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239 results on '"JENSENIUS, MOGENS"'

1. Availability and costs of medicines for the treatment of tuberculosis in Europe

Author

Hasan Hafizi, Khachatryan, Naira, Aroyan, Harut, Kabasakalyan, Eduard, Knappik, Michael, Skrahina, Alena, Klimuk, Dzmitry, Nikolenka, Alena, Muylle, Inge, Milanov, Vladimir, Velkovska, Desislava, Tarinska, Neli, Bachiyska, Elizabeta, Jankovic, Mateja, Pieridou, Despo, Adamide, Tonia, Nicolaou, Nicos, Vasakova, Martina, Sukholytka, Mariia, Kopeckà, Emilia, Folkvardsen, Dorte Bek, Svensson, Erik, Danilovits, Manfred, Kummik, Tiina, Vasankari, Tuula, Fréchet-Jachym, Mathilde, Nahmiash, Audrey, Togonidze, Tamar, Avaliani, Zaza, Kinkladze, Inga, Aspindzelashvili, Rusudan, Bichashvili, Teona, Losaberidze, Gulnazi, Merabishvili, Tsitsino, Kalsdorf, Barbara, Manika, Katerina, Tsiakitzis, Karyofyllis, Bakos, Agnes, Ægisdóttir, Tinna Rán, Michelsen, Guðrún Svanhvít, Karlsdóttir, Kristín, McLaughlin, Anne-Marie, Fitzgibbon, Margaret, Chemtob, Daniel, Codecasa, Luigi R., Ferrarese, Maurizio, Torri, Stefania, Gjocaj, Majlinda, Kuksa, Liga, Davidaviciene, Edita, Wirtz, Gil, Perrin, Monique, Asciak, Analita Pace, Chesov, Dumitri, de Lange, Wiel, Akkerman, Onno, Poposka, Biljana Ilievska, Mack, Ulrich, Jensenius, Mogens, Kvalvik, Lajla, Mengshoel, Anne Torunn, Kruczak, Katarzyna, Duarte, Raquel, Ribeiro, Nadine, Ibraim, Elmira, Kaluzhenina, Anna, Barkanova, Olga, Pesut, Dragica, Solovic, Ivan, Svetina, Petra, Souza-Galvão, Maria-Luiza de, Millet, Joan-Pau, Casas, Xavi, Vives, Montserrat, Bruchfeld, Judith, Dalemo, Paulina, Jonsson, Jerker, Aeschbacher, Katrin, Keller, Peter, Özkara, Seref, Tiberi, Simon, Chen, Christabelle, Terleeva, Yana, Dudnyk, Andrii, Günther, Gunar, Guglielmetti, Lorenzo, Leu, Claude, Lange, Christoph, and van Leth, Frank

Published
2023
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2. Rumpert ekinokokkcyste

Author

Riis, Åse Garløv, primary, Jensenius, Mogens, primary, Greve, Ole Jacob, primary, Lier, Tore, primary, Nylenna, Øyvind, primary, and Yaqub, Sheraz, primary

Published
2024
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3. Alveolær ekinokokkose.

Author

JENSENIUS, MOGENS, MØRCH, KRISTINE, YAQUB, SHERAZ, HALVORSEN, DAG SEEGER, REIMS, HENRIK MIKAEL, BJÖRK, IDA GABRIELLA, RØSOK, BÅRD INGVALD, OLTMANNS, GUNNAR, HELBAK, KIRSTI, ØINES, ØIVIND, and LIER, TORE

Published
2024
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4. Ex-situ liver resection for complex Echinococcus multilocularis infection: a case report.

Author

Kjeseth, Trond, Line, Pål-Dag, Khan, Ammar, Solheim, Jon M, Bjørk, Ida G, Sundal, Jon, Jensenius, Mogens, and Yaqub, Sheraz

Subjects
ECHINOCOCCUS multilocularis, VENA cava inferior, LIVER, HEPATIC veins, VENAE cavae
Abstract

Echinococcus multilocularis , the fox dwarf tapeworm, causes alveolar echinococcosis (AE), a critical and life-threatening condition. A radical surgical approach represents the only curative option. In this case study, we present a 37-year-old man diagnosed with extensive hepatic AE requiring ex-situ extended right-sided liver resection including the caudate lobe and retro-hepatic vena cava. The left liver segments were auto-transplanted with reconstruction of the left hepatic vein and an inferior vena cava graft. In the post-operative course, the patient developed a bile leak, which was successfully managed with endoscopic stent intervention. He was discharged after a three-week hospitalization. Medical treatment with albendazole was initiated preoperatively and continued postoperatively. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Availability and costs of medicines for the treatment of tuberculosis in Europe

Author

Günther, Gunar, Guglielmetti, Lorenzo, Leu, Claude, Lange, Christoph, van Leth, Frank, Hafizi, Hasan, Khachatryan, Naira, Aroyan, Harut, Kabasakalyan, Eduard, Knappik, Michael, Skrahina, Alena, Klimuk, Dzmitry, Nikolenka, Alena, Muylle, Inge, Milanov, Vladimir, Velkovska, Desislava, Tarinska, Neli, Bachiyska, Elizabeta, Jankovic, Mateja, Pieridou, Despo, Adamide, Tonia, Nicolaou, Nicos, Vasakova, Martina, Sukholytka, Mariia, Kopeckà, Emilia, Andersen, Åse Bengård, Folkvardsen, Dorte Bek, Svensson, Erik, Danilovits, Manfred, Kummik, Tiina, Vasankari, Tuula, Fréchet-Jachym, Mathilde, Nahmiash, Audrey, Togonidze, Tamar, Avaliani, Zaza, Kinkladze, Inga, Aspindzelashvili, Rusudan, Bichashvili, Teona, Losaberidze, Gulnazi, Merabishvili, Tsitsino, Kalsdorf, Barbara, Manika, Katerina, Tsiakitzis, Karyofyllis, Bakos, Agnes, Ægisdóttir, Tinna Rán, Michelsen, Guðrún Svanhvít, Karlsdóttir, Kristín, McLaughlin, Anne-Marie, Fitzgibbon, Margaret, Chemtob, Daniel, Codecasa, Luigi R., Ferrarese, Maurizio, Torri, Stefania, Gjocaj, Majlinda, Kuksa, Liga, Davidaviciene, Edita, Wirtz, Gil, Perrin, Monique, Asciak, Analita Pace, Chesov, Dumitri, de Lange, Wiel, Akkerman, Onno, Poposka, Biljana Ilievska, Mack, Ulrich, Jensenius, Mogens, Kvalvik, Lajla, Mengshoel, Anne Torunn, Kruczak, Katarzyna, Duarte, Raquel, Ribeiro, Nadine, Ibraim, Elmira, Kaluzhenina, Anna, Barkanova, Olga, Pesut, Dragica, Solovic, Ivan, Svetina, Petra, Souza-Galvão, Maria-Luiza de, Millet, Joan-Pau, Casas, Xavi, Vives, Montserrat, Bruchfeld, Judith, Dalemo, Paulina, Jonsson, Jerker, Aeschbacher, Katrin, Keller, Peter, Özkara, Seref, Tiberi, Simon, Chen, Christabelle, Terleeva, Yana, Dudnyk, Andrii, Health Economics and Health Technology Assessment, APH - Global Health, APH - Methodology, and Microbes in Health and Disease (MHD)

Subjects
Microbiology (medical), Evropa, Extensively Drug-Resistant Tuberculosis, Antitubercular Agents, Capacity building, 610 Medicine & health, MDR-TB, Mycobacterium tuberculosis - terapija z zdravili, Microbial Sensitivity Tests, Antimicrobial resistance, Medicines, Mycobacterium tuberculosis - drug therapy, SDG 3 - Good Health and Well-being, Tuberculosis, Multidrug-Resistant, Humans, Tuberculosis, tuberkuloza - terapija z zdravili, health care costs - drug therapy, Mycobacterium tuberculosis, General Medicine, END-TB strategy, udc:616-002, tuberculosis - drug therapy, Costs, stroški zdravstvene oskrbe - terapija z zdravili, Europe, Infectious Diseases, Availability of medicines
Abstract

Objectives: To evaluate the access to comprehensive diagnostics and novel antituberculosis medicines in European countries.Methods: We investigated the access to genotypic and phenotypic Mycobacterium tuberculosis drug susceptibility testing and the availability of antituberculosis drugs and calculated the cost of drugs and treatment regimens at major tuberculosis treatment centres in countries of the WHO European region where rates of drug-resistant tuberculosis are the highest among all WHO regions. Results were stratified by middle-income and high-income countries.Results: Overall, 43 treatment centres from 43 countries participated in the study. For WHO group A drugs, the frequency of countries with the availability of phenotypic drug susceptibility testing was as follows: (a) 75% (30/40) for levofloxacin, (b) 82% (33/40) for moxifloxacin, (c) 48% (19/40) for bedaquiline, and (d) 72% (29/40) for linezolid. Overall, of the 43 countries, 36 (84%) and 24 (56%) countries had access to bedaquiline and delamanid, respectively, whereas only 6 (14%) countries had access to rifapentine. The treatment of patients with extensively drug-resistant tuberculosis with a regimen including a carbapenem was available only in 17 (40%) of the 43 countries. The median cost of regimens for drug-susceptible tuberculosis, multidrug-resistant/rifampicin-resistant tuberculosis (shorter regimen, including bedaquiline for 6 months), and extensively drug-resistant tuberculosis (including bedaquiline, delamanid, and a carbapenem) were €44 (minimum–maximum, €15–152), €764 (minimum–maximum, €542–15152), and €8709 (minimum–maximum, €7965–11759) in middle-income countries (n = 12) and €280 (minimum–maximum, €78–1084), €29765 (minimum–maximum, €11116–40584), and €217591 (minimum–maximum, €82827–320146) in high-income countries (n = 29), respectively.Discussion: In countries of the WHO European region, there is a widespread lack of drug susceptibility testing capacity to new and repurposed antituberculosis drugs, lack of access to essential medications in several countries, and a high cost for the treatment of drug-resistant tuberculosis.

Published
2023

6. Tuberculosis incidence in foreign-born people residing in European countries in 2020

Author

Vasiliu, Anca, Köhler, Niklas, Altpeter, Ekkehardt, Ægisdóttir, Tinna Rán, Amerali, Marina, de Oñate, Wouter Arrazola, Bakos, Ágnes, D'Amato, Stefania, Cirillo, Daniela Maria, van Crevel, Reinout, Davidaviciene, Edita, Demuth, Irène, Domínguez, Jose, Duarte, Raquel, Günther, Gunar, Guthmann, Jean-Paul, Hatzianastasiou, Sophia, Holm, Louise Hedevang, Herrador, Zaida, Hribar, Urška, Huberty, Conny, Ibraim, Elmira, Jackson, Sarah, Jensenius, Mogens, Josefsdottir, Kamilla Sigridur, Koch, Anders, Korzeniewska-Kosela, Maria, Kuksa, Liga, Kunst, Heinke, Lienhardt, Christian, Mahler, Beatrice, Makek, Mateja Janković, Muylle, Inge, Normark, Johan, Pace-Asciak, Analita, Petrović, Goranka, Pieridou, Despo, Russo, Giulia, Rzhepishevska, Olena, Salzer, Helmut J. F., Marques, Marta Sá, Schmid, Daniela, Solovic, Ivan, Sukholytka, Mariya, Svetina, Petra, Tyufekchieva, Mariya, Vasankari, Tuula, Viiklepp, Piret, Villand, Kersti, Wallenfels, Jiri, Wesolowski, Stefan, Mandalakas, Anna-Maria, Martinez, Leonardo, Zenner, Dominik, Lange, Christoph, Vasiliu, Anca, Köhler, Niklas, Altpeter, Ekkehardt, Ægisdóttir, Tinna Rán, Amerali, Marina, de Oñate, Wouter Arrazola, Bakos, Ágnes, D'Amato, Stefania, Cirillo, Daniela Maria, van Crevel, Reinout, Davidaviciene, Edita, Demuth, Irène, Domínguez, Jose, Duarte, Raquel, Günther, Gunar, Guthmann, Jean-Paul, Hatzianastasiou, Sophia, Holm, Louise Hedevang, Herrador, Zaida, Hribar, Urška, Huberty, Conny, Ibraim, Elmira, Jackson, Sarah, Jensenius, Mogens, Josefsdottir, Kamilla Sigridur, Koch, Anders, Korzeniewska-Kosela, Maria, Kuksa, Liga, Kunst, Heinke, Lienhardt, Christian, Mahler, Beatrice, Makek, Mateja Janković, Muylle, Inge, Normark, Johan, Pace-Asciak, Analita, Petrović, Goranka, Pieridou, Despo, Russo, Giulia, Rzhepishevska, Olena, Salzer, Helmut J. F., Marques, Marta Sá, Schmid, Daniela, Solovic, Ivan, Sukholytka, Mariya, Svetina, Petra, Tyufekchieva, Mariya, Vasankari, Tuula, Viiklepp, Piret, Villand, Kersti, Wallenfels, Jiri, Wesolowski, Stefan, Mandalakas, Anna-Maria, Martinez, Leonardo, Zenner, Dominik, and Lange, Christoph

Abstract

Background: European-specific policies for tuberculosis (TB) elimination require identification of key populations that benefit from TB screening. Aim: We aimed to identify groups of foreign-born individuals residing in European countries that benefit most from targeted TB prevention screening. Methods: The Tuberculosis Network European Trials group collected, by cross-sectional survey, numbers of foreign-born TB patients residing in European Union (EU) countries, Iceland, Norway, Switzerland and the United Kingdom (UK) in 2020 from the 10 highest ranked countries of origin in terms of TB cases in each country of residence. Tuberculosis incidence rates (IRs) in countries of residence were compared with countries of origin. Results: Data on 9,116 foreign-born TB patients in 30 countries of residence were collected. Main countries of origin were Eritrea, India, Pakistan, Morocco, Romania and Somalia. Tuberculosis IRs were highest in patients of Eritrean and Somali origin in Greece and Malta (both > 1,000/100,000) and lowest among Ukrainian patients in Poland (3.6/100,000). They were mainly lower in countries of residence than countries of origin. However, IRs among Eritreans and Somalis in Greece and Malta were five times higher than in Eritrea and Somalia. Similarly, IRs among Eritreans in Germany, the Netherlands and the UK were four times higher than in Eritrea. Conclusions: Country of origin TB IR is an insufficient indicator when targeting foreign-born populations for active case finding or TB prevention policies in the countries covered here. Elimination strategies should be informed by regularly collected country-specific data to address rapidly changing epidemiology and associated risks.

Published
2023
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8. Area of exposure and treatment challenges of malaria in Eritrean migrants: a GeoSentinel analysis

Author

Schlagenhauf, Patricia, Grobusch, Martin P., Hamer, Davidson H., Asgeirsson, Hilmir, Jensenius, Mogens, Eperon, Gilles, Rothe, Camilla, Isenring, Egon, Fehr, Jan, Schwartz, Eli, Bottieau, Emmanuel, Barnett, Elizabeth D., McCarthy, Anne, Kelly, Paul, Schade Larsen, Carsten, van Genderen, Perry, Stauffer, William, Libman, Michael, and Gautret, Philippe

Published
2018
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11. Travel-related infections presenting in Europe: A 20-year analysis of EuroTravNet surveillance data

Author

Grobusch, Martin P, Weld, Leisa, Goorhuis, Abraham, Hamer, Davidson H, Schunk, Mirjam, Jordan, Sabine, Mockenhaupt, Frank P, Chappuis, François, Asgeirsson, Hilmir, Caumes, Eric, Jensenius, Mogens, Van Genderen, Perry JJ, Castelli, Francesco, López-Velez, Rogelio, Field, Vanessa, Bottieau, Emmanuel, Molina, Israel, Rapp, Christophe, Ménendez, Marta Díaz, Gkrania-Klotsas, Effrossyni, Larsen, Carsten S, Malvy, Denis, Lalloo, David, Gobbi, Federico, Florescu, Simin A, Gautret, Philippe, Schlagenhauf, Patricia, For EuroTravNet, Gkrania-Klotsas, Effrossyni [0000-0002-0930-8330], and Apollo - University of Cambridge Repository

Subjects
Geosentinel, Eurotravnet, Infectious diseases, Sentinel surveillance, travel
Abstract

Funder: Centers for Disease Control and Prevention, BACKGROUND: Disease epidemiology of (re-)emerging infectious diseases is changing rapidly, rendering surveillance of travel-associated illness important. METHODS: We evaluated travel-related illness encountered at EuroTravNet clinics, the European surveillance sub-network of GeoSentinel, between March 1, 1998 and March 31, 2018. FINDINGS: 103,739 ill travellers were evaluated, including 11,239 (10.8%) migrants, 89,620 (86.4%) patients seen post-travel, and 2,880 (2.8%) during and after travel. Despite increasing numbers of patient encounters over 20 years, the regions of exposure by year of clinic visits have remained stable. In 5-year increments, greater proportions of patients were migrants or visiting friends and relatives (VFR); business travel-associated illness remained stable; tourism-related illness decreased. Falciparum malaria was amongst the most-frequently diagnosed illnesses with 5,254 cases (5.1% of all patients) and the most-frequent cause of death (risk ratio versus all other illnesses 2.5:1). Animal exposures requiring rabies post-exposure prophylaxis increased from 0.7% (1998-2002) to 3.6% (2013-2018). The proportion of patients with seasonal influenza increased from zero in 1998-2002 to 0.9% in 2013-2018. There were 44 cases of viral haemorrhagic fever, most during the past five years. Arboviral infection numbers increased significantly as did the range of presenting arboviral diseases, dengue and chikungunya diagnoses increased by 2.6% and 1%, respectively. INTERPRETATION: Travel medicine must adapt to serve the changing profile of travellers, with an increase in migrants and persons visiting relatives and friends and the strong emergence of vector-borne diseases, with potential for further local transmission in Europe. FUNDING: This project was supported by a cooperative agreement (U50CK00189) between the Centers for Disease Control and Prevention to the International Society of Travel Medicine (ISTM) and funding from the ISTM and the Public Health Agency of Canada.

Published
2022
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15. Travel-Related Infection in European Travelers, EuroTravNet 2011

Author

Warne, Ben, Weld, Leisa H., Cramer, Jakob P., Field, Vanessa K., Grobusch, Martin P., Caumes, Eric, Jensenius, Mogens, Gautret, Philippe, Schlagenhauf, Patricia, Castelli, Francesco, Lalloo, David G., Ursing, Johan, Chappuis, François, von Sonnenburg, Frank, López-Vélez, Rogelio, Rapp, Christophe, Smith, Kitty C., Parola, Philippe, and Gkrania-Klotsas, Effrossyni

Published
2014
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16. Multicenter geosentinel analysis of rickettsial diseases in international travelers, 1996-2008

Author

Jensenius, Mogens, Davis, Xiaohong, von Sonnenburg, Frank, Schwartz, Eli, Keystone, Jay S., Leder, Karin, Lopez-Velez, Rogelio, Caumes, Eric, Cramer, Jakob P., Chen, Lin, and Parola, Philippe

Subjects
Travelers -- Analysis, Travel industry -- Analysis, Medical research -- Analysis, Medicine, Experimental -- Analysis
Abstract

Rickettsial diseases are acute and potentially severe zoonotic infections caused by obligate intracellular, gram-negative bacteria belonging to the order Rickettsiales. The taxonomy of Rickettsiales is complex and continues to be [...]

Published
2009

17. Multidrug-resistant tuberculosis imported into low-incidence countries—a GeoSentinel analysis, 2008–2020

Author

Eimer, Johannes, primary, Patimeteeporn, Calvin, additional, Jensenius, Mogens, additional, Gkrania-Klotsas, Effrossyni, additional, Duvignaud, Alexandre, additional, Barnett, Elizabeth D, additional, Hochberg, Natasha S, additional, Chen, Lin H, additional, Trigo-Esteban, Elena, additional, Gertler, Maximilian, additional, Greenaway, Christina, additional, Grobusch, Martin P, additional, Angelo, Kristina M, additional, Hamer, Davidson H, additional, Caumes, Eric, additional, and Asgeirsson, Hilmir, additional

Published
2021
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18. Travel-related infections presenting in Europe: a 20-year analysis of EuroTravNet surveillance data

Author

Grobusch, Martin P., Weld, Leisa, Goorhuis, Abraham, Hamer, Davidson H., Schunk, Mirjam, Jordan, Sabine, Mockenhaupt, Frank P., Chappuis, François, Asgeirsson, Hilmir, Caumes, Eric, Jensenius, Mogens, van Genderen, Perry J.J., Castelli, Francesco, López-Velez, Rogelio, Field, Vanessa, Bottieau, Emmanuel, Molina, Israel, Rapp, Christophe, Ménendez, Marta Díaz, Gkrania-Klotsas, Effrossyni, Larsen, Carsten S., Malvy, Denis, Lalloo, David, Gobbi, Federico, Florescu, Simin A., Gautret, Philippe, Schlagenhauf, Patricia, Stijnis, Kees, van Vugt, Michèle, Rothe, Camilla, von Sonnenburg, Frank, Vinnemeier, Christof, Ramharter, Michael, Equihua Martinez, Gabriela, Gertler, Maximilian, Eperon, Gilles, Ursing, Johan, Glans, Hedvig, Hægeland, Arnhild, Joof, Mona, Stuij, Corine, Odolini, Silvia, Tomasoni, Lina, Chamorro, Sandra, Lankester, Ted, Salvador, Fernando, Serre-Delcor, Nuria, Ficko, Cécile, Trigo, Elena, Warne, Benjamin, Jespersen, Sanne, Weijse, Christian, Duvignaud, Alexandre, Pistone, Thierry, Beeching, Nicholas, Beadsworth, Mike, Rodari, Paola, Moro, Lucia, Popescu, Corneliu P., Zaharia, Mihaela F., Javelle, Emilie, Parola, Philippe, Weber, Rainer, and Schmid-Stoll, Sabine

Subjects
wa_108
Abstract

Background\ud Disease epidemiology of (re-)emerging infectious diseases is changing rapidly, rendering surveillance of travel-associated illness important.\ud \ud Methods\ud We evaluated travel-related illness encountered at EuroTravNet clinics, the European surveillance sub-network of GeoSentinel, between March 1, 1998 and March 31, 2018.\ud \ud Findings\ud 103,739 ill travellers were evaluated, including 11,239 (10.8%) migrants, 89,620 (86.4%) patients seen post-travel, and 2,880 (2.8%) during and after travel. Despite increasing numbers of patient encounters over 20 years, the regions of exposure by year of clinic visits have remained stable. In 5-year increments, greater proportions of patients were migrants or visiting friends and relatives (VFR); business travel-associated illness remained stable; tourism-related illness decreased. Falciparum malaria was amongst the most-frequently diagnosed illnesses with 5,254 cases (5.1% of all patients) and the most-frequent cause of death (risk ratio versus all other illnesses 2.5:1). Animal exposures requiring rabies post-exposure prophylaxis increased from 0.7% (1998-2002) to 3.6% (2013-2018). The proportion of patients with seasonal influenza increased from zero in 1998-2002 to 0.9% in 2013-2018. There were 44 cases of viral haemorrhagic fever, most during the past five years. Arboviral infection numbers increased significantly as did the range of presenting arboviral diseases, Dengue and chikungunya diagnoses increased by 2.6% and 1%, respectively.\ud \ud Interpretation\ud Travel medicine must adapt to serve the changing profile of travellers, with an increase in migrants and persons visiting relatives and friends and the strong emergence of vector-borne diseases, with potential for further local transmission in Europe.\ud \ud Funding\ud This project was supported by a cooperative agreement (U50CK00189) between the Centers for Disease Control and Prevention to the International Society of Travel Medicine (ISTM) and funding from the ISTM and the Public Health Agency of Canada.

Published
2020

19. Cutaneous and mucocutaneous leishmaniasis in travellers and migrants: a 20-year GeoSentinel Surveillance Network analysis

Author

Boggild, Andrea, Caumes, Eric, Grobusch, Martin, Schwartz, Eli, Hynes, Noreen, Libman, Michael, Connor, Bradley, Chakrabarti, Sumontra, Parola, Philippe, Keystone, Jay, Nash, Theodore, Showler, Adrienne, Schunk, Mirjam, Asgeirsson, Hilmir, Hamer, Davidson, Kain, Kevin, Von Sonnenburg, Frank, Rothe, Camilla, Jordan, Sabine, Vinnemeier, Christof, Yansouni, Cedric, McCarthy, Anne, Jensenius, Mogens, Goorhuis, Abraham, Coyle, Christina, Mockenhaupt, Frank, Harms-Zwingengerger, Gundel, Leung, Daniel, Benson, Scott, Gautret, Philippe, Javelle, Emilie, Chappuis, François, Rapp, Christophe, Ficko, Cécile, Van Genderen, Perry, Glans, Hedvig, Beadsworth, Michael, Beeching, Nicholas, Castelli, Francesco, Matteelli, Alberto, Plewes, Katherine, Mirzanejad, Yazdan, López-Vélez, Rogelio, Chamorro, Sandra, Waggoner, Jesse, Wu, Henry, Leder, Karin, Torresi, Joseph, Bottieau, Emmanuel, Huits, Ralph, Chen, Lin, Bourque, Daniel, Alpern, Jonathan, Stauffer, William, Cahill, John, Wyler, Ben, Haulman, Jean, Terry, Anne, Licitra, Carmelo, Taylor, Ashley, Perret Perez, Cecilia, Weitzel, Thomas, Gkrania-Klotsas, Effrossyni, Warne, Ben, Schlagenhauf, Patricia, Weber, Rainer, Schade Larsen, Carsten, Wejse, Christian, Barnett, Elizabeth, Hochberg, Natasha, Barkati, Sapha, Vincelette, Jean, Molina, Israel, Malvy, Denis, Duvignaud, Alexandre, Mendelson, Marc, Parker, Salim, Johnston, Victoria, Field, Vanessa, Kuhn, Susan, Piyaphanee, Watcharapong, Silachamroon, Udomsak, Diaz-Menendez, Marta, Kelly, Paul, Blumberg, Lucille, de Frey, Albie, Pandey, Prativa, Amatya, Bhawana, Mavunda, Kunjana, Saio, Mauro, CHU Pitié-Salpêtrière [APHP], Department of Infectious Diseases [Amsterdam, Netherlands] (Academic Medical Center), University of Amsterdam [Amsterdam] (UvA)-Center for Tropical and Travel Medicine [Amsterdam, Netherlands], Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires (PPSM), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS), Centre for Tropical Diseases [Montréal] (TDC), McGill University, Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), Department of Tropical Medicine and Infectious Diseases, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany, Bernhard-Nocht-Institute for Tropical Medicine, Tropical Disease Unit [Toronto, Canada], University of Toronto, Hôpital d'Instruction des Armées Laveran, Service de Santé des Armées, Geneva University Hospitals - HUG [Switzerland], Hôpital d'Instruction des Armées Begin, Department of Epidemiology and Preventive Medicine, Monash University, Victoria, Australia, Monash University [Clayton], Addenbrooke's Hospital, Cambridge University NHS Trust, Service de médecine interne et maladies infectieuses, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Université Paris Descartes - Paris 5 (UPD5), University of Cape Town, National Institute for Communicable Diseases (NICD), CIWEC Clinic Travel Medicine Center, Katmandu, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), École normale supérieure - Cachan (ENS Cachan)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), McGill University = Université McGill [Montréal, Canada], Bernhard Nocht Institute for Tropical Medicine - Bernhard-Nocht-Institut für Tropenmedizin [Hamburg, Germany] (BNITM), National Institute for Communicable Diseases [Johannesburg] (NICD), Infectious diseases, AII - Infectious diseases, APH - Aging & Later Life, APH - Global Health, and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA)

Subjects
Leishmaniasis, Mucocutaneous, Male, Immigration, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Epidemiology, Species identification, 030212 general & internal medicine, Political instability, Child, ComputingMilieux_MISCELLANEOUS, media_common, Aged, 80 and over, Transients and Migrants, Cutaneous leishmaniasis, Geosentinel, Mucosal leishmaniasis, Skin lesions after travel, Tegumentary leishmaniasis, Vector-borne disease, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, General Medicine, Middle Aged, 3. Good health, Child, Preschool, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Female, Original Article, Travel-Related Illness, Adult, Costa Rica, Bolivia, Canada, medicine.medical_specialty, Adolescent, media_common.quotation_subject, 030231 tropical medicine, Young Adult, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, medicine, Leishmania (Viannia) braziliensis, Humans, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Aged, Syria, business.industry, Afghanistan, Infant, Leishmaniasis, Mucocutaneous leishmaniasis, medicine.disease, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, business, Demography
Abstract

Background Cutaneous leishmaniasis (CL) may be emerging among international travellers and migrants. Limited data exist on mucocutaneous leishmaniasis (MCL) in travellers. We describe the epidemiology of travel-associated CL and MCL among international travellers and immigrants over a 20-year period through descriptive analysis of GeoSentinel data. Methods Demographic and travel-related data on returned international travellers diagnosed with CL or MCL at a GeoSentinel Surveillance Network site between 1 September 1997 and 31 August 2017 were analysed. Results A total of 955 returned travellers or migrants were diagnosed with travel-acquired CL (n = 916) or MCL during the study period, of whom 10% (n = 97) were migrants. For the 858 non-migrant travellers, common source countries were Bolivia (n = 156, 18.2%) and Costa Rica (n = 97, 11.3%), while for migrants, they were Syria (n = 34, 35%) and Afghanistan (n = 22, 22.7%). A total of 99 travellers (10%) acquired their disease on trips of ≤ 2 weeks. Of 274 cases for which species identification was available, Leishmania Viannia braziliensis was the most well-represented strain (n = 117, 42.7%), followed by L. major (n = 40, 14.6%) and L. V. panamensis (n = 38, 13.9%). Forty cases of MCL occurred, most commonly in tourists (n = 29, 72.5%) and from Bolivia (n = 18, 45%). A total of 10% of MCL cases were acquired in the Old World. Conclusions Among GeoSentinel reporting sites, CL is predominantly a disease of tourists travelling mostly to countries in Central and South America such as Bolivia where risk of acquiring L. V. braziliensis and subsequent MCL is high. The finding that some travellers acquired leishmaniasis on trips of short duration challenges the common notion that CL is a disease of prolonged travel. Migrants from areas of conflict and political instability, such as Afghanistan and Syria, were well represented, suggesting that as mass migration of refugees continues, CL will be increasingly encountered in intake countries.

Published
2019

20. Travel-related infections presenting in Europe: A 20-year analysis of EuroTravNet surveillance data

Author

Grobusch, Martin P., primary, Weld, Leisa, additional, Goorhuis, Abraham, additional, Hamer, Davidson H., additional, Schunk, Mirjam, additional, Jordan, Sabine, additional, Mockenhaupt, Frank P., additional, Chappuis, François, additional, Asgeirsson, Hilmir, additional, Caumes, Eric, additional, Jensenius, Mogens, additional, van Genderen, Perry J.J., additional, Castelli, Francesco, additional, López-Velez, Rogelio, additional, Field, Vanessa, additional, Bottieau, Emmanuel, additional, Molina, Israel, additional, Rapp, Christophe, additional, Ménendez, Marta Díaz, additional, Gkrania-Klotsas, Effrossyni, additional, Larsen, Carsten S., additional, Malvy, Denis, additional, Lalloo, David, additional, Gobbi, Federico, additional, Florescu, Simin A., additional, Gautret, Philippe, additional, and Schlagenhauf, Patricia, additional

Published
2021
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21. Leishmaniasis i Norge

Author

Müller, Karl Erik, primary, Blomberg, Bjørn, primary, Tellevik, Marit Gjerde, primary, Jensenius, Mogens, primary, Fladeby, Cathrine, primary, Lier, Tore, primary, Sand, Geir, primary, Hannula, Raisa, primary, Langeland, Nina, primary, and Mørch, Kristine, primary

Published
2021
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22. Rickettsioses and the international traveler

Author

Jensenius, Mogens, Fournier, Pierre-Edouard, and Raoult, Didier

Subjects
Communicable diseases -- Risk factors, Communicable diseases -- Causes of, Communicable diseases -- Prevention, Rickettsia -- Risk factors, Rickettsia -- Causes of, Rickettsia -- Prevention, Medical research, Medicine, Experimental, Health, Health care industry
Published
2004

23. African tick bite fever

Author

Jensenius, Mogens, Fournier, Pierre-Edouard, Kelly, Patrick, Myrvang, BjA[cedilla]Rn, and Raoult, Didier

Subjects
Disease transmission
Published
2003

24. African tick bite fever in travelers to rural sub-equatorial Africa. (Major Article)

Author

Jensenius, Mogens, Fournier, Pierre-Edouard, Vene, Sirkka, Hoel, Terje, Hasle, Gunnar, Henriksen, Arne Z., Hellum, Kjell Block, Raoult, Didier, and Myrvang, Bjorn

Subjects
Tick-borne diseases -- Diagnosis, Tick-borne diseases -- Risk factors, Symptomatology, Safaris -- Health aspects, Travel -- Health aspects, Travel -- Africa, Health, Health care industry
Published
2003

25. Rickettsia africae, a tick-borne pathogen in travelers to sub-Saharan Africa

Author

Raoult, Didier, Fournier, Pierre E., FEnollar, Florence, Jensenius, Mogens, Prioe, Tine, Pina, Jean J. de, Caruso, Giuseppe, Jones, Nicola, Laferl, Herman, Rosenblatt, John E., and Marrie, Thomas J.

Subjects
Rickettsial diseases -- Africa
Abstract

Rickettsia africae appears to be the cause of many tick-borne rickettsial diseases in Africa. This organism was not discovered until 1992 and until then, all tick-borne rickettsial diseases in Europe and Africa were thought to be caused by Rickettsia conorii.

Published
2001

26. Epidemiological and Clinical Characteristics of International Travelers with Enteric Fever and Antibiotic Resistance Profiles of Their Isolates: a GeoSentinel Analysis

Author

Hagmann, Stefan H. F., primary, Angelo, Kristina M., additional, Huits, Ralph, additional, Plewes, Katherine, additional, Eperon, Gilles, additional, Grobusch, Martin P., additional, McCarthy, Anne, additional, Libman, Michael, additional, Caumes, Eric, additional, Leung, Daniel T., additional, Asgeirsson, Hilmir, additional, Jensenius, Mogens, additional, Schwartz, Eli, additional, Sánchez-Montalvá, Adrian, additional, Kelly, Paul, additional, Pandey, Prativa, additional, Leder, Karin, additional, Bourque, Daniel L., additional, Yoshimura, Yukihiro, additional, Mockenhaupt, Frank P., additional, van Genderen, Perry J. J., additional, Odolini, Silvia, additional, Schlagenhauf, Patricia, additional, Connor, Bradley A., additional, and Hamer, Davidson H., additional

Published
2020
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29. The rise in travel-associated measles infections-GeoSentinel, 2015-2019

Author

Angelo, Kristina, Libman, Michael, Gautret, Philippe, Barnett, Elizabeth, Grobusch, Martin, Hagmann, Stefan, Gobbi, Federico, Schwartz, Eli, van Genderen, Perry, Asgeirsson, Hilmer, Hamer, Davidson, Larsen, Carsten Schade, Wejse, Christian, Goorhuis, Bram, Piyaphanee, Watcharapong, Silachamroon, Udomsak, Kuhn, Susan, Perez, Cecilia Perret, Weitzel, Thomas, Mendelson, Marc, Parker, Salim, Piper-Jenks, Nancy, Kerr, Christine, Lachish, Tamar, Pandey, Prativa, Murphy, Holly, Menéndez, Marta, Esteban, Elena, Leder, Karin, Torresi, Joe, Mavunda, Kunjana, Rothe, Camilla, von Sonnenburg, Frank, Javelle, Emilie, Ward, Brian, Jensenius, Mogens, Caumes, Eric, Lim, Poh Lian, Glans, Hedvig, Yoshimura, Yukihiro, Tachikawa, Natsuo, Division of Global Migration and Quarantine [Atlanta, GA, USA], Centers for Disease Control and Prevention (CDC), Centre for Tropical Diseases [Montréal] (TDC), McGill University = Université McGill [Montréal, Canada], Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Department of Infectious Diseases [Amsterdam, Netherlands] (Academic Medical Center), University of Amsterdam [Amsterdam] (UvA)-Center for Tropical and Travel Medicine [Amsterdam, Netherlands], Cohen Children’s Medical Center, Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires (PPSM), École normale supérieure - Cachan (ENS Cachan)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of Cape Town, Département de radiothérapie, CRLCC Val d'Aurelle - Paul Lamarque, CIWEC Clinic Travel Medicine Center, Katmandu, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Laboratoire d'Economie de Dauphine (LEDa), Institut de Recherche pour le Développement (IRD)-Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Department of Epidemiology and Preventive Medicine, Monash University, Victoria, Australia, Monash University [Clayton], Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Département des Maladies infectieuses [Marseille], Hôpital d'instruction des armées Laveran [Marseille], Service de Maladies Infectieuses et Tropicales [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), McGill University, Institut Hospitalier Universitaire Méditerranée Infection (IHU AMU), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Dauphine-PSL, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Service des maladies infectieuses [CHU Pitié-Salêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière], Institut de Recherche pour le Développement (IRD)-Université Paris Dauphine-PSL-Centre National de la Recherche Scientifique (CNRS), Infectious diseases, AII - Infectious diseases, APH - Aging & Later Life, APH - Global Health, and Medical Microbiology & Infectious Diseases

Subjects
Adult, Male, Vaccination Coverage, Adolescent, Measles Vaccine, 030231 tropical medicine, MEDLINE, Global Health, Measles, Article, Young Adult, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Environmental health, Global health, Humans, Medicine, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, 030212 general & internal medicine, Young adult, Child, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, business.industry, Infant, General Medicine, Middle Aged, medicine.disease, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, 3. Good health, Hospitalization, Child, Preschool, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Female, Measles vaccine, Travel-Related Illness, business
Abstract

The global threat of measles in recent years affects international travelers, and is acquired in both endemic and outbreak settings. The number of measles cases reported to GeoSentinel has risen each year since 2015 and demonstrates a high median age, short travel duration, and low measles vaccination coverage.

Published
2019

31. Fascioliasis imported to Norway

Author

Jensenius, MOGENS, Flægstad, TROND, Stenstad, TORE, Gjølberg, TOR, Vlatkovic, LJILJANA, Schjøth-iversen, LINE, Berild, DAG, and Myrvang, BJØRN

Published
2005

33. Prospective European-wide multicentre study on a blood based real-time PCR for the diagnosis of acute schistosomiasis

Author

Wichmann Dominic, Poppert Sven, Von Thien Heidrun, Clerinx Joannes, Dieckmann Sebastian, Jensenius Mogens, Parola Philippe, Richter Joachim, Schunk Mirjam, Stich August, Zanger Philipp, Burchard Gerd D, and Tannich Egbert

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Acute schistosomiasis constitutes a rare but serious condition in individuals experiencing their first prepatent Schistosoma infection. To circumvent costly and time-consuming diagnostics, an early and rapid diagnosis is required. So far, classic diagnostic tools such as parasite microscopy or serology lack considerable sensitivity at this early stage of Schistosoma infection. To validate the use of a blood based real-time polymerase chain reaction (PCR) test for the detection of Schistosoma DNA in patients with acute schistosomiasis who acquired their infection in various endemic regions we conducted a European-wide prospective study in 11 centres specialized in travel medicine and tropical medicine. Methods Patients with a history of recent travelling to schistosomiasis endemic regions and freshwater contacts, an episode of fever (body temperature ≥38.5°C) and an absolute or relative eosinophil count of ≥700/μl or 10%, were eligible for participation. PCR testing with DNA extracted from serum was compared with results from serology and microscopy. Results Of the 38 patients with acute schistosomiasis included into the study, PCR detected Schistosoma DNA in 35 patients at initial presentation (sensitivity 92%). In contrast, sensitivity of serology (enzyme immunoassay and/or immunofluorescence assay) or parasite microscopy was only 70% and 24%, respectively. Conclusion For the early diagnosis of acute schistosomiasis, real-time PCR for the detection of schistosoma DNA in serum is more sensitive than classic diagnostic tools such as serology or microscopy, irrespective of the region of infection. Generalization of the results to all Schistosoma species may be difficult as in the study presented here only eggs of S. mansoni were detected by microscopy. A minimum amount of two millilitre of serum is required for sufficient diagnostic accuracy.

Published
2013
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35. Severe malaria and artesunate treatment, Norway

Author

Morch, Kristine, Strand, Oystein, Dunlop, Oona, Berg, Ase, Langeland, Nina, Leiva, Rafael A.M., Longva, Jorn-Age, Sjursen, Hakon, Skrede, Steinar, Sundal, Jon, and Jensenius, Mogens

Subjects
Malaria -- Causes of, Malaria -- Drug therapy, Plasmodium falciparum -- Health aspects, Antimalarials -- Dosage and administration, Antimalarials -- Complications and side effects
Abstract

To the Editor: Approximately 8,000 cases of imported falciparum malaria are reported in Europe each year (1). In a study from Belgium of 1,743 persons with fever acquired in the [...]

Published
2008

36. MOESM2 of Area of exposure and treatment challenges of malaria in Eritrean migrants: a GeoSentinel analysis

Author

Schlagenhauf, Patricia, Grobusch, Martin, Hamer, Davidson, Asgeirsson, Hilmir, Jensenius, Mogens, Eperon, Gilles, Rothe, Camilla, Isenring, Egon, Fehr, Jan, Schwartz, Eli, Bottieau, Emmanuel, Barnett, Elizabeth, McCarthy, Anne, Kelly, Paul, Larsen, Carsten Schade, Genderen, Perry, Stauffer, William, Libman, Michael, and Gautret, Philippe

Abstract

Additional file 2. Availability of primaquine and G6PDH deficiency testing at GeoSentinel sites.

Published
2018
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37. Travel and migration associated infectious diseases morbidity in Europe, 2008

Author

Lopez-Velez Rogelio, Weld Leisa, Gkrania-Klotsas Effrossyni, Castelli Francesco, Jensenius Mogens, Caumes Eric, Burchard Gerd-Dieter, Schlagenhauf Patricia, Gautret Philippe, Field Vanessa, de Vries Peter, von Sonnenburg Frank, Loutan Louis, and Parola Philippe

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Europeans represent the majority of international travellers and clinicians encountering returned patients have an essential role in recognizing, and communicating travel-associated public health risks. Methods To investigate the morbidity of travel associated infectious diseases in European travellers, we analysed diagnoses with demographic, clinical and travel-related predictors of disease, in 6957 ill returned travellers who presented in 2008 to EuroTravNet centres with a presumed travel associated condition. Results Gastro-intestinal (GI) diseases accounted for 33% of illnesses, followed by febrile systemic illnesses (20%), dermatological conditions (12%) and respiratory illnesses (8%). There were 3 deaths recorded; a sepsis caused by Escherichia coli pyelonephritis, a dengue shock syndrome and a Plasmodium falciparum malaria. GI conditions included bacterial acute diarrhea (6.9%), as well as giardiasis and amebasis (2.3%). Among febrile systemic illnesses with identified pathogens, malaria (5.4%) accounted for most cases followed by dengue (1.9%) and others including chikungunya, rickettsial diseases, leptospirosis, brucellosis, Epstein Barr virus infections, tick-borne encephalitis (TBE) and viral hepatitis. Dermatological conditions were dominated by bacterial infections, arthropod bites, cutaneous larva migrans and animal bites requiring rabies post-exposure prophylaxis and also leishmaniasis, myasis, tungiasis and one case of leprosy. Respiratory illness included 112 cases of tuberculosis including cases of multi-drug resistant or extensively drug resistant tuberculosis, 104 cases of influenza like illness, and 5 cases of Legionnaires disease. Sexually transmitted infections (STI) accounted for 0.6% of total diagnoses and included HIV infection and syphilis. A total of 165 cases of potentially vaccine preventable diseases were reported. Purpose of travel and destination specific risk factors was identified for several diagnoses such as Chagas disease in immigrant travellers from South America and P. falciparum malaria in immigrants from sub-Saharan Africa. Travel within Europe was also associated with health risks with distinctive profiles for Eastern and Western Europe. Conclusions In 2008, a broad spectrum of travel associated diseases were diagnosed at EuroTravNet core sites. Diagnoses varied according to regions visited by ill travellers. The spectrum of travel associated morbidity also shows that there is a need to dispel the misconception that travel, close to home, in Europe, is without significant health risk.

Published
2010
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39. Rabies post-exposure prophylaxis started during or after travel: A GeoSentinel analysis

Author

Gautret, Philippe, Angelo, Kristina M, Asgeirsson, Hilmir, Lalloo, David G, Shaw, Marc, Schwartz, Eli, Libman, Michael, Kain, Kevin C, Piyaphanee, Watcharapong, Murphy, Holly, Leder, Karin, Vincelette, Jean, Jensenius, Mogens, Waggoner, Jesse, Leung, Daniel, Borwein, Sarah, Blumberg, Lucille, Schlagenhauf, Patricia, Barnett, Elizabeth D, Hamer, Davidson H, Gautret, Philippe, Angelo, Kristina M, Asgeirsson, Hilmir, Lalloo, David G, Shaw, Marc, Schwartz, Eli, Libman, Michael, Kain, Kevin C, Piyaphanee, Watcharapong, Murphy, Holly, Leder, Karin, Vincelette, Jean, Jensenius, Mogens, Waggoner, Jesse, Leung, Daniel, Borwein, Sarah, Blumberg, Lucille, Schlagenhauf, Patricia, Barnett, Elizabeth D, and Hamer, Davidson H

Abstract

BACKGROUND Recent studies demonstrate that rabies post-exposure prophylaxis (RPEP) in international travelers is suboptimal, with only 5-20% of travelers receiving rabies immune globulin (RIG) in the country of exposure when indicated. We hypothesized that travelers may not be receiving RIG appropriately, and practices may vary between countries. We aim to describe the characteristics of travelers who received RIG and/or RPEP during travel. METHODOLOGY/PRINCIPAL FINDINGS We conducted a multi-center review of international travelers exposed to potentially rabid animals, collecting information on RPEP administration. Travelers who started RPEP before (Group A) and at (Group B) presentation to a GeoSentinel clinic during September 2014-July 2017 were included. We included 920 travelers who started RPEP. About two-thirds of Group A travelers with an indication for rabies immunoglobulin (RIG) did not receive it. Travelers exposed in Indonesia were less likely to receive RIG in the country of exposure (relative risk: 0.30; 95% confidence interval: 0.12-0.73; P = 0.01). Travelers exposed in Thailand [Relative risk (RR) 1.38, 95% Confidence Interval (95% CI): 1.0-1.8; P = 0.02], Sri Lanka (RR 3.99, 95% CI: 3.99-11.9; P = 0.013), and the Philippines (RR 19.95, 95% CI: 2.5-157.2; P = 0.01), were more likely to receive RIG in the country of exposure. CONCLUSIONS/SIGNIFICANCE This analysis highlights gaps in early delivery of RIG to travelers and identifies specific countries where travelers may be more or less likely to receive RIG. More detailed country-level information helps inform risk education of international travelers regarding appropriate rabies prevention.

Published
2018

40. Area of exposure and treatment challenges of malaria in Eritrean migrants: a GeoSentinel analysis

Author

Schlagenhauf, Patricia; https://orcid.org/0000-0002-1075-7010, Grobusch, Martin P, Hamer, Davidson H, Asgeirsson, Hilmir, Jensenius, Mogens, Eperon, Gilles, Rothe, Camilla, Isenring, Egon, Fehr, Jan, Schwartz, Eli, Bottieau, Emmanuel, Barnett, Elizabeth D, McCarthy, Anne, Kelly, Paul, Schade Larsen, Carsten, van Genderen, Perry, Stauffer, William, Libman, Michael, Gautret, Philippe, Schlagenhauf, Patricia; https://orcid.org/0000-0002-1075-7010, Grobusch, Martin P, Hamer, Davidson H, Asgeirsson, Hilmir, Jensenius, Mogens, Eperon, Gilles, Rothe, Camilla, Isenring, Egon, Fehr, Jan, Schwartz, Eli, Bottieau, Emmanuel, Barnett, Elizabeth D, McCarthy, Anne, Kelly, Paul, Schade Larsen, Carsten, van Genderen, Perry, Stauffer, William, Libman, Michael, and Gautret, Philippe

Abstract

BACKGROUND Recent reports highlight malaria as a frequent diagnosis in migrants who originate from Eritrea. A descriptive analysis of GeoSentinel cases of malaria in Eritrean migrants was done together with a literature review to elucidate key attributes of malaria in this group with a focus on possible areas of acquisition of malaria and treatment challenges. RESULTS A total of 146 cases were identified from the GeoSentinel database from 1999 through September 2017, with a marked increase in 2014 and 2015. All patients originated from Eritrea and the main reporting GeoSentinel sites were in Norway, Switzerland, Sweden, Israel and Germany. The majority of patients (young adult males) were diagnosed with malaria following arrival in the host country. All patients had a possible exposure in Eritrea, but may have been exposed in documented transit countries including Ethiopia, Sudan and possibly Libya in detention centres. Most infections were due to Plasmodium vivax (84.2%), followed by Plasmodium falciparum (8.2%). Two patients were pregnant, and both had P. vivax malaria. Some 31% of the migrants reported having had malaria while in transit. The median time to onset of malaria symptoms post arrival in the host country was 39 days. Some 66% of patients were hospitalized and nine patients had severe malaria (according to WHO criteria), including five due to P. vivax. CONCLUSIONS The 146 cases of mainly late onset, sometimes severe, P. vivax malaria in Eritrean migrants described in this multi-site, global analysis reflect the findings of single-centre analyses identified in the literature search. Host countries receiving asylum-seekers from Eritrea need to be prepared for large surges in vivax and, to a lesser extent, falciparum malaria, and need to be aware and prepared for glucose-6-phosphate dehydrogenase deficiency testing and primaquine treatment, which is difficult to procure and mainly unlicensed in Europe. There is an urgent need to explore the molecular epide

Published
2018

41. Malaria after international travel: a GeoSentinel analysis, 2003-2016

Author

Angelo, Kristina M., Libman, Michael, Caumes, Eric, Hamer, Davidson H., Kain, Kevin C., Leder, Karin, Grobusch, Martin P., Hagmann, Stefan H., Kozarsky, Phyllis, Lalloo, David G., Lim, Poh-Lian, Patimeteeporn, Calvin, Gautret, Philippe, Odolini, Silvia, Chappuis, Franã§ois, Esposito, Douglas H., Javelle, Emilie, Castelli, Francesco, Matteelli, Alberto, Perignon, Alice, Rothe, Camilla, Rapp, Christoph, Ficko, Cecile, Schwartz, Eli, Von Sonnenburg, Frank, Piyaphanee, Watcharapong, Silachamroon, Udomsak, Boggild, Andrea, Van Genderen, Perry, Torresi, Joe, Jensenius, Mogens, Kanagawa, Shuzo, Kato, Yasuyuki, Yansouni, Cedric, Mccarthy, Anne, Kelly, Paul, Goorhuis, Bram, López-Vélez, Rogelio, Norman, Francesco, Mendelson, Marc, Vincent, Peter, Gkrania-Klotsas, Effrossyni, Warne, Ben, Malvy, Denis, Duvignaud, Alexandre, Bottieau, Emanuel, Clerinx, Joannes, Coyle, Christina, Àsgeirsson, Hilmer, Glans, Hedvig, Schlagenhauf, Patricia, Weber, Rainer, Mockenhaupt, Frank, Harms-Zwingenberger, Gundel, Beeching, Nicholas, Hajek, Jan, Ghesquiere, Wayne, Henry, Wu, Barnett, Elizabeth, Hockberg, Natasha, Yoshimura, Yukiriro, Tachikawa, Natsuo, Cahill, John, Mckinley, George, Stauffer, William, Walker, Pat, Kuhn, Susan, Chen, Lin, Leung, Daniel, Benson, Scott, Larsen, Carsten Schade, Wejse, Christian, Field, Vanessa, Licitra, Carmelo, Klochko, Alena, Hynes, Noreen, Perez, Cecilia Perret, Connor, Bradley, Murphy, Holly, Pandey, Prativa, Vincelette, Jean, Barkati, Sapha, Florescu, Simin Aysel, Popescu, Corneliu Petru, Blumberg, Lucille, De Frey, Albie, Anderson, Susan, Shaw, Marc, Hern, Annemarie, Molina, Israel, Yates, Johnnie, Siu, Hugo, Valdez, Luis Manuel, Haulman, Jean, Roesel, David, Phu, Phi Truong Hoang, Borwein, Sarah, Division of Global Migration and Quarantine [Atlanta, GA, USA], Centers for Disease Control and Prevention (CDC), Centre for Tropical Diseases [Montréal] (TDC), McGill University = Université McGill [Montréal, Canada], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Department of Global Health and Center for Global Health and Development [Boston, MA, USA], Boston University [Boston] (BU), Tropical Disease Unit [Toronto, Canada], University of Toronto, Victorian Infectious Diseases Service [Victoria, Australia], The Royal Melbourne Hospital, School of Public Health and Preventive Medicine [Monash University-Melbourne], Monash University [Melbourne], Department of Infectious Diseases [Amsterdam, Netherlands] (Academic Medical Center), University of Amsterdam [Amsterdam] (UvA)-Center for Tropical and Travel Medicine [Amsterdam, Netherlands], Cohen Children’s Medical Center, Department of Medicine [Atlanta, GA, USA], Emory University [Atlanta, GA], Liverpool School of Tropical Medicine (LSTM), Institute of Infectious Diseases and Epidemiology [Singapore, Singapore], Tan Tock Seng Hospital, Lee Kong Chian School of Medicine, Nanyang Technological University [Singapour], Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes (URMITE), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Department of Infectious and Tropical Diseases [Brescia, Italy], University of Brescia and Spedali Civili General Hospital [Brescia, Italy], Geneva University Hospitals - HUG [Switzerland], Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Tan Tock Seng Hospital [Singapore, Singapore], Nanyang Technological University (NTU), INSB-INSB-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), COMBE, Isabelle, Service de Maladies Infectieuses et Tropicales [CHU Pitié-Salpêtrière], AII - Infectious diseases, APH - Global Health, Infectious diseases, APH - Aging & Later Life, AII - Amsterdam institute for Infection and Immunity, Lee Kong Chian School of Medicine (LKCMedicine), Hamer, Davidson H [0000-0002-4700-1495], Kain, Kevin C [0000-0001-6068-1272], Lalloo, David G [0000-0001-7680-2200], Gautret, Philippe [0000-0002-1664-958X], and Apollo - University of Cambridge Repository

Subjects
Plasmodium, Plasmodium vivax, 0302 clinical medicine, GeoSentinel, International travel, Malaria, Plasmodium spp, Parasitology, Infectious Diseases, Interquartile range, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Medicine, Science::Medicine [DRNTU], 030212 general & internal medicine, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Travel, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, biology, wa_108, 3. Good health, Chemoprophylaxis, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Risk, medicine.medical_specialty, Visiting friends and relatives, lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, 030231 tropical medicine, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Environmental health, parasitic diseases, Journal Article, Humans, lcsh:RC109-216, business.industry, Public health, Research, Plasmodium falciparum, biology.organism_classification, medicine.disease, wc_750, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, qx_135, Immunology, Tropical medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, human activities
Abstract

Background\ud \ud More than 30,000 malaria cases are reported annually among international travellers. Despite improvements in malaria control, malaria continues to threaten travellers due to inaccurate perception of risk and sub-optimal pre-travel preparation.\ud \ud Methods\ud \ud Records with a confirmed malaria diagnosis after travel from January 2003 to July 2016 were obtained from GeoSentinel, a global surveillance network of travel and tropical medicine providers that monitors travel-related morbidity. Records were excluded if exposure country was missing or unascertainable or if there was a concomitant acute diagnosis unrelated to malaria. Records were analyzed to describe the demographic and clinical characteristics of international travellers with malaria.\ud \ud Results\ud \ud There were 5689 travellers included; 325 were children

Published
2017

42. Acute and potentially life-threatening tropical diseases in western travelers - a geosentinel multicenter study, 1996-2011

Author

Jensenius, Mogens, Han, Pauline V, Schlagenhauf, Patricia, Schwartz, Eli, Parola, Philippe, Castelli, Francesco, von Sonnenburg, Frank, Loutan, Louis, Leder, Karin, Freedman, David O, University of Zurich, and Jensenius, Mogens

Subjects
2405 Parasitology, 2406 Virology, 610 Medicine & health, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), 2725 Infectious Diseases
Published
2013

43. Profile of illness in Syrian refugees: A GeoSentinel analysis, 2013 to 2015

Author

Mockenhaupt, Frank P, Barbre, Kira A, Jensenius, Mogens, Larsen, Carsten S, Barnett, Elizabeth D, Stauffer, William, Rothe, Camilla, Asgeirsson, Hilmir, Hamer, Davidson H, Esposito, Douglas H, Gautret, Philippe, Schlagenhauf, Patricia, Mockenhaupt, Frank P, Barbre, Kira A, Jensenius, Mogens, Larsen, Carsten S, Barnett, Elizabeth D, Stauffer, William, Rothe, Camilla, Asgeirsson, Hilmir, Hamer, Davidson H, Esposito, Douglas H, Gautret, Philippe, and Schlagenhauf, Patricia

Abstract

Screening of 488 Syrian unaccompanied minor refugees (< 18 years-old) in Berlin showed low prevalence of intestinal parasites (Giardia, 7%), positive schistosomiasis serology (1.4%) and absence of hepatitis B. Among 44 ill adult Syrian refugees examined at GeoSentinel clinics worldwide, cutaneous leishmaniasis affected one in three patients; other noteworthy infections were active tuberculosis (11%) and chronic hepatitis B or C (9%). These data can contribute to evidence-based guidelines for infectious disease screening of Syrian refugees.

Published
2016

44. Arboviral and other illnesses in travellers returning from Brazil, June 2013 to May 2016: implications for the 2016 Olympic and Paralympic Games

Author

Gautret, Philippe, Mockenhaupt, Frank, Grobusch, Martin P, Rothe, Camilla, von Sonnenburg, Frank, van Genderen, Perry J, Chappuis, Francois, Asgeirsson, Hilmir, Caumes, Eric, Bottieau, Emmanuel, Malvy, Denis, Lopez-Vélez, Rogelio, Jensenius, Mogens, Larsen, Carsten Schade, Castelli, Francesco, Rapp, Christophe, Field, Vanessa, Molina, Israel, Gkrania-Klotsas, Effrossyni, Florescu, Simin, Lalloo, David, Schlagenhauf, Patricia, Gautret, Philippe, Mockenhaupt, Frank, Grobusch, Martin P, Rothe, Camilla, von Sonnenburg, Frank, van Genderen, Perry J, Chappuis, Francois, Asgeirsson, Hilmir, Caumes, Eric, Bottieau, Emmanuel, Malvy, Denis, Lopez-Vélez, Rogelio, Jensenius, Mogens, Larsen, Carsten Schade, Castelli, Francesco, Rapp, Christophe, Field, Vanessa, Molina, Israel, Gkrania-Klotsas, Effrossyni, Florescu, Simin, Lalloo, David, and Schlagenhauf, Patricia

Abstract

We evaluated EuroTravNet (a GeoSentinel subnetwork) data from June 2013 to May 2016 on 508 ill travellers returning from Brazil, to inform a risk analysis for Europeans visiting the 2016 Olympic and Paralympic Games in Brazil. Few dengue fever cases (n = 3) and no cases of chikungunya were documented during the 2013-15 Brazilian winter months, August and September, the period when the Games will be held. The main diagnoses were dermatological (37%), gastrointestinal (30%), febrile systemic illness (29%) and respiratory (11%).

Published
2016

45. Arboviral and other illnesses in travellers returning from Brazil, June 2013 to May 2016: implications for the 2016 Olympic and Paralympic Games

Author

Gautret, Philippe, primary, Mockenhaupt, Frank, additional, Grobusch, Martin P, additional, Rothe, Camilla, additional, von Sonnenburg, Frank, additional, van Genderen, Perry J, additional, Chappuis, Francois, additional, Asgeirsson, Hilmir, additional, Caumes, Eric, additional, Bottieau, Emmanuel, additional, Malvy, Denis, additional, Lopez-Vélez, Rogelio, additional, Jensenius, Mogens, additional, Larsen, Carsten Schade, additional, Castelli, Francesco, additional, Rapp, Christophe, additional, Field, Vanessa, additional, Molina, Israel, additional, Gkrania-Klotsas, Effrossyni, additional, Florescu, Simin, additional, Lalloo, David, additional, and Schlagenhauf, Patricia, additional

Published
2016
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46. Profile of illness in Syrian refugees: A GeoSentinel analysis, 2013 to 2015

Author

Mockenhaupt, Frank P., primary, Barbre, Kira A., additional, Jensenius, Mogens, additional, Larsen, Carsten S., additional, Barnett, Elizabeth D., additional, Stauffer, William, additional, Rothe, Camilla, additional, Asgeirsson, Hilmir, additional, Hamer, Davidson H., additional, Esposito, Douglas H., additional, Gautret, Philippe, additional, and Schlagenhauf, Patricia, additional

Published
2016
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47. Travel and migration associated infectious diseases morbidity in Europe, 2008

Author

Field, Vanessa, Gautret, Philippe, Schlagenhauf, Patricia, Burchard, Gerd-Dieter, Caumes, Eric, Jensenius, Mogens, Castelli, Francesco, Gkrania-Klotsas, Effrossyni, Weld, Leisa, Lopez-Velez, Rogelio, de Vries, Peter, von Sonnenburg, Frank, Loutan, Louis, Parola, Philippe, EuroTravNet network, Gkrania-Klotsas, Effrossyni [0000-0002-0930-8330], and Apollo - University of Cambridge Repository

Subjects
Adult, Aged, 80 and over, Male, Travel, Adolescent, Fever, Gastrointestinal Diseases, Respiratory Tract Diseases, Infant, Newborn, Infant, Middle Aged, Communicable Diseases, Skin Diseases, Europe, Young Adult, Child, Preschool, Humans, Child, Travel Medicine, Aged
Abstract

BACKGROUND: Europeans represent the majority of international travellers and clinicians encountering returned patients have an essential role in recognizing, and communicating travel-associated public health risks. METHODS: To investigate the morbidity of travel associated infectious diseases in European travellers, we analysed diagnoses with demographic, clinical and travel-related predictors of disease, in 6957 ill returned travellers who presented in 2008 to EuroTravNet centres with a presumed travel associated condition. RESULTS: Gastro-intestinal (GI) diseases accounted for 33% of illnesses, followed by febrile systemic illnesses (20%), dermatological conditions (12%) and respiratory illnesses (8%). There were 3 deaths recorded; a sepsis caused by Escherichia coli pyelonephritis, a dengue shock syndrome and a Plasmodium falciparum malaria.GI conditions included bacterial acute diarrhea (6.9%), as well as giardiasis and amebasis (2.3%). Among febrile systemic illnesses with identified pathogens, malaria (5.4%) accounted for most cases followed by dengue (1.9%) and others including chikungunya, rickettsial diseases, leptospirosis, brucellosis, Epstein Barr virus infections, tick-borne encephalitis (TBE) and viral hepatitis. Dermatological conditions were dominated by bacterial infections, arthropod bites, cutaneous larva migrans and animal bites requiring rabies post-exposure prophylaxis and also leishmaniasis, myasis, tungiasis and one case of leprosy. Respiratory illness included 112 cases of tuberculosis including cases of multi-drug resistant or extensively drug resistant tuberculosis, 104 cases of influenza like illness, and 5 cases of Legionnaires disease. Sexually transmitted infections (STI) accounted for 0.6% of total diagnoses and included HIV infection and syphilis. A total of 165 cases of potentially vaccine preventable diseases were reported. Purpose of travel and destination specific risk factors was identified for several diagnoses such as Chagas disease in immigrant travellers from South America and P. falciparum malaria in immigrants from sub-Saharan Africa. Travel within Europe was also associated with health risks with distinctive profiles for Eastern and Western Europe. CONCLUSIONS: In 2008, a broad spectrum of travel associated diseases were diagnosed at EuroTravNet core sites. Diagnoses varied according to regions visited by ill travellers. The spectrum of travel associated morbidity also shows that there is a need to dispel the misconception that travel, close to home, in Europe, is without significant health risk.

Published
2010

48. Travel-associated infection presenting in Europe (2008–12): an analysis of EuroTravNet longitudinal, surveillance data, and evaluation of the effect of the pre-travel consultation

Author

Schlagenhauf, Patricia, primary, Weld, Leisa, additional, Goorhuis, Abraham, additional, Gautret, Philippe, additional, Weber, Rainer, additional, von Sonnenburg, Frank, additional, Lopez-Vélez, Rogelio, additional, Jensenius, Mogens, additional, Cramer, Jakob P, additional, Field, Vanessa K, additional, Odolini, Silvia, additional, Gkrania-Klotsas, Effrossyni, additional, Chappuis, Francois, additional, Malvy, Denis, additional, van Genderen, Perry J J, additional, Mockenhaupt, Frank, additional, Jauréguiberry, Stéphane, additional, Smith, Catherine, additional, Beeching, Nicholas J, additional, Ursing, Johan, additional, Rapp, Christophe, additional, Parola, Philippe, additional, and Grobusch, Martin P, additional

Published
2015
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49. Illness in travelers returned from Brazil: the GeoSentinel experience and implications for the 2014 FIFA World Cup and the 2016 Summer Olympics

Author

Wilson, Mary E, Chen, Lin H, Han, Pauline V, Keystone, Jay S, Cramer, Jakob P, Segurado, Aluisio, Hale, DeVon, Jensenius, Mogens, Schwartz, Eli, von Sonnenburg, Frank, Leder, Karin, Wilson, Mary E, Chen, Lin H, Han, Pauline V, Keystone, Jay S, Cramer, Jakob P, Segurado, Aluisio, Hale, DeVon, Jensenius, Mogens, Schwartz, Eli, von Sonnenburg, Frank, and Leder, Karin

Abstract

BACKGROUND: Brazil will host the 2014 FIFA World Cup and the 2016 Olympic and Paralympic Games, events that are expected to attract hundreds of thousands of international travelers. Travelers to Brazil will encounter locally endemic infections as well as mass event-specific risks. METHODS: We describe 1586 ill returned travelers who had visited Brazil and were seen at a GeoSentinel Clinic from July 1997 through May 2013. RESULTS: The most common travel-related illnesses were dermatologic conditions (40%), diarrheal syndromes (25%), and febrile systemic illness (19%). The most common specific dermatologic diagnoses were cutaneous larva migrans, myiasis, and tungiasis. Dengue and malaria, predominantly Plasmodium vivax, were the most frequently identified specific causes of fever and the most common reasons for hospitalization after travel. Dengue fever diagnoses displayed marked seasonality, although cases were seen throughout the year. Among the 28 ill returned travelers with human immunodeficiency virus (HIV) infection, 11 had newly diagnosed asymptomatic infection and 9 had acute symptomatic HIV. CONCLUSIONS: Our analysis primarily identified infectious diseases among travelers to Brazil. Knowledge of illness in travelers returning from Brazil can assist clinicians to advise prospective travelers and guide pretravel preparation, including itinerary-tailored advice, vaccines, and chemoprophylaxis; it can also help to focus posttravel evaluation of ill returned travelers. Travelers planning to attend mass events will encounter other risks that are not captured in our surveillance network.

Published
2014

50. Zika beyond the Americas: Travelers as sentinels of Zika virus transmission. A GeoSentinel analysis, 2012 to 2016.

Author

Leder, Karin, Grobusch, Martin P., Gautret, Philippe, Chen, Lin H., Kuhn, Susan, Lim, Poh Lian, Yates, Johnnie, McCarthy, Anne E., Rothe, Camilla, Kato, Yasuyuki, Bottieau, Emmanuel, Huber, Kristina, Schwartz, Eli, Stauffer, William, Malvy, Denis, Shaw, Marc T. M., Rapp, Christophe, Blumberg, Lucille, Jensenius, Mogens, and van Genderen, Perry J. J.

Subjects
EPIDEMIOLOGY, PUBLIC health surveillance, ZIKA virus infections, DESCRIPTIVE statistics, TROPICAL medicine, DIAGNOSIS, VIRAL transmission
Abstract

Background: Zika virus (ZIKV) was first isolated in Africa; decades later, caused large outbreaks in the Pacific, and is considered endemic in Asia. We aim to describe ZIKV disease epidemiology outside the Americas, the importance of travelers as sentinels of disease transmission, and discrepancies in travel advisories from major international health organizations. Methods and findings: This descriptive analysis using GeoSentinel Surveillance Network records involves sixty-four travel and tropical medicine clinics in 29 countries. Ill returned travelers with a confirmed or probable diagnosis of ZIKV disease acquired in Africa, Asia and the Pacific seen between 1 January 2012 and 31 December 2016 are included, and the frequencies of demographic, trip, and diagnostic characteristics described. ZIKV was acquired in Asia (18), the Pacific (10) and Africa (1). For five countries (Indonesia, Philippines, Thailand, Vietnam, Cameroon), GeoSentinel patients were sentinel markers of recent Zika activity. Additionally, the first confirmed ZIKV infection acquired in Kiribati was reported to GeoSentinel (2015), and a probable case was reported from Timor Leste (April 2016), representing the only case known to date. Review of Zika situation updates from major international health authorities for country risk classifications shows heterogeneity in ZIKV country travel advisories. Conclusions: Travelers are integral to the global spread of ZIKV, serving as sentinel markers of disease activity. Although GeoSentinel data are collected by specialized clinics and do not capture all imported cases, we show that surveillance of imported infections by returned travelers augments local surveillance system data regarding ZIKV epidemiology and can assist with risk categorization by international authorities. However, travel advisories are variable due to risk uncertainties. [ABSTRACT FROM AUTHOR]

Published
2017
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