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As a basic form of behavioral plasticity, habituation enables organisms to adjust their behaviors in response to external stimulation and is a fundamental ability of organisms. The emulation of habituation in hardware becomes critical in highly efficient artificial neuromorphic computing. However, few devices can mimic habituation because it includes two opposite responses to the same repeated stimulus. Herein, we fabricate a device of Au/LiTaO3/Pt, which not only shows synaptic plasticity, such as long-term potentiation/depression and paired-pulse facilitation, but also demonstrates habituation behavior. In addition, the habituation characteristics, which is dependent on the intensity and frequency of stimulus, are realized on the device. The analysis of electrical transport behavior indicates that the variation in resistance states correlates with the injection/extraction of free carriers during the resistance switching and suggests that the habituation behavior originates from the evolution of conductive domain walls in LiTaO3 ferroelectric.

Bulk Bi0.5Sr0.5Fe0.5Cr0.5O3 (BSFCO) is a new compound comprising the R3c structure. The structural, magnetic property and exchange bias (EB) details are investigated. The material was in the super-paramagnetic (SP) state at room temperature. Exchange bias usually occurs at the boundary between different magnetic states after field cooling (HFC) acts on the sample. Here the result shows that changing HFC from 1 to 6 T reduces the HEB value by 16% at 2 K at the same time. Meanwhile, HEB diminishes as the ferromagnetic layer thickness increases. The variation of (the thickness of ferromagnetic layer) tFM with the change of HFC leads to the tuning of HEB by HFC in BSFCO bulk. These effects are obviously different from the phenomenon seen in other oxide types.

This paper reports the improvement of electrical, ferroelectric and endurance of Hf0.5Zr0.5O2 (HZO) thin-film capacitors by implementing W electrode. The W/HZO/W capacitor shows excellent pristine 2Pr values of 45.1 μC/cm2 at ±6 V, which are much higher than those of TiN/HZO/W (34.4 μC/cm2) and W/HZO/TiN (26.9 μC/cm2) capacitors. Notably, the maximum initial 2Pr value of W/HZO/W capacitor can reach as high as 57.9 μC/cm2 at ±7.5 V. These strong ferroelectric polarization effects are ascribed to the W electrode with a fairly low thermal expansion coefficient which provides a larger in-plane tensile strain compared with TiN electrode, allowing for enhancement of o-phase formation. Moreover, the W/HZO/W capacitor also exhibits higher endurance, smaller wake-up effect (10.1%) and superior fatigue properties up to 1.5 × 1010cycles compared to the TiN/HZO/W and W/HZO/TiN capacitors. Such improvements of W/HZO/W capacitor are mainly due to the decreased leakage current by more than an order of magnitude compared to the W/HZO/TiN capacitor. These results demonstrate that capping electrode material plays an important role in the enhancement of o-phase formation, reduces oxygen vacancies, mitigates wake-up effect and improves reliability.

Synthetic aperture radar (SAR) can be applied to observe the sea surface and detect ship targets. Images obtained by SAR can be hard to read because of the denseness of ships, extremely unbalanced foreground-background, and small target size. The existing objective detection approaches achieve superior performance by sacrificing detection speed and flexibility on computational resource due to redundant model parameters. These features happens to be extremely crucial for SAR ship detection in real-time scenarios. To effectively tradeoff the issue on both time and space complexity, we propose a novel objective detection method tailored for SAR ship detection problem. We examine the effectiveness of our method on two open datasets: high resolution SAR images dataset (HRSID) and large-scale SAR ship detection dataset-v1.0 (LS-SSDD-V1.0). The results show better performance over the state-of-the-art You Only Look Once version 4 (YOLOv4) framework in terms of accuracy, efficiency, and model complexity.

Searching for low-power-consuming and high-efficient methods for well controllable driving of skyrmion motion is one of the most concerned issues for future spintronic applications, raising high concern with an appreciated choice of magnetic media and driving scenario. In this work, we propose a novel scenario of spin wave driven skyrmion motion in a ferrimagnetic (FiM) lattice with the net angular momentum {\delta}s. We investigate theoretically the effect of both {\delta}s and the circular polarization of spin wave on the skyrmion dynamics. It is revealed that the momentum onto the skyrmion imposed by the excited spin wave can be partitioned into a ferromagnetic term plus an antiferromagnetic term. The ratio of these two terms and consequently the Hall angle of skyrmion motion can be formulated as the functions of {\delta}s, demonstrating the key role of {\delta}s as an effective control-parameter for the skyrmion motion. Moreover, the spin wave frequency dependent skyrmion motion is discussed, predicting the frequency enhanced skyrmion Hall motion. This work thus represents an essential contribution to understand the skyrmion dynamics in a FiM lattice., Comment: 25 pages, 4 figures

STUDY QUESTION What is the true incidence of chromosomal mosaicism in embryos analyzed by preimplantation genetic testing (PGT) SUMMARY ANSWER The true incidence of chromosomal mosaicism is much lower than we usually surmise. WHAT IS KNOWN ALREADY In recent years, contemporary methods for chromosome analysis, along with the biopsy of more than one cell, have given rise to an increased rate of chromosomal mosaicism detection after preimplantation genetic testing for aneuploidy. However, the exorbitant incidence of mosaicism represents a dilemma and imposes restrictions on the application of PGT treatment. Concern has been raised about the possibility that the incidence of chromosomal mosaicism is overestimated and quite a few of the results are false-positive errors. However, studies verifying the diagnosis of chromosomal mosaicism and assessing the true incidence of chromosomal mosaicism are limited. STUDY DESIGN, SIZE, DURATION A total of 1719 blastocysts from 380 patients who underwent PGT treatment were retrospectively analyzed to evaluate the typical incidence of mosaicism. Then 101 embryos donated by 70 couples were re-biopsied and dissected into three portions if available: trophectoderm (TE), inner cell mass (ICM), and the remaining portions. All the portions were tested using next-generation sequencing (NGS), and the results were compared to the original diagnosis. PARTICIPANTS/MATERIALS, SETTING, METHODS The setting for this study was a university-affiliated center with an in-house PGT laboratory. All samples were amplified with multiple annealing and looping-based amplification cycles (MALBACs) and the NGS was carried out on a Life Technologies Ion Proton platform. MAIN RESULTS AND THE ROLE OF CHANCE A clinical TE biopsy revealed an incidence of 11.9% for diploid-aneuploid mosaicism (DAM), 17.3% for aneuploid mosaicism (AM) and 29.1% in total. After rebiopsy, 94.1% whole-chromosome aneuploidies and 82.8% segmental-chromosome aneuploidies were confirmed in the embryos. As for the mosaic errors, only 32 (31.7%) out of 101 embryos presented with uniform chromosomal aberrations in agreement with the original biopsy results, 15 (14.8%) embryos presented with de novo chromosomal aberrations, and 54 (53.5%) embryos showed a euploid profile in all portions. Among the 32 uniform embryos, the true mosaicism was confirmed in only 4 cases, where a reciprocal chromosomal aberration was identified; 14 embryos presented with identical mosaicism, providing the moderate evidence for true mosaicism; and 14 embryos displayed uniform full aneuploidies in all portions of embryo, revealing a high-grade mosaicism or a false-negative diagnosis. Logistical regression analysis revealed that the concordance rate with ICM was associated with the type and level of mosaicism. The concordance rate of segmental-chromosome mosaicism was significantly lower than whole-chromosome mosaicism (adjusted Odds Ratio (aOR): 5.137 (1.061, 24.876), P = 0.042) and compared to DAM, the concordance rate of AM was significantly higher (aOR: 6.546 (1.354, 31.655), P = 0.019). The concordance rate also increased with increasing levels of mosaicism (P LIMITATIONS, REASONS FOR CAUTION This study was limited by a small sample size and the use of a single whole-genome amplification (WGA) method and NGS platform. These findings are only applicable to samples subjected to MALBAC amplification and Ion Proton platform, and studies involving larger sample sizes and multiple WGA methods and NGS platforms are required to prove our findings. WIDER IMPLICATIONS OF THE FINDINGS TE biopsy is reliable to detect whole-chromosome aneuploidies, but the ability to diagnose mosaicism is doubtful. More attention should be paid to false-positive and false-negative errors in NGS-based PGT, especially for laboratories using less stringent criteria for mosaicism classification (i.e. 20–80%), which might be subject to a much higher false-positive mosaicism rate in the practice. STUDY FUNDING/COMPETING INTEREST(S) This study was supported by grants from the National Key R&D Program of China (No. 2016YFC1000206-5) and the National Natural Science Foundation of China (No. 81701509) TRIAL REGISTRATION NUMBER N/A.

Although the dynamics of domain growth has been a long-standing topic in ferroic systems, its science complexity and important guidance to practical applications cannot be overemphasized. Highly anisotropic systems with only domain-wall-type defects and roughly isotropic systems with only vortex-type defects have been extensively studied as two ideal and extreme examples in terms of domain growth dynamics. The domain growth processes in these two types of systems are believed to follow two different scaling laws. The driving forces behind are domain wall motion and vortex–antivortex annihilation, respectively. However, no realistic ferroic systems have ever been found to exhibit a domain growth process that strictly follows these scaling laws. Fortunately, we now have a realistic ferroic system, i.e., the ferroelectric hexagonal manganite family in which the aforementioned two types of defects coexist. This system supports a fascinating topological vortex–antivortex domain structure and is a unique platform for probing a generalized theory on the domain growth dynamics that covers the two extremes. In this work, we investigate this vortex–antivortex domain structure and its growth dynamics within the framework of the Landau theory using phase-field simulations. It is revealed that morphology of this domain structure can be controlled by a correlation length Lc that is different from the conventional correlation length. More importantly, this domain structure can be seen as an intermediate state between the two extremes in terms of domain growth dynamics. When Lc is very small, the domain growth process in this domain structure is driven by domain wall motion and follows the well-known Allen–Cahn scaling law. As Lc increases, vortex–antivortex annihilation will dominate the domain growth process and the scaling law will need a logarithmical correction. The present work provides a comprehensive understanding of the domain growth behavior in such a realistic ferroic system of much attention and represents a substantial extension of domain growth dynamics toward complicated multi-defect systems.

Combining with the practical engineering case, this paper decomposed and analyzed the process of electronic products’ reliability assessment based on the Physics of Failure (PoF) method. The first step is to build a digital prototype model and then a PoF model. The second step is to use the Monte Carlo sampling method to obtain the failure samples of different fault points based on the PoF model. The third step is forming the failure DFs by fitting the failure samples. The fourth step is using the failure DF to calculate the Time to Failure (TTF)of the components. Finally, the paper can obtain the time of the TTF and the failure DF by applying the competitive failure principle. Compared with the reliability evaluation method based on test data, the reliability evaluation method based on PoF is more economical and efficient.

Background: A phase 1 dose escalation study of TAA013, an antibody drug conjugate linking trastuzumab to a cytotoxic small molecule, DM1, through an SMCC linker, in previously treated recurrent Her2 positive breast cancer patients. Material and Methods: This phase I study follows the traditional 3+3 design, dosing started at 0.6mg/kg, followed by 1.2, 2.4, 3.6, 4.8mg/kg, one intravenous infusion was given every 3 weeks, the initial infusion had to be over 90 minutes, infusion times were later shortened if treatment was well tolerated. The subsequent recommended dose would be expanded to include at least 10 patients. Patients were observed for dose-limiting toxicity (DLT) during a 21-day DLT observation period. Toxicities were graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events v5.0. Maximum-tolerated dose (MTD) was defined as the highest dose level that resulted in a DLT in no more than 1 of 6 patients. Study endpoints included safety and tolerability, pharmacokinetic and immunogenicity parameter evaluation, with preliminary evaluation of efficacy. Results: The study enrolled 22 female patients with histologically confirmed Her-2 positive metastatic breast cancer, median age of 50yrs (25-67), median time from initial diagnosis to TAA013 dosing was 39 months (5-99), median prior treatment regimen was 4 (2-10), all had received trastuzumab for a mean of 8.2 months (2-10), alone or in combination with chemotherapy, other prior Her2 targeting drugs given included pertuzumab (2), lapatinib (7), and pyrotinib (8). All patients received at least 2 (median of 6 infusions, range of 1-15) infusions, except for the last 4.8mg/kg patient, but all patients passed the dose limiting toxicity (DLT) observation period of 21 days. There were no dose limiting toxicities, no serious adverse events, nor that resulting in mortality, the maximum tolerated dose was not reached. The most common treatment emergent adverse events (TEAE) included 9 (40.9%) grade 1-2 infusion reactions associated with fever(5) and/or chills(1), the reaction often abated in subsequent cycles. There were no grade 4 TEAE, but there were 3 grade 3 thrombocytopenia, one grade 3 neutropenia, and one grade 3 hyperbilirubinemia which all recovered for the patients to continue treatment, there was also one grade 3 dermatitis in a patient with a history of chronic dermatitis. Antibody drug antibodies were not detected emanating from the TAA013 therapy. Pharmacokinetic studies included evaluation of TAA013, trastuzumab and DM1. Preliminary efficacy evaluation in the 2.4-4.8mg/kg dosing group of heavily pretreated patients resulted in 2 partial responses, including patients who had previously received pyrotinib therapy. Conclusion: TAA013 is a Her2 targeting antibody drug conjugate that is safe and tolerable, with efficacy demonstrated in heavily pretreated Her2 positive breast cancer patients. Keywords: breast cancer, antibody drug conjugates, TAA013. Citation Format: J M Liu, Y M Yin, Hao Wu, W Li, X Huang, XX Li. TAA013 a trastuzumab antibody drug conjugate phase I dose escalation study in recurrent her2 positive breast cancer [abstract]. In: Proceedings of the 2020 San Antonio Breast Cancer Virtual Symposium; 2020 Dec 8-11; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2021;81(4 Suppl):Abstract nr PS10-51.

The effect of temperature on the impact characteristics of the ring chain under different working conditions was investigated with ABAQUS simulation, the curves were fitted with MATLAB, and the results were experimentally verified. The temperature has little effect on minimum steady-state stress. The friction energy dissipation has three polynomial temperature relations under heavy-load start-up, and its dissipation does not vary at fluctuating loads. Under two working conditions, the plastic energy dissipation and internal energy increase linearly with temperature; at abrupt load variations, those energies increase with the tendency to stabilization. This method is of great significance for improving the initial characteristics of a scraper conveyor, variable-load operations, and design optimization of the ring chain.

Background Colorectal cancer (CRC) has emerged as a major public health concern. However, little is known about the burden attributable to specific risk factors. The present study aimed to estimate the temporal trends and geographical variation of CRC burden attributable to a diet low in milk in China. Methods Following the general analytic strategy used in the 2017 Global Burden of Disease study, we assessed the age-, sex-, and province-specific mortality and disability-adjusted life-years (DALYs) of CRC caused by a diet low in milk in China from 1990 to 2017. Results In 2017, a diet low in milk contributed 32 032 [95% uncertainty interval (UI) = 11 350-53 806] deaths and 726 710 (95% UI = 256 651-1 218 153) DALYs for CRC with a population attributable fraction of 17.1%. The age-standardised mortality and DALY rates per 100 000 were 1.7 (95% UI = 0.6-2.9) and 36.8 (95% UI = 13.0-61.7), respectively. An upward trend with age in rates of mortality and DALYs was observed. Males had higher age-standardised rates than females. The number of deaths and DALYs increased significantly from 1990 to 2017, whereas the corresponding age-standardised rates showed relatively stable trends. In 2017, Hunan and Liaoning were ranked as the top two provinces in terms of disease burden. Socio-demographic index had a weak correlation with the age-standardised mortality (r = 0.348, P = 0.047). Conclusions The present study shows a substantial increase in the CRC burden attributable to a diet low in milk over the past three decades. Greater priority in CRC prevention should be given to males and the elderly population throughout China, particularly in less-developed provinces.

Flexible sensors have been widely investigated due to their broad application prospects in various flexible electronics. However, most of the presently studied flexible sensors are only suitable for working at room temperature, and their applications at high or low temperatures are still a big challenge. In this work, we present a multimodal flexible sensor based on functional oxide La0.7Sr0.3MnO3 (LSMO) thin film deposited on mica substrate. As a strain sensor, it shows excellent sensitivity to mechanical bending and high bending durability (up to 3600 cycles). Moreover, the LSMO/Mica sensor also shows a sensitive response to the magnetic field, implying its multimodal sensing ability. Most importantly, it can work in a wide temperature range from extreme low temperature down to 20 K to high temperature up to 773 K. The flexible sensor based on the flexible LSMO/mica hetero-structure shows great potential applications for flexible electronics using at extreme temperature environment in the future.

Magnetic skyrmions are magnetic textures with topological protection, which are expected to be information carriers in future spintronic devices. In this work, we propose a scheme to implement hybrid magnetic skyrmions (HMS) in ferrimagnets, and we study theoretically and numerically the dynamics of the HMS driven by spin-orbit torque. It is revealed that the skyrmion Hall effect depends on the skyrmion helicity and the net angular momentum ({\delta}s), allowing the effective modulation of the HMS motion through tuning Dzyaloshinskii-Moriya interaction and {\delta}s. Thus, the Hall effect can be suppressed through selecting suitable materials to better control the HMS motion. Moreover, Magnus force for finite {\delta}s suppresses the transverse motion and enhances the longitudinal propagation, resulting in the HMS dynamics in ferrimagnets faster than that in antiferromagnets., Comment: 25 pages, 6figures

The ferroelectricity of Hf0.5Zr0.5O2 (HZO) thin films has been usually reported to be induced by metallic capping layer. In this work, we successfully obtained ferroelectricity of HZO thin films induced by ultrathin insulating Al2O3 capping layers. The ferroelectric properties of HZO thin films induced by Al2O3 capping layers with different thickness have been investigated. It was found that the Al2O3(2 nm)/HZO (20 nm) stack shows excellent ferroelectric properties. The Au/Al2O3(2 nm)/HZO (20 nm)/TiN capacitor exhibits a very low leakage current of $\sim {4.2}\times {10}^{\text {-9}}$ A at 4 V and a maximum $2{P}_{r}\approx 32.3~\mu \text{C}$ /cm2 at sweeping voltages between ±8 V. In addition, the capacitor also shows excellent endurance properties up to 108 cycles. Our work demonstrated that dielectric films like Al2O3 can be adopted to be used as capping layer to generate excellent ferroelectric properties of HfO2-based thin films, which will contribute to their future applications in ferroelectric memory and negative capacitance transistors.

${\mathrm{Sr}}_{2}\mathrm{Ir}{\mathrm{O}}_{4}$ hosts a novel ${J}_{\mathrm{eff}\phantom{\rule{4pt}{0ex}}}=1/2$ Mott state and quasi-two-dimensional antiferromagnetic order, providing a unique avenue of exploring emergent states of matter and functions that are extraordinarily sensitive to any structural variations. Although the correlation between the physical property and the lattice structure in ${\mathrm{Sr}}_{2}\mathrm{Ir}{\mathrm{O}}_{4}$ has been a focused issue in the past decade, a common perception assumes that the magnetic ordering is essentially determined by the Ir-O-Ir bond angle. Therefore, a delicate modulation of this angle and, consequently, a major modulation of the magnetic ordering by chemical doping, such as Ga at the Ir site, has been extensively investigated and well believed. In this paper, however, we present a whole package of structure and magnetism data on a series of single-crystal and polycrystalline ${\mathrm{Sr}}_{2}{\mathrm{Ir}}_{1\ensuremath{-}x}{\mathrm{Ga}}_{x}{\mathrm{O}}_{4}$ samples, revealing the substantial difference in the N\'eel temperature ${T}_{N}$ between the two types of samples, and the ${T}_{N}$ value for the polycrystalline sample $x=0.09$ is even 64 K higher than that of the single-crystal sample $x=0.09$ ($\mathrm{\ensuremath{\Delta}}{T}_{\mathrm{N}}\ensuremath{\sim}64\phantom{\rule{0.16em}{0ex}}\mathrm{K}$ at $x=0.09$). Our systematic investigations demonstrate the crucial role of the c/a ratio in tuning the interlayer coupling and thereby the N\'eel point ${T}_{N}$, i.e., a higher ${T}_{N}$ can be achieved as c/a is reduced. The notable differences in structural parameters between the two groups of samples are probably caused by additional strain due to the massive grain boundaries in polycrystalline samples. The present paper suggests an additional ingredient of physics that is essential in modulating the emergent properties in ${\mathrm{Sr}}_{2}\mathrm{Ir}{\mathrm{O}}_{4}$ and probably other iridates.

Antiferromagnetic spintronics has been receiving attention recently, while spin-texture dependent magnetoresistance (MR) represents one of the main mechanisms for magnetic data storage. In particular, sufficiently large MR with high operating temperatures would be highly required for advanced spintronic applications. In this work, we experimentally investigate the MR effect of well-known antiferromagnet α-Fe2O3 (hematite) in a single crystal form, which has the Morin transition temperature as high as Tm ∼ 260 K. It is revealed that the MR effect associated with the spin-texture re-alignment, i.e., the spin-flop from the out-of-plane direction ( c axis) to the in-plane direction, driven by sufficiently low magnetic fields inclined along the [012] direction, reaches up to ∼2.5% at temperature T ∼ 250 K. The first-principles calculations suggest that this MR effect originates from the reduced bandgap due to the spin-flop and the finite spin–orbital coupling. The present work sheds light on the possibility of α-Fe2O3 as a favored MR-based candidate for near-room temperature spintronics.

OBJECTIVE: To describe the thyroid function abnormality of first-trimester twin pregnant women according to different references, and to explore its association with preterm delivery. METHODS: Participants, first-trimester twin pregnant women, were recruited at Peking University Third Hospital from March 2017 to February 2020. The thyroid hormone reference for ordinary adults identified on the assay kits by Siemens incorporation, thyroid hormone reference specifically for singleton pregnancy established previously, and thyroid hormone reference specifically for twin pregnancy established previously were used in the description of hypothyroidism and hyperthyroidism for first-trimester twin pregnant women. Thyroid autoantibody reference identified on the assay kits by Siemens incorporation was used in the description of positive thyroid autoantibody. Multivariable log-binomial regression was conducted to examine the association between thyroid function and preterm delivery, in which normal pregnant women according to the three references and normal pregnant women according to twin pregnancy reference accompanied with negative thyroid autoantibody were taken as control respectively. RESULTS: A total of 570 twin pregnant women were finally included. Rates of hypothyroidism according to the three references were 1.2%, 1.6% and 3.5%, respectively. Rates of hyperthyroidism according to the three references were 32.6%, 18.1% and 1.1%, respectively. After adjustment for potential confounding factors, risk of preterm delivery significantly increased in pregnant women with hyperthyroidism according to the twin specific pregnancy reference [adjusted relative risk (ARR)=1.41, 95%CI: 1.14-1.75], while no significant increase was found in those with normal thyroid function according to the twin specific pregnancy reference but hyperthyroidism according to the singleton specific pregnancy reference (ARR=1.00, 95%CI: 0.81-1.25) and in those with hyperthyroidism purely according to the ordinary adult reference (ARR=1.06, 95%CI: 0.85-1.32), compared with those normal according to all the references. Risks of preterm delivery almost significantly or significantly increased in pregnant women with hypothyroidism according to the ordinary adult or singleton specific pregnancy reference (ARR=1.40, 95%CI: 0.88-2.22) and those with hypothyroidism according to the twin specific pregnancy reference (ARR=1.53, 95%CI: 1.03-2.28). Overall analysis of thyroid function according to the twin specific pregnancy reference and thyroid autoantibody showed that risks of preterm delivery almost significantly or significantly increased in pregnant women with simple hypothyroidism (ARR=1.46, 95%CI: 0.93-2.27), simple positive thyroid autoantibody (ARR=1.32, 95%CI: 1.15-1.52), and hypothyroidism accompanied with positive thyroid autoantibody (ARR=1.78, 95%CI: 1.30-2.44), compared with those normal according to the twin specific pregnancy reference with negative thyroid autoantibody. CONCLUSION: The ordinary adult reference and that of singleton pregnancy may lead to under-diagnosis of hypothyroidism and over-diagnosis of hyperthyroidism in first-trimester twin pregnant women. Compared with pregnant women with normal thyroid function, those missed in the diagnosis of hypothyroidism were at a higher risk of preterm delivery, while those over-diagnosed as hyperthyroidism had a similar risk of preterm delivery, indicating a need to develop and generalize twin-pregnancy-specific reference on common indicators of thyroid function. Moreover, the thyroid autoantibody should be taken into consideration in the prenatal diagnosis and treatment to twin pregnant women with hypothyroidism.

BACKGROUND AND PURPOSE: In-hospital time delays lead to a relevant deterioration of neurologic outcomes in patients with stroke with large-vessel occlusions. At the moment, CT perfusion is relevant in the triage of late-window patients with stroke. We conducted this study to determine whether one-stop management with perfusion is feasible and leads to a reduction of in-hospital times. MATERIALS AND METHODS: In this observational study, we report the first 15 consecutive transfer patients with stroke with externally confirmed large-vessel occlusions who underwent flat panel detector CT perfusion and thrombectomy in the same room. Preinterventional imaging consisted of noncontrast flat panel detector CT and flat panel detector CT perfusion, acquired with a biplane angiography system. The flat panel detector CT perfusion was used to reconstruct a flat panel detector CT angiography to confirm the large-vessel occlusions. After confirmation of the large-vessel occlusion, the patient underwent mechanical thrombectomy. We recorded time metrics and safety parameters prospectively and compared them with those of transfer patients whom we treated before the introduction of one-stop management with perfusion. RESULTS: Fifteen transfer patients underwent flat panel detector CT perfusion and were treated with mechanical thrombectomy from June 2017 to January 2019. The median time from symptom onset to admission was 241 minutes. Median door-to-groin time was 24 minutes. Compared with 23 transfer patients imaged with multidetector CT, it was reduced significantly (24 minutes; 95% CI, 19-37 minutes, versus 53 minutes; 95% CI, 44-66 minutes; P < .001). Safety parameters were comparable between groups. CONCLUSIONS: In this small series, one-stop management with perfusion led to a significant reduction of in-hospital times compared with our previous workflow. peerReviewed

In the orthorhombic (o) RMnO3 compound, it is known that the magnetic state can change from the A-type antiferromagnetic (A-AFM) through a spiral spin order (SSO) into the E-AFM state with the decrease in the R ionic radius (rR). The magnetic phase transition from the E-AFM state to the A-AFM state is expected, but no experimental realization has been reported. In this study, this process in o-Ho1-xGdxMnO3 (x: 0–0.6) is reported. A substitution of Ho with Gd enables the transition of the multiferroic ground state from the E-AFM order (at x ≤ 0.1) to the SSO (at x > 0.4). Accompanied by the quenched disorder, a multiferroic phase separation state is demonstrated in the intermediate composition range of 0.1

Nano-powders with controllable particle size, excellent magnetic properties and thermal stability of barium hexaferrite (BaFe12O19) have been synthesized via a co-precipitation/calcination technique. The phase composition, morphology and magnetic/thermal properties of the products were systematically studied. XRD patterns reveal that a long co-precipitation reaction time (5 h) and high calcination temperature (1100 °C) are beneficial for the formation of BaFe12O19 phase and decreasing the tendency to agglomeration. SEM micrographs show that the products show a hexagonal flake-like particle shape and the size are well controlled and maintained at single-domain particle size range area (

Nitrogen (N) is an important nutrient for plant growth and yield production, and rice grown in paddy soil mainly uses ammonium (NH4+) as its N source. Previous studies have shown that N status is tightly connected to plant defense; however, the roles of NH4+ uptake and assimilation in rice sheath blight disease response have not been studied previously. Here, we analyzed the effects of different N sources on plant defense against Rhizoctonia solani. The results indicated that rice plants grown in N-free conditions had higher resistance to sheath blight than those grown under N conditions. In greater detail, rice plants cultured with glutamine as the sole N source were more susceptible to sheath blight disease compared to the groups using NH4+ and nitrate (NO3–) as sole N sources. N deficiency severely inhibited plant growth; therefore, ammonium transporter 1;2 overexpressors (AMT1;2 OXs) were generated to test their growth and defense ability under low N conditions. AMT1;2 OXs increased N use efficiency and exhibited less susceptible symptoms to R. solani and highly induced the expression of PBZ1 compared to the wild-type controls upon infection of R. solani. Furthermore, the glutamine synthetase 1;1 (GS1;1) mutant (gs1;1) was more susceptible to R. solani infection than the wild-type control, and the genetic combination of AMT1;2 OX and gs1;1 revealed that AMT1;2 OX was less susceptible to R. solani and required GS1;1 activity. In addition, cellular NH4+ content was higher in AMT1;2 OX and gs1;1 plants, indicating that NH4+ was not directly controlling plant defense. In conclusion, the present study showed that the activation of NH4+ uptake and assimilation were required for rice resistance against sheath blight disease.