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33 results on '"JANSSEN, Cécile"'

1. Impact of vaccination on the presence and severity of symptoms in hospitalized patients with an infection of the Omicron variant (B.1.1.529) of the SARS-CoV-2 (subvariant BA.1)

Author

Beraud, Guillaume, Bouetard, Laura, Civljak, Rok, Michon, Jocelyn, Tulek, Necla, Lejeune, Sophie, Millot, Romain, Garchet-Beaudron, Aurélie, Lefebvre, Maeva, Velikov, Petar, Festou, Benjamin, Abgrall, Sophie, Lizatovic, Ivan K., Baldolli, Aurélie, Esmer, Huseyin, Blanchi, Sophie, Froidevaux, Gabrielle, Kapincheva, Nikol, Faucher, Jean-François, Duvnjak, Mario, Afşar, Elçin, Švitek, Luka, Yarimoglu, Saliha, Yarimoglu, Rafet, Janssen, Cécile, and Epaulard, Olivier

Published
2023
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3. Immunogenicity and reactogenicity of heterologous and homologous mRNA-1273 and BNT162b2 vaccination: A multicenter non-inferiority randomized trial

Author

Janssen, Cécile, Cachanado, Marine, Ninove, Laetitia, Lachatre, Marie, Michon, Jocelyn, Epaulard, Olivier, Maakaroun-Vermesse, Zoha, Chidiac, Christian, Laviolle, Bruno, Aumaitre, Hugues, Assaf, Ady, Lacombe, Karine, Schmidt-Mutter, Catherine, Botelho-Nevers, Elisabeth, Briere, Magali, Boisson, Thomas, Loubet, Paul, Bienvenu, Boris, Bouchaud, Olivier, Touati, Amel, Pereira, Christine, Rousseau, Alexandra, Berard, Laurence, Montil, Melissa, de Lamballerie, Xavier, Simon, Tabassome, and Launay, Odile

Published
2022
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4. A 4-days-on and 3-days-off maintenance treatment strategy for adults with HIV-1 (ANRS 170 QUATUOR): a randomised, open-label, multicentre, parallel, non-inferiority trial

Author

LAMAURY, Isabelle, BANI-SADR, Firouzé, FORCE, Gilles, CHABROL, Amélie, CABY, Fabienne, PATEY, Olivier, FRESARD, Anne, GAGNEUX-BRUNON, Amandine, CHIROUZE, Catherine, DUVIVIER, Claudine, LOURENCO, Jérémie, TOLSMA, Violaine, JANSSEN, Cécile, LEROLLE, Nathalie, CATALAN, Pilartxo, RAMI, Agathe, DE PONTHAUD, Lucile, PICHANCOURT, Gilles, NASRI, Safa, LANDOWSKI, Stéphanie, BOTTERO, Julie, MFUTILA KAYKAY, Flory, PIALOUX, Gilles, BOUCHAUD, Olivier, ABGRALL, Sophie, GATEY, Caroline, WEISS, Laurence, PAVIE, Juliette, SALMON-CERON, Dominique, ZUCMAN, David, LELIEVRE, Jean-Daniel, PALICH, Romain, SIMON, Anne, MEYOHAS, Marie-Caroline, GRAS, Julien, CABIE, André, PIRCHER, Mathilde, MORLAT, Philippe, HESSAMFAR, Mojgam, NEAU, Didier, CAZENAVE, Charles, GENET, Claire, FAUCHER, Jean-François, MAKHLOUFI, Djamila, BOIBIEUX, André, BREGIGEON-RONOT, Sylvie, LAROCHE, Hélène, SAUTEREAU, Aurélie, REYNES, Jacques, MAKINSON, Alain, RAFFI, François, BOLLENGIER-STRAGIER, Olivier, NAQVI, Alissa, CUA, Eric, ROSENTHAL, Eric, ARVIEUX, Cédrick, BUZELE, Rodolphe, REY, David, BATARD, Marie-Laure, BERNARD, Louis, DELOBEL, Pierre, PIFFAUT, Marie, VERDON, Renaud, PIROTH, Lionel, BLOT, Mathieu, LECLERCQ, Pascale, SIGNORI-SCHMUCK, Anne, HULEUX, Thomas, MEYBECK, Agnès, MAY, Thierry, MIAILHES, Patrick, PERPOINT, Thomas, GREDER-BELAN, Alix, ELHARRAR, Brigitte, KHUONG, Marie-Aude, POUPARD, Marie, BLUM, Laurent, MICHAU, Christophe, PRAZUCK, Thierry, PHILIBERT, Patrick, SLAMA, Laurence, HIKOMBO, Hitoto, DARASTEANU, Iuliana, GIRARD, Pierre-Marie, ALVAREZ, Jean-Claude, MATHEZ, Dominique, DE TRUCHIS, Pierre, LANDMAN, Roland, MEYNARD, Jean-Luc, MORAND-JOUBERT, Laurence, LAMBERT, Sidonie, LE DU, Damien, PERRONNE, Christian, ASSOUMOU, Lambert, COSTAGLIOLA, Dominique, MELCHIOR, Jean-Claude, DURACINSKI, Martin, PETROV-SANCHEZ, Ventzislava, AMAT, Karine, BENALYCHERIF, Aïda, SYLLA, Babacar, GELLEY, Ambre, GIBOWSKI, Séverine, LE MEUT, Guillaume, THIEBAUT, Rodolphe, CLUMECK, Nathan, LECLERCQ, Vincent, CECCHERINI-SILBERSTEIN, Francesca, DECOSTER, Laurent, Landman, Roland, de Truchis, Pierre, Assoumou, Lambert, Lambert, Sidonie, Bellet, Jonathan, Amat, Karine, Lefebvre, Bénédicte, Allavena, Clotilde, Katlama, Christine, Yazdanpanah, Yazdan, Molina, Jean-Michel, Petrov-Sanchez, Ventzislava, Gibowski, Séverine, Alvarez, Jean-Claude, Leibowitch, Jacques, Capeau, Jacqueline, Fellahi, Soraya, Duracinsky, Martin, Morand-Joubert, Laurence, Costagliola, Dominique, and Girard, Pierre-Marie

Published
2022
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5. Discontinuing β-lactam treatment after 3 days for patients with community-acquired pneumonia in non-critical care wards (PTC): a double-blind, randomised, placebo-controlled, non-inferiority trial

Author

ATTAL-BEHAR, Julie, BEAUNE, Sébastien, CHINET, Thierry, CUDENNEC, Tristan, DE LAROCHE, Marine, DE THEZY, Albane, DUMOULIN, Jennifer, DUPONT, Caroline, FERCOT, Elise, GIRAUT, Violaine, GREFFE, Ségolène, GRENET, Julie, GUYOT, Caroline, KAHN, Jean-Emmanuel, LABRUNE, Sylvie, LACHATRE, Marie, MOULIAS, Sophie, NALINE, Charlotte, PEPIN, Marion, ROUVEIX, Elisabeth, SAHUT-D'IZARN, Marine, SEFSSAFI, Abel, TEILLET, Laurent, BRU, Jean-Pierre, GAILLAT, Jacques, GAUTIER, Vincent, JANSSEN, Cécile, PAGANI, Leonardo, VITRAT, Virginie, ABDERRAHMANE, Malika, CAMUSET, Juliette, LEGALL, Catherine, LONGUET-FLANDRES, Pascale, MENN, Anne-Marie, DE LASTOURS, Victoire, LECRONIER, Marie, PREVOST, Gwenolée, BURDET, Charles, DERRADJI, Ouda, ESCAUT, Lelia, HINGLAIS, Etienne, LEBRAS, Philippe, LEFEVRE, Edouard, NOAILLON, Mathilde, RABIER, Pauline, RAPHAEL, Maurice, TEICHER, Elina, VERNY, Christiane, VITTECOQ, Daniel, WYPLOSZ, Benjamin, BEN HAYOUN, Michèle, BRUN-VEZINET, Françoise, CASALINO, Enrique, CHOQUET, Christophe, DOMBRET, Marie-Christine, DUVAL, Xavier, HOUHOU, Nadhira, JOLY, Véronique, LESCURE, Xavier, POGLIAGHI, Manuela, RIOUX, Christophe, YAZDANPANAH, Yazdan, BARROS, Elsa, BEGGA, Belinda, BOUKOBZA, Sébastien, BOUREDJI, Houria, CHOUAHI, Imad, DELACROIX, Isabelle, FROISSART, Antoine, GARRAIT, Valérie, NGWEM, Elsa, PHLIPPOTEAU, Catherine, SALEHABADI, Sepehr, TOPER, Cécile, VINAS, Florent, AMSILLI, Marie, EPAULARD, Olivier, PAVESE, Patricia, PIERRE, Isabelle, STAHL, Jean-Paul, AULAGNIER, Jérôme, CELERIER, Julie, COJOCARIU, Roxana, MATHIEU, Emmanuel, RACHLINE, Charlotte, SCHOINDRE, Yoland, SENE, Thomas, THIERRY, Christelle, APARICIO, Caroline, DELCEY, Véronique, LOPES, Amanda, MORGAND, Marjolaine, SELLIER, Pierre, SIMONEAU, Guy, CHAKVETADZE, Catherine, DIAMANTIS, Sylvain, GAUTHIER, Arnaud, JIDAR, Kaoutar, JOURDAIN, Béatrice, BOITIAUX, Jean-Francois, DESCHAMPS, Patrick, DEVAUD, Edouard, PHILIPPE, Bruno, CALIN, Ruxandra-Oana, CHROBOCZEK, Tomasz, DAVIDO, Benjamin, DECONINCK, Laurène, DE TRUCHIS, Pierre, LAGRANGE, Aurore, MAKHLOUFI, Sabrina, MATT, Morgan, MELLON, Guillaume, SENARD, Olivia, BENHAMOU, Daniel, CHAPUZET, Claire, CHAUFFREY, Laure, ETIENNE, Manuel, JOLY, Luc-Marie, OBSTOY, Bérengère, SALAUN, Mathieu, THIBERVILLE, Luc, TILLON, Julie, BOLLENS, Diane, BOTTERO, Julie, CAMPA, Pauline, COSQUERIC, Gäelle, LEFEBVRE, Bénédicte, OUAZENE, Zineb, PACANOWSKI, Jérôme, PATERON, Dominique, VALIN, Nadia, COMPAIN, Caroline, CORDEL, Hugues, DOUMENC, Benoit, FOIS, Elena, GAMBIER, Nicolas, KHUONG, Marie-Aude, PASQUALONI, Elisa, POUPARD, Marie, Dinh, Aurélien, Ropers, Jacques, Duran, Clara, Davido, Benjamin, Deconinck, Laurène, Matt, Morgan, Senard, Olivia, Lagrange, Aurore, Makhloufi, Sabrina, Mellon, Guillaume, de Lastours, Victoire, Bouchand, Frédérique, Mathieu, Emmanuel, Kahn, Jean-Emmanuel, Rouveix, Elisabeth, Grenet, Julie, Dumoulin, Jennifer, Chinet, Thierry, Pépin, Marion, Delcey, Véronique, Diamantis, Sylvain, Benhamou, Daniel, Vitrat, Virginie, Dombret, Marie-Christine, Renaud, Bertrand, Perronne, Christian, Claessens, Yann-Erick, Labarère, José, Bedos, Jean-Pierre, Aegerter, Philippe, and Crémieux, Anne-Claude

Published
2021
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7. Predominance of healthcare-associated cases among episodes of community-onset bacteraemia due to extended-spectrum β-lactamase-producing Enterobacteriaceae

Author

Aissa, Nejla, Losniewski, Alain, Henard, Sandrine, Rabaud, Christian, Janssen, Cécile, Pagani, Léonardo, Bland, Stéphane, Gaillat, Jacques, Bru, Jean Pierre, Bonnin, Pierre, Clavère, Gaelle, Vitrat, Virginie, Maulin, Laurence, Quarsaet, Luc, Roger, Helene, Euzen, Jean-Baptiste, Denes, Eric, Couve-Daecon, Elodie, Lechiche, Catherine, Lavigne, Jean-Philippe, Mondain, Véronique, Pulcini, Celine, Garnier, Veronique, Lambert, Dorothée, Hentzien, Maxime, Nguyen, Yohan, Talarmin, Jean Paul, Rameau, Pascaline, Geffroy, Françoise, Salmon-Rousseau, Arnaud, Cattoir, Vincent, Froissart, Antoine, Aberrane, Said, Legout, Laurence, Roblot, France, Beraud, Guillaume, Pavese, Patricia, Belmonte, Olivier, Traversier, Nicolas, Bellec, Laurent, Lagrange-Xelot, Marie, Moiton, Marie-Pierre, Kuli, Barbara, Longuet, Pascal, Scanvic, Agnes, Colombain, Lea, Ferreyra, Milagros, Jean, Maxime, Eden, Aurelia, Laurens, Etienne, Saada, Matthieu, Aumaitre, Hugues, Malet, Martine, Roustant, Frederique, LeMoing, Vincent, Helene, Jean-Pierre, Theodore, Jonathan, Garandeau, Caroline, Caillon, Jocelyne, Olivero, Benjamin, Boutoille, David, Lepelletier, Didier, Grandière-Perez, Lucia, Beaudron, Aurélie, Ramanantsoa, Céline, Varache, Catherine, Varache, Nicolas, Crochette, Nicolas, Hitoto, Hikombo, Blanchi, Sophie, Penn, Pascale, Louis, Bernard, Vanjak, Dominique, Escande, Marie-Christine, Patrigeon, René-Gilles, Honoré, Stéphanie, Barrelet, Audrey, Amara, Marlène, Galempoix, Jean-Marc, Réveil, Jean-Claude, Bucchiotty, Patricia, Couzigou, Carine, LeMonnier, Alban, Boidin, Emilie, Sire, Stephane, Luizy, Nelly, Bronstain, Caroline, Harbarth, Stephan, Fankhauser, Carolina, Brossier, Caroline, von Dach, Elodie, Sauve, Colette, Adam, Marie-Noelle, Hocqueloux, Laurent, Bret, Laurent, André, Marie-Hélène, Barruet, Régine, Challier, Marion, Cabié, Andre, Roze, Benoit, Plesiat, Patrick, Jeanot, Katy, Patry, Isabelle, Moreau, Joséphine, Chirouze, Catherine, Laurent, Aaron, Bachelier, Marie-Nadège, Kac, Guillaume, Farthouat, Nicolas, Feuillebois, Nicolas, Guimard, Thomas, Bourdon, Sandra, Nguyen, Sophie, Alfandari, Serge, Bentayeb, Houcine, Albertini, Mari-Thérèse, Marchou, Bruno, Gaudré, Noémie, Dubois, Damien, Guillet-Caruba, Christelle, Doucet Populaire, Florence, Fortineau, Nicolas, Escaut, Leila, Lesprit, Philippe, Fihman, Vincent, Gauzit, Rémy, Raymond, Josette, Kerneis, Solene, Leflon-Guibout, Veronique, Lefort, Agnes, Dinh, Aurelien, Roux, Anne-Laure, Abgrall, Sophie, Jauréguy, Françoise, Lucet, Jean-Christophe, Soismier, Nathalie, Lopes, Amanda, Cambau, Emmanuelle, Manceron, Veronique, Barnaud, Guilène, Zahar, Jean-Ralph, Ruckly, Stephane, Hikombo, Hitoto, Bernard, Louis, Timsit, Jean-François, and Brun-Buisson, Christian

Published
2017
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9. Impact of vaccination on the presence and severity of symptoms of hospitalised patients with an infection by the Omicron variant (B.1.1.529) of the SARS-CoV-2 (subvariant BA.1)

Author

Beraud, Guillaume, primary, Bouetard, Laura, additional, Civljak, Rok, additional, Michon, Jocelyn, additional, Tulek, Necla, additional, Lejeune, Sophie, additional, Millot, Romain, additional, Garchet-Beaudron, Aurélie, additional, Lefebvre, Maeva, additional, Velikov, Petar, additional, Festou, Benjamin, additional, Abgrall, Sophie, additional, Lizatovic, Ivan Kresimir, additional, Baldolli, Aurélie, additional, Esmer, Huseyin, additional, Blanchi, Sophie, additional, Froidevaux, Gabrielle, additional, Kapincheva, Nikol, additional, Faucher, Jean-François, additional, Duvnjak, Mario, additional, Afşar, Elçin, additional, Švitek, Luka, additional, Yarimoglu, Saliha, additional, Yarimoglu, Rafet, additional, Janssen, Cécile, additional, and Epaulard, Olivier, additional

Published
2022
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11. A 4-days-on and 3-days-off maintenance treatment strategy for adults with HIV-1 (ANRS 170 QUATUOR): a randomised, open-label, multicentre, parallel, non-inferiority trial

Author

Landman, Roland, primary, de Truchis, Pierre, additional, Assoumou, Lambert, additional, Lambert, Sidonie, additional, Bellet, Jonathan, additional, Amat, Karine, additional, Lefebvre, Bénédicte, additional, Allavena, Clotilde, additional, Katlama, Christine, additional, Yazdanpanah, Yazdan, additional, Molina, Jean-Michel, additional, Petrov-Sanchez, Ventzislava, additional, Gibowski, Séverine, additional, Alvarez, Jean-Claude, additional, Leibowitch, Jacques, additional, Capeau, Jacqueline, additional, Fellahi, Soraya, additional, Duracinsky, Martin, additional, Morand-Joubert, Laurence, additional, Costagliola, Dominique, additional, Girard, Pierre-Marie, additional, LAMAURY, Isabelle, additional, BANI-SADR, Firouzé, additional, FORCE, Gilles, additional, CHABROL, Amélie, additional, CABY, Fabienne, additional, PATEY, Olivier, additional, FRESARD, Anne, additional, GAGNEUX-BRUNON, Amandine, additional, CHIROUZE, Catherine, additional, DUVIVIER, Claudine, additional, LOURENCO, Jérémie, additional, TOLSMA, Violaine, additional, JANSSEN, Cécile, additional, LEROLLE, Nathalie, additional, CATALAN, Pilartxo, additional, RAMI, Agathe, additional, DE PONTHAUD, Lucile, additional, PICHANCOURT, Gilles, additional, NASRI, Safa, additional, LANDOWSKI, Stéphanie, additional, BOTTERO, Julie, additional, MFUTILA KAYKAY, Flory, additional, PIALOUX, Gilles, additional, BOUCHAUD, Olivier, additional, ABGRALL, Sophie, additional, GATEY, Caroline, additional, WEISS, Laurence, additional, PAVIE, Juliette, additional, SALMON-CERON, Dominique, additional, ZUCMAN, David, additional, LELIEVRE, Jean-Daniel, additional, PALICH, Romain, additional, SIMON, Anne, additional, MEYOHAS, Marie-Caroline, additional, GRAS, Julien, additional, CABIE, André, additional, PIRCHER, Mathilde, additional, MORLAT, Philippe, additional, HESSAMFAR, Mojgam, additional, NEAU, Didier, additional, CAZENAVE, Charles, additional, GENET, Claire, additional, FAUCHER, Jean-François, additional, MAKHLOUFI, Djamila, additional, BOIBIEUX, André, additional, BREGIGEON-RONOT, Sylvie, additional, LAROCHE, Hélène, additional, SAUTEREAU, Aurélie, additional, REYNES, Jacques, additional, MAKINSON, Alain, additional, RAFFI, François, additional, BOLLENGIER-STRAGIER, Olivier, additional, NAQVI, Alissa, additional, CUA, Eric, additional, ROSENTHAL, Eric, additional, ARVIEUX, Cédrick, additional, BUZELE, Rodolphe, additional, REY, David, additional, BATARD, Marie-Laure, additional, BERNARD, Louis, additional, DELOBEL, Pierre, additional, PIFFAUT, Marie, additional, VERDON, Renaud, additional, PIROTH, Lionel, additional, BLOT, Mathieu, additional, LECLERCQ, Pascale, additional, SIGNORI-SCHMUCK, Anne, additional, HULEUX, Thomas, additional, MEYBECK, Agnès, additional, MAY, Thierry, additional, MIAILHES, Patrick, additional, PERPOINT, Thomas, additional, GREDER-BELAN, Alix, additional, ELHARRAR, Brigitte, additional, KHUONG, Marie-Aude, additional, POUPARD, Marie, additional, BLUM, Laurent, additional, MICHAU, Christophe, additional, PRAZUCK, Thierry, additional, PHILIBERT, Patrick, additional, SLAMA, Laurence, additional, HIKOMBO, Hitoto, additional, DARASTEANU, Iuliana, additional, GIRARD, Pierre-Marie, additional, ALVAREZ, Jean-Claude, additional, MATHEZ, Dominique, additional, DE TRUCHIS, Pierre, additional, LANDMAN, Roland, additional, MEYNARD, Jean-Luc, additional, MORAND-JOUBERT, Laurence, additional, LAMBERT, Sidonie, additional, LE DU, Damien, additional, PERRONNE, Christian, additional, ASSOUMOU, Lambert, additional, COSTAGLIOLA, Dominique, additional, MELCHIOR, Jean-Claude, additional, DURACINSKI, Martin, additional, PETROV-SANCHEZ, Ventzislava, additional, AMAT, Karine, additional, BENALYCHERIF, Aïda, additional, SYLLA, Babacar, additional, GELLEY, Ambre, additional, GIBOWSKI, Séverine, additional, LE MEUT, Guillaume, additional, THIEBAUT, Rodolphe, additional, CLUMECK, Nathan, additional, LECLERCQ, Vincent, additional, CECCHERINI-SILBERSTEIN, Francesca, additional, and DECOSTER, Laurent, additional

Published
2022
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12. Vaccination for Respiratory Infections in Patients with Heart Failure

Author

Fauroux, Brigitte, Khirani, Sonia, Amaddeo, Alessandro, MASSENAVETTE, Bruno, Bierme, Priscille, Taytard, Jessica, Stremler, Nathalie, Baravalle-Einaudi, Melisande, Mazenq, Julie, Ioan, Iulia, Schweitzer, Cyril, Lampin, Marie Emilie, Binoche, Alexandra, Mordacq, Clemence, Bergounioux, Jean, Mbieleu, Blaise, Rubinsztajn, Robert, Sigur, Elodie, Labouret, Geraldine, Genevois, Aline, Becourt, Arnaud, Hullo, Eglantine, Pin, Isabelle, Debelleix, Stéphane, Galodé, François, Bui, Stéphanie, Moreau, Johan, Renoux, Marie Catherine, Matecki, Stefan, Lavadera, Marc Lubrano, Heyman, Rachel, Pomedio, Michael, Le Clainche, Laurence, Bokov, Plamen, Masson, Alexandra, Hangard, Pauline, Menetrey, Celine, Jokic, Mikael, Gachelin, Elsa, Perisson, Caroline, Pervillé, Anne, Fina, Agnes, Giovannini-Chami, Lisa, Fleurence, Emmanuelle, Barzic, Audrey, Breining, Audrey, Ollivier, Morgane, Labbé, Guillaume, Coutier, Laurianne, Aubertin, Guillaume, Girerd, Nicolas, Chapet, Nicolas, Roubille, Camille, Roncalli, Jérôme, Salvat, Muriel, Mouquet, Frédéric, Lamblin, Nicolas, Gueffet, Jean-Pierre, Damy, Thibaud, Galinier, Michel, Tartiere, Jean-Michel, Janssen, Cécile, Berthelot, Emmanuelle, Aguilhon, Sylvain, Escamilla, Roger, Roubille, François, Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), CHU Toulouse [Toulouse], Centre Hospitalier Universitaire [Grenoble] (CHU), Hôpital Privé Le Bois Ramsay Santé [Lille], Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital privé du Confluent [Nantes], Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Henri Mondor, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Centre Hospitalier Intercommunal Toulon-La Seyne sur Mer - Hôpital Sainte-Musse, Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois], AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Université Paris-Sud - Paris 11 (UP11), Hôpital de Rangueil, Hôpital Privé Le Bois Ramsay Santé, Fédération des services de cardiologie [Rangueil], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], CHITS, CHU Montpellier, Hôpital Larrey [Toulouse], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10, Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université de Toulouse (UT), and MORNET, Dominique

Subjects
medicine.medical_specialty, pneumococcal vaccine, Influenza vaccine, [SDV]Life Sciences [q-bio], heart failure, review article, Disease, Review, 030204 cardiovascular system & hematology, medicine.disease_cause, law.invention, 03 medical and health sciences, respiratory infections, 0302 clinical medicine, Randomized controlled trial, law, Streptococcus pneumoniae, Medicine, 030212 general & internal medicine, Intensive care medicine, vaccination coverage, business.industry, General Medicine, medicine.disease, 3. Good health, Review article, [SDV] Life Sciences [q-bio], Vaccination, Pneumococcal vaccine, Heart failure, influenza vaccine, business, COVID-19 vaccine
Abstract

International audience; Bronchopulmonary infections are a major trigger of cardiac decompensation and are frequently associated with hospitalizations in patients with heart failure (HF). Adverse cardiac effects associated with respiratory infections, more specifically Streptococcus pneumoniae and influenza infections, are the consequence of inflammatory processes and thrombotic events. For both influenza and pneumococcal vaccinations, large multicenter randomized clinical trials are needed to evaluate their efficacy in preventing cardiovascular events, especially in HF patients. No study to date has evaluated the protective effect of the COVID-19 vaccine in patients with HF. Different guidelines recommend annual influenza vaccination for patients with established cardiovascular disease and also recommend pneumococcal vaccination in patients with HF. The Heart Failure group of the French Society of Cardiology recently strongly recommended vaccination against COVID-19 in HF patients. Nevertheless, the implementation of vaccination recommendations against respiratory infections in HF patients remains suboptimal. This suggests that a national health policy is needed to improve vaccination coverage, involving not only the general practitioner, but also other health providers, such as cardiologists, nurses, and pharmacists. This review first summarizes the pathophysiology of the interrelationships between inflammation, infection, and HF. Then, we describe the current clinical knowledge concerning the protective effect of vaccines against respiratory diseases (influenza, pneumococcal infection, and COVID-19) in patients with HF and finally we propose how vaccination coverage could be improved in these patients.

Published
2021
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14. Vaccination for Respiratory Infections in Patients with Heart Failure

Author

Girerd, Nicolas, primary, Chapet, Nicolas, additional, Roubille, Camille, additional, Roncalli, Jérôme, additional, Salvat, Muriel, additional, Mouquet, Frédéric, additional, Lamblin, Nicolas, additional, Gueffet, Jean-Pierre, additional, Damy, Thibaud, additional, Galinier, Michel, additional, Tartiere, Jean-Michel, additional, Janssen, Cécile, additional, Berthelot, Emmanuelle, additional, Aguilhon, Sylvain, additional, Escamilla, Roger, additional, and Roubille, François, additional

Published
2021
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15. Hesitancy towards COVID-19 Vaccination among Healthcare Workers: A Multi-Centric Survey in France

Author

Janssen, Cécile, Maillard, Alexis, Bodelet, Céline, Claudel, Anne-Laure, Gaillat, Jacques, Delory, Tristan, and Group, on behalf of the ACV Alpin Study

Subjects
0301 basic medicine, Coronavirus disease 2019 (COVID-19), Cross-sectional study, Immunology, Population, unsupervised learning, cross-sectional survey, Article, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Health care, Medicine, Pharmacology (medical), 030212 general & internal medicine, Adverse effect, education, Pharmacology, education.field_of_study, business.industry, healthcare workers, COVID-19, vaccination, Vaccination, 030104 developmental biology, Infectious Diseases, Immunization, Immunization program, hesitancy, business, Demography, clustering
Abstract

Vaccination programs against COVID-19 are being scaled up. We aimed to assess the effects of vaccine characteristics on vaccine hesitancy among healthcare workers in a multi-center survey conducted within French healthcare facilities from 1 December 2020 to 26 March 2021. We invited any healthcare workers naïve of COVID-19 vaccination to complete an online self-questionnaire. They reported on their socio-demographic characteristics, as well as their perception and beliefs towards vaccination. We measured their willingness to get vaccinated in eight scenarios for candidates’ vaccines presented sequentially (1 to 4-point scale). Candidates’ vaccines varied for efficacy (25%, 50%, 100%), length of immunization (1 year or lifetime), frequency (&lt, 1/100, &lt, 1/10,000), and severity (none, moderate, severe) of adverse events. We analyzed 4349 healthcare workers’ responses with interpretable questionnaires. The crude willingness to get vaccinated was 53.2% and increased over time. We clustered the trajectories of responses using an unsupervised classification algorithm (k-means) and identified four groups of healthcare workers: those willing to get vaccinated in any scenario (18%), those not willing to get vaccinated at all (22%), and those hesitating but more likely to accept (32%) or reject (28%) the vaccination depending on the scenario. In these last two subgroups, vaccine acceptance was growing with age, educational background and was higher among men with condition. Compared to an ideal vaccine candidate, a 50% reduced efficacy resulted in an average drop in acceptance by 0.8 (SD ± 0.8, −23.5%), while it was ranging from 1.4 (SD ± 1.0, −38.4%) to 2.1 (SD ± 1.0, −58.4%) in case of severe but rare adverse event. The acceptance of a mandatory immunization program was 29.6% overall and was positively correlated to the willingness to get vaccinated, ranging from 2.4% to 60.0%. Even if healthcare workers represent a heterogeneous population, most (80%) could accept the vaccination against COVID-19. Their willingness to get the vaccine increased over time and as immunization programs became available. Among hesitant professionals, the fear of adverse events was the main concern. Targeted information campaigns reassuring about adverse events may increase vaccine coverage, in a population with a strong opinion about mandatory immunization programs.

Published
2021
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18. Cluster of Coronavirus Disease 2019 (COVID-19) in the French Alps, February 2020

Author

Danis, Kostas, Epaulard, Olivier, Bénet, Thomas, Gaymard, Alexandre, Campoy, Séphora, Botelho-Nevers, Elisabeth, Bouscambert-Duchamp, Maude, Spaccaferri, Guillaume, Ader, Florence, Mailles, Alexandra, Boudalaa, Zoubida, Tolsma, Violaine, Berra, Julien, Vaux, Sophie, Forestier, Emmanuel, Landelle, Caroline, Fougere, Erica, Thabuis, Alexandra, Berthelot, Philippe, Veil, Raphael, Levy-Bruhl, Daniel, Chidiac, Christian, Lina, Bruno, Coignard, Bruno, Saura, Christine, Brottet, Elise, Casamatta, Delphine, Gallien, Yves, George, Scarlett, Viriot, Delphine, Ait Belghiti, Fatima, Bernard-Stoecklin, Sibylle, Desenclos, Jean-Claude, Giese, Coralie, Ghislain, Didier, Gounon, Magali, Grangeret, Nathalie, Marie, Cécile, Morel, Bruno, Deher, Muriel, Ronnaux Baron, Anne-Sophie, Courbis, Geneviève, Ragozin, Nathalie, Wolska, Monika, Serange, Eric, Mercatello, Delphine, Aiouaz, Soraya, Valette, Martine, Frobert, Emilie, Josset, Laurence, Escuret, Vanessa, Morfin, Florence, Billaud, Geneviève, Blanc, Myriam, Arata-Bardet, Julie, Froidure, Marie, Le Maréchal, Marion, Pavese, Patricia, Pierre, Isabelle, Becker, Agathe, Chauvelot, Pierre, Conrad, Anne, Ferry, Tristan, Miailhes, Patrick, Perpoint, Thomas, Pouderoux, Cécile, Roux, Sandrine, Valour, Florent, Lutz, Marie-France, Pouvaret, Anne, Vitrat, Virginie, Maillet, Mylène, Janssen, Cécile, Piet, Emilie, Bosch, Alexie, Destrem, Anne-Laure, Isnard, Margaux, Challan-Belval, Thibault, Wackenheim, Chloe, Couturier, Alice, Gheno, Gael, Roupioz, Thierry, Lucet, Nicolas, Ayouni, Stéphane, Vincent, Mireille, de Epidemiología, Servicio, General de Salud Pública del Gover Balear, Dirección, Masserey Spicher, Virginie, Bourquin, Catherine, Stoll, Jeanine, Chaud, Pascal, and Mounayar, Anne-Laure

Subjects
Microbiology (medical), Pediatrics, medicine.medical_specialty, Attack rate, Pneumonia, Viral, coronavirus, Disease cluster, Asymptomatic, 03 medical and health sciences, Betacoronavirus, 0302 clinical medicine, 030225 pediatrics, medicine, Major Article, Cluster Analysis, Humans, Serologic Tests, 030212 general & internal medicine, cluster, Index case, Pandemics, Aged, Retrospective Studies, Aged, 80 and over, Transmission (medicine), business.industry, SARS-CoV-2, COVID-19, Retrospective cohort study, Middle Aged, medicine.disease, infection, AcademicSubjects/MED00290, Infectious Diseases, Coinfection, Female, France, medicine.symptom, business, Coronavirus Infections, Viral load
Abstract

BackgroundOn 7 February 2020, French Health authorities were informed of a confirmed case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an Englishman infected in Singapore who had recently stayed in a chalet in the French Alps. We conducted an investigation to identify secondary cases and interrupt transmission.MethodsWe defined as a confirmed case a person linked to the chalet with a positive reverse-transcription polymerase chain reaction sample for SARS-CoV-2.ResultsThe index case stayed 4 days in the chalet with 10 English tourists and a family of 5 French residents; SARS-CoV-2 was detected in 5 individuals in France, 6 in England (including the index case), and 1 in Spain (overall attack rate in the chalet: 75%). One pediatric case, with picornavirus and influenza A coinfection, visited 3 different schools while symptomatic. One case was asymptomatic, with similar viral load as that of a symptomatic case. Seven days after the first cases were diagnosed, 1 tertiary case was detected in a symptomatic patient with from the chalet a positive endotracheal aspirate; all previous and concurrent nasopharyngeal specimens were negative. Additionally, 172 contacts were monitored; all contacts tested for SARS-CoV-2 (N = 73) were negative.ConclusionsThe occurrence in this cluster of 1 asymptomatic case with similar viral load as a symptomatic patient suggests transmission potential of asymptomatic individuals. The fact that an infected child did not transmit the disease despite close interactions within schools suggests potential different transmission dynamics in children. Finally, the dissociation between upper and lower respiratory tract results underscores the need for close monitoring of the clinical evolution of suspected cases of coronavirus disease 2019.

Published
2020
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19. Discontinuing β-lactam treatment after 3 days for patients with community-acquired pneumonia in non-critical care wards (PTC): a double-blind, randomised, placebo-controlled, non-inferiority trial

Author

Dinh, Aurélien, primary, Ropers, Jacques, additional, Duran, Clara, additional, Davido, Benjamin, additional, Deconinck, Laurène, additional, Matt, Morgan, additional, Senard, Olivia, additional, Lagrange, Aurore, additional, Makhloufi, Sabrina, additional, Mellon, Guillaume, additional, de Lastours, Victoire, additional, Bouchand, Frédérique, additional, Mathieu, Emmanuel, additional, Kahn, Jean-Emmanuel, additional, Rouveix, Elisabeth, additional, Grenet, Julie, additional, Dumoulin, Jennifer, additional, Chinet, Thierry, additional, Pépin, Marion, additional, Delcey, Véronique, additional, Diamantis, Sylvain, additional, Benhamou, Daniel, additional, Vitrat, Virginie, additional, Dombret, Marie-Christine, additional, Renaud, Bertrand, additional, Perronne, Christian, additional, Claessens, Yann-Erick, additional, Labarère, José, additional, Bedos, Jean-Pierre, additional, Aegerter, Philippe, additional, Crémieux, Anne-Claude, additional, ATTAL-BEHAR, Julie, additional, BEAUNE, Sébastien, additional, CHINET, Thierry, additional, CUDENNEC, Tristan, additional, DE LAROCHE, Marine, additional, DE THEZY, Albane, additional, DUMOULIN, Jennifer, additional, DUPONT, Caroline, additional, FERCOT, Elise, additional, GIRAUT, Violaine, additional, GREFFE, Ségolène, additional, GRENET, Julie, additional, GUYOT, Caroline, additional, KAHN, Jean-Emmanuel, additional, LABRUNE, Sylvie, additional, LACHATRE, Marie, additional, MOULIAS, Sophie, additional, NALINE, Charlotte, additional, PEPIN, Marion, additional, ROUVEIX, Elisabeth, additional, SAHUT-D'IZARN, Marine, additional, SEFSSAFI, Abel, additional, TEILLET, Laurent, additional, BRU, Jean-Pierre, additional, GAILLAT, Jacques, additional, GAUTIER, Vincent, additional, JANSSEN, Cécile, additional, PAGANI, Leonardo, additional, VITRAT, Virginie, additional, ABDERRAHMANE, Malika, additional, CAMUSET, Juliette, additional, LEGALL, Catherine, additional, LONGUET-FLANDRES, Pascale, additional, MENN, Anne-Marie, additional, DE LASTOURS, Victoire, additional, LECRONIER, Marie, additional, PREVOST, Gwenolée, additional, BURDET, Charles, additional, DERRADJI, Ouda, additional, ESCAUT, Lelia, additional, HINGLAIS, Etienne, additional, LEBRAS, Philippe, additional, LEFEVRE, Edouard, additional, NOAILLON, Mathilde, additional, RABIER, Pauline, additional, RAPHAEL, Maurice, additional, TEICHER, Elina, additional, VERNY, Christiane, additional, VITTECOQ, Daniel, additional, WYPLOSZ, Benjamin, additional, BEN HAYOUN, Michèle, additional, BRUN-VEZINET, Françoise, additional, CASALINO, Enrique, additional, CHOQUET, Christophe, additional, DOMBRET, Marie-Christine, additional, DUVAL, Xavier, additional, HOUHOU, Nadhira, additional, JOLY, Véronique, additional, LESCURE, Xavier, additional, POGLIAGHI, Manuela, additional, RIOUX, Christophe, additional, YAZDANPANAH, Yazdan, additional, BARROS, Elsa, additional, BEGGA, Belinda, additional, BOUKOBZA, Sébastien, additional, BOUREDJI, Houria, additional, CHOUAHI, Imad, additional, DELACROIX, Isabelle, additional, FROISSART, Antoine, additional, GARRAIT, Valérie, additional, NGWEM, Elsa, additional, PHLIPPOTEAU, Catherine, additional, SALEHABADI, Sepehr, additional, TOPER, Cécile, additional, VINAS, Florent, additional, AMSILLI, Marie, additional, EPAULARD, Olivier, additional, PAVESE, Patricia, additional, PIERRE, Isabelle, additional, STAHL, Jean-Paul, additional, AULAGNIER, Jérôme, additional, CELERIER, Julie, additional, COJOCARIU, Roxana, additional, MATHIEU, Emmanuel, additional, RACHLINE, Charlotte, additional, SCHOINDRE, Yoland, additional, SENE, Thomas, additional, THIERRY, Christelle, additional, APARICIO, Caroline, additional, DELCEY, Véronique, additional, LOPES, Amanda, additional, MORGAND, Marjolaine, additional, SELLIER, Pierre, additional, SIMONEAU, Guy, additional, CHAKVETADZE, Catherine, additional, DIAMANTIS, Sylvain, additional, GAUTHIER, Arnaud, additional, JIDAR, Kaoutar, additional, JOURDAIN, Béatrice, additional, BOITIAUX, Jean-Francois, additional, DESCHAMPS, Patrick, additional, DEVAUD, Edouard, additional, PHILIPPE, Bruno, additional, CALIN, Ruxandra-Oana, additional, CHROBOCZEK, Tomasz, additional, DAVIDO, Benjamin, additional, DECONINCK, Laurène, additional, DE TRUCHIS, Pierre, additional, LAGRANGE, Aurore, additional, MAKHLOUFI, Sabrina, additional, MATT, Morgan, additional, MELLON, Guillaume, additional, SENARD, Olivia, additional, BENHAMOU, Daniel, additional, CHAPUZET, Claire, additional, CHAUFFREY, Laure, additional, ETIENNE, Manuel, additional, JOLY, Luc-Marie, additional, OBSTOY, Bérengère, additional, SALAUN, Mathieu, additional, THIBERVILLE, Luc, additional, TILLON, Julie, additional, BOLLENS, Diane, additional, BOTTERO, Julie, additional, CAMPA, Pauline, additional, COSQUERIC, Gäelle, additional, LEFEBVRE, Bénédicte, additional, OUAZENE, Zineb, additional, PACANOWSKI, Jérôme, additional, PATERON, Dominique, additional, VALIN, Nadia, additional, COMPAIN, Caroline, additional, CORDEL, Hugues, additional, DOUMENC, Benoit, additional, FOIS, Elena, additional, GAMBIER, Nicolas, additional, KHUONG, Marie-Aude, additional, PASQUALONI, Elisa, additional, and POUPARD, Marie, additional

Published
2021
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20. Immunogenicity and Reactogenicity of Heterologous and Homologous mRNA-1273 and BNT162b2 Vaccination: A Multicenter Non-Inferiority Randomized Trial

Author

Janssen, Cécile, primary, Cachanado, Marine, additional, Ninove, Laetitia, additional, Lachatre, Marie, additional, Michon, Jocelyn, additional, Epaulard, Olivier, additional, Maakaroun-Vermesse, Zoha, additional, Chidiac, Christian, additional, Laviolle, Bruno, additional, Aumaitre, Hugues, additional, Assaf, Ady, additional, Lacombe, Karine, additional, Schmidt-Mutter, Catherine, additional, Botelho-Nevers, Elisabeth, additional, Briere, Magali, additional, Boisson, Thomas, additional, Loubet, Paul, additional, Bienvenu, Boris, additional, Bouchaud, Olivier, additional, Touati, Amel, additional, Pereira, Christine, additional, Rousseau, Alexandra, additional, Berard, Laurence, additional, Montil, Melissa, additional, de Lamballerie, Xavier, additional, Simon, Tabassome, additional, Launay, Odile, additional, and Group, The ARNCOMBI Study, additional

Published
2021
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22. Trajectories of Hospitalization in COVID-19 Patients: An Observational Study in France

Author

Boëlle, Pierre-Yves, primary, Delory, Tristan, additional, Maynadier, Xavier, additional, Janssen, Cécile, additional, Piarroux, Renaud, additional, Pichenot, Marie, additional, Lemaire, Xavier, additional, Baclet, Nicolas, additional, Weyrich, Pierre, additional, Melliez, Hugues, additional, Meybeck, Agnès, additional, Lanoix, Jean-Philippe, additional, and Robineau, Olivier, additional

Published
2020
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23. Factors Associated With Severe Nonmeningitis Invasive Pneumococcal Disease in Adults in France

Author

Danis, Kostas, Varon, Emmanuelle, Lepoutre, Agnès, Janssen, Cécile, FORESTIER, Emmanuel, Epaulard, Olivier, N’Guyen, Yohan, Labrunie, Anaïs, Lanotte, Philippe, Lartigue, Marie-Frédérique, Gravet, Alain, Pelloux, Isabelle, CHAVANET, Pascal, Levy-Bruhl, Daniel, Ploy, Marie-Cecile, Gaillat, Jacques, Peloux, Isabelle, Haudour, Aurélie, Recule, Christine, Blachon, A, Petitprez, Hélène, Janssen, Céline, Vitrat, Virginie, Tremeaux, Pauline, Ducruet, J, Legout, Laurence, Sifaoui, Farid, Levast, Marion, Habet, Tarik, Telini, Charlotte, Fabre, Marc, Tixier, Anne, Vray, Isabelle, Guillaume, Mathilde, Henry, X, Verger, Pascale, Lebrun, Cécile, Carvalhoschneider, C, Bernard, Louis, Courtellemont, Laura, Guinard, Jerome, Gubavu, Camelia, Petillon, Camille, Brieu, Nathalie, Maulin, Laurence, Vernet-Garnier, Véronique, Launois, Claire, Nguyen, Yohan, Madoux, Yannick, Strady, Christophe, Noel, Franck, Pavel, Simona, Thouvenin, Maxime, Galempoix, Jean-Marc, Prieur, Natahlie, Mestrallet, Stéphanie, Zucchini, Laure, Tetu, Jennifer, Pechinnot, André, Texier, Anthony, Kisterman, Jean-Paul, Chapalain, Josephine, Simonin, Catherine, Paleau, A, Benoit, Martha, Podac, Bianca, Desserrey, Agathe Ogier, Poirot, Jerome, Gautier, Guillaume, Mootien, Joy, Saraceni, Orlando, Mohareb, Abdo, Centre Hospitalier Intercommunal de Créteil (CHIC), Service de Médecine interne, Maladies Infectieuses et Immunologie Clinique [Reims], Centre Hospitalier Universitaire de Reims (CHU Reims), Observatoires Régionaux du Pneumocoque, Partenaires INRAE, Département d'hépato-gastro-entérologie [Hôpital Trousseau : CHRU Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours, Centre Hospitalier Emile Muller [Mulhouse] (CH E.Muller Mulhouse), Groupe Hospitalier de Territoire Haute Alsace (GHTHA), Hôpital du Bocage, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques (RESINFIT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges, Santé publique France - French National Public Health Agency [Saint-Maurice, France], Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois], Centre Hospitalier Métropole Savoie [Chambéry], Centre Hospitalier Universitaire [Grenoble] (CHU), Plate forme de bioinformatique et biostatistique (CEBIMER), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), The study was supported by (i) the Societe de Pathologie Infectieuse de Langue Francaise (SPILF, the French Infectious Diseases Society), (ii) Sante Publique France (SpFrance, the French National Public Health Agency), (iii) the European Centre for Disease Prevention and Control (ECDC), and (iv) Pfizer. The Regional Observatories of Pneumococci (Observatoires Regionaux du Pneumocoque) were supported by Pfizer, BioMerieux, and Sanofi., and Université de Tours-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
0301 basic medicine, medicine.medical_specialty, [SDV]Life Sciences [q-bio], 030106 microbiology, invasive pneumococcal disease, Pneumococcal conjugate vaccine, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Internal medicine, Acute care, Major Article, medicine, 030212 general & internal medicine, business.industry, medicine.disease, mortality, Pneumococcal polysaccharide vaccine, Intensive care unit, 3. Good health, pneumococcal conjugate vaccine, Vaccination, Streptococcus pneumoniae, Infectious Diseases, Oncology, Pneumococcal vaccine, Relative risk, surveillance, outcome, business, Meningitis, medicine.drug
Abstract

Background In France, pneumococcal vaccination in adults is recommended for risk groups (chronic conditions/immunosuppression). We conducted a study on invasive pneumococcal disease (IPD) in adults to identify factors associated with disease severity and death. Methods We included IPD cases, excluding meningitis, from 25 acute care hospitals in 6 regions. We defined severe cases as those with shock or severe sepsis or intensive care unit admission/mechanical ventilation. We included deaths occurring within 30 days of hospitalization. Infectious disease specialists collected clinical/microbiological data on cases. Results During 2014–2017, 908 nonmeningitis IPD cases were diagnosed; 48% were severe, 84% had comorbidities, 21% died. Ninety percent of cases with comorbidities who previously sought health care were not vaccinated against pneumococcus. Compared with previously healthy cases, the risk of severe IPD increased from 20% (adjusted risk ratio [aRR], 1.2; 95% confidence interval [CI], 1.0–1.4) in cases with 1–2 chronic diseases to 30% (aRR, 1.3; 95% CI, 1.0–7.0) in those with >2 chronic diseases. Among risk groups, 13-valent pneumococcal conjugate vaccine (PCV13) serotypes and 23-valent pneumococcal polysaccharide vaccine (PPSV23) nonPCV13 serotypes were more likely to induce severe IPD compared with nonvaccine serotypes (aRR, 1.5; 95% CI, 1.3–1.9; aRR, 1.3; 95% CI, 1.0–1.5, respectively). Conclusions We observed a cumulative effect of concurrent comorbidities on severe IPD. Vaccine serotypes were more likely to induce severe IPD among risk groups. The missed opportunities for vaccination underscore the need to enhance vaccination in risk groups.

Published
2019
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25. Predominance of healthcare-associated cases among episodes of community-onset bacteraemia due to extended-spectrum β-lactamase-producing Enterobacteriaceae

Author

Zahar, Jean-Ralph, primary, Lesprit, Philippe, additional, Ruckly, Stephane, additional, Eden, Aurelia, additional, Hikombo, Hitoto, additional, Bernard, Louis, additional, Harbarth, Stephan, additional, Timsit, Jean-François, additional, Brun-Buisson, Christian, additional, Aissa, Nejla, additional, Losniewski, Alain, additional, Henard, Sandrine, additional, Rabaud, Christian, additional, Janssen, Cécile, additional, Pagani, Léonardo, additional, Bland, Stéphane, additional, Gaillat, Jacques, additional, Bru, Jean Pierre, additional, Bonnin, Pierre, additional, Clavère, Gaelle, additional, Vitrat, Virginie, additional, Maulin, Laurence, additional, Quarsaet, Luc, additional, Roger, Helene, additional, Euzen, Jean-Baptiste, additional, Denes, Eric, additional, Couve-Daecon, Elodie, additional, Lechiche, Catherine, additional, Lavigne, Jean-Philippe, additional, Mondain, Véronique, additional, Pulcini, Celine, additional, Garnier, Veronique, additional, Lambert, Dorothée, additional, Hentzien, Maxime, additional, Nguyen, Yohan, additional, Talarmin, Jean Paul, additional, Rameau, Pascaline, additional, Geffroy, Françoise, additional, Salmon-Rousseau, Arnaud, additional, Cattoir, Vincent, additional, Froissart, Antoine, additional, Aberrane, Said, additional, Legout, Laurence, additional, Roblot, France, additional, Beraud, Guillaume, additional, Pavese, Patricia, additional, Belmonte, Olivier, additional, Traversier, Nicolas, additional, Bellec, Laurent, additional, Lagrange-Xelot, Marie, additional, Moiton, Marie-Pierre, additional, Kuli, Barbara, additional, Longuet, Pascal, additional, Scanvic, Agnes, additional, Colombain, Lea, additional, Ferreyra, Milagros, additional, Jean, Maxime, additional, Laurens, Etienne, additional, Saada, Matthieu, additional, Aumaitre, Hugues, additional, Malet, Martine, additional, Roustant, Frederique, additional, LeMoing, Vincent, additional, Helene, Jean-Pierre, additional, Theodore, Jonathan, additional, Garandeau, Caroline, additional, Caillon, Jocelyne, additional, Olivero, Benjamin, additional, Boutoille, David, additional, Lepelletier, Didier, additional, Grandière-Perez, Lucia, additional, Beaudron, Aurélie, additional, Ramanantsoa, Céline, additional, Varache, Catherine, additional, Varache, Nicolas, additional, Crochette, Nicolas, additional, Hitoto, Hikombo, additional, Blanchi, Sophie, additional, Penn, Pascale, additional, Louis, Bernard, additional, Vanjak, Dominique, additional, Escande, Marie-Christine, additional, Patrigeon, René-Gilles, additional, Honoré, Stéphanie, additional, Barrelet, Audrey, additional, Amara, Marlène, additional, Galempoix, Jean-Marc, additional, Réveil, Jean-Claude, additional, Bucchiotty, Patricia, additional, Couzigou, Carine, additional, LeMonnier, Alban, additional, Boidin, Emilie, additional, Sire, Stephane, additional, Luizy, Nelly, additional, Bronstain, Caroline, additional, Fankhauser, Carolina, additional, Brossier, Caroline, additional, von Dach, Elodie, additional, Sauve, Colette, additional, Adam, Marie-Noelle, additional, Hocqueloux, Laurent, additional, Bret, Laurent, additional, André, Marie-Hélène, additional, Barruet, Régine, additional, Challier, Marion, additional, Cabié, Andre, additional, Roze, Benoit, additional, Plesiat, Patrick, additional, Jeanot, Katy, additional, Patry, Isabelle, additional, Moreau, Joséphine, additional, Chirouze, Catherine, additional, Laurent, Aaron, additional, Bachelier, Marie-Nadège, additional, Kac, Guillaume, additional, Farthouat, Nicolas, additional, Feuillebois, Nicolas, additional, Guimard, Thomas, additional, Bourdon, Sandra, additional, Nguyen, Sophie, additional, Alfandari, Serge, additional, Bentayeb, Houcine, additional, Albertini, Mari-Thérèse, additional, Marchou, Bruno, additional, Gaudré, Noémie, additional, Dubois, Damien, additional, Guillet-Caruba, Christelle, additional, Doucet Populaire, Florence, additional, Fortineau, Nicolas, additional, Escaut, Leila, additional, Fihman, Vincent, additional, Gauzit, Rémy, additional, Raymond, Josette, additional, Kerneis, Solene, additional, Leflon-Guibout, Veronique, additional, Lefort, Agnes, additional, Dinh, Aurelien, additional, Roux, Anne-Laure, additional, Abgrall, Sophie, additional, Jauréguy, Françoise, additional, Lucet, Jean-Christophe, additional, Soismier, Nathalie, additional, Lopes, Amanda, additional, Cambau, Emmanuelle, additional, Manceron, Veronique, additional, and Barnaud, Guilène, additional

Published
2017
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26. Erratum to ‘Predominance of healthcare-associated cases among episodes of community-onset bacteraemia due to extended-spectrum β-lactamase-producing Enterobacteriaceae’ [International Journal of Antimicrobial Agents 49/1 67–73]

Author

Brun-Buisson, Christian, Carlet, Jean, Dellamonica, Pierre, Gauzit, Remy, Rabaud, Christian, Zahar, Jean-Ralph, Timsit, Jean-Francois, Alfandari, Serge, Cohen, Robert, Coignard, Bruno, Pulcini, Celine, Robert, Jerome, Aissa, Nejla, Losniewski, Alain, Henard, Sandrine, Janssen, Cecile, Pagani, Leonardo, Bland, Stephane, Gaillat, Jacques, Bru, Jean Pierre, Bonnin, Pierre, Clavere, Gaelle, Vitrat, Virginie, Maulin, Laurence, Quarsaet, Luc, Roger, Helene, Euzen, Jean-Baptiste, Denes, Eric, Couve-Daecon, Elodie, Lechiche, Catherine, Lavigne, Jean-Philippe, Mondain, Veronique, Garnier, Veronique, Lambert, Dorothee, Hentzien, Maxime, Nguyen, Yohan, Talarmin, Jean Paul, Rameau, Pascaline, Geffroy, Francoise, Salmon-Rousseau, Arnaud, Cattoir, Vincent, Froissart, Antoine, Aberrane, Said, Legout, Laurence, Roblot, France, Beraud, Guillaume, Pavese, Patricia, Belmonte, Olivier, Traversier, Nicolas, Bellec, Laurent, Lagrange-Xelot, Marie, Moiton, Marie-Pierre, Kuli, Barbara, Longuet, Pascal, Scanvic, Agnes, Colombain, Lea, Ferreyra, Milagros, Jean, Maxime, Eden, Aurelia, Laurens, Etienne, Saada, Matthieu, Aumaitre, Hugues, Malet, Martine, Roustant, Frederique, LeMoing, Vincent, Helene, Jean-Pierre, Theodore, Jonathan, Garandeau, Caroline, Caillon, Jocelyne, Olivero, Benjamin, Boutoille, David, Lepelletier, Didier, Grandiere-Perez, Lucia, Beaudron, Aurelie, Ramanantsoa, Celine, Varache, Catherine, Varache, Nicolas, Crochette, Nicolas, Hitoto, Hikombo, Blanchi, Sophie, Penn, Pascale, Louis, Bernard, Vanjak, Dominique, Escande, Marie-Christine, Patrigeon, Rene-Gilles, Honore, Stephanie, Barrelet, Audrey, Amara, Marlene, Galempoix, Jean-Marc, Reveil, Jean-Claude, Bucchiotty, Patricia, Couzigou, Carine, LeMonnier, Alban, Boidin, Emilie, Sire, Stephane, Luizy, Nelly, Bronstain, Caroline, Harbarth, Stephan, Fankhauser, Carolina, Brossier, Caroline, von Dach, Elodie, Sauve, Colette, Adam, Marie-Noelle, Hocqueloux, Laurent, Bret, Laurent, Andre, Marie-Helene, Barruet, Regine, Challier, Marion, Cabie, Andre, Roze, Benoit, Plesiat, Patrick, Jeanot, Katy, Patry, Isabelle, Moreau, Josephine, Chirouze, Catherine, Laurent, Aaron, Bachelier, Marie-Nadege, Kac, Guillaume, Farthouat, Nicolas, Feuillebois, Nicolas, Guimard, Thomas, Bourdon, Sandra, Nguyen, Sophie, Bentayeb, Houcine, Albertini, Mari-Therese, Marchou, Bruno, Gaudre, Noemie, Dubois, Damien, Guillet-Caruba, Christelle, Populaire, Florence Doucet, Fortineau, Nicolas, Escaut, Leila, Lesprit, Philippe, Fihman, Vincent, Raymond, Josette, Kerneis, Solene, Leflon-Guibout, Veronique, Lefort, Agnes, Dinh, Aurelien, Roux, Anne-Laure, Abgrall, Sophie, Jaureguy, Francoise, Lucet, Jean-Christophe, Soismier, Nathalie, Lopes, Amanda, Cambau, Emmanuelle, Manceron, Veronique, Barnaud, Guilene, Ruckly, Stephane, Hikombo, Hitoto, and Bernard, Louis

Published
2017
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28. Is Intrapartum Intravenous Zidovudine for Prevention of Mother-to-Child HIV-1 Transmission Still Useful in the Combination Antiretroviral Therapy Era?

Author

Briand, Nelly, primary, Warszawski, Josiane, additional, Mandelbrot, Laurent, additional, Dollfus, Catherine, additional, Pannier, Emmanuelle, additional, Cravello, Ludovic, additional, Nguyen, Rose, additional, Matheron, Isabelle, additional, Winer, Norbert, additional, Tubiana, Roland, additional, Rouzioux, Christine, additional, Faye, Albert, additional, Blanche, Stéphane, additional, Meier, Françoise, additional, Duro, Dominique, additional, Joras, Marine, additional, Mortier, Emmanuel, additional, Crenn-Hebert, Catherine, additional, Floch-Tudal, Corinne, additional, Mazy, Fabienne, additional, Bensalah, Mariam, additional, Villemant-Uludag, Agnès, additional, Lefort, Agnès, additional, Zarrouk, Virginie, additional, Ceccaldi, Pierre-François, additional, Philip, Gisèle, additional, Hittinger, Gilles, additional, Malet, Martine, additional, Bachelard, Bruno, additional, Medus, Marie, additional, Dendale-Nguyen, Joëlle, additional, Brossier, Jean-Pierre, additional, Aubry, Olivier, additional, Esnault, Jean-Luc, additional, Leautez, Sophie, additional, Perré, Philippe, additional, Suaud, Isabelle, additional, Martha, Sandrine-Anne, additional, Rouha, Mahfoud, additional, Perfezou, Pascale, additional, Blondin, Gilles, additional, Bellot, Charles, additional, Ansart, Séverine, additional, Le Moine, Philippe, additional, Bages-Jaffuel, Karine, additional, Duthé, Jean-Charles, additional, Garré, Michel, additional, Jaffuel, Sylvain, additional, Daniel, Corinne, additional, Calvez, Christian, additional, Beuscart, Claude, additional, Boutaric, Emmanuelle, additional, Rohan, Jennifer, additional, Lemoal, Sylvie, additional, Lassel, Linda, additional, Cotten, Ghislaine, additional, Dupré, Christelle, additional, Beauville, Esther, additional, Arvieux, Cédric, additional, Dos Santos, Anabèle, additional, Cudeville, Corinne, additional, Poinsignon, Yves, additional, Mouton-Rioux, Virginie, additional, Mousset, Gaétane, additional, Grellier, Anne, additional, Moreau, Philippe, additional, Tillaut, Philippe, additional, Luycx-Vaillant, Odile, additional, de Morel, Philippe, additional, Le Coz, Marie-Françoise, additional, Belzic, Isabelle, additional, Niault, Mathilde, additional, Vandenbergh, Anne, additional, Janssen, Cécile, additional, Braig, Susanne, additional, Vitrat, Virginie, additional, Gaillat, Jacques, additional, Clavere, Gaëlle, additional, Bru, Jean-Pierre, additional, Peyret, Blandine, additional, Mullard, Catherine, additional, Echard, Marie, additional, Talon, Philippe, additional, Dehlinger, Marion, additional, Winter, Cécile, additional, Heller-Roussin, Brigitte, additional, Launay, Odile, additional, Fouchet, Maria, additional, Firtion, Ghislaine, additional, Goupil, Isabelle, additional, Boudjoudi, Nora, additional, Bourgeois-Moine, Agnès, additional, Bodard, Marylène, additional, Vivier, Valérie, additional, Rajguru, Mandovi, additional, Huri, Virginie, additional, Azria, Elie, additional, Matheron, Sophie, additional, Elaoun, Neila, additional, Faucher, Philippe, additional, Garrait, Valérie, additional, Komme, Christiane, additional, Hau, Isabelle, additional, Richier, Laurent, additional, Touboul, Claudine, additional, Thoirain, Valérie, additional, Cotte, Laurent, additional, Tariel, Olivier, additional, Koffi, Joseph, additional, Labaune, Jean-Marc, additional, Brochier, Corinne, additional, Roux, Denis, additional, Elleau, Christophe, additional, Runel, Camille, additional, Bataille, Henri, additional, Sow, Marie-Thérèse, additional, Samar, Ketty, additional, Muanza, Blandine, additional, Duval, Marc, additional, Kingue-Ekollo, Clarisse, additional, Carpentier, Bénédicte, additional, Ronda, Isabelle, additional, Chamouilli, Jean-Marc, additional, Entz-Werle, Natacha, additional, Seaume, Hervé, additional, Ducrocq, Sarah, additional, Bailly-Salin, Philippe, additional, Lemercier, Yvon, additional, Tricoire, Joëlle, additional, Berrebi, Alain, additional, Antras, Michèle, additional, Armand, Evelyne, additional, Cayla, Claudine, additional, Bonnal, François, additional, Chabanier, Catherine, additional, Chacé, Anne, additional, Couderc, Sophie, additional, Boutemy, Anne, additional, Dallot, Marie-Christelle, additional, Al-Issa, Alain, additional, Routier, Corinne, additional, Zakaria, Ahmed, additional, Favret, Véronique, additional, Gerbe, Juliette, additional, Questiaux, Elisabeth, additional, Partisani, MariaLuisa, additional, Rey, David, additional, Cheneau, Christine, additional, Allisy, Christine, additional, Brault, Dominique, additional, Hervé, François, additional, Lebrette, Marie-Gisèle, additional, Selleret, Lise, additional, Ekoukou, Dieudonné, additional, Bolot, Pascal, additional, Khuong-Josses, Marie-Aude, additional, Allemon, Marie-Christine, additional, Ghibaudo, Nelly, additional, Frange, Pierre, additional, Veber, Florence, additional, Lemercier, Delphine, additional, Mourey, Marie-Christine, additional, Blasquez, Gilles, additional, Granier, Michèle, additional, Touahri, Houda, additional, Devidas, Alain, additional, Nisand, Israël, additional, Weil, Michèle, additional, Vayssière, Christophe, additional, Berger, Jean-Luc, additional, Munzer, Martine, additional, Graesslin, Olivier, additional, Naime-Alix, Anne-Florence, additional, Quetin, Frédérique, additional, Laubies, Anne, additional, Bonmarchand, Manuela, additional, Sommer, Jennifer, additional, Bourse, Patricia, additional, Coursol, Anne, additional, Youssef, Michel, additional, Laurent, Juliette, additional, Raho, Mariem, additional, Chambrin, Véronique, additional, Labrune, Philippe, additional, Clech, Laure, additional, Benachi, Alexandra, additional, Le Lorier, Bertrand, additional, Pauly-Ravelly, Isolde, additional, Allouche, Claude, additional, Johnson, Ama, additional, Benoist, Laurence, additional, Delannoy, Catherine, additional, Lachassine, Eric, additional, Bolie, Stéphanie, additional, Gaudelus, Joël, additional, Jeantils, Vincent, additional, Benabara, Amelie, additional, Karaoui, Leïla, additional, Lefèvre, Véronique, additional, Bongain, André, additional, Galiba, Eliane, additional, Deville, Anne, additional, Monpoux, Fabrice, additional, Durant, Jacques, additional, Aufrant, Christian, additional, Furioli, Jean, additional, Salomon, Jean-Louis, additional, Granier, Françoise, additional, Doumet, Antoine, additional, Douadi, Youssef, additional, Gondry, Jean, additional, Schmit, Jean-Luc, additional, Pautard, Brigitte, additional, Gamerre, Marc, additional, Thuret, Isabelle, additional, Neimann, Laurence, additional, Hubert, Claire, additional, Carbonne, Bruno, additional, Vaudre, Geneviève, additional, Tabone, Marie-Dominique, additional, Pinquier, Didier, additional, Pinto Cardoso, Gaëlle, additional, Clavier, Brigitte, additional, Borsa-Lebas, Françoise, additional, De Lauzanne, Agathe, additional, Borie, Constance, additional, Leveillé, Sandrine, additional, Bellaton, Erianna, additional, Garion, Dominique, additional, Levine, Martine, additional, Colmant, Claire, additional, Goujard, Cécile, additional, Tardieu, Marc, additional, Fuchs, Florent, additional, Jrad, Ikram, additional, Peretti, Delphine, additional, Bourdic, Katia, additional, Fourcade, Corinne, additional, Chirouze, Catherine, additional, Estavoyer, Jean-Marie, additional, Maillet, Robert, additional, Reliquet, Véronique, additional, Brunet, Cécile, additional, Reynaud, Isabelle, additional, Briandet, Claire, additional, Brouard, Jacques, additional, Beucher, Gaël, additional, Goubin, Pascale, additional, Lanty, Cécile, additional, Froguel, Eric, additional, Gourdel, Béatrice, additional, Chalvon Demersay, Arnaud, additional, Algava, Gilbert, additional, Hentgen, Véronique, additional, Messaoudi, Fabienne, additional, Nau, Pascale, additional, Besnier, Jean-Marc, additional, Potin, Jérôme, additional, Taché, Nadine, additional, Bertrand, Yves, additional, Kebaïli, Kamila, additional, Ronat, Véronique, additional, Fresard, Anne, additional, Billiemaz, Kareen, additional, Abrudan, Ramona, additional, Fournié, Alain, additional, Chennebault, Jean-Marie, additional, Arsac, Philippe, additional, Ciraru-Vigneron, Nicole, additional, Mouchnino, Geneviève, additional, Ayral, Dominique, additional, Guigue, Nelly, additional, Lalande, Muriel, additional, Benos, Paul, additional, De Gennes, Christiane, additional, Chanzy, Sonia, additional, Isart, Valérie, additional, Cazassus, François, additional, Walter, Véronique, additional, Bissuel, François, additional, Hammou, Yamina, additional, d'Angelo, Sophie, additional, Ajana, Faïza, additional, Mazingue, Françoise, additional, Mezin, Raymond, additional, Hatchuel, Yves, additional, Cabié, André, additional, and Elenga, Narcisse, additional

Published
2013
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29. Optimizing antimicrobial therapy in critically ill patients.

Author

Vitrat, Virginie, Hautefeuille, Serge, Janssen, Cécile, Bougon, David, Sirodot, Michel, and Pagani, Leonardo

Subjects
ANTI-infective agents, CRITICALLY ill, CRITICAL care medicine, DRUG resistance in bacteria, GRAM-negative bacteria, PHARMACOKINETICS, PHARMACODYNAMICS, MEDICAL care
Abstract

Critically ill patients with infection in the intensive care unit (ICU) would certainly benefit from timely bacterial identification and effective antimicrobial treatment. Diagnostic techniques have clearly improved in the last years and allow earlier identification of bacterial strains in some cases, but these techniques are still quite expensive and not readily available in all institutions. Moreover, the ever increasing rates of resistance to antimicrobials, especially in Gram-negative pathogens, are threatening the outcome for such patients because of the lack of effective medical treatment; ICU physicians are therefore resorting to combination therapies to overcome resistance, with the direct consequence of promoting further resistance. A more appropriate use of available antimicrobials in the ICU should be pursued, and adjustments in doses and dosing through pharmacokinetics and pharmacodynamics have recently shown promising results in improving outcomes and reducing antimicrobial resistance. The aim of multidisciplinary antimicrobial stewardship programs is to improve antimicrobial prescription, and in this review we analyze the available experiences of such programs carried out in ICUs, with emphasis on results, challenges, and pitfalls. Any effective intervention aimed at improving antibiotic usage in ICUs must be brought about at the present time; otherwise, we will face the challenge of intractable infections in critically ill patients in the near future. [ABSTRACT FROM AUTHOR]

Published
2014
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31. Assessing the economic impact and healthcare resource utilization of inpatient pneumococcal disease among adults: a French national claims database study.

Author

Bailey MD, Farge G, Breau Brunel M, Mohanty S, Roy G, de Pouvourville G, de Wazieres B, Janssen C, Tauty S, Bugnard F, Goguillot M, Bénard S, and Johnson KD

Abstract

Introduction: Pneumococcal diseases (PD) caused by Streptococcus pneumoniae include invasive PD (IPD) and non-bacteremia pneumococcal pneumonia (NBPP). Current French vaccination guidelines FOCUS on patients with underlying medical conditions (UMC) who are at a higher risk of PD. This study describes the healthcare resource utilization (HCRU) and economic burden of inpatient PD in French adults, to inform vaccination guidelines, especially among vulnerable subpopulations at increased risk of PD., Methods: A retrospective study utilizing the French administrative healthcare database (SNDS) was conducted among adults with a inpatient PD episode between 2015 and 2018. HCRU and costs were described per inpatient PD episode, according to patient risk level, type of PD, and age group., Results: Between 2015 and 2018, 42,466 inpatient PD episodes were identified. Most of inpatient PD episodes (73.8%) occurred in patients with UMCs. The median (Q1-Q3) cost per inpatient PD episode seemed higher among medium-risk patients (€14,863 (€7,875 - €30,434)) than among low-risk (€11,034 (€5,803 - €23,098)) and high-risk patients (€13,258 (€7,143 - €26,815)). Cost per inpatient PD episode did not seem to increase steadily with age, however, ≥65 patients represented 59.5% of all inpatient PD episodes and 52.3% of the overall inpatient PD episodes cost (€548,224,569 out of €1,049,214,069)., Limitations: Due to constraints of the SNDS dataset, results are limited to inpatient episodes of PD and may not be representative of all PD episodes in France., Conclusion: This large, retrospective study highlights a substantial economic burden associated with inpatient PD in France, especially among individuals with UMCs and those aged 65 years or over. These results emphasize the need to improve prevention strategies, especially among older patients, regardless of their risk level.

Published
2025
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32. Ceftaroline for the treatment of prosthetic valve endocarditis due to methicillin-resistant Staphylococcus aureus.

Author

Pagani L, Bonnin P, Janssen C, Desjoyaux E, Vitrat V, and Bru JP

Subjects
Aged, Endocarditis, Bacterial diagnosis, Endocarditis, Bacterial microbiology, Frail Elderly, Humans, Male, Prosthesis-Related Infections diagnosis, Prosthesis-Related Infections microbiology, Staphylococcal Infections diagnosis, Staphylococcal Infections microbiology, Treatment Outcome, Ceftaroline, Anti-Bacterial Agents administration & dosage, Cephalosporins administration & dosage, Endocarditis, Bacterial drug therapy, Heart Valve Prosthesis adverse effects, Heart Valve Prosthesis Implantation adverse effects, Heart Valve Prosthesis Implantation instrumentation, Methicillin-Resistant Staphylococcus aureus isolation & purification, Prosthesis-Related Infections drug therapy, Staphylococcal Infections drug therapy
Abstract

The case is described of a frail patient who developed prosthetic valve endocarditis due to methicillin-resistant Staphylococcus aureus (MRSA). Conventional antimicrobial treatments either failed or were contraindicated, and the patient was judged unsuitable for a further valve replacement. A salvage therapy with high doses of a new cephalosporin, ceftaroline, given three times daily was undertaken; subsequently, the patient had not relapsed at two months after completing a six-week course of ceftaroline. Ceftaroline deserves major attention as an alternative choice in difficult-to-treat MRSA endocarditis.

Published
2014

33. [Vaccinations].

Author

Marchand-Janssen C and Verdon R

Subjects
Contraindications, Humans, Immunization Schedule, Vaccination, Vaccines adverse effects, Vaccines immunology
Published
2011

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