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The aim of this study was to perform a pilot histological and quantitative analysis of the blood vessels accompanying the epicardial nerves (vasa nervorum) in the porcine hearts. Twenty healthy porcine hearts were used in this study. The blood vessels were analyzed by light microscopy using four different staining techniques in transverse sections taken from the upper, middle, and lower segments of the anterior part of the interventricular region and the adjacent parts of the right and left ventricles containing epicardial nerves and the endocardial peripheral parts of the Purkinje fibers. In total, 317 epicardial nerves were detected. The vasa nervorum were present in 75.7% of these nerves. The vasa nervorum resembled arterioles and postcapillary and collecting venules. One hundred and forty nine epicardial nerves were perivascular, located in the adventitia of the anterior interventricular artery and vein. The remaining 168 nerves ran freely through the epicardial interstitium. The presence of the vasa nervorum was not related to topographical location or nerve diameter. Additionally, from a total of 33 analyzed ventricular complexes of Purkinje fibers small blood vessels located in their proximity were identified in only two cases. It can be concluded that the majority of the anterior epicardial nerves of porcine heart possess well-developed vasa nervorum. In contrast, similar blood vessels are rarely present in the vicinity of the Purkinje fibers. The data obtained contribute to a better understanding of the nutrition of the cardiac nerves.

The aim of the study was to investigate the existence of valves in small peripheral coronary veins of porcine hearts. The study was performed on 20 porcine hearts using standard histological methods. The veins in the subepicardial and intramyocardial regions of the anterior and posterior parts of the interventricular septum and in the wall of the right atrium were studied. Valves were present in intramyocardial veins (diameter of 75-180 μm), in the veins located just beneath the external surface of the myocardium (diameter 120-170 μm) and in the terminal segments of the ventricular veins (diameter 250 μm) opening into the stems of the anterior interventricular vein and middle cardiac vein. Valves were also recorded in most veins of the subepicardial space. The described rich presence of valves in the small coronary veins may contribute to a better comprehension of their hemodynamic properties. These findings may also help to improve the understanding of the efficacy of retrograde application of medications, a novel technique in cardiology and cardiac surgery.

INTRODUCTION The purpose of this study was to highlight the historical importance of the events of the year 1848 for Czech surgery and to provide a brief report on medical dissertations written in Prague between the years 1832 and 1846, focused on the surgical treatment of incarcerated hernias. METHODS The study was designed as a literary search using original materials of the Archive of Charles University, the National Library of the Czech Republic, and international sources. RESULTS In the year 1848 surgery became an official part of the university medical curriculum after a long process of integration. We identified and analysed ten medical dissertations on anatomy, diagnosis and treatment of incarcerated hernias, completed in the above mentioned period. CONCLUSION Our results illustrate both the successful completion of implementation of surgery into the medical curriculum, as well as the ways and the quality of both conservative and surgical treatments of incarcerated hernias between 1832 and 1846.

Reduced lung function is associated with overall and cardiovascular mortality. Chronic low grade systemic inflammation is linked to impaired lung function and cardiovascular outcomes. We assessed the association of lung function with overall 8-year mortality in 867 individuals of the Activity and Function in the Elderly study using confounder-adjusted Cox proportional hazards models (including gait speed and daily walking time as measures of physical function) without and with adjustment for inflammatory and cardiac markers. Forced expiratory volume in 1 s/forced vital capacity ( FEV1/FVC) but not FVC was related to mortality after adjustment for physical function and other confounders. Additional adjustment for inflammatory and cardiac markers did not change the hazard ratios (HR) markedly, e.g. for a FEV1/ FVC below 0.7 from 1.55 [95% confidence-interval (CI) 1.14���2.11] to 1.49 (95% CI 1.09���2.03). These independent associations were also observed in the apparently lung healthy subpopulation with even higher HRs up to 2.76 (95% CI 1.52���4.93). A measure of airflow limitation but not vital capacity was associated with overall mortality in this community-dwelling older population and in the subgroup classified as lung healthy. These associations were independent of adjustment for inflammatory and cardiac markers and support the role of airflow limitation as independent predictor of mortality in older adults., publishedVersion

Introduction The vasa vasorum interna were described during the last decade as a special kind of vessels originating directly from the lumen of the paternal artery and participating in the nourishment of its wall, especially of the aorta and coronary arteries. At the same time, their existence was repeatedly denied/negated by many other authors. Aim The purpose of the actual study was the anatomical verification of the existence of the vasa vasorum interna in porcine coronary arteries. Materials and methods The vascular supply was studied on the wall of the anterior interventricular branch of the left coronary artery on 36 hearts taken from healthy pigs. Light microscopy, vascular injections and scanning electron microscopy were used for the analysis of 141 samples. Results In only two cases small arteries resembling vasa vasorum interna and originating directly from the lumen of the coronary artery were found. But, in both cases these vessels ran without branching, passed over the whole thickness of adventitia and branched in the wider periarterial space. In contrast to this all feeding arteries of the vasa vasorum arose from the larger branches of the paternal artery, branched entirely in its adventitia and did not enter the media. Conclusion Due to the very low incidence of these small arteries originating from the lumen of the paternal artery and the absence of their participation on the nourishment of the arterial wall we came to the conclusion that it is not suitable to use the term “vasa vasorum interna” for their designation.

The aim of the study was to describe the origin of the Latin anatomical term vasa vasorum and its role in current medical research and to present examples of grammatical errors in its use. Literary searches oriented on the term vasa vasorum were used to identify publications using it in the medical literature from the seventeenth century up to the present. The Latin term vasa vasorum was introduced by Ludwig in 1739. The vasa vasorum became an important topic in clinical research around the middle of the twentieth century, with implications in angiology, cardiology and cardiosurgery. We report 18 grammatical errors concerning the use of the term vasa vasorum, starting from the year 1959. A similar decline in the correct use of Latin terminology is also evident in other medical research disciplines. The numerous errors found in the use of Latin terminology in recent medical literature have occurred as a consequence of decreased use of Latin in the medical community. The only way to improve this situation is by improving awareness of international standard anatomical terminology, which is available worldwide in both Latin and English.

This study was designed to investigate the distribution of vasa vasorum in walls of failed aorto-coronary venous grafts. Fifty-one diseased venous grafts harvested from 39 patients underwent qualitative histological evaluation. The morphology of the grade of the pathological changes and the extent of the vascularisation were examined, and related to the length of the interval between the primary surgery and the explantation. The obtained results were placed into five groups, substantially differing one from the other in morphology and vascularisation. The intervals between grafts implantation and explantation ranged from 1 day to 35 years. The onset of arterialization of the graft media was observed on average at 1 month after bypass implantation. During this same time period massive intimal hyperplasia and atherosclerosis occurred. Vasa vasorum proliferation from the adventitia to the outer layers of the media was first apparent between 7 and 24 months after implantation. Proliferation of the vasa vasorum throughout the entire atherosclerotic media and hyperplastic intima continued for a much longer time interval. No correlation between neoangiogenesis and age, sex or type of bypassed coronary branch was proven. Regarding the given findings, the authors believe that changes in hemodynamic conditions and endothelial trauma are primarily responsible for the development of graft disease and that vasa vasorum proliferation is only a secondary reaction to the structural changes of the graft wall. To what extent the frequently present pre-existing intimal hyperplasia of venous bypass grafts play in the development of graft disease remains questionable.

On a pathophysiological level, angioedema can be differentiated into histamine- and bradykinin-mediated types. The prototype drug-associated, bradykinin-mediated form of angioedema is angiotensin-converting enzyme (ACE) inhibitor-induced angioedema. The hypothesized cause is a decrease in bradykinin degradation via ACE inhibition. In this scenario, other bradykinin-degrading enzymes assume major importance. When the effect of these enzymes is also diminished, e. g., due to genetic variants or external factors, compensation for the inhibition of ACE may be insufficient. An increased risk of angioedema has also been reported for other drugs, particularly when prescribed in combination with ACE inhibitors. Here, the suspected cause also relates to the degradation of bradykinin. When angioedema arises within the context of concomitant ACE inhibitor use, additive bradykinin degradation effects may be implicated.

Der Hautarzt : Organ der Deutschen Dermatologischen Gesellschaft 69(4), 298-305 (2018). doi:10.1007/s00105-017-4119-9 special issue: "Kutane Nebenwirkungen zielgerichteter Therapien", Published by Springer, Berlin

The aim of this literary search was to chart the etymology of 32 selected human skeletal muscles, representative of all body regions. In researching this study, analysis of 15 influential Latin and German anatomical textbooks, dating from the sixteenth to the nineteenth century, was undertaken, as well as reference to four versions of the official Latin anatomical terminologies. Particular emphasis has been placed on the historical development of muscular nomenclature, and the subsequent division of these data into groups, defined by similarities in the evolution of their names into the modern form. The first group represents examples of muscles whose names have not changed since their introduction by Vesalius (1543). The second group comprises muscles which earned their definitive names during the seventeenth and eighteenth century. The third group is defined by acceptance into common anatomical vernacular by the late nineteenth century, including those outlined in the first official Latin terminology (B.N.A.) of 1895. The final group is reserved for six extra-ocular muscles with a particularly poetic history, favoured and popularised by the anatomical giants of late Renaissance and 1,700 s. As this study will demonstrate, it is evident that up until introduction of the B.N.A. there was an extremely liberal approach to naming muscles, deserving great respect in the retrospective terminological studies if complete and relevant results are to be achieved. Without this knowledge of the vernacular of the ages past, modern researchers can find themselves ‘reinventing the wheel’ in looking for their answers.

The aim of the study was to gain a thorough knowledge of the topography and distribution of until now officially unnamed minute direct branches from abdominal aorta, stemming from its ventral and lateral aspects, supplying surrounding tissue, and to comprise it to the existing studies. The study was performed in fixed cadaverous material collected from India ink injections of abdominal aorta samples with large surrounding retroperitoneal tissue. The 25 samples were dissected under magnifying binocular glass, followed by graphic reconstruction; statistical analysis, and the study was preceded with detailed review of branches from abdominal aorta. For systematization of the segmental anatomy of the abdominal aorta and infrarenal segment of inferior vena cava, we defined three levels in this area. The retroperitoneal branches were most frequently situated simultaneously within all three predefined levels according to renal and inferior mesenteric arteries origin. There were 18% of retroperitoneal branches within Level 1, 39% within Level 2 and 43% within Level 3. They were branches not only from the abdominal aorta, but also from the testicular/ovarian artery, common iliac artery and in one case from the right accessory renal artery. Paired arrangement was recorded mainly cranially to the origin of inferior mesenteric artery, unpaired branches were more frequently found caudally. In conclusion, due to the terminological disunity of these arteries in the clinical literature and total absence in the anatomical literature, we propose to denominate them as anterior retroperitoneal branches of abdominal aorta (rami retroperitoneales anteriores aortae abdominalis). Clin. Anat. 27:894–899, 2014. © 2014 Wiley Periodicals, Inc.

Introduction Proton pump inhibitors (PPI) are one of the most widely used drug classes in the world. Several studies have found that users of PPIs had an increased risk of cognitive decline and dementia. This could however not be confirmed by others. Protopathic bias, in which early signs and symptoms of the disease influence drug exposure, could be a reason for these conflicting results. Given that alterations in brain volume can be seen years before the occurrence of cognitive symptoms, examining the association between PPI use and brain volume in non-demented persons would eliminate the potential of protopathic bias. Therefore, we aimed to assess the associations between PPI use and cognition and brain volume. Methods We performed a cross-sectional study based on the first 1306 participants in the Rhineland Study. The Rhineland Study is a population-based cohort study in Bonn Germany that includes people aged ≥ 30 years. Information on medication use is collected in an interview in which regularly and as needed used medication is registered. PPI use was classified as regular use of PPIs (ATC code A02BC). Participants who reported using PPIs as needed were excluded. We assessed the following cognitive domains: processing speed [Trail Making Test (TMT) A], executive functioning (TMT B - A), working memory (Digit Span Forward), and long-term memory [Verbal Learning and Memory Test (VLMT); delayed loss]. Measures for TMT and VLMT were inverted so that higher values represent better test performance for all tests. All eligible participants were scanned on Siemens 3 Tesla Prisma MRI scanners. We assessed the effect of PPI use on total brain volume, cortical grey matter volume, and ventricle volume. Processing speed and ventricle volume were log transformed. All outcome measures were z-standardized. We examined the association between PPI use and cognition using multivariable linear regression models. Within the first model we only controlled for age (m1: age). Because PPI use strongly increased with increasing age, we included variables that were a determinant for PPI use after controlling for age in the fully adjusted model (m2: age, body mass index, diabetes, hypertension, antithrombotic use, statin use and NSAID use). We subsequently examined the association between PPI use and brain volume outcomes in the same way but with additional control for head size in all models. Results We included 1130 participants [mean age 55, standard deviation (SD) 13.5; 57% women; 81 PPI users] to determine the effect of PPI use on cognition. We excluded 176 participants, 25 for missing drug information, 89 for as needed PPI use and 62 for missing cognition data. We observed no effect on processing speed with a mean SD difference [95% confidence interval (95% CI)] for m1 of 0.00 (−0.19; 0.19) and for m2 of 0.02 (−0.18; 0.22). We observed a trend towards a negative effect of PPI use with a mean SD difference (95% CI) for executive functioning, working memory and long-term memory for m1 of −0.18 (−0.40; 0.03), −0.17 (−0.40; 0.05), and −0.29 (−0.51; −0.07) and for m2 of −0.13 (−0.35; 0.10), −0.12 (−0.36; 0.11), and −0.17 (−0.39; 0.06). Effect sizes were comparable to a 5-year increase in age for executive functioning and a 9-year increase in age for working memory and long-term memory. We had MRI data in a subset of 640 participants (mean age 54, SD 13.2; 56% women; 28 PPI users). Brain volume measures were smaller in PPI users compared to non-users, but these effects were far from significant, mean SD difference (95% CI) for total brain volume, cortical grey matter volume, and ventricle volume for m1 was −0.07 (−0.23; 0.09), −0.07 (−0.26; 0.12), and 0.02 (−0.27; 0.31), and for m2 was −0.05 (−0.21; 0.12), −0.03 (−0.23; 0.16) and −0.06 (−0.36; 0.24). Conclusions Given our small sample size and relatively young population, these results suggest a possible effect of PPI use on brain structure and function and warrant further investigation in larger samples.

Jan Jesensky (Johannes Jessenius) ranks among the outstanding Renaissance polymaths of Central Europe. Stemming from Horne Jaseno (present-day Slovakia), born in Wrócław (Poland), he studied philosophy and medicine in Wittenberg, Leipzig (Germany) and Padua (Italy), worked in Wrócław, Wittenberg, Prague (Czech Republic) and Vienna (Austria), and was executed in Prague. He was influenced by and himself impacted upon a large area of the pre-30-year-war Europe science, learning and politics. The year 2011 marked the 410th anniversary of the publication of his famous description of the public dissection performed in Prague, as well as the 390th anniversary of his death. His scientific and editorial work covers not only anatomy but also surgery, internal medicine, infectious diseases and even philosophy and poetry. Moreover, he was very active as University Rector (in both Wittenberg and Prague) and also as politician of the Protestant fraction in Bohemia, which unfortunately led to his violent death. He was an excellent promoter of his own person and work and he understood and exerted dexterously the power of publicity.

This article focuses on Johannes Jessenius (Ján Jesenský) (1566-1621), with particular attention paid to his famous Prague dissection and its publication (2011 marking its 410(th) anniversary). Jessenius was a physician, surgeon, anatomist, scholar, philosopher, and university authority. We focus on the life and main contribution of Jessenius based on his 1600 Prague dissection, the Anatomiae, Pragae (1601). Borovanský described Jessenius' book as "not as a textbook, but as a publication aiming at educated laymen with the purpose of advertising, filled with quotations of old classical authors." This work presents an important part of the Central European scientific, cultural, and political life of the late Renaissance period.

The aim of the study was to describe and depict the spatial arrangement of the colon microcirculatory bed as a whole. Various parts of the large intestine and terminal ileum were harvested from either cadaver or section material or gained peroperatively. Samples were then injected with India ink or methylmetacrylate Mercox resin for microdissection and corrosion casting for scanning electron microscopy. The results showed that extramural vasa recta ramified to form the subserous plexus, some of them passing underneath the colon taeniae. Branches of both short and long vasa recta merged in the colon wall, pierced the muscular layer and spread out as the submucous plexus, which extended throughout the whole intestine without any interruption. The muscular layer received blood via both the centrifugal branches of the submucous plexus and the minor branches sent off by the subserous plexus. The mucosa was supplied by the mucous plexus, which sent capillaries into the walls of intestinal glands. The hexagonal arrangement of the intestinal glands reflected their vascular bed. All three presumptive critical points are only gross anatomical points of no physiological relevance in healthy individuals. Neither microscopic weak points nor regional differences were proven within the wall of the whole large intestine. The corrosion casts showed a huge density of capillaries under the mucosa of the large intestine. A regular hexagonal pattern of the vascular bed on the inner surface was revealed. No microvascular critical point proofs were confirmed and a correlation model to various pathological states was created.

There is a close correlation between the angioarchitecture of the human testis and its inner subdivision into testicular lobules. Serial sections from paraffin and epon-embedded testicular tissue were used to examine the angioarchitecture of the human testis, and computer-aided 3-D-reconstruction was used to demonstrate the correlation between blood vessels and tissue organization. The recurrent arteries arise from the centripetal arteries, and run in the central axis of the testicular lobule. At regular intervals of on average, 300 microns the segmental arteries arise from the recurrent artery, which supplies segments of the testicular parenchyma perpendicular to the long axis of the testicular lobules. Within such a segment, the segmental artery supplies the microvasculature, which is partly surrounded by Leydig cells and partly stands in close contact with the wall of the seminiferous tubules. The venous drainage occurs through the intralobular veins, which run to the periphery of the lobule (towards the septum). These veins lead into the septum and there they join the collecting veins. A lobule can have several segments depending on its size. The base of such a tissue segment is directed towards the septum whereas the top is directed towards the centre of the lobule. Sections of several seminiferous tubules can be found in such a segment. The flow of blood from the arterial to the venous side of the testicular circulation occurs radially from the centre of the lobule to the septum.

The vascular supply of the wall of human vena saphena magna was qualitatively studied by the use of several morphological methods on both normal and pathologically changed veins. The material was obtained from patients undergoing aortocoronary bypass or surgery of the varices, and material from cadavers. Under physiological conditions, the wall of vena saphena magna is supplied by delicate system of vasa vasorum, organized in a form of feeding vessels branched into an irregular loose adventitial mesh and continuing further as a microcirculatory network supplying the two outer thirds of the media. Small local dilatations and tortuosities of adventitial veins were found on heavy varicose veins. Slight increase of vasa vasorum growing into the innermost layer of media was detected, but the hyperplastic intima remained avascular. In patients with recurrent varices or with vein thrombophlebitis intimal hyperplasia, degradation of media and thrombosis, were found. Apparent massive increase of vasa vasorum growing into the whole media, hyperplastic intima and into the organizing thrombi, were regularly observed. The increase of vasa vasorum is a part of the complex of pathophysiological reactions of the vein wall on the hypoxia developing during the most serious pathological changes, and not as the primary varicogenic factor. The vascular supply of the wall of the human vena saphena magna was qualitatively studied by the use of several morphological methods on both normal and pathologically changed veins. The material was obtained from patients undergoing aortocoronary bypass grafting or surgery of varices, as well as materials from cadavers. Under physiological conditions the wall of vena saphena magna is supplied by a delicate system of vasa vasorum. It is organized in a form of feeding vessels branched into an irregular loose adventitial mesh, which continues further as a microcirculatory network supplying the outer two thirds of the media. Small local dilatations and tortuosities of adventitial veins were found on severe varicose veins. A slight increase of the vasa vasorum growing into the innermost layer of media was detected, but the hyperplastic intima remained avascular. In patients with recurrent varices or vein thrombophlebitis, intimal hyperplasia, degradation of media and thrombosis, were found. It was regularly observed that there was an apparent, massive increase of the vasa vasorum growing into the entire media, hyperplastic intima, and into the organizing thrombi. The increase of the vasa vasorum is due to the pathophysiological reaction of the vein wall as a result of hypoxia, which develops during the most serious pathological changes. The increase is not the primary varicogenic factor.

Background: The question whether the primary increase of vasa vasorum (VV) of venous wall (i) plays an initial role in varicogenesis or (ii) is an expression of impairment of the nutritional conditions in superficial veins of lower extremities is not unambiguously solved yet. The aim of the study was to describe the arrangement of the VV within the wall of the human great saphenous vein (GSV) qualitatively, and of its tributaries at different stages of varicosis and in other pathological states like thrombophlebitis or phlebosclerosis. Material and methods: 22 patients deserving an aorto-coronary bypass surgery or GSV surgery were subdivided into three groups according to the staging of their varices and other pathology. The harvested GSV were prepared for light and scanning electron microscopy. One cadaverous specimen of GSV was injected with India ink. Results: In specimens from reticular and primary large varices local intimal hyperplasia was regularly found, partially accompanied with a mild increase of VV. Tortuosities and irregular dilations of adventitial veins were also found. In patients with recurrent primary varices or thrombophlebitis severe intimal and medial hyperplasia, thrombosis and a striking increase of VV were found. The intima remained avascular in all cases. Conclusions: Remarkable increase of VV accompanies the most severe forms of varices as well as all cases of the extreme grades of phlebosclerosis, medial hyperplasia and thrombosis. We hypothesize that this increase in VV is rather a secondary vascular reaction to the impaired metabolic conditions within the venous wall than a primary varicogenic factor.

The aim of the study was to analyze the structure and course of osteons in the compact bone of individual regions of the upper end of the femur and to consider the possible association with the course of typical peritrochanteric fracture lines. The issue of the architecture of this region has been dealt with by a number of authors since the first half of the nineteenth century, but until the present structural analysis it has been examined only by a few authors. We analyzed the structure of bones on specimens prepared by the method of repeated grinding, impregnating and polishing of the bone surface. We grounded and subsequently evaluated the bone in 20 dry specimens of the proximal femur, where the courses of the central vascular canals were described in the region of the femoral neck, the lesser trochanter, the greater trochanter, the intertrochanteric crest and line. The osteons were incorporated into a biomechanical model of the proximal femur and compared with the FEM model and correlation with the distribution of surface stresses was described. Certain areas were identified in the region of the trochanters where the course of osteons coincided with the course of the typical fracture lines of peritrochanteric fractures with typical fragments.

The aim of the study was to gain a thorough knowledge of the topography and distribution of until now officially unnamed minute direct branches from abdominal aorta, stemming from its ventral and lateral aspects, supplying surrounding tissue, and to comprise it to the existing studies. The study was performed in fixed cadaverous material collected from India ink injections of abdominal aorta samples with large surrounding retroperitoneal tissue. The 25 samples were dissected under magnifying binocular glass, followed by graphic reconstruction; statistical analysis, and the study was preceded with detailed review of branches from abdominal aorta. For systematization of the segmental anatomy of the abdominal aorta and infrarenal segment of inferior vena cava, we defined three levels in this area. The retroperitoneal branches were most frequently situated simultaneously within all three predefined levels according to renal and inferior mesenteric arteries origin. There were 18% of retroperitoneal branches within Level 1, 39% within Level 2 and 43% within Level 3. They were branches not only from the abdominal aorta, but also from the testicular/ovarian artery, common iliac artery and in one case from the right accessory renal artery. Paired arrangement was recorded mainly cranially to the origin of inferior mesenteric artery, unpaired branches were more frequently found caudally. In conclusion, due to the terminological disunity of these arteries in the clinical literature and total absence in the anatomical literature, we propose to denominate them as anterior retroperitoneal branches of abdominal aorta (rami retroperitoneales anteriores aortae abdominalis).

The transient electronic and molecular structure arising from photoinduced charge transfer in transition metal complexes is studied by X-ray powder diffraction with a 100 fs temporal and atomic spatial resolution. Crystals containing a dense array of Fe(II)-tris(bipyridine) ([Fe(bpy)(3)](2+)) complexes and their PF6- counterions display pronounced changes of electron density that occur within the first 100 fs after two-photon excitation of a small fraction of the [Fe(bpy)(3)](2+) complexes. Transient electron density maps derived from the diffraction data reveal a transfer of electronic charge from the Fe atoms and-so far unknown-from the PF6- counterions to the bipyridine units. Such charge transfer (CT) is connected with changes of the inter-ionic and the Fe-bipyridine distances. An analysis of the electron density maps demonstrates the many-body character of charge transfer which affects approximately 30 complexes around a directly photoexcited one. The many-body behavior is governed by the long-range Coulomb forces in the ionic crystals and described by the concept of electronic polarons. (C) 2013 AIP Publishing LLC. [http://dx.doi.org/10.1063/1.4800223]

We demonstrate the rotating-crystal method in femtosecond x-ray diffraction. Structural dynamics of a photoexcited bismuth crystal is mapped in a pump-probe scheme by measuring intensity changes of many Bragg reflections simultaneously.

Transient polarizations connected with a spatial redistribution of electronic charge in a mixed quantum state are induced by optical fields of high amplitude. We determine for the first time the related transient electron density maps, applying femtosecond x-ray powder diffraction as a structure probe. The prototype ionic material LiBH4 driven nonresonantly by an intense sub-40 fs optical pulse displays a large-amplitude fully reversible electron transfer from the BH4(-) anion to the Li+ cation during excitation. Our results establish this mechanism as the source of the strong optical polarization which agrees quantitatively with theoretical estimates.

Transient polarizations connected with a spatial redistribution of electronic charge in a mixed quantum state are induced by optical fields of high amplitude. We determine for the first time the related transient electron density maps, applying femtosecond x-ray powder diffraction as a structure probe. The prototype ionic material LiBH4 driven nonresonantly by an intense sub-40 fs optical pulse displays a large-amplitude fully reversible electron transfer from the BH4(-) anion to the Li+ cation during excitation. Our results establish this mechanism as the source of the strong optical polarization which agrees quantitatively with theoretical estimates.

The interplay of vibrational motion and electronic charge relocation in an ionic hydrogen-bonded crystal is mapped by X-ray powder diffraction with a 100 fs time resolution. Photoexcitation of the prototype material KH 2 PO 4 induces coherent low-frequency motions of the PO 4 tetrahedra in the electronically excited state of the crystal while the average atomic positions remain unchanged. Time-dependent maps of electron density derived from the diffraction data demonstrate an oscillatory relocation of electronic charge with a spatial amplitude two orders of magnitude larger than the underlying vibrational lattice motions. Coherent longitudinal optical and tranverse optical phonon motions that dephase on a time scale of several picoseconds, drive the charge relocation, similar to a soft (transverse optical) mode driven phase transition between the ferro- and paraelectric phase of KH 2 PO 4 .

We report the first femtosecond x-ray diffraction experiments on LiBH4. During off-resonant excitation with 800-nm pulses we observe a purely electronic modification of the transient diffraction pattern, followed by coherent atomic motions.

The first femtosecond x-ray diffraction experiments on LiBH 4 are reported. Off-resonant excitation with 800-nm pulses induces a purely electronic modification of the transient diffraction pattern, followed by coherent atomic motions.

We demonstrate the rotating-crystal method in femtosecond x-ray diffraction. A pump-probe scheme maps structural dynamics of a photoexcited bismuth crystal via changes of the diffracted intensity on a multitude of Bragg reflections.

Evaluations of measurements of the tropospheric surface condensation nuclei at the German Antarctic station for the last 8 years are presented. They show clearly the annual variation of the concentration with a maximum in austral summer, as previously seen by other investigators. In addition, a pronounced increase of the concentration of 9.63% per year has been found. The size distributions of the condensation nuclei of measurements over 2 years are evaluated and discussed. On average, they are of mono-modal shape, but individually most of them show a bimodal shape.DOI: 10.1034/j.1600-0889.1992.00009.x

Ultrafast photoinduced changes of crystal structure and charge distributions in potassium dihydrogen phosphate (KDP), KH 2 PO 4 , are mapped by femtosecond x-ray powder diffraction. The formation of HPO− 4 and H 3 PO− defects is revealed.

This article presents a detailed chronology regarding the development of terminology relating to the calcaneal tendon, from ancient times to modern day nomenclature. The notable contributions of Flemish anatomist Philip Verheyen, French surgeon Jean-Louis Petit, German anatomist and surgeon Lorenz Heister, along with the actual origin of the famous anatomical eponym “Achilles tendon” are analysed. During the study of the aforementioned authors, it was revealed that the term was first adopted, in its original French form, by J.-L. Petit in 1705 and later in 1717, in its Latin form, by L. Heister.

Professor Josef Hohlbaum (*Sept. 6, 1884 in Oberlindewiese, Northern Moravia) studied medicine in Graz, Austria. His main place of work was Leipzig, Germany, where he became an outstanding surgeon and a very good university teacher. Between 1941 and 1945, he was the last chairman of Surgery of the German University in Prague. On May 9, 1945, he was arrested by the Czech police and imprisoned in the internment camp in Klecany. At the end of June 1945, during farming work, his left leg was seriously injuried by an explosive, found by a Czech guard and thrown under Hohlbaums' foot. J. Hohlbaum received first wound treatment and was admitted to the Surgical Department of the Královské Vinohrady Hospital in Prague 10, where he spent 6 weeks. Thereafter, at his request, he was transferred to the German Military Hospital in Prague 5. During the autumn of 1945, he was transferred to Germany, his condition grew more and more worse, and, consequently, his left lower extremity had to be amputated in femore. On December 30, 1945, he died of sepsis in the Surgical department of the Hospital in Markkleeberg, near Leipzig. The authors could not find any evidence that Hohlbaums' professional contemporary, the Czech surgeon professor A. Jirásek, presented a non-ethical attitude to the injured J. Hohlbaum, and that Jirásek refused to treat him, as it has been repeatedly presented in German publications. On the contrary, it is evident from the documents found, that the care he got in Prague--with respect to the difficult circumstances--was lege artis. Hohlbaunt's life thus ended as a consequence of the situation at the end of WWII.

Citation of the original article: S. R. Oakes, M. J. Naylor, M. L. Asselin-Labat, K. D. Blazek, M. Gardiner-Garden, H. N. Hilton, M. Kazlauskas, M. A. Pritchard, L. A. Chodosh, P. L. Pfeffer, G. J. Lindeman, J. E. Visvader, C. J. Ormandy. Genes Dev 2008; 22 (5): 581–586. Abstract of the original article: Hormonal cues regulate mammary development, but the consequent transcriptional changes and cell fate decisions are largely undefined. We show that knockout of the prolactin-regulated Ets transcription factor Elf5 prevented formation of the secretory epithelium during pregnancy. Conversely, overexpression of Elf5 in an inducible transgenic model caused alveolar differentiation and milk secretion in virgin mice, disrupting ductal morphogenesis. CD61+ luminal progenitor cells accumulated in Elf5-deficient mammary glands and were diminished in glands with Elf5 overexpression. Thus Elf5 specifies the differentiation of CD61+ progenitors to establish the secretory alveolar lineage during pregnancy, providing a link between prolactin, transcriptional events, and alveolar development.

The anatomy and histology of the normal retrocalcaneal bursa (RB) was studied on both embalmed and fresh cadaverous material. The bursa is a constant structure, its upper and posterior walls are completely covered with the unilayered synovial membrane. Its anterior wall represents the superior facet of the calcaneal tuberosity, the posterior one corresponds to the anterior surface of the insertional part of the Achilles tendon. The superior wall is formed by the adipose tissue of the inferior part of Kager's triangle, extending into the cavity of the bursa in a form of constant large and irregularly shaped synovial fold. The normal anatomical features as well as some pathological changes of the bursa and its neighbourhood were demonstrated on examples of some case reports, by use of the ultrasonography and magnetic resonance investigations. In healthy individuals the space of the bursa was not figured in the ultrasonographic investigations, but was well apparent in the MR images. The pathological changes of the bursa are detectable by using of both methods, but the MR images present substantially precise quality of depiction. The authors recommend the use of presented new anatomical data for the improvement in differential diagnostic of the wide spectrum of achillar enthesopathies.