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Supplementary Table S1 from Pretreatment Transcriptional Profiling for Predicting Response to Neoadjuvant Chemoradiotherapy in Rectal Adenocarcinoma

Purpose: Patients presenting with locally advanced rectal cancer currently receive preoperative radiotherapy with or without chemotherapy. Although pathologic complete response is achieved for approximately 10% to 30% of patients, a proportion of patients derive no benefit from this therapy while being exposed to toxic side effects of treatment. Therefore, there is a strong need to identify patients who are unlikely to benefit from neoadjuvant therapy to help direct them toward alternate and ultimately more successful treatment options.Experimental Design: In this study, we obtained expression profiles from pretreatment biopsies for 51 rectal cancer patients. All patients underwent preoperative chemoradiotherapy, followed by resection of the tumor 6 to 8 weeks posttreatment. Gene expression and response to treatment were correlated, and a supervised learning algorithm was used to generate an original predictive classifier and validate previously published classifiers.Results: Novel predictive classifiers based on Mandard's tumor regression grade, metabolic response, TNM (tumor node metastasis) downstaging, and normal tissue expression profiles were generated. Because there were only 7 patients who had minimal treatment response (>80% residual tumor), expression profiles were used to predict good tumor response and outcome. These classifiers peaked at 82% sensitivity and 89% specificity; however, classifiers with the highest sensitivity had poor specificity, and vice versa. Validation of predictive classifiers from previously published reports was attempted using this cohort; however, sensitivity and specificity ranged from 21% to 70%.Conclusions: These results show that the clinical utility of microarrays in predictive medicine is not yet within reach for rectal cancer and alternatives to microarrays should be considered for predictive studies in rectal adenocarcinoma. Clin Cancer Res; 17(9); 3039–47. ©2011 AACR.

Background:\ud Greater understanding of international cancer survival differences is needed. We aimed to identify predictors and consequences of cancer diagnosis through emergency presentation in different international jurisdictions in six high-income countries.\ud \ud Methods:\ud Using a federated analysis model, in this cross-sectional population-based study, we analysed cancer registration and linked hospital admissions data from 14 jurisdictions in six countries (Australia, Canada, Denmark, New Zealand, Norway, and the UK), including patients with primary diagnosis of invasive oesophageal, stomach, colon, rectal, liver, pancreatic, lung, or ovarian cancer during study periods from Jan 1, 2012, to Dec 31, 2017. Data were collected on cancer site, age group, sex, year of diagnosis, and stage at diagnosis. Emergency presentation was defined as diagnosis of cancer within 30 days after an emergency hospital admission. Using logistic regression, we examined variables associated with emergency presentation and associations between emergency presentation and short-term mortality. We meta-analysed estimates across jurisdictions and explored jurisdiction-level associations between cancer survival and the percentage of patients diagnosed as emergencies.\ud \ud Findings:\ud In 857 068 patients across 14 jurisdictions, considering all of the eight cancer sites together, the percentage of diagnoses through emergency presentation ranged from 24·0% (9165 of 38 212 patients) to 42·5% (12 238 of 28 794 patients). There was consistently large variation in the percentage of emergency presentations by cancer site across jurisdictions. Pancreatic cancer diagnoses had the highest percentage of emergency presentations on average overall (46·1% [30 972 of 67 173 patients]), with the jurisdictional range being 34·1% (1083 of 3172 patients) to 60·4% (1317 of 2182 patients). Rectal cancer had the lowest percentage of emergency presentations on average overall (12·1% [10 051 of 83 325 patients]), with a jurisdictional range of 9·1% (403 of 4438 patients) to 19·8% (643 of 3247 patients). Across the jurisdictions, older age (ie, 75–84 years and 85 years or older, compared with younger patients) and advanced stage at diagnosis compared with non-advanced stage were consistently associated with increased emergency presentation risk, with the percentage of emergency presentations being highest in the oldest age group (85 years or older) for 110 (98%) of 112 jurisdiction-cancer site strata, and in the most advanced (distant spread) stage category for 98 (97%) of 101 jurisdiction-cancer site strata with available information. Across the jurisdictions, and despite heterogeneity in association size (I2=93%), emergency presenters consistently had substantially greater risk of 12-month mortality than non-emergency presenters (odds ratio >1·9 for 112 [100%] of 112 jurisdiction-cancer site strata, with the minimum lower bound of the related 95% CIs being 1·26). There were negative associations between jurisdiction-level percentage of emergency presentations and jurisdiction-level 1-year survival for colon, stomach, lung, liver, pancreatic, and ovarian cancer, with a 10% increase in percentage of emergency presentations in a jurisdiction being associated with a decrease in 1-year net survival of between 2·5% (95% CI 0·28–4·7) and 7·0% (1·2–13·0).\ud \ud Interpretation:\ud Internationally, notable proportions of patients with cancer are diagnosed through emergency presentation. Specific types of cancer, older age, and advanced stage at diagnosis are consistently associated with an increased risk of emergency presentation, which strongly predicts worse prognosis and probably contributes to international differences in cancer survival. Monitoring emergency presentations, and identifying and acting on contributing behavioural and health-care factors, is a global priority for cancer control.\ud \ud Funding:\ud Canadian Partnership Against Cancer; Cancer Council Victoria; Cancer Institute New South Wales; Cancer Research UK; Danish Cancer Society; National Cancer Registry Ireland; The Cancer Society of New Zealand; National Health Service England; Norwegian Cancer Society; Public Health Agency Northern Ireland, on behalf of the Northern Ireland Cancer Registry; the Scottish Government; Western Australia Department of Health; and Wales Cancer Network.

The astrophysical $S$-factor for the radiative proton capture reaction on $^7$Be ($S_{17}$) at low energies is affected by the $s$-wave scattering lengths. We report the measurement of elastic and inelastic scattering cross sections for the $^7$Be+p system in the center-of-mass energy range 0.474 - 2.740 MeV and center-of-mass angular range of 70$^\circ$- 150$^\circ$. A radioactive $^7$Be beam produced at Oak Ridge National Laboratory's (ORNL) Holifield Radioactive Ion Beam Facility was accelerated and bombarded a thin polypropylene (CH$_{2}$)$_\text n$ target. Scattered ions were detected in the segmented Silicon Detector Array. Using an $\textit{R}$-matrix analysis of ORNL and Louvain-la-Neuve cross section data, the $s$-wave scattering lengths for channel spins 1 and 2 were determined to be 17.34$^{+1.11}_{-1.33}$ and -3.18$^{+0.55}_{-0.50}$ fm, respectively. The uncertainty in the $s$-wave scattering lengths reported in this work is smaller by a factor of 5-8 compared to the previous measurement, which may reduce the overall uncertainty in $S_{17}$ at zero energy. The level structure of $^8$B is discussed based upon the results from this work. Evidence for the existence of 0$^+$ and 2$^+$ levels in $^8$B at 1.9 and 2.21 MeV, respectively, is observed.

Intermediate energy single-neutron removal from $^{31}$Mg has been employed to investigate the transition into the N=20 island of inversion. Levels up to 5~MeV excitation energy in $^{30}$Mg were populated and spin-parity assignments were inferred from the corresponding longitudinal momentum distributions and $\gamma$-ray decay scheme. Comparison with eikonal-model calculations also permitted spectroscopic factors to be deduced. Surprisingly, the 0$^{+}_{2}$ level in $^{30}$Mg was found to have a strength much weaker than expected in the conventional picture of a predominantly $2p - 2h$ intruder configuration having a large overlap with the deformed $^{31}$Mg ground state. In addition, negative parity levels were identified for the first time in $^{30}$Mg, one of which is located at low excitation energy. The results are discussed in the light of shell-model calculations employing two newly developed approaches with markedly different descriptions of the structure of $^{30}$Mg. It is concluded that the cross-shell effects in the region of the island of inversion at Z=12 are considerably more complex than previously thought and that $np - nh$ configurations play a major role in the structure of $^{30}$Mg., Comment: Physics Letters B, Volume 779, 10 April 2018, Pages 124-129

International audience; The N=20 island of inversion is an excellent playground for testing shell model calculations. The Mg chain is a region of shell evolution still far from being well understood. In this paper we present preliminary results of a single-neutron knockout experiment from 31Mg performed at GANIL to study the structure of 31Mg and of the core 30Mg. The level scheme and longitudinal momentum distributions were mesured and spectroscopic factors were deduced. Negative parity states arise at low energy and the spectroscopic factor for the isomeric in 30Mg was determined to be smaller than foreseen in the standard picture. The preliminary experimental results are compared to state-of the art shell model calculations revealing opposed interpretations.

Scattering of 8He from 4He has been performed through the coincident detection of the scattered particles using a silicon array within a helium-4 gas volume with a 8He beam. This permitted the reconstruction of the interaction probability as a function of position within the gas and hence the excitation function to be calculated together with the angular distribution of the products. These measurements also enabled the reconstruction of the two-neutron transfer to 6He + 6He. The measurements provide the first characterisation of the scattering of the α+4n, 8He, halo nucleus from 4He and the 2n-transfer to populate the symmetric final state. The results indicate the presence of a L=4 component at excitation energies of 14–15 MeV, consistent with a broad (∼1 MeV) Jπ=4+ resonance. These measurements would agree with generalized two-centre cluster model (GTCM) calculations indicating a cluster, or molecular, structure predicted at this energy. ispartof: Physics Letters B vol:775 pages:58-62 status: published

What environmental constraints will materials have to face in the future? Can current measurement tools like LCA (Life Cycle Analysis) support the choices of material and adapt to these constraints to pave the way to a sustainable world? Are there some alternative or complementary approaches to enhance the quality of information for decision makers? The aim of this article is to provide answers to these three questions. The society of tomorrow, in the second half of the 21st century, will be a society where the circular economy will play a more important role and thus will help reduce materials waste. This is a critical aspect of sustainability. To get there, the decisions have to be enlightened and fair, because the decisions (or non-decisions) made today shape the world that future generations will have to manage. Furthermore, Lord Kelvin used to say: “what you can’t measure, you can’t improve”. Therefore, these decisions have to be supported by measurement tools that will properly capture the stakes of reuse and recycling at the end of life of products. Today, LCA is the common tool used to address this matter. However, the present article has shown that LCA cannot incorporate the whole complexity of sustainability. LCA is good at considering micro-scale issues, comparing one solution with another, in a static approach. How can it give right directions to decision makers in order to support the vision of a circular economy? The application of different standards showed that it is not easy at all and that recycling product at their end of life are not rewarded equally and sometimes not promoted at all. Therefore rebound effects leading to contradictory decisions may occur. LCA alone is not enough to make enlightened decisions. It should be complemented by other methods. This was proposed in the last part. Based on the IPAT equation, this approach tries to capture different aspects that are not addressed properly by LCA, due to the fact that the functional unit is too restrictive, that the time dimension and prospective approach should be more integrated, and that it should enlarge the scale of the analysis to the macro-economy and the socio-economy. It should also recognize that the efforts have to be shared by different players including material industry and manufacturers, policy makers and society in general. As a general conclusion, we are convinced that tomorrow’s society will recognize the value of materials that are recyclable and reusable, like steel has been for many decades. But there is still a clear need to addressing, in research and development, the improvement of the metrics, combining social, environmental and economic assessment, so that the sustainability value of materials is properly measured. These are the objectives of the Sovamat Initiative and the SAM conferences.

Knowledge of the 3He(3He,2p)4He reaction is important for understanding stellar burning and solar neutrino production. Previous measurements have found a surprisingly large rise in the cross section at low energies that could be due to a low-energy resonance in the 3He + 3He (6Be) system or electron screening. In the 6Be nucleus, however, no excited states have been observed above the first 2+ state at Ex = 1.67 MeV up to 23 MeV, even though several are expected. The 2H(7Be,3H)6Be reaction has been studied for the first time to search for resonances in the 6Be nucleus that may affect our understanding of the 3He(3He,2p)4He reaction. A 100-MeV radioactive 7Be beam from the Holifield Radioactive Ion Beam Facility (HRIBF) was used to bombard CD2 targets, and tritons were detected by using the silicon detector array (SIDAR). A combination of reaction mechanisms appears to be necessary to explain the observed triton energy spectrum.

Summary This report defines four levels of care required for the management of adult patients with haematological malignancies and marrow failure (acute and chronic leukaemias, lymphomas, myelodysplastic and myeloproliferative disorders, myeloma and severe aplastic anaemia). The higher levels of care require increasing specialist expertise, staffing and resources. Staffing includes both the medical, nursing and scientific/laboratory professions and other support staff. Resources include ward provision, bed numbers, equipment, laboratory and radiotherapy facilities, pharmacy, support services and research. Blood transfusion services and their organisation are discussed separately. The guidelines indicate to providers and purchasers the issues to be considered in placing contracts for the care of these patients. A glossary of terms is provided for purchasers.

We report here on experiments with radioactive 21 Na and 7 Be beams performed by Colorado School of Mines students at the ISAC facility of TRIUMF and the Holifield Radioactive Ion Beam Facility (HRIBF) of ORNL. At TRIUMF, the DRAGON recoil separator and its segmented BGO array were used to investigate higher energy resonances in the reaction H( 21 Na, γ) 22 Mg. Using the HRIBF we performed an experiment with a 7 Be ion beam to measure scattering off Hydrogen and Carbon. Both elastic 7 Be + p scattering and for the first time resonant inelastic scattering 7 Be(p, p′) 7 Be ∗ were observed.

The development of high quality radioactive beams, such as those at the HRIBF at Oak Ridge National Laboratory, has made possible the measurement of transfer reactions in inverse kinematics on unstable nuclei. Measurement of (d,p) reactions on neutron-rich nuclei yield data on the evolution of nuclear structure away from stability, and are of astrophysical interest due to the proximity of suggested nuclear burning paths in the astrophysical r-process in supernovae. Experimentally, (d,p) reactions on heavy (Z = 50) fission fragments are complicated by the strongly inverse kinematics, and the relatively low beam intensities. Consequently, ejectile detection with high resolution in position and energy, a high dynamic range and a high solid angular coverage is required. The Oak Ridge Rutgers University Barrel Array (ORRUBA) is a new silicon detector array currently under construction, optimized for the measurement of (d,p) reactions in inverse kinematics. It consists of two rings of silicon detectors, providing a high solid angular coverage for angles symmetrically forward and backward of 90°. Resistive strip detectors are used to obtain high precision position and energy measurement of reaction ejectiles.

A technique for measuring mass differences has been developed at the Holifield Radioactive Ion Beam Facility (HRIBF) that requires no specialized equipment. Mass differences are measured as position differences between known and unknown-mass isobars, dispersed at the image of the energy-analyzing magnet following the 25 MV tandem post-accelerator, and identified by an energy-loss measurement. The technique has been demonstrated on neutron-rich 77–79Cu and 83–86Ge isotopes produced using the isotope separator online (ISOL) method with the 238U(p,fission) reaction, where a mass accuracy of 500 keV was achieved. These nuclides are well suited to the measurement technique, as they readily migrate out of the production target and to the ion source and comprise the most neutron-rich elements of the isobarically mixed beam. Because modest precision mass values can be obtained with only a few tens of counts of the nuclide of interest among orders of magnitude more of the isobaric neighbors closer to stability, the sensitivity of this technique makes it appropriate for initial mass measurements far from stability.

Initial measurements are presented of the (d,p) reactions on neutron-rich N = 50 isotones along the r-process path of nucleosynthesis with radioactive ion beams of 82Ge and 84Se. Prospects for measurements with unstable 130,132Sn beams are discussed.

Single-neutron transfer reactions have been measured on two N = 50 isotones at the Holifield Radioactive Ion Beam Facility (HRIBF). The single-particle-like states of 83Ge and 85Se have been populated using radioactive ion beams of 82Ge and 84Se and the (d, p) reaction in inverse kinematics. The properties of the lowest-lying states —including excitation energies, orbital angular momenta, and spectroscopic factors— have been determined for these N = 51 nuclei.

The degree to which the (p, γ) and (p,α) reactions destroy 18F at temperatures ∼ 1 − 4 × 10 8 K is important for understanding the synthesis of nuclei in nova explosions and for using the long-lived radionuclide 18F, a target of gamma ray astronomy, as a diagnostic of nova mechanisms. The reactions are dominated by low-lying proton resonances near the 18F+p threshold ( E x = 6.411 MeV in 19Ne). To gain further information about these resonances, we have used the d(18F,p)19F neutron transfer reaction to selectively populate corresponding mirror states in 19F. The results would suggest 18F(p,γ)19Ne and 18F(p,α)15O reaction rates that are 2-3 times lower than reported previously.

The fusion of protons with radioactive nuclei is important in stellar explosions such as novae and X-ray bursts and for the production of neutrinos in the sun. The Daresbury Recoil Separator and a windowless gas target system have been installed at ORNL's Holifield Radioactive Ion Beam Facility (HRIBF) for measurements of proton capture reactions in inverse kinematics with radioactive ion beams. The performance of the system has been characterized with a number of experiments using stable ion beams. We report on results from these commissioning measurements and plans for measurements of the 1 H( 17 F, 18 Ne) and 1 H( 7 Be, 8 B) reactions.

The study of neutron single-particle strengths in neutron-rich nuclei is of interest for nuclear structure and nuclear astrophysics. The distribution of single-particle strengths constrains the effective Hamiltonian and pairing interactions and determines neutron interaction rates that are crucial for understanding the synthesis of heavy nuclei in supernovae via the rapid neutron capture process. Particularly important are the neutron single-particle levels in nuclei near closed neutron shells. Radioactive ion beams from the Holifield Radioactive Ion Beam Facility have been used to study (d,p) reactions in inverse kinematics in order to probe neutron single-particle states in exotic nuclei. The results of a measurement with a 82 Ge beam will be presented.

In a sustainable development context, the storm water reuse in industry seems a promising and original alternative, but few experiences exist. A project, sponsored by the European Community and the Artois-Picardie Water Agency, has been carried out by the Renault MCA factory in Maubeuge, demonstrating that it can be profitable, in certain conditions, to reuse storm water in industrial processes. This article summarises this experience, and presents a decision making tool (SIRRUS) that has been developed in this framework by Anjou Recherche (Vivendi Water) to evaluate, on the basis of simple criteria, if this experience is or is not reproducible on a given site, and how much time is necessary to pay the investment back. Its application and different results are also discussed.

The low-lying level structure of the unbound neutron-rich nucleus $^{13}$Be has been investigated via breakup on a carbon target of secondary beams of $^{14,15}$B at 35 MeV/nucleon. The coincident detection of the beam velocity $^{12}$Be fragments and neutrons permitted the invariant mass of the $^{12}$Be+$n$ and $^{12}$Be+$n$+$n$ systems to be reconstructed. In the case of the breakup of $^{15}$B, a very narrow structure at threshold was observed in the $^{12}$Be+$n$ channel. Contrary to earlier stable beam fragmentation studies which identified this as a strongly interacting $s$-wave virtual state in $^{13}$Be, analysis here of the $^{12}$Be+$n$+$n$ events demonstrated that this was an artifact resulting from the sequential-decay of the $^{14}$Be(2$^+$) state. Single-proton removal from $^{14}$B was found to populate a broad low-lying structure some 0.70 MeV above the neutron-decay threshold in addition to a less prominent feature at around 2.4 MeV. Based on the selectivity of the reaction and a comparison with (0-3)$\hbar\omega$ shell-model calculations, the low-lying structure is concluded to most probably arise from closely spaced J$^\pi$=1/2$^+$ and 5/2$^+$ resonances (E$_r$=0.40$\pm$0.03 and 0.85$^{+0.15}_{-0.11}$ MeV), whilst the broad higher-lying feature is a second 5/2$^+$ level (E$_r$=2.35$\pm$0.14 MeV). Taken in conjunction with earlier studies, it would appear that the lowest 1/2$^+$ and 1/2$^-$ levels lie relatively close together below 1 MeV., Comment: 14 pages, 13 figures, 2 tables. Accepted for publication in Physical Review C

Vertical-cavity surface-emitting lasers (VCSELs) are complex multi-layer structures whose operating characteristics are highly sensitive to variations in layer thickness and composition. We have made non-destructive measurements of the thickness of GaAs/AlAs layers in three wafer-sized VCSEL substructures, consisting of partial distributed Bragg reflectors, grown by metal-organic vapour-phase epitaxy. A range of techniques were investigated and compared, including reflectance, photo-modulated reflectance, spectroscopic ellipsometry and high-resolution x-ray diffraction. The results obtained from each technique for the layer thicknesses are equal to each other to within ±~1%. The precision of the optical techniques is as good as, and sometimes better than, direct measurements made using destructive cross-sectional transmission electron microscopy.

Two InGaAs/GaAs/AlAs vertical-cavity surface emitting laser (VCSEL) structures have been studied by conventional reflectance (R) and photomodulated reflectance (PR) spectroscopies at \ensuremath{\sim}300 K and \ensuremath{\sim}80 K. Growth variations across the samples (2%) give rise to smooth changes in the cavity mode energy so that it can be tuned through the position of resonance with the quantum well (QW) ground-state exciton, by varying the position of measurement. The R spectra show the cavity mode but at best only a weak excitonic feature. In contrast, the PR shows two prominent and distinct signals, and there is a strong enhancement (up to 40 times) at resonance. A theory has been developed for the PR modulation of the coupled cavity and exciton modes, based on energy dependent Seraphin coefficients. This was used to fit all the PR spectra simultaneously in each complete set of position dependent measurements, using seven parameters, only one of which, the cavity mode energy, varied significantly. The resulting cavity mode and excitonic energies do not clearly show an anticrossing behavior near resonance, implying only a weak exciton-cavity coupling. The ability of PR to detect, in a nondestructive manner, both the cavity and exciton modes, and the extent to which they are in resonance, suggests it could be extremely useful in the characterization of VCSEL structures near their operating temperature.

Neutron-capture reactions on neutron-rich nuclei are important to understand r-process nucleosynthesis, as well as applied needs such as stewardship science and nuclear energy. Because of the short half-lives of these species, it is not possible to measure these reactions directly with neutron beams on unstable targets. The (d,pγ) reaction with radioactive ion beams has been proposed as a surrogate reaction for (n,γ). Experiments to develop (d,pγ) techniques with radioactive ion beams and to demonstrate the efficacy of the (d,pγ) reaction as a surrogate for (n,γ) are discussed.

The 12 C( 12 C, 2n) 22 Mg reaction was measured with the CLARION array and the RMS separator at the Holifield Facility of Oak Ridge National Laboratory. This experiment was performed to gather more information on the excited states in 22 Mg, which might be of relevance to recent radioactive ion beam measurements of the astrophysically important 21 Na(p, γ) 22 Mg reaction. The results are compared to direct measurements, transfer experiments and a competing experiment performed with Gammasphere.

An onshore shallow marine sandbody has been investigated in several extensive quarry outcrops in the Norfolk area of eastern England in terms of its sedimentology (sedimentary structures, geometry and architecture), sequence stratigraphy and reservoir-scale heterogeneity. In addition to conventional sedimentological logging techniques, vertical profiles were analysed using a steady-state electronic probe permeameter to investigate permeability heterogeneity. Permeability analysis was also complemented by spectral gamma ray profiles, which were used to characterize facies associations in terms of their total radioactivity and relative proportions of potassium, uranium and thorium. It was found that lithofacies type and bounding surface have the dominant control on permeability heterogeneity and thus flow unit compartmentalization. This study aims to complement pre-existing outcrop analogue datasets which attempt to model fluid flow more accurately in analogous subsurface reservoirs. It also serves to highlight the difficulty in accurately identifying and modelling subsurface shallow marine/estuarine tidal channel depositional systems for well/drainage and or production strategies.

An understanding of the binding specificity of leukocyte integrins is important to determine the range of ligands that interact with these receptors during inflammatory processes. In this study we show that the α4β1 integrin can interact with casein and denatured albumin and promote leukocyte adhesion through these interactions. This was demonstrated with the use of blocking antibodies directed to α4β1 and peptide adhesion competitors containing the α4β1 binding tripeptide, Leu-Asp-Val (LDV). Consistent with this data, the adhesion is completely divalent cation-dependent and is stimulated by known activators of leukocyte integrin function, namely phorbol ester and the β1 integrin activating antibody, 8A2. It is interesting to note that neither bovine α-casein or human albumin contain an LDV site (present in the CS-1 site of alternatively spliced fibronectin) or an IDS site (present in VCAM-1) yet they promote adhesion through this integrin. Furthermore, α4β1 directly binds to Sepharose columns containing casein, casein fragments, or denatured albumin but does not bind columns containing native albumin. These data suggest that the binding specificity for the α4β1 integrin is considerably broader than previously realized. This work has implications for how subsets of leukocytes may interact with damaged proteins during tissue injury and inflammation.

A measurement of the (d, p) reaction in inverse kinematics at energies near the Coulomb barrier using a stable beam of 124Sn has been performed at ORNL’s Holifield Radioactive Ion Beam Facility (HRIBF). The sensitivity of proton angular distributions to the transferred angular momentum has been demonstrated. Spectroscopic factors have been extracted for three states and are in agreement with previous measurements made in normal kinematics.

Attendance at face-to-face sessions and completion of online components of the National Prescribing Curriculum was made compulsory for final year medical students at the University of Adelaide in 2010.To determine the impact of a compulsory prescribing curriculum for final year medical students on their prescribing competencies at the start of clinical practice. Graduates' attitudes to their medical school training in prescribing were also surveyed.Two cohorts of medical graduates from the University of Adelaide who commenced medical practice in 2010 and 2011 were required to complete a prescribing task using the National Inpatient Medication Chart (NIMC) at orientation and after 6 months of clinical practice. The main outcome measure was a performance in a scenario-based prescribing test, as determined by test scores and overall safety of prescriptions at orientation and 6 months of clinical practice.There was a small difference in the average total score for the prescribing task between the 2010 and 2011 cohorts at orientation (P = 0.0007). The 2011 cohort had a higher number of safer charts at commencement of practice. We found no difference between the 2010 and 2011 cohorts in attitudes towards their undergraduate pharmacology education, and new graduates feel poorly prepared.Medical graduates who are required to complete a practically oriented prescribing curriculum in final year perform slightly better on a prescribing assessment at commencement of practice. More work on preparing graduates for this complex task before graduation is needed.

The 17 F( p ,γ) 18 Ne direct capture cross section is important for understanding nucleosynthesis in novae. We have measured cross sections for the proton-transfer reaction 14 N( 17 F, 18 Ne) 13 C in order to determine asymptotic normalization coefficients for the 17 F+ p system and hence the 17 F( p ,γ) 18 Ne direct capture cross section. The technique and preliminary results are presented.

In the present measurements a ${}^{12}$C target was bombarded by a ${}^{4}$He beam with energies from 14 to 21 MeV and the excitation function measurements for the reactions of the ${}^{12}$C$({}^{4}$He, ${}^{8}$Be)${}^{8}$Be, ${}^{12}$C(${}^{4}$He, ${}^{12}$C$[7.65,{0}^{+}]$)${}^{4}$He, and ${}^{12}$C(${}^{4}$He, ${}^{12}$C$[9.64,{3}^{\ensuremath{-}}]$)${}^{4}$He were obtained using an array of 6 double-sided silicon strip detectors. The excitation functions are used to gain an insight into possible $\ensuremath{\alpha}$-cluster structures in ${}^{16}$O.

We present the first predictions for the widths of resonance states in a so-far unobserved exotic isotope beyond the proton dripline, 21Al. For this purpose we employ mirror symmetry between the widths of low-lying resonance states and the asymptotic normalization coefficients (ANC) of their mirror analogs. The latter are extracted from a recently measured peripheral reaction 20O(d,p)21O while the positions of resonances are estimated within a microscopic cluster model and a two-body potential model. We have found that 21Al should have two low-lying states decaying into the 20Mg+p channel and three states at higher energy, built on the 2+ core excited state and decaying into the 20Mg(2+)+p channel. The widths of all these states are much smaller than their energies, which makes experimental spectroscopic studies of this isotope beyond the proton dripline possible. © 2012 American Physical Society.

Background: To understand explosive hydrogen burning in stars and to explore various explosive scenarios such as type I x-ray bursts (XRBs), reliable reaction rates are needed. The cross sections for radiative proton capture on near-dripline nuclei are necessary for the determination of the reaction rates, but cannot be measured directly.Purpose: To determine the reaction rate for the radiative proton capture reaction ${}^{23}\mathrm{Al}{(p,\ensuremath{\gamma})}^{24}\mathrm{Si}$ using indirect methods and, as a consequence, evaluate if sequential $2p$ capture on ${}^{22}$Mg seed nuclei is significant at high temperatures.Method: Nonresonant radiative proton capture on ${}^{23}$Al is investigated using the one-proton breakup of ${}^{24}$Si at 61 MeV/nucleon and the asymptotic normalization coefficient (ANC) for ${}^{24}{\mathrm{Si}}_{\mathrm{gs}}\ensuremath{\rightarrow}{}^{23}\mathrm{Al}+p$ is deduced.Results: From the ANC, the nonresonant component of the astrophysical $S$-factor for the ${}^{23}\mathrm{Al}{(p,\ensuremath{\gamma})}^{24}\mathrm{Si}$ reaction is determined and, using other new experimental data the resonant component is re-evaluated.Conclusions: The ${}^{23}\mathrm{Al}{(p,\ensuremath{\gamma})}^{24}\mathrm{Si}$ reaction is of interest for type I XRB nucleosynthesis and its reaction rate can affect both the ${}^{22}$Na abundance and the total energy output. New determinations of the rates for the ${}^{22}\mathrm{Mg}{(p,\ensuremath{\gamma})}^{23}\mathrm{Al}{(p,\ensuremath{\gamma})}^{24}\mathrm{Si}$ reaction chain are provided here and we point to the need that they be included in XRB scenarios.

A good understanding of the level structure of ${}^{19}\mathrm{Ne}$ around the proton threshold is critical to estimating the destruction of long-lived ${}^{18}\mathrm{F}$ in novae. Here we report the properties of levels in ${}^{19}\mathrm{Ne}$ in the excitation energy range of 6.9 $\ensuremath{\leqslant}$ ${E}_{x}$ $\ensuremath{\leqslant}$ 8.4 MeV studied via the proton-transfer ${}^{18}\mathrm{F}(d,n){\mathrm{Ne}}^{*}$ reaction at the Holifield Radioactive Ion Beam Facility. The populated ${}^{19}\mathrm{Ne}$ levels decay by breakup into $p+{}^{18}\mathrm{F}$ and $\ensuremath{\alpha}+{}^{15}\mathrm{O}$ particles. The results presented in this manuscript are those of levels that are simultaneously observed from the breakup into both channels. An $s$-wave state is observed at 1468 keV above the proton threshold, which is a potential candidate for a predicted broad ${J}^{\ensuremath{\pi}}$ $=$ 1/2${}^{+}$ state. The proton and $\ensuremath{\alpha}$ partial widths are deduced to be ${\ensuremath{\Gamma}}_{p}$ $=$ 228 $\ifmmode\pm\else\textpm\fi{}$ 50 keV and ${\ensuremath{\Gamma}}_{\ensuremath{\alpha}}$ $=$ 130 $\ifmmode\pm\else\textpm\fi{}$ 30 keV for this state.

The quenching of the N=20 shell gap in neutron-rich nuclei is investigated by studying the single-particle structure of 27Ne via neutron transfer using a 26Ne beam. Two low-lying negative-parity intruder states have been observed, the lowest of which is identified as Jπ=3/2−, confirming earlier speculations. A level identified as 7/2− is observed higher in energy than the 3/2−, contrary to the ordering at β-stability and at an energy significantly different from the predictions of previous shell-model calculations. The measured energies and deduced spectroscopic factors are well reproduced in full (0,1)-ℏω 0s-0p-0d-1s-0f-1p calculations in which there is a significant ad hoc reduction (∼0.7 MeV) in the N=20 shell gap.

Thirty-six of 36 strains of Enterobacter cloacae and E. aerogenes with inducible beta-lactamase developed resistance when cefoxitin (inducer) was added to cefuroxime disks. Constitutive beta-lactamase producers (n = 23) were all resistant to cefuroxime. Cefuroxime resistance correlated with the amount of induced or constitutive beta-lactamase. Cefuroxime was a better indicator of induced resistance than cefamandole, cefazolin, cephalothin, ceftriaxone, cefotaxime, ticarcillin with or without clavulanic acid, or cefotetan. Induction by addition of cefoxitin to disks occasionally reduced zone sizes but not enough to change interpretations for ceftazidime, ceftizoxime, aztreonam, cefoperazone with or without sulbactam, and piperacillin with or without tazobactam. Most enterobacters were resistant to cefmetazole. The cefoxitin inducer-cefuroxime indicator method can be used in routine clinical laboratories to detect latent resistance due to chromosomally mediated inducible beta-lactamase in enterobacters.

Simultaneous measurement of the proton-transfer {sup 18}F(d, n){sup 19}Ne and neutron-transfer {sup 18}F(d, p){sup 19}F reactions were performed with a {sup 18}F radioactive beam at the Holifield Radioactive Ion Beam Facility at Oak Ridge National Laboratory. The experiments clarify the nuclear structure of {sup 19}Ne near the proton threshold, which is relevant for understanding the rates of proton-induced reactions on {sup 18}F in novae. Analogs for several states in the mirror nucleus {sup 19}F have not yet been identified in {sup 19}Ne, indicating that the level structure of {sup 19}Ne in this region is incomplete. We observed 15 levels in {sup 19}Ne from the {sup 18}F(d, n){sup 19}Ne measurement and 18 levels in {sup 19}F from the {sup 18}F(d, p){sup 19}F measurement. Angular distributions were extracted for all strongly populated states and compared to distorted-wave Born approximation calculations. The angular distributions for all the known states in the two nuclei determined in this work are consistent with their previously assigned spins and parities. The spectroscopic factors determined for these levels in the two nuclei are reported.

Urethral calculi are extremely rarely reported in Caucasian females and are usually associated with an anatomical abnormality such as a diverticulum or a stricture. Ureteric calculi can move to become lodged in the urethra, although this is rare in women because of their short urethral length. We present a case of a 55-year-old woman presenting with urinary retention secondary to an obstructing upper tract calculus that had moved into the urethra. Four years previously, the patient had been diagnosed with chronic pelvic pain following a primary posterior vaginal wall repair. Following treatment of the obstructing calculus, her symptoms of pelvic pain completely resolved. We report a very unusual case that highlights the importance of investigating chronic pelvic pain. This patient’s symptom of vaginal pain, though highly localized, was caused by pathology elsewhere in the pelvis. Alternative diagnoses should be sought for such patients and investigation performed to detect any nonvisible hematuria.

This is the publisher's version, also available electronically from http://journals.aps.org/prc/abstract/10.1103/PhysRevC.84.011301.

The ${}^{18}\mathrm{F}(p,\ensuremath{\alpha}){}^{15}\mathrm{O}$ reaction is the predominant destruction mechanism in novae of the radionuclide $^{18}\mathrm{F}$, a target of $\ensuremath{\gamma}$-ray observatories. Thus, its rate is important for understanding $^{18}\mathrm{F}$ production in novae. We have studied resonances in the ${}^{18}\mathrm{F}+p$ system by making a measurement of a proton-transfer reaction ${}^{18}\mathrm{F}(d,n)$. We have observed 15 $^{19}\mathrm{Ne}$ levels, 5 of which are below the proton threshold, including a subthreshold state, which has significant ${l}_{p}=0$ strength. Our data provide a direct determination of the spectroscopic strength of these states and new constraints on their spins and parities, thereby resolving a controversy, which involves the 8- and 38-keV resonances. The ${}^{18}\mathrm{F}(p,\ensuremath{\alpha}){}^{15}\mathrm{O}$ reaction rate is reevaluated, which takes the subthreshold resonance and other new information determined in this experiment into account.

The (d,p) neutron transfer and (d,d) elastic scattering reactions were measured in inverse kinematics using a radioactive ion beam of 132Sn at 630 MeV. The elastic scattering data were taken in a region where Rutherford scattering dominated the reaction, and nuclear effects account for less than 8% of the cross section. The magnitude of the nuclear effects was found to be independent of the optical potential used, allowing the transfer data to be normalized in a reliable manner. The neutron-transfer reaction populated a previously unmeasured state at 1363 keV, which is most likely the single-particle 3p1/2 state expected above the N=82 shell closure. The data were analyzed using finite range adiabatic wave calculations and the results compared with the previous analysis using the distorted wave Born approximation. Angular distributions for the ground and first excited states are consistent with the previous tentative spin and parity assignments. Spectroscopic factors extracted from the differential cross sections are similar to those found for the one neutron states beyond the benchmark doubly-magic nucleus 208Pb., Comment: 22 pages, 7 figures

The structure and 2α+2p breakup of 10C, the only known Brunnian nucleus, has been studied at 33.3 MeV/nucleon. The breakup kinematics were used to reconstruct the 10C → 9B +p, 9B → 8Be +p, 8Be →α+α and 10C → 6Be +α, 6Be → 5Li +p, 5Li →α+p decay paths. Proton emission was seen to be favored. The decay of excited states at Ex=4.20, 5.31, and 6.74 MeV was observed. The previously unobserved state at 4.20 MeV may correspond to a Jπ=0+α+2p+α cluster structure.

Expérience GANIL; International audience; We discuss the use of one‐nucleon removal reactions of loosely bound nuclei at intermediate energies as an indirect method in nuclear astrophysics. The breakup reactions are proved to be good spectroscopic tools and can be used to study a large number of loosely bound proton‐ or neutron‐rich nuclei over a wide range of beam energies. As peripheral processes, they can be used to extract asymptotic normalization coefficients (ANCs) from which non‐resonant capture reaction rates of astrophysical interest can be calculated parameter free. In this talk, we present results of a proton‐breakup experiment carried out at GANIL (France) with a cocktail beam centered around 23Al at 50 MeV/nucleon. Momentum distributions of the breakup fragments, inclusive and in coincidence with gamma rays detected by EXOGAM Germanium clover array, were measured in the focal plan of SPEG energy‐loss spectrometer. We present in particular the investigations of reaction rates for 22Mg(p,γ)23Al and 23Al(p,γ)24Si important for novae and X‐ray bursts, respectively.

Atomic nuclei have a shell structure where nuclei with 'magic numbers' of neutrons and protons are analogous to the noble gases in atomic physics. Only ten nuclei with the standard magic numbers of both neutrons and protons have so far been observed. The nuclear shell model is founded on the precept that neutrons and protons can move as independent particles in orbitals with discrete quantum numbers, subject to a mean field generated by all the other nucleons. Knowledge of the properties of single-particle states outside nuclear shell closures in exotic nuclei is important for a fundamental understanding of nuclear structure and nucleosynthesis (for example the r-process, which is responsible for the production of about half of the heavy elements). However, as a result of their short lifetimes, there is a paucity of knowledge about the nature of single-particle states outside exotic doubly magic nuclei. Here we measure the single-particle character of the levels in 133Sn that lie outside the double shell closure present at the short-lived nucleus 132Sn. We use an inverse kinematics technique that involves the transfer of a single nucleon to the nucleus. The purity of the measured single-particle states clearly illustrates the magic nature of 132Sn., 19 pages, 5 figures and 4 tables