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2. Upcoming and urgent challenges in critical care research based on COVID-19 pandemic experience

Author

Verdonk, Franck, Feyaerts, Dorien, Badenes, Rafael, Bastarache, Julie A, Bouglé, Adrien, Ely, Wesley, Gaudilliere, Brice, Howard, Christopher, Kotfis, Katarzyna, Lautrette, Alexandre, Le Dorze, Matthieu, Mankidy, Babith Joseph, Matthay, Michael A, Morgan, Christopher K, Mazeraud, Aurélien, Patel, Brijesh V, Pattnaik, Rajyabardhan, Reuter, Jean, Schultz, Marcus J, Sharshar, Tarek, Shrestha, Gentle S, Verdonk, Charles, Ware, Lorraine B, Pirracchio, Romain, and Jabaudon, Matthieu

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Health and social care services research, 8.1 Organisation and delivery of services, Generic health relevance, Good Health and Well Being, Artificial Intelligence, COVID-19, Critical Care, Delivery of Health Care, Humans, Pandemics, Critical care, Research, Pandemic, Perspectives, Clinical sciences
Abstract

While the coronavirus disease 2019 (COVID-19) pandemic placed a heavy burden on healthcare systems worldwide, it also induced urgent mobilisation of research teams to develop treatments preventing or curing the disease and its consequences. It has, therefore, challenged critical care research to rapidly focus on specific fields while forcing critical care physicians to make difficult ethical decisions. This narrative review aims to summarise critical care research -from organisation to research fields- in this pandemic setting and to highlight opportunities to improve research efficiency in the future, based on what is learned from COVID-19. This pressure on research revealed, i.e., (i) the need to harmonise regulatory processes between countries, allowing simplified organisation of international research networks to improve their efficiency in answering large-scale questions; (ii) the importance of developing translational research from which therapeutic innovations can emerge; (iii) the need for improved triage and predictive scores to rationalise admission to the intensive care unit. In this context, key areas for future critical care research and better pandemic preparedness are artificial intelligence applied to healthcare, characterisation of long-term symptoms, and ethical considerations. Such collaborative research efforts should involve groups from both high and low-to-middle income countries to propose worldwide solutions. As a conclusion, stress tests on healthcare organisations should be viewed as opportunities to design new research frameworks and strategies. Worldwide availability of research networks ready to operate is essential to be prepared for next pandemics. Importantly, researchers and physicians should prioritise realistic and ethical goals for both clinical care and research.

Published
2022

7. Thoracic epidural analgesia in intensive care unit patients with acute pancreatitis: the EPIPAN multicenter randomized controlled trial

Author

Jabaudon, Matthieu, Genevrier, Alexandra, Jaber, Samir, Windisch, Olivier, Bulyez, Stéphanie, Laterre, Pierre-François, Escudier, Etienne, Sossou, Achille, Guerci, Philippe, Bertrand, Pierre-Marie, Danin, Pierre-Eric, Bonnassieux, Martin, Bühler, Leo, Heidegger, Claudia Paula, Chabanne, Russell, Godet, Thomas, Roszyk, Laurence, Sapin, Vincent, Futier, Emmanuel, Pereira, Bruno, and Constantin, Jean-Michel

Published
2023
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9. Safety and Efficacy of Mini-Invasive Left Atrial Appendage Closure: A Propensity-Score Analysis

Author

Denis, Catherine, Clerfond, Guillaume, Chalard, Aurélie, Riocreux, Clément, Pereira, Bruno, Lamallem, Ouarda, Guizani, Taieb, Catalan, Pierre-Antoine, Boudias, Antoine, Jean, Frédéric, Bouchant-Pioche, Marion, Abu-Alrub, Saer, Combaret, Nicolas, Souteyrand, Géraud, Motreff, Pascal, Jabaudon, Matthieu, Futier, Emmanuel, Massoullie, Grégoire, and Eschalier, Romain

Published
2024
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10. Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis

Author

Carla, Adrien, Pereira, Bruno, Boukail, Hanifa, Audard, Jules, Pinol-Domenech, Nathalie, De Carvalho, Manuela, Blondonnet, Raiko, Zhai, Ruoyang, Morand, Dominique, Lambert, Céline, Sapin, Vincent, Ware, Lorraine B, Calfee, Carolyn S, Bastarache, Julie A, Laffey, John G, Juffermans, Nicole P, Bos, Lieuwe D, Artigas, Antonio, Rocco, Patricia RM, Matthay, Michael A, McAuley, Daniel F, Constantin, Jean-Michel, and Jabaudon, Matthieu

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Rare Diseases, Acute Respiratory Distress Syndrome, Respiratory, Adrenergic beta-Agonists, Animals, Disease Models, Animal, Humans, Phenotype, Positive-Pressure Respiration, Randomized Controlled Trials as Topic, Respiratory Distress Syndrome, Treatment Outcome, Systematic review protocol, Acute respiratory distress syndrome, Preclinical, Subphenotypes, ESICM Translational Biology Group of the Acute Respiratory Failure section, Cardiorespiratory Medicine and Haematology, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundSubphenotypes were recently reported within clinical acute respiratory distress syndrome (ARDS), with distinct outcomes and therapeutic responses. Experimental models have long been used to mimic features of ARDS pathophysiology, but the presence of distinct subphenotypes among preclinical ARDS remains unknown. This review will investigate whether: 1) subphenotypes can be identified among preclinical ARDS models; 2) such subphenotypes can identify some responsive traits.MethodsWe will include comparative preclinical (in vivo and ex vivo) ARDS studies published between 2009 and 2019 in which pre-specified therapies were assessed (interleukin (IL)-10, IL-2, stem cells, beta-agonists, corticosteroids, fibroblast growth factors, modulators of the receptor for advanced glycation end-products pathway, anticoagulants, and halogenated agents) and outcomes compared to a control condition. The primary outcome will be a composite of the four key features of preclinical ARDS as per the American Thoracic Society consensus conference (histologic evidence of lung injury, altered alveolar-capillary barrier, lung inflammatory response, and physiological dysfunction). Secondary outcomes will include the single components of the primary composite outcome, net alveolar fluid clearance, and death. MEDLINE, Embase, and Cochrane databases will be searched electronically and data from eligible studies will be extracted, pooled, and analyzed using random-effects models. Individual study reporting will be assessed according to the Animal Research: Reporting of In Vivo Experiments guidelines. Meta-regressions will be performed to identify subphenotypes prior to comparing outcomes across subphenotypes and treatment effects.DiscussionThis study will inform on the presence and underlying pathophysiological features of subphenotypes among preclinical models of ARDS and should help to determine whether sufficient evidence exists to perform preclinical trials of subphenotype-targeted therapies, prior to potential clinical translation.Systematic review registrationPROSPERO (ID: CRD42019157236).

Published
2020

11. Effect of non-invasive ventilation after extubation in critically ill patients with obesity in France: a multicentre, unblinded, pragmatic randomised clinical trial

Author

DE JONG, AUDREY, BIGNON, ANNE, STEPHAN, FRANÇOIS, GODET, THOMAS, CONSTANTIN, JEAN-MICHEL, ASEHNOUNE, KARIM, SYLVESTRE, AUDE, SAUTILLET, JULIETTE, BLONDONNET, RAIKO, FERRANDIERE, MARTINE, SEGUIN, PHILIPPE, LASOCKI, SIGISMOND, ROLLE, AMELIE, FAYOLLE, PIERRE-MARIE, MULLER, LAURENT, PARDO, EMMANUEL, TERZI, NICOLAS, RAMIN, SEVERIN, JUNG, BORIS, ABBACK, PAER-SELIM, GUERCI, PHILIPPE, SARTON, BENJAMINE, ROZE, HADRIEN, DUPUIS, CLAIRE, COUSSON, JOEL, FAUCHER, MARION, LEMIALE, VIRGINIE, CHOLLEY, BERNARD, CHANQUES, GERALD, BELAFIA, FOUAD, HUGUET, HELENA, FUTIER, EMMANUEL, GNIADEK, CLAUDINE, VONARB, AURELIE, PRADES, ALBERT, JAILLET, CARINE, CAPDEVILA, XAVIER, CHARBIT, JONATHAN, GENTY, THIBAUT, REZAIGUIA-DELCLAUX, SAIDA, IMBERT, AUDREY, PILORGE, CATHERINE, CALYPSO, ROMAN, BOUTEAU-DURAND, ASTRID, CARLES, MICHEL, MEHDAOUI, HOSSEN, SOUWEINE, BERTRAND, CALVET, LAURE, JABAUDON, MATTHIEU, RIEU, BENJAMIN, CANDILLE, CLARA, SIGAUD, FLORIAN, RIU, BEATRICE, PAPAZIAN, LAURENT, VALERA, SABINE, MOKART, DJAMEL, CHOW CHINE, LAURENT, BISBAL, MAGALI, POULIQUEN, CAMILLE, DE GUIBERT, JEAN-MANUEL, TOURRET, MAXIME, MALLET, DAMIEN, LEONE, MARC, ZIELESKIEWICZ, LAURENT, COSSIC, JEANNE, ASSEFI, MONA, BARON, ELODIE, QUEMENEUR, CYRIL, MONSEL, ANTOINE, BIAIS, MATTHIEU, OUATTARA, ALEXANDRE, BONNARDEL, ELINE, MONZIOLS, SIMON, MAHUL, MARTIN, LEFRANT, JEAN-YVES, ROGER, CLAIRE, BARBAR, SABER, LAMBIOTTE, FABIEN, SAINT-LEGER, PIEHR, PAUGAM, CATHERINE, POTTECHER, JULIEN, LUDES, PIERRE-OLIVIER, DARRIVERE, LUCIE, GARNIER, MARC, KIPNIS, ERIC, LEBUFFE, GILLES, GAROT, MATTHIAS, FALCONE, JEREMY, CHOUSTERMAN, BENJAMIN, COLLET, MAGALI, GAYAT, ETIENNE, DELLAMONICA, JEAN, MFAM, WILLY-SERGE, OCHIN, EVELINA, NEBLI, MOHAMED, TILOUCHE, NEJLA, MADEUX, BENJAMIN, BOUGON, DAVID, AARAB, YASSIR, GARNIER, FANNY, AZOULAY, ELIE, MOLINARI, NICOLAS, JABER, SAMIR, De Jong, Audrey, Bignon, Anne, Stephan, François, Godet, Thomas, Constantin, Jean-Michel, Asehnoune, Karim, Sylvestre, Aude, Sautillet, Juliette, Blondonnet, Raiko, Ferrandière, Martine, Seguin, Philippe, Lasocki, Sigismond, Rollé, Amélie, Fayolle, Pierre-Marie, Muller, Laurent, Pardo, Emmanuel, Terzi, Nicolas, Ramin, Séverin, Jung, Boris, Abback, Paer-Selim, Guerci, Philippe, Sarton, Benjamine, Rozé, Hadrien, Dupuis, Claire, Cousson, Joel, Faucher, Marion, Lemiale, Virginie, Cholley, Bernard, Chanques, Gerald, Belafia, Fouad, Huguet, Helena, Futier, Emmanuel, Azoulay, Elie, Molinari, Nicolas, and Jaber, Samir

Published
2023
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13. Pancréatite aiguë grave du patient adulte en soins critiques 2021

Author

Jaber, Samir, Garnier, Marc, Asehnoune, Karim, Bounes, Fanny, Buscail, Louis, Chevaux, Jean-Baptiste, Dahyot-Fizelier, Claire, Darrivere, Lucie, Jabaudon, Matthieu, Joannes-Boyau, Olivier, Launey, Yoann, Levesque, Eric, Levy, Philippe, Montravers, Philippe, Muller, Laurent, Rimmelé, Thomas, Roger, Claire, Savoye-Collet, Céline, Seguin, Philippe, Tasu, Jean-Pierre, Thibault, Ronan, Vanbiervliet, Geoffroy, Weiss, Emmanuel, and Jong, Audrey de

Published
2022
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15. Guidelines for the management of patients with severe acute pancreatitis, 2021

Author

Jaber, Samir, Garnier, Marc, Asehnoune, Karim, Bounes, Fanny, Buscail, Louis, Chevaux, Jean-Baptiste, Dahyot-Fizelier, Claire, Darrivere, Lucie, Jabaudon, Matthieu, Joannes-Boyau, Olivier, Launey, Yoann, Levesque, Eric, Levy, Philippe, Montravers, Philippe, Muller, Laurent, Rimmelé, Thomas, Roger, Claire, Savoye-Collet, Céline, Seguin, Philippe, Tasu, Jean-Pierre, Thibault, Ronan, Vanbiervliet, Geoffroy, Weiss, Emmanuel, and De Jong, Audrey

Published
2022
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22. Potential Value of the Radiographic Assessment of Lung Edema (RALE) Score to Assess Resolution of Pulmonary Edema in a Clinical Trial in Acute Respiratory Distress Syndrome (ARDS)

Author

Jabaudon, Matthieu, primary, Warren, Melissa A., additional, Koyama, Tatsuki, additional, Lavin, Philip, additional, Javitt, Jonathan C., additional, Morganroth, Melvin L., additional, Korczykowski, Marc, additional, Hollingsworth, John W., additional, Lee, Richard A., additional, Youssef, Jihad G., additional, and Ware, Lorraine B., additional

Published
2024
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25. Ex Vivo Optimization of Donor Lungs with Inhaled Sevoflurane during Normothermic Ex Vivo Lung Perfusion (VITALISE): A Pilot and Feasibility Study in Sheep

Author

Steinkühler, Timo, primary, Yang, Shuqi, additional, Hu, Michiel A., additional, Jainandunsing, Jayant S., additional, Jager, Neeltina M., additional, Erasmus, Michiel E., additional, Struys, Michel M. R. F., additional, Bosch, Dirk J., additional, van Meurs, Matijs, additional, Jabaudon, Matthieu, additional, Richard, Damien, additional, Timens, Wim, additional, Leuvenink, Henri G. D., additional, and Nieuwenhuijs-Moeke, Gertrude J., additional

Published
2024
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26. Physiological effects and safety of bed verticalization in patients with acute respiratory distress syndrome

Author

BOUCHANT, Louis, primary, GODET, Thomas, additional, ARPAJOU, Gauthier, additional, AUPETITGENDRE, Lucie, additional, CAYOT, Sophie, additional, GUERIN, Renaud, additional, JABAUDON, Matthieu, additional, VERLHAC, Camille, additional, BLONDONNET, Raiko, additional, BORAO, Lucile, additional, PEREIRA, Bruno, additional, CONSTANTIN, Jean-Michel, additional, BAZIN, Jean-Etienne, additional, FUTIER, Emmanuel, additional, and AUDARD, Jules, additional

Published
2024
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28. Analgesia and sedation in patients with ARDS

Author

Chanques, Gerald, Constantin, Jean-Michel, Devlin, John W., Ely, E. Wesley, Fraser, Gilles L., Gélinas, Céline, Girard, Timothy D., Guérin, Claude, Jabaudon, Matthieu, Jaber, Samir, Mehta, Sangeeta, Langer, Thomas, Murray, Michael J., Pandharipande, Pratik, Patel, Bhakti, Payen, Jean-François, Puntillo, Kathleen, Rochwerg, Bram, Shehabi, Yahya, Strøm, Thomas, Olsen, Hanne Tanghus, and Kress, John P.

Published
2020
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30. Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory pressure for patients with acute respiratory distress syndrome in France (the LIVE study): a multicentre, single-blind, randomised controlled trial

Author

Sophie, Cayot, Thomas, Godet, Renaud, Guerin, Camille, Verlac, Russel, Chabanne, Bernard, Cosserant, Raiko, Blondonnet, Alexandre, Lautrette, Nathanael, Eisenmann, Laurent, Muller, Pablo, Massanet, Caroline, Boutin, Saber, Barbar, Claire, Roger, Fouad, Belafia, Moussa, Cisse, Marion, Monnin, Matthieu, Conseil, Julie, Carr, Audrey, De Jong, Auguste, Dargent, Pascal, Andreu, Thomas, Lebouvrier, Yoann, Launey, Antoine, Roquilly, Raphael, Cinotti, Anne-Charlotte, Tellier, Mathilde, Barbaz, Benjamin, Cohen, Edouard, Lemarche, Pierre-Marie, Bertrand, Charlotte, Arberlot, Laurent, Zieleskiewicz, Emmanuelle, Hammad, Garry, Duclos, Calypso, Mathie, Herve, Dupont, Benoit, Veber, Jean-Christophe, Orban, Hervé, Quintard, Thomas, Rimmele, Julien, Crozon-Clauzel, Marinne, Le Core, Fabien, Grelon, Mona, Assefi, Frank, Petitas, Jerome, Morel, Serge, Molliex, Nanadougmar, Hadanou, Constantin, Jean-Michel, Jabaudon, Matthieu, Lefrant, Jean-Yves, Jaber, Samir, Quenot, Jean-Pierre, Langeron, Olivier, Ferrandière, Martine, Grelon, Fabien, Seguin, Philippe, Ichai, Carole, Veber, Benoit, Souweine, Bertrand, Uberti, Thomas, Lasocki, Sigismond, Legay, François, Leone, Marc, Eisenmann, Nathanael, Dahyot-Fizelier, Claire, Dupont, Hervé, Asehnoune, Karim, Sossou, Achille, Chanques, Gérald, Muller, Laurent, Bazin, Jean-Etienne, Monsel, Antoine, Borao, Lucile, Garcier, Jean-Marc, Rouby, Jean-Jacques, Pereira, Bruno, and Futier, Emmanuel

Published
2019
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35. Decision support system to evaluate VENTilation in the Acute Respiratory Distress Syndrome

Author

Patel, Brijesh V, primary, Mumby, Sharon, additional, Johnson, Nicholas, additional, Falaschetti, Emanuela, additional, Handslip, Rhodri, additional, Patel, Sunil, additional, Lee, Teresa, additional, Andersen, Martin S, additional, Adcock, Ian, additional, McAuley, Danny F, additional, Takata, Masao, additional, Staudinger, Thomas, additional, Karbing, Dan S, additional, Jabaudon, Matthieu, additional, Schellongowski, Peter, additional, and Rees, Stephen E, additional

Published
2023
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42. Immediate interruption of sedation compared with usual sedation care in critically ill postoperative patients (SOS-Ventilation): a randomised, parallel-group clinical trial

Author

Chanques, Gerald, Conseil, Matthieu, Prades, Albert, Carr, Julie, Jung, Boris, Belafia, Fouad, Cissé, Moussa, Delay, Jean-Marc, De Jong, Audrey, Verzilli, Daniel, Clavieras, Noémie, Jaber, Samir, Mercier, Grégoire, Molinari, Nicolas, Mathieu, Emmanuelle, Bertet, Héléna, Roger, Claire, Muller, Laurent, Lefrant, Jean-Yves, Boutin, Caroline, Constantin, Jean-Michel, Futier, Emmanuel, Cayot, Sophie, Perbet, Sébastien, Jabaudon, Matthieu, and de Jong, Audrey

Published
2017
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43. Epidural analgesia in ICU chest trauma patients with fractured ribs: retrospective study of pain control and intubation requirements

Author

Bachoumas, Konstantinos, Levrat, Albrice, Le Thuaut, Aurélie, Rouleau, Stéphane, Groyer, Samuel, Dupont, Hervé, Rooze, Paul, Eisenmann, Nathanael, Trampont, Timothée, Bohé, Julien, Rieu, Benjamin, Chakarian, Jean-Charles, Godard, Aurélie, Frederici, Laura, Gélinotte, Stephanie, Joret, Aurélie, Roques, Pascale, Painvin, Benoit, Leroy, Christophe, Benedit, Marcel, Dopeux, Loic, Soum, Edouard, Botoc, Vlad, Fartoukh, Muriel, Hausermann, Marie-Hélène, Kamel, Toufik, Morin, Jean, De Varax, Roland, Plantefève, Gaetan, Herbland, Alexandre, Jabaudon, Matthieu, Duburcq, Thibault, Simon, Christelle, Chabanne, Russell, Schneider, Francis, Ganster, Frederique, Bruel, Cedric, Laggoune, Ahmed-Saïd, Bregeaud, Delphine, Souweine, Bertrand, Reignier, Jean, and Lascarrou, Jean-Baptiste

Published
2020
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45. Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data

Author

Jabaudon, Matthieu, Blondonnet, Raiko, Pereira, Bruno, Cartin-Ceba, Rodrigo, Lichtenstern, Christoph, Mauri, Tommaso, and Determann, Rogier M.

Subjects
Mortality -- France -- United Kingdom, Mediation, Acute respiratory distress syndrome -- Patient outcomes, Health care industry
Abstract

Purpose The soluble receptor for advanced glycation end-products (sRAGE) is a marker of lung epithelial injury and alveolar fluid clearance (AFC), with promising values for assessing prognosis and lung injury severity in acute respiratory distress syndrome (ARDS). Because AFC is impaired in most patients with ARDS and is associated with higher mortality, we hypothesized that baseline plasma sRAGE would predict mortality, independently of two key mediators of ventilator-induced lung injury. Methods We conducted a meta-analysis of individual data from 746 patients enrolled in eight prospective randomized and observational studies in which plasma sRAGE was measured in ARDS articles published through March 2016. The primary outcome was 90-day mortality. Using multivariate and mediation analyses, we tested the association between baseline plasma sRAGE and mortality, independently of driving pressure and tidal volume. Results Higher baseline plasma sRAGE [odds ratio (OR) for each one-log increment, 1.18; 95% confidence interval (CI) 1.01-1.38; P = 0.04], driving pressure (OR for each one-point increment, 1.04; 95% CI 1.02-1.07; P = 0.002), and tidal volume (OR for each one-log increment, 1.98; 95% CI 1.07-3.64; P = 0.03) were independently associated with higher 90-day mortality in multivariate analysis. Baseline plasma sRAGE mediated a small fraction of the effect of higher [DELTA]P on mortality but not that of higher V.sub.T. Conclusions Higher baseline plasma sRAGE was associated with higher 90-day mortality in patients with ARDS, independently of driving pressure and tidal volume, thus reinforcing the likely contribution of alveolar epithelial injury as an important prognostic factor in ARDS. Registration: PROSPERO (ID: CRD42018100241)., Author(s): Matthieu Jabaudon [sup.1] [sup.2], Raiko Blondonnet [sup.1] [sup.2], Bruno Pereira [sup.3], Rodrigo Cartin-Ceba [sup.4], Christoph Lichtenstern [sup.5], Tommaso Mauri [sup.6], Rogier M. Determann [sup.7], Tomas Drabek [sup.8], Rolf D. [...]

Published
2018
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46. Impact of storage temperature and time before analysis on electrolytes (Na+, K+, Ca2+), lactate, glucose, blood gases (pH, pO2, pCO2), tHb, O2Hb, COHb and MetHb results

Author

Puravet, Antoine, primary, Rieu, Benjamin, additional, Phere, Camille, additional, Kahouadji, Samy, additional, Pereira, Bruno, additional, Jabaudon, Matthieu, additional, Andanson, Benjamin, additional, Brailova, Marina, additional, Sapin, Vincent, additional, and Bouvier, Damien, additional

Published
2023
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47. Elevated Plasma Levels of sRAGE Are Associated With Nonfocal CT-Based Lung Imaging in Patients With ARDS: A Prospective Multicenter Study

Author

Mrozek, Segolene, Jabaudon, Matthieu, Jaber, Samir, Paugam-Burtz, Catherine, Lefrant, Jean-Yves, Rouby, Jean-Jacques, Asehnoune, Karim, Allaouchiche, Bernard, Baldesi, Olivier, Leone, Marc, Lu, Qin, Bazin, Jean-Etienne, Roszyk, Laurence, Sapin, Vincent, Futier, Emmanuel, Pereira, Bruno, and Constantin, Jean-Michel

Published
2016
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50. Impact of storage temperature and time before analysis on electrolytes (Na+, K+, Ca2+), lactate, glucose, blood gases (pH, pO2, pCO2), tHb, O2Hb, COHb and MetHb results.

Author

Puravet, Antoine, Rieu, Benjamin, Phere, Camille, Kahouadji, Samy, Pereira, Bruno, Jabaudon, Matthieu, Andanson, Benjamin, Brailova, Marina, Sapin, Vincent, and Bouvier, Damien

Subjects
ELECTROLYTE analysis, CARBOXYHEMOGLOBIN, BLOOD gases analysis, BLOOD gases, LACTATES, LACTATION, OXYGEN carriers, GLUCOSE
Abstract

The objective of our study is to evaluate the effect of storage temperature and time to analysis on arterial blood gas parameters in order to extend the CLSI recommendations. Stability of 12 parameters (pH, pCO₂, pO₂, Na+, K+, Ca2+, glucose, lactate, hemoglobin, oxyhemoglobin, carboxyhemoglobin, methemoglobin) measured by GEM PREMIER™ 5000 blood gas analyzer was studied at room temperature and at +4 °C (52 patients). The storage times were 30, 45, 60, 90 and 120 min. Stability was evaluated on the difference from baseline, the difference from the analyte-specific measurement uncertainty applied to the baseline value, and the impact of the variation on the clinical interpretation. At room temperature, all parameters except the lactate remained stable for at least 60 min. A statistically significant difference was observed for pH at T45 and T60 and for pCO2 at T60 without modification of clinical interpretation. For lactate, clinical interpretation was modified from T45 and values were outside the range of acceptability defined by the measurement uncertainty. All parameters except pO2 remained stable for at least 120 min at +4 °C. A one-hour transport at room temperature is compatible with the performance of all the analyses studied except lactate. If the delay exceeds 30 min, the sample should be placed at +4 °C for lactate measurement. If the samples are stored in ice, it is important to note that the pO2 cannot be interpreted. [ABSTRACT FROM AUTHOR]

Published
2023
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