Author: "J.J. Martin" - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"J.J. Martin"' showing total 163 results

Start Over Author "J.J. Martin"

163 results on '"J.J. Martin"'

1. Correlation between biological responses in vitro and in vivo to Ca-doped sol-gel coatings assessed using proteomic analysis

Author: García-Arnáez, I., Romero-Gavilán, F., Cerqueira, A., Elortza, F., Azkargorta, M., Muñoz, F., Mata, M., de Llano, J.J. Martín, Suay, J., Gurruchaga, M., and Goñi, I.
Published: 2022
Full Text: View/download PDF

2. Screening non-conventional yeasts for organic acid tolerance and engineeringPichia occidentalisfor production ofcis,cis-muconic acid

Author: Michael E. Pyne, James A. Bagley, Lauren Narcross, Kaspar Kevvai, Kealan Exley, Meghan Davies, Qingzhao Wang, Malcolm Whiteway, and Vincent J.J. Martin
Abstract: Saccharomyces cerevisiae is a workhorse of industrial biotechnology owing to the organism’s prominence in alcohol fermentation and the suite of sophisticated genetic tools available to manipulate its metabolism. However, S. cerevisiae is not suited to overproduce many bulk bioproducts, as toxicity constrains production at high titers. Here we employ a high-throughput assay to screen 108 publicly accessible yeast strains for tolerance to 20 g L−1adipic acid (AA), a nylon precursor. We identify 15 tolerant yeasts and select Pichia occidentalis for production of cis,cis-muconic acid (CCM), a precursor to AA. By developing a genome editing toolkit for P. occidentalis, we demonstrate fed-batch production of CCM with a maximum titer (38.8 g L−1), yield (0.134 g g−1glucose) and productivity (0.511 g L−1h−1) that surpasses all metrics achieved using S. cerevisiae. This work brings us closer to the industrial bioproduction of AA and underscores the importance of host selection in bioprocessing.
Published: 2023

3. CRAPS: Chromosomal-Repair-Assisted Pathway Shuffling in yeast

Author: Christien B. Dykstra, Michael E. Pyne, and Vincent J.J. Martin
Abstract: A fundamental challenge of metabolic engineering involves assembling and screening vast combinations of orthologous enzymes across a multi-step biochemical pathway. Current pathway assembly workflows involve combining genetic partsex vivoand assembling one pathway configuration per tube or well. Here we present CRAPS,Chromosomal-Repair-AssistedPathwayShuffling, anin vivopathway engineering technique that enables the self-assembly of one pathway configuration per cell. CRAPS leverages the yeast chromosomal repair pathway and utilizes a pool of inactive, chromosomally integrated orthologous gene variants corresponding to a target multi-step pathway. Supplying gRNAs to the CRAPS host activates the expression of one gene variant per pathway step, resulting in a unique pathway configuration in each cell. We deployed CRAPS to build more than 1,000 combinations of a four-step carotenoid biosynthesis network. Sampling the CRAPS pathway space yielded strains with distinct color phenotypes and carotenoid product profiles. We anticipate that CRAPS will expedite strain engineering campaigns by enabling the generation and sampling of vast biochemical spaces.
Published: 2023

4. Intrahepatic splenosis visualized on a [m99Tc]Tc-denatured erythrocyte scintigraphy

Author: S. Bondia Bescós, J.J. Martin Marcuartu, M.T. Bajén Lázaro, J. Mora Salvadó, A. Benítez Segura, and M. Cortés Romera
Subjects: General Engineering, General Earth and Planetary Sciences, General Environmental Science
Published: 2023

5. Esplenosis intrahepática visualizada en una gammagrafía con [99mTc]Tc-hematíes desnaturalizados

Author: S. Bondia Bescós, J.J. Martin Marcuartu, M.T. Bajén Lázaro, J. Mora Salvadó, A. Benítez Segura, and M. Cortés Romera
Subjects: Radiology, Nuclear Medicine and imaging
Published: 2023

6. Frequency and Patterns of Brain Infarction in Patients With Embolic Stroke of Undetermined Source: NAVIGATE ESUS Trial

Author: Mukul Sharma, Eric E. Smith, Lesly A. Pearce, Ashkan Shoamanesh, Kanjana S. Perera, Shelagh B. Coutts, Dorte Damgaard, Sebastian F. Ameriso, Joung-Ho Rha, Boris Modrau, Byung-Woo Yoon, Marina Romano, Steven R. Messé, Jessica Barlinn, Johann Lambeck, Feryal Saad, Scott D. Berkowitz, Hardi Mundl, Stuart J. Connolly, Robert G. Hart, T.S. Field, G.J. Stotts, D.J. Gladstone, S.J. Phillips, A. Sharrief, C. Holmstedt, N. Vora, C. Wilson, B.M. Coull, A. de Havenon, L.A. Birnbaum, N. Patel, M.S. Hussain, D. Greer, S. Chen, S. Kittner, D. Mehta, T. Lowenkopf, R. Sawyer, V. Babikian, R. Zweifler, D.L. Tirschwell, C. Sila, C. Zhang, K-S. Hong, K. Oh, J.H. Heo, H-J. Bae, M.S. Park, J.S. Kim, C-S. Chung, B-C. Lee, G.P. Povedano, J.J. Martin, G.M. Bruera, L.V. Jure, J. Marti-Fabregas, I.C. Naranjo, J.M.R. Moreno, P.C. Portela, M. Gomis, J. Serena, H. Christensen, T. Christensen, S. Knecht, M. Endres, J. Berrouschot, F. Schlachetzki, S. Wunderlich, P. Kraft, P. Guyler, RC. Veltkamp, M. Burn, K. Rashed, M.J. Macleod, C. Canepa, J. Selvarajah, D. Hargroves, Y. Behnam, T.G. Robinson, L. Roveri, G. Lembo, D.S. Toni, V. Monzani, A. Cavallini, D. Popov, M. Friedrich, C. Minelli, C. Moro, R.J. Gagliardi, A. Bacellar, R. Mikulik, J. Eckstein, G. Panczel, N. Szegedi, and M.J. O’Donnell
Subjects: Brain Infarction, Male, medicine.medical_specialty, Internationality, Tobacco use, Cohort Studies, Magnetic resonance imaging, Double-Blind Method, Rivaroxaban, Internal medicine, medicine, Humans, In patient, cardiovascular diseases, Aged, Advanced and Specialized Nursing, Aspirin, medicine.diagnostic_test, business.industry, Anti-Inflammatory Agents, Non-Steroidal, Middle Aged, Magnetic Resonance Imaging, Embolic stroke, Stroke, Intracranial Embolism, Brain infarction, Cardiology, Female, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, Factor Xa Inhibitors, medicine.drug
Abstract: Background and Purpose: The spectrum of brain infarction in patients with embolic stroke of undetermined source (ESUS) has not been well characterized. Our objective was to define the frequency and pattern of brain infarcts detected by magnetic resonance imaging (MRI) among patients with recent ESUS participating in a clinical trial. Methods: In the NAVIGATE ESUS trial (New Approach Rivaroxaban Inhibition of Factor Xa in a Global Trial Versus ASA to Prevent Embolism in Embolic Stroke of Undetermined Source), an MRI substudy was carried out at 87 sites in 15 countries. Participants underwent an MRI using a specified protocol near randomization. Images were interpreted centrally by those unaware of clinical characteristics. Results: Among the 918 substudy cohort participants, the mean age was 67 years and 60% were men with a median (interquartile range) of 64 (26–115) days between the qualifying ischemic stroke and MRI. On MRI, 855 (93%) had recent or chronic brain infarcts that were multiple in 646 (70%) and involved multiple arterial territories in 62% (401/646). Multiple brain infarcts were present in 68% (510/755) of those without a history of stroke or transient ischemic attack before the qualifying ESUS. Prior stroke/transient ischemic attack ( P 0 ( P P =0.01) were associated with multiple infarcts. Topographically, large and/or cortical infarcts were present in 89% (757/855) of patients with infarcts, while in 11% (98/855) infarcts were exclusively small and subcortical. Among those with multiple large and/or cortical infarcts, 57% (251/437) had one or more involving a different vascular territory from the qualifying ESUS. Conclusions: Most patients with ESUS, including those without prior clinical stroke or transient ischemic attack, had multiple large and/or cortical brain infarcts detected by MRI, reflecting a substantial burden of clinical stroke and covert brain infarction. Infarcts most frequently involved multiple vascular territories. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02313909.
Published: 2022

7. Divergent Directed Evolution of a TetR-type Repressor Towards Aromatic Molecules

Author: Mohamed A. Nasr, Vincent J.J. Martin, and David H. Kwan
Abstract: Reprogramming cellular behaviour is one of the hallmarks of synthetic biology. To this end, prokaryotic allosteric transcription factors (aTF) have been repurposed as versatile tools for processing small molecule signals into cellular responses. Expanding the toolbox of aTFs that recognize new inducer molecules is of considerable interest in many applications. Here, we first establish a resorcinol responsive aTF-based biosensor in Escherichia coli using the TetR-family repressor RolR from Corynebacterium glutamicum. We then perform an iterative walk along the fitness landscape of RolR to identify new inducer specificities, namely catechol, methyl catechol, caffeic acid, protocatechuate, L-DOPA, and the tumour biomarker homovanillic acid. Finally, we demonstrate the versatility of these engineered aTFs by transplanting them into the model eukaryote Saccharomyces cerevisiae. This work provides a framework for efficient aTF engineering to expand ligand specificity towards novel molecules on laboratory timescales, which, more broadly, is invaluable across a wide range of applications such as protein and metabolic engineering, as well as point-of-care diagnostics.
Published: 2022

8. Análisis dinámico muscular y de la estructura interna del nervio periférico como biomarcadores para la esclerosis lateral amiotrófica: estudio piloto mediante ecografía

Author: C. López-Navarro, M. Serrano-Valero, E.M. Fages-Caravaca, J.J. Martínez-Payá, M.E. del Baño-Aledo, and J. Ríos-Díaz
Subjects: Amyotrophic lateral sclerosis, Neuromuscular diseases, Biomarkers, Ultrasonography, Skeletal muscle, Peripheric nerves, Neurology. Diseases of the nervous system, RC346-429
Abstract: Resumen: Introducción: El objetivo del trabajo fue conocer el comportamiento de los biomarcadores ecográficos de densidad fascicular y fuerza muscular en pacientes con esclerosis lateral amiotrófica (ELA). Métodos: Estudio piloto, observacional y transversal sobre 14 pacientes con ELA (mujeres; 28,6%) y 14 controles. Se tomaron ecografías bilaterales transversales en el abductor corto del pulgar (ACP) y tibial anterior (TA) con registro del grosor muscular (GM) en reposo, en contracción y diferencia de engrosamiento. En los nervios mediano, ciático y peroneo común se analizaron el área de sección transversal (AST), el número de fascículos (NF) y la densidad fascicular (DF). Los análisis se realizaron anidados por lateralidad. Resultados: El acuerdo intra-interobservador en los recuentos de fascículos fue muy bueno con un error mínimo detectable
Published: 2024
Full Text: View/download PDF

9. Dynamic analysis of muscles and the internal structure of the peripheral nerve as biomarkers of amyotrophic lateral sclerosis: A pilot study with ultrasound imaging

Author: C. López-Navarro, M. Serrano-Valero, E.M. Fages-Caravaca, J.J. Martínez-Payá, M.E. del Baño-Aledo, and J. Ríos-Díaz
Subjects: Esclerosis lateral amiotrófica, Enfermedades neuromusculares, Biomarcadores, Ultrasonografía, Músculo esquelético, Nervios periféricos, Neurology. Diseases of the nervous system, RC346-429
Abstract: Introduction: The aim of this study was to determine the behaviour of ultrasound biomarkers of fascicle density and muscle strength in patients with amyotrophic lateral sclerosis (ALS). Methods: We conducted an observational, cross-sectional pilot study of 14 patients with ALS (28.6% women) and 14 controls. Bilateral cross-sectional ultrasound scans were performed in the abductor pollicis brevis (APB) and tibialis anterior (TA) muscles, with recording of muscle thickness (MT) at rest and in contraction, and the difference in thickness. In the median, sciatic, and common peroneal nerves, we analysed the cross-sectional area (CSA), number of fascicles (NF) and fascicle density (FD). Analyses were nested by laterality. Results: Intra- and interrater agreement regarding NF was very good, with a minimum detectable error of
Published: 2024
Full Text: View/download PDF

10. Evaluation of the diuretic activity of the ethanolic extract of Geranium seemannii Peyr. in Wistar rats

Author: Montejano-Rodríguez, José Ramón, Almaguer-Vargas, Georgina, Gayosso-De-Lucio, Juan Antonio, Ocharan Hernández, María Esther, Moreno Martínez, Reyna Erika, Hernández Caballero, Marta Elena, Torres-Valencia, J.J. Martín, and Sierra Ramírez, José Alfredo
Published: 2013
Full Text: View/download PDF

11. Photodissociation of S2 (X3Σg–, a1Δg, and b1Σg+) in the 320–205 nm Region

Author: Zahid Farooq, Patrick J.J. Martin, Colin M. Western, David H. Parker, and Zhong-Fa Sun
Subjects: 010304 chemical physics, Chemistry, Photodissociation, Ab initio, 010402 general chemistry, 7. Clean energy, 01 natural sciences, Quantum chemistry, Molecular physics, Potential energy, Spectral line, Article, 0104 chemical sciences, Photoexcitation, TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY, Excited state, 0103 physical sciences, Molecule, Physical and Theoretical Chemistry
Abstract: Photodissociation of vibrationally and electronically excited sulfur dimer molecules (S2) has been studied in a combined experimental and computational quantum chemistry study in order to characterize bound-continuum transitions. Ab initio quantum chemistry calculations are carried out to predict the potential energy curves, spin-orbit coupling, transition moments, and bound-continuum spectra of S2 for comparison with the experimental data. The experiment uses velocity map imaging to measure S-atom production following S2 photoexcitation in the ultraviolet region (320-205 nm). A pulsed electric discharge in H2S produces ground-state S2 X3ςg -(v = 0-15) as well as electronically excited singlet sulfur and b1ςg +(v = 0, 1), and evidence is presented for the production and photodissociation of S2 a1Δg. In a previous paper, we reported threshold photodissociation of S2X3ςg -(v = 0) in the 282-266 nm region. In the present study, S(3PJ) fine structure branching and angular distributions for photodissociation of S2 (X3ςg -(v = 0), a1Δg and b1ςg +) via the B″3IIu, B3ςu - and 11IIu excited states are reported. In addition, photodissociation of the X3ςg -(v = 0) state of S2 to the second dissociation limit producing S(3P2) + S(1D) is characterized. The present results on S2 photodynamics are compared to those of the well-studied electronically isovalent O2 molecule.
Published: 2019

12. Stroke

Author: Christina Jern, Martin Stenman, Tobias Brandt, Sandra Freitag-Wolf, Braxton D. Mitchell, Manja Kloss, Didier Leys, Jonathan Rosand, Stefan T. Engelter, Michael Krawczak, Steven J. Kittner, Vincent Thijs, Giacomo Giacalone, Daniel Woo, J.J. Martin, Jordi Jimenez-Conde, Philip Ginsbach, Emmanuel Touzé, Armin J. Grau, Elisabetta Del Zotto, Tiina M. Metso, Philipp Erhart, Eyad Hayani, Dorothea Pfeiffer, Christoph Lichy, I. Werner, Valeria Caso, Bowang Chen, Antti J. Metso, Caspar Grond-Ginsbach, Arne Lindgren, Shérine Abboud, Anna Bersano, Natalia S. Rost, Kristina Schlicht, Jane Maguire, John W. Cole, Robin Lemmens, Alessandro Pezzini, Jin-Moo Lee, Philippe Lyrer, Steve Bevan, Christopher Traenka, Stéphanie Debette, Turgut Tatlisumak, Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: DNA copy number variations, Neurology, Gene Dosage, Logistic regression, Severity of Illness Index, Brain Ischemia, 0302 clinical medicine, Modified Rankin Scale, Gene Duplication, Chromosomes, Human, genetics, Stroke, RISK, 0303 health sciences, Middle Aged, stroke, VINTAGE, Medical genetics, Cardiology and Cardiovascular Medicine, Life Sciences & Biomedicine, Adult, medicine.medical_specialty, Genotype, Clinical Neurology, Subgroup analysis, COPY-NUMBER VARIATION, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, Genetic imbalance, Internal medicine, OHNOLOGS, medicine, Humans, Aged, 030304 developmental biology, Advanced and Specialized Nursing, Science & Technology, Neurology & Neurosurgery, business.industry, GENOME-WIDE, Recovery of Function, Odds ratio, medicine.disease, Peripheral Vascular Disease, Cardiovascular System & Cardiology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neurosciences & Neurology, prognosis, Neurology (clinical), business, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract: Background and Purpose— We sought to explore the effect of genetic imbalance on functional outcome after ischemic stroke (IS). Methods— Copy number variation was identified in high-density single-nucleotide polymorphism microarray data of IS patients from the CADISP (Cervical Artery Dissection and Ischemic Stroke Patients) and SiGN (Stroke Genetics Network)/GISCOME (Genetics of Ischaemic Stroke Functional Outcome) networks. Genetic imbalance, defined as total number of protein-coding genes affected by copy number variations in an individual, was compared between patients with favorable (modified Rankin Scale score of 0–2) and unfavorable (modified Rankin Scale score of ≥3) outcome after 3 months. Subgroup analyses were confined to patients with imbalance affecting ohnologs—a class of dose-sensitive genes, or to those with imbalance not affecting ohnologs. The association of imbalance with outcome was analyzed by logistic regression analysis, adjusted for age, sex, stroke subtype, stroke severity, and ancestry. Results— The study sample comprised 816 CADISP patients (age 44.2±10.3 years) and 2498 SiGN/GISCOME patients (age 67.7±14.2 years). Outcome was unfavorable in 122 CADISP and 889 SiGN/GISCOME patients. Multivariate logistic regression analysis revealed that increased genetic imbalance was associated with less favorable outcome in both samples (CADISP: P =0.0007; odds ratio=0.89; 95% CI, 0.82–0.95 and SiGN/GISCOME: P =0.0036; odds ratio=0.94; 95% CI, 0.91–0.98). The association was independent of age, sex, stroke severity on admission, stroke subtype, and ancestry. On subgroup analysis, imbalance affecting ohnologs was associated with outcome (CADISP: odds ratio=0.88; 95% CI, 0.80–0.95 and SiGN/GISCOME: odds ratio=0.93; 95% CI, 0.89–0.98) whereas imbalance without ohnologs lacked such an association. Conclusions— Increased genetic imbalance was associated with poorer functional outcome after IS in both study populations. Subgroup analysis revealed that this association was driven by presence of ohnologs in the respective copy number variations, suggesting a causal role of the deleterious effects of genetic imbalance.
Published: 2019

13. 394P Preliminary tolerance analysis of adjuvant chemotherapy in older patients after resection of stage III colon adenocarcinoma from PRODIGE 34-FFCD 1402-ADAGE randomized phase III trial

Author: Thomas Aparicio, Sandrine Hiret, P.L. Etienne, R. Desgrippes, V. Lebrun-Ly, Y. Rinaldi, F. Hocine, L. Mineur, M. Pauwels, M. Van den Eynde, J.J. Martin, J. Cretin, Jérôme Desramé, Eric Terrebonne, L. Cany, Anthony Turpin, Emilie Barbier, Claire Falandry, O. Bouche, L. Mosser, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Service d'oncologie médicale, and UCL - (SLuc) Service d'hépato-gastro-entérologie
Subjects: Oncology, medicine.medical_specialty, business.industry, Adjuvant chemotherapy, Hematology, Resection, Older patients, Internal medicine, Medicine, Colon adenocarcinoma, Stage (cooking), business
Abstract: Background Colon adenocarcinoma occurs mainly in older patients (pts). Oxaliplatin based adjuvant chemotherapy has demonstrated an improvement on disease-free survival (DFS) after a stage III colon cancer resection in young pts. Nevertheless, the benefit of adjuvant chemotherapy is matter of debate in old pts. Methods The purpose of ADAGE trial is to compare the DFS obtain with oxaliplatin combined with fluoropyrimidine (F) to F alone in fit pts over 70 years (group 1) and F to observation in frail pts (group 2) after resection of a stage III colon cancer. We here report a preliminary tolerance analysis on 50% of the first pts enrolled in the study. Results The analysis was performed on 491 pts (378 in group 1 and 113 in group 2). Main pts characteristics were respectively for the group 1 and 2: male in 57% and 50%, median age of 76 and 83 years, ECOG=0 in 59% and 29%, abnormal IADL in 23% and 62%, no caregiver in 26% and 28%, fall ≤6 months in 9% and 14%, depression possible 28% and 40%, fail of one-leg balance in 20% and 59%, impaired cognition in 21% and 38%, G8 score
Published: 2021

14. Inusual case of Rosai-Dorfman disease in a 18F-FDG PET/CT study

Author: J.J. Martin-Marcuartu, M. Moreno-Caballero, J.J. Nava Mateos, P. Barquilla Cordero, R. Arenas Ore, and A. Martínez-Esteve
Subjects: General Engineering, General Earth and Planetary Sciences, General Environmental Science
Published: 2020

15. Serum Amyloid A Stimulates Vascular and Renal Dysfunction in Apolipoprotein E-Deficient Mice Fed a Normal Chow Diet

Author: Belal Chami, Farjaneh Hossain, Thomas W. Hambly, Xiaoping Cai, Roshanak Aran, Genevieve Fong, Abigail Vellajo, Nathan J.J Martin, XiaoSuo Wang, Joanne M. Dennis, Arpeeta Sharma, Waled A. Shihata, Jaye P. F. Chin-Dusting, Judy B. de Haan, Alexandra Sharland, Carolyn L. Geczy, Ben Freedman, and Paul K. Witting
Subjects: Male, 0301 basic medicine, Apolipoprotein E, Apolipoprotein B, Kidney Function Tests, Mice, chemistry.chemical_compound, 0302 clinical medicine, endothelial function, acute-phase protein, Immunology and Allergy, Medicine, Endothelial dysfunction, Aorta, Original Research, Mice, Knockout, Kidney, biology, Acute-phase protein, Immunohistochemistry, Lipids, medicine.anatomical_structure, Cytokines, Kidney Diseases, Disease Susceptibility, Inflammation Mediators, medicine.symptom, lcsh:Immunologic diseases. Allergy, medicine.medical_specialty, Immunology, Inflammation, 03 medical and health sciences, Apolipoproteins E, nitric oxide, renal dysfunction, Internal medicine, Animals, Serum amyloid A, Cyclic guanosine monophosphate, Peroxidase, Serum Amyloid A Protein, business.industry, Macrophages, Endothelial Cells, medicine.disease, Disease Models, Animal, 030104 developmental biology, Endocrinology, chemistry, inflammation, biology.protein, Blood Vessels, lcsh:RC581-607, business, Biomarkers, 030215 immunology
Abstract: Elevated serum amyloid A (SAA) levels may promote endothelial dysfunction, which is linked to cardiovascular and renal pathologies. We investigated the effect of SAA on vascular and renal function in apolipoprotein E-deficient (ApoE−/−) mice. Male ApoE−/− mice received vehicle (control), low-level lipopolysaccharide (LPS), or recombinant human SAA by i.p. injection every third day for 2 weeks. Heart, aorta and kidney were harvested between 3 days and 18 weeks after treatment. SAA administration increased vascular cell adhesion molecule (VCAM)-1 expression and circulating monocyte chemotactic protein (MCP)-1 and decreased aortic cyclic guanosine monophosphate (cGMP), consistent with SAA inhibiting nitric oxide bioactivity. In addition, binding of labeled leukocytes to excised aorta increased as monitored using an ex vivo leukocyte adhesion assay. Renal injury was evident 4 weeks after commencement of SAA treatment, manifesting as increased plasma urea, urinary protein, oxidized lipids, urinary kidney injury molecule (KIM)-1 and multiple cytokines and chemokines in kidney tissue, relative to controls. Phosphorylation of nuclear-factor-kappa-beta (NFκB-p-P65), tissue factor (TF), and macrophage recruitment increased in kidneys from ApoE−/− mice 4 weeks after SAA treatment, confirming that SAA elicited a pro-inflammatory and pro-thrombotic phenotype. These data indicate that SAA impairs endothelial and renal function in ApoE−/− mice in the absence of a high-fat diet.
Published: 2019

16. Father Sweet

Author: J.J. Martin and J.J. Martin
Subjects: Priests--Fiction, Child sexual abuse by clergy--Fiction
Abstract: A shocking tale of secrets, guilt, and clerical child abuse. “God has made you special, but I will show you how to have an extraordinary life. Show you true love, as God intended for our kind.” It's 1978. Blackburn Hamlet is a typical suburban village in eastern Ontario. In this vibrant Catholic community, life revolves around family and church. Then the safe comfort of both is destroyed by the arrival of a predator priest.When charismatic Father Sweet invites his new favourite altar boy on a camping trip, the boy's parents insist he go. Trapped in the woods, the boy struggles to evade the priest's sexual advances. But Father Sweet forces him to make an impossible choice.Twenty-five years later, he is lost, broken, and angry. His father's death reveals secrets that spur the man to relive his own past. Desiring justice, in need of healing, he discovers, in a daring rescue mission, a way to achieve both.
Published: 2019

17. La reina de África

Author: J.J. Martín and J.J. Martín
Abstract: Algunas cosas no son la realidad, pero merecerían serlo. Un grupo de prisioneros de un país occidental firman un acuerdo por el que las penas les serán suspendidas a cambio de trabajos para una ONG humanitaria de África. Pero unos inversores tienen pensado otra cosa muy diferente: caza furtiva de animales pagando sobornos, una pelea ilegal -celebrada en un lugar secreto- entre el león africano y un toro bravo por la que se cruzan fuertes apuestas. Un pequeño pueblo con sorpresa. Una reina, una mina. Y más que una novela, una historia diferente de otras muchas.
Published: 2018

18. A systematic literature review and network meta-analysis of treatments for patients with untreated multiple myeloma not eligible for stem cell transplantation

Author: Weisel, K. Doyen, C. Dimopoulos, M. Yee, A. Lahuerta, J.J. Martin, A. Travers, K. Druyts, E. Toor, K. Abildgaard, N. Lu, J. Van Droogenbroeck, J. Geraldes, C. Petrini, M. Voillat, L. Voog, E. Facon, T.
Abstract: In newly diagnosed multiple myeloma (MM), patients ineligible for front-line autologous stem cell transplantation (ASCT), melphalan and prednisone (MP) with thalidomide (MPT) or bortezomib (VMP) are standard first-line therapeutic options. Despite new treatment regimens incorporating bortezomib or lenalidomide, MM remains incurable. The FIRST study demonstrated significant improvement in progression-free survival (PFS) and overall survival (OS) for the combination of lenalidomide and low-dose dexamethasone (Rd) until progression vs. MPT in transplant-ineligible ndMM patients. However, to date no head-to-head randomized controlled trials (RCTs) have compared Rd or MPT versus VMP. We conducted a network meta-analysis using RCTs identified through a systematic literature review to evaluate the relative efficacy of Rd versus other regimens on survival endpoints in previously untreated MM patients ineligible for ASCT. In this analysis, Rd was associated with a significant PFS and survival advantage versus other first-line treatments (VMP, MPT, MP), challenging the role of alkylators in this setting. © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Published: 2017

19. Milan

Author: J.j., Martin
Subjects: Travel, recreation and leisure
Abstract: MILAN Milan is more than Italy's business capital or transit hub, an industry town living in the shadows of the more camera-ready Florence, Venice, and Rome. No one knows this [...]
Published: 2015

20. Laing early-onset distal myopathy in a Belgian family

Author: Bjarne Udd, J.J. Martin, P. Van den Bergh, Frédéric Lecouvet, and E. Schmedding
Subjects: Weakness, medicine.medical_specialty, Foot drop, Neurology, Belgium, Humans, Medicine, Muscle, Skeletal, Myopathy, Aged, Family Health, LAING DISTAL MYOPATHY, Myosin Heavy Chains, business.industry, General Medicine, Anatomy, Distal limb, Surgery, Distal Myopathies, Mutation, Female, MYH7, Human medicine, Neurology (clinical), medicine.symptom, business, Cardiac Myosins
Abstract: We report the first Belgian family with Laing early-onset distal myopathy (MPD1). The proposita started limping at age 7. Later, there was severe weakness of proximal and distal muscles, including neck flexors. Her daughter developed foot drop at age 4. Progressive weakness of distal limb extensor muscles and mild weakness of the neck flexor and proximal muscles were noted. In both patients, CK and nerve conductions were normal, but EMG showed a brief, small amplitude, abundant, polyphasic potential pattern. Heart and respiration were normal. Several muscle biopsies have been performed in each with various diagnoses, including aspecific myopathic changes, congenital fibre type disproportion, and denervationreinnervation. Analysis of MYH7 revealed a c.4522_4524del mutation (p.Glu1508del). This appears to be a de novo mutation, which has been reported in French, Norwegian, and Finnish patients.
Published: 2014

21. Thrombolysis in Cervical Artery Dissection - Data from the Cervical Artery Dissection and Ischaemic Stroke Patients (CADISP) database

Author: T. M. Metso, Turgut Tatlisumak, Jean Dallongeville, Yves Samson, Emmanuel Touzé, Stefan T. Engelter, Manja Kloss, V Caso, Alessandro Pezzini, Philippe Lyrer, Maria Sessa, Vincent Thijs, J.J. Martin, Elisabeth De Bustos Medeiros, C. Lamy, Stéphanie Debette, Cervical Artery Dissection, A. J. Metso, Simone Beretta, Caspar Grond-Ginsbach, Tobias Brandt, Didier Leys, and Anna Bersano
Subjects: medicine.medical_specialty, Cervical Artery, Vertebral artery dissection, medicine.medical_treatment, 030204 cardiovascular system & hematology, computer.software_genre, Revascularization, Asymptomatic, 03 medical and health sciences, 0302 clinical medicine, Modified Rankin Scale, medicine.artery, medicine, Stroke, Database, business.industry, Thrombolysis, medicine.disease, 3. Good health, Surgery, Neurology, Neurology (clinical), Internal carotid artery, medicine.symptom, business, computer, 030217 neurology & neurosurgery
Abstract: Objective: To examine whether thrombolysis for stroke attributable to cervical artery dissection (CeADStroke) affects outcome and major haemorrhage rates. Methods: We used a multicentre CeADStroke database to compare CeADStroke patients treated with and without thrombolysis. Main outcome measures were favourable 3-month outcome (modified Rankin Scale 0–2) and ‘major haemorrhage’ [any intracranial haemorrhage (ICH) and major extracranial haemorrhage]. Adjusted odds ratios [OR (95% confidence intervals)] were calculated on the whole database and on propensity-matched groups. Results: Among 616 CeADStroke patients, 68 (11.0%) received thrombolysis; which was used in 55 (81%) intravenously. Thrombolyzed patients had more severe strokes (median NIHSS score 16 vs. 3; P
Published: 2012

22. QFT Templates for Plants With a High Number of Uncertainty Parameters

Author: J.J. Martin-Romero and A. Martin-Romero
Subjects: Mathematical optimization, Template, Quantitative feedback theory, Control and Systems Engineering, Computation, Uncertain systems, Electrical and Electronic Engineering, Robust control, Parametric equation, Computer Science Applications, Analytic function, Mathematics
Abstract: When uncertainty is given in parametric form, the QFT templates computation requires time if the number of parameters is high. The latest methods do not solve the problem efficiently. The present note shows a new way to calculate templates by means of analytic functions. The discrete template is replaced by an analytic template, so operations are done with functions, not with points. In such a way, the computation time is reduced and the results can be used to solve other problems such as bounds computation
Published: 2007

23. The role of cytokines, astrocytes, microglia and apoptosis in Creutzfeldt-Jakob disease

Author: Patrick Cras, Ph. Pals, J.J. Martin, B Van Everbroeck, E Dewulf, and U. Lübke
Subjects: Lewy Body Disease, Aging, Pathology, medicine.medical_specialty, Prions, medicine.medical_treatment, Apoptosis, Cell Count, Enzyme-Linked Immunosorbent Assay, Inflammation, Creutzfeldt-Jakob Syndrome, Degenerative disease, Cerebrospinal fluid, Alzheimer Disease, mental disorders, medicine, Humans, Aged, Brain Chemistry, Neurons, Microglia, business.industry, General Neuroscience, Brain, Middle Aged, medicine.disease, Immunohistochemistry, nervous system diseases, Cytokine, medicine.anatomical_structure, nervous system, Astrocytes, Immunology, Cytokines, Neuroglia, Neurology (clinical), Geriatrics and Gerontology, Alzheimer's disease, medicine.symptom, business, Interleukin-1, Developmental Biology, Astrocyte
Abstract: In order to investigate inflammation and apoptosis in Creutzfeldt-Jakob disease (CJD) patients, we analyzed astrocytes, microglia and apoptotic neurons in brain and IL-1β in cerebrospinal fluid (CSF). Our results showed increased numbers of astrocytes in CJD and increased numbers of microglia and apoptotic neurons both in CJD and Alzheimer’s disease (AD) as compared to controls. All these markers correlated (P < 0.001) with the severity of the neuropathological lesions. An increased IL-1β concentration was found in AD and CJD CSF that correlated with the number of microglia and which did not change in the disease course of CJD. In conclusion, apoptotic neurons in CJD correlates to the neuropathological lesions and are probably related to the presence of inflammatory cells and cytokines which are present during the whole CJD disease process.
Published: 2002

24. Familial Creutzfeldt-Jakob disease in a patient carrying both a presenilin 1 missense substitution and a prion protein gene insertion

Author: B Van Everbroeck, J.J. Martin, C. Van Broeckhoven, Patrick Cras, Marc Cruts, U. Lübke, Raphael Sciot, H Backhovens, René Dom, and Bart Dermaut
Subjects: Adult, Male, Prions, animal diseases, Nonsense mutation, Mutation, Missense, Biology, Creutzfeldt-Jakob Syndrome, Presenilin, PRNP, Meninges, mental disorders, Presenilin-1, medicine, PSEN1, Humans, Missense mutation, Insertion, Brain, Membrane Proteins, medicine.disease, Virology, Pedigree, nervous system diseases, Amino Acid Substitution, Neurology, DNA Transposable Elements, Familial Creutzfeldt-Jakob, Female, Neurology (clinical), Alzheimer's disease
Abstract: We describe a patient who was clinically diagnosed with familial early-onset Alzheimer disease (AD) carrying both the E318G substitution in presenilin 1 (PSEN1) and an insertion of 7 octapeptide coding repeats in the prion protein gene (PRNP). Neuropathological examination revealed elongated cerebellar prion protein deposits in the absence of AD pathology. Further analysis of other family members showed that the Creutzfeldt-Jakob disease phenotype in this family was caused solely by the PRNP insertion. This observation is consistent with our previous finding that PSEN1 E318G is not causally related to AD.
Published: 2000

25. A Theoretical-Experimental Study on the Structure and Activity of Certain Quinolones and the Interaction of Their C<scp>u</scp>(II)-Complexes on a DNA Model

Author: Juvencio Robles, Leonardo Alvarez-Valtierra, Guillermo Mendoza-Díaz, J.J. Martin-Polo, and L. Hinojosa
Subjects: Pharmacology, Quenching (fluorescence), Intercalation (chemistry), Reactive intermediate, Stacking, Electronic structure, Toxicology, Adduct, Inorganic Chemistry, Rhodamine 6G, Crystallography, chemistry.chemical_compound, chemistry, Drug Discovery, A-DNA, Research Article
Abstract: Theoretical electronic Structure methods have been employed to study the structure and activity of certain (free) quinolones and the interaction of their Cu(II)-complexes on a DNA model (Rhodamine 6G (rhod)). As a manner of assessing the generated geometries, the nalidixic acid geometrical parameters obtained were tested against the crystallographic ones and it was found that the average error in the calculated geometries is small. The present study allows us to (1) Rationalize the observed differences in antibiotic activities through their electronic hardnesses. (2) Suggest a plausible mechanism of action for these drugs through formation of a reactive intermediate (or carrier) which would consist of a quinolone anion coordinated to an adequate metal center (Cu(II) in this study). (3) We find that, through this model of DNA (modeled with rhod) the interaction seems to be mediated by an effective π-π stacking. (4) Finally, an in vitro experiment was designed so that the intercalation process in DNA could be experimentally modeled as well. The quenching of the rhod fluorescence is proportional to the strength of the Cu(II)-complex-rhod interaction and therefore provides a quantitative measurement of the “intercalating” capacity of the quinolones and their copper complexes. These results agree well with the theoretical total adduct formation energies.
Published: 2000

26. Antigen Retrieval in Prion Protein Immunohistochemistry

Author: B Van Everbroeck, J.J. Martin, Patrick Cras, and Ph. Pals
Subjects: 0301 basic medicine, Pathology, medicine.medical_specialty, Hot Temperature, Histology, Formates, Prions, Formic acid, Encephalopathy, Picric acid, Creutzfeldt-Jakob Syndrome, Epitope, Epitopes, 03 medical and health sciences, chemistry.chemical_compound, Picrates, Antigen, Reference Values, medicine, Humans, Microwaves, 030102 biochemistry & molecular biology, Histological Techniques, Brain, medicine.disease, Immunohistochemistry, Molecular biology, 030104 developmental biology, Antigen retrieval, chemistry, Indicators and Reagents, Anatomy, Immunostaining
Abstract: SUMMARY Transmissible spongiform encephalopathies are a group of neurodegenerative diseases occurring in both humans and animals and are most likely caused by prions. Neuropathological confirmation of the clinical diagnosis has been a problem because of the difficulty in epitope retrieval from formalin-fixed, paraffin-embedded brain specimens. Many different protocols for the detection of prions in brain tissue have been used. Thus far, picric and/or formic acid, steam autoclaving at 121C of sections, microwave treatment, and 4 M guanidine thiocyanate treatment have been suggested. The objective of our experiment was to obtain the standard pretreatment(s) resulting in optimal immunostaining. In the experiment, successive tissue slides of brain specimens of several Creutzfeldt‐Jakob disease and control patients were stained using different combinations of pretreatments. Using densitometric analysis, several well-defined locations per section were examined and prion immunostaining was quantified. The results showed that autoclaving is necessary for antigen retrieval and cannot be substituted by microwave treatment. The best results were obtained when the following combination was used in the specified order: 15 min saturated picric acid, 10 min steam autoclaving at 121C, 5 min 88% formic acid, and 2 hr 4 M guanidine thiocyanate at 4C. (J Histochem Cytochem 47:1465‐1470, 1999)
Published: 1999

27. A new combined Bodian-Luxol technique for staining unmyelinated axons in semithin, resin-embedded peripheral nerves: a comparison with electron microscopy

Author: Arnaud Fumal, Manuel Deprez, J.J. Martin, Michel Reznik, and Chantal Ceuterick-de Groote
Subjects: Male, Nervous system, Silver Staining, Pathology, medicine.medical_specialty, Indoles, Unmyelinated nerve fiber, Population, Axonal loss, Cell Count, Biology, Nerve Fibers, Myelinated, Pathology and Forensic Medicine, law.invention, Cellular and Molecular Neuroscience, Nerve Fibers, law, medicine, Humans, Peripheral Nerves, Axon, Coloring Agents, education, Skin, education.field_of_study, Tissue Embedding, Anatomy, Middle Aged, Axons, Staining, Microscopy, Electron, medicine.anatomical_structure, Ultrastructure, Neurology (clinical), Electron microscope, Resins, Plant
Abstract: Quantitation of unmyelinated fibers (UF) in peripheral nerves has classically relied upon ultrastructural morphometry. Because this method is time-consuming, it is not typically performed in routine analysis of nerve biopsies. We applied the Bodian-Luxol technique to detect unmyelinated axons by light microscopy on semithin sections from resin-embedded nerve tissue. Estimates were compared to ultrastructural counts. The staining appeared highly specific for axons. Excellent correlation was found between optic densities and the population of UF larger than 0.5 microm. The smallest profiles detected by light microscopy had a diameter close to 0.6 microm. This new technique is not a substitute for ultrastructural quantitative morphometry of UF, as very small unmyelinated axons, especially regenerating ones, can not be reliably visualized. However, it provides a valuable light microscopic method for evaluating axonal loss among UF.
Published: 1999

28. Mutation analysis of the nerve specific promoter of the peripheral myelin protein 22 gene in CMT1 disease and HNPP

Author: C. Van Broeckhoven, P. De Jonghe, J.J. Martin, E. De Vriendt, Pragna Patel, and Eva Nelis
Subjects: Male, DNA Mutational Analysis, Molecular Sequence Data, Biology, Polymerase Chain Reaction, Myelin, Exon, Charcot-Marie-Tooth Disease, Peripheral myelin protein 22, Gene duplication, Genetics, medicine, Humans, Coding region, Promoter Regions, Genetic, Gene, Polymorphism, Single-Stranded Conformational, Genetics (clinical), DNA Primers, Base Sequence, Exons, medicine.disease, Pedigree, medicine.anatomical_structure, Peripheral neuropathy, Mutation, Mutation testing, Female, Hereditary Sensory and Motor Neuropathy, Myelin Proteins, Research Article
Abstract: We analysed the nerve specific promoter of the peripheral myelin protein 22 gene (PMP22) in a set of 15 unrelated patients with Charcot-Marie-Tooth type 1 disease (CMT1) and 16 unrelated patients with hereditary neuropathy with liability to pressure palsies (HNPP). In these patients no duplication/deletion nor a mutation in the coding region of the CMT1/ HNPP genes was detected. In one autosomal dominant CMT1 patient, we identified a base change in the non-coding exon 1A of PMP22 which, however, did not cosegregate with the disease in the family. This study indicates that mutations in the nerve specific PMP22 promoter and 5' untranslated exon will not be a common genetic cause of CMT1A and HNPP.
Published: 1998

29. Neuro-ophthalmological aspects of prion diseases

Author: A. Neetens and J.J. Martin
Subjects: Fatal familial insomnia, Pathology, medicine.medical_specialty, medicine.diagnostic_test, business.industry, animal diseases, Bovine spongiform encephalopathy, Brain biopsy, Scrapie, Disease, Grey matter, medicine.disease, nervous system diseases, Ophthalmology, medicine.anatomical_structure, mental disorders, Immunology, Kuru, Medicine, Neurology (clinical), business, Spongiosis
Abstract: Prion brain diseases (Kuru, Creutzfeldt-Jakob disease, familial fatal insomnia (FFI), Gerstman-Straussler-Scheinker syndrome) are conditioned by the host’s genome. Susceptibility (hereditary) is related to the PrPc gene polymorphism (insertion and/or point mutations at different codons). The normal harmless PrPc (neuron) is transformed into a rogue structurally altered PrPsc (scrapie) invading neurocells. Human consumption of protein from bovine spongiform encephalopathy (BSE) cattle, fed scrapie-sheep offal, may be responsible for prion disease. The clinical features are mirrored by a wide spectrum of brain grey matter involvement in middle-aged patients. Progressive dementia and supranuclear (ocular) motor symptoms are characteristic; at onset visual symptoms may occur in 20–25% of cases. In dementing patients, diagnosis of prion disease may only be confirmed by brain biopsy, demonstrating the typical spongiosis and pleated prion plaques (methacarn fixation). Care should be taken to never use tissue fro...
Published: 1998

30. Pathological complete remission with preoperative hyperfractionated chemoradiation v/s standard chemoradiation

Author: C. Borque Molinos, J.J. Martin Ortega, C. Fuentes Sanchez, A.N.A. Armijo Mallorquín, M. García Morales, M. Espineira Yanes, J. Pena Vivas, S. Villamil Montufar, J. C. Martínez Cedres, and R. Hernandez Gonzalez
Subjects: medicine.medical_specialty, Cancer Research, Oncology, business.industry, Radiology Nuclear Medicine and imaging, Medicine, Pathological Complete Remission, Radiology, Nuclear Medicine and imaging, Radiology, business
Published: 2013
Full Text: View/download PDF

31. Tuberculous meningitis in immunocompetent adults: two cases with a clinico-radiological discussion

Author: I. De Volder, L. Truyen, J.W.M. Van Goethem, A. Vercruyssen, and J.J. Martin
Subjects: Adult, Male, medicine.medical_specialty, Pediatrics, Tuberculosis, Tuberculous meningitis, Diagnosis, Differential, Mycobacterium tuberculosis, Central nervous system disease, Meninges, medicine, Humans, Neuroradiology, Neurologic Examination, biology, business.industry, Incidence (epidemiology), Brain, General Medicine, Middle Aged, medicine.disease, biology.organism_classification, Magnetic Resonance Imaging, Surgery, Tuberculosis, Meningeal, Radiological weapon, Neurology (clinical), Tomography, X-Ray Computed, business, Immunocompetence, Meningitis
Abstract: In developed countries with a low incidence of tuberculosis, infection with Mycobacterium tuberculosis is easily overlooked as the cause of meningitis in an immunocompetent adult. Two cases are presented, with emphasis on the main reasons for delay of diagnosis. Neuroradiology revealed a progressive hypertrophic basal meningitis. The clinical and radiological outcome was good after tuberculostatic and corticosteroid treatment.
Published: 1996

32. Molecular structure and spectroscopy of aqua-91,10-phenanthroline) (L-methioninato-N,O) copper(II) nitrate monohydrate

Author: Willem L. Driessen, J.J. Martin-Polo, Guillermo Mendoza-Díaz, and Francisco Cervantes-Lee
Subjects: Inorganic Chemistry, chemistry.chemical_compound, Crystallography, chemistry, Phenanthroline, Copper(II) nitrate, Stacking, Carboxylate, Chromophore, Biochemistry, Single crystal, Square pyramidal molecular geometry, Monoclinic crystal system
Abstract: The crystal and molecular structure of aqua(1,10-phenanthroline)(methioninato-N,O)-copper(II) nitrate monohydrate, [Cu(phen)(met)(H2O)]NO3·H2O, has been determined by single crystal X-ray diffraction. In the mixed complex, the methionine act as bidentate ligand with the amino and carboxylate groups as donors. The geometry around the copper ion is square pyramidal, the axial position being occupied by a water molecule. The asymmetric units are hydrogen bonded to their neighbors, forming a polymeric hydrogen-bonded lattice. Stacking interactions between the phenanthroline rings from the different asymmetric units is observed. The strength of the stacking interaction is dependent on the amino acid coordinated. Visible absorption spectra and epr of frozen solution suggest that the structure is similar to that of analogous complexes in aqueous solution, with a CuN3O3 chromophore, where two of the coordinated oxygens are from two waters axially coordinated. Main crystal data: C17H22CuN4O7S, monoclinic, P21, a = 12.026(2), b = 6.8680(10), c = 13.355(3), β = 113.58(3), Vol. = 1010.9 A−3, Z = 2, formula weight = 490.0.
Published: 1995

33. Patient homozygous for a recessive POLG mutation presents with features of MERRF

Author: R. Mercelis, Sara Seneca, Ann Löfgren, J.J. Martin, Chantal Ceuterick, C. Van Broeckhoven, G. Van Goethem, and Department of Embryology and Genetics
Subjects: Male, Myoclonus, Ataxia, Adolescent, DNA Mutational Analysis, Genes, Recessive, ragged red fibers (RRF), DNA-Directed DNA Polymerase, Biology, medicine.disease_cause, DNA, Mitochondrial, Epilepsy, Seizures, medicine, Humans, Missense mutation, Allele, Muscle, Skeletal, Alleles, Genetics, Mutation, External ophthalmoplegia, Homozygote, MERRF syndrome, DNA, medicine.disease, progressive external ophthalmoplegia, MERRF Syndrome, eye diseases, DNA Polymerase gamma, Haplotypes, POLG, PEO, Neurology (clinical), medicine.symptom
Abstract: Both dominant and recessive missense mutations were recently reported in the gene encoding the mitochondrial DNA polymerase gamma (POLG) in patients with progressive external ophthalmoplegia (PEO). The authors report on a patient homozygous for a recessive missense mutation in POLG who presented with a multisystem disorder without PEO. The most prominent features were myoclonus, seizure, and sensory ataxic neuropathy, so the clinical picture overlapped with the syndrome of myoclonus, epilepsy, and ragged red fibers (MERRF).
Published: 2003

34. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain

Author: H. Hattig, C. Delli Pizzi, M. C. Addonizio, Michelle Davis, A. R. Giovagnoli, L. Florensa, M. Roth, J. de Kruijk, Francisco Lacruz, Ph. Dewailly, A. Toygar, C. Avendano, P.P. De Deyn, J. F. Hurtevent, F. Lomeila, T. W. Wong, Gordon T. Plant, M. Bud, H. J. Willison, DH Miller, D. W. Langdon, R. Cioni, J. Servan, A. Kaygisiz, E. Racadot, D. B. Schens, E. Picciola, L. Falip, C. Bouchard, J. Jotova, A. Jorge-Santamaria, P. Misra, A. Dufour, C. P. Panagopoulos, A. Venneri, B. Sredni, B. Angelard, M. Janelidze, M. Carreno, J. Obenberger, J. Pouget, H. W. Moser, R. Kaufmann, J. A. Molina, D. Linden, A. Martin Urda, E. Uvestad, A. Krone, J. P. Cochin, J. Mallecourt, A. Cambon-Thomsen, K. Violleau, P. Osschmann, A. M. Durocher, E. Bussaglia, D. M. Danielle, H. Efendi, C. Van Broeckhoven, K. G. Jordan, W. Rautenberg, C. Iniguez, J. M. Delgado, Graham Watson, M. Lawden, Gareth J. Barker, K. Stiasny, James T. Becker, G. Campanella, E. Peghi, A. Poli, A. Haddad, T. Yamawaki, Giacomo P. Comi, S. Sotgiu, B. Ersmark, A. Pomes, M. Ziegler, P. Ferrante, P. Ruppi, H. KuÇukoglu, R. Bouton, U. K. Rinne, P. Vieregge, M. Dary, P. Giunti, Peter J. Goadsby, S. Jung, E. Secor, A. Steinberg, N. Vila, M. A. Hernandez, M. Cursi, A. Enqelhardt, A. Engelhardt, J. Veitch, F. Di Silverio, F. Arnaud, B. Neundörfer, R. Brucher, Dominique Caparros-Lefebvre, B. Meyer, Marianne Dieterich, M. H. Snidaro, R. Gomez, R. Cerbo, M. Ragno, J. M. Vance, S. Nemni, A. Caliskan, F. Barros, I. Velcheva, D. Ceballos-Baumann, V. Barak, A. Avila, N. Antonova, F. Resche, S. Pappata, L. Varela, S. R. Silveira Santos, A. Cammarota, L. Naccache, Y. Nara, E. Tournier-Lasserves, R. Mobner, T. Chase, A. Ensenyat, J. Ulrich, G. Giegerich, M. Rother, M. Revilla, N. Nitschke, K. Honczarenko, E. Basart Tarrats, J. Blin, B. Jacob, J. Santamaria, S. Knezevic, J. L. Castillo, M. Antem, J. Colomer, O. Busse, Didier Hannequin, S. Carrier, J. B. Ruidavets, C. Rozman, J. Bogoussslavsky, J. Pascual Calvet, E. Monros, J. M. Polo, M. Zucconl, Javier Muruzabal, R. R. Allen, R. Rivolta, K. Haugaard, A. Nespolo, K. Hoang-Xuang, G. Bussone, T. Avramidis, E. Corsini, Christiana Franke, T. Vinogradova, H. Boot, K. Vestergaard, G. H. Jansen, N. Argentino, M. Raltzig, W. Linssen, Mark B. Pepys, P. Roblot, L. Lauritzen, E. Fainardi, D. Morin, T. X. Arbizu Urdiain, J. Wollenhaupt, S. Bostantjopoulou, G. Pavesi, A. D. Forman, Giovanni Fabbrini, D. Jean, J. J. Archelos, M. I. Blanchs, M. Del Gobbo, Anna Carla Turconi, Ch. Derouesné, Elio Scarpini, A. Visbeck, P. Castejon, J. P. Renou, F. Mounier-Vehier, G. Potagas, Ch. Duyckaerts, A. Filla, R. Schneider, G. Ronen, K. Nagata, J. P. Vedel, A. Henneberg, G. van Melle, C. Baratti, H. Knott, M. C. Prevett, A. Bes, B. Metin, Jos V. Reempts, L. Martorell, Mefkure Eraksoy, H. O. Handwerker, D. S. Younger, O. Oktem, D. Frongillo, C. Soriano-Soriano, L. Niehaus, F. Zipp, A. Tartaro, S Newman, R. H. Browne, P. Davous, R. Sanchez, M. Muros, M. E. Kornhuber, A. Lavarone, M. Mohr, M. R. Garcia, S. Russell, H. Kellar-Wood, M. R. Tola, B. Ostermeyer, Ch. Tzekov, K. Sartor, E. B. Ringelstein, P. P. Gazzaniga, Paul Krack, H. Fidaner, H. Rico, T. Dbaiss, F. Alameda, E. Torchiana, L. Rumbach, I. Charques, J. M. Bogaard, C. D. Frith, L. J. Rappelle, R. Brenner, A. Joutel, K. Fuxe, G. HÄcker, M. J. Blaser, J. Valls-SolÇ, G. Ulm, M. Alberdi, A. Bock, F. W. Bertelsmann, U. Wieshmann, J. Visa, J. R. Lupski, D. D'Amico, L. M. P. Ramos, A. A. Vanderbark, R. Horn, M. Warmuth, Dietmar Kühne, Mark S. Palmer, C. Ehrenheim, E. Canga, S. Viola, O. Scarpino, P. Naldi, R. Almeida, A. A. Raymond, J. Gamez, Stephan Arnold, A. DiGiovanni, J. Dalmau, C. C. Chari, H. F. Beer, J. C. Koetsier, J. Iriarte, E. Yunis, J. Casadevall, E. Le Guern, E. Stenager, S. R. Benbadis, J. M. Warter, F. Burklin, I. Theodorou, L. Johannesen, G. A. Graveland, X. Leclerc, I. Vecchio, L. Ozelius, G. Nicoletti, R. K. Gherardi, E. Esperet, M. L. Delodovici, F. Cattin, F. Paiau, Giorgio Sacilotto, C. A. J. Broere, D. Chavdarov, J. P. Willmer, C. H. Hawkes, Th. Naegele, E. Ellie, E. Dartigues, M. J. Guardiola, S. Hesse, Z. Levic, Marco Rovaris, P. Saugeir-Veber, B. A. Yaqub, H. F. Durwen, R. Larumbe, J. Ballabrina, M. Sendtner, J. Röther, M. Horstink, C. Kluglein, M.P. Montesi, H. Apaydin, J. Montoya, E. Waubant, Ch. Verellen-Dunoulin, A. Nicolai, J. Lopez-Delval, R. Lemon, G. Cantinho, E. Granieri, A. Zeviani, Wolfgang H. Oertel, U. Ficola, V. Di Piero, V. Fragola, K. Sabev, M. V. Guitera, I. Turki, F. Bolgert, P. Ingrand, J. M. Gobernado, L. M. E. Grimaldi, S. Baybas, B. Eymard, Y. Rolland, Y. Robitaille, Ta. Pampols, P. J. Koehler, A. Carroacedo, J. Vilchez, S. Di Vittorio, I. R. Rise, T. Nagy, M. Kuffner, E. Palazzini, A. Ott, J. Pruim, T. X. Arbizu, E. Manetti, C. Cervera, S. Felber, G. Gursoy, J. Scholz, G. A. Buscaino, M. S. Chen, A. Pascual, J. Hazan, J. U. Gajda, J. G. Cea, G. Bottini, G. Damalik, F. Le Doze, G. Bonaldi, J. M. Hew, C. Messina, A. M. Kennedy, J. M. Carney, N. M. F. Murray, M. Parent, M. Koepp, V. Dimova, D. De Leo, K. Jellinger, G. Salemi, S. Mientus, M. L. Hansen, F. Mazzucchelli, J. Vieth, M. Mauri, E. Bartels, L. Johannsen, C. Humphreys, J. Emile, D. N. Landon, E. Kansu, R. Sanchez-Pernaute, Rsj Frackowiak, M. Gonzalez Torres, L. Oller, C. Machedo, J. Kother, M. Billiard, H. Durak, T. Schindler, A. Frank, A. Uncini, A. Sbriccoli, C. Farinas, D. W. Paty, N. Fast, A. T. Zangaladze, A. Kerkhofs, J. M. Pino Garcia, I. De la Fuente, B. Marini, L. Gomez, I. Rubio, Alessandra Bardoni, C. Brodie, P. Acin, U. Sliwka, S. A. Hawkins, S. Tardieu, F. Vitullo, J. M. Pereira Monteino, R. Gagliardi, T. Jezewski, A. Cano, T. Lempert, F. Abad Alegria, G. Rotondo, D. Ince, C. Martinez Parra, Y. Huang, H. Luders, Y. Steinvil, F. G. A. Van Der Meche, R. Bianchi, A. Sanchez, T. Sevilla, J. M. Ketelslegers, A. Domzal-Stryga, M. Pandolfo, M. O. Josse, K. W. Neff, I. Blanco, G. W. Bruyn, O. W. Witte, J. L. Thibault, G. Andersen, J. Pariset, A. Marcone, R. J. M. Lane, A. Hofman, M. Verin, T. Matilla, P. Bedoucha, J. Roche, M. Lai, M. Collard, A. Ugarte, F. Gallecho, D. Silbersweig, C. Kennard, J. P. Azulay, T. W. Ho, P. L. I. Dellemijn, R. Girardello, F. Baas, B. Voss, F. Rozenberg, E. M. Brocker, V. Stanev, A. A. J. Soeterboek, A. Marra, A. Rey, E. Ertem, M. Sawradewicz-Rybak, J. De Keyser, P. Cavallari, F. Proust, Y. Chevalier, H. C. Hansen, D. Leys, C. A. Davie, K. Hoang-Xuan, C. Bairati, H. van Crevel, Thomas T. Warner, B. Bompais, A. Dobbeleir, T Campbell, C. Macko, C. J. M. Klijn, M. Dussallant, T. P. Berlit, W. Rozenbaum, M. J. van den Bent, W. A. Rocca, M. Muller, H. Hundemer, U. Zifko, M. Campera, F. Drislane, D. Ranoux, T. M. Kloss, Anil Kumar, I. Ruolt, C. Bargnani, B. Marescau, N. A. Losseff, S. Notermans, B. Kint, E. T. Burke, C. Aykut, J. Matias Guiu, P. Maquet, T. Drogendijk, M. Leone, K. von Ammon, M. Pepeliarska, C. Prados, L. DiGiamberardino, T. Logtenberg, G. Lenoir, I. Castaldo, Damhaut, M. Radionova, G. Sirabian, R. Navon, Giovanni Antonini, K. Al Moutaery, E. Chamas, R. Schönhuber, M. Giannini, B. Debilly, I. Labatut, H. Henon, J. A. Egido, M. Baudrimont, J. N. Lorenzo, J. E. C. Bromberg, R. Antonacci, J. J. Vilchez, T. Moulin, B. Rautenstrauss, Giovanni Meola, J. Noth, S Mammi, P. Laforet, F. Lopez, C. Gehring, S. Bort, G. Rancurel, D. Decamps, S. Kostadinova, Y. Shapira, B. Neundoerfer, D. Chavrot, M. Solimena, J. P. Salier, W. Deberdt, R. Hoff-Jörgensen, A. Messina, S. Meairs, G. Rosoklija, E. Nelis, I. Bertran, C. Ertekin, J. Lohmeyer, Mitermayer Galvao dos Reis, L. Calo, E. Maccagnano, A. P. Hays, J. Verlooy, M. G. Forno, T. Blanco, L. Bail, Gabriella Silvestri, J. Montero, F. Bertrand, R. T. Ghnassia, C. Besses, T. Sereghy, F. Shalit, G. Bogliun, S. Braghi, St. Baykouchev, C. Franke, A. Lasa, L. C. Archard, J. Kriebel, S. Shaunak, M. Nocito, Alexander Tsiskaridze, E. Manfredini, T. Seigal, David G. Gadian, M. Barlas, J. D. Degos, C. Seeber, J. Caemert, J. L. Mas, R. B. Pepinsky, M. G. D'Angelo, N. Baumann, S. Yorifuji, H. P. Endtz, M. A. Cassatella, R. A. C. Hughes, V. Golzi, A. Bittencourt, A. Ferreira, M. Sanson, C. Alper, M. Vermeulen, M. A. A. van Walderveen, E. Alexiou, C. H. Lucas, M. Fiorelli, Y. N. Debbink, R. Gil, S. Congia, T. Banerjee, J. M. Bouchard, A. N. Pinto, A. Ceballos-Baumann, G. Grollier, P. I. M. Schmitz, M. D. Catata, N. Lahat, N. S. Rao, P. Papathanasopoulos, J. Valls-Solé, D. Claus, G. Schroter, A. Castro, C. Videbaek, R. Martinez Dreke, A. D. Platts, M. Hermesl, A. C. PeÇanha-Martins, M. Cardoso Silva, P. Masnou, M. J. A. Tanner, Ch. Confavreux, B. Mishu, H. Rasmussen, L. Valenciano, Carlo Pozzilli, S. W. Li, V. Salzman, Y. Vashtang, Massimo Franceschi, M. Severo, G. Deuschl, S. Setien, G. Mariani, A. Protti, J. Castillo, M. J. B. Taphoorn, M. Frontali, I. Milonas, D. Decoq, J. A. Navarro, S. Castellvi-Pel, C. Ertikin, M. Urtasun, Y. Lajat, B. E. Kendall, E. Verdu, B. Gueguen, E. Boisen, R. Couderc, A Danek, JM Stevens, F. Nicoli, L. Feltri, M. L. Vazquez-Andre, J. A. Morgan-Hughes, L. D'Angelo, F. Y. Liew, L. F. Pascual, J. Patrignani Ochoa, Vittorio Martinelli, J. Cophignon, L. Zhang, S. Martin, J. F. Meder, H. C. Buschmann, L. Bertin, J. van Gijn, A. Barreiro, A. Cools, C. Leon, A. Berod, E. A. Anllo, E. Zanette, L. Petrov, R. Barona, B. Gallicchio, P. J. Cozzone, N. Diederich, G. Cancel, L. Schelosky, P. Orizaola, K. Yulug, S. Ozer, Valeria A. Sansone, B. Guiraud-Chaumeil, K. Voigt, P. Labauge, M. Eoli, J. Zhu, J. Aguirre, M. Ferrarini, B. Zyluk, E. Planas, A. Cadilha, C. Tortorella, H. Bismuth, C. E. Counsell, A. Laun, A. Ferlini, Rio J. Montalban, N. Biary, L. Becker, M. Fardeau, M. Poloni, V. M. S. de Bruin, C. Fornada, J. Barros, E. Ganzmann, E. Touze, D. Wallach, J. Peila, H. Fujimura, M. T. Iba-Zizen, G. Macchi, C. Villoslada, R. Gouider, Ph. Rondepierre, P. Grummich, P. Chiodi, C. Conte, M. Michels, P. Annunziata, G. Semana, C. Sommer, J. Vajsar, D. Zekin, J. Kulisevsky, David G. Munoz, B. Jacotot, M. Magoni, A. Luxen, T. Garcia-Silva, S. Di Cesare, Christophe Tzourio, M. Gomori, I. Picomell, L. Santoro, F. Villa, Giovanni Pennisi, T. Ribalta, J. M. Molto, L. Marzorati, P. Loiseau, F. Gemignani, A. Gironell, J. Wissel, A. Prusinski, F. Cailloux, P. Villanueva-Hemandez, P. Cozzone, T. Del Ser, J. Sans-Sabrafen, M. Zappia, P. W. A. Willems, G. Tchernia, D. Gardeur, R. Bauer, F. Palomo, H. Metz, S. Lamoureux, C. Chastang, I. Reinhard, A. Goldfarb, S. Harder, Jordi Río, C. Ozkara, E. Tekinsoy, P. Vontobell, J. De Recondo, M. Rabasa, L. Lacomblez, F. Boon, Dgt Thomas, V. Palma, Renato Mantegazza, A. Dervis, M. Nueckel, B. YalÇinerner, I. Duran, G. Dalla Volta, A. Zubimendi, J. Pinheiro, A. Marbini, Xavier Montalban, H. Wekerle, X. Pereira Monteino, F. Crespo, F. Koskas, N. Battistini, C. Ruiz, H. Offner, J. de Pommery, P. Kanovsky, J. Y. Barnett, J. Pardo, G. Tomei, R. Rene, H. M. Lokhorst, P. Thajeb, H. Bilgin, D. McGehee, R. Fahsold, L. Morgante, Katie Sidle, C. Delwaide, M. N. Diaye, P. H. Rice, A. Creange, C. Sabev, K. Stephan, K. WeilBenborn, G. Magnani, L. Grymonprez, F. Cardellach, M. Kaps, N. G. Meco, F. Vega, V. Bonifati, A. Desomer, M. Baldy-Moulinier, G. Kvale, F. J. Authier, B. Yegen, T. Ho, J. M. Rozet, E. A. Cabanis, L. Bruce, L. Ambrosoli, M. A. Petrella, M. Hernandez, P. Timmings, H. B. van der Worp, F. Mahieux, A. Urbano-Marquez, D. A. Krendel, A. A. Garcia, R. Divari, R. Michalowicz, M. R. Piedmonte, M. Bondavalli, M. Zanca, P. F. Ippel, Onofre Combarros, B. Tavitian, E. Hirsch, I. Anastasopoulos, A. Roses, A. Köhler, P. Vienna, V. Timmerman, P. Sergi, F. Cornelio, A. Di Pasquale, R. Verleger, S. Castellvirel, J. Proano, B. van Moll, F. Rubio, W. Hacke, I. Lavenu, L. Zetta, M. W. Tas, N. Bittmann, M. Bonamini, O. R. Hommes, V. Dousset, N. Afsar, S. Belal, R. R. Myers, J. Goes, Giuseppe Vita, E. Clementi, V. G. Karepov, M. Jueptner, A Vincent, P. Emmrich, Th. Heb, A. Caballo, J. Gallego, T. Mokrusch, C. Perla, L. Gebuhrer, O. Titlbach, Alessandro Prelle, A. Czlonkowska, M. Russo, D. Hadjiev, T. S. Chkhikvishvili, M. Oehlschlager, G. Becker, I. Günther, E. N. Stenager, J. Garcia Agundez, J. Casademont, J. Batlle, S. Podobnik-Sarkanji, C. Alonso-Villaverde, B. Delaguillaume, B. Genc, B. Mazoyer, A. Rodriguez-Al-barino, Ch. Hilger, B. Ferrero, R. Price, W. Grisold, L. Fuhry, D. Oulbani, D. Ewing, A. Petkov, W. Walther, A. Gokyigit, John Newsom-Davis, J. Tayot, D. Seliak, G. Pelliccioni, D. Campagne, K. Kessler, F. Boureau, D. Perani, J. P. N'Guyen, N. Tchalucova, B. A. Antin-Ozerkis, C. Lacroix, B. D. Aronovich, I. H. Jenkins, E. A. dos Reis, M. Hortells, H. M. Meinck, H. Ch. Buschmann, S. C. J. M. Jacobs, T. Wetter, P. Creissard, N. Martinez, J. Weidenfeldl, H. J. Sturenburg, G. Damlacik, V. Gracia, J. C. Turpin, A. Pou-Serradell, J. P. Vincent, T. Gagoshidze, U. Ozkutlu, M. McLeod, K. Siegfried, I. Tchaoussoglou, J. Hildebrand, S. Kowalska, M. C. Picot, G. Galardin, L. Crevits, F. Andreetta, S. Larumbe-Lobalde, G. de la Sierra, J. C. Alvarez-Cermeno, R. J. Seitz, P. L. Oey, L. Ptacek, A. M. J. Paans, A. Wirrwar, A. Schmied, J. Uilchez, H. Tounsi, D. Hipola, V. Avoledo, Y. Hirata, P. Vermersch, T. M. Aisonobe, J. Valls-SoIè, H. Staunton, J. Dichgans, R. Karabudak, I. Dones, G. Porta, E. Janssens, Maria Martinez, J. M. Fernandez-Real, R. Villagra, Y. Yoshino, C. Kabus, K. Schimrigk, I. Girard-Buttaz, F. Piccoli, F. Aichner, P. Zuchegna, S. M. Al Deeb, F. Bono, N. Busquets, A. Jobert, Patrizia Ciscato, M. Martin, L. Polman, S. Darbra, V. Le Cam-Duchez, F. Baldissera, B. Baykan-Kurt, D. Guez, M. Bratoeva, H. Matsui, M. Mila, H. Perron, L. Bjorge, G. Husby, Steven T. DeKosky, D. R. Cornblath, J. M. Gabriel, J. J. Poza, Y. Wu, A. Toscano, R. P. Kleyweg, J. Kuhnen, S. O. Confort-Gouny, A. Barcelo, A. M. Conti, C. Fiol, C. Steichen-Wiehn, J. Rodes, M. Cavenaile, C. Vedeler, M. Drlicek, C. Argentino, M. L. Peris, A. Cervello, A. Z. GinaÏ, S. Yancheva, D. Passingham, S. Aoba, D. L. Lopez, T. Rechlin, K. Sonka, L. Grazzi, V. Folnegovic-Smalc, Maurizio Moggio, S. Rivaud, F. G. I. Jennekens, C. H. Hartard, H. Meierkord, G. Stocklin, M. D. Catala, W. C. McKay, E. Salmon, C. Navarro, I. Pastor, L. Canafoglia, M. De Braekeleer, P. K. Thomas, C. Mocellini, C. Pierre-Jerome, M. C. Dalakas, P. Pollak, M. Levivier, Niall Quinn, G. E. Rivolta, Z. Tunca, H. Zeumer, J. Garcia Tena, St. Guily, P. Gaudray, Johannes Kornhuber, V. Petrunjashev, R. Montesanti, R. J. Abbott, H. Petit, G. Kiteva-Trencevska, F. Carletto, C. Ramo, I. M. Pino, P. Beau, G. F. Mennuni, F. Moschian, F. Meneghini, B. Zdziarska, B. Fontaine, C. Stephens, G. Meco, K. Reiners, G. Badlan, M. Sessa, I. Degaey, S. M. Hassan, C. Albani, F. Caroeller, M. Schroeder, G. Savettieri, A. Novelletto, R. Kurita, P. Oschmann, I. Plaza, M. Oliveres, Simone Spuler, A. Molins, M. Schwab, J. R. Kalden, C. P. Gennaula, Y. Baklan, O. Picard, J. M. Léger, B. Mokri, E. Ghidoni, M. Jacob, D. Deplanque, W. JÄnisch, C. De Andres, P. De Deyn, G. Guomundsson, B. Herron, J. Barado, J. L. Gastaut, Guglielmo Scarlato, F. Poron, Nicola Jones, H. Teisserenc, C. P. Hawkins, A. J. Steck, H. C. Chandler, S. Blanc, J. H. Faiss, Jm. Soler Insa, I. Sarova-Ponchas, M. Malberin, A. Sackmann, G. De Vuono, K. Kaiser-Rub, K. Badhia, E. Szwabowska-Orzeszko, S. Ramm, C. Jodice, G. Franck, J. Marta-Moreno, R. Sciolla, C. Fritz, A. Attaccalite, F. Weber, E. Neuman, M. Cannata, A. Rodriguez, I. Nachainkin, R. Raffaele, T. S. Yu, N. Losseff, E. Fabrizio, C. Khati, M. Keipes, M. P. Ortega, M. Ramos-Alvarez, E. Brambilla, A. Tarasov, K. H. Wollinsky, O. B. Paulson, F. Boller, G. Bozzato, H. Wagnur, R. Canton, D. Testa, E. Kutluaye, M. Calopa, D. Smadja, G. Malatesta, F. Baggi, A. Stracciari, G. Daral, G. Avanzini, J. Perret, J. Arenas, P. Boon, I. Gomes, A. Vortmeyer, P. Cesaro, S. Venz, E. Bernd Ringelstein, N. Milani, D. Laplane, P. Seibel, E. Tournier-Lasserve, Alexis Brice, L. Motti, E. Wascher, R. J. Abbot, F. Miralles, A. Turon, P. De Camilli, G. Luz, G. C. Guazzi, S. Tekin, F. Lesoin, T. Kryst, N. Lannoy, F. Gerstenbrand, S. Ballivet, H. A. M. van Diemen, J. Lopez-ArLandis, P. Bell, A. Silvani, M. A. Garcia, S. Vorstrup, D. Langdon, S. Ueno, B. Sander, V. Ozurk, C. Gurses, P. Berlit, J. M. Martinez-Lage, M. Treacy, S. O. Rodiek, S. Cherninkova, J. Grimaud, P. Marozzi, K. Hasert, S. Goldman, S. H. Ingwersen, A. Taghavy, T. Roig, R. Harper, I. Sarova-Pinchas, Anthony H.V. Schapira, R. Lebtahi, A. Vidaller, B. Stankov, D. Link, J. p. Malin, V. Petrova, Ludwig Kappos, J. L. Ochoa, T. Torbergsen, M. Carpo, M. Donato, Simon Shorvon, J. Mieszkowski, J. Perez-Serra, Raymond Voltz, G. Comi, S. Rafique, A. Perez-Sempere, N. Khalfallah, S. Bailleul, M. Borgers, S. Banfi, S. Mossman, A. Laihinen, G. Filippini, R. A. Grunewald, E. Stern, H. D. Herrmann, A. G. Droogan, P. Xue, A. Grilo, L. La Mantia, J. H. J. Wokke, S. Pizzul, Kie Kian Ang, S. Rapaport, W. Szaplyko, B. Romero, P. Brunet, A. Albanese, C. Davie, V. Crespi, F. Birklein, H. Sharif, L. Jose, D. Auer, N. Heye, Martin N. Rossor, C. E. Henderson, M. J. Koepp, J. Rubio, P. L. Baron, S. Mahal, Juha O. Rinne, J. I. Emparanza, S. E. C. Davies, Frederik Barkhof, M. Riva, R. E. Brenner, B. A. Pope, Lemaire, E. Dupont, D. Ulbricht, G. C. Pastorino, R. Retska, E. Chroni, A. Danielli, V. Malashkhia, T. Canet, J. C. Garcia-Valdecasas, J. Serena, R. A. Pfeiffer, B. Wirk, B. Muzzetto, V. Caruso, M. L. Giros, A. Ming Wang, E. L. E. Guern, F. Bille-Turg, Y. Satoh, C. H. Franke, M. Ait-Kaci-Ahmed, D. Genis, T. Pasierski, D. Riva, M. Panisset, A. Chamorro, P.A. van Doorn, S. Schellong, H. Hamer, F. Durif, P. Krauseneck, Y. Bahou, B. A. Pickut, M. Rijnites, H. Nyland, G. Jager, L. L. Serra, A. Rohl, X. P. Li, O. Arena, Hubert Kwieciński, N. Milpied, M. C. Bourdel, S. Assami, L. Law, J. Moszkowski, J. W. Thorpe, M. Aguennouz, R. Martin, D. Hoffmann, P. Morris, A. Destée, D. J. Charron, U. Senin, A. P. SempereE, M. Dreyfus, A. L. Benabid, M. Gomez, S. Heindle, M. C. Morel-Kopp, M. Hennerici, A. I. Santos, M. Djannelidze, N. Artemis, John Collinge, T. Rundek, M. Y. Voloshin, P. de Castro, Th. Wiethege, D. A. S. Compston, D. Schiffer, A. J. Hughes, D. Jimenez, V. Parlato, A. Papadimitriou, J. M. Gergaud, R. Sterzi, J. Arpa, G. de Pinieux, F. Buggle, P. Gimbergues, H. Ruottinen, R. Marzella, W. Koehler, Y. Yurekli, A. Haase, Z. Privorkin, G. K. Harvey, B. Chave, A. J. Grau, E. M. Stadlan, J. List, C. Zorzi, B.W. van Oosten, P. Derkinderen, B. Casati, J. M. Maloteaux, K. Vahedi, W. L. J. van Putten, J. C. Sabourin, D. Lorenzetti, Plenevaux, J. W. B. Moll, A. Morento Fernandez, M. Lema, M. A. Horsfleld, P. De Jongh, S. Gikova, K. Kutluk, Monique M.B. Breteler, P. Saddier, A. Berbinschi, R. E. Cull, P. Echaniz, H. Kober, C. Minault, V. Kramer, A. L. Edal, S. Passero, T. Eckardt, K. E. Davies, A. Salmaggi, R. Kaiser, A. A. Grasso, Claudio Mariani, G. Egersbach, Hakan Gurvit, O. Dereeper, C. Vital, L. Wrabetz, A. Vecino, M. Aguilar, G. Bielicki, H. Becher, J. Castro, S. Iotti, M. G. Natali-Sora, E. Berta, S. Carlomagno, L. Ayuso-Peralta, P. H. Rondepierre, I. Bonaventura, B. V. Deuren, N. Van Blercom, M. Sciaky, J. Faber, M. Alberoni, M. Nieto, F. Sellal, C. Stelmasiak, M. Takao, J. Bradley, D. Zegers de Beyl, H. Porsche, G. Goi, H. Pongratz, F. Chapon, S. Happe, Robin S. Howard, B. Weder, S. Vlaski-Jekic, J. M. Ferro, R. Nemni, A. Daif, Herbert Budka, W. Van Paesschen, B. Waldecker, F. Carceller, J. Lacau, F. Soga, J. Peres Serra, E. Timmerman, A. M. vd Vliet, J. L. Emparanza, N. Vanacore, A. Pizzuti, N. Marti, A. Davalos, N. Ayraud, U. Zettl, J. Vivancos, Z. Katsarou, H. M. Mehdorn, G. Geraud, M. Merlini, M. Schröter, A. Ebner, M. Lanteri-Minet, R. Soler, G. P. Anzola, S. L. Hauser, L. Cahalon, S. DiDonato, R. Cantello, M. Marchau, J. Gioanni, F. Heidenreich, J. Manuel Martinez Lage, P. Descoins, F. Woimant, J. F. Campo, M. H. Verdier-taillefer, M. S. F. Barkhof, G. J. Kemp, A. O. Ceballos-Baumann, J. Berciano, M. Guidi, Tarek A. Yousry, B. Chandra, A. Rapoport, P. Canhao, A. Spitzer, T. Maeda, J. M. Pereira Monteiro, V. Paquis, Th. Mokrusch, F. J. Arrieta, I. Sangla, F. Canizares-Liebana, Lang Chr, André Delacourte, V. Fetoni, P. Kovachev, D. Kidd, L. Ferini-Strambi, E. Donati, E. Idman, A. Chio, C. Queiros, D. Michaelis, S. Boyacigil, A. Rodrigo, S. M. Yelamos, B. Chassande, P. Louwen, C. Tranchant, E. Ciafalon, A. Lombardo, A. Twijnstra, A. L. Fernandez, H. Kott, A. Cannas, N. Zsurger, T. Zileli, E. Metin, P. C. Bain, G. Fromont, B. Tedesi, A. Liberani, X. Navarro, M. C. Rowbotham, V. Hachinski, F. Cavalcanti, W. Rostene, R. M. Gardiner, F. Gonzalez, B. Köster, E. A. van der Veen, J. P. Lefaucheur, C. Marescaux, D. Boucquey, E. Parati, S. Yamaguchi, A. S. Orb, R. Grant, G. D. P. Smith, P. Goethals, M. Haguenau, G. Georgiev, I. N. van Schaik, Guy A. Rouleau, E. Iceman, G. Fayet, M. G. Kaplitt, C. Baracchini, H. Magnusson, G. Meneghetti, N. Malichard, M. L. Subira, D. Mancia, A. Berenguer, D. Navarrete Palau, H. Franssen, G. Kiziltan, M. P. Lopez, J. Montalt, S. Norby, R. Piedra Crespo, T. L. Rothstein, R. Falip, B. YalÇiner, F. Chedru, I. W. Thorpe, F. W. Heatley, D. S. C. Ochoa, C. Labaune, M. Devoti, O. Lider, Jakob Korf, N. Suzuki, E. A. Maguire, A. Moulignier, J. C. van Swieten, F. Monaco, J. Cartron, A. Steck, B. Uludag, M. Alexandra, H. Reichmann, T. Rossi, L. E. Claveria, A. M. Crouzel, M. A. Mena, J. Gasnault, J. W. Kowalski, S. I. Mellgren, V. Feigin, L. Demisch, J. Montalban, J. Renato, J. Mathieu, N. Goebels, L. Bava, K. Kunre, M. Pulik, S. Di Donato, C. Tzekov, H. Veldman, S. Giménez-Roldan, B. Lechevalier, L. Redondo, B. Pillon, M. Gugenheim, E. Roullet, J. M. Valdueza, C. Gori, H. J. Friedrich, L. de Saint Martin, F. Block, E. Basart, M. Heilmann, B. Becq Giraudon, C. Rodolico, G. Stevanin, Elizabeth K. Warrington, A. T. M. Willemsen, K. Kunze, C. Ben Hamida, M. Alam, J. R. ùther, A. Battistel, G. Della Marca, Richard S. J. Frackowiak, F. Palau, T. Brandt, Chicoutimi, L. Bove, L. Callea, A. Jaspert, T. Klopstock, K. Fassbender, Alan J. Thomas, A. Ferbert, V. Nunes, Douglas Russell, P. Garancini, C. Sanz-Sebastian, O. Santiag, G. Dhaenens, G. Seidel, I. Savic, A. Florea-Strat, M. Rousseaux, N. Catala, E. O'Sullivan, M. J. Manifacier, H. Kurtel, T. Mendel, P. Chariot, M. Salas, D. Brenton, R. Lopez, J. Thorpe, Jimmy D. Bell, E. Hofmann, E. Botia, J. Pacquereau, A. Struppler, C. d'Aniello, D. Conway, A. Garcia-Merino, K. Toyooka, S. Hodgkinson, E. Ciusani, Stefano Bastianello, A. Andrade Filho, M. Zaffaroni, G. Pleiffer, F. Coria, A. Schwartz, D. Baltadjiev, I. Rother, K. Joussen, J. Touchon, K. Kutlul, P. Praamstra, H. Sirin, S. Richard, C. Mariottu, L. Frattola, S. T. Dekesky, G. Wieneke, M. Chatel, O. Godefroy, C. Desnuelle, S. OzckmekÇi, C. H. Zielinski, P. van Deventer, S. Jozwiak, I. Galan, J. M. Grau, V. Vieira, T. A. Treves, S. Ertan, A. Pujol, S. Blecic, E. M. Zanette, F. Ceriani, W. Camu, L. Aquilone, A. Benomar, F. Greco, A. Pascual-Leone Pascual, T. Yanagihara, F. A. Delfino, R. Damels, S. Merkelbach, J. Beltran, A. Barrientos, S. Brugge, B. Hildebrandt-Müller, M. H. Nascimento, M. Rocchi, F. Cervantes, E. Castelli, R. M. Pressler, S. Yeil, A. del Olmo, J. L. Herranz, L. J. Kappelle, Y. Demir, N. Inoue, R. Hershkoviz, A. Luengo, S. Bien, F. Viallet, P. Malaspina, G. De Michele, G. Nolfe, P. Adeleine, T. Liehr, G. Fenelon, H. Masson, Kailash P. Bhatia, W. Haberbosch, S. Mederer, R. S. J. Frackowiak, Tanya Stojkovic, S. Previtali, A. E. Harding, W. Kohler, N. P. Quin, T. R. Marra, J. P. Moisan, A. Melchor, M. L. Viguera, Mary G. Sweeney, G. L. Romani, J. Hezel, R. A. Dierckx, R. Torta, A. Kratzer, T. Pauwels, D. Decoo, Adriana Campi, Neil Kitchen, J. Haas, U. Neubauer, J. J. Merland, A. Yagiz, A. Antonuzzo, A. Zangaladze, J. Parra, Pablo Martinez-Lage, D. J. Brooks, S. Hauser, R. Di Pierri, M. Campero, R. Caldarelli-Stefano, A. M. Colangelo, J. L. Pozo, C. Estol, F. Picard, A. Palmieri, J. Massons, JT Phillips, G. B. Groozman, R. Pentore, L. M. Ossege, C. Bayon, Hans-Peter Hartung, R. Konyalioglu, R. Lampis, D. Ancri, M. Miletta, F. J. Claramonte, W. Retz, F. Hentges, JM Cooper, M. Cordes, M. Limburg, M. Brock, G. R. Coulton, K. Helmke, Rosa Larumbe, A. Ohly, F. Landgraf, A. M. Drewes, Claudia Trenkwalder, M. Keidel, T. Segura, C. Scholz, J. HÄgele, D. Baudoin-Martin, P. Manganelli, J. Valdueza, M. Farinotti, U. Zwiener, M. P. Schiavalla, Y. P. Young, O. Barlas, G. Hertel, E. H. Weiss, M. Eiselt, A. Lossos, M. Bartoli, L. Krolicki, W. Villafana, W. Peterson, Nicoletta Meucci, C. Agbo, R. Luksch, F. Fiacco, G. Ponsot, M. Lopez, Howard L. Weiner, M. D. Alonso, K. Petry, Sanjay M. Sisodiya, P. Giustini, S. Tyrdal, R. Poupon, J. Blanke, P. Oubary, A. A. Kruize, H. Trabucchi, R. R. C. Stewart, H. Grehl, B. M. Kulig, V. Vinhas, D. Spagnoli, B. Mahe, J. Tatay, C. Hess, M. D. Albadalejo, G. Birbamer, M. Alonso, F. Valldeoriola, J. Figols, I. Wirguin, E. Diez Tejedor, C. S. Weiller, L.H. van den Berg, P. Barreiro, L. Pianese, S. Cocozza, R. Kohnen, E. Redolfi, F. Faralli, G. Gosztonyl, A. J. Gur, A. Keyser, V. Fichter-Gagnepain, B. Wildemann, E. Omodeo-Zorini, Gregoire, J. Schopohl, F. Fraschini, G. Wunderlich, B. Jakubowska, F. P. Serra, N. B. Jensen, O. Delattre, C. Leno, A. Dario, P. Grafe, F. Graus, M. C. Vigliani, J. L. Dobato, Philip N. Hawkins, R. Marés, A. Rimola, N. Meussi, G. Aimard, W. Hospers, A. M. Robertson, C. Kaplan, W. Lamadé, Karen E. Morrison, Amadio, E. Kieffer, F. Dromer, P. Bernasconi, M. Repeto, Davide Pareyson, Jeremy Rees, A. Guarneri, P. Odin, P. Bouche, L. Nogueira, J. Munoz, L. Leocani, M. J. Arcusa, R. S. J. Frackowiack, John S. Duncan, D. Karacostas, D. Edwin, I. Costa, M. Menetrey, P. Grieb, A. M. Salvan, S. Cunha, P. Merel, P. Pfeiffer, A. Astier, F. Federico, A. Mrabet, M. G. Buzzi, L. Knudsen, I. F. Pye, L. Falqui, C. R. Hornig, C. E. Shaw, C. Brigel, T. C. Britton, R. Codoceo, T. Pampols, Vincent J. Cunningham, N. Archidiacono, G. Chazot, J. B. Posner, L. L. O. Befalo, M. Monclus, C. Cabezas, H. Moser, H. Stodal, J. Ley-Pozo, L. Brusa, R. Di Mascio, P. Giannini, J. Fernandez, R. Santiago Luis, J. Garcia Tigera, J. Wilmink, P. Pignatelli, M. El Amrani, V. Lucivero, M. Baiget, R. Lodi, P. H. Cabre, L. Grande, A. Korczyn, R. Fahlbusch, C. Milanese, W. Huber, J. Susseve, H. C. Nahser, K. Mondrup, X. O. Breakefield, J. Sarria, T. H. Vogt, A. Alessandri, M. Daffertshofer, I. Nelson, M. L. Monticelli, O. Dammann, G. G. Farnarier, G. Felisari, A. Quattrini, A. Boiardi, P. Mazetti, H. Liu, J. Duarte, M. E. Gaunt, H. Strik, N. Yulug, A. Urman, J. Posner, Aida Suarez Gonzalez, Ma. L. Giros, Z. Matkovic, D. Kompf, A. D. Korczyn, A. Steinbrecher, R. Wenzel, M. C. de Rijk, R. Doronzo, J. Julien, O. Hasegawa, M. Kramer, V. Collado-Scidel, M. Alonso de Lecinana, L. Dell'Arciprete, S. Rapuzzi, S. Bahar, H. Willison, M. T. Ramacci, J.J. Martin, Lopez-Bresnahan, C. Malapani, R. Haaxma, T. Rosenberg, J. Patrignani, R. Vichi, Martin R. Farlow, J. Roquer, L. Krols, M. Pimenta, C. Bucka, U. Klose, M. Roberts, J. Salas-Puig, R. Ghnassia, A. Mercuri, C. Maltempo, I. Tournev, P. Homeyer, D. Caparros-Lefevre, E. P. O. Sullivan, T. Vashadze, Ph. Lyrer, A. Deltoro, H. Kondo, M. Steinling, A. Graham, G. C. Miescher, A. Pace, D. Branca, G. Avello, H. H. Kornhuber, D. Fernandes, H. Friedrich, R. Chorao, H. O. Lüders, R. T. Bax, J. A. Macias, N. Yilmaz, J. Veroust, M. Miller, S. Confort-Gouny, J. L. Sastre, D. Servello, G. Boysen, S. Koeppen, V. Planté-Bordeneuve, H. Albrecht, R. H. M. King, G. Orkodashili, R. Doornbos, H. Toyooka, V. Larrue, M. Sabatelli, K. Williams, M. Stevens, V. Maria, M. Comabella, C. Lammers, R. M. L. Poublon, E. Tizzano, P. Pazzaglia, F. Zoeller, M. B. Delisle, J. P. Goument, J. M. Minderhoud, A. Sghirlanzoni, V. Meininger, M. Al Deeb, C. Bertelt, A. Cagni, A. Algra, F. Morales, K. A. Flugel, M. Maidani, M. Noya, Z. Seidl, U. Roelcke, D. Cannata, E. Katiane EmbiruÇu, E. M. Wicklein, K. Willmes, L. Hanoglu, J. F. Pellissier, Yves Agid, E. Cuadrado, S. Brock, D. Maimone, Z. G. Nadareishvili, E. Matta, S. Hilmi, V. Assuerus, F. Lomena, R. Springer, F. Cabrera-Valdivia, Oscar L. Lopez, M. Casazza, F. Vivancos, Ralf Gold, T. Crawford, B. Moulard, M. Poisson, W. l. McDonald, D. E. Grobbe, Alan Connelly, H. Ozcan, S. Abeta, H. Severo Ochoa, A. C. van Loenen, E. Libson, M. J. Marti, B. George, C. Ferrarese, B. Jacobs, L. Divano, T. Ben-Hur, A. L. Bootsma, V. Martinez, A. Conti, R. P. Maguire, B. Schmidt, D. M. Campos, D. A. Guzman, E. Meary, C. Richart, P. B. Christensen, T. Schroeder, Massimo Zeviani, K. Jensen, R. Aliaga, S. Seitz-Dertinger, J. W. Griffin, C. Fryze, H. Baas, S. Braun, A. M. Porrini, B. Yemez, M. J. Sedano, C. Creisson, A. Del Santo, A. Mainz, R. Kay, S. Livraghi, R. de Waal, D. Macgregor, H. Hefter, R. Garghentino, U. Ruotsalainen, M. Matsumoto, M. G. Beaudry, P. M. Morrison, J. C. Petit, C. Walon, Ph. Chemouilli, F. Henderson, R. Massa, A. Cruz Martinez, U. Liska, F. Hecht, Ernst Holler, V. S. de Bruin, B. B. Sheitman, S. M. Bentzen, C. Bayindir, F. Pallesta, P. E. Roland, J. Parrilla, P. Zunker, L. F. Burchinskaya, G. Mellino, S. Ben Ayed, D. Bonneau, P. Nowacki, M. Goncalves, P. Riederer, N. Mavroudakis, J. Togores, L. Rozewicz, S. Robeck, Y. Perez Gilabert, L. Rampello, A. Rogopoulos, S. Martinez, F. Schildermans, C. Radder, P. B. Hedlund, J. Cambier, M. Aabed, G. D. Jackson, P. Gasparini, P. Santacruz, J. Vandevivere, H. Dural, A. Mantel, W. Dorndorf, N. Ediboglu, A. Lofgren, J. Bogousslavsky, P. Thierauf, L. Goullard, R. Maserati, B. Moering, M. Ryba, J. Serra, G. G. Govan, A. Pascual-Leone, S. Schaeffer, M. R. Rosenfeld, A. P. Correia, K. Ray Chaudhuri, L. Campbell, R. Spreafico, B. Genetet, A. M. Tantot, R. A. G. Hughes, J. A. Vidal, G. Erkol, J. Y. Delattre, B. Yaqub, B. K. Hecht, E. Mayayo, Ph. Scheltens, J. Corral, M. Calaf, L. Henderson, C. Y. Li, U. Bogdahn, R. Sanchez-Roy, M. Navasa, J. Ballabriga, G. Broggi, T. Gudeva, C. Rose, J. Vion-Dury, J. A. Gastaut, J. Pniewski, Nicola J. Robertson, G. Kohncke, M. Billot, S. Gok, E. Castellli, F. Denktas, P. Bazzi, F. Spinelli, I. F. Moseley, C. D. Mardsen, B. Barbiroli, O. M. Koriech, A. Miller, Hiroaki Yoshikawa, F. X. Borruat, J. Zielasek, P. Le Coz, J. Pascual, A. Drouet, L. T. Giron, F. Schondube, R. Midgard, M. Alizadeh, M. Liguori, Lionel Ginsberg, L. Harms, C. Tilgner, G. Tognoni, F. Molteni, Mar Tintoré, M. Psylla, C. Goulon-Goeau, M. V. Aguilar, Massimo Filippi, K. H. Mauritz, Thomas V. Fernandez, C. Basset, S. Rossi, P. Meneses, B. Jandolo, T. Locatelli, D. Shechtcr, C. Magnani, R. Ferri, Bruno Dubois, J. M. Warier, S. Berges, F. Idiman, M. Schabet, R. R. Diehl, P. D'aurelio, M. Musior, Reinhard Hohlfeld, P. Smeyers, M. Olivé, A. Riva, C. A. Broere, N. Egund, S. Franceschetti, V. Bonavita, Nicola Canal, E. Timmermans, M. Ruiz, S. Barrandon, G. Vasilaski, B. Deweer, L. Galiano, S. F. T. M. de Bruijn, L. Masana, A. Goossens, B. Heye, K. Lauer, Heinz Gregor Wieser, Stephen R. Williams, B. Garavaglia, A. P. Sempere, F. Grigoletto, P. Poindron, R. Lopez-Pajares, I. Leite, T. A. McNell, C. Caucheteur, J. M. Giron, A. D. Collins, P. Freger, J. Sanhez Del Rio, D. A. Harn, K. Lindner, S. S. Scherer, G. Serve, M. Juncadella, X. Estivill, R. Binkhorst, M. Anderson, B. Tekinsoy, C. Sagan, T. Anastopoulos, G. Japaridze, S. Guillou, F. Erminio, Jon Sussman, P. G. Oomes, D. S. Rust, S. Mascheroni, O. Berger, M. Peresson, K. V. Toyka, T. W. Polder, M. Huberman, B. Arpaci, H. Ramtami, I. Martinez, Ph. Violon, P. P. Gazzaniga Pozzill, R. Ruda, P. Auzou, J. Parker, S. P. Morrissey, Jiahong Zhu, F. Rotondi, P. Baron, W. Schmid, P. Doneda, M. Spadaro, M. C. Nargeot, I. Banchs, J.S.P. van den Berg, R. Ferrai, M. Robotti, M. Fredj, Pedro M. Rodríguez Cruz, B. Erne, D. G. Piepgras, M. C. Arne-Bes, J. Escudero, C. Goetz, A. R. Naylor, M. Hallett, O. Abramsky, E. Bonifacio, L. E. Larsson, R. Pellikka, P. Valalentino, D. Guidetti, B. Buchwald, C. H. Lücking, D. Gauvreau, F. Pfaff, A. Ben Younes-Chennoufi, R. Kiefer, R. Massot, K. A. Hossmann, L. Werdelin, P. J. Baxter, U. Ziflo, S. Allaria, C. D. Marsden, M. Cabaret, S. P. Mueller, E. Calabrese, R. Colao, S. I. Bekkelund, M. Yilmaz, O. Oktem-Tanor, R. Gine, M. E. Scheulen, J. Beuuer, A. Melo, Z. Gulay, M. D. Have, C. Frith, D. Liberati, J. Gozlan, P. Rondot, Ch. Brunholzl, M. Pocchiari, J. Pena, L. Moiola, C. Salvadori, A. Cabello, T. Catarci, S. Webb, C. Dettmers, N. A. Gregson, Alexandra Durr, F. Iglesias, U. Knorr, L. Ferrini-Strambi, F. Kruggel, P. Allard, A. Coquerel, P. Genet, F. Vinuels, C. Oberwittler, A. Torbicki, P. Leffers, B. Renault, B. Fauser, C. Ciano, G. Uziel, J. M. Gibson, F. Anaya, C. Derouesné, C. N. Anagnostou, M. Kaido, W. Eickhoff, G. Talerico, M. L. Berthier, A. Capdevila, M. Alons, D. Rezek, E. Wondrusch, U. Kauerz, D. Mateo, M. A. Chornet, Holon, N. Pinsard, I. Doganer, E. Paoino, H. Strenge, C. Diaz, J. R. Brasic, W. Heide, I. Santilli, W. M. Korn, D. Selcuki, M. J. Barrett, D. Krieger, T. Leon, T. Houallah, M. Tournilhac, C. Nos, D. Chavot, F. Barbieri, F. J. Jimenez-Jimenez, J. Muruzabal, K. Poeck, A. Sennlaub, L. M. Iriarte, L. G. Lazzarino, C. Sanz, P. A. Fischer, S. D. Shorvon, R. Hoermann, F. Delecluse, M. Krams, O. Corabianu, F. H. Hochberg, Christopher J. Mathias, B. Debachy, C. M. Poser, L. Delodovici, A. Jimenez-Escrig, F. Baruzzi, F. Godenberg, D. Cucinotta, P. J. Garcia Ruiz, K. Maier-Hauff, P. R. Bar, R. Mezt, R. Jochens, S. Karakaneva, C. Roberti, E. Caballero, Joseph E. Parisi, M. Zamboni, T. Lacasa, B. Baklan, J. C. Gautier, J. A. Martinez-Matos, W. Pollmann, G. Thomas, L. Verze, E. Chleide, R. Alvarez Sala, I. Noel, E. Albuisson, O. Kastrup, S. I. Rapoport, H. J. Braune, H. Lörler, M. Le Merrer, A. Biraben, S. Soler, S. J. Taagholt, U. Meyding-Lamadé, K. Bleasdale-Barr, Isabella Moroni, Y. Campos, J. Matias-Guiu, G. Edan, M. G. Bousser, John B. Clark, J. Garcia de Yebenes, N. K. Olsen, P. Hitzenberger, S. Einius, Aj Thompson, Ch. J. Vecht, T. Crepin-Leblond, Klaus L. Leenders, A. Di Muzio, L. Georgieva, René Spiegel, K. Sabey, D. Ménégalli, J. Meulstee, U. Liszka, P. Giral, C. Sunol, J. M. Espadaler, A. D. Crockar, K. Varli, G. Giraud, P. J. Hülser, A. Benazzouz, A. Reggio, M. Salvatore, K. Genc, M. Kushnir, S. Barbieri, J. Ph. Azulay, M. Gianelli, N. Bathien, A. AlMemar, F. Hentati, I. Ragueneau, F. Chiarotti, R. C. F. Smits, A. K. Asbury, F. Lacruz, B. Muller, Alan J. Thompson, Gordon Smith, K. Schmidt, C. Daems Monpeun, Juergen Weber, A. Arboix, G. R. Fink, A. M. Cobo, M. Ait Kaci Ahmed, E. Gencheva, Israel-Biet, G. Schlaug, P. De Jonghe, Philip Scheltens, K. Toyka, P. Gonzalez-Porque, A. Cila, J. M. Fernandez, P. Augustin, J. Siclia, S. Medaglini, D. E. Ziogas, A. Feve, L. Kater, G. J. E. Rinkel, D. Leppert, Rüdiger J. Seitz, S. Ried, C. Turc-Carel, G. Smeyers, F. Godinho, M. Czygan, M. Rijntjes, E. Aversa, M. Frigo, Leif Østergaard, J. L. Munoz Blanco, A. Cruz-Matinez, J. De Reuck, C. Theillet, T. Barroso, V. Oikonen, Florence Lebert, M. Kilinc, C. Cordon-Cardon, G. Stoll, E. Thiery, F. Pulcinelli, J. Solski, M. Schmiegelow, L. J. Polman, P. Fernandez-Calle, C. Wikkelso, M. Ben Hamida, M. Laska, E. Kott, W. Sulkowski, C. Lucas, N. M. Bornstein, D. Schmitz, M. W. Lammers, A. de Louw, R. J. S. Wise, P. A. van Darn, C. Antozzi, P. Villanueva, P. H. E. Hilkens, C. Constantin, W. Ricart, A. Wolf, M. Gamba, P. Maguire, Alessandro Padovani, B. M. Patten, Marie Sarazin, H. Ackermann, L. Durelli, S. Timsit, Sebastian Jander, B. W. Scheithauer, G. Demir, J. P. Neau, P. Barbanti, A. Brand, N. AraÇ, V. Fischer-Gagnepain, R. Marchioli, G. Serratrice, C. Maugard-Louboutin, G. T. Spencer, D. Lücke, G. Mainardi, K. Harmant Van Rijckevorsel, G. B. Creel, R. Manzanares, Francesco Fortunato, A. May, J. Workman, K. Johkura, E. Fernandez, Carlo Colosimo, L. Calliauw, L. Bet, Félix F. Cruz-Sánchez, M. Dhib, H. Meinardi, F. Carrara, J. Kuehnen, C. Peiro, H. Lassmann, K. Skovgaard Olsen, A. McDonald, L. Sciulli, A. Cobo, A. Monticelli, B. Conrad, J. Bagunya, J. Benitez, V. Desnizza, B. Dupont, O. Delrieu, D. Moraes, J. J. Heimans, F. Garcia Rio, M. Matsumto, A. Fernandez, R. Nermni, R. Chalmers, M. J. Marchau, F. Aguado, P. Velupillai, P. J. Martin, P. Tassan, V. Demarin, A. Engelien, T. Gerriets, Comar, J. L. Carrasco, J. P. Pruvo, A. Lopez de Munain, D. Pavitt, J. Alarcon, Chris H. Polman, B. Guldin, N. Yeni, Hartmut Brückmann, N. Wilczak, H. Szwed, R. Causaran, G. Kyriazis, M. E. Westarp, M. Gasparini, N. Pecora, J. M. Roda, E. Lang, V. Scaioli, David R. Fish, D. Caputo, O. Gratzl, R. Mercelis, A. Perretti, G. Steimetz, I. Link, C. Rigoletto, A. Catafau, G. Lucotte, M. Buti, G. Fagiolari, A. Piqueras, C. Godinot, J. C. Meurice, Erodriguez J. Dominigo, F. Lionnet, H. Grzelec, David J. Brooks, P. M. G. Munro, F. X. Weilbach, M. Maiwald, W. Split, B. Widjaja-Cramer, V. Ozturk, J. Colas, E. Brizioli, J. Calleja, L. Publio, M. Desi, R. Soffietti, P. Cortinovis-Tourniaire, E. F. Gonano, G. Cavaletti, S. Uselli, K. Westerlind, H. Betuel, C. O. Dhiver, H. Guggenheim, M. Hamon, R. Fazio, P. Lehikoinen, A. Esser, B. Sadzot, G. Fink, Angelo Antonini, D. Bendahan, V. Di Carlo, G. Galardi, A. F. Boller, M. Aksenova, Del Fiore, V. de la Sayette, H. Chabriat, A. Nicoletti, A. Dilouya, M. L. Harpin, E. Rouillet, J. Stam, A. Wolters, M. R. Delgado, Eduardo Tolosa, G. Said, A. J. Lees, L. Rinaldi, A. Schulze-Bonhage, MA Ron, C. Lefebvre, E. W. Radü, R. Alvarez, M. L. Bots, P. Reganati, S. Palazzi, A. Poggi, N. J. Scolding, V. Sazdovitch, T. Moreau, E. Maes, M. A. Estelies, P. Petkova, Jose-Felix Marti-Masso, G De La Meilleure, N. Mullatti, M. Rodegher, N. C. Notermans, T. A. T. Warner, S. Aktan, J. P. Louboutin, L. Volpe, C. Scheidt, W. Aust, C. M. Wiles, U. Schneider, S. K. Braekken, W. R. Willems, K. Usuku, Peter M. Rothwell, C. Talamon, M. L. Sacchetti, A. Codina, M. H. Marion, A. Santoro, J. Roda, A. Bordoni, D. J. Taylor, S. Ertas, H. H. Emmen, J. Vichez, V. BesanÇon, R. E. Passingham, M. L. Malosio, A. Vérier, M. Bamberg, A. W. Hansen, E. Mostacero, G. Gaudriault, Marie Vidailhet, B. Birebent, K. Strijckmans, F. Giannini, T. Kammer, I. Araujo, J. Nowicki, E. Nikolov, A. Hutzelmann, R. Gherardi, J. Verroust, L. Austoni, A. Scheller, A. Vazquez, S. Matheron, H. Holthausen, J. M. Gerard, M. Bataillard, S. Dethy, V. H. Patterson, V. Ivanez, N. P. Hirsch, F. Ozer, M. Sutter, C. Jacomet, M. Mora, Bruno Colombo, A. Sarropoulos, T. H. Papapetropoulos, M. Schwarz, D. S. Dinner, N. Acarin, B. Iandolo, J. O. Riis, P. R. J. Barnes, F. Taroni, J. Kazenwadel, L. Torre, A. Lugaresi, I. L. Henriques, S. Pauli, S. Alfonso, Pedro Quesada, A. S. T. Planting, J. M. Castilla, Thomas Gasser, M. Van der Linden, A. Alfaro, E. Nobile-Orazio, G. Popova, W. Vaalburg, F. G. A. van der Mech, L. Williams, F. Medina, J. P. Vernant, J. Yaouanq, B. Storch-Hagenlocher, A. Potemkowski, R. Riva, M. H. Mahagne, M. Ozturk, Ve. Drory, N. Konic, C. Jungreis, A. Pou Serradell, J. L. Gauvrit, G. J. Chelune, S. Hermandez, T. Dingus, L. Hewer, Ch. Koch, M. N. Metz-Lutz, G. Parlato, M. Sinaki, Charles Pierrot-Deseilligny, H. C. Diener, J. Broeckx, J. Weill-Fulazza, M. L. Villar, M. Rizzo, O. Ganslandt, C. Duran, N. A. Fletcher, G. Di Giovacchino, Susan T. Iannaccone, C. Kolig, N. Fabre, H. A. Crockard, Rita Bella, M. Tazir, E. Papagiannuli, K. Overgaard, Emma Ciafaloni, I. Lorenzetti, F. Viader, P. A. H. Millac, I. Montiel, L. H. Visser, M. Palomar, P. L. Murgia, H. Pedersen, Rafael Blesa, S. Seddigh, W. O. Renier, I. Lemahieu, H. M. L. Jansen, L. Rosin, J. Galofre, K. Mattos, M. Pondal, G. M. Hadjigeorgiou, D. Francis, L. Cantin, D. Stegeman, M. Rango, A. B. M. F. Karim, S. Schraff, B. Castellotti, I. Iriarte, E. Laborde, T. J. Tjan, R. Mutani, D. Toni, B. Bergaasco, J. G. Young, C. Klotzsch, A. Zincone, X. Ducrocq, M. Uchuya, O. J. Kolar, A. Quattrone, T. Bauermann, Nereo Bresolin, J. Vallée, B. C. Jacobs, A. Campos, Werner Poewe, J. A. Villanueva, A. W. Kornhuber, A. Malafosse, E. Diez-Tejedor, G. Jungreia, M. J. A. Puchner, A. Komiyama, O. Saribas, V. Volpini, L. Geremia, S. Bressi, A. Nibbio, Timothy E. Bates, T. z. Tzonev, E. Ideman, G. A. Damlacik, G. Martino, G. Crepaldi, T. Martino, Kjell Någren, E. Idiman, D. Samuel, J. M. Perez Trullen, Y. van der Graaf, J. O. Thorell, M. J. M. Dupuis, E. Sieber, R. D'Alessandro, C. Cazzaniga, J. Faiss, A. Tanguy, A. Schick, I. Hoksergen, A. Cardozo, R. Shakarishvili, G. K. Wennlng, J. L. Marti-Vilalta, J. Weissenbach, I. L. Simone, Amalia C. Bruni, Darius J. Adams, C. Weiller, A. Pietrangeli, F. Croria, C. Vigo-Pelfrey, Patricia Limousin, A. Ducros, G. Conti, O. Lindvall, E. Richter, M. Zuffi, A. Nappo, T. Riise, J. Wijdenes, M. J. Fernandez, J. Rosell, P. Vermersh, S. Servidei, M. S. C. Verdugo, F. Gouttiere, W. Solbach, M. Malbezin, I. S. Watanabe, A. Tumac, W. I. McDonald, D. A. Butterfield, P. P. Costa, F. deRino, F. Bamonti, J. M. Cesar, C. H. Lahoz, I. Mosely, M. Starck, M. H. Lemaitre, K. M. Stephan, S. Tex, R. Bokonjic, I. Mollee, L. Pastena, M. Gutierrez, F. Boiler, M. C. Martinez-Para, M. Velicogna, O. Obuz, A. Grinspan, M. Guarino, L. M. Cartier, E. Ruiz, D. Gambi, S. Messina, M. Villa, Michael G. Hanna, J. Valk, Leone Pascual, M. Clanet, Z. Argov, B. Ryniewicz, E. Magni, B. Berlanga, K. S. Wong, C. Gellera, C. Prevost, F. Gonzalez-Huix, R. Petraroli, J. E. G. Benedikz, I. Kojder, C. Bommelaer, L. Perusse, M. R. Bangioanni, Guy M. McKhann, A. Molina, C. Fresquet, E. Sindern, Florence Pasquier, M. J. Rosas, M. Altieri, O. Simoncini, M. Koutroumanidis, C. A. F. Tulleken, M. Dary-Auriol, S. Oueslati, H. Kruyer, I. Nishisho, C. R. Horning, A. Vital, G. V. Czettritz, J. Ph. Neau, B. Mihout, A. Ameri, M. Francis, S. Quasthoff, D. Taussig, S. Blunt, P. Valentin, C. Y. Gao, O. Heinzlef, H. d'Allens, C. Coudero, M. Erfas, G. Borghero, P. J. Modrego Pardo, M. C. Patrosso, N. L. Gershfeld, P. A. J. M. Boon, O. Sabouraud, M. Lara, J. Svennevig, G. L. Lenzi, A. Barrio, H. Villaroya, JosÇ M. Manubens, O. Boespflug-Tanguy, M. Carreras, D. A. Costiga, J. P. Breux, S. Lynn, C. Oliveras Ley, A. G. Herbaut, J. Nos, C. Tornali, Y. A. Hekster, J. L. Chopard, J. M. Manubens, P. Chemouilli, A. Jovicic, F. Dworzak, S. Smirne, S. E. Soudain, B. Gallano, D. Lubach, G. Masullo, G. Izquierdo, A. Pascual Leone Pascual, A. Sessa, V. Freitas, O. Crambes, L. Ouss, G. W. Van Dijk, P. Marchettini, P. Confalonieri, M. Donaghy, A. Munnich, M. Corbo, and M. E. L. van der Burg
Subjects: Neurology, business.industry, Media studies, Library science, Medicine, Neurology (clinical), business
Published: 1994

35. Book Reviews

Author: Y. Pirson, V. Castronoyo, J.J. Martin, J. De Plaen, and E. Marion
Subjects: General Medicine
Published: 1994

36. Differential features of carotid and vertebral artery dissections: the CADISP study

Author: Stefan T. Engelter, Manja Kloss, Didier Leys, Emmanuel Touzé, E. Del Zotto, S. Canaple, Sherine Abboud, Jean Dallongeville, Giacomo Giacalone, Maurice Giroud, J.J. Martin, Philippe Lyrer, Tiina M. Metso, Yves Samson, Alessandro Pezzini, Turgut Tatlisumak, Caspar Grond-Ginsbach, Valeria Caso, Antti J. Metso, Stéphanie Debette, Tobias Brandt, and Marie Bodenant
Subjects: Adult, Male, medicine.medical_specialty, Cervical Artery, Vertebral artery, Vertebral artery dissection, ICAD, Carotid Artery, Internal, Dissection, Sex Factors, Modified Rankin Scale, medicine.artery, medicine, Humans, Prospective Studies, cardiovascular diseases, Risk factor, Retrospective Studies, Vertebral Artery Dissection, Internal carotid artery dissection, business.industry, Age Factors, Middle Aged, medicine.disease, Surgery, Dissection, Female, Neurology (clinical), business, Follow-Up Studies
Abstract: Objective: To examine whether risk factor profile, baseline features, and outcome of cervical artery dissection (CEAD) differ according to the dissection site. Methods: We analyzed 982 consecutive patients with CEAD included in the Cervical Artery Dissection and Ischemic Stroke Patients observational study (n = 619 with internal carotid artery dissection [ICAD], n = 327 with vertebral artery dissection [VAD], n = 36 with ICAD and VAD). Results: Patients with ICAD were older ( p p = 0.006), more frequently had a recent infection (odds ratio [OR] = 1.59 [95% confidence interval (CI) 1.09–2.31]), and tended to report less often a minor neck trauma in the previous month (OR = 0.75 [0.56–1.007]) compared to patients with VAD. Clinically, patients with ICAD more often presented with headache at admission (OR = 1.36 [1.01–1.84]) but less frequently complained of cervical pain (OR = 0.36 [0.27–0.48]) or had cerebral ischemia (OR = 0.32 [0.21–0.49]) than patients with VAD. Among patients with CEAD who sustained an ischemic stroke, the NIH Stroke Scale (NIHSS) score at admission was higher in patients with ICAD than patients with VAD (OR = 1.17 [1.12–1.22]). Aneurysmal dilatation was more common (OR = 1.80 [1.13–2.87]) and bilateral dissection less frequent (OR = 0.63 [0.42–0.95]) in patients with ICAD. Multiple concomitant dissections tended to cluster on the same artery type rather than involving both a vertebral and carotid artery. Patients with ICAD had a less favorable 3-month functional outcome (modified Rankin Scale score >2, OR = 3.99 [2.32–6.88]), but this was no longer significant after adjusting for baseline NIHSS score. Conclusion: In the largest published series of patients with CEAD, we observed significant differences between VAD and ICAD in terms of risk factors, baseline features, and functional outcome.
Published: 2011

37. Detection of herpes simplex virus in the cerebrospinal fluid of patients with encephalitis using the polymerase chain reaction

Author: Paul M. Parizel, Margareta Ieven, G. Mertens, J.J. Martin, S. R. Pattyn, and D. Ursi
Subjects: Adult, Male, Pathology, medicine.medical_specialty, Herpesvirus 2, Human, Herpesvirus 1, Human, medicine.disease_cause, Polymerase Chain Reaction, Virus, Herpesviridae, Cerebrospinal fluid, Pons, Alphaherpesvirinae, medicine, Humans, medicine.diagnostic_test, biology, business.industry, Brain biopsy, Brain, Herpes Simplex, medicine.disease, biology.organism_classification, Magnetic Resonance Imaging, Virology, Herpes simplex virus, Neurology, DNA, Viral, Encephalitis, Female, Neurology (clinical), Viral disease, Oligonucleotide Probes, business
Abstract: Herpes simplex encephalitis is a neurologic emergency demanding immediate institution of specific therapy in order to prevent mortality. Diagnosis, however, is a complex matter with controversy existing over the appropriateness of brain biopsy. We report the demonstration of herpes simplex virus DNA by means of the polymerase chain reaction (PRC) in the cerebrospinal fluid of 3 patients with herpes simplex encephalitis. One of the patients suffered from brain-stem encephalitis with high intensity signals in the pons on magnetic resonance imaging, the second reported case of this entity. The PCR for herpes simplex on a control series of cerebrospinal fluid of 20 patients with other central nervous system infections was negative. PCR of cerebrospinal fluid offers a sensitive, specific and rapid diagnosis of herpes simplex encephalitis, making brain biopsy unnecessary. Still, the importance of strict measures to prevent contamination cannot be stressed enough. It is possible that due to the high sensitivity of the PCR, herpes simplex may be found in other infectious syndromes of the central nervous system.
Published: 1993

38. Crisis Intervention Team of Avilés. Results after three years

Author: A.M. González Álvarez, E. Lago Machado, L. Pérez Gómez, E. Lanza Quintana, and J.J. Martínez Jambrina
Subjects: crisis intervention team Aviles, Psychiatry, RC435-571
Abstract: Introduction This Crisis Intervention Team was born in October 2018 with the aim of intensifying the treatment of people in psychiatric crisis situation. Objectives Provide an intensive and early assessment and approach in a timely manner. It also provides home care if necessary. Methods The team intensively performs scheduled visits, emergencys, telephone interventions and home care. It is in constant coordination with other structures of the mental health and socio-health network. Results A total of 83 patients have been included in our team since its inception. The youngest was 17 years old and the oldest 83 years old (exceptional case in evaluation). The mean age was 45.6 years. 67.4% were female (56 women) and 32.5% male (27 men). The delay in care did not exceed 48 hours. 200 patients were evaluated into suicide protocol, with ages ranging from 15 to 85 years, with a mean age of 45.4 years. The delay in care does not exceed 10 days. Conclusions This is a team that offers a rapid response, dedicates the necessary time for a correct evaluation of the risk, of the evolution and tries to establish a therapeutic alliance in record time. It is able to tolerate a certain degree of uncertainty, manage and tolerate the level of risk. He stands out for being flexible and dynamic in order to be able to adapt to the patients and theirs circumstances. This requires empathy, closeness and commitment. Disclosure No significant relationships.
Published: 2022
Full Text: View/download PDF

39. Deep dyslexia in a Dutch-speaking patient

Author: Paul M. Parizel, H. R. Van Dongen, P Van Vugt, J.J. Martin, P Bal, Philippe Paquier, and W L Creten
Subjects: Linguistics and Language, media_common.quotation_subject, Average intelligence, LPN and LVN, medicine.disease, Language and Linguistics, Developmental psychology, Neurology, Otorhinolaryngology, Reading (process), Deep dyslexia, Developmental and Educational Psychology, medicine, Neurology (clinical), Situational ethics, Psychology, media_common
Abstract: A left-handed, Dutch-speaking woman of average intelligence became aphasic after having sustained a left frontotemporal cerebrovascular accident. As she had made semantic paralexias while reading isolated words during a routine aphasiological assessment, we wanted to know whether she could be characterized as «deep dyslexic», and whether the deep dyslexia symptom complex described in English-speaking patients would recur in a Dutch-speaking patient. We subsequently administered two experimental reading tests in order to investigate the organization of five situational lexical-semantic categories, and to analyse the types of reading errors affecting different word classes. Our findings, which indicate that the patient is a deep dyslexic reader, shed light upon three theoretical issues: (1) the occurrence of individual differences within the symptom complex, (2) the plurimodality of certain features first thought to be specific to reading, and (3) the underlying causes of the semantic paralexias.
Published: 1992

40. Samarium-153-labelled EDTMP for bone metastases from cancer of the prostate

Author: T.F. Sandeman, R.S. Budd, and J.J. Martin
Subjects: Male, Palliative care, Pain, Bone Neoplasms, chemistry.chemical_compound, Organophosphorus Compounds, Bone Marrow, Prostate, Organometallic Compounds, medicine, Humans, Radiology, Nuclear Medicine and imaging, Radionuclide Imaging, Survival rate, Aged, Aged, 80 and over, Radioisotopes, Samarium, EDTMP, business.industry, Carcinoma, Palliative Care, Remission Induction, Prostatic Neoplasms, Cancer, Radiotherapy Dosage, Middle Aged, medicine.disease, Thrombocytopenia, Survival Rate, medicine.anatomical_structure, Oncology, chemistry, Radionuclide therapy, Bone marrow, business, Nuclear medicine, Cancellous bone
Abstract: A Phase I dose-escalation trial of a bone seeking phosphonate labelled with Samarium-153 was conducted on heavily pretreated patients with widespread bony metastases from cancer of the prostate. The bone marrow dose was calculated initially on a 4:1 uptake of cortical to cancellous bone, but subsequent information suggested the distribution was approximately equal so that the marrow received about three times the dose that has been prescribed. As a result, what were at first thought to be doses of 0.5 Gy, 1.0 Gy and 1.5 Gy were probably 1.5 Gy, 3.0 Gy and 4.5 Gy respectively. Three patients were treated at each dose level. The dose was repeated in the first three. Pain relief was delayed for 2 weeks, and was maximal by 4 weeks. All but one patient gained some benefit but this was transitory, lasting only 4-6 weeks in most. A recalculated dose of 3 Gy proved the most effective. The major toxicity was to platelets. Thrombocytopenia was fatal in four cases (two with repeat doses). All patients died but three survived more than 6 months with the help of third line hormonal measures and local radiotherapy to maintain comfort. A second group of five patients, not previously irradiated, were given 153Sm-EDTMP to a marrow dose of 3 Gy and all have survived for more than 4 months and achieved minimal to excellent relief of pain. The technique is recommended as initial therapy in unirradiated patients with good bone marrow function and with significant pain above and below the diaphragm, making half-body irradiation less likely to be a useful palliative procedure.
Published: 1992

41. Immunohistochemical analysis of the oxidative phosphorylation complexes in skeletal muscle from patients with mitochondrial DNA encoded tRNA gene defects

Author: B. De Paepe, Martin Lammens, L. De Meirleir, Sara Seneca, Joél Smet, J.J. Martin, Willy Lissens, J. De Bleecker, R. Van Coster, Department of Embryology and Genetics, and Pediatrics
Subjects: Adult, Male, Pathology, medicine.medical_specialty, Mitochondrial DNA, Respiratory chain, mitochondrial DNA, Biology, Stain, DNA, Mitochondrial, Oxidative Phosphorylation, Pathology and Forensic Medicine, Immunoenzyme Techniques, Mitochondrial myopathy, RNA, Transfer, Multienzyme Complexes, medicine, Perception and Action [DCN 1], Humans, Muscle, Skeletal, mitochondrial diseases, mtDNA, immunohistochemical analysis, Skeletal muscle, Infant, Mitochondrial Myopathies, General Medicine, Middle Aged, medicine.disease, Molecular biology, Heteroplasmy, Staining, medicine.anatomical_structure, Mitochondrial medicine [IGMD 8], Lactic acidosis, Mutation, Electrophoresis, Polyacrylamide Gel, Female, OXPHOS complexes, Human medicine, tRNA gene defect, Biomarkers
Abstract: Item does not contain fulltext BACKGROUND: Mitochondrial diseases display a heterogeneous spectrum of clinical phenotypes and therefore the identification of the underlying gene defect is often a difficult task. AIMS: To develop an immunohistochemical approach to stain skeletal muscle for the five multi-protein complexes that organise the oxidative phosphorylation (OXPHOS) in order to improve the diagnostic workup of mitochondrial defects. METHODS: OXPHOS complexes were visualised in skeletal muscle tissue using antibodies directed against different subunits. The staining patterns of patients with heteroplasmic defects in mtDNA tRNA genes were compared with those of normal and disease controls. RESULTS: Normal skeletal muscle displayed a checkerboard staining pattern for complexes I to V due to the higher mitochondrial content of slow muscle fibres versus fast fibres. In patients with tRNA defects, a much more heterogeneous staining pattern was observed for complex I (all six patients) and complex IV (4 of 6 patients): a mosaic staining pattern in which individual fibres displayed staining intensities that ranged from strong to negative. Ragged red fibres (RRFs) in patients with MERRF (myoclonic epilepsy and ragged red fibres) were all complex I and IV negative, while in patient with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes) the majority of RRFs were complex I negative and complex IV positive. CONCLUSION: Immunohistochemical detection of OXPHOS complexes could represent a valuable additional diagnostic tool for the evaluation of mitochondrial cytopathy. The technique helps to detect heteroplasmic mtDNA defects. Staining for complex I in particular was able to identify two tRNA patients that stayed undetected with routine histochemical evaluation.
Published: 2009

42. Evidence for Allelic Heterogeneity in Familial Early-Onset Alzheimer's Disease

Author: J.J. Martin, John Hardy, Alison Goate, Martin N. Rossor, C. Van Broeckhoven, A. Hofman, Antoon Vandenberghe, C M van Duijn, and Michael Mullan
Subjects: Genetic Markers, Chromosomes, Human, Pair 21, Genetic Linkage, Genetic counseling, Population, Chromosome Disorders, Locus (genetics), Biology, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Risk Factors, Genetic linkage, medicine, Humans, Early-onset Alzheimer's disease, 030212 general & internal medicine, Allele, education, Alleles, Aged, Genes, Dominant, Chromosome Aberrations, Genetics, education.field_of_study, Models, Genetic, Genetic Carrier Screening, Middle Aged, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Allelic heterogeneity, Age of onset
Abstract: Age of onset was examined for 139 members of 30 families affected by early-onset AD. Most (77%) of the variance of age of onset derived from differences between rather than within families. The constancy of age of onset within families was also observed in an analysis restricted to families derived from a population-based epidemiological study with complete ascertainment of early-onset AD. Furthermore, we observed clustering of age of onset within those families that support linkage to the predisposing locus on chromosome 21. Our data are compatible with the view that allelic heterogeneity at the AD locus may account for the similarity in age of onset within families. This finding may be of value for scientific studies of AD as well as for genetic counselling.
Published: 1991

43. A new affinity adsorbent for the purification of phospholipases A1 and A2 from animal venoms

Author: Enrique Reynaud, J. Vargas-Villarreal, Alejandro Alagón, and J.J. Martin-Polo
Subjects: Wasp Venoms, Phospholipase, Ligands, Toxicology, Chromatography, Affinity, Phospholipases A, chemistry.chemical_compound, Phospholipase A2, Phospholipase A1, Affinity chromatography, Crotalid Venoms, Stearates, Crotalus adamanteus, Animals, Carbodiimide, Phospholipase A, Chromatography, biology, Venoms, Sepharose, Lizards, biology.organism_classification, Phospholipases A1, Phospholipases A2, chemistry, biology.protein, Electrophoresis, Polyacrylamide Gel
Abstract: Dimethyl-DL-2,3-distearoyloxy-propyl-2'-hydroxy-ethylammonium++ + (Rosenthal's inhibitor) was coupled to carboxyhexyl-Sepharose 4B, through carbodiimide chemistry. Phospholipase A2 from Heloderma horridum horridum and Crotalus adamanteus bind to the immobilized ligand in the presence of Ca2+ and can be easily eluted under acidic conditions or in the presence of a chelating agent, respectively. This affinity media proved to be effective also in the purification of a Ca2(+)-independent phospholipase A1 from vespid venom.
Published: 1991

44. Radiation‐induced frequency offsets and acoustic loss in AT‐cut quartz crystals

Author: J.J. Martin
Subjects: Hydrogen, business.industry, Relaxation (NMR), General Physics and Astronomy, chemistry.chemical_element, Radiation, Molecular physics, Crystallographic defect, Ionizing radiation, Optics, chemistry, Ionization, business, Elastic modulus, Quartz
Abstract: Ionizing radiation and sweeping modify the defects present in quartz. According to relaxation theory the modification should produce a fractional frequency offset, Δf/f, equal to the negative of the sum of the changes in strength of the acoustic loss peaks with peak temperatures below the turnover. We have measured the acoustic loss and frequency versus temperature curves as functions of radiation dose, and alkali and hydrogen sweeping for AT‐cut cultured quartz crystals with widely varying aluminum concentrations. The largest offsets were observed for the Na‐swept crystals and the smallest for the H‐swept samples. In addition, the smallest radiation‐induced offsets were found in swept crystals with the lowest Al content. The magnitude of Δf/f was different from that predicted by relaxation theory. Instead, the observed Δf/f at the turnover consisted of: (1) the expected relaxation component, (2) a Δf/f at low temperatures in all samples studied, and (3) a change in the overall f(T) curve which appears only in Na‐swept crystals. The low T offset is caused by T‐independent changes in the elastic modulus. These must be due to the modifications of the interatomic forces brought about by the radiation‐induced defect changes. Our general findings support the use of swept low‐aluminum quartz in radiation environments.
Published: 1990

45. Infantile presentation of the mitochondrial A8344G mutation

Author: J.J. Martin, F. Pierart, Sara Seneca, Emmanuel Scalais, O. Battisti, R. Van Coster, Willy Lissens, Christian Nuttin, B. De Paepe, René Stevens, L. De Meirleir, Joél Smet, Department of Embryology and Genetics, and Pediatrics
Subjects: Pathology, medicine.medical_specialty, business.industry, abnormal breathing pattern, systemic hypertension, Oxidative phosphorylation, Bioinformatics, Leigh syndrome, MERRF, Neurology, Mutation (genetic algorithm), medicine, Neurology (clinical), Presentation (obstetrics), business, brainstem lesions
Abstract: no abstract
Published: 2007

46. P.3.8 Laing early-onset distal myopathy in a Belgian family

Author: P. Van den Bergh, E. Schmedding, Emile-Christian Laterre, J.J. Martin, Frédéric Lecouvet, Ingeborg Liebaers, and Michel Fardeau
Subjects: medicine.medical_specialty, Foot drop, Weakness, business.industry, Anatomy, medicine.disease, Surgery, Atrophy, Neurology, Pediatrics, Perinatology and Child Health, medicine, Paralysis, MYH7, Neurology (clinical), medicine.symptom, Family history, Iliopsoas, Myopathy, business, Genetics (clinical)
Abstract: Laing early-onset distal myopathy (MPD1) is a very rare autosomal dominant disorder due to mutations in the MYH7 gene, which encodes the slow beta-myosin heavy chain. Only a few families have been reported from Australia, Austria, Finland, France, Germany, Italy, Moldova, the Netherlands, Norway, and Spain. We report the first family from Belgium. The proposita started limping with the right leg at age 7. At age 14, right hand weakness was noted with difficulty grasping and writing. At age 24, foot drop right > left, right Achilles tendon contracture, and areflexia were noted. At age 54, the patient began to use a wheelchair. There was paralysis of the deltoid, iliopsoas, and finger and foot extensor muscles and marked weakness of neck flexor and other muscles. The proposita’s daughter is an only child. At age 4, weakness of foot extensor muscles and areflexia were noted. At age 15, hand muscle strength began to decrease. At age 25, muscle testing showed severe weakness of the finger, toe, and foot extensor muscles and mild weakness of the neck flexor and proximal muscles. At age 38, the patient is still walks short distances. In both patients, CK and nerve conductions were normal, but EMG showed a BSAPP pattern in distal muscles. Heart and respiration were normal. Several muscle biopsies have been performed in each with diagnoses of aspecific myopathic changes, type 1 fibre predominance, type 1 fibre atrophy, congenital fibre type disproportion, denervation-reinnervation. For decades, a diagnosis of distal SMA has been entertained based on the muscle pathology. Analysis of MYH7 revealed a c.4522_4524del mutation (p.Glu1508del). As there is no family history, this appears to be a de novo mutation, which has been reported in a French and a Norwegian family and in a sporadic Finnish patient.
Published: 2013

47. POLG mutations in neurodegenerative disorders with ataxia but no muscle involvement

Author: A Al Memar, Anu Suomalainen, Petri Luoma, Maria Rantamäki, Seppo Kaakkola, G. Van Goethem, Peter Hackman, C. Van Broeckhoven, Bjarne Udd, J.J. Martin, Ann Löfgren, Ralf Krahe, and P. De Jonghe
Subjects: Adult, Male, Mitochondrial DNA, Pathology, medicine.medical_specialty, Ophthalmoplegia, Chronic Progressive External, Ataxia, Adolescent, Mitochondrial disease, Mutation, Missense, DNA-Directed DNA Polymerase, Biology, Compound heterozygosity, DNA, Mitochondrial, 03 medical and health sciences, 0302 clinical medicine, Sensory ataxia, medicine, Humans, Point Mutation, Cognitive decline, Myopathy, 030304 developmental biology, Aged, 0303 health sciences, Muscles, Brain, Neurodegenerative Diseases, Middle Aged, medicine.disease, 3. Good health, DNA Polymerase gamma, Pedigree, Mutation, Female, Neurology (clinical), medicine.symptom, Myoclonus, 030217 neurology & neurosurgery
Abstract: Objective: To identify POLG mutations in patients with sensory ataxia and CNS features. Methods: The authors characterized clinical, laboratory, and molecular genetic features in eight patients from five European families. The authors conducted sequencing of coding exons of POLG, C10orf2 (Twinkle), and ANT1 and analyzed muscle mitochondrial DNA (mtDNA), including Southern blot analysis and long-range PCR. Results: Ataxia occurred in combination with various CNS features, including myoclonus, epilepsy, cognitive decline, nystagmus, dysarthria, thalamic and cerebellar white matter lesions on MRI, and neuronal loss in discrete gray nuclei on autopsy. Gastrointestinal dysmotility, weight loss, cardiomyopathy, and valproate-induced hepatotoxicity occurred less frequently. Two patients died without preceding signs of progressive external ophthalmoplegia. In muscle, typical findings of mitochondrial disease, such as ragged red fibers and Southern blot mtDNA abnormalities, were absent. POLG mutations were present in eight patients, including two isolated cases, and one Finnish and two unrelated Belgian families contained in total six patients. All POLG mutations were recessive, occurring in a homozygous state in seven patients and in a compound heterozygous state in one patient. The novel W748S mutation was identified in five patients from three unrelated families. Conclusions: The clinical spectrum of recessive POLG mutations is expanded by sensory ataxic neuropathy, combined with variable features of involvement of CNS and other organs. Progressive external ophthalmoplegia, myopathy, ragged red fibers, and Southern blot abnormalities of muscle mitochondrial DNA also are not mandatory features associated with POLG mutations.
Published: 2004

48. Spinocerebellar ataxia type 7 associated with pigmentary retinal dystrophy

Author: C. Van Broeckhoven, J.J. Martin, and Andrej Michalik
Subjects: Retinal degeneration, Male, Ataxin 7, Context (language use), Nerve Tissue Proteins, Biology, Pathogenesis, Trinucleotide Repeats, Retinitis pigmentosa, Genetics, medicine, Humans, Spinocerebellar Ataxias, Age of Onset, Genetics (clinical), Ataxin-7, Inclusion Bodies, Retinal Degeneration, Polyglutamine tract, medicine.disease, Pedigree, Disease Models, Animal, Spinocerebellar ataxia, biology.protein, Female, Trinucleotide repeat expansion, Peptides
Abstract: Spinocerebellar ataxia type 7 (SCA7) is an autosomal-dominant, late-onset, slowly progressive disorder, primarily characterized by gradual loss of motor coordination, resulting from dysfunction and degeneration of the cerebellum and its connecting pathways. The disease is caused by expansion of a CAG trinucleotide repeat within the SCA7 gene, which encodes a polyglutamine tract within a novel protein, termed ataxin-7. The expansion of polyglutamine-encoding CAG repeats in dissimilar genes underlies eight neurodegenerative conditions besides SCA7, including a number of dominant ataxias related to SCA7. Although elongated polyglutamine itself can initiate neuronal dysfunction and death, its toxicity is modulated by the context of the disease proteins, as evidenced by the differing clinical and pathological presentation of the various disorders. In this respect, it is exciting that SCA7 constitutes the only polyglutamine disorder, in which the photoreceptors of the retina are also severely affected, leading to retinal degeneration and blindness. Since the discovery of the SCA7 mutation, numerous studies attempted to pinpoint the molecular mechanisms underlying the unique features of SCA7, particularly the retinal involvement. Here we summarize the clinical, pathological, and genetic aspects of SCA7, and review the current understanding of the pathogenesis of this disorder.
Published: 2003

49. The growth of high quality quartz in heavy water

Author: J.J. Martin, D.F. Croxall, Marguerita McGovern, and A.L. Haston
Subjects: inorganic chemicals, Heavy water, Hydrogen, technology, industry, and agriculture, Analytical chemistry, Infrared spectroscopy, chemistry.chemical_element, Alkali metal, complex mixtures, Crystal, chemistry.chemical_compound, Deuterium, chemistry, Sodium carbonate, Quartz
Abstract: Hydrogen and alkali ions introduced by the growth environment are the main interstitial impurities found in cultured quartz. As-grown cultured quartz has a set of "growth-defects" which trap hydrogen and cause four OH infrared bands (GD-OH). Their room-temperature infrared absorption is commonly used to grade cultured quartz. The aluminum concentration and, consequently, the alkali concentration can be reduced to a very low level by careful growth from high-purity nutrient A quartz growth programme using D/sub 2/O was planned to produce a stock of high quality quartz for basic studies in which the hydrogen had been replaced by deuterium. We report the growth of high purity quartz using a sodium carbonate mineraliser dissolved in 99.9% purity D/sub 2/O. Dislocation densities of about 1/cm were achieved in all runs by using Z-cut seeds derived from the fast-X sector of a large synthetic crystal. Chemical analysis gave typical aluminum concentrations of 0.03 /spl mu/mole/mole. Low-temperature FTIR spectra were taken on Z-cut test samples in the as-grown condition and after being swept in hydrogen. Only the deuterium versions of the four GD-OH bands were present in the as-grown samples. The GD-OD concentration of about 0.8 /spl mu/mole/mole was found for the final slow growth samples.
Published: 2003

50. Integrated software support for a course on computer organization and assembly language

Author: J.J. Martin
Subjects: Assembly language, Computer science, business.industry, Integrated software, computer.software_genre, Course (navigation), Virtual machine, Teaching tool, ComputingMilieux_COMPUTERSANDEDUCATION, Software engineering, business, Computer aided instruction, computer, Machine code, Curriculum, computer.programming_language
Abstract: Curricula in computer engineering and computer science usually offer a mandatory course in machine and assembly language. This paper describes an integrated teaching tool for such a course, and classroom experience with using it. The tool consists of trainers for number systems and conversions, a simulator for a simple processor, an assembler for this processor, and a linker. Teaching experience has now been accumulated over six semesters. The material covered and the depth of knowledge acquired by students significantly exceeded the level reached when a commercial assembler was used.
Published: 2003

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Category

Publication Type

Journal

Database

Publisher

163 results on '"J.J. Martin"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources