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2. Observation of the decay KL→π0γγ

Author

Arthur Schaffer, M. Calvetti, A. Nappi, M. Rost, Ken Peach, Daniel Fournier, H. Rohrer, R. Carosi, N. Doble, H.N. Nelson, I. Harrus, P. Mayer, J. van der Lans, R. Fantechi, C. Cerri, D.C. Cundy, P. Calafiura, G. Zech, G. Quast, R. Heinz, L. Bertanza, H.G. Sander, R. Casali, B. Panzer, G. Kesseler, H. Blümer, Konrad Kleinknecht, M. Holder, Ph. Heusse, A. Kreutz, W. Weihs, A. Bigi, A. M. Lutz, Laurent Serin, G.M. Pierazzini, V. Gibson, B. Renk, Lydia Iconomidou-Fayard, R. Werthenbach, L. Gatignon, P. Grafström, D. Coward, R. Black, H. Burkhardt, O. Perdereau, I. Mannelli, J. Muir, D. J. Candlin, E. Augé, G.D. Barr, R. Hagelberg, and H. D. Wahl

Subjects
Nuclear physics, Physics, Nuclear and High Energy Physics, Angular distribution, Branching fraction, Theoretical models, Atomic physics
Abstract

The decay mode K L → π 0 γγ has been observed with a signal of 21 events and an expected background of 1.5±0.9 events. A branching ratio for decays with invariant γγ masses above 280 MeV of (2.1±0.6)×10 −6 is calculated. This result is compared with the values estimated from theoretical models and has implications for the CP conserving contribution to K L → π 0 e + e − decay.

Published
2016

3. Observation of the decay Ks → 2γ and measurement of the decay rates KL → 2γ and KS → 2γ

Author

R. Carosi, G. Quast, M. Hassan, A. Bigi, I. Mannelli, G. Kesseler, Ian Shipsey, J. Muir, D. J. Candlin, N. Doble, D.C. Cundy, L. Bertanza, G. Dietrich, H. D. Wahl, B. Renk, Konrad Kleinknecht, Arthur Schaffer, H. G. Sander, H. Burkhardt, M. Holder, R. Chase, E. Massa, Peter Clarke, D. Heyland, M. Corti, C. Youngman, P. Steffen, R. Hagelberg, A. M. Lutz, Ph Heusse, W. Heinen, B. Panzer, R. Black, A. Nappi, W. Weihs, G. M. Pierazzini, Ken Peach, J. Steinberger, E. Auge, L. Gatignon, W. Stephenson, Clemens Becker, C. Cerri, M. Calvetti, J. van der Lans, M. Kasemann, H. Blümer, B. Pijlgroms, M. Rost, G. Zech, Daniel Fournier, H. Taureg, R. Casali, and T. Miczaika

Subjects
Nuclear physics, Physics, Nuclear and High Energy Physics, 010308 nuclear & particles physics, 0103 physical sciences, 010306 general physics, 01 natural sciences
Abstract

The decay rates of K L → 2γ and K S → 2γ have been measured at the CERN SPS. The results are Γ (K L →2 γ )/ χ (K L →2 π 0 )=0.632±0.004±0.008 and Γ (K S →2 γ )/ Γ (K L →2 γ )=2.3 ±1.0±0.4. This is the first observation of K S →2γ decays.

Published
2016

4. Low brown adipose tissue activity in endurance-trained compared with lean sedentary men

Author

Joris Hoeks, Evie P.M. Broeders, A A J J van der Lans, W.D. van Marken Lichtenbelt, Emmani B.M. Nascimento, Maarten J. Vosselman, Felix M. Mottaghy, Hannah Pallubinsky, Patrick Schrauwen, Boudewijn Brans, Humane Biologie, MUMC+: DA BV Medische staf (6), Beeldvorming, RS: NUTRIM - R1 - Metabolic Syndrome, and RS: NUTRIM - HB/BW section B

Subjects
Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Adipose tissue, THERMOGENESIS, EXERCISE, White adipose tissue, ADULT HUMANS, IRISIN, RATS, Adipose Tissue, Brown, Thinness, Endurance training, Fluorodeoxyglucose F18, Internal medicine, Brown adipose tissue, Myokine, Medicine, Humans, MESSENGER-RNA EXPRESSION, WHITE FAT, Muscle, Skeletal, COLD, GENE-EXPRESSION, Nutrition and Dietetics, business.industry, Interleukin-6, Skeletal muscle, MUSCLE, FNDC5, Fibronectins, Cold Temperature, medicine.anatomical_structure, Endocrinology, Gene Expression Regulation, Athletes, Positron-Emission Tomography, Physical Endurance, Radiopharmaceuticals, Sedentary Behavior, business, Tomography, X-Ray Computed, Thermogenesis, Biomarkers
Abstract

BACKGROUND/OBJECTIVES: It has now been unequivocally demonstrated that humans possess functional brown adipose tissue (BAT) and that human BAT can be recruited upon chronic cold stimulation. Recruitment of BAT has been postulated as a potential strategy to counteract the current global obesity epidemic. Recently, it was shown in rodents that endurance exercise training could stimulate the recruitment of brown-like adipocytes within white adipose tissue (WAT) via exercise-induced myokines such as irisin (the cleaved circulating product of the type 1 membrane protein FNDC5) and interleukin-6 (IL-6). Our objective was to test whether endurance-trained athletes had increased cold-stimulated BAT activity and browning of subcutaneous WAT compared with lean sedentary males. SUBJECTS/METHODS: Twelve endurance-trained athletes and 12 lean sedentary males were measured during 2 h of mild cold exposure to determine cold-induced BAT activity via [(18)F]fluorodeoxyglucose-positron emission tomography-computed tomography ([(18)F]FDG-PET-CT) scanning. Skeletal muscle FNDC5 expression, as well as plasma irisin and IL-6 levels were determined. In addition, a subcutaneous abdominal WAT biopsy was taken to measure gene expression of several markers for browning of WAT. RESULTS: Cold-induced BAT activity was significantly lower in athletes, and no differences in gene expression of classical brown and beige adipocyte markers were detected in subcutaneous WAT between the groups. As expected, mRNA expression of FNDC5 in skeletal muscle was significantly higher in endurance athletes but plasma irisin and Il-6 levels were similar in both groups. CONCLUSIONS: These results indicate that chronic endurance exercise is not associated with brown and beige adipocyte recruitment; in fact endurance training appears to be linked to lower the metabolic activity of BAT in humans.

Published
2015

5. Development of a Prediction Model of Disease Activity in Support of Clinical Practice - the Acrodat Experience

Author

J van der Lans-Bussemaker, A. J. van der Lely, Jens Otto Lunde Jørgensen, Pia Burman, Michael Buchfelder, Susan M. Webb, Andreas M. Pleil, Anton Luger, Xavier Badia, Christian J. Strasburger, Thierry Brue, Ezio Ghigo, Roy Gomez, and Internal Medicine

Subjects
Disease activity, Clinical Practice, Nursing, business.industry, Health Policy, Public Health, Environmental and Occupational Health, Medicine, business
Published
2015

6. Observation of the decay KLO→ e+e−ep+e−

Author

B. Renk, H. D. Wahl, B. Panzer, V. Gibson, M. Calvetti, J. van der Lans, G. Zech, A. Bigi, D.C. Cundy, D. Coward, I. Mannelli, G.M. Pierazzini, D. J. Candlin, M. Holder, M. Rost, A. Kreutz, R. Heinz, L. Gatignon, R. Casali, H.G. Sander, H.N. Nelson, R. Carosi, G.D. Barr, O. Perdereau, Paolo Calafiura, Arthur Schaffer, Niels Doble, G. Grafström, R. Hagelberg, C. Cerri, P. Mayer, Lydia Iconomidou-Fayard, G. Quast, L. Bertanza, A. Wagner, Ken Peach, Ph. Heusse, Daniel Fournier, H. Rohrer, A. Nappi, E. Augé, Konrad Kleinknecht, H. Blümer, R. Werthenbach, I. Harrus, Laurent Serin, and R. Fantachi

Subjects
Physics, Nuclear and High Energy Physics, Branching fraction, Theoretical models, Atomic physics
Abstract

Two events with the characteristic of the decay K L O → e + e − e − have been observed with a negligible expected background from which a branching ratio of (4±3)×10 −8 is derived. This result is consistent with values estimated from theoretical models based on the double internal conventional of the decay K L O → γγ .

Published
1991

7. Measurement of the rate of the decay KL→e+e−γ and observation of a form factor in this decay

Author

H. D. Wahl, P. Calafiura, R. Heinz, Ken Peach, R. Hagelberg, H.G. Sander, I. Harrus, V. Gibson, R.L. Chase, H. Blümer, R. Fantechi, Daniel Fournier, H. Rohrer, R. Black, Arthur Schaffer, B. Panzer, A. Kreutz, Konrad Kleinknecht, L. Gatignon, C. Cerri, I. Mannelli, W. Weihs, G.D. Barr, H.N. Nelson, N. Doble, P. Grafström, M. Calvetti, M. Rost, R. Casali, A. Bigi, B. Renk, R. Werthenbach, D. Coward, J. van der Lans, G. Zech, G. Kesseler, R. Carosi, G.M. Pierazzini, Lydia Iconomidou-Fayard, D.C. Cundy, J. Muir, D. J. Candlin, P. Mayer, M. Holder, Ph. Heusse, H. Burkhardt, E. Augé, G. Quast, and A. Nappi

Subjects
Nuclear physics, Physics, Nuclear and High Energy Physics, Photon, Meson, Branching fraction, Propagator, High Energy Physics::Experiment, Large sample
Abstract

A large sample of Dalitz decays, K L → e + e − γ , has been observed. The branching ratio is Γ(K L →e + e − γ) Γ(K L → all )=(9.2±0.5±0.5)×10 −6 in good agreement with theoretical predictions. We observe an enhancement at high masses in the distribution of the invariant electron-positron pair mass, compared to the distribution expected from QED. This excess is interpreted as being due to virtual mesons contributing to the photon propagator.

Published
1990

8. The NA31 ϵ'/ϵ measurement

Author

Arthur Schaffer, W. Weihs, L. Bertanza, Konrad Kleinknecht, Ken Peach, Daniel Fournier, H. Rohrer, Lydia Iconomidou-Fayard, R. Heinz, L. Gatignon, J. Muir, G.M. Pierazzini, H.G. Sander, R. Chase, D. J. Candlin, G. Kesseler, B. Renk, S. Galeotti, H.N. Nelson, V. Gibson, C. Cerri, H. Burkhardt, E. Auge, R. Black, H. Blümer, I. Harrus, A. Kreutz, I. Mannelli, J. van der Lans, G. Zech, D.C. Cundy, G. Gargani, P. Mayer, H. D. Wahl, Ph. Heusse, Peter Clarke, R. Werthenbach, R. Fantecho, A. Bigi, G. Quast, A. Nappi, D. Coward, R. Casali, Clemens Becker, Paolo Calafiura, N. Doble, Milene Calvetti, B. Panzer, P. Grafström, G.D. Barr, R. Hagelberg, M. Rost, M. Holder, and R. Carosi

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, CP violation, Atomic and Molecular Physics, and Optics
Published
1990

9. A new measurement of direct CP violation in the neutral kaon system

Author

D.C. Cundy, G.M. Pierazzini, H. D. Wahl, B. Renk, M. Calvetti, R. Werthenbach, A. Nappi, M. Rost, I. Harrus, I. Mannelli, V. Gibson, Peter Buchholz, B. Panzer, P. Calafiura, P. Mayer, R. Carosi, Laurent Serin, G. Quast, A. Wagner, Maria Chiara Carrozza, Konrad Kleinknecht, H. Blümer, R. Hagelberg, V.M. Marzulli, L. Gatignon, M. Holder, Ph. Heusse, A. Kreutz, P. Grafström, Ken Peach, R. Fantechi, H. G. Sander, C. Cerri, O. Perdereau, Daniel Fournier, H. Rohrer, G.D. Barr, Lydia Iconomidou-Fayard, Niels Doble, L. Bertanza, E. Augé, J. van der Lans, G. Zech, R. Heinz, Arthur Schaffer, H.N. Nelson, A. Bigi, D. Coward, and R. Casali

Subjects
Systematic error, Physics, Nuclear and High Energy Physics, Particle physics, Value (computer science), NA48 experiment, Molecular, Elementary particle, Atomic, Nuclear & Particles Physics, Nuclear physics, Amplitude, Particle and Plasma Physics, Energy spectrum, CP violation, Nuclear, Neutral particle, Mathematical Physics, Astronomical and Space Sciences, Particle Physics - Experiment
Abstract

A new measurement of the ratio of the CP-violating amplitudes for $K_{L} \to 2\pi^{0}$ and $K_{L} \to \pi^{+}\pi^{-}$ is reported. The measured value for $\Re = |\eta_{00} / \eta_{ +-}|^{2}$ is $0.9878 \pm 0.0026 \pm 0.0030$, where the first error is the statistical uncertainty and the second is the estimate of the systematic uncertainty. This gives a value for the parameter describing direct CP violation: $\Re$ $\epsilon'/\epsilon = (2.0 \pm 0.7) \times 10^{−3}$ .

Published
1993

10. A large-area transition radiation detector

Author

H. Blümer, I. Harrus, R. Fantechi, Konrad Kleinknecht, Clemens Becker, Paolo Calafiura, H.N. Nelson, Lydia Iconomidou-Fayard, B. Panzer, R. Heinz, L. Bertanza, E. Augé, A. Bigi, G. Gargani, R. Hagelberg, R. Ossa, H.G. Sander, H. Burkhardt, A. Kreutz, Arthur Schaffer, Ken Peach, M. Holder, H. D. Wahl, C. Cerri, D. J. Candlin, R. Carosi, G.D. Barr, M. Rost, P. Mayer, Daniel Fournier, H. Rohrer, Ph. Heusse, V. Gibson, M. Calvetti, J. van der Lans, G.M. Pierazzini, L. Gatignon, I. Mannelli, and B. Renk

Subjects
Physics, Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, business.industry, Helium ionization detector, Detector, Hydrostatic pressure, chemistry.chemical_element, Methane, Chamber pressure, Nuclear physics, chemistry.chemical_compound, Transition radiation detector, Xenon, Optics, chemistry, Detectors and Experimental Techniques, business, Instrumentation, Helium
Abstract

The construction and the operation of a large-area transition radiation detector (TRD) for the NA31 experiment at CERN are described. The TRD incorporates several novel features for stabilizing the detector response. The density of the gas mixture (xenon+helium+methane) in the detection chambers is matched to the carbon dioxide gas in the surrounding radiators by tuning the helium concentration to avoid a hydrostatic pressure difference, which would deform the chamber walls. The chamber pressure is continuously regulated by computer control to maintain it to within 1 μbar of the radiator pressure. The gas gain of each of the four chambers is regulated to better than 0.2% by changing the high voltage under computer control, using the pulse-height spectra of 16 109 Ca sources mounted on the chambers. The results of performance studies are described. The detector has a pion efficiency of 98.7% with an electron rejection of a factor of 10.

Published
1990

11. A measurement of the phases of the CP-violating amplitudes in K0→2π decays and a test of CPT invariance

Author

L. Bertanza, W. Weihs, G. Kesseler, H.N. Nelson, C. Cerri, I. Mannelli, I. Harrus, R. Carosi, H. D. Wahl, R.L. Chase, A. M. Lutz, G.M. Pierazzini, M. Kasemann, Konrad Kleinknecht, S. Roehn, L. Gatignon, Lydia Iconomidou-Fayard, R. Black, V. Gibson, J. van der Lans, G. Zech, Arthur Schaffer, E. Augé, A. Bigi, J. Muir, D. J. Candlin, D. Coward, D.C. Cundy, R. Heinz, H.G. Sander, R. Casali, B. Renk, H. Burkhardt, A. Nappi, H. Blümer, P. Mayer, M. Holder, Ph. Heusse, Peter Clarke, G. Gargani, G. Quast, Clemens Becker, Ken Peach, Daniel Fournier, H. Rohrer, N. Doble, P. Grafström, R. Fantechi, B. Panzer, P. Calafiura, R. Hagelberg, M. Calvetti, and M. Rost

Subjects
Phase difference, Physics, Nuclear physics, Nuclear and High Energy Physics, Particle physics, Antiparticle, Amplitude, CPT symmetry, CP violation, Limit (mathematics), Mass matrix, lcsh:Physics, lcsh:QC1-999
Abstract

The phases of the CP-violating amplitudes in K0→π+π− and K0→2π0 decays, φ+−=46.9°±2.2° and φ00=47.1°±2.8°, have been measured in the same experiment, and a direct comparison gives the phase difference φ00−φ+−=0.2°±2.9°. This result leads to an upper limit on possible CPT violation in the K0 mass matrix, of |(m K 0 −m K 0 )/m K 0 | −18 at the 95% confidence level and is the most stringent test of the equality of particle and antiparticle masses.

Published
1990

12. Search for the decay KL→π0e+e−

Author

Ken Peach, G.D. Barr, Lydia Iconomidou-Fayard, H.N. Nelson, G. Kesseler, Ian Shipsey, H. Burkhardt, B. Pijlgroms, Daniel Fournier, W. Weihs, H. Rohrer, Konrad Kleinknecht, H. Blümer, H. D. Wahl, B. Panzer, W. Stephenson, Arthur Schaffer, M. Kasemann, P. Mayer, N. Doble, A. M. Lutz, A. Bigi, I. Mannelli, R. Hagelberg, L. Bertanza, M. Holder, Ph. Heusse, V. Gibson, H. G. Sander, Peter Clarke, C. Cerri, J. van der Lans, G. Zech, J. Steinberger, B. Renk, J. Muir, E. Augé, D. J. Candlin, G. M. Pierazzini, R.L. Chase, H. Taureg, T. Miczaika, R. Casali, C. Youngman, G. Quast, M. Corti, D. Coward, A. Nappi, R. Heinz, R. Carosi, D.C. Cundy, P. Calafiura, M. Calvetti, M. Rost, R. Black, L. Gatignon, and I. Harrus

Subjects
Nuclear physics, Physics, Nuclear and High Energy Physics, Large Hadron Collider, Event (relativity), Limit (mathematics)
Abstract

A search for the decay KL→π0e+e− has been performed at the CERN SPS. One candidate event has been found, compatible with an expected background of 1.5 events. The corresponding upper limit for the branching ration is Γ(KL→π0e+e−)Γ(KL → all)

Published
1988

13. A comparison of direct photon, π0 in p and pp interactions at the CERN ISR

Author

K. Kulka, E. Vella, Ulf Mjörnmark, J. Lindsay, E. Rosso, Borge Svane Nielsen, H. Bøggild, M. D. Gibson, Alevtina Shmeleva, Yona Oren, K. H. Hansen, P. Dam, Christine Kourkoumelis, R. Carosi, Vincent Hedberg, E. Dahl-Jensen, T. Ludlam, P. W. Jeffreys, V. Sidorov, W. E. Cleland, C. L. Woody, Odette Benary, H. Specht, S. Katsanevas, C.W. Fabjan, W. Frati, J. W. Hiddleston, Torsten Paul Ake Åkesson, T. Jensen, S. Almehed, J. A. Thompson, Volker D. Burkert, A. Markou, W. A. Zajc, E. G. Anassontzis, G. Damgaard, S. Dagan, Ulrich Goerlach, Y. Choi, R. Kroeger, J. van der Lans, Richard Batley, W. J. Willis, Pavlos Ioannou, Boris Dolgoshein, R. Møller, Howard Gordon, Michael Albrow, I. Stumer, P. Frandsen, I. Dahl-Jensen, G. Thorstenson, V. Kantserov, P. Vasilev, G. Kesseler, A. Nilsson, H. Brody, A. Kalinovsky, A. A. Carter, W. Witzeling, G. Piskounov, T. Killian, L. H. Olsen, A. Rudge, Göran Jarlskog, W. R. Molzon, M.W. Evans, M. Winik, B. Lörstad, Yu. Golubkov, N. A. McCubbin, P. Nevsky, B. Callen, P.C. Cecil, D. Lissauer, Sherman Frankel, J. R. Carter, I. Gavrilenko, I. Mannelli, J. E. Hooper, S. Eidelman, Horst Breuker, S. Maiburov, V. Chernyatin, M. Sullivan, Robert B. Palmer, O. Botner, J.G. Williamson, L. K. Resvanis, Jurgen Schukraft, and D.C. Rahm

Subjects
Physics, Nuclear physics, Nuclear and High Energy Physics, Particle physics, Large Hadron Collider, Photon, Significant difference, Rapidity
Abstract

We have measured the production of direct photons, π 0 's, and η's in p p and pp collisions at √ s =53 GeV in the range 2≈ p T ≈6 GeV/ c for the central rapidity region | y | 0.4. No statistically significant difference between pp and pp interactions is observed.

Published
1985

14. Charged particle production and correlations at high transverse momentum at the CERN intersecting storage rings

Author

G. von Dardel, Odette Benary, A. Melin, B. Schistad, David Ja Cockerill, P. Dam, W. M. Evans, H. Bøggild, P. Jeffreys, A. Hallgren, T. Killian, W. R. Molzon, R. Møller, M. Winik, K. H. Hansen, P. Frandsen, Borge Svane Nielsen, S. Henning, J. E. Hooper, B. Lörstad, T. Jensen, Yona Oren, N. A. McCubbin, W. J. Willis, G. Damgaard, Howard Gordon, Michael Albrow, A. Rudge, I. Dahl-Jensen, Torsten Paul Ake Åkesson, L. Rosselet, B. W. Heck, T. W. Ludlam, D. Lissauer, O. Botner, J. Lindsay, E. Lohse, C.W. Fabjan, M. D. Gibson, Anders Nilsson, S. Ø. Nielsen, E. Dahl-Jensen, H. Brody, S. Almehed, V. Burkert, W. Witzeling, H. J. Hilke, S. Dagan, C. L. Woody, W. Frati, J. W. Hiddleston, L. H. Olsen, R. H. Schindler, Göran Jarlskog, Sherman Frankel, J. van der Lans, G. Kesseler, U. Mjörnmark, and E. Rosso

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Range (particle radiation), Large Hadron Collider, Spectrometer, Intersecting Storage Rings, Charged particle, Nuclear physics, Transverse momentum, Particle, Nuclear Experiment, Charged particle beam, Particle Physics - Experiment
Abstract

We study the production of identified charged particles in pp collisions at a c.m. energy of 63 GeV in events with an identified high-pT trigger particle. The measurements were performed at the CERN Intersecting Storage Rings using the Axial Field Spectrometer. Production ratios are presented as a function of pT in the range 2.5 to 8 GeV/c.

Published
1984

15. First evidence for direct CP violation

Author

W. Weihs, H. G. Sander, Ken Peach, R.L. Chase, H. Burkhardt, W. Stephenson, G. Dietrich, B. Pijlgroms, Daniel Fournier, M. Corti, R. Carosi, D.C. Cundy, D. Coward, E. Massa, Clemens Becker, J. Muir, Ian Shipsey, D. J. Candlin, J. Steinberger, B. Panzer, Konrad Kleinknecht, G. M. Pierazzini, D. Heyland, A. M. Lutz, G. Kesseler, N. Doble, H. Blümer, A. Bigi, I. Mannelli, Lydia Iconomidou-Fayard, R. Casali, C. Cerri, W. Heinen, Arthur Schaffer, M. Holder, Ph. Heusse, Peter Clarke, M. Kasemann, C. Youngman, G. Gargani, R. Hagelberg, G. Quast, E. Augé, J. van der Lans, G. Zech, A. Nappi, H. Taureg, M. Calvetti, M. Rost, H. D. Wahl, L. Gatignon, R. Black, T. Miczaika, B. Renk, V. Gibson, Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), NA31, and Starita, Sabine

Subjects
Quark, Physics, Particle physics, Nuclear and High Energy Physics, [PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], 010308 nuclear & particles physics, Branching fraction, Nuclear Theory, 01 natural sciences, 010305 fluids & plasmas, Nuclear physics, Transition radiation detector, Amplitude, Pion, Isospin, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], CP violation, High Energy Physics::Experiment, 010306 general physics, Phenomenology (particle physics), Particle Physics - Experiment
Abstract

Since CP violation was first observed in the decay of the long-lived neutral kaon into two pions [1], it remains one of the enigmas in particle physics. Whilst CP violation is manifest in neutral kaon decays, the search for CP-violating effects has elsewhere been unsuccessful. In the phenomenology of CP violation in the neutral kaon system [2], the short- and long-lived mass eigenstates are usually defined in terms of the CP eigenstates K1 (CP = + 1) and K2 (CP = - 1) as Ks ≈ K1 + ?K2 and KL ≈ K2 + ?K1. The parameter ? describes CP violation induced by kaon state-mixing. Direct CP violation may also occur in the decay of K2 into two pions with a relative amplitude ?′, which is non-zero in the case of a phase difference between the amplitudes A0 and A2 for the decay into isospin O and 2 states of two pions. Before the present measurement, all experimental results were compatible with ? = 2.27 × 10-3 exp (i 43.70) and with the Superweak Model [3], in which state-mixing is the only source of CP violation and ?′ = 0. In the Standard Model with six weakly interacting quarks [4], direct CP violation as well as state-mixing is introduced by transitions via heavy-quark intermediate states. Based on this, a small, but non-zero, value of ?′ is predicted [5]. To a good approximation, ?′ /? is related to the double ratio R of the relative decay rates of the long- and short-lived neutral kaons into two neutral and two charged pions as Re (?′/?) = 1/6 × (1 - R).

Published
1988
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16. Bose-Einstein correlations in αα, pp and interactions

Author

L. H. Olsen, A. Markou, H. J. Hilke, David Ja Cockerill, J. van der Lans, R. Batley, R. Møller, Odette Benary, I. Dahl-Jensen, Howard Gordon, M. Sullivan, G. Kesseler, P. Cecil, S. Almehed, W. M. Evans, A. Kalinovsky, T. Killian, P. Frandsen, P. Dam, S. Dagan, W. R. Molzon, M. Winik, K. Kulka, R. H. Schindler, Göran Jarlskog, W. J. Willis, E. Vella, C.W. Fabjan, G. Damgaard, Michael Albrow, Ulrich Goerlach, B. Lörstad, Ulf Mjörnmark, Volker D. Burkert, N. A. McCubbin, H. Brody, Yona Oren, C. L. Woody, J. Lindsay, J. R. Carter, Vincent Hedberg, T. Ludlam, E. Rosso, W. Frati, J. W. Hiddleston, A. Rudge, W. A. Zajc, S. U. Chung, D. Lissauer, Anders Nilsson, P. Jeffreys, W. Cleland, Sherman Frankel, B. W. Heck, Horst Breuker, Borge Svane Nielsen, J.G. Williamson, K. H. Hansen, R. Kroeger, W. Witzeling, M. D. Gibson, Torsten Paul Ake Åkesson, L. Rosselet, A. A. Carter, S. Eidelman, E. Dahl-Jensen, O. Botner, H. Bøggild, J. E. Hooper, and G. Thorstenson

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, chemistry.chemical_element, Bose–Einstein correlations, High multiplicity, Central region, Nuclear physics, Particle type, Pion, chemistry, Rapidity, Multiplicity (chemistry), Helium
Abstract

Bose-Einstein correlations between pions produced in the central region of rapidity in αα, pp and p p interactions have been studied at the ISR. The parameters r and τ c -often interpreted as the radius and depth of the π-emitting region - are found to be independent of incident particle type but to depend on the mean charged multiplicity. In high multiplicity events, the pions appear to originate from a larger space-time region.

Published
1983

17. Properties of a fine-sampling uranium-copper scintillator hadron calorimeter

Author

A. Di Ciaccio, J. Lindsay, D. Lissauer, C.W. Fabjan, Y. Oren, J. van der Lans, W. J. Willis, G. Kesseler, W. R. Molzon, Torsten Paul Ake Åkesson, L. Rosselet, J. Renaud, Richard Wigmans, P. Dam, O. Botner, G. Di Tore, Borge Svane Nielsen, W. Witzeling, G. Delavallade, L. H. Olsen, C. Woody, Ch. J. Wang, I. Stumer, J.C. Berset, M. Burns, M. Harris, E. Vella, S. Dagan, Odette Benary, P. Jeffreys, W.E. Cleland, M. Winik, Howard Gordon, R. H. Schindler, and Richard Batley

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Range (particle radiation), Large Hadron Collider, Calorimeter (particle physics), Physics::Instrumentation and Detectors, Hadron, chemistry.chemical_element, Astrophysics::Cosmology and Extragalactic Astrophysics, Electron, Scintillator, Wavelength shifter, Uranium, Nuclear physics, chemistry, High Energy Physics::Experiment, Detectors and Experimental Techniques, Nuclear Experiment, Instrumentation
Abstract

We present results obtained with a uranium/copper scintillator fine-sampling calorimeter with wavelength shifter readout. Test beam measurements made with e±, π± and protons in the momentum range 0.3–40 GeV/c are presented. The calorimeter achieves energy resolutions of σ(E) E = 0.36 √E and 0.16 √E for hadrons and electrons, respectively. The measured ratio of response for electrons to that for hadrons is 1.11, for energies of 2 GeV or more. The spatial resolution achieved for single particles at normal incidence is ∼1 cm for electromagnetic showers and ∼3 cm for hadronic showers. Operational experience over three years of running at the CERN ISR, including operation at very high luminosities (∼1.4×1032 cm−2 s−1) is described.

Published
1985

18. A measurement of alpha-alpha elastic scattering at the CERN ISR

Author

L. H. Olsen, D. Weygand, Torsten Paul Ake Åkesson, K. Kulka, H. Bøggild, O. Botner, David Ja Cockerill, R. Møller, M. Sullivan, W. J. Willis, D. Lissauer, Vincent Hedberg, Michael Albrow, J. van der Lans, C.W. Fabjan, W. M. Evans, B. Lörstad, A. Rudge, I. Stumer, Horst Breuker, S. Almehed, E. Vella, S. Dagan, K. H. Hansen, P. Frandsen, I. Dahl-Jensen, J. R. Carter, J. A. Thompson, T. W. Ludlam, Sherman Frankel, Ulrich Goerlach, J. Lindsay, J. G. Williamson, A. A. Carter, Richard Batley, P. Dam, J. E. Hooper, W. A. Zajc, M. J. Goodrick, T. W. Pritchard, H. Brody, Borge Svane Nielsen, G. Damgaard, C. L. Woody, W. Frati, J. W. Hiddleston, R. Kroeger, P. Cecil, Yona Oren, G. Thorstenson, Odette Benary, M. D. Gibson, E. Dahl-Jensen, W. Cleland, S. U. Chung, Göran Jarlskog, Howard Gordon, W. R. Molzon, M. Winik, and N. A. McCubbin

Subjects
Nuclear reaction, Elastic scattering, Physics, Nuclear and High Energy Physics, Range (particle radiation), Particle physics, Scattering, Extrapolation, Alpha particle, Charged particle, Nuclear physics, Cross section (physics), Nuclear Experiment, Particle Physics - Experiment
Abstract

We present measurements of the αα elastic scattering differential cross section at √ s = 126 GeV in the range 0.05 ⩽ ‖ t ‖ c ) 2 . The data give an improved definition of the first cross section minimum at ‖ t ‖ = 0.098 (GeV/ c ) 2 and are consistent with theotheoretical models of nucleus-nucleus scattering. The αα total cross section obtained by extrapolation to the optical point is 280 ± 70 mb.

Published
1985

19. Search for a neutral Higgs particle in the decay sequence $K^{0}_{L} \to \pi^{0}H^{0}$ and $H^{0} \to e^{+}e^{-}$

Author

H. Taureg, H.N. Nelson, A. M. Lutz, M. Calvetti, M. Rost, G.M. Pierazzini, G.D. Barr, H. G. Sander, B. Renk, H. D. Wahl, Arthur Schaffer, Ken Peach, T. Miczaika, W. Stephenson, W. Weihs, R.L. Chase, B. Pijlgroms, I. Mannelli, R. Heinz, A. Nappi, Daniel Fournier, H. Rohrer, L. Gatignon, P. Calafiura, B. Panzer, V. Gibson, L. Bertanza, C. Youngman, H. Blümer, Ian Shipsey, N. Doble, Konrad Kleinknecht, C. Cerri, J. Muir, D. J. Candlin, Lydia Iconomidou-Fayard, P. Grafström, R. Casali, G. Quast, I. Harrus, A. Bigi, J. van der Lans, G. Zech, M. Corti, D. Coward, G. Kesseler, M. Kasemann, R. Hagelberg, R. Carosi, D.C. Cundy, R. Black, E. Augé, P. Mayer, M. Holder, Ph. Heusse, Peter Clarke, and H. Burkhardt

Subjects
Physics, Nuclear and High Energy Physics, Sequence, Particle physics, Range (particle radiation), Large Hadron Collider, Branching fraction, Elementary particle, Super Proton Synchrotron, Standard Model, Nuclear physics, Higgs boson, High Energy Physics::Experiment, Particle Physics - Experiment
Abstract

We have searched for the sequence of decays K L 0 → π 0 H 0 and H 0 →e + e − at the CERN Super Proton Synchrotron (SPS), and have allowed for a non-zero H 0 lifetime. Three candidates have been seen, consistent with an expected background of 3.3. Limits on the branching ratio product in the range 10 −8 –10 −7 are presented as a function of the mass and lifetime of the H 0 . These can be used to restrict the neutral Higgs of the minimal standard model.

Published
1989

20. FIRST EVIDENCE FOR DIRECT CP VIOLATION

Author

H. BURKHARDT, P. CLARKE, D. COWARD, D. CUNDY, N. DOBLE, L. GATIGNON, V. GIBSON, R. HAGELBERG, G. KESSELER, J. VAN DER LANS, I. MANNELLI, T. MICZAIKA, A.C. SCHAFFER, J. STEINBERGER, H. TAUREG, H. WAHL, C. YOUNGMAN, G. DIETRICH, W. HEINEN, R. BLACK, D.J. CANDLIN, J. MUIR, K.J. PEACH, B. PIJLGROMS, I.P. SHIPSEY, W. STEPHENSON, H. BLÜMER, M. KASEMANN, K. KLEINKNECHT, B. PANZER, B. RENK, E. AUGÉ, R.L. CHASE, M. CORTI, D. FOURNIER, P. HEUSSE, L. ICONOMIDOU-FAYARD, A.M. LUTZ, H.G. SANDER, A. BIGI, M. CALVETTI, R. CAROSI, R. CASALI, C. CERRI, G. GARGANI, E. MASSA, A. NAPPI, G.M. PIERAZZINI, C. BECKER, D. HEYLAND, M. HOLDER, G. QUAST, M. ROST, W. WEIHS, and G. ZECH

Subjects
Physics, Particle physics, Large Hadron Collider, CP violation
Published
1989

21. The beam and detector for a high-precision measurement of cp violation in neutral-kaon decays

Author

E. Massa, H. Taureg, E. Auge, M. Calvetti, C. Youngman, M. Rost, B. Panzer, G. Kesseler, A. M. Lutz, A. Nappi, S. Galeotti, R. Carosi, D.C. Cundy, M. Kasemann, W. Heinen, Ian Shipsey, R. Hagelberg, D. Heyland, A. Bigi, I. Mannelli, Gunter Quast, R. Black, R. Chase, J. Steinberger, H. Blümer, F. Eisele, G. M. Pierazzini, L. Gatignon, M. Holder, Ph Heusse, H. D. Wahl, J. Muir, G. Dietrich, D. J. Candlin, T. Miczaika, R. Casali, W. Stephenson, W. Weihs, M. Corti, H. G. Sander, G. Zech, P. Steffen, J. van der Lans, B. Renk, C. Cerri, R. Fantechi, H. Burkhardt, Peter Clarke, N. Doble, Ken Peach, B. Pijlgroms, Daniel Fournier, Konrad Kleinknecht, Arthur Schaffer, Clemens Becker, D. Passuello, Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), NA31, and Starita, Sabine

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Large Hadron Collider, [PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], Physics::Instrumentation and Detectors, 010308 nuclear & particles physics, Detector, Cryogenics, 01 natural sciences, 7. Clean energy, Super Proton Synchrotron, Calorimeter, Nuclear physics, Magnet, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Physics::Accelerator Physics, CP violation, High Energy Physics::Experiment, Detectors and Experimental Techniques, 010306 general physics, Instrumentation, Beam (structure)
Abstract

The K0 beam and detector used for a high-precision measurement of the CP-violation parameter ϵ′ at the CERN Super Proton Synchrotron (SPS) are described. The beam provides KL and KS alternately through a common decay region. The detection of the decays is based on wire chambers and calorimeters without employing a magnet. The trigger and readout system achieve a high selectively for the suppressed, CP-violating, two-pion decays of the KL by incorporation of hard-wired processors. The readout is based on Fastbus for maximum data rates.

Published
1988

22. HUMMINGBIRD FILM DIGITIZER SYSTEM

Author

H J Slettenhaar, J van der Lans, and J Pellegrin

Subjects
Physics, Data processing, Optics, biology, business.industry, Cathode ray tube, law, Computer graphics (images), biology.animal, Cathode ray, Hummingbird, business, law.invention
Published
1968

23. More than a decade of real-world experience of pegvisomant for acromegaly: ACROSTUDY.

Author

Fleseriu M, Führer-Sakel D, van der Lely AJ, De Marinis L, Brue T, van der Lans-Bussemaker J, Hey-Hadavi J, Camacho-Hubner C, Wajnrajch MP, Valluri SR, Palladino AA, Gomez R, and Salvatori R

Subjects
Acromegaly epidemiology, Adenoma drug therapy, Adenoma epidemiology, Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Cohort Studies, Europe epidemiology, Female, Follow-Up Studies, Growth Hormone-Secreting Pituitary Adenoma drug therapy, Growth Hormone-Secreting Pituitary Adenoma epidemiology, History, 21st Century, Human Growth Hormone therapeutic use, Humans, Infant, Male, Middle Aged, Retrospective Studies, Treatment Outcome, United States epidemiology, Young Adult, Acromegaly drug therapy, Human Growth Hormone analogs & derivatives
Abstract

Objective: To report the final long-term safety and efficacy analyses of patients with acromegaly treated with pegvisomant from the ACROSTUDY., Design: Global (15 countries), multicentre, non-interventional study (2004-2017)., Methods: The complete ACROSTUDY cohort comprised patients with acromegaly, who were being treated with pegvisomant (PEGV) prior to the study or at enrolment. The main endpoints were long-term safety (comorbidities, adverse events (AEs), pituitary tumour volumes, liver tests) and efficacy (IGF1 changes)., Results: Patients (n = 2221) were treated with PEGV for a median of 9.3 years (range, 0-20.8 years) and followed up for a median of 7.4 years (range, 0-13.9 years). Before PEGV, 96.3% had received other acromegaly treatments (surgery/radiotherapy/medications). Before PEGV treatment, 87.2% of patients reported comorbidities. During ACROSTUDY, 5567 AEs were reported in 56.5% of patients and of these 613 were considered treatment-related (in 16.5% of patients) and led to drug withdrawal in 1.3%. Pituitary imaging showed a tumour size increase in 7.1% of patients; the majority (71.1%) reported no changes. Abnormal AST or ALT liver tests occurred in 3.2% of patients. IGF1 normalization rate improved over time, increasing from 11.4% at PEGV start to 53.7% at year 1, and reaching 75.4% at year 10 with the use of ≥30 mg PEGV/day in an increasing proportion of patients., Conclusion: This comprehensive review of the complete cohort in ACROSTUDY confirmed the overall favourable benefit-to-risk profile and high efficacy of PEGV as mono- and combination therapy in patients with an aggressive course/uncontrolled/active acromegaly requiring long-term medical therapy for control.

Published
2021
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24. Development of ACRODAT ® , a new software medical device to assess disease activity in patients with acromegaly.

Author

van der Lely AJ, Gomez R, Pleil A, Badia X, Brue T, Buchfelder M, Burman P, Clemmons D, Ghigo E, Jørgensen JOL, Luger A, van der Lans-Bussemaker J, Webb SM, and Strasburger CJ

Subjects
Humans, Acromegaly diagnosis, Software
Abstract

Purpose: Despite availability of multimodal treatment options for acromegaly, achievement of long-term disease control is suboptimal in a significant number of patients. Furthermore, disease control as defined by biochemical normalization may not always show concordance with disease-related symptoms or patient's perceived quality of life. We developed and validated a tool to measure disease activity in acromegaly to support decision-making in clinical practice., Methods: An international expert panel (n = 10) convened to define the most critical indicators of disease activity. Patient scenarios were constructed based on these chosen parameters. Subsequently, a panel of 21 renowned endocrinologists at pituitary centers (Europe and Canada) categorized each scenario as stable, mild, or significant disease activity in an online validation study., Results: From expert opinion, five parameters emerged as the best overall indicators to evaluate disease activity: insulin-like growth factor I (IGF-I) level, tumor status, presence of comorbidities (cardiovascular disease, diabetes, sleep apnea), symptoms, and health-related quality of life. In the validation study, IGF-I and tumor status became the predominant parameters selected for classification of patients with moderate or severe disease activity. If IGF-I level was ≤1.2x upper limit of normal and tumor size not significantly increased, the remaining three parameters contributed to the decision in a compensatory manner., Conclusion: The validation study underlined IGF-I and tumor status for routine clinical decision-making, whereas patient-oriented outcome measures received less medical attention. An Acromegaly Disease Activity Tool (ACRODAT) is in development that might assist clinicians towards a more holistic approach to patient management in acromegaly.

Published
2017
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