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Background: the treatment of infected non-union to allow for bony healing following orthopedic surgery remains a challenge. Antibiotic-impregnated calcium sulfate (AICS) is an effective vehicle for antibiotic delivery, but its efficacy in treating infected non-union in the setting of trauma and fracture remains unclear. Methods: this systematic review analyses nine studies from 2002 to 2022 that investigated AICS as a local antibiotic delivery system for cases of fracture-related infection and infected non-union. Results: in total, 214 patients who received AICS were included in this review. Of these patients, there were 154 cases of infected non-union or fracture-related infection. Across all studies analyzed, patients treated concurrently with AICS and systemic antibiotics experienced a 92.9 % rate of bony union and a 95.1 % rate of infection eradication. In addition, 100 % of the 13 patients who were treated with AICS alone experienced eradication of infection and successful bony union. Conclusion: AICS is an effective method of antibiotic delivery with a low risk profile that results in high rates of bony union and infection eradication even when used in the absence of systemic antibiotics.

Netrin 1 (Ntn1) is a cell migration protein with an anti-inflammatory effect, which may play a key role in the pathological development of type 2 diabetes (T2D). In this study, we evaluate the relationships between the serum concentrations of Ntn1, glucose, and high-sensitivity C-reactive Protein (hsCRP). We carried out a cross-sectional study including 90 individuals divided into three groups (n = 30): healthy subjects, individuals with obesity without glucose alterations, and individuals with newly diagnosed T2D. Serum concentrations of Ntn1 and hs-CRP were determined by enzyme-linked immunosorbent assay (ELISA). The serum concentration of Ntn1 was higher in individuals with newly diagnosed T2D (0.33 ± 0.22 ng/mL), in comparison to healthy subjects and individuals with obesity (0.13 ± 0.06 and 0.15 ± 0.07 ng/mL, respectively). In addition, we observed a positive association between the levels of Ntn1 and hsCRP (rho = 0.443; p < 0.001) as well as with serum glucose (rho = −0.110; p = 0.05). The serum concentration of Ntn1 was higher in individuals with T2D, in comparison with the other groups in this study, and presented a positive correlation with hsCRP. Therefore, Ntn1 can be considered a promising risk biomarker and a potential therapeutic target for T2D.

Reproductive technologies can help to protect wild ruminant species from becoming extinct. In addition, the decline in some wild game species has also raised interest in reproductive technologies to increase the number of animals that can be produced. Most biobanking efforts have focused on developing effective protocols for preserving sperm, oocytes, and embryos. Cryopreservation of sperm remains the least invasive method and the cheapest procedure for germplasm storage. Over the last few years, several reproductive biotechnologies have been developed beyond the conventional freezing of spermatozoa. These include ultra-rapid freezing techniques. Nevertheless, fertility results after artificial insemination using frozen-thawed spermatozoa are not always acceptable in wild small ruminants. Moreover, these technological efforts have met variable success related to the sample's origin (epididymal retrieved postmortem or ejaculated) and the season of sperm sample collection and storage. Epididymal sperm shows higher cryoresistance than ejaculated sperm. Changes in sperm proteome between epididymal and ejaculated sperm seem to contribute to this different cryotolerance. The role of endocrine status has been studied in some wild species to better understand the underlying mechanism of the annual variation in ruminant sperm cryoresistance. Seasonal changes in testosterone and prolactin are involved in sperm cryoresistance; sperm recovery and cryopreservation are recommended around the end of the rutting season, when good quality sperm samples can still be obtained, testosterone levels have already decreased, and prolactin concentrations remain low. The mechanisms of hormone action on sperm freezability are not well known. Still, it has been suggested that testosterone affects cell proliferation in the testis, during spermatogenesis, and membrane properties of sperm cells during their transit through the reproductive tract, which might influence their cryotolerance. Recent studies have revealed that the expression of aquaporins in the sperm cells of small wild ruminants could also be involved in the androgen-related seasonal variation of sperm cryoresistance. Along with epididymal and ejaculated spermatozoa, the cryopreservation of testicular tissue may provide a suitable source of male gametes, becoming an alternative for establishing germplasm banks when semen cannot be collected for whatever reason.

El ms. 154 de El Burgo de Osma, el primero conocido del Fortalitium fidei de Alonso de Espina, contiene una serie de representaciones relacionadas con distintas guerras libradas entre cristianos y musulmanes a lo largo de la Historia, en su mayoría desconocidas hasta ahora. Este artículo propone el análisis iconográfico de esa iluminación, y su encuadre en el estudio de la iconografía bélica desarrollada al final de la Edad Media en la península ibérica. El interés preferente de este trabajo se centra en las escenas de batalla, así como en la complementaria relación entre textos e imágenes que originan las narraciones plásticas del conflicto, y que, en su caso, nos ayudan a su identificación y contextualización historiográfica.

Introducción: Las metástasis cerebrales (MC) representan una problemática importante de la salud pública, en promedio el 30% de los pacientes oncológicos desarrollarán MC siendo importante causa de morbilidad, ansiedad y mortalidad. El tratamiento con radioterapia, cirugía y sistémico son los pilares para el tratamiento y han tenido una evolución importante en la última década. Propósito de la revisión: Se proporciona información actualizada en relación a epidemiología, diagnóstico, pronóstico y tratamiento de metástasis cerebrales desde un enfoque multidisciplinario para lograr individualizar su abordaje con el objetivo de proporcionar control oncológico y calidad de vida. También se discuten el acceso a nuevas terapias sistémicas, técnicas quirúrgicas y disponibilidad de tecnología para ofrecer técnicas avanzadas de radioterapia. Mensaje principal: Conocer mutaciones específicas y receptores diana de los tumores permite elegir quimio-inmunoterapia o terapias dirigidas actuales que ofrecen mejor potencial de control tanto a nivel sistémico como intracraneal. La secuenciación de los tratamientos sistémicos y locales (cirugía, radiocirugía, radioterapia holocraneal) deben ser discutidos desde un enfoque multidisciplinario. Conclusión: Es importante poder estimar el pronóstico de los pacientes con MC, esto determinará la conducta terapéutica que puede variar desde cuidados sintomáticos hasta tratamientos más agresivos como resección neuroquirúrgica o radiocirugía.

ABSTRACT Widely available and reliable testing for SARS-CoV-2 is essential for the public health response to the COVID-19 pandemic. We estimated the diagnostic performance of reverse transcription PCR (RT-PCR) performed on saliva and the SD Biosensor STANDARD Q antigen test performed on nasopharyngeal swab compared to the reference standard, nasopharyngeal swab (NP) RT-PCR. We enrolled participants living and/or seeking care in health facilities in North Lima, Peru from November 2020 to January 2021. Consenting participants underwent same-day RT-PCR on both saliva and nasopharyngeal swab specimens, antigen testing on a nasopharyngeal swab specimen, pulse oximetry, and standardized symptom assessment. We calculated sensitivity, specificity, and predictive values for the nasopharyngeal antigen and saliva RT-PCR compared to nasopharyngeal RT-PCR. Of 896 participants analyzed, 567 (63.3%) had acute signs/symptoms of COVID-19. The overall sensitivity and specificity of saliva RT-PCR were 85.8% and 98.1%, respectively. Among participants with and without acute signs/symptoms of COVID-19, saliva sensitivity was 87.3% and 37.5%, respectively. Saliva sensitivity was 97.4% and 56.0% among participants with cycle threshold (CT) values of ≤30 and >30 on nasopharyngeal RT-PCR, respectively. The overall sensitivity and specificity of nasopharyngeal antigen were 73.2% and 99.4%, respectively. The sensitivity of the nasopharyngeal antigen test was 75.1% and 12.5% among participants with and without acute signs/symptoms of COVID-19, and 91.2% and 26.7% among participants with CT values of ≤30 and >30 on nasopharyngeal RT-PCR, respectively. Saliva RT-PCR achieved the WHO-recommended threshold of >80% for sensitivity for the detection of SARS-CoV-2, while the SD Biosensor nasopharyngeal antigen test did not. IMPORTANCE In this diagnostic validation study of 896 participants in Peru, saliva reverse transcription PCR (RT-PCR) had >80% sensitivity for the detection of SARS-CoV-2 among all-comers and symptomatic individuals, while the SD Biosensor STANDARD Q antigen test performed on nasopharyngeal swab had 80% sensitivity.

Introduction Patients with mild cognitive impairment may present deficits in naming, speech production, oral comprehension and written comprehension. In the differential diagnosis, cerebrovascular disease that can lead to cognitive impairment must also be differentiated from endogenous depressive disorder or language impairment. Objectives The aim is to highlight the importance of differential diagnosis in cognitive disorders in relation to a case. Methods A 68-year-old female patient attended a psychiatric consultation derived from neurology when presenting a language disorder. The husband who accompanies her and the patient indicate that she has problems finding words and substitutes other expressions for them or sometimes does not answer or does so with something different from the topic that is being asked. She refers that she presents repetitive language with memory problems, alteration in the evocation of memories. The patient reports mood swings and irritability and crying with a low tolerance for frustration since she cannot express herself. Cranial MRI: cortical and central involutional changes. Periventricular leukoaraiosis and ischemic gliosis-like lesions in the white matter of both hemispheres. Psychopathological exploration: Conscious, oriented. She smiles at the questions but doesn’t answer them. Repetitive language. Alteration in the articulation of language. Depressed mood reactive to current situation. Some irritability Alteration in recent memory and evocation. Results She was diagnosed with organic mental disorder compatible with mild cognitive impairment. Treatment with rehabilitation of the language disorder of vascular etiology is established. Conclusions Imaging and neuropsychological tests should always be performed in a patient with language, memory, and mood disorders to study its etiology. Disclosure No significant relationships.

Recent reports showed a positive correlation between frozen–thawed rooster sperm DNA integrity and the concentrations of valine in seminal plasma. The present study evaluated the effect of supplementing valine to semen extender for freezing sperm of 2 endangered local Spanish chicken breeds with different sperm cryoresistance: Red Villafranquina (VF) showing low sperm DNA integrity after cryopreservation and Quail Castellana that shows higher DNA integrity. One pool of semen per breed was obtained twice a week for 10 wk (n = 40, 20 per breed). Each pool was divided into 2 fractions. One of these fractions was frozen in presence of valine as additive in the extender (concentration 10 mmol), whereas the other was used as control. The evaluation of the samples before and after freezing-thawing included motility (CASA-Mot system), viability (propidium iodide and SYBR-14), DNA integrity (terminal deoxynucleotidyl transferase dUTP nick end labeling), and fertility rate (percentage of eggs with blastoderm development after artificial insemination). Supplementation of valine increased several motility variables of fresh semen. In VF breed, valine increased percentage of progressive motile sperm (P = 0.025), curvilinear velocity (P = 0.033), straight-line velocity (P = 0.040), and average path velocity (P = 0.033), whereas progressive motile sperm (P = 0.019), curvilinear velocity (P = 0.006), straight-line velocity (P = 0.003) and average path velocity (P = 0.004) were improved in the Quail Castellana breed. Valine addition increased the DNA integrity of cryopreserved semen (decreased post-thaw DNA fragmentation) in both breeds, with a significant effect (P = 0.002) in VF (36.3% VF-control vs 31%VF-valine). As expected, Quail Castellana cryopreserved sperm control showed higher fertility rate (34.4% ± 12.1) than VF cryopreserved sperm control (16.1% + 6.2). Supplementing valine to the freezing extender doubled (P = 0.026) the fertility rate of VF (32.6% ± 12.2) compared with the control (16.1% + 6.2). In conclusion, supplementation of valine to chicken freezing extenders shows a positive effect on DNA fragmentation and fertilizing ability of frozen–thawed sperm, with a better response in a breed considered as the lowest freezer in our conservatory.

La literatura reglar generada por las órdenes militares de Calatrava y Santiago contiene información relevante para estudiar muchos aspectos de su organización, entre ellos algunos que nos explican su vínculo fundamental con la guerra. Este trabajo busca realizar un estudio comparativo de ese corpus textual formado por reglas, estatutos, definiciones, actas capitulares y establecimientos de las dos principales órdenes hispanas, para conocer mejor el carisma bélico que estas instituciones tuvieron. Por otro lado, se podrán trazar paralelos o divergencias entre una y otra, además de ayudarnos a medir la importancia que la actividad bélica tuvo para ellas.

Abstract Background Only 40–60% of patients with generalized anxiety disorder experience long-lasting improvement with gold standard psychosocial interventions. Identifying neurobehavioral factors that predict treatment success might provide specific targets for more individualized interventions, fostering more optimal outcomes and bringing us closer to the goal of “personalized medicine.” Research suggests that reward and threat processing (approach/avoidance behavior) and cognitive control may be important for understanding anxiety and comorbid depressive disorders and may have relevance to treatment outcomes. This study was designed to determine whether approach-avoidance behaviors and associated neural responses moderate treatment response to exposure-based versus behavioral activation therapy for generalized anxiety disorder. Methods/design We are conducting a randomized controlled trial involving two 10-week group-based interventions: exposure-based therapy or behavioral activation therapy. These interventions focus on specific and unique aspects of threat and reward processing, respectively. Prior to and after treatment, participants are interviewed and undergo behavioral, biomarker, and neuroimaging assessments, with a focus on approach and avoidance processing and decision-making. Primary analyses will use mixed models to examine whether hypothesized approach, avoidance, and conflict arbitration behaviors and associated neural responses at baseline moderate symptom change with treatment, as assessed using the Generalized Anxiety Disorder–7 item scale. Exploratory analyses will examine additional potential treatment moderators and use data reduction and machine learning methods. Discussion This protocol provides a framework for how studies may be designed to move the field toward neuroscience-informed and personalized psychosocial treatments. The results of this trial will have implications for approach-avoidance processing in generalized anxiety disorder, relationships between levels of analysis (i.e., behavioral, neural), and predictors of behavioral therapy outcome. Trial registration The study was retrospectively registered within 21 days of first participant enrollment in accordance with FDAAA 801 with ClinicalTrials.gov, NCT02807480. Registered on June 21, 2016, before results.

Over the last century, several reproductive biotechnologies beyond the artificial incubation of eggs were developed to improve poultry breeding stocks and conserve their genetic diversity. These include artificial insemination (AI), semen storage, diploid primordial germ cell (PGC) methodologies, and gonad tissue storage and transplantation. Currently, AI is widely used for selection purposes in the poultry industry, in the breeding of turkeys and guinea fowl, and to solve fertility problems in duck interspecies crosses for the production of mule ducklings. The decline in some wild game species has also raised interest in reproductive technologies as a means of increasing the production of fertile eggs, and ultimately the number of birds that can be raised. AI requires viable sperm to be preserved in vitro for either short (fresh) or longer periods (chilling or freezing). Since spermatozoa are the most easily accessed sex cells, they are the cell type most commonly preserved by genetic resource banks. However, the cryopreservation of sperm only preserves half of the genome, and it cannot preserve the W chromosome. For avian species, the problem of preserving oocytes and zygotes may be solved via the cryopreservation and transplantation of PGCs and gonad tissue. The present review describes all these procedures and discusses how combining these different technologies allows poultry populations to be conserved and even rapidly reconstituted.

ABSTRACT The objective of the study was to determine whether or not there is a correlation between thermoresistance tests (TT) after semen thawing and pregnancy rate (PR) after fixed-time artificial insemination (FTAI). Four different TT were performed on ten samples used for AI; a rapid test (RTT) (30min / 46°C) and three slow tests (STT): STT1 (60min/38°C), STT2 (180min/38°C), and STT3 (300min/38°C). Two hundred and fifteen multiparous crossbred cows were submitted to FTAI under the following protocol: on day zero (d0) the animals received a P4 device +EB; on d7 PGF2α; on d8 P4 was removed and eCG+EC were administered; IATF was performed on d10. Three gestational diagnoses (G D) were performed on d40, d70 and d120. The mean sperm motility (%) in RTT and STTs were 19.84±6.13, 28.55±10.48, 17.62±5.87 and 8.63±3.46, respectively, and TP in the three DG 61.86%, 57.67%, and 55.81%, respectively. Through Person test a significant negative correlation (P< 0.05) was found between STT2 and PR at 60 days (r= -0.644) and between STT3 and all TPs (r= -0.774, -0.752, 0.748). It was concluded that TT parameters are not able to determine correlation between semen quality and TP.

Abstract We review the physics opportunities of the Future Circular Collider, covering its e+e-, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics.

Las órdenes militares hispanas, a pesar de su modesta contribución numérica, tuvieron un indudable protagonismo en la guerra fronteriza contra el islam, y cada vez son más los estudios dedicados exclusivamente a tratar esta función esencial. Sin embargo, existen algunos presupuestos sobre su capacidad militar que conviene matizar y complejizar. Este trabajo busca analizar la cualificación militar de los ejércitos de las órdenes, para determinar si tuvieron específicas capacidades operativas, cuál fue su eficacia real en el combate y qué imagen positiva proyectaron en torno a su papel en la materialización de la ideología de la reconquista.

Abstract We compute all the tree-level contributions to the Wilson coefficients of the dimension-six Standard-Model effective theory in ultraviolet completions with general scalar, spinor and vector field content and arbitrary interactions. No assumption about the renormalizability of the high-energy theory is made. This provides a complete ultraviolet/infrared dictionary at the classical level, which can be used to study the low-energy implications of any model of interest, and also to look for explicit completions consistent with low-energy data.

Abstract Timothy syndrome type 1 (TS1), a malignant variant of Long QT Syndrome, is caused by L-type Ca2+ Channel (LTCC) inactivation defects secondary to the p.Gly406Arg mutation in the CACNA1C gene. Leveraging on the experimental in vitro data from our TS1 knock-in swine model and their wild-type (WT) littermates, we first developed a mathematical model of WT large white swine ventricular cardiomyocyte electrophysiology that reproduces a wide range of experimental data, including ionic current properties, action potential (AP) dynamics, and $$\hbox {Ca}^{2+}$$ Ca 2 + handling. A sensitivity analysis tested robustness and facilitated comparison with the parent ORd human model. Introducing 22% of TS1-mutated LTCCs, the model faithfully reproduced key disease features, including marked AP prolongation, steeper rate-dependent adaptation of AP duration, $$\hbox {Ca}^{2+}$$ Ca 2 + overload, and CaMKII-mediated decreased upstroke velocity. Translational relevance of the TS1 model was investigated by: dissecting the roles of primary and secondary contributors to TS1 phenotype; demonstrating the arrhythmogenic potential of TS1 vs. WT cells; and evaluating the model’s capability to identify novel pharmacological targets which could modulate the cellular phenotype. In conclusion, we developed a mathematical large white swine ventricular myocyte model, demonstrating its utility in exploring arrhythmogenic mechanisms and therapeutic interventions in cardiac diseases, such as TS1.

Background. Adenoviruses are highly contagious pathogens which cause respiratory disease particularly in children; they may induce severe disease in infants. Human neutrophil peptides (HNPs) have been found to exhibit antiadenoviral activity. Thus, we have investigated HNPs in nasal aspirates (NAs) of children suffering from adenoviral common cold. Objective. To investigate the release of HNP-1–4 in adenovirus infection and the relationship with self-limiting upper respiratory tract infections. Methods. Nasal aspirate samples (n=14) were obtained from children (aged 6–12 years) infected with adenovirus between June 2012 and December 2015. Control samples were taken 4 weeks after infection when the children were asymptomatic. Levels of HNPs were measured using an enzyme-linked immunosorbent assay (ELISA). Results. There were increased levels of HNP-1, -3, and -4, but not HNP-2, in nasal aspirates (NAs) during adenovirus infections compared to healthy specimens (p≤0.01). Moreover, there was also increase in the neutrophil count, which is a known cell source of HNPs. Conclusion. Our finding supports the involvement of HNP-1, -3, and -4 in naturally occurring cold in children infected with adenovirus. Because of their known antiviral properties, it is tempting to hypothesize that HNPs might play a protective role in adenovirus-induced respiratory disease; however, this remains to be shown.

Fields of dislodged boulders and blocks record catastrophic coastal flooding during strong storms or tsunamis and play a pivotal role in coastal hazard assessment. Along the rocky carbonate coast of Eastern Samar (Philippines) we documented longshore transport of a block of 180 t and boulders (up to 23.5 t) shifted upslope to elevations of up to 10 m above mean lower low water level during Supertyphoon Haiyan on 8 November 2013. Initiation-of-motion approaches indicate that boulder dislocation occurred with flow velocities of 8.9–9.6 m s−1, which significantly exceeds depth-averaged flow velocities of a local coupled hydrodynamic and wave model (Delft3D) of the typhoon with a maximum < 1.5 m s−1. These results, in combination with recently published phase-resolving wave models, support the hypothesis that infragravity waves induced by the typhoon were responsible for the remarkable flooding pattern in Eastern Samar, which are not resolved in phase-averaged storm surge models. Our findings show that tsunamis and hydrodynamic conditions induced by tropical cyclones may shift boulders of similar size and, therefore, demand a careful re-evaluation of storm-related transport where it, based on the boulder's sheer size, has previously been ascribed to tsunamis.

Super Typhoon Haiyan entered the Philippine Area of Responsibility (PAR) on 7 November 2013, causing tremendous damage to infrastructure and loss of lives mainly due to the storm surge and strong winds. Storm surges up to a height of 7 m were reported in the hardest hit areas. The threat imposed by this kind of natural calamity compelled researchers of the Nationwide Operational Assessment of Hazards (Project NOAH) which is the flagship disaster mitigation program of the Department of Science and Technology (DOST) of the Philippine government to undertake a study to determine the vulnerability of all Philippine coastal communities to storm surges of the same magnitude as those generated by Haiyan. This study calculates the maximum probable storm surge height for every coastal locality by running simulations of Haiyan-type conditions but with tracks of tropical cyclones that entered PAR from 1948–2013. One product of this study is a list of the 30 most vulnerable coastal areas that can be used as a basis for choosing priority sites for further studies to implement appropriate site-specific solutions for flood risk management. Another product is the storm tide inundation maps that the local government units can use to develop a risk-sensitive land use plan for identifying appropriate areas to build residential buildings, evacuation sites, and other critical facilities and lifelines. The maps can also be used to develop a disaster response plan and evacuation scheme.

A storm surge is the sudden rise of sea water over the astronomical tides, generated by an approaching storm. This event poses a major threat to the Philippine coastal areas, as manifested by Typhoon Haiyan on 8 November 2013. This hydro-meteorological hazard is one of the main reasons for the high number of casualties due to the typhoon, with 6300 deaths. It became evident that the need to develop a storm surge inundation map is of utmost importance. To develop these maps, the Nationwide Operational Assessment of Hazards under the Department of Science and Technology (DOST-Project NOAH) simulated historical tropical cyclones that entered the Philippine Area of Responsibility. The Japan Meteorological Agency storm surge model was used to simulate storm surge heights. The frequency distribution of the maximum storm surge heights was calculated using simulation results of tropical cyclones under a specific public storm warning signal (PSWS) that passed through a particular coastal area. This determines the storm surge height corresponding to a given probability of occurrence. The storm surge heights from the model were added to the maximum astronomical tide data from WXTide software. The team then created maps of inundation for a specific PSWS using the probability of exceedance derived from the frequency distribution. Buildings and other structures were assigned a probability of exceedance depending on their occupancy category, i.e., 1% probability of exceedance for critical facilities, 10% probability of exceedance for special occupancy structures, and 25% for standard occupancy and miscellaneous structures. The maps produced show the storm-surge-vulnerable areas in Metro Manila, illustrated by the flood depth of up to 4 m and extent of up to 6.5 km from the coastline. This information can help local government units in developing early warning systems, disaster preparedness and mitigation plans, vulnerability assessments, risk-sensitive land use plans, shoreline defense efforts, and coastal protection measures. These maps can also determine the best areas to build critical structures, or at least determine the level of protection of these structures should they be built in hazard areas. Moreover, these will support the local government units' mandate to raise public awareness, disseminate information about storm surge hazards, and implement appropriate countermeasures for a given PSWS.

IntroductionContinuous renal replacement therapy (CRRT) is used for the symptomatic management of acute kidney injury (AKI) and fluid overload (FO). Contemporary reports on pediatric CRRT are small and single center in design. Large international studies evaluating CRRT practice and outcomes are lacking. Herein, we describe the design of a multinational collaborative.MethodsThe Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK) is an international collaborative of pediatric specialists whose mission is to improve short- and long-term outcomes of children treated with CRRT. The aims of this multicenter retrospective study are to describe the epidemiology, liberation patterns, association of fluid balance and timing of CRRT initiation, and CRRT prescription with outcomes.ResultsWe included children (n = 996, 0-25 years) admitted to an intensive care unit (ICU) and treated with CRRT for AKI or FO at 32 centers (in 7 countries) from 2018 to 2021. Demographics and clinical characteristics before CRRT initiation, during the first 7 days of both CRRT, and liberation were collected. Outcomes include the following: (i) major adverse kidney events at 90 days (mortality, dialysis dependence, and persistent kidney dysfunction), and (ii) functional outcomes (functional stats scale).ConclusionThe retrospective WE-ROCK study represents the largest international registry of children receiving CRRT for AKI or FO. It will serve as a broad and invaluable resource for the field of pediatric critical care nephrology that will improve our understanding of practice heterogeneity and the association of CRRT with clinical and patient-centered outcomes. This will generate preliminary data for future interventional trials in this area.

Introduction In 2020, the American Osteopathic Association merged its residency programs into one system under the Accreditation Council for Graduate Medical Education (ACGME). The effects of this transition on the ophthalmology match is not fully understood. The purpose of this study is to assess the early impact of the transition to ACGME accreditation on MD, DO, and IMG representation in ophthalmology residency programs.Materials and Methods Information about resident medical degree and resident medical school was gathered from ophthalmology residency program websites from a resident class before and after the Transition. Additionally, the medical degree of residency program directors (PD) was collected to analyze MD vs DO leadership in ophthalmology residency programs and to further stratify resident data to identify any trends in PD preference for different medical graduates.Results Data was obtained for 915 ophthalmology residents in 110 residency programs that met the study’s inclusion criteria. Of these programs, 102 were allopathic with MD leadership, 1 was allopathic with DO leadership, 3 were osteopathic with MD leadership, and 4 were osteopathic with DO leadership. Overall, MD representation increased while DO and IMG representation decreased although not significantly. For both classes analyzed, DO and IMG representation was disproportionately low.Discussion The transition to ACGME accreditation seems to have primarily harmed DO and IMG applicants in the ophthalmology match while benefitting MDs. Various factors such as loss of protected residency positions for DO applicants and the closure of osteopathic ophthalmology residency programs are likely reasons to blame for this decrease in osteopathic representation.

We developed a technique to identify and estimate the size, intensity, and Tropopause overshoot of thunderstorm convective cores expected to be significant sources of gravity waves. The work was based on GOES IR images of South America on the night of 30 September to 1 October and 25–26 October 2005, as part of the Spread F Experiment (SpreadFEx) in Brazil in 2005. We also characterized, for the first time, the convective activity of three small TLE producing thunderstorms that yielded 11 TLEs on 25–26 October 2005. The campaign occurred during the dry to wet season transition in central Brazil, marked by the presence of extra-tropical cyclogenesis over the Atlantic Ocean, and cold fronts penetrating inland. The Tropopause temperature was typically −76°C with a corresponding altitude of ~15 200 m. Vigorous convective cores capable of generating strong gravity waves were located in convective regions having areas with cloud top temperatures ≤−76°C. They had typical cloud-top temperature deficits of ΔT−2.0°C to −8.0°C from the average surroundings, implying overshoot heights of 200 to 3100 m, which are within the typical range. Fast vertical development and high horizontal growth rates were associated with a large number of simultaneously active vigorous convective cores, indicating that their dynamics may have determined the spatial-temporal development of the thunderstorms analyzed. Moderate convective cores were also present in areas with cloud top −76°C≤T≤−70°C. They had ΔT of −1.9°C to −5.3°C producing overshoots between 80–300 m. All convective cores had typical diameters of 5–20 km and their size tended to increase with ΔT, there was a 57% correlation between the two parameters. Analysis of the relationship of cloud top T with positive and negative cloud-to-ground lightning (+/−CG) occurrence rate and with peak current showed that lighting activity may provide an independent way to identify convective cores and measure their intensity, since they were characterized by a high incidence of low peak current −CGs that forms the bulk of the −CG population.

El presente trabajo trata de dar a conocer la vida y la actividad de los profesionales de la Botica de un emblemático hospital español durante el siglo XVIII. Este Centro sanitario, fundado por los Reyes Católicos en las postrimerías del siglo XV, dotará a los profesionales de la Botica de unas originales Constituciones que regularán la vida de estos más allá de su tarea farmacéutica. El autor intenta recrear la figura de los Boticarios de la Institución en su vertiente profesional y la que deriva de ésta en el conjunto de la sociedad urbana de su época; para ello se estudian, en distintas secciones, las obligaciones de los Boticarios en tanto que técnicos del medicamento y en su condición de Ministros Mayores del Establecimiento, su engranaje en el entramado sanitario del Centro y los conflictos que aparecen entre los diversos estamentos, su formación, sus sueldos —que se comparan con el de otros profesionales afines y aún con los de otros Hospitales españoles de similares características—, los criterios de su nombramiento así como el origen y la consideración social que su cargo les depara.

Se revisan algunas de las características más importantes de la fisiología reproductiva de la oveja, especialmente en razas estacionales y más meridionales, afectadas principalmente por factores ambientales. Se discute la adecuada utilización de los sistemas de inducción de la actividad reproductiva, con el fin de mejorar los rendimientos de productividad en dichas razas. Se incluye la explicación fisiológica de estacionalidad y efecto del foto período, períodos de inhibición reproductiva (anestro estacional y de lactación) y reinicio de la actividad cíclica ovárica posparto, al igual que se enfatizan algunos conceptos recientes sobre la regulación del desarrollo folicular, ovulación, luteólisis y reconocimiento maternal.

Sheep and goat breeds from subtropical, middle and high latitudes show seasonal changes in reproductive activity. In general, the breeding season starts in autumn and ends in winter, with anoestrus in spring/summer. An endogenous circannual rhythm driven and synchronised by the annual photoperiod cycle regulates the onset and offset of the breeding season. However, the timing and duration of the breeding season can be affected by interactions between the photoperiod and factors such as breed, geographical origin, nutritional and lactational status, social interactions, and the season of parturition. Seasonality in reproduction is naturally accompanied by variation in the availability and price of meat, milk and cheese over the year, affecting the economy of farmers, consumers and the food industry alike. The control of reproduction outside the normal breeding season by inducing and synchronizing oestrus and ovulation plus the use of artificial insemination and/or natural mating would help ensure the year-round availability of products. This review describes the seasonal variation in the sexual activity of ovine and caprine species with special regard to local Spanish sheep and goats breeds, examines how the photoperiod regulates their annual reproductive cycle, and discusses a number of strategies that can be used to induce and synchronise ovulation outside the natural breeding season.

El estudio de las capacidades operativas de la arquitectura militar medieval va poniendo de manifiesto que sus posibilidades funcionales son muy amplias, actuando como elementos organizadores del territorio, de sus recursos y de los hombres que lo ocupan; desarrollando unas innegables capacidades simbólicas o representativas; y, por supuesto, representando un papel militar del que nunca estuvieron exentas. Un aspecto concreto de esa realidad funcional, sin embargo, nos parece que aún no ha sido estudiado sistemáticamente, nos referimos al hecho frecuente de que algunos castillos se conviertan en herramienta básica para contrarrestar, debilitar y, finalmente, conquistar a otras fortalezas de su entorno más o menos inmediato, sirviendo como recurso de los ejércitos medievales en sus campañas de ocupación y conquista. En torno a lo que podemos llamar genéricamente fortificaciones de asedio y bloqueo, y en concreto en torno a una tipología específica de ellas que constituyeron los “padrastros” va a girar, por ende, el presente trabajo dedicado a poner de relieve esta parte del protagonismo ofensivo que tuvo la arquitectura militar en diferentes contextos bélicos durante la Edad Media peninsular.

En torno a las fortalezas se desarrollaron muchos de los episodios bélicos del secular enfrentamiento medieval entre el Islam y la Cristiandad. En las fronteras orientales y occidentales de estos dos mundos, la arquitectura militar se convirtió en objetivo prioritario de la guerra, al tiempo que constituían bases seguras desde las que operar contra el enemigo. El trabajo que presentamos nos permite acercarnos a la compleja realidad funcional de estos castillos a la vanguardia de la Guerra Santa, recurriendo para ello a diversos ejemplos de la realidad fronteriza en la Península Ibérica y en Tierra Santa.In connection witti thíe fortresses were developed many warlike episodes of the secular medieval confrontation among tfie Islam and the Christendom. In the western and eastern frontiers of these two worlds, the militan/ architecture was converted in a high-priority objective of the war, to the time that constituted secure bases from those which to opérate against the enemy. The work that we present allow us an approach to the complex functional reality of these castles to the forefront of the Holy War, appealing for this to various examples of the Holy Land and the Iberian península border reality.

"El presente es el primero de una serie de artículos destinados a la divulgación de un tema que no está muy difundido en nuestro medio, pero que sin embargo es un tema de gran interés, no sólo desde el punto de vista fundamental sino también económico. Se trata de los cristales líquidos, los cuales son materiales que poseen propiedades intermediarias entre las de los sólidos y las de los líquidos, y que constituyen un nuevo estado de la materia. En este artículo se presenta una breve reseña histórica sobre el descubrimiento de los cristales líquidos, para luego pasar a describirlos y diferenciarlos de los sólidos y líquidos, tomando como referencia el orden molecular al interior de estos tres estados de la materia. Igualmente se dan diferentes clasificaciones basadas en tres criterios: a)medio empleado para los cambios de fase (temperatura: CL termotrópicos, y cambio de concentración: CL liotrópicos), b) reversibilidad de las transiciones de fase (enantiotrópicos: reversible, y monotrópicos: solamente durante el enfriamiento), y c) forma de las moléculas que conforman el material (calamíticos: forma de varilla, discóticos: forma de disco, etc.). Se discuten los requerimientos estructurales que deben poseer las moléculas para poder exhibir propiedades cristales líquidas o mesomorfas. Finalmente, se citan las propiedades físicas que hacen que estos materiales tengan gran aplicación en la fabricación de una gran variedad de pantallas digitales."

El propósito de este trabajo consiste en ofrecer una síntesis en torno al valor de las imágenes como elementos capaces de transmitir mensajes culturales y políticos complejos dentro de la sociedad medieval, y más concretamente en relación a la génesis, desarrollo y difusión de algunos conceptos asociados a las ideas de cruzada y reconquista en el ámbito hispano. Para ello, se analizan los principales elementos que participan en dicho proceso de comunicación (emisor, receptor, mensaje, código y canal etc.), un intercambio de información que, durante la Edad Media, estuvo fundamentado en la imagen y los símbolos más que en los textos o la palabra, y que es posible analizar a partir de los numerosos testimonios artísticos y plásticos que conservamos de aquel periodo. La principal conclusión que se desprende del estudio de este proceso de comunicación, incide en la importancia que los mensajes visuales tuvieron, dentro de una sociedad prácticamente ágrafa, en la transmisión de una ideología combativa contra el Islam andalusí basada en argumentos religiosos pero también culturales, políticos e históricos.

No abstract available.

In the United States, youth aged 13-24 comprised approximately 21% of new HIV infections in 2017; 13% of these infections occurred among women, the majority of whom (86%) acquired HIV through heterosexual contact (Centers for Disease Control and Prevention. 2019a. HIV and youth. Retrieved from https://www.cdc.gov/hiv/group/age/youth/index.html, Centers for Disease Control and Prevention. 2019b. HIV among women. Retrieved from https://www.cdc.gov/hiv/group/gender/women/index.html). We fit and validated a developmentally appropriate empirical model of Connell's Theory of Gender and Power (Connell, R. W. 1987. Gender and power: Society, the person and sexual politics. Stanford, CA: Stanford University Press, Connell, R. W. 2013. Gender and power: Society, the person and sexual politics. Hoboken, NJ: John Wiley & Sons) in a sample of young women and assessed whether gendered powerlessness reflected a multidimensional higher-order latent factor, as the theory implies. Anonymous computer-assisted interviews were administered to at-risk, sexually active young women (N = 1,101). Factor analyses and structural equation modeling were used to determine the dimensionality of gendered powerlessness. Associations with condom use were examined to validate the model. We fit a three-component model of gendered powerlessness, but not a higher-order latent factor. We observed that high scores on two dimensions of gendered powerlessness - cathexis and sexual division of power - were associated with lower likelihood of condom use. Our three-component model helps elucidate the role that components of gendered powerlessness play in young women's health behaviors and underscores the need for measures tailored to young women at high risk of contracting HIV.

BackgroundPhosphatidylethanol (PEth) is a direct biomarker for alcohol that is formed shortly after alcohol use and may remain detectable in blood for weeks after alcohol consumption. There is little research on alcohol use factors that influence PEth elimination, especially among women.MethodsData were collected from 116 alcohol use-disordered women who were recently incarcerated. We used a 2-part model with logistic and linear components to examine whether alcohol consumption in the 2 weeks prior to incarceration and days since last alcoholic drink (operationalized as abstinence days prior to incarceration + days incarcerated) were associated with PEth detectability (>8 ng/ml) and level (ng/ml) in blood.ResultsParticipants reported drinking an average of 10 drinks per day in the 2 weeks prior to incarceration. Days since last drink was negatively associated with PEth level (odds ratio [OR] = 0.97, 95% confidence interval [CI] = 0.93; 0.99) and being PEth detectable (OR = 0.96, 95% CI = 0.91; 0.99). Quantity of alcohol consumed prior to jail admission was associated with PEth detection (OR = 1.08; 95% CI = 1.03; 1.16), but not PEth level.ConclusionsDays since last alcoholic drink and drinks per day both influenced PEth detectability, but only days since last drink predicted PEth level among a large sample of women with alcohol use disorder in the criminal justice system.