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In addition to microgravity, spaceflight simultaneously exposes biology to a suite of other stimuli. For example, in space, organisms experience ionizing radiation environments that significantly differ in both quality and quantity from those normally experienced on Earth. However, data on radiation exposure during space missions is often complex to access and to understand, limiting progress towards defining how radiation affects organisms against the unique background of spaceflight. To help address this challenge, we have developed the Rad-Bio-App. This web-accessible database imports radiation metadata from experiments archived in NASA’s GeneLab data repository, and then allows the user to explore these experiments both in the context of their radiation exposure and through their other metadata and results. Rad-Bio-App provides an easy-to-use, graphically-driven environment to enable both radiation biologists and non-specialist researchers to visualize, and understand the impact of ionizing radiation on various biological systems in the context of spaceflight.

Summary Background Since August, 2019, US public health officials have been investigating a national outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI). A spectrum of histological patterns consistent with acute to subacute lung injury has been seen in biopsies; however, autopsy findings have not been systematically characterised. We describe the pathological findings in autopsy and biopsy tissues submitted to the US Centers for Disease Control and Prevention (CDC) for the evaluation of suspected EVALI. Methods Between Aug 1, 2019, and Nov 30, 2019, we examined lung biopsy (n=10 individuals) and autopsy (n=13 individuals) tissue samples received by the CDC, submitted by 16 US states, from individuals with: a history of e-cigarette, or vaping, product use; respiratory, gastrointestinal, or constitutional symptoms; and either pulmonary infiltrates or opacities on chest imaging, or sudden death from an undetermined cause. We also reviewed medical records, evaluated histopathology, and performed infectious disease testing when indicated by histopathology and clinical history. Findings 21 cases met surveillance case definitions for EVALI, with a further two cases of clinically suspected EVALI evaluated. All ten lung biopsies showed histological evidence of acute to subacute lung injury, including diffuse alveolar damage or organising pneumonia. These patterns were also seen in nine of 13 (69%) autopsy cases, most frequently diffuse alveolar damage (eight autopsies), but also acute and organising fibrinous pneumonia (one autopsy). Additional pulmonary pathology not necessarily consistent with EVALI was seen in the remaining autopsies, including bronchopneumonia, bronchoaspiration, and chronic interstitial lung disease. Three of the five autopsy cases with no evidence of, or a plausible alternative cause for acute lung injury, had been classified as confirmed or probable EVALI according to surveillance case definitions. Interpretation Acute to subacute lung injury patterns were seen in all ten biopsies and most autopsy lung tissues from individuals with suspected EVALI. Acute to subacute lung injury can have numerous causes; however, if it is identified in an individual with a history of e-cigarette, or vaping, product use, and no alternative cause is apparent, a diagnosis of EVALI should be strongly considered. A review of autopsy tissue pathology in suspected EVALI deaths can also identify alternative diagnoses, which can enhance the specificity of public health surveillance efforts. Funding US Centers for Disease Control and Prevention.

Introduction Cligosiban is an orally administered, centrally penetrant oxytocin receptor antagonist being developed to treat premature ejaculation (PE). Aim To determine the efficacy of 3 dose levels of cligosiban caplets to prolong intravaginal ejaculation latency time (IELT) and improve patient-reported outcomes in men with lifelong PE. Methods Patients recorded details of at least 4 sexual intercourse events during a 4-week run-in period, after which they underwent baseline assessments. Patients were eligible for the study if their stopwatch-assessed IELT was ≤1 minute in ≥75% of intercourse attempts and if they met other diagnostic criteria for lifelong PE. Eligible patients (target 220 evaluable) were randomized to double-blind cligosiban 400, 800, or 1200 mg or matching placebo caplets (to be taken 1 to 6 hours prior to sexual activity). Assessments were conducted at 2, 4, and 8 weeks. Main Outcome Measure Efficacy measures were comprised of IELT, self-rating of ejaculation control and ejaculation-related distress (recorded in an electronic diary after each intercourse attempt), premature ejaculation profile, Patient’s Global Impression of Severity, and the Clinical Global Impression of Change. Results There were no clinically or statistically significant differences between cligosiban (at any dose level) and placebo for the primary endpoint (change in geometric IELT) or any of the secondary endpoints. Cligosiban was well tolerated with a side-effect profile similar to placebo. Clinical Implications This Phase IIb study failed to demonstrate the potential for cligosiban, an oxytocin antagonist, to successfully treat symptoms of severe lifelong PE at doses up to 1200 mg. Strengths and Limitations This was a Phase IIb, randomized, double-blind, placebo-controlled study that was adequately powered but failed to detect a clinically meaningful or statistical difference in change in IELT between cligosiban at 3 dose levels and placebo. This is in contrast to a similarly designed proof-of-concept study where cligosiban was flexibly dosed at doses up to 800 mg and did demonstrate clinically meaningful and statistically significant changes in efficacy parameters. The reasons for this disparity are not known. Conclusions Cligosiban was well tolerated but failed to demonstrate efficacy for the treatment of men with lifelong PE at doses up to 1200 mg.

Research on astronaut health and model organisms have revealed six features of spaceflight biology that guide our current understanding of fundamental molecular changes that occur during space travel. The features include oxidative stress, DNA damage, mitochondrial dysregulation, epigenetic changes (including gene regulation), telomere length alterations, and microbiome shifts. Here we review the known hazards of human spaceflight, how spaceflight affects living systems through these six fundamental features, and the associated health risks of space exploration. We also discuss the essential issues related to the health and safety of astronauts involved in future missions, especially planned long-duration and Martian missions.

Background: Ionizing radiation from galactic cosmic rays (GCR) is one of the major risk factors that will impact the health of astronauts on extended missions outside the protective effects of the Earth&rsquo, s magnetic field. The NASA GeneLab project has detailed information on radiation exposure using animal models with curated dosimetry information for spaceflight experiments. Methods: We analyzed multiple GeneLab omics datasets associated with both ground-based and spaceflight radiation studies that included in vivo and in vitro approaches. A range of ions from protons to iron particles with doses from 0.1 to 1.0 Gy for ground studies, as well as samples flown in low Earth orbit (LEO) with total doses of 1.0 mGy to 30 mGy, were utilized. Results: From this analysis, we were able to identify distinct biological signatures associating specific ions with specific biological responses due to radiation exposure in space. For example, we discovered changes in mitochondrial function, ribosomal assembly, and immune pathways as a function of dose. Conclusions: We provided a summary of how the GeneLab&rsquo, s rich database of omics experiments with animal models can be used to generate novel hypotheses to better understand human health risks from GCR exposures.

Accurate assessment of risks of long-term space missions is critical for human space exploration. It is essential to have a detailed understanding of the biological effects on humans living and working in deep space. Ionizing radiation from galactic cosmic rays (GCR) is a major health risk factor for astronauts on extended missions outside the protective effects of the Earth's magnetic field. Currently, there are gaps in our knowledge of the health risks associated with chronic low-dose, low-dose-rate ionizing radiation, specifically ions associated with high (H) atomic number (Z) and energy (E). The NASA GeneLab project ( https://genelab.nasa.gov/ ) aims to provide a detailed library of omics datasets associated with biological samples exposed to HZE. The GeneLab Data System (GLDS) includes datasets from both spaceflight and ground-based studies, a majority of which involve exposure to ionizing radiation. In addition to detailed information on radiation exposure for ground-based studies, GeneLab is adding detailed, curated dosimetry information for spaceflight experiments. GeneLab is the first comprehensive omics database for space-related research from which an investigator can generate hypotheses to direct future experiments, utilizing both ground and space biological radiation data. The GLDS is continually expanding as omics-related data are generated by the space life sciences community. Here we provide a brief summary of the space radiation-related data available at GeneLab.

An operation implementation of a passive microwave sea ice concentration algorithm to support NOAA's operational mission is presented. The NASA team 2 algorithm, previously developed for the NASA advanced microwave scanning radiometer for the Earth observing system (AMSR-E) product suite, is adapted for operational use with the JAXA AMSR2 sensor through several enhancements. First, the algorithm is modified to process individual swaths and provide concentration from the most recent swaths instead of a 24-hour average. A latency (time since observation) field and a 24-hour concentration range (maximum–minimum) are included to provide indications of data timeliness and variability. Concentration from the Bootstrap algorithm is a secondary field to provide complementary sea ice information. A quality flag is implemented to provide information on interpolation, filtering, and other quality control steps. The AMSR2 concentration fields are compared with a different AMSR2 passive microwave product, and then validated via comparison with sea ice concentration from the Suomi visible and infrared imaging radiometer suite. This validation indicates the AMSR2 concentrations have a bias of 3.9% and an RMSE of 11.0% in the Arctic, and a bias of 4.45% and RMSE of 8.8% in the Antarctic. In most cases, the NOAA operational requirements for accuracy are met. However, in low-concentration regimes, such as during melt and near the ice edge, errors are higher because of the limitations of passive microwave sensors and the algorithm retrieval.

In this study, we demonstrate skillful spring forecasts of detrended September Arctic sea ice extent using passive microwave observations of sea ice concentration (SIC) and melt onset (MO). We compare these to forecasts produced using data from a sophisticated melt pond model, and find similar to higher skill values, where the forecast skill is calculated relative to linear trend persistence. The MO forecasts shows the highest skill in March–May, while the SIC forecasts produce the highest skill in June–August, especially when the forecasts are evaluated over recent years (since 2008). The high MO forecast skill in early spring appears to be driven primarily by the presence and timing of open water anomalies, while the high SIC forecast skill appears to be driven by both open water and surface melt processes. Spatial maps of detrended anomalies highlight the drivers of the different forecasts, and enable us to understand regions of predictive importance. Correctly capturing sea ice state anomalies, along with changes in open water coverage appear to be key processes in skillfully forecasting summer Arctic sea ice.

The space radiation environment is a complex mixture of particle types and energies originating from sources inside and outside of the galaxy. These environments may be modified by the heliospheric and geomagnetic conditions as well as planetary bodies and vehicle or habitat mass shielding. In low Earth orbit (LEO), the geomagnetic field deflects a portion of the galactic cosmic rays (GCR) and all but the most intense solar particle events (SPE). There are also dynamic belts of trapped electrons and protons with low to medium energy and intense particle count rates. In deep space, the GCR exposure is more severe than in LEO and varies inversely with solar activity. Unpredictable solar storms also present an acute risk to astronauts if adequate shielding is not provided. Near planetary surfaces such as the Earth, moon or Mars, secondary particles are produced when the ambient deep space radiation environment interacts with these surfaces and/or atmospheres. These secondary particles further complicate the local radiation environment and modify the associated health risks. Characterizing the radiation fields in this vast array of scenarios and environments is a challenging task and is currently accomplished with a combination of computational models and dosimetry. The computational tools include models for the ambient space radiation environment, mass shielding geometry, and atomic and nuclear interaction parameters. These models are then coupled to a radiation transport code to describe the radiation field at the location of interest within a vehicle or habitat. Many new advances in these models have been made in the last decade, and the present review article focuses on the progress and contributions made by workers and collaborators at NASA Langley Research Center in the same time frame. Although great progress has been made, and models continue to improve, significant gaps remain and are discussed in the context of planned future missions. Of particular interest is the juxtaposition of various review committee findings regarding the accuracy and gaps of combined space radiation environment, physics, and transport models with the progress achieved over the past decade. While current models are now fully capable of characterizing radiation environments in the broad range of forecasted mission scenarios, it should be remembered that uncertainties still remain and need to be addressed.

Space radiation has recently been considered a risk factor for astronauts&rsquo, cardiac health. As an example, for the case of how to query and identify datasets within NASA&rsquo, s GeneLab database and demonstrate the database utility, we used an unbiased systems biology method for identifying key genes/drivers for the contribution of space radiation on the cardiovascular system. This knowledge can contribute to designing appropriate experiments targeting these specific pathways. Microarray data from cardiomyocytes of male C57BL/6 mice followed-up for 28 days after exposure to 900 mGy of 1 GeV proton or 150 mGy of 1 GeV/n 56Fe were compared to human endothelial cells (HUVECs) cultured for 7 days on the International Space Station (ISS). We observed common molecular pathways between simulated space radiation and HUVECs flown on the ISS. The analysis suggests FYN is the central driver/hub for the cardiovascular response to space radiation: the known oxidative stress induced immediately following radiation would only be transient and would upregulate FYN, which in turn would reduce reactive oxygen species (ROS) levels, protecting the cardiovascular system. The transcriptomic signature of exposure to protons was also much closer to the spaceflight signature than 56Fe&rsquo, s signature. To our knowledge, this is the first time GeneLab datasets were utilized to provide potential biological indications that the majority of ions on the ISS are protons, clearly illustrating the power of omics analysis. More generally, this work also demonstrates how to combine animal radiation studies done on the ground and spaceflight studies to evaluate human risk in space.

We developed a highly-selective technique to measure the energy loss and linear-energy-transfer (LET) spectra of energetic charged particles in high-resolution and over a large collection of particle-event types. Precise and wide-range spectral and tracking measurements were performed with a single semiconductor pixel detector. The quantum-counting sensitivity, high-granularity and per-pixel spectrometric response of the Timepix ASIC chip enable the detailed spectral-tracking registration of single charged particles across the detector semiconductor sensor. Both the deposited energy along the particle trajectory (energy loss) and the path length of the particle track across the semiconductor sensor are precisely measured for each particle. This allows for the determination of the particle LET in silicon in high accuracy and over a wide-range of energies, particle types and directions. The tracking and energy loss response together with the resolving power at the particle-event level make it possible to selectively provide LET distributions of the light and heavy charged particle components in mixed-radiation and omnidirectional fields. This technique applies to energetic (E > 10 MeV/u) charged particles generating tracks greater than the pixel size and incident at non-perpendicular direction ( > 2 0 ∘ ) to the sensor plane. The technique applies also to electrons of energy above few MeV as well as highly energetic and minimum-ionizing-particles (MIPs). We make use of existing and in part newly collected data at well-defined radiation fields with proton and light ion beam accelerators. Flexible measurements, ease of deployment and online response are possible by the use of compact readout electronics such as the miniaturized radiation camera MiniPix (size 8 cm, weight 50 g) operable by any PC. Results are given for protons and light ions (He, C) of selected energies above 10 MeV/u and directions (2 π FoV). We include also electrons (20 MeV). Selective and detailed LET spectra are produced over a wide range (10−1 to 102 keV/ μ m) in silicon.

Variations in sea ice freeze onset and regional sea surface temperatures (SSTs) in Baffin Bay and Greenland Sea are linked to autumn surface air temperatures (SATs) around coastal Greenland through 500 hPa blocking patterns, 1979–2014. We find strong, statistically significant correlations between Baffin Bay freeze onset and SSTs and SATs across the western and southernmost coastal areas, while weaker and fewer significant correlations are found between eastern SATs, SSTs, and freeze periods observed in the neighboring Greenland Sea. Autumn Greenland Blocking Index values and the incidence of meridional circulation patterns have increased over the modern sea ice monitoring era. Increased anticyclonic blocking patterns promote poleward transport of warm air from lower latitudes and local warm air advection onshore from ocean–atmosphere sensible heat exchange through ice-free or thin ice-covered seas bordering the coastal stations. Temperature composites by years of extreme late freeze conditions, occurring since 2006 in Baffin Bay, reveal positive monthly SAT departures that often exceed 1 standard deviation from the 1981–2010 climate normal over coastal areas that exhibit a similar spatial pattern as the peak correlations.

The Bromine, Ozone, and Mercury Experiment (BROMEX) was conducted in March and April of 2012 near Barrow, Alaska, to investigate impacts of Arctic sea ice reduction on chemical processes. During BROMEX, multiple sensors were deployed to measure air and surface temperature. The uncertainties in temperature measurement on snow-covered land and sea ice surfaces were examined using in situ data and temperature measurements that were derived from the Moderate Resolution Imaging Spectroradiometer (MODIS) and are part of the Terra and Aqua ice-surface temperature and land-surface temperature (LST) standard data products. Following an ~24-h cross-calibration study, two Thermochrons (small temperature-sensing devices) were deployed at each of three field sites: a sea ice site in the Chukchi Sea, a mixed-cover site, and a homogeneous tundra site. At each site, one Thermochron was shielded from direct sunlight and one was left unshielded, and they were placed on top of the snow or ice. The best agreement between the Thermochron- and MODIS-derived temperatures was found between the shielded Thermochrons and the Aqua MODIS LSTs, with an average agreement of 0.6° ± 2.0°C (sample size of 84) at the homogeneous tundra site. The results highlight some uncertainties associated with obtaining consistent air and surface temperature measurements in the harsh Arctic environment, using both in situ and satellite sensors. It is important to minimize uncertainties that could introduce biases in long-term temperature trends.

The Arctic marine environment is undergoing a transition from thick multi-year to first-year sea-ice cover with coincident lengthening of the melt season. Such changes are evident in the Baffin Bay-Davis Strait-Labrador Sea (BDL) region where melt onset has occurred ~8 days decade−1 earlier from 1979 to 2015. A series of anomalously early events has occurred since the mid-1990s, overlapping a period of increased upper-air ridging across Greenland and the northwestern North Atlantic. We investigate an extreme early melt event observed in spring 2013. (~6σ below the 1981–2010 melt climatology), with respect to preceding sub-seasonal mid-tropospheric circulation conditions as described by a daily Greenland Blocking Index (GBI). The 40-days prior to the 2013 BDL melt onset are characterized by a persistent, strong 500 hPa anticyclone over the region (GBI >+1 on >75% of days). This circulation pattern advected warm air from northeastern Canada and the northwestern Atlantic poleward onto the thin, first-year sea ice and caused melt ~50 days earlier than normal. The episodic increase in the ridging atmospheric pattern near western Greenland as in 2013, exemplified by large positive GBI values, is an important recent process impacting the atmospheric circulation over a North Atlantic cryosphere undergoing accelerated regional climate change.

Vaccination of the donor might have prevented infection in the recipient and subsequent transmission to healthcare workers., Although transmission of hepatitis A virus (HAV) through blood transfusion has been documented, transmission through organ transplantation has not been reported. In August 2015, state health officials in Texas, USA, were notified of 2 home health nurses with HAV infection whose only common exposure was a child who had undergone multi–visceral organ transplantation 9 months earlier. Specimens from the nurses, organ donor, and all organ recipients were tested and medical records reviewed to determine a possible infection source. Identical HAV RNA sequences were detected from the serum of both nurses and the organ donor, as well as from the multi–visceral organ recipient’s serum and feces; this recipient’s posttransplant liver and intestine biopsy specimens also had detectable virus. The other organ recipients tested negative for HAV RNA. Vaccination of the donor might have prevented infection in the recipient and subsequent transmission to the healthcare workers.

Two long records of melt onset (MO) on Arctic sea ice from passive microwave brightness temperatures (Tbs) obtained by a series of satellite-borne instruments are compared. The Passive Microwave (PMW) method and Advanced Horizontal Range Algorithm (AHRA) detect the increase in emissivity that occurs when liquid water develops around snow grains at the onset of early melting on sea ice. The timing of MO on Arctic sea ice influences the amount of solar radiation absorbed by the ice–ocean system throughout the melt season by reducing surface albedos in the early spring. This work presents a thorough comparison of these two methods for the time series of MO dates from 1979 through 2012. The methods are first compared using the published data as a baseline comparison of the publically available data products. A second comparison is performed on adjusted MO dates we produced to remove known differences in inter-sensor calibration of Tbs and masking techniques used to develop the original MO date products. These adjustments result in a more consistent set of input Tbs for the algorithms. Tests of significance indicate that the trends in the time series of annual mean MO dates for the PMW and AHRA are statistically different for the majority of the Arctic Ocean including the Laptev, E. Siberian, Chukchi, Beaufort, and central Arctic regions with mean differences as large as 38.3 days in the Barents Sea. Trend agreement improves for our more consistent MO dates for nearly all regions. Mean differences remain large, primarily due to differing sensitivity of in-algorithm thresholds and larger uncertainties in thin-ice regions.

The Arctic-wide melt season has lengthened at a rate of 5 days dec-1 from 1979 to 2013, dominated by later autumn freeze-up within the Kara, Laptev, East Siberian, Chukchi and Beaufort seas between 6 and 11 days dec(exp -1). While melt onset trends are generally smaller, the timing of melt onset has a large influence on the total amount of solar energy absorbed during summer. The additional heat stored in the upper ocean of approximately 752MJ m(exp -2) during the last decade, increases sea surface temperatures by 0.5 to 1.5 C and largely explains the observed delays in autumn freeze-up within the Arctic Ocean's adjacent seas. Cumulative anomalies in total absorbed solar radiation from May through September for the most recent pentad locally exceed 300-400 MJ m(exp -2) in the Beaufort, Chukchi and East Siberian seas. This extra solar energy is equivalent to melting 0.97 to 1.3 m of ice during the summer.

Objective Pseudobulbar Affect (PBA) is defined as dysregulation of emotional expression and is characterized by sudden, uncontrollable, laughing and/or crying that is discordant with the present mood or social context. This study sought to establish the prevalence of PBA symptoms in individuals with a high incidence of sports-related head injuries and explore the relationship between two rating scales designed to measure PBA symptoms. Methods Sixty-three professional fighters (age: M = 44.7, SD = 10.0; 98% male) underwent neurological and neuropsychological assessment including completion of the Pathological Laughing and Crying Scale (PLCS) and the Center for Neurologic Study – Lability Scale (CNS-LS). Diagnostic criteria for PBA were reviewed during the neurological exam to establish the prevalence of the clinical syndrome. Prevalence statistics for item endorsement on the rating scales and diagnostic status were calculated. To investigate the rate of agreement between rating scales, concordance correlation coefficient (CCC) and root mean square difference (RMSD) were calculated. Results Eleven percent of participants met clinical criteria for PBA diagnosis, 25% of participants endorsed clinically significant PBA symptoms on the CNS-LS (M = 10.9, SD = 4.9), and 8% endorsed significant symptoms on the PLCS (M = 3.1, SD = 6.5). The rating scales were significantly positively correlated (r = .58; p < .01), though overall agreement was low (CCC = 0.55; RMSD = 5.4). Conclusions This study demonstrates that the prevalence of PBA symptoms in a sample of professional fighters is not uncommon. Although both the CNS-LS and PCLS are designed to measure PBA symptoms, they appear to be measuring unique aspects of PBA that may provide complimentary, rather than redundant information.

Increasing knowledge concerning the biology of hematologic malignancies as well as the role of the immune system in the control of these diseases has led to the development and approval of immunotherapies that are resulting in impressive clinical responses. Therefore, the Society for Immunotherapy of Cancer (SITC) convened a hematologic malignancy Cancer Immunotherapy Guidelines panel consisting of physicians, nurses, patient advocates, and patients to develop consensus recommendations for the clinical application of immunotherapy for patients with multiple myeloma, lymphoma, and acute leukemia. These recommendations were developed following the previously established process based on the Institute of Medicine’s clinical practice guidelines. In doing so, a systematic literature search was performed for high-impact studies from 2004 to 2014 and was supplemented with further literature as identified by the panel. The consensus panel met in December of 2014 with the goal to generate consensus recommendations for the clinical use of immunotherapy in patients with hematologic malignancies. During this meeting, consensus panel voting along with discussion were used to rate and review the strength of the supporting evidence from the literature search. These consensus recommendations focus on issues related to patient selection, toxicity management, clinical endpoints, and the sequencing or combination of therapies. Overall, immunotherapy is rapidly emerging as an effective therapeutic strategy for the management of hematologic malignances. Evidence-based consensus recommendations for its clinical application are provided and will be updated as the field evolves. Electronic supplementary material The online version of this article (doi:10.1186/s40425-016-0188-z) contains supplementary material, which is available to authorized users.

Highly ionizing atomic nuclei HZE in the GCR will be a significant source of radiation exposure for humans on extended missions outside low Earth orbit. Accelerators such as the LBNL Bevalac and the BNL AGS, designed decades ago for fundamental nuclear and particle physics research, subsequently found use as sources of GCR-like particles for ground-based physics and biology research relevant to space flight. The NASA Space Radiation Laboratory at BNL was constructed specifically for space radiation research. Here we review some of the space-related physics results obtained over the first 20 years of NASA-sponsored research at Brookhaven.

Most accelerator-based space radiation experiments have been performed with single ion beams at fixed energies. However, the space radiation environment consists of a wide variety of ion species with a continuous range of energies. Due to recent developments in beam switching technology implemented at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL), it is now possible to rapidly switch ion species and energies, allowing for the possibility to more realistically simulate the actual radiation environment found in space. The present paper discusses a variety of issues related to implementation of galactic cosmic ray (GCR) simulation at NSRL, especially for experiments in radiobiology. Advantages and disadvantages of different approaches to developing a GCR simulator are presented. In addition, issues common to both GCR simulation and single beam experiments are compared to issues unique to GCR simulation studies. A set of conclusions is presented as well as a discussion of the technical implementation of GCR simulation.

A comparison of snow depths on sea ice was made using airborne altimeters and an Advanced Microwave Scanning Radiometer for the Earth Observing System (AMSR-E) simulator. The data were collected during the March 2006 National Aeronautics and Space Administration (NASA) Arctic field campaign utilizing the NASA P-3B aircraft. The campaign consisted of an initial series of coordinated surface and aircraft measurements over Elson Lagoon, Alaska and adjacent seas followed by a series of large-scale (100 km × 50 km) coordinated aircraft and AMSR-E snow depth measurements over portions of the Chukchi and Beaufort seas. This paper focuses on the latter part of the campaign. The P-3B aircraft carried the University of Colorado Polarimetric Scanning Radiometer (PSR-A), the NASA Wallops Airborne Topographic Mapper (ATM) lidar altimeter, and the University of Kansas Delay-Doppler (D2P) radar altimeter. The PSR-A was used as an AMSR-E simulator, whereas the ATM and D2P altimeters were used in combination to provide an independent estimate of snow depth. Results of a comparison between the altimeter-derived snow depths and the equivalent AMSR-E snow depths using PSR-A brightness temperatures calibrated relative to AMSR-E are presented. Data collected over a frozen coastal polynya were used to intercalibrate the ATM and D2P altimeters before estimating an altimeter snow depth. Results show that the mean difference between the PSR and altimeter snow depths is -2.4 cm (PSR minus altimeter) with a standard deviation of 7.7 cm. The RMS difference is 8.0 cm. The overall correlation between the two snow depth data sets is 0.59.

Human space flight requires protecting astronauts from the harmful effects of space radiation. The availability of measured nuclear cross-section data needed for these studies is reviewed in the present paper. The energy range of interest for radiation protection is approximately 100 MeV/n–10 GeV/n. The majority of data are for projectile fragmentation partial and total cross-sections, including both charge changing and isotopic cross-sections. The cross-section data are organized into categories which include charge changing, elemental, isotopic for total, single and double differential with respect to momentum, energy and angle. Gaps in the data relevant to space radiation protection are discussed and recommendations for future experiments are made.

Exposures were made with Medipix2 TimePix-based Si detectors at the HIMAC facility in Japan to explore the potential for discrimination between tracks with differing charges and energies, but with very similar dE/dx values. Data were taken at 15° increments for a number of different beams including 600 and 800 MeV/A Si, 180 MeV/A Ne and 100 MeV/A O. Data were also obtained for 400 MeV/A Si and 500 MeV/A Fe along with 290 and 180 MeV/A N. The TimePix chips have been calibrated to achieve the maximum resolution. Estimates for the angular resolution for these types of tracks are also possible from these data, which are essential in the development of a TimePix-based dosimetric device for use in a space radiation environment. One of the principal objectives of these data runs was to explore the resolution of TimePix-based Si detectors to discriminate between various ions with different energies and charges, but with similar dE/dx values in Si. Analysis of the images obtained shows the clear differences in the δ-ray halos for particles with similar dE/dx values but for differing charges and energies. These measurements are part of an ongoing program to explore the range of capabilities of the TimePix-based detector with respect to dosimetry uses in space.

It is widely accepted that improvement of the current International System of Units (SI) is necessary, and that central to this problem is redefinition of the kilogram. This paper compares the relative advantages of two main proposals for a modern scientific definition of the kilogram: an ‘electronic kilogram’ based on a fixed value of Planck’s constant, and an ‘atomic kilogram’ based on a fixed value for Avogadro’s number. A concrete and straightforward atomic definition of the kilogram is proposed. This definition is argued to be more experimentally neutral than the electronic kilogram, more realizable by school and university laboratories than the electronic kilogram, and more readily comprehensible than the electronic kilogram.

To meet the challenge of future deep space programs, an accurate and efficient engineering code for analyzing the shielding requirements against high-energy galactic heavy ion radiation is needed. In consequence, a new version of the HZETRN code capable of simulating high charge and energy (HZE) ions with either laboratory or space boundary conditions is currently under development. This code, GRNTRN, is based on a Green’s function approach to the solution of the one-dimensional Boltzmann transport equation and like its predecessor is deterministic in nature. The computational model consists of the lowest order asymptotic approximation followed by a Neumann series expansion with non-perturbative corrections. The physical description includes energy loss with straggling, nuclear attenuation, nuclear fragmentation with energy dispersion and down shift. Code validation in the laboratory environment is addressed by showing that GRNTRN accurately predicts energy loss spectra as measured by solid-state detectors in ion beam experiments with multi-layer targets. In order to verify and benchmark the code with space boundary conditions, measured particle fluxes are propagated through several thicknesses of shielding using both GRNTRN and the current version of HZETRN. The favorable agreement obtained indicates that GRNTRN accurately models the propagation of HZE ions in laboratory settings. It also compares very well with the extensively validated space environment HZETRN code and thus provides verification of the HZETRN propagator.

A critical need for NASA is the ability to accurately model the transport of heavy ions in the Galactic Cosmic Rays (GCR) through matter, including spacecraft walls, equipment racks, etc. Nuclear interactions are of great importance in the GCR transport problem, as they can cause fragmentation of the incoming ion into lighter ions. Since the radiation dose delivered by a particle is proportional to the square of (charge/velocity), fragmentation reduces the dose delivered by incident ions. The other mechanism by which dose can be reduced is ionization energy loss, which can lead to some particles stopping in the shielding. This is the conventional notion of shielding, but it is not applicable to human spaceflight since the particles in the GCR tend to be too energetic to be stopped in the relatively thin shielding that is possible within payload mass constraints. Our group has measured a large number of fragmentation cross sections, intended to be used as input to, or for validation of, NASA's radiation transport models. A database containing over 200 charge-changing cross sections and over 2000 fragment production cross sections has been compiled. In this report, we examine in detail the contrast between fragment measurements at large acceptance and small acceptance. We use output from the PHITS Monte Carlo code to test our assumptions using as an example Ar-40 data (and simulated data) at a beam energy of 650 MeV/nucleon. We also present preliminary analysis in which isotopic resolution was attained for beryllium fragments produced by beams of B-10 and B-11. Future work on the experimental data set will focus on extracting and interpreting production cross sections for light fragments. (C) 2010 COSPAR. Published by Elsevier Ltd. All rights reserved.

We have measured the radiation transport and dose reduction properties of lunar soil with respect to selected heavy ion beams with charges and energies comparable to some components of the galactic cosmic radiation (GCR), using soil samples returned by the Apollo missions and several types of synthetic soil glasses and lunar soil simulants. The suitability for shielding studies of synthetic soil and soil simulants as surrogates for lunar soil was established, and the energy deposition as a function of depth for a particular heavy ion beam passing through a new type of lunar highland simulant was measured. A fragmentation and energy loss model was used to extend the results over a range of heavy ion charges and energies, including protons at solar particle event (SPE) energies. The measurements and model calculations indicate that a modest amount of lunar soil affords substantial protection against primary GCR nuclei and SPE, with only modest residual dose from surviving charged fragments of the heavy beams.

Cyclic peptide structures of the type -Lys-R1—Rn-Glu- can be synthesized on the Merrifield resin by assembling the peptide chain using Nα-Fmoc-amino acids and Boc and tert.-butyl protection for the side-chains of Lys and Glu, respectively. If residues R1 to Rn contain side-chain functional groups, TFA-resistant protection is required. After TFA treatment cyclization on the resin can be performed with appropriate coupling reagents. The formation of such cyclic structures may be preceded or followed by peptide chain assembly using Nα-Boc-amino acids and the entire peptide chain containing the cyclic portion is finally cleaved by HF treatment. Using this principle we synthesized the following opioid peptide related cyclic analogs: H-Tyr-d-Lys-Gly-Phe-Glu-NH2 (I), H-Tyr-Lys-Gly-Phe-Glu-NH2 (II), H-Tyr-d-Lys-Phe-Glu-NH2 (III), H-Tyr-d-Glu-Gly-Phe-Lys-NH2 (IV), H-Tyr-d-Glu-Phe-Lys-NH2 (V), H-Tyr-d-Orn-Gly-Glu-NH2 (VI) and H-Tyr-d-Ala-Lys-Phe-Glu-NH2 (VII). Cyclic monomers were obtained in all cases, as demonstrated by mass spectrometry. Analysis of side-products revealed a slow-down of the HF deprotection of O-benzylated tyrosine as a consequence of hydrophobic interactions as well as the formation of a side-chain-linked antiparallel cyclic dimer in the case of compound VI. In conclusion, the described method permits the convenient preparation of peptide analogs cyclized via amide bond formation between side-chain amino and carboxyl groups in reasonable yield.

Recently, the Monte Carlo transport code HETC has been extended to include the interactions and transport of energetic heavy ions. Here, for the first time, we compare predictions of fragment production and energy loss with laboratory data measured at Brookhaven National Laboratory and at the National Institute of Radiological Sciences in Japan. Very good agreement is found for predicted and measured energy loss spectra for a variety of incident laboratory beams and targets.

Ions of high atomic number and energy (HZE particles) pose a significant cancer risk to astronauts on prolonged space missions. On Earth, similar ions are being used for targeted cancer therapy. The properties of these particles can be drastically altered during passage through spacecraft shielding, therapy beam modulators, or the human body. Here, we have used pertinent responses to DNA double-strand breaks (DSBs) to understand the consequences of energy loss versus nuclear fragmentation of Fe ions during passage through shielding or tissue-equivalent materials. Phosphorylation of histone H2AX and recruitment of 53BP1 were used to generate 3D reconstructions of DNA damage in human cells and to follow its repair. Human cells are unable to repair a significant portion of DNA damage induced by Fe ions. DNA-PK and ATM are required, to different extents, for the partial repair of Fe-induced DNA damage. Aluminum shielding has little effect on DNA damage or its repair, confirming that the hulls of the Space Shuttle and the International Space Station afford scant protection against these particles. Lead shielding, on the other hand, exacerbates the effects of Fe ions due to energy loss during particle traversal. In sharp contrast, polyethylene (PE), a favored hydrogenous shield, results in DNA damage that is more amenable to repair presumably due to Fe-ion fragmentation. Human cells are indeed able to efficiently repair DSBs induced by chlorine ions and protons that represent fragmentation products of Fe. Interestingly, activation of the tumor suppressor p53 in Fe-irradiated cells is uniquely biphasic and culminates in the induction of high levels of p21 (Waf1/Cip1), p16 (INK4a) and senescence-associated β-galactosidase activity. Surprisingly, these events occur even in the absence of ATM kinase implying that ATR may be a major responder to the complex DNA damage inflicted by Fe ions. Significantly, fragmentation of the Fe beam through PE attenuates these responses and this, in turn, results in better long-term survival in a colony-forming assay. Our results help us to understand the biological consequences of ion fragmentation through materials, whether in space or in the clinic, and provide us with a biological basis for the use of hydrogenous materials like PE as effective space shields.

We present measurements and model calculations of fluence and linear energy transfer in water ( LET ∞ ) obtained using 56 Fe beams with 1 GeV/amu kinetic energy incident on aluminum, polyethylene, PMMA, and lead targets. The measured spectra are compared to predictions of the PHITS model. The study is motivated by NASA's need to develop accurate heavy ion transport codes to assess radiation exposures in deep space, where galactic cosmic rays are important. The data were obtained at the Alternating Gradient Synchrotron at the Brookhaven National Laboratory. Distributions of charge and LET depend on the depth and composition of the target. Several of the targets studied are “thick”, defined operationally as a depth that presents at least 50% of an interaction length to the beam ions. In a thick target, the probability of a secondary interaction is significant, tertiary interactions can also be important, and the target-exit fluence and charge distributions depend on unmeasured cross sections that can only be estimated by nuclear interaction models. Comparisons between calculated and measured spectra are therefore of considerable interest. Some targets used in the study are thin, so that secondary and higher interaction probabilities are negligible, allowing more stringent comparisons between the data and the model. We find that PHITS reproduces some aspects of the experimental data well, but fails to accurately reproduce many of the measured fragment fluences.

Surface elevation and roughness measurements from NASA's Ice, Cloud, and land Elevation Satellite (ICESat) are compared with high-resolution airborne laser altimeter measurements over the Arctic sea ice north of Alaska, which were taken during the March 2006 EOS Aqua Advanced Microwave Scanning Radiometer sea ice validation campaign. The comparison of the elevation measurements shows that they agree quite well with correlations of around 0.9 for individual shots and a bias of less than 2 cm. The differences are found to decrease quite rapidly when applying running means. The comparison of the roughness measurements show that there are significant differences between the two data sets, with ICESat generally having higher values. The roughness values are only moderately correlated on an individual-shot basis, but applying running means to the data significantly improves the correlations to as high as 0.9. For the conversion of the elevation measurements into snow-ice freeboard, ocean surface elevation estimates are made with the high-resolution laser altimeter data, as well as several methods using lower resolution ICESat data. Under optimum conditions, i.e., when leads that are larger than the ICESat footprint are present, the ICESat- and Airborne Topographic Mapper-derived freeboards are found to agree to within 2 cm. For other areas, ICESat tends to underestimate the freeboard by up to 9 cm.

Projectile total and partial charge-changing cross sections have been measured for argon ions at 400 MeV/nucleon in carbon, aluminum, copper, tin and lead targets; cross sections for hydrogen were also obtained using a polyethylene target. The validity of weak and strong factorization properties has been investigated for partial charge-changing cross sections; measurements obtained for carbon, neon and silicon beams at 290 and 400 MeV/nucleon and iron beam at 400 MeV/nucleon, in carbon, aluminum, copper, tin and lead targets have also been used for the test. Two different analysis methods were applied and both indicated that these properties are valid, without any significant difference between weak and strong factorization. The factorization parameters have then been calculated and analyzed in order to find some systematic behavior useful for modeling purposes. (C) 2007 Elsevier B.V. All rights reserved.

We have collected from the literature partial charge-changing cross sections for projectiles with charge 6

In planning for long-duration spaceflight, it will beimportant to accurately model the exposure of astronauts to heavy ions inthe Galactic Cosmic Rays (GCR). As part of an ongoing effort to improveheavy-ion transport codes that will be used in designing futurespacecraft and habitats, fragmentation cross sections of 28Si have beenmeasured using beams with extracted energies from 290A MeV to 1200A MeV,spanning most of the peak region of the energy distribution of siliconions in the GCR. Results were obtained for six elemental targets:hydrogen, carbon, aluminum, copper, tin, and lead. The charge-changingcross sections are found to be energy-independent within the experimentaluncertainties, except for those on the hydrogen target. Cross sectionsfor the heaviest fragments are found to decrease slightly with increasingenergy for lighter targets, but increase with energy for tin and leadtargets. The cross sections are compared to previous measurements atsimilar energies, and to predictions of the NUCFRG2 model used by NASA toevaluate radiation exposures in flight. For charge-changing crosssections, reasonable agreement is found between the present experimentand those of Webber, et al. and Flesch, et al., and NUCFRG2 agrees withthe data to within 3 percent in most cases. Fragment cross sections showless agreement between experiments, and there are substantial differencesbetween NUCFRG2 predictions andthe data.

The PHITS (Particle and Heavy Ion Transport System) code is a three-dimensional Monte Carlo code that is able to simulate the transport of nuclei and other particles in complicated geometries and calculate fluxes, doses, energy-deposition distributions and many other observables. Among its many possible fields of application, it can be used e.g. to design and optimise radiation shields for space vessels. However, the reliability of the predictions of the code depends directly on the certified accuracy of the code components, i.e. the models the code uses to estimate the quantities necessary for the transport calculation. As a part of a comprehensive benchmarking program, we have investigated the possibility of using PHITS to calculate partial charge-changing cross sections and we have compared the results with measurements performed by some of us (CZ, LH, JM, SG). The results, although limited, suggest that the current reaction-cross-section models might be inadequate for use in space radioprotection; we therefore claim the need for a thorough benchmarking of the models and for new reaction-cross-section measurements and experimental techniques.

The design of future spacecraft such as the Crew Exploration Vehicle must take into account the radiation shielding properties of both the structural components as well as dedicated shielding materials. Since modest depths of shielding stop the vast majority of Solar Energetic Particles (SEP), the greater challenge is posed by the need to shield the crew from the Galactic Cosmic Rays (GCR), which include highly-charged and highly-energetic particles. Here, we report on results from tests performed with beams of 1 GeV/nuc 56 Fe at the Brookhaven National Laboratory. A wide variety of targets, both elemental and composite, was placed in the particle beams, and the spectra of particles emerging from the targets were measured using a stack of silicon detectors. Results are presented primarily in terms of dose reduction per g cm −2 of target material, and support the conclusions of an earlier calculation by Wilson et al. showing that performance improves as the shield’s mass number decreases, with hydrogen being by far the most effective shielding material. The data also show that, as depth increases, the incremental benefit of adding shielding decreases.

Measurements using silicon detectors to characterize the radiation transmitted through the EMU space suit and a human phantom have been performed using 155 and 250 MeV proton beams at LLUMC. The beams simulate radiation encountered in space, where trapped protons having kinetic energies on the order of 100 MeV are copious. Protons with 100 MeV kinetic energy and above can penetrate many centimeters of water or other light materials, so that astronauts exposed to such energetic particles will receive doses to their internal organs. This dose can be enhanced or reduced by shielding - either from the space suit or the self-shielding of the body - but minimization of the risk depends on details of the incident particle flux (in particular the energy spectrum) and on the dose responses of the various critical organs. Data were taken to characterize the beams and to calibrate the detectors using the beam in a treatment room at LLUPTF, in preparation for an experiment with the same beams incident on detectors placed in a human phantom within the EMU suit. Nuclear interactions of high-energy protons in various materials produce a small flux of highly ionizing, low-energy secondary radiation. Secondaries are of interest for their biological effects, since they cause doses and especially dose-equivalents to increase relative to the values expected simply from ionization energy loss along the Bragg curve. Because many secondaries have very short ranges, they are best measured in passive track detectors such as CR-39. The silicon detector data presented here are intended to supplement the CR-39 data in regions where silicon has greater sensitivity, in particular the portion of the LET spectrum below 5 keV/micron. The results obtained in this study suggest that optimizing the radiation shielding properties of space suits is a formidable task. The naive assumption that adding mass can reduce risk is not supported by the data, which show that reducing the dose delivered at or near the skin by low-energy particles may increase the dose delivered by energetic particles to points deeper in the body.

A tissue-equivalent proportional counter (TEPC) has been used as a dosimeter in mixed radiation fields. Since it does not measure LET directly, the response function must be characterized in order to estimate quality factor and thus equivalent dose for the incident radiation. The objectives of this study were to measure the response of a spherical TEPC for different high-energy heavy ions (HZE) having similar velocity and to determine how quality factors can be determined. Data were obtained at the HIMAC heavy ion accelerator for 4He and 12C at 220 ± 5 MeV / nucleon ( β = 0.59 ) and 12C, 16O, 28Si and 56Fe at 376 ± 15 MeV / nucleon ( β = 0.70 ) . A particle spectrometer recorded the charge and position of each incident beam particle. Events with low energy deposition were observed for particles that passed through the wall of the TEPC but not through the sensitive volume. The frequency averaged lineal energy, y ¯ f , was always less than the LET of the incident particles. The dose averaged lineal energy, y ¯ D , was approximately equal to LET for particles with LET greater than 10 keV/ μ m, whereas y ¯ D was larger than LET for the lighter particles with lower LET. Part of this effect is due to detector resolution and energy straggling that increases the variance of the response function. Although the TEPC is not a LET spectrometer, it can provide real time measurements of dose and provide estimates of quality factors for HZE particles using averaged values of lineal energy.

We report results for chromosomal aberrations in human peripheral blood lymphocytes after they were exposed to high-energy iron ions with or without shielding at the HIMAC, AGS and NSRL accelerators. Isolated lymphocytes were exposed to iron ions with energies between 200 and 5000 MeV/nucleon in the 0.1-1-Gy dose range. Shielding materials consisted of polyethylene, lucite (PMMA), carbon, aluminum and lead, with mass thickness ranging from 2 to 30 g/cm(2). After exposure, lymphocytes were stimulated to grow in vitro, and chromosomes were prematurely condensed using a phosphatase inhibitor (calyculin A). Aberrations were scored using FISH painting. The yield of total interchromosomal exchanges (including dicentrics, translocations and complex rearrangements) increased linearly with dose or fluence in the range studied. Shielding decreased the effectiveness per unit dose of iron ions. The highest RBE value was measured with the 1 GeV/nucleon iron-ion beam at NSRL. However, the RBE for the induction of aberrations apparently is not well correlated with the mean LET. When shielding thickness was increased, the frequency of aberrations per particle incident on the shield increased for the 500 MeV/nucleon ions and decreased for the 1 GeV/nucleon ions. Maximum variation at equal mass thickness was obtained with light materials (polyethylene, carbon or PMMA). Variations in the yield of chromosomal aberrations per iron particle incident on the shield follow variations in the dose per incident particle behind the shield but can be modified by the different RBE of the mixed radiation field produced by nuclear fragmentation. The results suggest that shielding design models should be benchmarked using both physics and biological data.

The ALTEA project investigates the risks of functional brain damage induced by particle radiation in space. A modular facility (the ALTEA facility) is being implemented and will be operated in the International Space Station (ISS) to record electrophysiological and behavioral descriptors of brain function and to monitor their time dynamics and correlation with particles and space environment. The focus of the program will be on abnormal visual perceptions (often reported as "light flashes" by astronauts) and the impact on retinal and brain visual structures of particle in microgravity conditions. The facility will be made available to the international scientific community for human neurophysiological, electrophysiological and psychophysics experiments, studies on particle fluxes, and dosimetry. A precursor of ALTEA (the 'Alteino' project) helps set the experimental baseline for the ALTEA experiments, while providing novel information on the radiation environment onboard the ISS and on the brain electrophysiology of the astronauts during orbital flights. Alteino was flown to the ISS on the Soyuz TM34 as part of mission Marco Polo. Controlled ground experiments using mice and accelerator beams complete the experimental strategy of ALTEA. We present here the status of progress of the ALTEA project and preliminary results of the Alteino study on brain dynamics, particle fluxes and abnormal visual perceptions. c2004 COSPAR. Published by Elsevier Ltd. All rights reserved.

ALTEA-MICE will supplement the ALTEA project on astronauts and provide information on the functional visual impairment possibly induced by heavy ions during prolonged operations in microgravity. Goals of ALTEA-MICE are: (1) to investigate the effects of heavy ions on the visual system of normal and mutant mice with retinal defects; (2) to define reliable experimental conditions for space research; and (3) to develop animal models to study the physiological consequences of space travels on humans. Remotely controlled mouse setup, applied electrophysiological recording methods, remote particle monitoring, and experimental procedures were developed and tested. The project has proved feasible under laboratory-controlled conditions comparable in important aspects to those of astronauts' exposure to particle in space. Experiments are performed at the Brookhaven National Laboratories [BNL] (Upton, NY, USA) and the Gesellschaft fur Schwerionenforschung mbH [GSI]/Biophysik (Darmstadt, FRG) to identify possible electrophysiological changes and/or activation of protective mechanisms in response to pulsed radiation. Offline data analyses are in progress and observations are still anecdotal. Electrophysiological changes after pulsed radiation are within the limits of spontaneous variability under anesthesia, with only indirect evidence of possible retinal/cortical responses. Immunostaining showed changes (e.g. increased expression of FGF2 protein in the outer nuclear layer) suggesting a retinal stress reaction to high-energy particles of potential relevance in space. c2004 COSPAR. Published by Elsevier Ltd. All rights reserved.

We describe the characterization of the B-type procyanidins in wine and the B-type dehydrodicatechins (dimeric flavan-3-ols) obtained for the autoxidation of (+)-catechin and (-)-epicatechin by tandem mass spectrometry (MS/MS) coupled to reversed-phase high-performance liquid chromatography (HPLC). The MS/MS analysis demonstrates that the interesting major fragments derive from the dissociations of the C-ring on the catechin or epicatechin unit, such as retro-Diels-Alder reactions. The two kinds of dimers give completely different fragmentations because of the striking effect of the C-C interflavan linkage (IFL). For the natural dimers in wine, a catechin or epicatechin unit linking to the C-4 position stabilizes the product ions by forming a large pi-pi hyperconjugated system, whereas a similar pi-pi system is formed within dehydrodicatechin B through the C-C IFL. Thus dissociation in MS/MS experiments was inhibited. Apparently, the fragmentations of the dimers differ from that of the monomer, which is very important in the study of the gas-phase ion behaviour of the polymeric flavan-3-ols. In addition, two specific fragment ions at m/z 451 for native dimers and at m/z 393 for autoxidation species in HPLC/MS/MS were found to be very useful for analysing mixtures of B-type procyanidins and B-type dehydrodicatechins in food and beverages.

The radiation environment on board the space shuttle and the International Space Station includes high-Z and high-energy (HZE) particles that are part of the galactic cosmic radiation (GCR) spectrum. Iron-56 particles are considered to be one of the most biologically important parts of the GCR spectrum. Tissue-equivalent proportional counters (TEPCs) are used as active dosimeters on manned space flights. These TEPCs are further used to determine the average quality factor for each space mission. A TEPC simulating a 1-microm-diameter sphere of tissue was exposed as part of a particle spectrometer to (56)Fe particles at energies from 200-1000 MeV/nucleon. The response of TEPCs in terms of mean lineal energy, y(F), and dose mean lineal energy, y(D), as well as the energy deposited at different impact parameters through the detector was determined for six different incident energies of (56)Fe particles in this energy range. Calculations determined that charged-particle equilibrium was achieved for each of the six experiments. Energy depositions at different impact parameters were calculated using a radial dose distribution model, and the results were compared to experimental data.

Deep-space manned flight as a reality depends on a viable solution to the radiation problem. Both acute and chronic radiation health threats are known to exist, with solar particle events as an example of the former and galactic cosmic rays (GCR) of the latter. In this experiment Iron ions of 1A GeV are used to simulate GCR and to determine the secondary radiation field created as the GCR-like particles interact with a thick target. A NASA prepared food pantry locker was subjected to the iron beam and the secondary fluence recorded. A modified version of the Monte Carlo heavy ion transport code developed by Zeitlin at LBNL is compared with experimental fluence. The foodstuff is modeled as mixed nuts as defined by the 71st edition of the Chemical Rubber Company (CRC) Handbook of Physics and Chemistry. The results indicate a good agreement between the experimental data and the model. The agreement between model and experiment is determined using a linear fit to ordered pairs of data. The intercept is forced to zero. The slope fit is 0.825 and the R2 value is 0.429 over the resolved fluence region. The removal of an outlier, Z=14, gives values of 0.888 and 0.705 for slope and R2 respectively.