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6. Humanized Transgenic Mice Are Resistant to Chronic Wasting Disease Prions From Norwegian Reindeer and Moose.

Author

Wadsworth, Jonathan D F, Joiner, Susan, Linehan, Jacqueline M, Jack, Kezia, Al-Doujaily, Huda, Costa, Helena, Ingold, Thea, Taema, Maged, Zhang, Fuquan, Sandberg, Malin K, Brandner, Sebastian, Tran, Linh, Vikøren, Turid, Våge, Jørn, Madslien, Knut, Ytrehus, Bjørnar, Benestad, Sylvie L, Asante, Emmanuel A, and Collinge, John

Subjects
MAMMAL metabolism, PRIONS, ANIMAL experimentation, RESEARCH funding, MICE
Abstract

Chronic wasting disease (CWD) is the transmissible spongiform encephalopathy or prion disease affecting cervids. In 2016, the first cases of CWD were reported in Europe in Norwegian wild reindeer and moose. The origin and zoonotic potential of these new prion isolates remain unknown. In this study to investigate zoonotic potential we inoculated brain tissue from CWD-infected Norwegian reindeer and moose into transgenic mice overexpressing human prion protein. After prolonged postinoculation survival periods no evidence for prion transmission was seen, suggesting that the zoonotic potential of these isolates is low. [ABSTRACT FROM AUTHOR]

Published
2022
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7. Humanized Transgenic Mice Are Resistant to Chronic Wasting Disease Prions From Norwegian Reindeer and Moose

Author

Wadsworth, Jonathan D F, primary, Joiner, Susan, additional, Linehan, Jacqueline M, additional, Jack, Kezia, additional, Al-Doujaily, Huda, additional, Costa, Helena, additional, Ingold, Thea, additional, Taema, Maged, additional, Zhang, Fuquan, additional, Sandberg, Malin K, additional, Brandner, Sebastian, additional, Tran, Linh, additional, Vikøren, Turid, additional, Våge, Jørn, additional, Madslien, Knut, additional, Ytrehus, Bjørnar, additional, Benestad, Sylvie L, additional, Asante, Emmanuel A, additional, and Collinge, John, additional

Published
2021
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8. GROWING UP CHRISTIAN.

Author

Jack, Kezia

Subjects
CHRISTIANS
Abstract

The article profiles Kezia Jack as she grew up as a Christian.

Published
2012

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