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X-ray images are vital in medical diagnostics, but their effectiveness is limited without clinical context. Radiologists often find chest X-rays insufficient for diagnosing underlying diseases, necessitating comprehensive clinical features and data integration. We present a novel framework to enhance the clinical context through augmentation techniques with clinical tabular data, thereby improving its applicability and reliability in AI medical diagnostics. We introduce a pioneering approach to clinical data augmentation that employs large language models to generate patient contextual synthetic data. This methodology is crucial for training more robust deep learning models in healthcare. It preserves the integrity of real patient data while enriching the dataset with contextually relevant synthetic features, significantly enhancing model performance. Our methodology, termed DALL-M, uses a three-phase feature generation process: (i)clinical context storage, (ii)expert query generation, and (iii)context-aware feature augmentation. DALL-M generates new, clinically relevant features by synthesizing chest X-ray images and reports. Applied to 799 cases using nine features from the MIMIC-IV dataset, it created an augmented set of 91 features. This is the first work to generate contextual values for patients' X-ray reports. Specifically, we provide (i)the capacity of LLMs to generate contextual synthetic values for existing clinical features and (ii)their ability to create entirely new clinically relevant features. Empirical validation with machine learning models showed significant performance improvements. Incorporating augmented features increased the F1 score by 16.5% and Precision and Recall by approximately 25%. DALL-M addresses a critical gap in clinical data augmentation, offering a robust framework for generating contextually enriched datasets., Comment: we introduce a pioneering approach to clinical data augmentation that employs large language models (LLMs) to generate patient contextual synthetic data. It preserves the integrity of real patient data while enriching the dataset with contextually relevant synthetic features, significantly enhancing model performance

We present, for the first time, a novel theoretical approach to address the problem of correspondence free multivector cloud registration in conformal geometric algebra. Such formalism achieves several favorable properties. Primarily, it forms an orthogonal automorphism that extends beyond the typical vector space to the entire conformal geometric algebra while respecting the multivector grading. Concretely, the registration can be viewed as an orthogonal transformation (\it i.e., scale, translation, rotation) belonging to $SO(4,1)$ - group of special orthogonal transformations in conformal geometric algebra. We will show that such formalism is able to: $(i)$ perform the registration without directly accessing the input multivectors. Instead, we use primitives or geometric objects provided by the conformal model - the multivectors, $(ii)$ the geometric objects are obtained by solving a multilinear eigenvalue problem to find sets of eigenmultivectors. In this way, we can explicitly avoid solving the correspondences in the registration process. Most importantly, this offers rotation and translation equivariant properties between the input multivectors and the eigenmultivectors. Experimental evaluation is conducted in datasets commonly used in point cloud registration, to testify the usefulness of the approach with emphasis to ambiguities arising from high levels of noise. The code is available at https://github.com/Numerical-Geometric-Algebra/RegistrationGA . This work was submitted to the International Journal of Computer Vision and is currently under review.

Depth maps produced by consumer-grade sensors suffer from inaccurate measurements and missing data from either system or scene-specific sources. Data-driven denoising algorithms can mitigate such problems. However, they require vast amounts of ground truth depth data. Recent research has tackled this limitation using self-supervised learning techniques, but it requires multiple RGB-D sensors. Moreover, most existing approaches focus on denoising single isolated depth maps or specific subjects of interest, highlighting a need for methods to effectively denoise depth maps in real-time dynamic environments. This paper extends state-of-the-art approaches for depth-denoising commodity depth devices, proposing SelfReDepth, a self-supervised deep learning technique for depth restoration, via denoising and hole-filling by inpainting full-depth maps captured with RGB-D sensors. The algorithm targets depth data in video streams, utilizing multiple sequential depth frames coupled with color data to achieve high-quality depth videos with temporal coherence. Finally, SelfReDepth is designed to be compatible with various RGB-D sensors and usable in real-time scenarios as a pre-processing step before applying other depth-dependent algorithms. Our results demonstrate our approach's real-time performance on real-world datasets. They show that it outperforms state-of-the-art denoising and restoration performance at over 30fps on Commercial Depth Cameras, with potential benefits for augmented and mixed-reality applications., Comment: 13pp, 5 figures, 1 table

Deep learning models have revolutionized the field of medical image analysis, due to their outstanding performances. However, they are sensitive to spurious correlations, often taking advantage of dataset bias to improve results for in-domain data, but jeopardizing their generalization capabilities. In this paper, we propose to limit the amount of information these models use to reach the final classification, by using a multiple instance learning (MIL) framework. MIL forces the model to use only a (small) subset of patches in the image, identifying discriminative regions. This mimics the clinical procedures, where medical decisions are based on localized findings. We evaluate our framework on two medical applications: skin cancer diagnosis using dermoscopy and breast cancer diagnosis using mammography. Our results show that using only a subset of the patches does not compromise diagnostic performance for in-domain data, compared to the baseline approaches. However, our approach is more robust to shifts in patient demographics, while also providing more detailed explanations about which regions contributed to the decision. Code is available at: https://github.com/diogojpa99/MedicalMultiple-Instance-Learning., Comment: Accepted in DEF-AI-MIA Workshop@CVPR 2024

Head pose estimation has become a crucial area of research in computer vision given its usefulness in a wide range of applications, including robotics, surveillance, or driver attention monitoring. One of the most difficult challenges in this field is managing head occlusions that frequently take place in real-world scenarios. In this paper, we propose a novel and efficient framework that is robust in real world head occlusion scenarios. In particular, we propose an unsupervised latent embedding clustering with regression and classification components for each pose angle. The model optimizes latent feature representations for occluded and non-occluded images through a clustering term while improving fine-grained angle predictions. Experimental evaluation on in-the-wild head pose benchmark datasets reveal competitive performance in comparison to state-of-the-art methodologies with the advantage of having a significant data reduction. We observe a substantial improvement in occluded head pose estimation. Also, an ablation study is conducted to ascertain the impact of the clustering term within our proposed framework., Comment: Accepted at 18th IEEE International Conference on Automatic Face and Gesture Recognition (FG'24)

Head orientation is a challenging Computer Vision problem that has been extensively researched having a wide variety of applications. However, current state-of-the-art systems still underperform in the presence of occlusions and are unreliable for many task applications in such scenarios. This work proposes a novel deep learning approach for the problem of head pose estimation under occlusions. The strategy is based on latent space regression as a fundamental key to better structure the problem for occluded scenarios. Our model surpasses several state-of-the-art methodologies for occluded HPE, and achieves similar accuracy for non-occluded scenarios. We demonstrate the usefulness of the proposed approach with: (i) two synthetically occluded versions of the BIWI and AFLW2000 datasets, (ii) real-life occlusions of the Pandora dataset, and (iii) a real-life application to human-robot interaction scenarios where face occlusions often occur. Specifically, the autonomous feeding from a robotic arm.

This study investigates the effects of including patients' clinical information on the performance of deep learning (DL) classifiers for disease location in chest X-ray images. Although current classifiers achieve high performance using chest X-ray images alone, our interviews with radiologists indicate that clinical data is highly informative and essential for interpreting images and making proper diagnoses. In this work, we propose a novel architecture consisting of two fusion methods that enable the model to simultaneously process patients' clinical data (structured data) and chest X-rays (image data). Since these data modalities are in different dimensional spaces, we propose a spatial arrangement strategy, spatialization, to facilitate the multimodal learning process in a Mask R-CNN model. We performed an extensive experimental evaluation using MIMIC-Eye, a dataset comprising modalities: MIMIC-CXR (chest X-ray images), MIMIC IV-ED (patients' clinical data), and REFLACX (annotations of disease locations in chest X-rays). Results show that incorporating patients' clinical data in a DL model together with the proposed fusion methods improves the disease localization in chest X-rays by 12\% in terms of Average Precision compared to a standard Mask R-CNN using only chest X-rays. Further ablation studies also emphasize the importance of multimodal DL architectures and the incorporation of patients' clinical data in disease localization. The architecture proposed in this work is publicly available to promote the scientific reproducibility of our study (https://github.com/ChihchengHsieh/multimodal-abnormalities-detection)

Survival time prediction from medical images is important for treatment planning, where accurate estimations can improve healthcare quality. One issue affecting the training of survival models is censored data. Most of the current survival prediction approaches are based on Cox models that can deal with censored data, but their application scope is limited because they output a hazard function instead of a survival time. On the other hand, methods that predict survival time usually ignore censored data, resulting in an under-utilization of the training set. In this work, we propose a new training method that predicts survival time using all censored and uncensored data. We propose to treat censored data as samples with a lower-bound time to death and estimate pseudo labels to semi-supervise a censor-aware survival time regressor. We evaluate our method on pathology and x-ray images from the TCGA-GM and NLST datasets. Our results establish the state-of-the-art survival prediction accuracy on both datasets., Comment: 12 pages, 4 figures

Overall survival (OS) time prediction is one of the most common estimates of the prognosis of gliomas and is used to design an appropriate treatment planning. State-of-the-art (SOTA) methods for OS time prediction follow a pre-hoc approach that require computing the segmentation map of the glioma tumor sub-regions (necrotic, edema tumor, enhancing tumor) for estimating OS time. However, the training of the segmentation methods require ground truth segmentation labels which are tedious and expensive to obtain. Given that most of the large-scale data sets available from hospitals are unlikely to contain such precise segmentation, those SOTA methods have limited applicability. In this paper, we introduce a new post-hoc method for OS time prediction that does not require segmentation map annotation for training. Our model uses medical image and patient demographics (represented by age) as inputs to estimate the OS time and to estimate a saliency map that localizes the tumor as a way to explain the OS time prediction in a post-hoc manner. It is worth emphasizing that although our model can localize tumors, it uses only the ground truth OS time as training signal, i.e., no segmentation labels are needed. We evaluate our post-hoc method on the Multimodal Brain Tumor Segmentation Challenge (BraTS) 2019 data set and show that it achieves competitive results compared to pre-hoc methods with the advantage of not requiring segmentation labels for training., Comment: 5 pages, 2 figure

The deployment of automated systems to diagnose diseases from medical images is challenged by the requirement to localise the diagnosed diseases to justify or explain the classification decision. This requirement is hard to fulfil because most of the training sets available to develop these systems only contain global annotations, making the localisation of diseases a weakly supervised approach. The main methods designed for weakly supervised disease classification and localisation rely on saliency or attention maps that are not specifically trained for localisation, or on region proposals that can not be refined to produce accurate detections. In this paper, we introduce a new model that combines region proposal and saliency detection to overcome both limitations for weakly supervised disease classification and localisation. Using the ChestX-ray14 data set, we show that our proposed model establishes the new state-of-the-art for weakly-supervised disease diagnosis and localisation., Comment: Early accept at MICCAI 2020

Meta-training has been empirically demonstrated to be the most effective pre-training method for few-shot learning of medical image classifiers (i.e., classifiers modeled with small training sets). However, the effectiveness of meta-training relies on the availability of a reasonable number of hand-designed classification tasks, which are costly to obtain, and consequently rarely available. In this paper, we propose a new method to unsupervisedly design a large number of classification tasks to meta-train medical image classifiers. We evaluate our method on a breast dynamically contrast enhanced magnetic resonance imaging (DCE-MRI) data set that has been used to benchmark few-shot training methods of medical image classifiers. Our results show that the proposed unsupervised task design to meta-train medical image classifiers builds a pre-trained model that, after fine-tuning, produces better classification results than other unsupervised and supervised pre-training methods, and competitive results with respect to meta-training that relies on hand-designed classification tasks.

We present 3DRegNet, a novel deep learning architecture for the registration of 3D scans. Given a set of 3D point correspondences, we build a deep neural network to address the following two challenges: (i) classification of the point correspondences into inliers/outliers, and (ii) regression of the motion parameters that align the scans into a common reference frame. With regard to regression, we present two alternative approaches: (i) a Deep Neural Network (DNN) registration and (ii) a Procrustes approach using SVD to estimate the transformation. Our correspondence-based approach achieves a higher speedup compared to competing baselines. We further propose the use of a refinement network, which consists of a smaller 3DRegNet as a refinement to improve the accuracy of the registration. Extensive experiments on two challenging datasets demonstrate that we outperform other methods and achieve state-of-the-art results. The code is available., Comment: 15 pages, 8 figures, 6 tables

Pedestrian detection is one of the most explored topics in computer vision and robotics. The use of deep learning methods allowed the development of new and highly competitive algorithms. Deep Reinforcement Learning has proved to be within the state-of-the-art in terms of both detection in perspective cameras and robotics applications. However, for detection in omnidirectional cameras, the literature is still scarce, mostly because of their high levels of distortion. This paper presents a novel and efficient technique for robust pedestrian detection in omnidirectional images. The proposed method uses deep Reinforcement Learning that takes advantage of the distortion in the image. By considering the 3D bounding boxes and their distorted projections into the image, our method is able to provide the pedestrian's position in the world, in contrast to the image positions provided by most state-of-the-art methods for perspective cameras. Our method avoids the need of pre-processing steps to remove the distortion, which is computationally expensive. Beyond the novel solution, our method compares favorably with the state-of-the-art methodologies that do not consider the underlying distortion for the detection task., Comment: Accepted in 2019 IEEE Int'l Conf. Robotics and Automation (ICRA)

We propose a new method for breast cancer screening from DCE-MRI based on a post-hoc approach that is trained using weakly annotated data (i.e., labels are available only at the image level without any lesion delineation). Our proposed post-hoc method automatically diagnosis the whole volume and, for positive cases, it localizes the malignant lesions that led to such diagnosis. Conversely, traditional approaches follow a pre-hoc approach that initially localises suspicious areas that are subsequently classified to establish the breast malignancy -- this approach is trained using strongly annotated data (i.e., it needs a delineation and classification of all lesions in an image). Another goal of this paper is to establish the advantages and disadvantages of both approaches when applied to breast screening from DCE-MRI. Relying on experiments on a breast DCE-MRI dataset that contains scans of 117 patients, our results show that the post-hoc method is more accurate for diagnosing the whole volume per patient, achieving an AUC of 0.91, while the pre-hoc method achieves an AUC of 0.81. However, the performance for localising the malignant lesions remains challenging for the post-hoc method due to the weakly labelled dataset employed during training., Comment: Submitted to Medical Image Analysis

The training of medical image analysis systems using machine learning approaches follows a common script: collect and annotate a large dataset, train the classifier on the training set, and test it on a hold-out test set. This process bears no direct resemblance with radiologist training, which is based on solving a series of tasks of increasing difficulty, where each task involves the use of significantly smaller datasets than those used in machine learning. In this paper, we propose a novel training approach inspired by how radiologists are trained. In particular, we explore the use of meta-training that models a classifier based on a series of tasks. Tasks are selected using teacher-student curriculum learning, where each task consists of simple classification problems containing small training sets. We hypothesize that our proposed meta-training approach can be used to pre-train medical image analysis models. This hypothesis is tested on the automatic breast screening classification from DCE-MRI trained with weakly labeled datasets. The classification performance achieved by our approach is shown to be the best in the field for that application, compared to state of art baseline approaches: DenseNet, multiple instance learning and multi-task learning., Comment: Oral Presentation at MICCAI 2018

A real-time Deep Learning based method for Pedestrian Detection (PD) is applied to the Human-Aware robot navigation problem. The pedestrian detector combines the Aggregate Channel Features (ACF) detector with a deep Convolutional Neural Network (CNN) in order to obtain fast and accurate performance. Our solution is firstly evaluated using a set of real images taken from onboard and offboard cameras and, then, it is validated in a typical robot navigation environment with pedestrians (two distinct experiments are conducted). The results on both tests show that our pedestrian detector is robust and fast enough to be used on robot navigation applications.

This paper addresses the problem of Human-Aware Navigation (HAN), using multi camera sensors to implement a vision-based person tracking system. The main contributions of this paper are as follows: a novel and efficient Deep Learning person detection and a standardization of human-aware constraints. In the first stage of the approach, we propose to cascade the Aggregate Channel Features (ACF) detector with a deep Convolutional Neural Network (CNN) to achieve fast and accurate Pedestrian Detection (PD). Regarding the human awareness (that can be defined as constraints associated with the robot's motion), we use a mixture of asymmetric Gaussian functions, to define the cost functions associated to each constraint. Both methods proposed herein are evaluated individually to measure the impact of each of the components. The final solution (including both the proposed pedestrian detection and the human-aware constraints) is tested in a typical domestic indoor scenario, in four distinct experiments. The results show that the robot is able to cope with human-aware constraints, defined after common proxemics and social rules., Comment: Accepted in Robotics and Autonomous Systems