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This paper establishes a microchannel model based on the pore scale distribution characteristics of natural cores from Daqing Oilfield. It considers the deformation and flow characteristics of the dispersed and continuous phases in the heterogeneous system， builds a flow model by the phase field method， and solves it by the finite element method. The paper also simulates the generation of dispersed phase particles in the microchannel， realizes particle sorting， and studies the effect of the matching coefficient and pore-throat ratio on the plugging performance of particles in the microscopic pore-throat structure. The results show that when the particles are elastically plugged in the microscopic pore-throat structure， the pressure at the entrance of the pore throat changes periodically with the migration of the particles through the pore throat. The optimal matching coefficient between the particles and the pore throat is ［1.0， 1.4）. In this interval， the particles can be temporarily plugged at the entrance of the pore throat and recover their original shape after deformation and migration through the pore throat. When the pore diameter is the same， a larger matching coefficient and pore-throat ratio indicate greater pressure of particles through the pore throat， and larger particle size reflects a smaller critical value of particles through the pore throat.

Background and Purpose: Primary Ewing sarcoma of the thoracic wall (PEST) is a rare extraosseous Ewing sarcoma that occurs in the chest wall or thoracic cavity with a short survival, poor prognosis and a high rate of recurrence. Early diagnosis and treatment are the best way to prolong survival time since the cause of PEST is not clear. This study aimed to explore the clinicopathologic characteristics, diagnosis and treatment of PEST to improve clinical understanding of this disease. Methods: A total of 21 cases with PEST were treated at The First Affiliated Hospital of Soochow University, and reviews were published from 2018 to 2023. Clinical data, pathological features, treatment and follow-up of the patients were analyzed respectively. The survival was from the start of treatment to the death of the patient or the end of the follow-up. Cumulative survival was estimated by Kaplan-Meier method. Results: A total of 21 cases with PEST (male/female ratio, 13:8; sites of left/right chest ratio, 6:15; median age, 20 years; mean age, 28 years; median diameter of the tumor, 8.0 cm; mean diameter of the tumor, 18.1 cm) met the inclusion criteria. 65.2% of the patients presented with the pain in the ipsilateral thoracic and abdominal area. In 47.1% of cases, the ipsilateral ribs were invaded with pleural effusion. Pathological morphology microscopy showed most tumor cells were tightly packed or lobular distribution of small blue round cells. In immunohistochemistry, CD99 and vimentin were positive in 100% and 80% cases respectively while neurogenic markers were expressed to varying degrees. EWSR1 separated signal was found by fluorescence in situ hybridization (FISH), and the EWSR1-FLI1 fusion was detected by next-generation sequencing (NGS) in two cases at our hospital. Two cases received neoadjuvant chemotherapy, 10 patients received chemotherapy and radiotherapy after operation, 5 cases were treated with radiotherapy only, 1 case received surgery only, and 3 cases had no surgical data. A total of 14 cases were followed up for 3-38 month while 7 cases were lost to visit. Cumulative survival correlates with age at disease. The mean survival time was 19.98 months, and the median survival time was 13.00 months. Conclusion: Young males, right chest and the mass larger than 8 cm are more often found. Most cases can be initially diagnosed using histopathology and immunohistochemical markers. FISH or NGS of the EWSR1 gene test are a highly accurate method for diagnosis. The prognosis of PEST is extremely poor, and the cumulative survival rate is negatively correlated with the age of onset. Surgery, radiotherapy and chemotherapy are the main treatments for this disease.

In this study, the mechanical properties of non-crimp fabric (NCF) composite laminates under low-velocity impact and compression after impact (CAI) tests were studied by Scanning electron microscopy (SEM) and Digital image correlation (DIC) techniques. The impact response under different impact times, impact angles, and impact distance is studied. Similarly, in CAI test, DIC technique is used to reveal the whole process of NCF composite compression failure, and SEM is used to reveal the microscopic failure form. The experimental results show that the impact damage process of NCF composites has strong directivity. The concrete manifestation is that the internal failure will extend along the paving direction at the failure layer. The peak load generated under 20 J impact energy is about 1/2 of that under 40 J impact energy. The impact distance is one of the important factors affecting the coupling effect of multiple impacts, and the impact angle has little effect on the internal damage extension. The proportion of internal damage area also supports the relevant view, that is, the average difference in the proportion of internal damage area under different impact distance is about 5%, while the average difference in the proportion of internal damage area under different impact angles is about 3%. During the compression process, the main failure mode is shear failure and the failure mode is brittle fracture. The oblique fracture occurs only when the oblique is 45° and the impact distance is large (50 mm). The impact angle has little effect on the residual compression performance of NCF.

Fluopimomide is a novel acid amide fungicide registered for the control of many plant pathogens. In the present study, the effects of soil-treated fluopimomide on soil micro biomass, disease incidence, plant growth, soil enzyme activity, and marketable yield of tomato (Solanum lycopersicum L.) were investigated via field trial. In addition, the application prospect in China was also evaluated. In the experiment, five treatments with three replications and a randomized complete block design were followed. The treatments were: furrow application of fluopimomide (25% suspension concentrate, SC) at the dosage of 375, 750, and 1,500 g ha−1, which was recommended, double recommended, and quadruple recommended dosages, respectively. Besides, common control fungicide fluopicolide (5% SC) furrow was applied at recommended application dosages of 750 mL ha−1, and a non-treated control was also undertaken. Results indicated that fluopimomide exhibited no effects on the amount of soil bacteria and actinomycetes, and its inhibition effect on fungi amount could be recovered at 60 days after treatment (DAT). With the recommended application dosage, fluopimomide could efficiently reduce the number of plant pathogens in soil by 79.56–85.80%, significantly reduce the disease incidences in tomato plants by 80.00–88.24%, and improve plant height by 13.25–24.05% and marketable yield by 16.88%. Furthermore, soil enzymes exhibited a complex response to fluopimomide, and AOB and nifH gene copy numbers were increased by the double and quadruple recommended dosage of fluopimomide. Based on the above results, fluopimomide could be recommended as an efficient fungicide for the tomato field.

With mine drainage and activities, the hydrogeochemical environments has greatly changed in Kongjiagou coalmine, Sichuan Province, southwest China. This study aimed to summarize an ideal model of coalmine hydrogeochemical zonation and evolution. In total, 24 groundwater samples from different depth were collected to analyze their components, with the combination of methods such as ion sources, normalization index, ions ratios, cation exchange and inverse modeling. The hydrogeochemical formation main factor was water–rock reactions and more weathering by sulfuric acid. Dissolution and pyrite oxidation were the main sources of , whereas carbonate weathering was the dominant source of . The vertical extent could be distinguished to three zones by mean and standard deviation of burial depth. The normalization index, ions ratios, cation exchange and water types exhibited clear vertical zonation. In shallow groundwater, dissolution led to a Ca- type water and overall stable concentrations of ions. Redox reactions in the middle region have caused significant increases in the total dissolved solids (TDS) and and a considerable reduction in pH; hence, Ca + Mg-SO4 + HCO3 became the dominant type. Re-dissolution and cation exchange played important roles at depth and caused the pH and TDS to increase slowly. The , Ca2+, and Mg2+ concentrations increased rapidly, whereas the concentration remained basically unchanged, and the water type was either Ca + Mg-HCO3 + SO4 or Na-HCO3 + SO4. This study will be of great significance to coalmine safety production and water environments protection. HIGHLIGHTS Distinguished vertical zonation based on mean and standard deviation of burial depth.; Introduced ions normalization index for hydrogeochemical analysis.; PHREEQC was used to calculate the amount transferred from shallow to deep.; The main reactions from shallow to deep were dissolution, redox, re-dissolution and cation exchange.; Summarized an ideal vertical zoning model and mechanism of coal mine hydrogeochemically.;

Hyperglycemia-induced endothelial inflammation participates in the pathogenesis of cardiovascular complications in diabetics. Previous studies showed that protein tyrosine phosphatase 1B (PTP1B) and ETS proto-oncogene 1 (ets1) are involved in hyperglycemia-induced endothelial inflammation. In this study, we hypothesized that ets1 modulates PTP1B expression, thus playing a crucial role in hyperglycemia-induced vascular endothelial inflammation. Our results indicated that high glucose increases monocyte/endothelial adhesion, vascular cell adhesion molecule-1 (VCAM-1) expression and p65 phosphorylation in human umbilical vein endothelial cells (HUVECs). Moreover, high glucose-mediated endothelial inflammation is reversed by PTP1B silencing. In addition, high glucose increases ets1 expression in HUVECs. Ets1 silencing reverses high glucose-mediated endothelial inflammation. Furthermore, the effect of ets1 overexpression is similar to that of high glucose treatment, which is counteracted by si-PTP1B. The results from ChIP assays indicated that ets1 occupies the PTP1B promoter region. Ets1 overexpression enhances PTP1B promoter activity, which is disappeared after specific binding site mutation. In vivo experiments demonstrated that the expressions of VCAM-1, PTP1B, and ets1, as well as the phosphorylation of p65 are augmented in the aorta of diabetic rats. In conclusion, ets1 contributes to hyperglycemia-mediated endothelial inflammation via upregulation of PTP1B expression.

The treatment of oral cancer patients mainly involves surgery in combination with radiotherapy and che⁃ motherapy. This paper reviews the clinical features of perioperative patients with oral cancer, including oral flora imbal⁃ ance, oral complications after radiotherapy and chemotherapy, the presence of oral incisions (and flaps), special dietary needs, and airway management. In connection with the above characteristics, this article analyzes the necessity of three aspects of oral care to improve the patient􀆳s comfort and prevent pulmonary and surgical site infections, with the goal of providing a reference for oral care research on patients undergoing oral cancer surgery and laying a foundation for the construction of comprehensive oral care programs during the perioperative period for patients with oral cancer.

Technology is widely involved across the learning environment including its integration into teaching English as a foreign language (EFL); however, few studies have explored EFL teachers' perceptions of technological pedagogical content knowledge (TPACK). This study investigates how EFL teachers perceive and self-evaluate knowledge of content (CK), pedagogy (PK), and technology (TK), the interplay of these with each other (TPACK), and the underlying influential factors for TPACK construction. The data were gathered in China from an online survey (n = 64) comprising 35 items on the TPACK components, and self-evaluation by nine survey participants of their TPACK in follow-up interviews. WeChat, the most popular social media App in China, was utilised as the data collection tool. The survey reveals teachers' strong beliefs in the value of PK, CK and PCK and their positive beliefs about technological applications in EFL instruction. Consistent with these results, interviewees' self-evaluation of TPACK demonstrates that they felt a high level of confidence in CK, PK and PCK but relatively less confidence when technology was integrated despite commonly applying technology to instruction. Influential factors include: 1) contextual factors; 2) knowledge of students; 3) demographic background; and 4) availability of quality training. Decision-makers' financial support and policy-making, technological training in the integration of CK and/or PK, and a collaborative learning strategy are recommended.