1. The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology
- Author
-
Chang-Yub Kim, Andrew W. Munro, E. De Rossi, Anthony R.M. Coates, Tom Alber, Ehmke Pohl, H.-J Yoon, Byung Il Lee, M.M Komen, Geoffrey S. Waldo, Gianluca Fossati, Celia W. Goulding, J.S. Lott, Menico Rizzi, Alun R. Coker, J.E Kwak, Marco Bellinzoni, Edward N. Baker, Paolo Mascagni, William R. Jacobs, Michael M. Roberts, V Lamzin, Matthias Wilmanns, M.G Lee, S.-H Baek, Steve P. Wood, Shekhar C. Mande, Marcin I. Apostol, M.S Park, Ker R. Marshall, Clare V. Smith, Roberto T. Bossi, Bernhard Rupp, Giovanna Riccardi, David Leys, Wolfram Meyer-Klaucke, Vickery L. Arcus, Andrea Mattevi, Christos Colovos, Se Won Suh, David Eisenberg, Anna Milano, Kirsty J. McLean, James C. Sacchettini, Jiyeon Lee, Daniel H. Anderson, Bhupesh Taneja, Joel Berendzen, J.K Yang, Thomas C. Terwilliger, Harindarpal S. Gill, Paul A. Tucker, Li-Wei Hung, Byung Woo Han, Los Alamos National Laboratory (LANL), Texas A&M University [College Station], Università degli Studi di Pavia, St George's Hospital Medical School [London], University of Southampton, Howard Hughes Medical Institute (HHMI), University of California [Los Angeles] (UCLA), University of California, Centre for DNA Fingerprinting and Diagnostics [Hyderabad] (CDFD), European Molecular Biology Laboratory [Hamburg] (EMBL), University of Leicester, Seoul National University [Seoul] (SNU), University of Auckland [Auckland], Yeshiva University, NY, University of California [Berkeley], Lawrence Livermore National Laboratory (LLNL), and Work from the laboratory of Se Won Suh was supported by the Korea Ministry of Science and Technology (NRL-2001, grant no. M1-0104000132-01J000006210). Work from the laboratory of University of Pavia was supported by the Italian Ministry of University and Scientific and Technological Research (MURST, grant COFIN-1998, COFIN-2002) and by the European Union research project Quality of Life and Management of Living Resources (Contract No. QLK2-2000-01761). Work from many of the laboratories was supported by the NIH. The UCLA authors wish to acknowledge Mari Gingery, Duilio Cascio, Michael Sawaya and Cameron Mura for useful suggestions and discussion. The UCLA work has been supported by grants from the Department of Energy and the National Institutes of Health.
- Subjects
MESH: Mycobacterium tuberculosis ,Protein Conformation ,International Cooperation ,MESH: Amino Acid Sequence ,MESH: Genome, Bacterial ,Resource (project management) ,MESH: Protein Conformation ,MESH: Bacterial Proteins ,0303 health sciences ,Protein function ,Drug discovery ,MESH: Genomics ,Genomics ,3. Good health ,[SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM] ,Infectious Diseases ,Microbiology (medical) ,Mycobacterium Tuberculosis Structural Genomics Consortium ,Tuberculosis ,Extracellular proteins ,[PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph] ,Immunology ,Molecular Sequence Data ,Structural genomics ,MESH: Sequence Alignment ,Computational biology ,[SDV.BC]Life Sciences [q-bio]/Cellular Biology ,Biology ,Microbiology ,Mycobacterium tuberculosis ,03 medical and health sciences ,Bacterial Proteins ,medicine ,[CHIM.CRIS]Chemical Sciences/Cristallography ,Humans ,[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology ,Amino Acid Sequence ,030304 developmental biology ,X-ray crystallography ,MESH: Humans ,MESH: Molecular Sequence Data ,030306 microbiology ,business.industry ,NAD synthetase ,medicine.disease ,biology.organism_classification ,Biotechnology ,MESH: International Cooperation ,Protein structure ,[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] ,business ,Sequence Alignment ,Genome, Bacterial - Abstract
International audience; The TB Structural Genomics Consortium is an organization devoted to encouraging, coordinating, and facilitating the determination and analysis of structures of proteins from Mycobacterium tuberculosis. The Consortium members hope to work together with other M. tuberculosis researchers to identify M. tuberculosis proteins for which structural information could provide important biological information, to analyze and interpret structures of M. tuberculosis proteins, and to work collaboratively to test ideas about M. tuberculosis protein function that are suggested by structure or related to structural information. This review describes the TB Structural Genomics Consortium and some of the proteins for which the Consortium is in the progress of determining three-dimensional structures.
- Published
- 2003
- Full Text
- View/download PDF