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353 results on '"JUREWICZ, JOANNA"'

26. Assessment of Exposure to Synthetic Pyrethroids with the Use of Silicone Wristbands and Biomonitoring of Urinary Metabolites: A Pilot Study

Author

Wacławik, Małgorzata, Skwarło, Dominika, Jurewicz, Joanna, and Wielgomas, Bartosz

Abstract

A novel approach to assess exposure to synthetic pyrethroids includes the use of silicone wristbands (WBs). In this pilot study completed on (n= 24) volunteers, comprising a week-long sampling period, paired urine samples (metabolites), and WBs (native compounds) were analyzed. This study employed a newly developed method for the determination of six pyrethroids in WBs. Permethrin was the most frequently detected compound (58.3%) in WBs and its geometric mean concentration was 79.64 ng/g. The most frequently detected metabolite in urine was 3-phenoxybenzoic acid (3-PBA) (68.06%). The geometric mean concentrations of urinary pyrethroid biomarkers varied from 0.21 ng/mL for 3-PBA to 0.08 ng/mL for cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane carboxylic acid (DBCA). Higher concentrations of urinary metabolites (3-PBA, DBCA, cis-DCCA, and trans-DCCA) and permethrin in WBs were detected in study participants who reported pest control in occupied buildings within the last 5 years. The concentrations of 3-PBA, cis-DCCA, trans-DCCA, and permethrin were greater among people using insecticides in their homes. Both the ownership of pets and the use of antiparasitic veterinary drugs also resulted in significantly higher concentrations of metabolites in urine and permethrin in WBs. Silicone wristbands turned out to be a promising tool that may supplement qualitative and quantitative assessment of external exposure and the detection of key sources of pyrethroids in a minimally invasive way. Although our study is only a pilot one with a small number of participants, both urine analysis and wristbands independently allowed for the identification of the same exposure predictors, thereby documenting a certain potential for the practical application of WBs in exposure assessment.

Published
2024
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35. REPRO_PL-Polish Mother and Child Cohort-Exposure, Health Status, and Neurobehavioral Assessments in Adolescents-Design and Cohort Update

Author

Ministerio de Ciencia e Innovación (España), 0000-0003-4527-6513, 0000-0002-9201-9328, 0000-0001-7162-2569, 0000-0001-9645-0134, 0000-0001-6903-0732, 0000-0002-3212-2307, 0000-0002-8042-406X, Janc, Magdalena, Jankowska, Agnieszka, Weteska, Monika, Brzozowska, Agnieszka, Hanke, Wojciech, Jurewicz, Joanna, Garí, Mercè, Polańska, Kinga, Jerzyńska, Joanna, Ministerio de Ciencia e Innovación (España), 0000-0003-4527-6513, 0000-0002-9201-9328, 0000-0001-7162-2569, 0000-0001-9645-0134, 0000-0001-6903-0732, 0000-0002-3212-2307, 0000-0002-8042-406X, Janc, Magdalena, Jankowska, Agnieszka, Weteska, Monika, Brzozowska, Agnieszka, Hanke, Wojciech, Jurewicz, Joanna, Garí, Mercè, Polańska, Kinga, and Jerzyńska, Joanna

Abstract

Early life is a crucial window of opportunity to improve health across the life course. The prospective cohort study design is the most adequate to evaluate the longitudinal effects of exposure, the notification of changes in the exposure level and evaluation of the simultaneous impact of various exposures, as well as the assessment of several health effects and trajectories throughout childhood and adolescence. This paper provides an overview of the Polish Mother and Child cohort (REPRO_PL), with particular emphasis on Phase IV of this study. REPRO_PL is conducted in central Europe, where such longitudinal studies are less frequently implemented. In this population-based prospective cohort, which was established in 2007, three phases covering pregnancy (I), early childhood (II), and early school age (III) periods have already been completed. Phase IV gives a uniform opportunity to follow-up children during adolescence in order to evaluate if the consequences of prenatal and early postnatal exposures still persist at the age of 14. Moreover, we will be able to investigate the associations between simultaneous exposures to a broad spectrum of environmental factors, adolescents' health and neurobehavioral outcomes, and their trajectories within life, which is a novel framework of high scientific, public health and clinical priority.

Published
2022

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