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105 results on '"Jaako P"'

1. METTL3/MYCN cooperation drives neural crest differentiation and provides therapeutic vulnerability in neuroblastoma

Author

Thombare, Ketan, Vaid, Roshan, Pucci, Perla, Ihrmark Lundberg, Kristina, Ayyalusamy, Ritish, Baig, Mohammad Hassan, Mendez, Akram, Burgos-Panadero, Rebeca, Höppner, Stefanie, Bartenhagen, Christoph, Sjövall, Daniel, Rehan, Aqsa Ali, Dattatraya Nale, Sagar, Djos, Anna, Martinsson, Tommy, Jaako, Pekka, Dong, Jae-June, Kogner, Per, Johnsen, John Inge, Fischer, Matthias, Turner, Suzanne D, and Mondal, Tanmoy

Published
2024
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2. Quantum computing with superconducting circuits in the picosecond regime

Author

Zhu, Daoquan, Jaako, Tuomas, He, Qiongyi, and Rabl, Peter

Subjects
Quantum Physics
Abstract

We discuss the realization of a universal set of ultrafast single- and two-qubit operations with superconducting quantum circuits and investigate the most relevant physical and technical limitations that arise when pushing for faster and faster gates. With the help of numerical optimization techniques, we establish a fundamental bound on the minimal gate time, which is determined independently of the qubit design solely by its nonlinearity. In addition, important practical restrictions arise from the finite qubit transition frequency and the limited bandwidth of the control pulses. We show that for highly anharmonic flux qubits and commercially available control electronics, elementary single- and two-qubit operations can be implemented in about 100 picoseconds with residual gate errors below $10^{-4}$. Under the same conditions, we simulate the complete execution of a compressed version of Shor's algorithm for factoring the number 15 in about one nanosecond. These results demonstrate that compared to state-of-the-art implementations with transmon qubits, a hundredfold increase in the speed of gate operations with superconducting circuits is still feasible., Comment: 16 pages, 13 figures

Published
2021
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4. Super-correlated radiance in nonlinear photonic waveguides

Author

Wang, Zhihai, Jaako, Tuomas, Kirton, Peter, and Rabl, Peter

Subjects
Quantum Physics, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We study the collective decay of two-level emitters coupled to a nonlinear waveguide, for example, a nanophotonic lattice or a superconducting resonator array with strong photon-photon interactions. Under these conditions a new decay channel into bound photon pairs emerges, through which spatial correlations between emitters are established by regular interference as well as interactions between the photons. We derive an effective Markovian theory to model the resulting decay dynamics of an arbitrary distribution of emitters and identify collective effects beyond the usual phenomena of super- and subradiance. Specifically, in the limit of many close-by emitters, we find that the system undergoes a super-correlated decay process where either all the emitters are in the excited state or in the ground state, but not in any of the intermediate states. The predicted effects can be probed in state-of-the-art waveguide QED experiments and provide a striking example of how the dynamics of open quantum systems can be modified by many-body effects in a non-harmonic environment., Comment: 6+13 pages 4+7 figures, more details are discussed

Published
2019
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5. Quantum Simulation of Non-perturbative Cavity QED with Trapped Ions

Author

Jaako, Tuomas, Garcia-Ripoll, Juan José, and Rabl, Peter

Subjects
Quantum Physics, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We discuss the simulation of non-perturbative cavity-QED effects using systems of trapped ions. Specifically, we address the implementation of extended Dicke models with both collective dipole-field and direct dipole-dipole interactions, which represent a minimal set of models for describing light-matter interactions in the ultrastrong and deep-strong coupling regime. We show that this approach can be used in state-of-the-art trapped ion setups to investigate excitation spectra or the transition between sub- and superradiant ground states, which are currently not accessible in any other physical system. Our analysis also reveals the intrinsic difficulty of accessing this non-perturbative regime with larger numbers of dipoles, which makes the simulation of many-dipole cavity QED a particularly challenging test case for future quantum simulation platforms., Comment: 10 pages, 5 figures

Published
2019
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6. Ultrastrong coupling circuit QED in the radio-frequency regime

Author

Jaako, T., Garcia-Ripoll, J. J., and Rabl, P.

Subjects
Quantum Physics, Condensed Matter - Superconductivity
Abstract

We study a circuit QED setup where multiple superconducting qubits are ultrastrongly coupled to a single radio-frequency resonator. In this extreme parameter regime of cavity QED the dynamics of the electromagnetic mode is very slow compared to all other relevant timescales and can be described as an effective particle moving in an adiabatic energy landscape defined by the qubits. The focus of this work is placed on settings with two or multiple qubits, where different types of symmetry-breaking transitions in the ground- and excited-state potentials can occur. Specifically, we show how the change in the level structure and the wave packet dynamics associated with these transition points can be probed via conventional excitation spectra and Ramsey measurements performed at GHz frequencies. More generally, this analysis demonstrates that state-of-the-art circuit QED systems can be used to access a whole range of particle-like quantum mechanical phenomena beyond the usual paradigm of coupled qubits and oscillators., Comment: 14 pages, 7 figures

Published
2019
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7. Breakdown of gauge invariance in ultrastrong-coupling cavity QED

Author

De Bernardis, Daniele, Pilar, Philipp, Jaako, Tuomas, De Liberato, Simone, and Rabl, Peter

Subjects
Quantum Physics, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We revisit the derivation of Rabi- and Dicke-type models, which are commonly used for the study of quantum light-matter interactions in cavity and circuit QED. We demonstrate that the validity of the two-level approximation, which is an essential step in this derivation, depends explicitly on the choice of gauge once the system enters the ultrastrong coupling regime. In particular, while in the electric dipole gauge the two-level approximation can be performed as long as the Rabi frequency remains much smaller than the energies of all higher-lying levels, it can dramatically fail in the Coulomb gauge, even for systems with an extremely anharmonic spectrum. We extensively investigate this phenomenon both in the single-dipole (Rabi) and multi-dipole (Dicke) case, and considering the specific examples of dipoles confined by double-well and by square-well potentials, and of circuit QED systems with flux qubits coupled to an LC resonator., Comment: See also related independent work arxiv:1805.06356

Published
2018
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8. Cavity quantum electrodynamics in the non-perturbative regime

Author

De Bernardis, Daniele, Jaako, Tuomas, and Rabl, Peter

Subjects
Quantum Physics, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We study a generic cavity-QED system where a set of (artificial) two-level dipoles is coupled to the electric field of a single-mode LC resonator. This setup is used to derive a minimal quantum mechanical model for cavity QED, which accounts for both dipole-field and direct dipole-dipole interactions. The model is applicable for arbitrary coupling strengths and allows us to extend the usual Dicke model into the non-perturbative regime of QED, where the dipole-field interaction can be associated with an effective finestructure constant of order unity. In this regime, we identify three distinct classes of normal, superradiant and subradiant vacuum states and discuss their characteristic properties and the transitions between them. Our findings reconcile many of the previous, often contradictory predictions in this field and establish a common theoretical framework to describe ultrastrong coupling phenomena in a diverse range of cavity-QED platforms.

Published
2017
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9. Harvesting Multiqubit Entanglement from Ultrastrong Interactions in Circuit Quantum Electrodynamics

Author

Armata, Federico, Calajo, Giuseppe, Jaako, Tuomas, Kim, M. S., and Rabl, Peter

Subjects
Quantum Physics, Condensed Matter - Superconductivity
Abstract

We analyze a multiqubit circuit QED system in the regime where the qubit-photon coupling dominates over the system's bare energy scales. Under such conditions a manifold of low-energy states with a high degree of entanglement emerges. Here we describe a time-dependent protocol for extracting these quantum correlations and converting them into well-defined multipartite entangled states of noninteracting qubits. Based on a combination of various ultrastrong-coupling effects, the protocol can be operated in a fast and robust manner, while still being consistent with experimental constraints on switching times and typical energy scales encountered in superconducting circuits. Therefore, our scheme can serve as a probe for otherwise inaccessible correlations in strongly coupled circuit QED systems. It also shows how such correlations can potentially be exploited as a resource for entanglement-based applications., Comment: 14 pages, 10 figures

Published
2017
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12. Ultrastrong coupling phenomena beyond the Dicke model

Author

Jaako, Tuomas, Xiang, Ze-Liang, Garcia-Ripoll, Juan José, and Rabl, Peter

Subjects
Quantum Physics, Condensed Matter - Superconductivity
Abstract

We study effective light-matter interactions in a circuit QED system consisting of a single $LC$ resonator, which is coupled symmetrically to multiple superconducting qubits. Starting from a minimal circuit model, we demonstrate that in addition to the usual collective qubit-photon coupling the resulting Hamiltonian contains direct qubit-qubit interactions, which have a drastic effect on the ground and excited state properties of such circuits in the ultrastrong coupling regime. In contrast to a superradiant phase transition expected from the standard Dicke model, we find an opposite mechanism, which at very strong interactions completely decouples the photon mode and projects the qubits into a highly entangled ground state. These findings resolve previous controversies over the existence of superradiant phases in circuit QED, but they more generally show that the physics of two- or multi-atom cavity QED settings can differ significantly from what is commonly assumed., Comment: 11 pages, 8 figures

Published
2016
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13. Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

Author

Harris, William S., Tintle, Nathan L., Imamura, Fumiaki, Qian, Frank, Korat, Andres V. Ardisson, Marklund, Matti, Djoussé, Luc, Bassett, Julie K., Carmichael, Pierre-Hugues, Chen, Yun-Yu, Hirakawa, Yoichiro, Küpers, Leanne K., Laguzzi, Federica, Lankinen, Maria, Murphy, Rachel A., Samieri, Cécilia, Senn, Mackenzie K., Shi, Peilin, Virtanen, Jyrki K., Brouwer, Ingeborg A., Chien, Kuo-Liong, Eiriksdottir, Gudny, Forouhi, Nita G., Geleijnse, Johanna M., Giles, Graham G., Gudnason, Vilmundur, Helmer, Catherine, Hodge, Allison, Jackson, Rebecca, Khaw, Kay-Tee, Laakso, Markku, Lai, Heidi, Laurin, Danielle, Leander, Karin, Lindsay, Joan, Micha, Renata, Mursu, Jaako, Ninomiya, Toshiharu, Post, Wendy, Psaty, Bruce M., Risérus, Ulf, Robinson, Jennifer G., Shadyab, Aladdin H., Snetselaar, Linda, Sala-Vila, Aleix, Sun, Yangbo, Steffen, Lyn M., Tsai, Michael Y., Wareham, Nicholas J., Wood, Alexis C., Wu, Jason H. Y., Hu, Frank, Sun, Qi, Siscovick, David S., Lemaitre, Rozenn N., and Mozaffarian, Dariush

Published
2021
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15. The effects of counseling via a smartphone application on microentrepreneurs’ work ability and work recovery: a study protocol

Author

Laitinen, J., Korkiakangas, E., Mäkiniemi, J. P., Tiitinen, S., Tikka, P., Oinas-Kukkonen, H., Simunaniemi, A. M., Ahola, S., Jaako, J., Kekkonen, M., Muhos, M., Heikkilä-Tammi, K., Hannonen, H., Lusa, S., Punakallio, A., Oksa, J., Mänttäri, S., Ilomäki, S., Logren, A., Verbeek, J., Ruotsalainen, J., Remes, J., Ruusuvuori, J., and Oksanen, T.

Published
2020
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16. A Triangular Approach to Integrate Research, Education and Practice in Higher Engineering Education

Author

Heikkinen, Eetu-Pekka, Jaako, Juha, and Hiltunen, Jukka

Abstract

Separate approaches in engineering education, research and practice are not very useful when preparing students for working life; instead, integration of education, research and industrial practices is needed. A triangular approach (TA) as a method to accomplish this integration and as a method to provide students with integrated expertise is proposed. The results from the application of TA, both at the course and programme level, indicate that the approach is suitable for developing engineering education. The student pass rate for courses where TA has been used has been higher than for previous approaches, and the student feedback has been very positive. Although TA aims to take both theoretical and practical aspects of engineering as well as research and education into account, the approach concentrates mainly on activities and therefore leaves the goals of these activities as well as the values behind these goals uncovered.

Published
2017
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17. Controlling the Didactic Relation: A Case in Process Engineering Education

Author

Jaako, Juha

Abstract

A case study was conducted during 1994-2013 on several groups of process engineering students to see what was needed to transform a single course from a teacher-centred to a student-centred learning environment (SCLE). Development work was done incrementally, using Herbart's didactic triangle as a theoretical framework. The effects of the changes in learning environment were analysed using quantitative (student attendance, pass rate, attrition, grades) and qualitative data (student feedback). Guiding the didactic relation, i.e. the studying done by students, by continuous assessment was found to be very useful. Using SCLEs that emphasise student responsibility and activity in learning has been found in this case to enhance student learning considerably.

Published
2014
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19. Pedagogical Basis of DAS Formalism in Engineering Education

Author

Hiltunen, J., Heikkinen, E.-P, Jaako, J., and Ahola, J.

Abstract

The paper presents a new approach for a bachelor-level curriculum structure in engineering. The approach is called DAS formalism according to its three phases: description, analysis and synthesis. Although developed specifically for process and environmental engineering, DAS formalism has a generic nature and it could also be used in other engineering fields. The motivation for this new curriculum structure originates from the urge to solve the problems that engineering education has faced during the past decades, e.g. student recruitment problems and dissatisfactory learning outcomes. The focus of this paper is on the structure of the curriculum but the content is also discussed when it has an effect on the structure and its implementation. The presented structure, i.e. DAS formalism, builds upon the ideas of some classical pedagogical theories, which have regularly been applied at course level but seldom used to solve curriculum-level issues. (Contains 2 tables and 1 figure.)

Published
2011
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24. Novel genetic susceptibility loci for diabetic end-stage renal disease identified through robust naive Bayes classification

Author

Sambo, Francesco, Malovini, Alberto, Sandholm, Niina, Stavarachi, Monica, Forsblom, Carol, Mäkinen, Ville-Petteri, Harjutsalo, Valma, Lithovius, Raija, Gordin, Daniel, Parkkonen, Maija, Saraheimo, Markku, Thorn, Lena M., Tolonen, Nina, Wadén, Johan, He, Bing, Österholm, Anne-May, Tuomilehto, Jaako, Lajer, Maria, Salem, Rany M., McKnight, Amy Jayne, Tarnow, Lise, Panduru, Nicolae M., Barbarini, Nicola, Di Camillo, Barbara, Toffolo, Gianna M., Tryggvason, Karl, Bellazzi, Riccardo, Cobelli, Claudio, Groop, Per-Henrik, The GENIE Consortium, and The FinnDiane Study Group

Published
2014
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26. Measurement of prompt J/ψ and beauty hadron production cross sections at mid-rapidity in pp collisions at $ \sqrt{s}=7 $ TeV

Author

Abelev, Betty, Adam, Jaroslav, Adamova, Dagmar, Adare, Andrew Marshall, Aggarwal, Madan, Rinella, Gianluca Aglieri, Agocs, Andras Gabor, Agostinelli, Andrea, Salazar, Saul Aguilar, Ahammed, Zubayer, Ahmad, Arshad, Ahmad, Nazeer, Ahn, Sul-Ah, Ahn, Sang Un, Akindinov, Alexander, Aleksandrov, Dmitry, Alessandro, Bruno, Molina, Jose Ruben Alfaro, Alici, Andrea, Alkin, Anton, Avina, Erick Jonathan Almaraz, Alme, Johan, Alt, Torsten, Altini, Valerio, Altinpinar, Sedat, Altsybeev, Igor, Andrei, Cristian, Andronic, Anton, Anguelov, Venelin, Anielski, Jonas, Anson, Christopher Daniel, Anticic, Tome, Antinori, Federico, Antonioli, Pietro, Aphecetche, Laurent Bernard, Appelshauser, Harald, Arbor, Nicolas, Arcelli, Silvia, Arend, Andreas, Armesto, Nestor, Arnaldi, Roberta, Aronsson, Tomas Robert, Arsene, Ionut Cristian, Arslandok, Mesut, Asryan, Andzhey, Augustinus, Andre, Averbeck, Ralf Peter, Awes, Terry, Aysto, Juha Heikki, Azmi, Mohd Danish, Bach, Matthias Jakob, Badala, Angela, Baek, Yong Wook, Bailhache, Raphaelle Marie, Bala, Renu, Ferroli, Rinaldo Baldini, Baldisseri, Alberto, Baldit, Alain, Dos Santos Pedrosa, Fernando Baltasar, Ban, Jaroslav, Baral, Rama Chandra, Barbera, Roberto, Barile, Francesco, Barnafoldi, Gergely Gabor, Barnby, Lee Stuart, Barret, Valerie, Bartke, Jerzy Gustaw, Basile, Maurizio, Bastid, Nicole, Basu, Sumit, Bathen, Bastian, Batigne, Guillaume, Batyunya, Boris, Baumann, Christoph Heinrich, Bearden, Ian Gardner, Beck, Hans, Behera, Nirbhay Kumar, Belikov, Iouri, Bellini, Francesca, Bellwied, Rene, Belmont-Moreno, Ernesto, Bencedi, Gyula, Beole, Stefania, Berceanu, Ionela, Bercuci, Alexandru, Berdnikov, Yaroslav, Berenyi, Daniel, Bergognon, Anais Annick Erica, Berzano, Dario, Betev, Latchezar, Bhasin, Anju, Bhati, Ashok Kumar, Bhom, Jihyun, Bianchi, Livio, Bianchi, Nicola, Bianchin, Chiara, Bielcik, Jaroslav, Bielcikova, Jana, Bilandzic, Ante, Bjelogrlic, Sandro, Blanco, F., Blanco, Francesco, Blau, Dmitry, Blume, Christoph, Boccioli, Marco, Bock, Nicolas, Boettger, Stefan, Bogdanov, Alexey, Boggild, Hans, Bogolyubsky, Mikhail, Boldizsar, Laszlo, Bombara, Marek, Book, Julian, Borel, Herve, Borissov, Alexander, Bose, Suvendu Nath, Bossu, Francesco, Botje, Michiel, Boyer, Bruno Alexandre, Braidot, Ermes, Braun-Munzinger, Peter, Bregant, Marco, Breitner, Timo Gunther, Browning, Tyler Allen, Broz, Michal, Brun, Rene, Bruna, Elena, Bruno, Giuseppe Eugenio, Budnikov, Dmitry, Buesching, Henner, Bufalino, Stefania, Bugaiev, Kyrylo, Busch, Oliver, Buthelezi, Edith Zinhle, Orduna, Diego Caballero, Caffarri, Davide, Cai, Xu, Caines, Helen Louise, Villar, Ernesto Calvo, Camerini, Paolo, Roman, Veronica Canoa, Romeo, Giovanni Cara, Carena, Francesco, Carena, Wisla, Filho, Nelson Carlin, Carminati, Federico, Montoya, Camilo Andres Carrillo, Diaz, Amaya Ofelia Casanova, Castellanos, Javier Ernesto Castillo, Hernandez, Juan Francisco Castillo, Casula, Ester Anna Rita, Catanescu, Vasile, Cavicchioli, Costanza, Sanchez, Cesar Ceballos, Cepila, Jan, Cerello, Piergiorgio, Chang, Beomsu, Chapeland, Sylvain, Charvet, Jean-Luc Fernand, Chattopadhyay, Subhasis, Chattopadhyay, Sukalyan, Chawla, Isha, Cherney, Michael Gerard, Cheshkov, Cvetan, Cheynis, Brigitte, Barroso, Vasco Miguel Chibante, Chinellato, David, Chochula, Peter, Chojnacki, Marek, Choudhury, Subikash, Christakoglou, Panagiotis, Christensen, Christian Holm, Christiansen, Peter, Chujo, Tatsuya, Chung, Suh-Urk, Cicalo, Corrado, Cifarelli, Luisa, Cindolo, Federico, Cleymans, Jean Willy Andre, Coccetti, Fabrizio, Colamaria, Fabio, Colella, Domenico, Balbastre, Gustavo Conesa, del Valle, Zaida Conesa, Constantin, Paul, Contin, Giacomo, Contreras, Jesus Guillermo, Cormier, Thomas Michael, Morales, Yasser Corrales, Cortese, Pietro, Maldonado, Ismael Cortes, Cosentino, Mauro Rogerio, Costa, Filippo, Cotallo, Manuel Enrique, Crescio, Elisabetta, Crochet, Philippe, Alaniz, Emilia Cruz, Cuautle, Eleazar, Cunqueiro, Leticia, Dainese, Andrea, Dalsgaard, Hans Hjersing, Danu, Andrea, Das, Debasish, Das, Indranil, Das, Kushal, Dash, Sadhana, Dash, Ajay Kumar, De, Sudipan, de Barros, Gabriel, De Caro, Annalisa, de Cataldo, Giacinto, de Cuveland, Jan, De Falco, Alessandro, De Gruttola, Daniele, Delagrange, Hugues, Deloff, Andrzej, Demanov, Vyacheslav, De Marco, Nora, Denes, Ervin, De Pasquale, Salvatore, Deppman, Airton, D’Erasmo, Ginevra, de Rooij, Raoul Stefan, Corchero, Miguel Angel Diaz, Di Bari, Domenico, Di Giglio, Carmelo, Dietel, Thomas, Di Liberto, Sergio, Di Mauro, Antonio, Di Nezza, Pasquale, Divia, Roberto, Djuvsland, Oeystein, Dobrin, Alexandru Florin, Dobrowolski, Tadeusz Antoni, Dominguez, Isabel, Donigus, Benjamin, Dordic, Olja, Driga, Olga, Dubey, Anand Kumar, Ducroux, Laurent, Dupieux, Pascal, Majumdar, Mihir Ranjan Dutta, Majumdar, A. K. Dutta, Elia, Domenico, Emschermann, David Philip, Engel, Heiko, Erdal, Hege Austrheim, Espagnon, Bruno, Estienne, Magali Danielle, Esumi, Shinichi, Evans, David, Eyyubova, Gyulnara, Fabris, Daniela, Faivre, Julien, Falchieri, Davide, Fantoni, Alessandra, Fasel, Markus, Fearick, Roger Worsley, Fedunov, Anatoly, Fehlker, Dominik, Feldkamp, Linus, Felea, Daniel, Fenton-Olsen, Bo, Feofilov, Grigory, Tellez, Arturo Fernandez, Ferretti, Alessandro, Ferretti, Roberta, Figiel, Jan, Figueredo, Marcel, Filchagin, Sergey, Finogeev, Dmitry, Fionda, Fiorella, Fiore, Enrichetta Maria, Floris, Michele, Foertsch, Siegfried Valentin, Foka, Panagiota, Fokin, Sergey, Fragiacomo, Enrico, Frankenfeld, Ulrich Michael, Fuchs, Ulrich, Furget, Christophe, Girard, Mario Fusco, Gaardhoje, Jens Joergen, Gagliardi, Martino, Gago, Alberto, Gallio, Mauro, Gangadharan, Dhevan Raja, Ganoti, Paraskevi, Garabatos, Jose, Garcia-Solis, Edmundo, Garishvili, Irakli, Gerhard, Jochen, Germain, Marie, Geuna, Claudio, Gheata, Andrei George, Gheata, Mihaela, Ghidini, Bruno, Ghosh, Premomoy, Gianotti, Paola, Girard, Martin Robert, Giubellino, Paolo, Gladysz-Dziadus, Ewa, Glassel, Peter, Gomez, Ramon, Gonschior, Alexey, Ferreiro, Elena Gonzalez, Gonzalez-Trueba, Laura Helena, Gonzalez-Zamora, Pedro, Gorbunov, Sergey, Goswami, Ankita, Gotovac, Sven, Grabski, Varlen, Graczykowski, Lukasz Kamil, Grajcarek, Robert, Grelli, Alessandro, Grigoras, Costin, Grigoras, Alina Gabriela, Grigoriev, Vladislav, Grigoryan, Ara, Grigoryan, Smbat, Grinyov, Boris, Grion, Nevio, Gros, Philippe, Grosse-Oetringhaus, Jan Fiete, Grossiord, Jean-Yves, Grosso, Raffaele, Guber, Fedor, Guernane, Rachid, Gutierrez, Cesar Guerra, Guerzoni, Barbara, Guilbaud, Maxime Rene Joseph, Gulbrandsen, Kristjan Herlache, Gunji, Taku, Gupta, Anik, Gupta, Ramni, Gutbrod, Hans, Haaland, Oystein Senneset, Hadjidakis, Cynthia Marie, Haiduc, Maria, Hamagaki, Hideki, Hamar, Gergoe, Han, Byounghee, Hanratty, Luke David, Hansen, Alexander, Harmanova, Zuzana, Harris, John William, Hartig, Matthias, Hasegan, Dumitru, Hatzifotiadou, Despoina, Hayrapetyan, Arsen, Heckel, Stefan Thomas, Heide, Markus Ansgar, Helstrup, Haavard, Herghelegiu, Andrei Ionut, Corral, Gerardo Antonio Herrera, Herrmann, Norbert, Hess, Benjamin Andreas, Hetland, Kristin Fanebust, Hicks, Bernard, Hille, Per Thomas, Hippolyte, Boris, Horaguchi, Takuma, Hori, Yasuto, Hristov, Peter Zahariev, Hrivnacova, Ivana, Huang, Meidana, Humanic, Thomas, Hwang, Dae Sung, Ichou, Raphaelle, Ilkaev, Radiy, Ilkiv, Iryna, Inaba, Motoi, Incani, Elisa, Innocenti, Gian Michele, Innocenti, Pier Giorgio, Ippolitov, Mikhail, Irfan, Muhammad, Ivan, Cristian George, Ivanov, Vladimir, Ivanov, Marian, Ivanov, Andrey, Ivanytskyi, Oleksii, Jacholkowski, Adam Wlodzimierz, Jacobs, Peter, Jang, Haeng Jin, Jangal, Swensy Gwladys, Janik, Malgorzata Anna, Janik, Rudolf, Jayarathna, Sandun, Jena, Satyajit, Jha, Deeptanshu Manu, Bustamante, Raul Tonatiuh Jimenez, Jirden, Lennart, Jones, Peter Graham, Jung, Hyung Taik, Jusko, Anton, Kaidalov, Alexei, Kakoyan, Vanik, Kalcher, Sebastian, Kalinak, Peter, Kalliokoski, Tuomo Esa Aukusti, Kalweit, Alexander Philipp, Kanaki, Kalliopi, Kang, Ju Hwan, Kaplin, Vladimir, Uysal, Ayben Karasu, Karavichev, Oleg, Karavicheva, Tatiana, Karpechev, Evgeny, Kazantsev, Andrey, Kebschull, Udo Wolfgang, Keidel, Ralf, Khan, Palash, Khan, Mohisin Mohammed, Khan, Shuaib Ahmad, Khanzadeev, Alexei, Kharlov, Yury, Kileng, Bjarte, Kim, Do Won, Kim, Mimae, Kim, Minwoo, Kim, Seon Hee, Kim, Dong Jo, Kim, Se Yong, Kim, Jonghyun, Kim, Jin Sook, Kim, Beomkyu, Kim, Taesoo, Kirsch, Stefan, Kisel, Ivan, Kiselev, Sergey, Kisiel, Adam Ryszard, Klay, Jennifer Lynn, Klein, Jochen, Klein-Bosing, Christian, Kliemant, Michael, Kluge, Alexander, Knichel, Michael Linus, Knospe, Anders Garritt, Koch, Kathrin, Kohler, Markus, Kolojvari, Anatoly, Kondratiev, Valery, Kondratyeva, Natalia, Konevskih, Artem, Korneev, Andrey, Kour, Ravjeet, Kowalski, Marek, Kox, Serge, Meethaleveedu, Greeshma Koyithatta, Kral, Jiri, Kralik, Ivan, Kramer, Frederick, Kraus, Ingrid Christine, Krawutschke, Tobias, Krelina, Michal, Kretz, Matthias, Krivda, Marian, Krizek, Filip, Krus, Miroslav, Kryshen, Evgeny, Krzewicki, Mikolaj, Kucheriaev, Yury, Kuhn, Christian Claude, Kuijer, Paul, Kulakov, Igor, Kumar, Jitendra, Kurashvili, Podist, Kurepin, A. B., Kurepin, A., Kuryakin, Alexey, Kushpil, Vasily, Kushpil, Svetlana, Kvaerno, Henning, Kweon, Min Jung, Kwon, Youngil, de Guevara, Pedro Ladron, Lakomov, Igor, Langoy, Rune, La Pointe, Sarah Louise, Lara, Camilo Ernesto, Lardeux, Antoine Xavier, La Rocca, Paola, Lazzeroni, Cristina, Lea, Ramona, Le Bornec, Yves, Lechman, Mateusz, Lee, Sung Chul, Lee, Ki Sang, Lee, Graham Richard, Lefevre, Frederic, Lehnert, Joerg Walter, Leistam, Lars, Lenhardt, Matthieu Laurent, Lenti, Vito, Leon, Hermes, Leoncino, Marco, Monzon, Ildefonso Leon, Vargas, Hermes Leon, Levai, Peter, Lien, Jorgen, Lietava, Roman, Lindal, Svein, Lindenstruth, Volker, Lippmann, Christian, Lisa, Michael Annan, Liu, Lijiao, Loenne, Per-Ivar, Loggins, Vera, Loginov, Vitaly, Lohn, Stefan Bernhard, Lohner, Daniel, Loizides, Constantinos, Loo, Kai Krister, Lopez, Xavier Bernard, Torres, Ernesto Lopez, Lovhoiden, Gunnar, Lu, Xianguo, Luettig, Philipp, Lunardon, Marcello, Luo, Jiebin, Luparello, Grazia, Luquin, Lionel, Luzzi, Cinzia, Ma, Rongrong, Ma, Ke, Madagodahettige-Don, Dilan Minthaka, Maevskaya, Alla, Mager, Magnus, Mahapatra, Durga Prasad, Maire, Antonin, Malaev, Mikhail, Cervantes, Ivonne Alicia Maldonado, Malinina, Ludmila, Mal’Kevich, Dmitry, Malzacher, Peter, Mamonov, Alexander, Manceau, Loic Henri Antoine, Mangotra, Lalit Kumar, Manko, Vladislav, Manso, Franck, Manzari, Vito, Mao, Yaxian, Marchisone, Massimiliano, Mares, Jiri, Margagliotti, Giacomo Vito, Margotti, Anselmo, Marin, Ana Maria, Tobon, Cesar Augusto Marin, Markert, Christina, Martashvili, Irakli, Martinengo, Paolo, Martinez, Mario Ivan, Davalos, Arnulfo Martinez, Garcia, Gines Martinez, Martynov, Yevgen, Mas, Alexis Jean-Michel, Masciocchi, Silvia, Masera, Massimo, Masoni, Alberto, Massacrier, Laure Marie, Mastromarco, Mario, Mastroserio, Annalisa, Matthews, Zoe Louise, Matyja, Adam Tomasz, Mayani, Daniel, Mayer, Christoph, Mazer, Joel, Mazzoni, Alessandra Maria, Meddi, Franco, Menchaca-Rocha, Arturo Alejandro, Perez, Jorge Mercado, Meres, Michal, Miake, Yasuo, Milano, Leonardo, Milosevic, Jovan, Mischke, Andre, Mishra, Aditya Nath, Miskowiec, Dariusz, Mitu, Ciprian Mihai, Mlynarz, Jocelyn, Mohanty, Bedangadas, Mohanty, Ajit Kumar, Molnar, Levente, Zetina, Luis Manuel Montano, Monteno, Marco, Montes, Esther, Moon, Taebong, Morando, Maurizio, De Godoy, Denise Aparecida Moreira, Moretto, Sandra, Morsch, Andreas, Muccifora, Valeria, Mudnic, Eugen, Muhuri, Sanjib, Mukherjee, Maitreyee, Muller, Hans, Munhoz, Marcelo, Musa, Luciano, Musso, Alfredo, Nandi, Basanta Kumar, Nania, Rosario, Nappi, Eugenio, Nattrass, Christine, Naumov, Nikolay, Navin, Sparsh, Nayak, Tapan Kumar, Nazarenko, Sergey, Nazarov, Gleb, Nedosekin, Alexander, Nicassio, Maria, Niculescu, Mihai, Nielsen, Borge Svane, Niida, Takafumi, Nikolaev, Sergey, Nikolic, Vedran, Nikulin, Sergey, Nikulin, Vladimir, Nilsen, Bjorn Steven, Nilsson, Mads Stormo, Noferini, Francesco, Nomokonov, Petr, Nooren, Gerardus, Novitzky, Norbert, Nyanin, Alexandre, Nyatha, Anitha, Nygaard, Casper, Nystrand, Joakim Ingemar, Ochirov, Alexander, Oeschler, Helmut Oskar, Oh, Saehanseul, Oh, Sun Kun, Oleniacz, Janusz, Oppedisano, Chiara, Velasquez, Antonio Ortiz, Ortona, Giacomo, Oskarsson, Anders Nils Erik, Ostrowski, Piotr Krystian, Otwinowski, Jacek Tomasz, Oyama, Ken, Ozawa, Kyoichiro, Pachmayer, Yvonne Chiara, Pachr, Milos, Padilla, Fatima, Pagano, Paola, Paic, Guy, Painke, Florian, Pajares, Carlos, Pal, S., Pal, Susanta Kumar, Palaha, Arvinder Singh, Palmeri, Armando, Papikyan, Vardanush, Pappalardo, Giuseppe, Park, Woo Jin, Passfeld, Annika, Pastircak, Blahoslav, Patalakha, Dmitri Ivanovich, Paticchio, Vincenzo, Pavlinov, Alexei, Pawlak, Tomasz Jan, Peitzmann, Thomas, Da Costa, Hugo Denis Antonio Pereira, De Oliveira Filho, Elienos Pereira, Peresunko, Dmitri, Lara, Carlos Eugenio Perez, Lezama, Edgar Perez, Perini, Diego, Perrino, Davide, Peryt, Wiktor Stanislaw, Pesci, Alessandro, Peskov, Vladimir, Pestov, Yury, Petracek, Vojtech, Petran, Michal, Petris, Mariana, Petrov, Plamen Rumenov, Petrovici, Mihai, Petta, Catia, Piano, Stefano, Piccotti, Anna, Pikna, Miroslav, Pillot, Philippe, Pinazza, Ombretta, Pinsky, Lawrence, Pitz, Nora, Piyarathna, Danthasinghe, Ploskon, Mateusz Andrzej, Pluta, Jan Marian, Pocheptsov, Timur, Pochybova, Sona, Lerma, Pedro Luis Manuel Podesta, Poghosyan, Martin, Polak, Karel, Polichtchouk, Boris, Pop, Amalia, Porteboeuf-Houssais, Sarah, Pospisil, Vladimir, Potukuchi, Baba, Prasad, Sidharth Kumar, Preghenella, Roberto, Prino, Francesco, Pruneau, Claude Andre, Pshenichnov, Igor, Puchagin, Sergey, Puddu, Giovanna, Teixido, Jordi Pujol, Pulvirenti, Alberto, Punin, Valery, Putis, Marian, Putschke, Jorn Henning, Quercigh, Emanuele, Qvigstad, Henrik, Rachevski, Alexandre, Rademakers, Alphonse, Radomski, Sylwester, Raiha, Tomi Samuli, Rak, Jan, Rakotozafindrabe, Andry Malala, Ramello, Luciano, Reyes, Abdiel Ramirez, Raniwala, Sudhir, Raniwala, Rashmi, Rasanen, Sami Sakari, Rascanu, Bogdan Theodor, Rathee, Deepika, Read, Kenneth Francis, Real, Jean-Sebastien, Redlich, Krzysztof, Reichelt, Patrick, Reicher, Martijn, Renfordt, Rainer Arno Ernst, Reolon, Anna Rita, Reshetin, Andrey, Rettig, Felix Vincenz, Revol, Jean-Pierre, Reygers, Klaus Johannes, Riccati, Lodovico, Ricci, Renato Angelo, Richert, Tuva, Richter, Matthias Rudolph, Riedler, Petra, Riegler, Werner, Riggi, Francesco, Rabacal, Bartolomeu Rodrigues Fernandes, Cahuantzi, Mario Rodriguez, Manso, Alis Rodriguez, Roed, Ketil, Rohr, David, Rohrich, Dieter, Romita, Rosa, Ronchetti, Federico, Rosnet, Philippe, Rossegger, Stefan, Rossi, Andrea, Roy, Christelle Sophie, Roy, Pradip Kumar, Montero, Antonio Juan Rubio, Rui, Rinaldo, Ryabinkin, Evgeny, Rybicki, Andrzej, Sadovsky, Sergey, Safarik, Karel, Sahoo, Raghunath, Sahu, Pradip Kumar, Saini, Jogender, Sakaguchi, Hiroaki, Sakai, Shingo, Sakata, Dosatsu, Salgado, Carlos Albert, Salzwedel, Jai, Sambyal, Sanjeev Singh, Samsonov, Vladimir, Castro, Xitzel Sanchez, Sandor, Ladislav, Sandoval, Andres, Sano, Satoshi, Sano, Masato, Santo, Rainer, Santoro, Romualdo, Sarkamo, Juho Jaako, Scapparone, Eugenio, Scarlassara, Fernando, Scharenberg, Rolf Paul, Schiaua, Claudiu Cornel, Schicker, Rainer Martin, Schmidt, Christian Joachim, Schmidt, Hans Rudolf, Schreiner, Steffen, Schuchmann, Simone, Schukraft, Jurgen, Schutz, Yves Roland, Schwarz, Kilian Eberhard, Schweda, Kai Oliver, Scioli, Gilda, Scomparin, Enrico, Scott, Rebecca, Scott, Patrick Aaron, Segato, Gianfranco, Selioujenkov, Ilya, Senyukov, Serhiy, Seo, Jeewon, Serci, Sergio, Serradilla, Eulogio, Sevcenco, Adrian, Shabetai, Alexandre, Shabratova, Galina, Shahoyan, Ruben, Sharma, Natasha, Sharma, Satish, Sharma, Rohini, Shigaki, Kenta, Shimomura, Maya, Shtejer, Katherin, Sibiriak, Yury, Siciliano, Melinda, Sicking, Eva, Siddhanta, Sabyasachi, Siemiarczuk, Teodor, Silvermyr, David Olle Rickard, Silvestre, Catherine, Simatovic, Goran, Simonetti, Giuseppe, Singaraju, Rama Narayana, Singh, Ranbir, Singha, Subhash, Singhal, Vikas, Sinha, Tinku, Sinha, Bikash, Sitar, Branislav, Sitta, Mario, Skaali, Bernhard, Skjerdal, Kyrre, Smakal, Radek, Smirnov, Nikolai, Snellings, Raimond, Sogaard, Carsten, Soltz, Ron Ariel, Son, Hyungsuk, Song, Myunggeun, Song, Jihye, Soos, Csaba, Soramel, Francesca, Sputowska, Iwona, Spyropoulou-Stassinaki, Martha, Srivastava, Brijesh Kumar, Stachel, Johanna, Stan, Ionel, Stan, Ionel, Stefanek, Grzegorz, Steinbeck, Timm Morten, Steinpreis, Matthew, Stenlund, Evert Anders, Steyn, Gideon Francois, Stiller, Johannes Hendrik, Stocco, Diego, Stolpovskiy, Mikhail, Strabykin, Kirill, Strmen, Peter, do Passo Suaide, Alexandre Alarcon, Vasquez, Martin Alfonso Subieta, Sugitate, Toru, Suire, Christophe Pierre, Sukhorukov, Mikhail, Sultanov, Rishat, Sumbera, Michal, Susa, Tatjana, de Toledo, Alejandro Szanto, Szarka, Imrich, Szczepankiewicz, Adam, Szostak, Artur Krzysztof, Szymanski, Maciej, Takahashi, Jun, Takaki, Daniel Jesus Tapia, Tauro, Arturo, Munoz, Guillermo Tejeda, Telesca, Adriana, Terrevoli, Cristina, Thader, Jochen Mathias, Thomas, Deepa, Tieulent, Raphael Noel, Timmins, Anthony, Tlusty, David, Toia, Alberica, Torii, Hisayuki, Toscano, Luca, Truesdale, David Christopher, Trzaska, Wladyslaw Henryk, Tsuji, Tomoya, Tumkin, Alexandr, Turrisi, Rosario, Tveter, Trine Spedstad, Ulery, Jason Glyndwr, Ullaland, Kjetil, Ulrich, Jochen, Uras, Antonio, Urban, Jozef, Urciuoli, Guido Marie, Usai, Gianluca, Vajzer, Michal, Vala, Martin, Palomo, Lizardo Valencia, Vallero, Sara, van der Kolk, Naomi, Vyvre, Pierre Vande, van Leeuwen, Marco, Vannucci, Luigi, Vargas, Aurora Diozcora, Varma, Raghava, Vasileiou, Maria, Vasiliev, Andrey, Vechernin, Vladimir, Veldhoen, Misha, Venaruzzo, Massimo, Vercellin, Ermanno, Vergara, Sergio, Vernet, Renaud, Verweij, Marta, Vickovic, Linda, Viesti, Giuseppe, Vikhlyantsev, Oleg, Vilakazi, Zabulon, Baillie, Orlando Villalobos, Vinogradov, Alexander, Vinogradov, Leonid, Vinogradov, Yury, Virgili, Tiziano, Viyogi, Yogendra, Vodopianov, Alexander, Voloshin, Kirill, Voloshin, Sergey, Volpe, Giacomo, von Haller, Barthelemy, Vranic, Danilo, vrebekk, Gaute, Vrlakova, Janka, Vulpescu, Bogdan, Vyushin, Alexey, Wagner, Vladimir, Wagner, Boris, Wan, Renzhuo, Wang, Mengliang, Wang, Dong, Wang, Yifei, Wang, Yaping, Watanabe, Kengo, Weber, Michael, Wessels, Johannes, Westerhoff, Uwe, Wiechula, Jens, Wikne, Jon, Wilde, Martin Rudolf, Wilk, Grzegorz Andrzej, Wilk, Alexander, Williams, Crispin, Windelband, Bernd Stefan, Karampatsos, Leonidas Xaplanteris, Yaldo, Chris G, Yamaguchi, Yorito, Yang, Hongyan, Yang, Shiming, Yasnopolsky, Stanislav, Yi, JunGyu, Yin, Zhongbao, Yoo, In-Kwon, Yoon, Jongik, Yu, Weilin, Yuan, Xianbao, Yushmanov, Igor, Zach, Cenek, Zampolli, Chiara, Zaporozhets, Sergey, Zarochentsev, Andrey, Zavada, Petr, Zaviyalov, Nikolai, Zbroszczyk, Hanna Paulina, Zelnicek, Pierre, Zgura, Sorin Ion, Zhalov, Mikhail, Zhang, Xiaoming, Zhang, Haitao, Zhou, Fengchu, Zhou, Daicui, Zhou, You, Zhu, Jianhui, Zhu, Jianlin, Zhu, Xiangrong, Zichichi, Antonino, Zimmermann, Alice, Zinovjev, Gennady, Zoccarato, Yannick Denis, Zynovyev, Mykhaylo, Zyzak, Maksym, and The ALICE Collaboration

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2012
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27. Underlying Event measurements in pp collisions at $ \sqrt {s} = 0.9 $ and 7 TeV with the ALICE experiment at the LHC

Author

Abelev, Betty, Quintana, Arian Abrahantes, Adamova, Dagmar, Adare, Andrew Marshall, Aggarwal, Madan, Rinella, Gianluca Aglieri, Agocs, Andras Gabor, Agostinelli, Andrea, Salazar, Saul Aguilar, Ahammed, Zubayer, Ahmad, Nazeer, Ahmad, Arshad, Ahn, Sang Un, Akindinov, Alexander, Aleksandrov, Dmitry, Alessandro, Bruno, Molina, Jose Ruben Alfaro, Alici, Andrea, Alkin, Anton, Avina, Erick Jonathan Almaraz, Alt, Torsten, Altini, Valerio, Altinpinar, Sedat, Altsybeev, Igor, Andrei, Cristian, Andronic, Anton, Anguelov, Venelin, Anson, Christopher Daniel, Anticic, Tome, Antinori, Federico, Antonioli, Pietro, Aphecetche, Laurent Bernard, Appelshauser, Harald, Arbor, Nicolas, Arcelli, Silvia, Arend, Andreas, Armesto, Nestor, Arnaldi, Roberta, Aronsson, Tomas Robert, Arsene, Ionut Cristian, Arslandok, Mesut, Asryan, Andzhey, Augustinus, Andre, Averbeck, Ralf Peter, Awes, Terry, Aysto, Juha Heikki, Azmi, Mohd Danish, Bach, Matthias Jakob, Badala, Angela, Baek, Yong Wook, Bailhache, Raphaelle Marie, Bala, Renu, Ferroli, Rinaldo Baldini, Baldisseri, Alberto, Baldit, Alain, Pedrosa, Fernando Baltasar Dos Santos, Ban, Jaroslav, Baral, Rama Chandra, Barbera, Roberto, Barile, Francesco, Barnafoldi, Gergely Gabor, Barnby, Lee Stuart, Barret, Valerie, Bartke, Jerzy Gustaw, Basile, Maurizio, Bastid, Nicole, Bathen, Bastian, Batigne, Guillaume, Batyunya, Boris, Baumann, Christoph Heinrich, Bearden, Ian Gardner, Beck, Hans, Belikov, Iouri, Bellini, Francesca, Bellwied, Rene, Belmont-Moreno, Ernesto, Beole, Stefania, Berceanu, Ionela, Bercuci, Alexandru, Berdnikov, Yaroslav, Berenyi, Daniel, Bergmann, Cyrano, Berzano, Dario, Betev, Latchezar, Bhasin, Anju, Bhati, Ashok Kumar, Bianchi, Nicola, Bianchi, Livio, Bianchin, Chiara, Bielcik, Jaroslav, Bielcikova, Jana, Bilandzic, Ante, Blanco, F., Blanco, Francesco, Blau, Dmitry, Blume, Christoph, Boccioli, Marco, Bock, Nicolas, Bogdanov, Alexey, Boggild, Hans, Bogolyubsky, Mikhail, Boldizsar, Laszlo, Bombara, Marek, Book, Julian, Borel, Herve, Borissov, Alexander, Bortolin, Claudio, Bose, Suvendu Nath, Bossu, Francesco, Botje, Michiel, Bottger, Stefan, Boyer, Bruno Alexandre, Braun-Munzinger, Peter, Bregant, Marco, Breitner, Timo Gunther, Broz, Michal, Brun, Rene, Bruna, Elena, Bruno, Giuseppe Eugenio, Budnikov, Dmitry, Buesching, Henner, Bufalino, Stefania, Bugaiev, Kyrylo, Busch, Oliver, Buthelezi, Edith Zinhle, Caffarri, Davide, Cai, Xu, Caines, Helen Louise, Villar, Ernesto Calvo, Camerini, Paolo, Roman, Veronica Canoa, Romeo, Giovanni Cara, Carena, Francesco, Carena, Wisla, Filho, Nelson Carlin, Carminati, Federico, Montoya, Camilo Andres Carrillo, Diaz, Amaya Ofelia Casanova, Caselle, Michele, Castellanos, Javier Ernesto Castillo, Hernandez, Juan Francisco Castillo, Casula, Ester Anna Rita, Catanescu, Vasile, Cavicchioli, Costanza, Cepila, Jan, Cerello, Piergiorgio, Chang, Beomsu, Chapeland, Sylvain, Charvet, Jean-Luc Fernand, Chattopadhyay, Sukalyan, Chattopadhyay, Subhasis, Cherney, Michael Gerard, Cheshkov, Cvetan, Cheynis, Brigitte, Chiavassa, Emilio, Barroso, Vasco Miguel Chibante, Chinellato, David, Chochula, Peter, Chojnacki, Marek, Christakoglou, Panagiotis, Christensen, Christian Holm, Christiansen, Peter, Chujo, Tatsuya, Chung, Suh-Urk, Cicalo, Corrado, Cifarelli, Luisa, Cindolo, Federico, Cleymans, Jean Willy Andre, Coccetti, Fabrizio, Coffin, Jean-Pierre Michel, Colamaria, Fabio, Colella, Domenico, Balbastre, Gustavo Conesa, del Valle, Zaida Conesa, Constantin, Paul, Contin, Giacomo, Contreras, Jesus Guillermo, Cormier, Thomas Michael, Morales, Yasser Corrales, Cortese, Pietro, Maldonado, Ismael Cortes, Cosentino, Mauro Rogerio, Costa, Filippo, Cotallo, Manuel Enrique, Crescio, Elisabetta, Crochet, Philippe, Alaniz, Emilia Cruz, Cuautle, Eleazar, Cunqueiro, Leticia, Dainese, Andrea, Dalsgaard, Hans Hjersing, Danu, Andrea, Das, Indranil, Das, Kushal, Das, Debasish, Dash, Ajay Kumar, Dash, Sadhana, De, Sudipan, De Azevedo Moregula, Andrea, de Barros, Gabriel, De Caro, Annalisa, de Cataldo, Giacinto, de Cuveland, Jan, De Falco, Alessandro, De Gruttola, Daniele, Delagrange, Hugues, Del Castillo Sanchez, Eduardo, Deloff, Andrzej, Demanov, Vyacheslav, De Marco, Nora, Denes, Ervin, De Pasquale, Salvatore, Deppman, Airton, D’Erasmo, Ginevra, de Rooij, Raoul Stefan, Di Bari, Domenico, Dietel, Thomas, Di Giglio, Carmelo, Di Liberto, Sergio, Di Mauro, Antonio, Di Nezza, Pasquale, Divia, Roberto, Djuvsland, Oeystein, Dobrin, Alexandru Florin, Dobrowolski, Tadeusz Antoni, Dominguez, Isabel, Donigus, Benjamin, Dordic, Olja, Driga, Olga, Dubey, Anand Kumar, Ducroux, Laurent, Dupieux, Pascal, Majumdar, Mihir Ranjan Dutta, Majumdar, A.K. Dutta, Elia, Domenico, Emschermann, David Philip, Engel, Heiko, Erdal, Hege Austrheim, Espagnon, Bruno, Estienne, Magali Danielle, Esumi, Shinichi, Evans, David, Eyyubova, Gyulnara, Fabris, Daniela, Faivre, Julien, Falchieri, Davide, Fantoni, Alessandra, Fasel, Markus, Fearick, Roger Worsley, Fedunov, Anatoly, Fehlker, Dominik, Feldkamp, Linus, Felea, Daniel, Feofilov, Grigory, Tellez, Arturo Fernandez, Ferretti, Alessandro, Ferretti, Roberta, Figiel, Jan, Figueredo, Marcel, Filchagin, Sergey, Fini, Rosa Anna, Finogeev, Dmitry, Fionda, Fiorella, Fiore, Enrichetta Maria, Floris, Michele, Foertsch, Siegfried Valentin, Foka, Panagiota, Fokin, Sergey, Fragiacomo, Enrico, Fragkiadakis, Michail, Frankenfeld, Ulrich Michael, Fuchs, Ulrich, Furget, Christophe, Girard, Mario Fusco, Gaardhoje, Jens Joergen, Gagliardi, Martino, Gago, Alberto, Gallio, Mauro, Gangadharan, Dhevan Raja, Ganoti, Paraskevi, Garabatos, Jose, Garcia-Solis, Edmundo, Garishvili, Irakli, Gerhard, Jochen, Germain, Marie, Geuna, Claudio, Gheata, Andrei George, Gheata, Mihaela, Ghidini, Bruno, Ghosh, Premomoy, Gianotti, Paola, Girard, Martin Robert, Giubellino, Paolo, Gladysz-Dziadus, Ewa, Glassel, Peter, Gomez, Ramon, Ferreiro, Elena Gonzalez, Gonzalez-Trueba, Laura Helena, Gonzalez-Zamora, Pedro, Gorbunov, Sergey, Goswami, Ankita, Gotovac, Sven, Grabski, Varlen, Graczykowski, Lukasz Kamil, Grajcarek, Robert, Grelli, Alessandro, Grigoras, Costin, Grigoras, Alina Gabriela, Grigoriev, Vladislav, Grigoryan, Ara, Grigoryan, Smbat, Grinyov, Boris, Grion, Nevio, Gros, Philippe, Grosse-Oetringhaus, Jan Fiete, Grossiord, Jean-Yves, Grosso, Raffaele, Guber, Fedor, Guernane, Rachid, Gutierrez, Cesar Guerra, Guerzoni, Barbara, Guilbaud, Maxime Rene Joseph, Gulbrandsen, Kristjan Herlache, Gunji, Taku, Gupta, Anik, Gupta, Ramni, Gutbrod, Hans, Haaland, Oystein Senneset, Hadjidakis, Cynthia Marie, Haiduc, Maria, Hamagaki, Hideki, Hamar, Gergoe, Han, Byounghee, Hanratty, Luke David, Hansen, Alexander, Harmanova, Zuzana, Harris, John William, Hartig, Matthias, Hasegan, Dumitru, Hatzifotiadou, Despoina, Hayrapetyan, Arsen, Heckel, Stefan Thomas, Heide, Markus Ansgar, Helstrup, Haavard, Herghelegiu, Andrei Ionut, Corral, Gerardo Antonio Herrera, Herrmann, Norbert, Hetland, Kristin Fanebust, Hicks, Bernard, Hille, Per Thomas, Hippolyte, Boris, Horaguchi, Takuma, Hori, Yasuto, Hristov, Peter Zahariev, Hrivnacova, Ivana, Huang, Meidana, Huber, Sebastian Bernd, Humanic, Thomas, Hwang, Dae Sung, Ichou, Raphaelle, Ilkaev, Radiy, Ilkiv, Iryna, Inaba, Motoi, Incani, Elisa, Innocenti, Pier Giorgio, Innocenti, Gian Michele, Ippolitov, Mikhail, Irfan, Muhammad, Ivan, Cristian George, Ivanov, Marian, Ivanov, Vladimir, Ivanov, Andrey, Ivanytskyi, Oleksii, Jacholkowski, Adam Wlodzimierz, Jacobs, Peter, Jancurova, Lucia, Jang, Haeng Jin, Jangal, Swensy Gwladys, Janik, Rudolf, Janik, Malgorzata Anna, Jayarathna, Sandun, Jena, Satyajit, Bustamante, Raul Tonatiuh Jimenez, Jirden, Lennart, Jones, Peter Graham, Jung, Won Woong, Jung, Hyung Taik, Jusko, Anton, Kaidalov, Alexei, Kakoyan, Vanik, Kalcher, Sebastian, Kalinak, Peter, Kalisky, Matus, Kalliokoski, Tuomo Esa Aukusti, Kalweit, Alexander Philipp, Kanaki, Kalliopi, Kang, Ju Hwan, Kaplin, Vladimir, Uysal, Ayben Karasu, Karavichev, Oleg, Karavicheva, Tatiana, Karpechev, Evgeny, Kazantsev, Andrey, Kebschull, Udo Wolfgang, Keidel, Ralf, Khan, Palash, Khan, Mohisin Mohammed, Khan, Shuaib Ahmad, Khanzadeev, Alexei, Kharlov, Yury, Kileng, Bjarte, Kim, Jonghyun, Kim, Dong Jo, Kim, Do Won, Kim, Jin Sook, Kim, Minwoo, Kim, Seon Hee, Kim, Se Yong, Kim, Beomkyu, Kim, Taesoo, Kirsch, Stefan, Kisel, Ivan, Kiselev, Sergey, Kisiel, Adam Ryszard, Klay, Jennifer Lynn, Klein, Jochen, Klein-Bosing, Christian, Kliemant, Michael, Kluge, Alexander, Knichel, Michael Linus, Koch, Kathrin, Kohler, Markus, Kolojvari, Anatoly, Kondratiev, Valery, Kondratyeva, Natalia, Konevskih, Artem, Korneev, Andrey, Don, Chamath Kottachchi Kankanamge, Kour, Ravjeet, Kowalski, Marek, Kox, Serge, Meethaleveedu, Greeshma Koyithatta, Kral, Jiri, Kralik, Ivan, Kramer, Frederick, Kraus, Ingrid Christine, Krawutschke, Tobias, Kretz, Matthias, Krivda, Marian, Krizek, Filip, Krus, Miroslav, Kryshen, Evgeny, Krzewicki, Mikolaj, Kucheriaev, Yury, Kuhn, Christian Claude, Kuijer, Paul, Kurashvili, Podist, Kurepin, A.B., Kurepin, A., Kuryakin, Alexey, Kushpil, Svetlana, Kushpil, Vasily, Kvaerno, Henning, Kweon, Min Jung, Kwon, Youngil, de Guevara, Pedro Ladron, Lakomov, Igor, Langoy, Rune, Lara, Camilo Ernesto, Lardeux, Antoine Xavier, La Rocca, Paola, Lazzeroni, Cristina, Lea, Ramona, Le Bornec, Yves, Lee, Sung Chul, Lee, Ki Sang, Lefevre, Frederic, Lehnert, Joerg Walter, Leistam, Lars, Lenhardt, Matthieu Laurent, Lenti, Vito, Leon, Hermes, Monzon, Ildefonso Leon, Vargas, Hermes Leon, Levai, Peter, Li, Xiaomei, Lien, Jorgen, Lietava, Roman, Lindal, Svein, Lindenstruth, Volker, Lippmann, Christian, Lisa, Michael Annan, Liu, Lijiao, Loenne, Per-Ivar, Loggins, Vera, Loginov, Vitaly, Lohn, Stefan Bernhard, Lohner, Daniel, Loizides, Constantinos, Loo, Kai Krister, Lopez, Xavier Bernard, Torres, Ernesto Lopez, Lovhoiden, Gunnar, Lu, Xianguo, Luettig, Philipp, Lunardon, Marcello, Luo, Jiebin, Luparello, Grazia, Luquin, Lionel, Luzzi, Cinzia, Ma, Rongrong, Ma, Ke, Madagodahettige-Don, Dilan Minthaka, Maevskaya, Alla, Mager, Magnus, Mahapatra, Durga Prasad, Maire, Antonin, Malaev, Mikhail, Cervantes, Ivonne Alicia Maldonado, Malinina, Ludmila, Mal’Kevich, Dmitry, Malzacher, Peter, Mamonov, Alexander, Manceau, Loic Henri Antoine, Mangotra, Lalit Kumar, Manko, Vladislav, Manso, Franck, Manzari, Vito, Mao, Yaxian, Marchisone, Massimiliano, Mares, Jiri, Margagliotti, Giacomo Vito, Margotti, Anselmo, Marin, Ana Maria, Markert, Christina, Martashvili, Irakli, Martinengo, Paolo, Martinez, Mario Ivan, Davalos, Arnulfo Martinez, Garcia, Gines Martinez, Martynov, Yevgen, Mas, Alexis Jean-Michel, Masciocchi, Silvia, Masera, Massimo, Masoni, Alberto, Massacrier, Laure Marie, Mastromarco, Mario, Mastroserio, Annalisa, Matthews, Zoe Louise, Matyja, Adam Tomasz, Mayani, Daniel, Mayer, Christoph, Mazer, Joel, Mazzoni, Alessandra Maria, Meddi, Franco, Menchaca-Rocha, Arturo Alejandro, Perez, Jorge Mercado, Meres, Michal, Miake, Yasuo, Michalon, Alain, Midori, Jumpei, Milano, Leonardo, Milosevic, Jovan, Mischke, Andre, Mishra, Aditya Nath, Miskowiec, Dariusz, Mitu, Ciprian Mihai, Mlynarz, Jocelyn, Mohanty, Ajit Kumar, Mohanty, Bedangadas, Molnar, Levente, Zetina, Luis Manuel Montano, Monteno, Marco, Montes, Esther, Moon, Taebong, Morando, Maurizio, De Godoy, Denise Aparecida Moreira, Moretto, Sandra, Morsch, Andreas, Muccifora, Valeria, Mudnic, Eugen, Muhuri, Sanjib, Muller, Hans, Munhoz, Marcelo, Musa, Luciano, Musso, Alfredo, Nandi, Basanta Kumar, Nania, Rosario, Nappi, Eugenio, Nattrass, Christine, Naumov, Nikolay, Navin, Sparsh, Nayak, Tapan Kumar, Nazarenko, Sergey, Nazarov, Gleb, Nedosekin, Alexander, Nicassio, Maria, Nielsen, Borge Svane, Niida, Takafumi, Nikolaev, Sergey, Nikolic, Vedran, Nikulin, Vladimir, Nikulin, Sergey, Nilsen, Bjorn Steven, Nilsson, Mads Stormo, Noferini, Francesco, Nomokonov, Petr, Nooren, Gerardus, Novitzky, Norbert, Nyanin, Alexandre, Nyatha, Anitha, Nygaard, Casper, Nystrand, Joakim Ingemar, Obayashi, Hideyuki, Ochirov, Alexander, Oeschler, Helmut Oskar, Oh, Sun Kun, Oh, Saehanseul, Oleniacz, Janusz, Oppedisano, Chiara, Velasquez, Antonio Ortiz, Ortona, Giacomo, Oskarsson, Anders Nils Erik, Ostrowski, Piotr Krystian, Otterlund, Ingvar, Otwinowski, Jacek Tomasz, Oyama, Ken, Ozawa, Kyoichiro, Pachmayer, Yvonne Chiara, Pachr, Milos, Padilla, Fatima, Pagano, Paola, Paic, Guy, Painke, Florian, Pajares, Carlos, Pal, S., Pal, Susanta Kumar, Palaha, Arvinder Singh, Palmeri, Armando, Papikyan, Vardanush, Pappalardo, Giuseppe, Park, Woo Jin, Passfeld, Annika, Pastircak, Blahoslav, Patalakha, Dmitri Ivanovich, Paticchio, Vincenzo, Pavlinov, Alexei, Pawlak, Tomasz Jan, Peitzmann, Thomas, Perales, Marianela, De Oliveira Filho, Elienos Pereira, Peresunko, Dmitri, Lara, Carlos Eugenio Perez, Lezama, Edgar Perez, Perini, Diego, Perrino, Davide, Peryt, Wiktor Stanislaw, Pesci, Alessandro, Peskov, Vladimir, Pestov, Yury, Petracek, Vojtech, Petran, Michal, Petris, Mariana, Petrov, Plamen Rumenov, Petrovici, Mihai, Petta, Catia, Piano, Stefano, Piccotti, Anna, Pikna, Miroslav, Pillot, Philippe, Pinazza, Ombretta, Pinsky, Lawrence, Pitz, Nora, Piuz, Francois, Piyarathna, Danthasinghe, Ploskon, Mateusz Andrzej, Pluta, Jan Marian, Pocheptsov, Timur, Pochybova, Sona, Lerma, Pedro Luis Manuel Podesta, Poghosyan, Martin, Polak, Karel, Polichtchouk, Boris, Pop, Amalia, Porteboeuf-Houssais, Sarah, Pospisil, Vladimir, Potukuchi, Baba, Prasad, Sidharth Kumar, Preghenella, Roberto, Prino, Francesco, Pruneau, Claude Andre, Pshenichnov, Igor, Puchagin, Sergey, Puddu, Giovanna, Pulvirenti, Alberto, Punin, Valery, Putis, Marian, Putschke, Jorn Henning, Quercigh, Emanuele, Qvigstad, Henrik, Rachevski, Alexandre, Rademakers, Alphonse, Radomski, Sylwester, Raiha, Tomi Samuli, Rak, Jan, Rakotozafindrabe, Andry Malala, Ramello, Luciano, Reyes, Abdiel Ramirez, Raniwala, Sudhir, Raniwala, Rashmi, Rasanen, Sami Sakari, Rascanu, Bogdan Theodor, Rathee, Deepika, Read, Kenneth Francis, Real, Jean-Sebastien, Redlich, Krzysztof, Reichelt, Patrick, Reicher, Martijn, Renfordt, Rainer Arno Ernst, Reolon, Anna Rita, Reshetin, Andrey, Rettig, Felix Vincenz, Revol, Jean-Pierre, Reygers, Klaus Johannes, Riccati, Lodovico, Ricci, Renato Angelo, Richter, Matthias Rudolph, Riedler, Petra, Riegler, Werner, Riggi, Francesco, Cahuantzi, Mario Rodriguez, Rohr, David, Rohrich, Dieter, Romita, Rosa, Ronchetti, Federico, Rosnet, Philippe, Rossegger, Stefan, Rossi, Andrea, Roukoutakis, Filimon, Roy, Pradip Kumar, Roy, Christelle Sophie, Montero, Antonio Juan Rubio, Rui, Rinaldo, Ryabinkin, Evgeny, Rybicki, Andrzej, Sadovsky, Sergey, Safarik, Karel, Sahu, Pradip Kumar, Saini, Jogender, Sakaguchi, Hiroaki, Sakai, Shingo, Sakata, Dosatsu, Salgado, Carlos Albert, Sambyal, Sanjeev Singh, Samsonov, Vladimir, Castro, Xitzel Sanchez, Sandor, Ladislav, Sandoval, Andres, Sano, Masato, Sano, Satoshi, Santo, Rainer, Santoro, Romualdo, Sarkamo, Juho Jaako, Scapparone, Eugenio, Scarlassara, Fernando, Scharenberg, Rolf Paul, Schiaua, Claudiu Cornel, Schicker, Rainer Martin, Schmidt, Christian Joachim, Schmidt, Hans Rudolf, Schreiner, Steffen, Schuchmann, Simone, Schukraft, Jurgen, Schutz, Yves Roland, Schwarz, Kilian Eberhard, Schweda, Kai Oliver, Scioli, Gilda, Scomparin, Enrico, Scott, Rebecca, Scott, Patrick Aaron, Segato, Gianfranco, Selioujenkov, Ilya, Senyukov, Serhiy, Seo, Jeewon, Serci, Sergio, Serradilla, Eulogio, Sevcenco, Adrian, Sgura, Irene, Shabetai, Alexandre, Shabratova, Galina, Shahoyan, Ruben, Sharma, Natasha, Sharma, Satish, Shigaki, Kenta, Shimomura, Maya, Shtejer, Katherin, Sibiriak, Yury, Siciliano, Melinda, Sicking, Eva, Siddhanta, Sabyasachi, Siemiarczuk, Teodor, Silvermyr, David Olle Rickard, Simonetti, Giuseppe, Singaraju, Rama Narayana, Singh, Ranbir, Singha, Subhash, Sinha, Bikash, Sinha, Tinku, Sitar, Branislav, Sitta, Mario, Skaali, Bernhard, Skjerdal, Kyrre, Smakal, Radek, Smirnov, Nikolai, Snellings, Raimond, Sogaard, Carsten, Soltz, Ron Ariel, Son, Hyungsuk, Song, Jihye, Song, Myunggeun, Soos, Csaba, Soramel, Francesca, Sputowska, Iwona, Spyropoulou-Stassinaki, Martha, Srivastava, Brijesh Kumar, Stachel, Johanna, Stan, Ionel, Stan, Ionel, Stefanek, Grzegorz, Stefanini, Giorgio, Steinbeck, Timm Morten, Steinpreis, Matthew, Stenlund, Evert Anders, Steyn, Gideon Francois, Stocco, Diego, Stolpovskiy, Mikhail, Strabykin, Kirill, Strmen, Peter, do Passo Suaide, Alexandre Alarcon, Vasquez, Martin Alfonso Subieta, Sugitate, Toru, Suire, Christophe Pierre, Sukhorukov, Mikhail, Sultanov, Rishat, Sumbera, Michal, Susa, Tatjana, de Toledo, Alejandro Szanto, Szarka, Imrich, Szostak, Artur Krzysztof, Tagridis, Christos, Takahashi, Jun, Takaki, Daniel Jesus Tapia, Tauro, Arturo, Munoz, Guillermo Tejeda, Telesca, Adriana, Terrevoli, Cristina, Thader, Jochen Mathias, Thomas, Jim, Thomas, Deepa, Tieulent, Raphael Noel, Timmins, Anthony, Tlusty, David, Toia, Alberica, Torii, Hisayuki, Toscano, Luca, Tosello, Flavio, Traczyk, Tomasz, Truesdale, David Christopher, Trzaska, Wladyslaw Henryk, Tsuji, Tomoya, Tumkin, Alexandr, Turrisi, Rosario, Tveter, Trine Spedstad, Ulery, Jason Glyndwr, Ullaland, Kjetil, Ulrich, Jochen, Uras, Antonio, Urban, Jozef, Urciuoli, Guido Marie, Usai, Gianluca, Vajzer, Michal, Vala, Martin, Palomo, Lizardo Valencia, Vallero, Sara, van der Kolk, Naomi, Vyvre, Pierre Vande, van Leeuwen, Marco, Vannucci, Luigi, Vargas, Aurora Diozcora, Varma, Raghava, Vasileiou, Maria, Vasiliev, Andrey, Vechernin, Vladimir, Veldhoen, Misha, Venaruzzo, Massimo, Vercellin, Ermanno, Vergara, Sergio, Vernekohl, Don Constantin, Vernet, Renaud, Verweij, Marta, Vickovic, Linda, Viesti, Giuseppe, Vikhlyantsev, Oleg, Vilakazi, Zabulon, Baillie, Orlando Villalobos, Vinogradov, Leonid, Vinogradov, Yury, Vinogradov, Alexander, Virgili, Tiziano, Viyogi, Yogendra, Vodopianov, Alexander, Voloshin, Sergey, Voloshin, Kirill, Volpe, Giacomo, von Haller, Barthelemy, Vranic, Danilo, vrebekk, Gaute, Vrlakova, Janka, Vulpescu, Bogdan, Vyushin, Alexey, Wagner, Boris, Wagner, Vladimir, Wan, Renzhuo, Wang, Yifei, Wang, Mengliang, Wang, Dong, Wang, Yaping, Watanabe, Kengo, Wessels, Johannes, Westerhoff, Uwe, Wiechula, Jens, Wikne, Jon, Wilde, Martin Rudolf, Wilk, Grzegorz Andrzej, Wilk, Alexander, Williams, Crispin, Windelband, Bernd Stefan, Karampatsos, Leonidas Xaplanteris, Yang, Hongyan, Yang, Shiming, Yano, Satoshi, Yasnopolsky, Stanislav, Yi, JunGyu, Yin, Zhongbao, Yokoyama, Hiroki, Yoo, In-Kwon, Yoon, Jongik, Yu, Weilin, Yuan, Xianbao, Yushmanov, Igor, Zach, Cenek, Zampolli, Chiara, Zaporozhets, Sergey, Zarochentsev, Andrey, Zavada, Petr, Zaviyalov, Nikolai, Zbroszczyk, Hanna Paulina, Zelnicek, Pierre, Zgura, Sorin Ion, Zhalov, Mikhail, Zhang, Xiaoming, Zhou, Fengchu, Zhou, You, Zhou, Daicui, Zhu, Xiangrong, Zichichi, Antonino, Zimmermann, Alice, Zinovjev, Gennady, Zoccarato, Yannick Denis, Zynovyev, Mykhaylo, and The ALICE collaboration

Published
2012
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30. Defective ribosome assembly impairs leukemia progression in a murine model of acute myeloid leukemia

Author

Sjövall, Daniel, Ghosh, Sudip, Fernandez-Fuentes, Narcis, Velasco-Hernandez, Talia, Hogmalm, Anna, Menendez, Pablo, Hansson, Jenny, Guibentif, Carolina, and Jaako, Pekka

Abstract

Despite an advanced understanding of disease mechanisms, the current therapeutic regimen fails to cure most patients with acute myeloid leukemia (AML). In the present study, we address the role of ribosome assembly in leukemia cell function. We apply patient datasets and murine models to demonstrate that immature leukemia cells in mixed-lineage leukemia-rearranged AML are characterized by relatively high ribosome biogenesis and protein synthesis rates. Using a model with inducible regulation of ribosomal subunit joining, we show that defective ribosome assembly extends survival in mice with AML. Single-cell RNA sequencing and proteomic analyses reveal that leukemia cell adaptation to defective ribosome assembly is associated with an increase in ribosome biogenesis and deregulation of the transcription factor landscape. Finally, we demonstrate that defective ribosome assembly shows antileukemia efficacy in p53-deficient AML. Our study unveils the critical requirement of a high protein synthesis rate for leukemia progression and highlights ribosome assembly as a therapeutic target in AML.

Published
2024
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31. The Information Society and the New Competence.

Author

Lehtonen, Jaako

Abstract

Argues that in an information age competence of an individual cannot be discerned in the product they produce but on the impression they make, therefore marketing through impressions provides basis for decision making. Sees challenge to education in teaching how to process information in the most appropriate way. (KO)

Published
1988

32. Induction of the 5S RNP-Mdm2-p53 ribosomal stress pathway delays the initiation but fails to eradicate established murine acute myeloid leukemia

Author

Jaako, P., Ugale, A., Wahlestedt, M., Velasco-Hernandez, T., Cammenga, Jörg, Lindström, M. S., Bryder, D., Jaako, P., Ugale, A., Wahlestedt, M., Velasco-Hernandez, T., Cammenga, Jörg, Lindström, M. S., and Bryder, D.

Abstract

Mutations resulting in constitutive activation of signaling pathways that regulate ribosome biogenesis are among the most common genetic events in acute myeloid leukemia (AML). However, whether ribosome biogenesis presents as a therapeutic target to treat AML remains unexplored. Perturbations in ribosome biogenesis trigger the 5S ribonucleoprotein particle (RNP)-Mdm2-p53 ribosomal stress pathway, and induction of this pathway has been shown to have therapeutic efficacy in Myc-driven lymphoma. In the current study we address the physiological and therapeutic role of the 5S RNP-Mdm2-p53 pathway in AML. By utilizing mice that have defective ribosome biogenesis due to downregulation of ribosomal protein S19 (Rps19), we demonstrate that induction of the 5S RNP-Mdm2-p53 pathway significantly delays the initiation of AML. However, even a severe Rps19 deficiency that normally results in acute bone marrow failure has no consistent efficacy on already established disease. Finally, by using mice that harbor a mutation in the Mdm2 gene disrupting its binding to 5S RNP, we show that loss of the 5S RNP-Mdm2-p53 pathway is dispensable for development of AML. Our study suggests that induction of the 5S RNP-Mdm2-p53 ribosomal stress pathway holds limited potential as a single-agent therapy in the treatment of AML., Funding Agencies|Swedish Childrens Cancer Society; Crafoord Foundation; Gunnar Nilsson Cancer Foundation; Swedish Research Council; Swedish Cancer Society; ERC Consolidator grant [615068]

Published
2017
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34. EFL1 mutations impair eIF6 release to cause Shwachman-Diamond syndrome

Author

Tan, Shengjiang, Kermasson, Laëtitia, Hoslin, Angela, Jaako, Pekka, Faille, Alexandre, Acevedo-Arozena, Abraham, Lengline, Etienne, Ranta, Dana, Poirée, Maryline, Fenneteau, Odile, Ducou le Pointe, Hubert, Fumagalli, Stefano, Beaupain, Blandine, Nitschké, Patrick, Bôle-Feysot, Christine, de Villartay, Jean-Pierre, Bellanné-Chantelot, Christine, Donadieu, Jean, Kannengiesser, Caroline, Warren, Alan J., and Revy, Patrick

Abstract

Shwachman-Diamond syndrome (SDS) is a recessive disorder typified by bone marrow failure and predisposition to hematological malignancies. SDS is predominantly caused by deficiency of the allosteric regulator Shwachman-Bodian-Diamond syndrome that cooperates with elongation factor-like GTPase 1 (EFL1) to catalyze release of the ribosome antiassociation factor eIF6 and activate translation. Here, we report biallelic mutations in EFL1 in 3 unrelated individuals with clinical features of SDS. Cellular defects in these individuals include impaired ribosomal subunit joining and attenuated global protein translation as a consequence of defective eIF6 eviction. In mice, Efl1 deficiency recapitulates key aspects of the SDS phenotype. By identifying biallelic EFL1 mutations in SDS, we define this leukemia predisposition disorder as a ribosomopathy that is caused by corruption of a fundamental, conserved mechanism, which licenses entry of the large ribosomal subunit into translation.

Published
2019
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35. Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan anaemia

Author

Sjogren, SE, Siva, K, Soneji, S, George, AJ, Winkler, M, Jaako, P, Wlodarski, M, Karlsson, S, Hannan, RD, Flygare, J, Sjogren, SE, Siva, K, Soneji, S, George, AJ, Winkler, M, Jaako, P, Wlodarski, M, Karlsson, S, Hannan, RD, and Flygare, J

Abstract

Diamond-Blackfan anaemia (DBA) is a rare congenital disease causing severe anaemia and progressive bone marrow failure. The majority of patients carry mutations in ribosomal proteins, which leads to depletion of erythroid progenitors in the bone marrow. As many as 40% of all DBA patients receive glucocorticoids to alleviate their anaemia. However, despite their use in DBA treatment for more than half a century, the therapeutic mechanisms of glucocorticoids remain largely unknown. Therefore we sought to study disease specific effects of glucocorticoid treatment using a ribosomal protein s19 (Rps19) deficient mouse model of DBA. This study determines for the first time that a mouse model of DBA can respond to glucocorticoid treatment, similar to DBA patients. Our results demonstrate that glucocorticoid treatment reduces apoptosis, rescues erythroid progenitor depletion and premature differentiation of erythroid cells. Furthermore, glucocorticoids prevent Trp53 activation in Rps19-deficient cells- in a disease-specific manner. Dissecting the therapeutic mechanisms behind glucocorticoid treatment of DBA provides indispensible insight into DBA pathogenesis. Identifying mechanisms important for DBA treatment also enables development of more disease-specific treatments of DBA.

Published
2015

37. Lentiviral Vectors with Cellular Promoters Correct Anemia and Lethal Bone Marrow Failure in a Mouse Model for Diamond-Blackfan Anemia

Author

Debnath, Shubhranshu, Jaako, Pekka, Siva, Kavitha, Rothe, Michael, Chen, Jun, Dahl, Maria, Gaspar, H. Bobby, Flygare, Johan, Schambach, Axel, and Karlsson, Stefan

Abstract

Diamond-Blackfan anemia is a congenital erythroid hypoplasia and is associated with physical malformations and a predisposition to cancer. Twenty-five percent of patients with Diamond-Blackfan anemia have mutations in a gene encoding ribosomal protein S19 (RPS19). Through overexpression of RPS19 using a lentiviral vector with the spleen focus-forming virus promoter, we demonstrated that the Diamond-Blackfan anemia phenotype can be successfully treated in Rps19-deficient mice. In our present study, we assessed the efficacy of a clinically relevant promoter, the human elongation factor 1α short promoter, with or without the locus control region of the β-globin gene for treatment of RPS19-deficient Diamond-Blackfan anemia. The findings demonstrate that these vectors rescue the proliferation defect and improve erythroid development of transduced RPS19-deficient bone marrow cells. Remarkably, bone marrow failure and severe anemia in Rps19-deficient mice was cured with enforced expression of RPS19 driven by the elongation factor 1α short promoter. We also demonstrate that RPS19-deficient bone marrow cells can be transduced and these cells have the capacity to repopulate bone marrow in long-term reconstituted mice. Our results collectively demonstrate the feasibility to cure RPS19-deficient Diamond-Blackfan anemia using lentiviral vectors with cellular promoters that possess a reduced risk of insertional mutagenesis.

Published
2017
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39. Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes ...

Author

Kilpeläinen, TuomasO., Lakka, TimoA., Laaksonen, DavidE., Mager, Ursula, Salopuro, Titta, Kubaszek, Agata, Todorova, Boryana, Laukkanen, Olli, Lindström, Jaana, Eriksson, JohanG., Hämäläinen, Helena, Aunola, Sirkka, Ilanne-Parikka, Pirjo, Keinänen-Kiukaanniemi, Sirkka, Tuomilehto, Jaako, Laakso, Markku, and Uusitupa, Matti

Subjects
DIABETES, CARBOHYDRATE intolerance, HEREDITY, ANALYSIS of variance
Abstract

Abstract: Single nucleotide polymorphisms (SNPs) in the ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL genes were associated with the conversion from impaired glucose tolerance (IGT) to type 2 diabetes mellitus (T2D) in the Finnish Diabetes Prevention Study (DPS). In this study, we determined whether polymorphisms in these genes modified the effect of changes in physical activity (PA) on the risk of T2D in the DPS. Moreover, we assessed whether the polymorphisms modified the effect of changes in PA on changes in measures of body fat, serum lipids, and blood pressure during the first year of the follow-up of the DPS. Overweight subjects with IGT (n = 487) were followed for an average of 4.1 years, and PA was assessed annually with a questionnaire. The interactions of the polymorphisms with changes in total and moderate-to-vigorous PA on the conversion to T2D during the 4.1-year follow-up were assessed using Cox regression with adjustments for the other components of the intervention (dietary changes, weight reduction). Univariate analysis of variance was used to assess interactions on changes in continuous variables during the first year of the follow-up. No interaction between the polymorphisms and PA on the conversion to T2D was found. The Leu72Met (rs696217) polymorphism in GHRL modified the effect of moderate-to-vigorous PA on changes in weight and waist circumference, the −501A/C (rs26802) polymorphism in GHRL modified the effect of total and moderate-to-vigorous PA on change in high-density lipoprotein cholesterol, and the Lys109Arg (rs1137100) polymorphism in LEPR modified the effect of total PA on change in blood pressure. In conclusion, genetic variation may modify the magnitude of the beneficial effects of PA on characteristics of the metabolic syndrome in persons with IGT. [Copyright &y& Elsevier]

Published
2008
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40. Hematopoietic Stem Cells Are Intrinsically Protected against MLL-ENL-Mediated Transformation

Author

Ugale, Amol, Norddahl, Gudmundur L., Wahlestedt, Martin, Säwén, Petter, Jaako, Pekka, Pronk, Cornelis Jan, Soneji, Shamit, Cammenga, Jörg, and Bryder, David

Abstract

Studies of developmental pathways of hematopoietic stem cells (HSCs) have defined lineage relationships throughout the blood system. This is relevant to acute myeloid leukemia (AML), where aggressiveness and therapeutic responsiveness can be influenced by the initial stage of transformation. To address this, we generated a mouse model in which the mixed-lineage leukemia/eleven-nineteen-leukemia (MLL-ENL) transcription factor can be conditionally activated in any cell type. We show that AML can originate from multiple hematopoietic progenitor subsets with granulocytic and monocytic potential, and that the normal developmental position of leukemia-initiating cells influences leukemic development. However, disease failed to arise from HSCs. Although it maintained or upregulated the expression of target genes associated with leukemic development, MLL-ENL dysregulated the proliferative and repopulating capacity of HSCs. Therefore, the permissiveness for development of AML may be associated with a narrower window of differentiation than was previously appreciated, and hijacking the self-renewal capacity of HSCs by a potent oncogene is insufficient for leukemic development.

Published
2014
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41. Dietary L-leucine improves the anemia in a mouse model for Diamond-Blackfan anemia

Author

Jaako, Pekka, Debnath, Shubhranshu, Olsson, Karin, Bryder, David, Flygare, Johan, and Karlsson, Stefan

Abstract

Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by a functional haploinsufficiency of genes encoding for ribosomal proteins. Recently, a case study reported a patient who became transfusion-independent in response to treatment with the amino acid L-leucine. Therefore, we have validated the therapeutic effect of L-leucine using our recently generated mouse model for RPS19-deficient DBA. Administration of L-leucine significantly improved the anemia in Rps19-deficient mice (19% improvement in hemoglobin concentration; 18% increase in the number of erythrocytes), increased the bone marrow cellularity, and alleviated stress hematopoiesis. Furthermore, the therapeutic response to L-leucine appeared specific for Rps19-deficient hematopoiesis and was associated with down-regulation of p53 activity. Our study supports the rationale for clinical trials of L-leucine as a therapeutic agent for DBA.

Published
2012
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42. Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia

Author

Jaako, Pekka, Flygare, Johan, Olsson, Karin, Quere, Ronan, Ehinger, Mats, Henson, Adrianna, Ellis, Steven, Schambach, Axel, Baum, Christopher, Richter, Johan, Larsson, Jonas, Bryder, David, and Karlsson, Stefan

Abstract

Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by a functional haploinsufficiency of genes encoding for ribosomal proteins. Among these genes, ribosomal protein S19 (RPS19) is mutated most frequently. Generation of animal models for diseases like DBA is challenging because the phenotype is highly dependent on the level of RPS19 down-regulation. We report the generation of mouse models for RPS19-deficient DBA using transgenic RNA interference that allows an inducible and graded down-regulation of Rps19. Rps19-deficient mice develop a macrocytic anemia together with leukocytopenia and variable platelet count that with time leads to the exhaustion of hematopoietic stem cells and bone marrow failure. Both RPS19 gene transfer and the loss of p53 rescue the DBA phenotype implying the potential of the models for testing novel therapies. This study demonstrates the feasibility of transgenic RNA interference to generate mouse models for human diseases caused by haploinsufficient expression of a gene.

Published
2011
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44. Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture

Author

Singbrant, Sofie, Karlsson, Göran, Ehinger, Mats, Olsson, Karin, Jaako, Pekka, Miharada, Ken-ichi, Stadtfeld, Matthias, Graf, Thomas, and Karlsson, Stefan

Abstract

Numerous publications have described the importance of bone morphogenetic protein (BMP) signaling in the specification of hematopoietic tissue in developing embryos. Here we investigate the full role of canonical BMP signaling in both adult and fetal liver hematopoiesis using conditional knockout strategies because conventional disruption of components of the BMP signaling pathway result in early death of the embryo. By targeting both Smad1and Smad5, we have generated a double-knockout mouse with complete disruption of canonical BMP signaling. Interestingly, concurrent deletion of Smad1and Smad5results in death because of extrahematopoietic pathologic changes in the colon. However, Smad1/Smad5-deficient bone marrow cells can compete normally with wild-type cells and display unaffected self-renewal and differentiation capacity when transplanted into lethally irradiated recipients. Moreover, although BMP receptor expression is increased in fetal liver, fetal liver cells deficient in both Smad1 and Smad5 remain competent to long-term reconstitute lethally irradiated recipients in a multilineage manner. In conclusion, canonical BMP signaling is not required to maintain either adult or fetal liver hematopoiesis, despite its crucial role in the initial patterning of hematopoiesis in early embryonic development.

Published
2010
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45. Differences in Aneurysm and Patient Characteristics Between Cohorts of Finnish and Dutch Patients With Subarachnoid Hemorrhage

Author

Munster, Caspar E.P. van, von und zu Fraunberg, Mikael, Rinkel, Gabriel J.E., Rinne, Jaako, Koivisto, Timo, and Ronkainen, Antti

Abstract

The high incidence of aneurysmal subarachnoid hemorrhage (aSAH) in Finland may be related to genetic or environmental factors, which may also influence patient and aneurysm characteristics. We compared these characteristics in 2 cohorts in Finland (Kuopio) and the Netherlands (Utrecht).

Published
2008
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46. Dominant negative mutations in the C‐propeptide of COL2A1 cause platyspondylic lethal skeletal dysplasia, torrance type, and define a novel subfamily within the type 2 collagenopathies

Author

Zankl, Andreas, Neumann, Luitgard, Ignatius, Jaako, Nikkels, Peter, Schrander‐Stumpel, Connie, Mortier, Geert, Omran, Heymut, Wright, Michael, Hilbert, Katja, Bonafé, Luisa, Spranger, Juergen, Zabel, Bernhard, and Superti‐Furga, Andrea

Abstract

Platyspondylic lethal skeletal dysplasia (PLSD) Torrance type (PLSD‐T) is a rare skeletal dysplasia characterized by platyspondyly, brachydactyly, and metaphyseal changes. Generally a perinatally lethal disease, a few long‐term survivors have been reported. Recently, mutations in the carboxy‐propeptide of type II collagen have been identified in two patients with PLSD‐T, indicating that PLSD‐T is a type 2 collagen‐associated disorder. We studied eight additional cases of PLSD‐T and found that all had mutations in the C‐propeptide domain of COL2A1. The mutational spectrum includes missense, stop codon and frameshift mutations. All non‐sense mutations were located in the last exon, where they would escape non‐sense‐mediated RNA‐decay. We conclude that PLSD‐T is caused by mutations in the C‐propeptide domain of COL2A1, which lead to biosynthesis of an altered collagen chain (as opposed to a null allele). Similar mutations have recently been found to be the cause of spondyloperipheral dysplasia, a non‐lethal dominant disorder whose clinical and radiographical features overlap those of the rare long‐term survivors with PLSD‐T. Thus, spondyloperipheral dysplasia and PLSD‐T constitute a novel subfamily within the type II collagenopathies, associated with specific mutations in the C‐propeptide domain and characterized by distinctive radiological features including metaphyseal changes and brachydactyly that set them apart from other type 2 collagenopathies associated with mutations in the triple‐helical domain of COL2A1. The specific phenotype of C‐propeptide mutations could result from a combination of diminished collagen fibril formation, toxic effects through the accumulation of unfolded collagen chains inside the chondrocytes, and alteration of a putative signaling function of the carboxy‐propeptide of type 2 collagen. © 2005 Wiley‐Liss, Inc.

Published
2005
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47. Ethanol intoxication reduces, whereas ethanol withdrawal transiently enhances, production of the neural progenitor cells in the adult mouse dentate gyrus

Author

Jaako, K., Zharkovsky, T., Kaasik, A., and Zharkovsky, A.

Abstract

The hippocampus is one of the brain areas where neurogenesis persists during adulthood. To determine whether chronic ethanol administration affects production of the new cells in the dentate gyrus adult mice received ethanol via the inhalation route for 4 weeks and newly born cells were determined after administration of the proliferation marker bromodeoxyuridine (BrdU). An inhibition of the generation of the new cells at the end of ethanol intoxication was observed, whereas ethanol withdrawal induced a transient increase in the number of dividing cells in the dentate gyrus. The differentiation of the newly born cells into mature calbindin-positive neurons during ethanol intoxication or withdrawal was retarded. Although the functional significance of the observed changes is not known, we suggest that retardation of the differentiation of the new cells following ethanol administration might have an impact on the ethanol-induced impairment of hippocampal functions.

Published
2003
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48. Is a Dissection Balloon Beneficial in Bilateral, Totally Extraperitoneal, Endoscopic Hernioplasty? A Randomized, Prospective, Multicenter Study

Author

Bringman, Sven, Ek, sa, Haglind, Eva, Heikkinen, Timo-Jaako, Kald, Anders, Kylberg, Fredrik, Ramel, Stig, Wallon, Conny, and Anderberg, Bo

Abstract

Laparoscopic hernioplasty has been criticized because of its technical complexity and increased costs. Disposable dissection balloons can be used to gain the initial working space in totally extraperitoneal endoscopic (TEP) hernioplasty, but this increases its cost. Forty-four men with bilateral, primary or recurrent inguinal hernias were randomized to undergo TEP with or without dissection balloon. There were two conversions to transabdominal preperitoneal hernioplasty, or open herniorrhaphy, in the group with balloon and four in the group without balloon. There was no difference in the postoperative morbidity or operation time between the two groups, and there were no major complications in either group. The recurrence rate was 4.3 in the group with the balloon and 7.1 in the group without the balloon. There were no statistically significant differences between the groups. Although our study population is too small to detect small differences between the groups, it seems that the use of a dissection balloon is not beneficial in a bilateral TEP.

Published
2001

50. Prenatal diagnosis of non‐ketotic hyperglycinaemia: enzymatic diagnosis in 28 families and DNA diagnosis detecting prevalent Finnish and Israeli–Arab mutations

Author

Kure, Shigeo, Rolland, Marie‐Odile, Leisti, Jaako, Mandel, Hanna, Sakata, Yoshiyuki, Tada, Keiya, Matsubara, Yoichi, and Narisawa, Kuniaki

Abstract

Prenatal diagnosis for non‐ketotic hyperglycinaemia (NKH) was performed by enzymatic analysis of chorionic villus samples in 28 families and by DNA analysis in two families. In 26 families, enzymatic analysis of the glycine cleavage multi‐enzyme system (GCS) yielded an unambiguous diagnosis; inconclusive results in two families were due to borderline GCS activitiy. We analysed a second chorionic sample in these two families. In one case, GCS activity was normal in the second specimen, and the baby did not have NKH. In the other case, we again found extremely low GCS activity in the second specimen, but a healthy baby was born. The cause of this false‐positive result is unknown. Molecular analysis of NKH has identified two prevalent mutations to date; the S564I mutation in a gene encoding the P‐protein, a component of the GCS, in a Finnish population, and the H42R mutation in a gene encoding the T‐protein in the Israeli–Arab population. These prevalent mutations allow us to obtain unambiguous prenatal diagnoses in both Finnish and Israeli–Arab families. GCS activity in samples from a Finnish family demonstrated a good agreement with DNA analysis, but the fetus of the Israeli–Arab family had an upper limit activity of the affected range, suggesting an advantages for DNA analysis. Copyright © 1999 John Wiley & Sons, Ltd.

Published
1999
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