Anticancer Activity of 4-Aryl-1,4-Dihydropyridines.
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Oliveira, Thaís A. S., Silva, Jackson B. A., Esperandim, Tábata R., Acésio, Nathália O., Tavares, Denise C., and Crotti, Antônio E. M.
- Subjects
- *
HELA cells , *CYTOTOXINS , *CELL survival , *LEAD compounds , *CANCER cells , *BREAST - Abstract
We have synthesized 22 symmetric and asymmetric 4-aryl-1,4-dihydropyridines (1,4-DHPs) by a "green" microwave-assisted one-pot multicomponent Hantzsch reaction and evaluated their cytotoxicity to three human cancer cell lines regarding U-251MG (human glioblastoma), HeLa 229 (human cervical adenocarcinoma), and MCF-7 (human breast carcinoma). None of the 1,4-DHPs were cytotoxic to U-251MG cells. Most of the 1,4-DHPs did not affect HeLa 229 or MCF-7 cell viability. On the other hand, symmetric 1,4-DHPs 18 (diethyl 4-(4-benzyloxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate), 19 (diethyl 4-(4-bromophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate), and 20 (diethyl 4-(3-fluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate) reduced the HeLa (IC50 = 3.6, 2.3, and 4.1 µM, respectively) and MCF-7 (IC50 = 5.2, 5.7, and 11.9 µM, respectively) cell viability. These 1,4-DHPs were more cytotoxic to the HeLa and MCF-7 cells than to the GM07492 (normal human fibroblast) cells, as evidenced by their selectivity indexes. Therefore,1,4-DHPs 18, 19, and 20 may serve as novel lead compounds to discover other 1,4-DHP derivatives with improved anticancer potency and selectivity. [ABSTRACT FROM AUTHOR]
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- 2024
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49. Antileishmanial and Antifungal Activities of Volatile Oils from Cinnamomum Cassia Bark and Schinus Molle Leaves.
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da Silva, Aternoskaires S. R., Fernandes, Cassia C., dos Santos, Daiane A., Mazza, Marya C. M., Silva, Jackson B. A., Magalhães, Lizandra G., Pires, Regina H., Miranda, Mayker L. D., and Crotti, Antônio E. M.
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- 2024
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50. Optimising the multiplex factor of the frequency domain multiplexed readout of the TES-based microcalorimeter imaging array for the X-IFU instrument on the Athena Xray observatory
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van der Kuur, J., Gottardi, L. G., Akamatsu, H., van Leeuwen, B. J., Hartog, R. den, Haas, D., Kiviranta, M., and Jackson, B. J.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Instrumentation and Detectors - Abstract
Athena is a space-based X-ray observatory intended for exploration of the hot and energetic universe. One of the science instruments on Athena will be the X-ray Integrated Field Unit (X-IFU), which is a cryogenic X-ray spectrometer, based on a large cryogenic imaging array of Transition Edge Sensors (TES) based microcalorimeters operating at a temperature of 100mK. The imaging array consists of 3800 pixels providing 2.5 eV spectral resolution, and covers a field of view with a diameter of of 5 arc minutes. Multiplexed readout of the cryogenic microcalorimeter array is essential to comply with the cooling power and complexity constraints on a space craft. Frequency domain multiplexing has been under development for the readout of TES-based detectors for this purpose, not only for the X-IFU detector arrays but also for TES-based bolometer arrays for the Safari instrument of the Japanese SPICA observatory. This paper discusses the design considerations which are applicable to optimise the multiplex factor within the boundary conditions as set by the space craft. More specifically, the interplay between the science requirements such as pixel dynamic range, pixel speed, and cross talk, and the space craft requirements such as the power dissipation budget, available bandwidth, and electromagnetic compatibility will be discussed.
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- 2016
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