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3. Banff 2022 Liver Group Meeting report: Monitoring long-term allograft health

Author

Bellamy, Christopher O.C., O'Leary, Jacqueline G., Adeyi, Oyedele, Baddour, Nahed, Batal, Ibrahim, Bucuvalas, John, Del Bello, Arnaud, El Hag, Mohamed, El-Monayeri, Magda, Farris, Alton B., III, Feng, Sandy, Fiel, Maria Isabel, Fischer, Sandra E., Fung, John, Grzyb, Krzysztof, Guimei, Maha, Haga, Hironori, Hart, John, Jackson, Annette M., Jaeckel, Elmar, Khurram, Nigar A., Knechtle, Stuart J., Lesniak, Drew, Levitsky, Josh, McCaughan, Geoff, McKenzie, Catriona, Mescoli, Claudia, Miquel, Rosa, Minervini, Marta I., Nasser, Imad Ahmad, Neil, Desley, O'Neil, Maura F., Pappo, Orit, Randhawa, Parmjeet, Ruiz, Phillip, Fueyo, Alberto Sanchez, Schady, Deborah, Schiano, Thomas, Sebagh, Mylene, Smith, Maxwell, Stevenson, Heather L., Taner, Timucin, Taubert, Richard, Thung, Swan, Trunecka, Pavel, Wang, Hanlin L., Wood-Trageser, Michelle, Yilmaz, Funda, Zen, Yoh, Zeevi, Adriana, and Demetris, Anthony J.

Published
2024
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4. The evolving use of biomarkers in heart transplantation: Consensus of an expert panel

Author

Kobashigawa, Jon, Hall, Shelly, Agbor-Enoh, Sean, Bray, Robert, Cadeiras, Martin, Chang, Patty, Chih, Sharon, Eisen, Howie, Farr, Maryjane, Fine, Barry, Ghafourian, Kambiz, Halloran, Phil, Jackson, Annette M, Kao, Andrew, Khush, Kiran K, Madabhushi, Anant, Margulies, Kenneth B, Sani, Maryam Mojarrad, Patel, Jignesh K, Patel, Nikhil, Peyster, Eliot, Parwani, Anil, Pinney, Sean, Schlendorf, Kelley, Shah, Keyur, Shah, Palak, Stehlik, Josef, Tambur, Anat, Zeevi, Adriana, Hall, Shelley, Jackson, Annette M., Khush, Kiran K., Margulies, Kenneth B., and Patel, Jignesh K.

Published
2023
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5. The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts

Author

Roufosse, Candice, Naesens, Maarten, Haas, Mark, Lefaucheur, Carmen, Mannon, Roslyn B., Afrouzian, Marjan, Alachkar, Nada, Aubert, Olivier, Bagnasco, Serena M., Batal, Ibrahim, Bellamy, Chris O.C., Broecker, Verena, Budde, Klemens, Clahsen-Van Groningen, Marian, Coley, Shana M., Cornell, Lynn D., Dadhania, Darshana, Demetris, Anthony J., Einecke, Gunilla, Farris, Alton B., Fogo, Agnes B., Friedewald, John, Gibson, Ian W., Horsfield, Catherine, Huang, Edmund, Husain, Syed A., Jackson, Annette M., Kers, Jesper, Kikić, Željko, Klein, Amanda, Kozakowski, Nicolas, Liapis, Helen, Mangiola, Massima, Montgomery, Robert A., Nankinvell, Brian, Neil, Desley A.H., Nickerson, Peter, Rabant, Marion, Randhawa, Parmjeet, Riella, Leonardo V., Rosales, Ivy, Royal, Virginie, Sapir-Pichhadze, Ruth, Sarder, Pinaki, Sarwal, Minnie, Schinstock, Carrie, Stegall, Mark, Solez, Kim, van der Laak, Jeroen, Wiebe, Chris, Colvin, Robert B., Loupy, Alexandre, and Mengel, Michael

Published
2024
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6. Addressing sex-based disparities in solid organ transplantation in the United States – a conference report

Author

Sawinski, Deirdre, Lai, Jennifer C., Pinney, Sean, Gray, Alice L., Jackson, Annette M., Stewart, Darren, Levine, Deborah Jo, Locke, Jayme E., Pomposelli, James J., Hartwig, Matthew G., Hall, Shelley A., Dadhania, Darshana M., Cogswell, Rebecca, Perez, Richard V., Schold, Jesse D., Turgeon, Nicole A., Kobashigawa, Jon, Kukreja, Jasleen, Magee, John C., Friedewald, John, Gill, John S., Loor, Gabriel, Heimbach, Julie K., Verna, Elizabeth C., Walsh, Mary Norine, Terrault, Norah, Testa, Guiliano, Diamond, Joshua M., Reese, Peter P., Brown, Kimberly, Orloff, Susan, Farr, Maryjane A., Olthoff, Kim M., Siegler, Mark, Ascher, Nancy, Feng, Sandy, Kaplan, Bruce, and Pomfret, Elizabeth

Published
2023
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10. Evidence of Chronic Allograft Injury in Liver Biopsies From Long-term Pediatric Recipients of Liver Transplants

Author

Feng, Sandy, Bucuvalas, John C, Demetris, Anthony J, Burrell, Bryna E, Spain, Katherine M, Kanaparthi, Sai, Magee, John C, Ikle, David, Lesniak, Andrew, Lozano, Juan J, Alonso, Estella M, Bray, Robert A, Bridges, Nancy E, Doo, Edward, Gebel, Howard M, Gupta, Nitika A, Himes, Ryan W, Jackson, Annette M, Lobritto, Steven J, Mazariegos, George V, Ng, Vicky L, Rand, Elizabeth B, Sherker, Averell H, Sundaram, Shikha, Turmelle, Yumirle P, and Sanchez-Fueyo, Alberto

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Chronic Liver Disease and Cirrhosis, Transplantation, Liver Disease, Clinical Research, Rare Diseases, Digestive Diseases, Genetics, Organ Transplantation, Oral and gastrointestinal, Adolescent, Allografts, Biopsy, Child, Chronic Disease, Cross-Sectional Studies, Female, Graft Rejection, Humans, Liver, Liver Function Tests, Liver Transplantation, Male, Time Factors, Young Adult, ALT, DSA, Immune Response, Prognostic Factor, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

Background & aimsA substantial proportion of pediatric liver transplant recipients develop subclinical chronic allograft injury. We studied whether there are distinct patterns of injury based on histopathologic features and identified associated immunologic profiles.MethodsWe conducted a cross-sectional study of 157 stable, long-term pediatric recipients of transplanted livers (70 boys; > 6 years old at time of transplantation; mean, 8.9 ± 3.46 years after liver transplantation) who underwent liver biopsy analysis from August 13, 2012, through May 1, 2014. Participants had received livers from a living or deceased donor and had consistently normal results from liver tests. Liver biopsy specimens were scored by a central pathologist; an unsupervised hierarchical cluster analysis of histologic features was used to sort biopsy samples into 3 clusters. We conducted transcriptional and cytometric analyses of liver tissue samples and performed a systems biology analysis that incorporated clinical, serologic, histologic, and transcriptional data.ResultsThe mean level of alanine aminotransferase in participants was 27.6 ± 14.57 U/L, and the mean level of γ-glutamyl transferase was 17.4 ± 7.93 U/L. Cluster 1 was characterized by interface activity (n = 34), cluster 2 was characterized by periportal or perivenular fibrosis without interface activity (n = 45), and cluster 3 had neither feature (n = 78). We identified a module of genes whose expression correlated with levels of alanine aminotransferase, class II donor-specific antibody, portal inflammation, interface activity, perivenular inflammation, portal and perivenular fibrosis, and cluster assignment. The module was enriched in genes that regulate T-cell-mediated rejection (TCMR) of liver and other transplanted organs. Functional pathway analysis showed overrepresentation of TCMR gene sets for cluster 1 but not clusters 2 or 3.ConclusionIn an analysis of biopsies from an apparently homogeneous group of stable, long-term pediatric liver transplant recipients with consistently normal liver test results, we found evidence of chronic graft injury (inflammation and/or fibrosis). Biopsy samples with interface activity had a gene expression pattern associated with TCMR.

Published
2018

11. Complement-activating donor-specific anti-HLA antibodies and solid organ transplant survival: A systematic review and meta-analysis.

Author

Bouquegneau, Antoine, Loheac, Charlotte, Aubert, Olivier, Bouatou, Yassine, Viglietti, Denis, Empana, Jean-Philippe, Ulloa, Camilo, Murad, Mohammad Hassan, Legendre, Christophe, Glotz, Denis, Jackson, Annette M, Zeevi, Adriana, Schaub, Stephan, Taupin, Jean-Luc, Reed, Elaine F, Friedewald, John J, Tyan, Dolly B, Süsal, Caner, Shapiro, Ron, Woodle, E Steve, Hidalgo, Luis G, O'Leary, Jacqueline, Montgomery, Robert A, Kobashigawa, Jon, Jouven, Xavier, Jabre, Patricia, Lefaucheur, Carmen, and Loupy, Alexandre

Subjects
Humans, Antibodies, HLA Antigens, Complement Activation, Transplantation Immunology, Graft Rejection, Graft Survival, General & Internal Medicine, Medical and Health Sciences
Abstract

BACKGROUND:Anti-human leukocyte antigen donor-specific antibodies (anti-HLA DSAs) are recognized as a major barrier to patients' access to organ transplantation and the major cause of graft failure. The capacity of circulating anti-HLA DSAs to activate complement has been suggested as a potential biomarker for optimizing graft allocation and improving the rate of successful transplantations. METHODS AND FINDINGS:To address the clinical relevance of complement-activating anti-HLA DSAs across all solid organ transplant patients, we performed a meta-analysis of their association with transplant outcome through a systematic review, from inception to January 31, 2018. The primary outcome was allograft loss, and the secondary outcome was allograft rejection. A comprehensive search strategy was conducted through several databases (Medline, Embase, Cochrane, and Scopus). A total of 5,861 eligible citations were identified. A total of 37 studies were included in the meta-analysis. Studies reported on 7,936 patients, including kidney (n = 5,991), liver (n = 1,459), heart (n = 370), and lung recipients (n = 116). Solid organ transplant recipients with circulating complement-activating anti-HLA DSAs experienced an increased risk of allograft loss (pooled HR 3.09; 95% CI 2.55-3.74, P = 0.001; I2 = 29.3%), and allograft rejection (pooled HR 3.75; 95% CI: 2.05-6.87, P = 0.001; I2 = 69.8%) compared to patients without complement-activating anti-HLA DSAs. The association between circulating complement-activating anti-HLA DSAs and allograft failure was consistent across all subgroups and sensitivity analyses. Limitations of the study are the observational and retrospective design of almost all included studies, the higher proportion of kidney recipients compared to other solid organ transplant recipients, and the inclusion of fewer studies investigating allograft rejection. CONCLUSIONS:In this study, we found that circulating complement-activating anti-HLA DSAs had a significant deleterious impact on solid organ transplant survival and risk of rejection. The detection of complement-activating anti-HLA DSAs may add value at an individual patient level for noninvasive biomarker-guided risk stratification. TRIAL REGISTRATION:National Clinical Trial protocol ID: NCT03438058.

Published
2018

12. Corrigendum: Novel Non-Histocompatibility Antigen Mismatched Variants Improve the Ability to Predict Antibody-Mediated Rejection Risk in Kidney Transplant.

Author

Pineda, Silvia, Sigdel, Tara K, Chen, Jieming, Jackson, Annette M, Sirota, Marina, and Sarwal, Minnie M

Subjects
antibody-mediated rejection, exome sequencing, gene expression, kidney organ transplant, machine learning, non-histocompatibility antigen, Renal and Urogenital, Immunology, Medical Microbiology
Abstract

[This corrects the article on p. 1687 in vol. 8, PMID: 29259604.].

Published
2018

13. Novel Non-Histocompatibility Antigen Mismatched Variants Improve the Ability to Predict Antibody-Mediated Rejection Risk in Kidney Transplant

Author

Pineda, Silvia, Sigdel, Tara K, Chen, Jieming, Jackson, Annette M, Sirota, Marina, and Sarwal, Minnie M

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Immunology, Genetics, Organ Transplantation, Kidney Disease, Transplantation, Biotechnology, Human Genome, Renal and urogenital, Good Health and Well Being, kidney organ transplant, antibody-mediated rejection, exome sequencing, non-histocompatibility antigen, gene expression, machine learning, Medical Microbiology, Biochemistry and cell biology
Abstract

Transplant rejection is the critical clinical end-point limiting indefinite survival after histocompatibility antigen (HLA) mismatched organ transplantation. The predominant cause of late graft loss is antibody-mediated rejection (AMR), a process whereby injury to the organ is caused by donor-specific antibodies, which bind to HLA and non-HLA (nHLA) antigens. AMR is incompletely diagnosed as donor/recipient (D/R) matching is only limited to the HLA locus and critical nHLA immunogenic antigens remain to be identified. We have developed an integrative computational approach leveraging D/R exome sequencing and gene expression to predict clinical post-transplant outcome. We performed a rigorous statistical analysis of 28 highly annotated D/R kidney transplant pairs with biopsy-confirmed clinical outcomes of rejection [either AMR or T-cell-mediated rejection (CMR)] and no-rejection (NoRej), identifying a significantly higher number of mismatched nHLA variants in AMR (ANOVA-p-value = 0.02). Using Fisher's exact test, we identified 123 variants associated mainly with risk of AMR (p-value

Published
2018

15. Novel Non-Histocompatibility Antigen Mismatched Variants Improve the Ability to Predict Antibody-Mediated Rejection Risk in Kidney Transplant.

Author

Pineda, Silvia, Sigdel, Tara K, Chen, Jieming, Jackson, Annette M, Sirota, Marina, and Sarwal, Minnie M

Subjects
antibody-mediated rejection, exome sequencing, gene expression, kidney organ transplant, machine learning, non-histocompatibility antigen, Biotechnology, Genetics, Organ Transplantation, Transplantation, Kidney Disease, Human Genome, Renal and urogenital, Immunology, Medical Microbiology
Abstract

Transplant rejection is the critical clinical end-point limiting indefinite survival after histocompatibility antigen (HLA) mismatched organ transplantation. The predominant cause of late graft loss is antibody-mediated rejection (AMR), a process whereby injury to the organ is caused by donor-specific antibodies, which bind to HLA and non-HLA (nHLA) antigens. AMR is incompletely diagnosed as donor/recipient (D/R) matching is only limited to the HLA locus and critical nHLA immunogenic antigens remain to be identified. We have developed an integrative computational approach leveraging D/R exome sequencing and gene expression to predict clinical post-transplant outcome. We performed a rigorous statistical analysis of 28 highly annotated D/R kidney transplant pairs with biopsy-confirmed clinical outcomes of rejection [either AMR or T-cell-mediated rejection (CMR)] and no-rejection (NoRej), identifying a significantly higher number of mismatched nHLA variants in AMR (ANOVA-p-value = 0.02). Using Fisher's exact test, we identified 123 variants associated mainly with risk of AMR (p-value

Published
2017

16. The Banff 2022 Kidney Meeting Work Plan:Data-driven refinement of the Banff Classification for renal allografts

Author

Roufosse, Candice, Naesens, Maarten, Haas, Mark, Lefaucheur, Carmen, Mannon, Roslyn B., Afrouzian, Marjan, Alachkar, Nada, Aubert, Olivier, Bagnasco, Serena M., Batal, Ibrahim, Bellamy, Chris O.C., Broecker, Verena, Budde, Klemens, Clahsen-Van Groningen, Marian, Coley, Shana M., Cornell, Lynn D., Dadhania, Darshana, Demetris, Anthony J., Einecke, Gunilla, Farris, Alton B., Fogo, Agnes B., Friedewald, John, Gibson, Ian W., Horsfield, Catherine, Huang, Edmund, Husain, Syed A., Jackson, Annette M., Kers, Jesper, Kikić, Željko, Klein, Amanda, Kozakowski, Nicolas, Liapis, Helen, Mangiola, Massima, Montgomery, Robert A., Nankinvell, Brian, Neil, Desley A.H., Nickerson, Peter, Rabant, Marion, Randhawa, Parmjeet, Riella, Leonardo V., Rosales, Ivy, Royal, Virginie, Sapir-Pichhadze, Ruth, Sarder, Pinaki, Sarwal, Minnie, Schinstock, Carrie, Stegall, Mark, Solez, Kim, van der Laak, Jeroen, Wiebe, Chris, Colvin, Robert B., Loupy, Alexandre, Mengel, Michael, Roufosse, Candice, Naesens, Maarten, Haas, Mark, Lefaucheur, Carmen, Mannon, Roslyn B., Afrouzian, Marjan, Alachkar, Nada, Aubert, Olivier, Bagnasco, Serena M., Batal, Ibrahim, Bellamy, Chris O.C., Broecker, Verena, Budde, Klemens, Clahsen-Van Groningen, Marian, Coley, Shana M., Cornell, Lynn D., Dadhania, Darshana, Demetris, Anthony J., Einecke, Gunilla, Farris, Alton B., Fogo, Agnes B., Friedewald, John, Gibson, Ian W., Horsfield, Catherine, Huang, Edmund, Husain, Syed A., Jackson, Annette M., Kers, Jesper, Kikić, Željko, Klein, Amanda, Kozakowski, Nicolas, Liapis, Helen, Mangiola, Massima, Montgomery, Robert A., Nankinvell, Brian, Neil, Desley A.H., Nickerson, Peter, Rabant, Marion, Randhawa, Parmjeet, Riella, Leonardo V., Rosales, Ivy, Royal, Virginie, Sapir-Pichhadze, Ruth, Sarder, Pinaki, Sarwal, Minnie, Schinstock, Carrie, Stegall, Mark, Solez, Kim, van der Laak, Jeroen, Wiebe, Chris, Colvin, Robert B., Loupy, Alexandre, and Mengel, Michael

Abstract

The XVIth Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from September 19 to 23, 2022, as a joint meeting with the Canadian Society of Transplantation. In addition to a key focus on the impact of microvascular inflammation and biopsy-based transcript analysis on the Banff Classification, further sessions were devoted to other aspects of kidney transplant pathology, in particular T cell–mediated rejection, activity and chronicity indices, digital pathology, xenotransplantation, clinical trials, and surrogate endpoints. Although the output of these sessions has not led to any changes in the classification, the key role of Banff Working Groups in phrasing unanswered questions, and coordinating and disseminating results of investigations addressing these unanswered questions was emphasized. This paper summarizes the key Banff Meeting 2022 sessions not covered in the Banff Kidney Meeting 2022 Report paper and also provides an update on other Banff Working Group activities relevant to kidney allografts.

Published
2024

18. Prediction system for risk of allograft loss in patients receiving kidney transplants : international derivation and validation study

Author

Loupy, Alexandre, Aubert, Olivier, Orandi, Babak J, Naesens, Maarten, Bouatou, Yassine, Raynaud, Marc, Divard, Gillian, Jackson, Annette M, Viglietti, Denis, Giral, Magali, Kamar, Nassim, Thaunat, Olivier, Morelon, Emmanuel, Delahousse, Michel, Kuypers, Dirk, Hertig, Alexandre, Rondeau, Eric, Bailly, Elodie, Eskandary, Farsad, Böhmig, Georg, Gupta, Gaurav, Glotz, Denis, Legendre, Christophe, Montgomery, Robert A, Stegall, Mark D, Empana, Jean-Philippe, Jouven, Xavier, Segev, Dorry L, and Lefaucheur, Carmen

Published
2019

23. The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts

Author

Roufosse, Candice, primary, Naesens, Maarten, additional, Haas, Mark, additional, Lefaucheur, Carmen, additional, Mannon, Roslyn B., additional, Afrouzian, Marjan, additional, Alachkar, Nada, additional, Aubert, Olivier, additional, Bagnasco, Serena M., additional, Batal, Ibrahim, additional, Bellamy, Chris O.C., additional, Broecker, Verena, additional, Budde, Klemens, additional, Clahsen-Van Groningen, Marian, additional, Coley, Shana M., additional, Cornell, Lynn D., additional, Dadhania, Darshana, additional, Demetris, Anthony J., additional, Einecke, Gunilla, additional, Farris, Alton B., additional, Fogo, Agnes B., additional, Friedewald, John, additional, Gibson, Ian W., additional, Horsfield, Catherine, additional, Huang, Edmund, additional, Husain, Syed A., additional, Jackson, Annette M., additional, Kers, Jesper, additional, Kikić, Željko, additional, Klein, Amanda, additional, Kozakowski, Nicolas, additional, Liapis, Helen, additional, Mangiola, Massima, additional, Montgomery, Robert A., additional, Nankinvell, Brian, additional, Neil, Desley A.H., additional, Nickerson, Peter, additional, Rabant, Marion, additional, Randhawa, Parmjeet, additional, Riella, Leonardo V., additional, Rosales, Ivy, additional, Royal, Virginie, additional, Sapir-Pichhadze, Ruth, additional, Sarder, Pinaki, additional, Sarwal, Minnie, additional, Schinstock, Carrie, additional, Stegall, Mark, additional, Solez, Kim, additional, van der Laak, Jeroen, additional, Wiebe, Chris, additional, Colvin, Robert B., additional, Loupy, Alexandre, additional, and Mengel, Michael, additional

Published
2023
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25. Late manifestation of alloantibody-associated injury and clinical pulmonary antibody-mediated rejection: Evidence from cell-free DNA analysis

Author

Agbor-Enoh, Sean, Jackson, Annette M., Tunc, Ilker, Berry, Gerald J., Cochrane, Adam, Grimm, David, Davis, Andrew, Shah, Pali, Brown, Anne W., Wang, Yan, Timofte, Irina, Shah, Palak, Gorham, Sasha, Wylie, Jennifer, Goodwin, Natalie, Jang, Moon Kyoo, Marishta, Argit, Bhatti, Kenneth, Fideli, Ulgen, Yang, Yanqin, Luikart, Helen, Cao, Zeling, Pirooznia, Mehdi, Zhu, Jun, Marboe, Charles, Iacono, Aldo, Nathan, Steven D., Orens, Jonathan, Valantine, Hannah A., and Khush, Kiran

Published
2018
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30. Risk factors associated with Hepatitis E virus infection in kidney transplant recipients in a single tertiary Center in the United States

Author

Sakulsaengprapha, Vorada, primary, Wasuwanich, Paul, additional, Thawillarp, Supharerk, additional, Ingviya, Thammasin, additional, Phimphilai, Premporn, additional, Sue, Paul K., additional, Jackson, Annette M., additional, Kraus, Edward S., additional, Teshale, Eyasu H., additional, Kamili, Saleem, additional, and Karnsakul, Wikrom, additional

Published
2023
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31. Diagnostic Potential of Minimally Invasive Biomarkers:A Biopsy-centered Viewpoint from the Banff Minimally Invasive Diagnostics Working Group

Author

Huang, Edmund, Mengel, Michael, Clahsen-Van Groningen, Marian C., Jackson, Annette M., Huang, Edmund, Mengel, Michael, Clahsen-Van Groningen, Marian C., and Jackson, Annette M.

Abstract

With recent advances and commercial implementation of minimally invasive biomarkers in kidney transplantation, new strategies for the surveillance of allograft health are emerging. Blood and urine-based biomarkers can be used to detect the presence of rejection, but their applicability as diagnostic tests has not been studied. A Banff working group was recently formed to consider the potential of minimally invasive biomarkers for integration into the Banff classification for kidney allograft pathology. We review the existing data on donor-derived cell-free DNA, blood and urine transcriptomics, urinary protein chemokines, and next-generation diagnostics and conclude that the available data do not support their use as stand-alone diagnostic tests at this point. Future studies assessing their ability to distinguish complex phenotypes, differentiate T cell-mediated rejection from antibody-mediated rejection, and function as an adjunct to histology are needed to elevate these minimally invasive biomarkers from surveillance tests to diagnostic tests.

Published
2023

48. Diagnostic Potential of Minimally Invasive Biomarkers: A Biopsy-centered Viewpoint From the Banff Minimally Invasive Diagnostics Working Group

Author

Huang, Edmund, Mengel, Michael, Clahsen-van Groningen, Marian C., and Jackson, Annette M.

Abstract

With recent advances and commercial implementation of minimally invasive biomarkers in kidney transplantation, new strategies for the surveillance of allograft health are emerging. Blood and urine-based biomarkers can be used to detect the presence of rejection, but their applicability as diagnostic tests has not been studied. A Banff working group was recently formed to consider the potential of minimally invasive biomarkers for integration into the Banff classification for kidney allograft pathology. We review the existing data on donor-derived cell-free DNA, blood and urine transcriptomics, urinary protein chemokines, and next-generation diagnostics and conclude that the available data do not support their use as stand-alone diagnostic tests at this point. Future studies assessing their ability to distinguish complex phenotypes, differentiate T cell–mediated rejection from antibody-mediated rejection, and function as an adjunct to histology are needed to elevate these minimally invasive biomarkers from surveillance tests to diagnostic tests.

Published
2023
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50. Efficacy and Safety of Immunosuppression Withdrawal in Pediatric Liver Transplant Recipients: Moving Toward Personalized Management

Author

Feng, Sandy, primary, Bucuvalas, John C., additional, Mazariegos, George V., additional, Magee, John C., additional, Sanchez‐Fueyo, Alberto, additional, Spain, Katharine M., additional, Lesniak, Andrew, additional, Kanaparthi, Sai, additional, Perito, Emily, additional, Venkat, Veena L., additional, Burrell, Bryna E., additional, Alonso, Estella M., additional, Bridges, Nancy D., additional, Doo, Edward, additional, Gupta, Nitika A., additional, Himes, Ryan W., additional, Ikle, David, additional, Jackson, Annette M., additional, Lobritto, Steven J., additional, Jose Lozano, Juan, additional, Martinez, Mercedes, additional, Ng, Vicky L., additional, Rand, Elizabeth B., additional, Sherker, Averell H., additional, Sundaram, Shikha S., additional, Turmelle, Yumirle P., additional, Wood‐Trageser, Michele, additional, and Demetris, Anthony J., additional

Published
2021
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