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13 results on '"J.L. Sebert"'

1. Non-aluminic adynamic bone disease in non-dialyzed uremic patients: A new type of osteopathy due to overtreatment?

Author

A. Marie, B. Boudailliez, Martine Cohen-Solal, P.F. Westeel, J.L. Sebert, A. Fournier, M. Garabedian, and P. Moriniere

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Histology, Calcitriol, Bone disease, Hypoparathyroidism, Physiology, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Urology, Renal function, Asymptomatic, Calcium Carbonate, Renal Dialysis, Internal medicine, Humans, Medicine, Dialysis, Calcifediol, Uremia, business.industry, Osteoid, Middle Aged, medicine.disease, Endocrinology, Female, Bone Diseases, Osteitis, medicine.symptom, business, Aluminum, medicine.drug
Abstract

Adynamic bone disease, characterized by a low bone formation rate with normal or reduced amount of unmineralized osteoid, is supposed to be the consequence of aluminum intoxication in uremic patients. However, the emergence of adynamic bone disease has been recently reported in hemodialyzed patients in the total absence of aluminum overload. This study was aimed to assess whether such a histological pattern of adynamic bone disease was already present in uremic patients not yet on dialysis. Twenty-seven asymptomatic uremic patients (mean age +/- SD 43 +/- 10 years, mean creatinine clearance 19 +/- 3 ml/mm) were studied and bone biopsies were repeated in 16 of them after 18 +/- 10 months of treatment with oral calcium carbonate (1-3 g of elemental calcium/day) and calcidiol (21 +/- 14 micrograms/day). None of the patients received aluminum hydroxide, and the search for bone aluminum deposits was negative in all patients both before and after treatment. Two patients fulfilled the criteria of adynamic bone disease on their post-treatment biopsies. They originated from patients classified as having normal bone histology before treatment. Comparison with the other patients showed that they had comparable plasma C-terminal PTH but higher plasma creatinine than patients with normal bone histology and lower plasma C-terminal PTH than patients with osteitis fibrosa but comparable plasma creatinine. The plasma levels of 1,25(OH)2D reached values above normal after treatment in these two patients. It is suggested that adynamic bone disease not related to aluminum intoxication can develop in uremic patients independently of dialysis, and is favored by a relative hypoparathyroidism for the degree of renal failure, possibly induced by elevated plasma concentrations of calcitriol.

Published
1992
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2. Percutaneous vertebroplasty with acrylic cement in the treatment of osteoporotic vertebral crush fracture syndrome

Author

Claude Debussche-Depriester, P. Fardellone, L. Cartz, J.L. Sebert, H. Deramond, A. Heleg, and P. Galibert

Subjects
Cement, medicine.medical_specialty, Percutaneous, business.industry, medicine.medical_treatment, Osteoporosis, medicine.disease, Percutaneous biopsy, Vertebra, Surgery, Percutaneous vertebroplasty, medicine.anatomical_structure, medicine, Severe pain, business, Collapsed vertebra
Abstract

Vertebral fractures, spontaneous or due to minor trauma are classical complications of osteoporosis. Fractures are often painful, requiring analgesia and immobilisation for some weeks; immobilisation, however, has a negative effect on mineralisation. In order to consolidate the collapsed vertebra and relieve symptoms, the authors have developed a new therapy, percutaneous in-trasomatic injection of acrylic cement, which was initially proposed for the cure of aggressive spinal angiomas. After percutaneous biopsy of the vertebra, a 10 gauge needle is inserted in its body and a mixture of tantalum powder and methyl-methacrylate (3–5 cc) paste is injected. Five patients with severe pain due to osteoporotic vertebral crush fracture syndrome were successfully treated by this method. The technique and results are detailed.

Published
1991
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3. Résonance magnétique nucléaire et spondylodiscite

Author

C. Le Fouille-Ribeyre, C. Gondry, P. Toussaint, Amar Smail, J. Delcour, K. Masmoudi, J.P. Ducroix, A. Rudelli, J.L. Sebert, and J. Baillet

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Gastroenterology, Internal Medicine, medicine, Vertebral osteomyelitis, Magnetic resonance imaging, Radiology, equipment and supplies, business, medicine.disease, human activities
Abstract

Magnetic resonance imaging permits an early diagnosis in vertebral osteomyelitis but puncture of the disc for bacteriological examination remains an indication of the C.T. scan.

Published
1992
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4. Limit by hypherphosphatemia ofthe usefulness of vitamin D metabolites (1α-hydroxycholecalciferol and 25-hydroxycholecalciferol) in the treatment of renal osteodystrophy

Author

J. Gueris, Pierre J. Meunier, Quichaud J, J.L. Sebert, A. Smadja, R. Makdassi, J. F. de Fremont, Pierre J. Marie, Lambrey G, D. Kuntz, Fournier A, A. Ryckewaert, and A. Marie

Subjects
Hyperparathyroidism, medicine.medical_specialty, Osteomalacia, business.industry, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Urology, chemistry.chemical_element, Calcium, medicine.disease, Hyperphosphatemia, Endocrinology, chemistry, Internal medicine, medicine, Vitamin D and neurology, 25 hydroxycholecalciferol, Surgery, Renal osteodystrophy, business, Dialysis
Abstract

Nineteen patients who had been on maintenance hemodialysis for 33 months ,(± 13) with conditions optimized to prevent renal osteodystrophy (3 times week, a dialysate calcium of 7.0 mg/dl, oral calcium supplement and aluminum hydroxide to correct hypocalcemia and hyperphosphatemia, but with no vitamin D supplement) were treated with 1-alpha-HCC and 25-HCC (daily dosage of 1 and 50 μg respectively) for one year. This treatment was stopped every time the predialytic plasma levels of calcium and/or phosphate rose above 11.0 and 7.0 mg/di respectively in spite of an Increase in the prescribed dosage of aluminum hydroxide, and was resumed after normalization of plasma calcium and/or phosphate at reduced doses. The effect of vitamin D therapy was mainly assessed by histomorphometric evaluation of bone biopsies performed before initiating the treatment and 6 to 12 months later. Initially, no patient had histological evidence of osteomalacia as assessed by osteoid thickness Index, in spite of low plasma 25-HCC levels in 10 15 patients. 14 19 had hyperparathyroidism with extended active resorption surfaces (ARS) which were positively correlated with plasma PTH levels. During treatment, no patient developed osteomatacia. ARS Improved in 6 patients, worsened in 7 and remained unchanged In the 6 others, including 3 with initially normal values. When comparing worsened versus Improved patients, the aggravation of osteltis fibrosa was associated with increasing levels of plasma phosphate and pPTH. It is concluded that addition of vitamin D derivatives to optimal dialysis condlitions seems of questionable value because : 1) optimal dialysis conditions alone adequately prevent osteomalacla and most radiological osteitis fibrosa ; 2) vitamin D metabolite therapy may make plasma phosphate control more difficult which contributes to worsening of residual hyperparathyrodism.

Published
1980
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5. Contents, Vol. 39, 1985

Author

N.C. Kramer, P. Bonvicini, Pedro Frommer, Loris Borghi, S. Dündar, Shaul G. Massry, J. Griño, Edwina A. Brown, J. Guéris, Naoyasu Sugishita, Yasuhito Saito, W. Kramer, Takao Suga, J.L. Sebert, Courtney Klingensmith, K.-G. Post, Kishore Phadke, P. Amodio, Anthony D. Nicastri, Edward T. Zawada, Donald I. Feinstein, T. Sözen, N D Markandu, M. Maxwell., A. Gatta, Jean-François de Frémont, Giorgio Graziani, J.E. McLure, T. Funke, A. Oktay, Masayuki Endoh, Laura W. Fleming, Akira Shinoda, L. S. Ibels, Murray Epstein, Diethard Gemsa, James B. Young, Anthony W. Stanson, Elettra Lorenzano, A. Schwarz, P.B. Bataille, A. Brulles, Jürgen Bommer, Isao Ishikawa, Claudio Ponticelli, M. Hervé, A. Fournier, Raymond F. Raper, Carlos Ayus, L. Dornfeld, Isabelle Grégoire, Julius M. Cruse, I. Grégoire, A.M. Thompson, Giuseppe A. Sagnella, Donald E. Engen, Isabella Simoni, A. Abraham, L. Milani, Rene Verberckmoes, M. Molzahn, J. Andreu, R. Romero, Ann James, M. Tuck, Nelly Ledême, W.K. Stewart, George P. Hemstreet, Wayne C. Waltzer, Robert B. Francis, Hirohisa Kitada, Rodger Loutzenhiser, Shizuko Suzuki, E. Ancona, Albert Fournier, Bruno Coevoet, Patrick Fievet, P. Morinière, Zengoro Onouchi, P. Rigotti, Geneviève Charransol, Paul Michielsen, Sylvester Sterioff, Ian C. Anderson, G. Bazzerla, J. Matin-Comin, Horst Zincke, C. Pagnini-Arslan, M.A. Oto, Eberhard Ritz, S. Dosa, P.J. Malony, L.O. Simpson, G. Schütterle, Pierre Bataille, Charles Horton, Josy Martens, Orlando Adamson, Myriam Finet, M. Johnson, Dilip Sen, T.M. Phillips, Alberto Cantaluppi, Graham A. MacGregor, Keita Tateishi, André Pruna, Hideto Sakai, F. Keller, Alberto Montanari, A. Caralps, Robert L. Chevalier, Glen L. Feye, A. Leflon, Rodney M. Sandier, Eben I. Feinstein, Anne A.A. Halliday, V. Wizemann, Daniel Levitan, Barbara E. Jones, Yoshihiro Fukuda, S. Arıoğul, Almerico Novarini, Joachim Kessler, C.K. Chen, Robert E. Lewis, Amir Tejani, and Didier Hauglustaine

Subjects
Traditional medicine, business.industry, Medicine, business
Published
1985
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6. Contents, Vol. 34, 1983

Author

Dimitrios G. Oreopoulos, Yuji Nagura, G. Decaux, T. Bertani, Michinobu Hatano, Minoru Harada, Hiroyuki Ohi, Thomas G. Murray, A. Martínez Amenós, Patricio Silva, S. Garancini, B. Maziere, Ann Locniskar, A. De Mouzon Cambon, L. Carreras, George E. Digenis, S. Rabinovich, P. Moriniere, H. Rama, Hans H. Koepke, Nobuyuki Yoshizawa, N.P. Mallick, P.J. Meuniere, Barry R. Walker, J.C. Ansquer, G. Lagrue, N. Duquesnoy, J. Alsina, Lazaro Gotloib, J. Manos, Koichi Matsumoto, Alan Medline, Seymour Rosen, J.L. Sebert, Allen Sugarman, S. Abu-Regiaba, Hisashi Katayama, L. Ballada, David M. Roxe, Robert S. Brown, S. Glasberg, L. Olesnicky, David J. Greenblatt, C.D. Short, Takayuki Fujita, Kotaro Osakabe, J. Laurent, Patricia R. Audet, G. Roncari, A. Fournier, A. Caralps, Subramanyam Santhanam, C.L. Pirani, I. Dumont, D. Kuntz, and L. Gastaldi

Subjects
Traditional medicine, business.industry, Medicine, business
Published
1983
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7. Effect of thyrotoxicosis and its treatment on mineral and bone metabolism

Author

J. Quichaud, J. D. Lalau, J.L. Sebert, A. Fournier, and A. Marie

Subjects
Adult, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, chemistry.chemical_element, Calcium, Bone and Bones, Bone resorption, Phosphates, Bone remodeling, Excretion, Endocrinology, Internal medicine, medicine, Humans, Aged, Calcium metabolism, Minerals, business.industry, Thyroid, Blood Proteins, Middle Aged, Resorption, Thyrotoxicosis, medicine.anatomical_structure, chemistry, Parathyroid Hormone, Creatinine, Female, business, Hormone
Abstract

Mineral metabolism and bone histomorphometric status were evaluated in 31 hyperthyroid patients (HT) without clinical or radiological bone disease, both before and after treatment of hyperthyroidism. Blood and urine biochemical data were compared with those obtained in sex and age-matched controls. Iliac bone biopsies were available from 12 untreated HT and from 6 of them after treatment for analysis of trabecular bone. Mean plasma calcium was increased in HT but true hypercalcemia was seen in only one case and mean plasma immunoreactive parathormone (iPTH) was normal. Urine calcium excretion was markedly increased, especially in the fasting state. Biochemical parameters decreased after treatment, except for serum alkaline phosphatase and iPTH that, respectively, remained high and increased. Untreated state was characterized by an hyperremodelling state with enhanced activities of bone formation and bone resorption. Bone mineralization was normal. The mineral and bone changes were related to serum thyroid hormone levels. After treatment, the extent of formation surfaces still increased. The fact that, even though calcium metabolism abnormalities were corrected, active resorption surfaces did not change, suggests that trabecular osteoclastic resorption is not an important cause of mobilization of bone calcium to extracellular fluids in HT.

Published
1986
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8. Comparative effects of dialysis with cuprophan versus polyacrylonitrile membranes on plasma immunoreactive parathyroid hormone levels in patients on chronic hemodialysis

Author

J.L. Sebert, C. Ferriere, Quichaud J, J. F. de Fremont, B. Covoet, J. Gueris, and Fournier A

Subjects
Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Acrylic Resins, Radioimmunoassay, Parathyroid hormone, Phosphates, chemistry.chemical_compound, Endocrinology, Renal Dialysis, Internal medicine, Nitriles, medicine, Humans, Orthopedics and Sports Medicine, In patient, Chronic hemodialysis, Cellulose, Dialysis, business.industry, Polyacrylonitrile, Membranes, Artificial, General Medicine, Middle Aged, Membrane, chemistry, Parathyroid Hormone, Calcium, Female, Kidney Diseases, business, Copper
Published
1977

9. Assessment of the aluminum overload and of its possible toxicity in asymptomatic uremic patients: evidence for a depressive effect on bone formation

Author

J.L. Sebert, J. Gueris, A. Fournier, M.A. Herve, A. Smadja, A. Marie, Michèle Garabédian, and Leflon P

Subjects
Adult, Male, medicine.medical_specialty, Pathology, Histology, Physiology, Endocrinology, Diabetes and Metabolism, Ultrafiltration, Gastroenterology, Asymptomatic, Bone and Bones, Osteogenesis, Renal Dialysis, Internal medicine, medicine, Humans, Bone formation, Bone Resorption, Vitamin D, Aged, Uremia, business.industry, Middle Aged, Blood, Parathyroid Hormone, Toxicity, Osteomalacia, Female, medicine.symptom, business, Aluminum
Published
1985

10. Subject Index, Vol. 34, 1983

Author

D. Kuntz, L. Gastaldi, S. Garancini, A. De Mouzon Cambon, Hiroyuki Ohi, B. Maziere, G. Decaux, J. Laurent, Patricia R. Audet, S. Glasberg, Robert S. Brown, P.J. Meuniere, S. Abu-Regiaba, David M. Roxe, Hans H. Koepke, L. Carreras, G. Lagrue, C.L. Pirani, J.C. Ansquer, J. Alsina, Alan Medline, I. Dumont, Allen Sugarman, A. Caralps, Yuji Nagura, Subramanyam Santhanam, J. Manos, George E. Digenis, Barry R. Walker, Patricio Silva, David J. Greenblatt, Seymour Rosen, G. Roncari, Koichi Matsumoto, C.D. Short, A. Fournier, Kotaro Osakabe, Dimitrios G. Oreopoulos, Thomas G. Murray, A. Martínez Amenós, P. Moriniere, H. Rama, L. Ballada, Lazaro Gotloib, N.P. Mallick, T. Bertani, Michinobu Hatano, Minoru Harada, L. Olesnicky, Takayuki Fujita, S. Rabinovich, Nobuyuki Yoshizawa, N. Duquesnoy, Ann Locniskar, J.L. Sebert, and Hisashi Katayama

Subjects
Index (economics), business.industry, Statistics, Medicine, Subject (documents), business
Published
1983
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11. Subject Index, Vol. 39, 1985

Author

Dilip Sen, Glen L. Feye, Ian C. Anderson, Eben I. Feinstein, M. Molzahn, J. Matin-Comin, Horst Zincke, P.J. Malony, Alberto Cantaluppi, Daniel Levitan, André Pruna, Shaul G. Massry, V. Wizemann, T.M. Phillips, Hideto Sakai, Isabella Simoni, Laura W. Fleming, Graham A. MacGregor, M. Tuck, Naoyasu Sugishita, E. Ancona, Hirohisa Kitada, Yoshihiro Fukuda, L.O. Simpson, Keita Tateishi, J.L. Sebert, T. Funke, Edwina A. Brown, J. Guéris, A.M. Thompson, Giuseppe A. Sagnella, Zengoro Onouchi, M. Hervé, Bruno Coevoet, Julius M. Cruse, Geneviève Charransol, A. Brulles, Diethard Gemsa, S. Arıoğul, Jürgen Bommer, Anthony W. Stanson, Elettra Lorenzano, George P. Hemstreet, R. Romero, Robert B. Francis, Masayuki Endoh, Charles Horton, Ann James, Josy Martens, Orlando Adamson, Carlos Ayus, A. Abraham, Nelly Ledême, J. Griño, Akira Shinoda, Donald E. Engen, M. Johnson, Rene Verberckmoes, J. Andreu, Paul Michielsen, Raymond F. Raper, Albert Fournier, L. Dornfeld, Anthony D. Nicastri, W. Kramer, Rodger Loutzenhiser, L. S. Ibels, Sylvester Sterioff, Shizuko Suzuki, F. Keller, Donald I. Feinstein, Claudio Ponticelli, G. Bazzerla, M.A. Oto, Isao Ishikawa, Eberhard Ritz, Patrick Fievet, S. Dosa, Pedro Frommer, Loris Borghi, G. Schütterle, P. Morinière, P. Rigotti, Myriam Finet, J.E. McLure, L. Milani, James B. Young, C. Pagnini-Arslan, S. Dündar, Pierre Bataille, K.-G. Post, A. Schwarz, Yasuhito Saito, Jean-François de Frémont, Isabelle Grégoire, T. Sözen, Takao Suga, N D Markandu, W.K. Stewart, Rodney M. Sandier, Wayne C. Waltzer, A. Gatta, Courtney Klingensmith, M. Maxwell., Kishore Phadke, Alberto Montanari, Edward T. Zawada, Barbara E. Jones, Giorgio Graziani, A. Oktay, Anne A.A. Halliday, Almerico Novarini, Robert L. Chevalier, A. Leflon, A. Caralps, A. Fournier, I. Grégoire, N.C. Kramer, P. Bonvicini, P. Amodio, Murray Epstein, P.B. Bataille, Joachim Kessler, C.K. Chen, Robert E. Lewis, Amir Tejani, and Didier Hauglustaine

Subjects
Index (economics), business.industry, Statistics, Medicine, Subject (documents), business
Published
1985
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