204 results on '"J. Rutka"'
Search Results
2. GP.4 The epilepsy surgery experience in children with infantile spasms at a tertiary care centre in Canada
- Author
-
J Gettings, S Shafi, J Boyd, O Snead, J Rutka, J Drake, B McCoy, P Jain, R Whitney, and C Go
- Subjects
Neurology ,Neurology (clinical) ,General Medicine - Abstract
Background: Infantile spasms (IS) is an epileptic encephalopathy, characterized by spasms, hypsarrhythmia, and developmental regression. This is a retrospective case series of children with IS who underwent epilepsy surgery at The Hospital for Sick Children (HSC) in Toronto, Canada. Methods: The records of 223 patients seen in the IS clinic were reviewed. Results: Nineteen patients met inclusion criteria. The etiology of IS was encephalomalacia in six patients (32%), malformations of cortical development in 11 patients (58%), atypical hypoglycaemic injury in one patient (5%), and partial hemimegalencephaly in one patient (5%). Nine patients (47%) underwent hemispherectomy and 10 patients (53%) underwent lobectomy/lesionectomy. Three patients (16%) underwent a second epilepsy surgery. Fifteen patients (79%) were considered ILAE Seizure Outcome Class 1 (completely seizure free; no auras). The percentage of patients who were ILAE Class 1 at most recent follow-up decreased with increasing duration of epilepsy prior to surgery. Developmental outcome was improved in 14/19 (74%) and stable in 5/19 (26%) patients. Conclusions: Our study found excellent seizure freedom rates and improved developmental outcomes following epilepsy surgery in patients with a history of IS with a structural lesion detected on MRI brain.
- Published
- 2022
3. P.098 The Epilepsy Surgery Experience in Children with Infantile Spasms at the Hospital for Sick Children
- Author
-
J Gettings, S Shafi, J Boyd, O Snead, J Rutka, J Drake, B McCoy, R Whitney, and C Go
- Subjects
Neurology ,Neurology (clinical) ,General Medicine - Abstract
Background: Infantile spasms (IS) is an epileptic encephalopathy, characterized by epileptic spasms, hypsarrhythmia, and developmental regression. This is a retrospective case series detailing the experience in children with IS who have undergone epilepsy surgery at The Hospital for Sick Children (HSC). Methods: Records of 223 patients from HSC were reviewed. Patients were included if they had a current or previous history of IS with a lesion detected on MRI/PET scan who underwent epilepsy surgery. Results: Nineteen patients were included. The etiology of IS was encephalomalacia in six patients (32%), malformations of cortical development in 11 patients (58%), atypical hypoglycaemic injury in one patient (0.5%), and partial hemimegalencephaly in one patient (0.5%). The median age at the onset of IS was five months. The median age at surgery was 18 months. Nine patients (47%) underwent hemispherectomy and 10 patients (53%) underwent lobectomy/lesionectomy. Fifteen patients (79%) were considered ILAE Seizure Outcome Class 1. Developmental outcome was improved in 14/19 (74%) and stable in 5/19 (26%) patients. Conclusions: Even with a generalized EEG pattern such as hypsarrhythmia, patients should be considered for focal resective surgery. Early surgical intervention shortens the duration of active epilepsy thus limiting the potentially irreversible effects of on-going seizures.
- Published
- 2021
4. MEDULLOBLASTOMA
- Author
-
G. Vaidyanathan, S. Gururangan, D. Bigner, M. Zalutsky, M. Morfouace, A. Shelat, J. Megan, B. B. Freeman, S. Robinson, S. Throm, J. M. Olson, X.-N. Li, K. R. Guy, G. Robinson, C. Stewart, A. Gajjar, M. Roussel, N. Sirachainan, S. Pakakasama, U. Anurathapan, A. Hansasuta, M. Dhanachai, C. Khongkhatithum, S. Hongeng, A. Feroze, K.-S. Lee, S. Gholamin, Z. Wu, B. Lu, S. Mitra, S. Cheshier, P. Northcott, C. Lee, T. Zichner, P. Lichter, J. Korbel, R. Wechsler-Reya, S. Pfister, I. P. T. Project, K. K.-W. Li, T. Xia, F. M. T. Ma, R. Zhang, L. Zhou, K.-M. Lau, H.-K. Ng, L. Lafay-Cousin, S. Chi, J. Madden, A. Smith, E. Wells, E. Owens, D. Strother, N. Foreman, R. Packer, E. Bouffet, T. Wataya, J. Peacock, M. D. Taylor, D. Ivanov, M. Garnett, T. Parker, C. Alexander, L. Meijer, R. Grundy, P. Gellert, M. Ashford, D. Walker, J. Brent, F. Z. Cader, D. Ford, A. Kay, R. Walsh, G. Solanki, A. Peet, M. English, T. Shalaby, G. Fiaschetti, S. Baulande, N. Gerber, M. Baumgartner, M. Grotzer, T. Hayase, Y. Kawahara, M. Yagi, T. Minami, N. Kanai, T. Yamaguchi, A. Gomi, A. Morimoto, R. Hill, S. Kuijper, J. Lindsey, E. Schwalbe, K. Barker, J. Boult, D. Williamson, Z. Ahmad, A. Hallsworth, S. Ryan, E. Poon, R. Ruddle, F. Raynaud, L. Howell, C. Kwok, A. Joshi, S. L. Nicholson, S. Crosier, S. Wharton, K. Robson, A. Michalski, D. Hargrave, T. Jacques, B. Pizer, S. Bailey, F. Swartling, K. Petrie, W. Weiss, L. Chesler, S. Clifford, L. Kitanovski, T. Prelog, B. F. Kotnik, M. Debeljak, M. A. Grotzer, A. Gevorgian, E. Morozova, I. Kazantsev, T. Iukhta, S. Safonova, E. Kumirova, Y. Punanov, B. Afanasyev, O. Zheludkova, W. Grajkowska, M. Pronicki, B. Cukrowska, B. Dembowska-Baginska, M. Lastowska, A. Murase, S. Nobusawa, Y. Gemma, F. Yamazaki, A. Masuzawa, T. Uno, T. Osumi, Y. Shioda, C. Kiyotani, T. Mori, K. Matsumoto, H. Ogiwara, N. Morota, J. Hirato, A. Nakazawa, K. Terashima, T. Fay-McClymont, K. Walsh, D. Mabbott, D. Sturm, P. A. Northcott, D. T. W. Jones, A. Korshunov, S. M. Pfister, M. Kool, C. Hooper, S. Hawes, U. Kees, N. Gottardo, P. Dallas, A. Siegfried, A. I. Bertozzi, A. Sevely, N. Loukh, C. Munzer, C. Miquel, F. Bourdeaut, T. Pietsch, C. Dufour, M. B. Delisle, D. Kawauchi, J. Rehg, D. Finkelstein, F. Zindy, T. Phoenix, R. Gilbertson, J. Trubicka, M. Borucka-Mankiewicz, E. Ciara, K. Chrzanowska, M. Perek-Polnik, D. Abramczuk-Piekutowska, D. Jurkiewicz, S. Luczak, P. Kowalski, M. Krajewska-Walasek, C. Sheila, S. Lee, C. Foster, B. Manoranjan, M. Pambit, R. Berns, A. Fotovati, C. Venugopal, K. O'Halloran, A. Narendran, C. Hawkins, V. Ramaswamy, M. Taylor, A. Singhal, J. Hukin, R. Rassekh, S. Yip, S. Singh, C. Duhman, S. Dunn, T. Chen, S. Rush, H. Fuji, Y. Ishida, T. Onoe, T. Kanda, Y. Kase, H. Yamashita, S. Murayama, Y. Nakasu, T. Kurimoto, A. Kondo, S. Sakaguchi, J. Fujimura, M. Saito, T. Arakawa, H. Arai, T. Shimizu, E. Jurkiewicz, P. Daszkiewicz, M. Drogosiewicz, V. Hovestadt, I. Buchhalter, N. N. Jager, A. Stuetz, P. Johann, C. Schmidt, M. Ryzhova, P. Landgraf, M. Hasselblatt, U. Schuller, M.-L. Yaspo, A. von Deimling, R. Eils, A. Modi, M. Patel, M. Berk, L.-x. Wang, G. Plautz, H. Camara-Costa, A. Resch, C. Lalande, V. Kieffer, G. Poggi, C. Kennedy, K. Bull, G. Calaminus, J. Grill, F. Doz, S. Rutkowski, M. Massimino, R.-D. Kortmann, B. Lannering, G. Dellatolas, M. Chevignard, D. Solecki, P. McKinnon, J. Olson, J. Hayden, D. Ellison, M. Buss, M. Remke, J. Lee, T. Caspary, R. Castellino, M. Sabel, G. Gustafsson, G. Fleischhack, M. Benesch, A. Navajas, R. Reddingius, M.-B. Delisle, D. Lafon, N. Sevenet, G. Pierron, O. Delattre, J. Ecker, I. Oehme, R. Mazitschek, M. Lodrini, H. E. Deubzer, A. E. Kulozik, O. Witt, T. Milde, D. Patmore, N. Boulos, K. Wright, S. Boop, T. Janicki, S. Burzynski, G. Burzynski, A. Marszalek, J. Triscott, M. Green, S. R. Rassekh, B. Toyota, C. Dunham, S. E. Dunn, K.-W. Liu, Y. Pei, L. Genovesi, P. Ji, M. Davis, C. G. Ng, Y.-J. Cho, N. Jenkins, N. Copeland, B. Wainwright, Y. Tang, S. Schubert, B. Nguyen, S. Masoud, A. Lee, M. Willardson, P. Bandopadhayay, G. Bergthold, S. Atwood, R. Whitson, J. Qi, R. Beroukhim, J. Tang, A. Oro, B. Link, J. Bradner, S. G. Vallero, D. Bertin, M. E. Basso, C. Milanaccio, P. Peretta, A. Cama, A. Mussano, S. Barra, G. Morana, I. Morra, P. Nozza, F. Fagioli, M. L. Garre, A. Darabi, E. Sanden, E. Visse, N. Stahl, P. Siesjo, D. Vaka, F. Vasquez, B. Weir, G. Cowley, C. Keller, W. Hahn, I. C. Gibbs, S. Partap, K. Yeom, M. Martinez, H. Vogel, S. S. Donaldson, P. Fisher, S. Perreault, L. Guerrini-Rousseau, S. Pujet, V. Kieffer-Renaux, M. A. Raquin, P. Varlet, A. Longaud, C. Sainte-Rose, D. Valteau-Couanet, J. Staal, L. S. Lau, H. Zhang, W. J. Ingram, Y. J. Cho, Y. Hathout, K. Brown, B. R. Rood, M. Handler, T. Hankinson, B. K. Kleinschmidt-Demasters, S. Hutter, D. T. Jones, N. Kagawa, R. Hirayama, N. Kijima, Y. Chiba, M. Kinoshita, K. Takano, D. Eino, S. Fukuya, F. Yamamoto, K. Nakanishi, N. Hashimoto, Y. Hashii, J. Hara, T. Yoshimine, J. Wang, C. Guo, Q. Yang, Z. Chen, I. Filipek, E. Swieszkowska, M. Tarasinska, D. Perek, R. Kebudi, B. Koc, O. Gorgun, F. Y. Agaoglu, J. Wolff, E. Darendeliler, K. Kerl, J. Gronych, J. McGlade, R. Endersby, H. Hii, T. Johns, J. Sastry, D. Murphy, M. Ronghe, C. Cunningham, F. Cowie, R. Jones, A. Calisto, M. Sangra, C. Mathieson, J. Brown, K. Phuakpet, V. Larouche, U. Bartels, T. Ishida, D. Hasegawa, K. Miyata, S. Ochi, A. Saito, A. Kozaki, T. Yanai, K. Kawasaki, K. Yamamoto, A. Kawamura, T. Nagashima, Y. Akasaka, T. Soejima, M. Yoshida, Y. Kosaka, A. von Bueren, T. Goschzik, R. Kortmann, K. von Hoff, C. Friedrich, A. z. Muehlen, M. Warmuth-Metz, N. Soerensen, F. Deinlein, I. Zwiener, A. Faldum, J. Kuehl, K. KRAMER, N. P. -Taskar, P. Zanzonico, J. L. Humm, S. L. Wolden, N.-K. V. Cheung, S. Venkataraman, I. Alimova, P. Harris, D. Birks, I. Balakrishnan, A. Griesinger, N. K. Foreman, R. Vibhakar, A. Margol, N. Robison, J. Gnanachandran, L. Hung, R. Kennedy, M. Vali, G. Dhall, J. Finlay, A. Erdrich-Epstein, M. Krieger, R. Drissi, M. Fouladi, F. Gilles, A. Judkins, R. Sposto, S. Asgharzadeh, A. Peyrl, M. Chocholous, S. Holm, P. Grillner, K. Blomgren, A. Azizi, T. Czech, B. Gustafsson, K. Dieckmann, U. Leiss, I. Slavc, S. Babelyan, I. Dolgopolov, R. Pimenov, G. Mentkevich, S. Gorelishev, M. Laskov, A. O. von Bueren, J. Nowak, R. D. Kortmann, M. Mynarek, K. Muller, N. U. Gerber, H. Ottensmeier, R. Kwiecien, M. Yankelevich, V. Boyarshinov, I. Glekov, S. Ozerov, S. Gorelyshev, A. Popa, N. Subbotina, A. M. Martin, C. Nirschl, M. Polanczyk, R. Bell, D. Martinez, L. M. Sullivan, M. Santi, P. C. Burger, J. M. Taube, C. G. Drake, D. M. Pardoll, M. Lim, L. Li, W.-G. Wang, J.-X. Pu, H.-D. Sun, R. Ruggieri, M. H. Symons, M. I. Vanan, S. Bolin, S. Schumacher, R. Zeid, F. Yu, N. Vue, W. Gibson, B. Paolella, F. J. Swartling, M. W. Kieran, J. E. Bradner, O. Maher, S. Khatua, N. Tarek, W. Zaky, T. Gupta, S. Mohanty, S. Kannan, R. Jalali, E. Kapitza, D. Denkhaus, A. z. Muhlen, D. G. van Vuurden, M. Garami, J. Fangusaro, T. B. Davidson, M. J. G. da Costa, J. Sterba, S. C. Clifford, J. L. Finlay, R. Schmidt, J. Felsberg, H. Skladny, F. Cremer, G. Reifenberger, R. Kunder, E. Sridhar, A. A. Moiyadi, A. Goel, N. Goel, N. Shirsat, R. Othman, L. Storer, I. Kerr, B. Coyle, N. Law, M. L. Smith, M. Greenberg, S. Laughlin, D. Malkin, F. Liu, I. Moxon-Emre, N. Scantlebury, A. Nasir, D. Onion, A. Lourdusamy, A. Grabowska, Y. Cai, T. Bradshaw, R. S. S. de Medeiros, A. Beaugrand, S. Soares, S. Epelman, W. Wang, M. Sultan, R. J. Wechsler-Reya, M. Zapatka, B. Radlwimmer, D. Alderete, L. Baroni, F. Lubinieki, F. Auad, M. L. Gonzalez, W. Puya, P. Pacheco, O. Aurtenetxe, A. Gaffar, L. Gros, O. Cruz, C. Calvo, N. Shinojima, H. Nakamura, J.-i. Kuratsu, A. Hanaford, C. Eberhart, T. Archer, P. Tamayo, S. Pomeroy, E. Raabe, K. De Braganca, S. Gilheeney, Y. Khakoo, K. Kramer, S. Wolden, I. Dunkel, R. R. Lulla, J. Laskowski, S. Goldman, V. Gopalakrishnan, D. Shih, X. Wang, C. Faria, C. Raybaud, U. Tabori, J. Rutka, S. Jacobs, F. De Vathaire, I. Diallo, D. Llanas, C. Verez, F. Diop, A. Kahlouche, S. Puget, E. Thompson, E. Prince, V. Amani, P. Sin-Chan, M. Lu, C. Kleinman, T. Spence, D. Picard, K. C. Ho, J. Chan, J. Majewski, N. Jabado, P. Dirks, A. Huang, J. R. Madden, A. M. Donson, D. M. Mirsky, A. Dubuc, S. Mack, D. Gendoo, B. Luu, T. MacDonald, T. Van Meter, S. Croul, A. Laureano, W. Brugmann, C. Denman, H. Singh, H. Huls, J. Moyes, D. Sandberg, L. Silla, L. Cooper, and D. Lee
- Subjects
Oncology ,Abstracts ,Cancer Research ,medicine.medical_specialty ,Cns pnet ,business.industry ,Internal medicine ,Meta-analysis ,medicine ,Neurology (clinical) ,business - Published
- 2014
5. LAB-EXPERIMENTAL (PRE-CLINICAL) THERAPEUTICS AND PHARMACOLOGY
- Author
-
F. H. Yang, B. Zhang, D. J. Zhou, L. Bie, M. W. Tom, D. C. Drummond, T. Nicolaides, S. Mueller, A. Banerjee, J. W. Park, M. D. Prados, D. C. James, N. Gupta, R. Hashizume, G. W. Strohbehn, J. Zhou, M. Fu, T. R. Patel, J. M. Piepmeier, W. M. Saltzman, Q. Xie, J. Johnson, R. Bradley, M. L. Ascierto, L. Kang, J. Koeman, F. M. Marincola, M. Briggs, K. Tanner, G. F. Vande Woude, S. Tanaka, L. K. Klofas, H. Wakimoto, D. R. Borger, A. J. Iafrate, T. T. Batchelor, A. S. Chi, A. B. Madhankumar, B. Slagle-Webb, E. Rizk, K. Harbaugh, J. R. Connor, G. Sarkar, G. L. Curran, R. B. Jenkins, K. Kurozumi, T. Ichikawa, M. Onishi, K. Fujii, J. Ishida, Y. Shimazu, I. Date, K. Ebsworth, M. J. Walters, L. S. Ertl, Y. Wang, R. D. Berahovich, P. Zhang, J. P. Powers, S.-C. Liu, R. Al Omran, T. J. Sullivan, J. C. Jaen, M. Brown, T. J. Schall, N. Yusuke, S. Shimizu, Y. Shishido-Hara, Y. Shiokawa, M. Nagane, J. Wang, K. Sai, F.-R. Chen, Z.-P. Chen, Z. Shi, J. Zhang, K. Zhang, L. Han, L. Chen, X. Qian, A. Zhang, G. Wang, Z. Jia, P. Pu, C. Kang, L.-Y. Kong, T. A. Doucette, S. D. Ferguson, J. Hachem, Y. Yang, J. Wei, W. Priebe, G. N. Fuller, W. Qiao, G. Rao, A. B. Heimberger, P.-Y. Chen, T. Ozawa, D. Drummond, R. Santos, J. D. Torre, C. Ng, E. L. Lepe, N. Butowski, M. Prados, K. Bankiewicz, C. D. James, Z. Cheng, Y. Gong, Y. Ma, S. Muller-Knapp, S. Knapp, E. Antonio Chiocca, B. Kaur, J. S. Yu, V. Judkowski, A. Bunying, J. Ji, Z. Li, J. Bender, C. Pinilla, V. Srinivasan, M. Dombovy-Johnson, E. Carson-Walter, K. Walter, Z. Xu, B. Popp, D. Schlesinger, L. Gray, J. Sheehan, S. T. Keir, H. S. Friedman, D. D. Bigner, C. Kut, B. Tyler, E. McVeigh, X. Li, D. Herzka, S. Grossman, J. L. Lasky, E. Panosyan, W. H. Meisen, J. Hardcastle, J. Wojton, E. Wohleb, C. Alvarez-Breckenridge, M. Nowicki, J. Godbout, S. Y. Lee, J. M. Sheehan, S. Yin, S. Kaluz, S. N. Devi, R. de Noronha, K. C. Nicolaou, E. G. Van Meir, J. E. Lachowicz, M. Demeule, C. Che, S. Tripathy, S. Jarvis, J.-C. Currie, A. Regina, T. Nguyen, J.-P. Castaigne, K. Zielinska-Chomej, C. Mohanty, K. Viktorsson, R. Lewensohn, J. J. Driscoll, S. Alsidawi, R. E. Warnick, O. Rixe, A. C. deCarvalho, S. Irtenkauf, L. Hasselbach, H. Xin, T. Mikkelsen, J. H. Sherman, A. Siu, O. Volotskova, M. Keidar, D. M. Gibo, P. Dickinson, J. Robertson, J. Rossmeisl, W. Debinski, S. Nair, R. Schmittling, D. Boczkowski, G. Archer, J. H. Sampson, D. A. Mitchell, I. S. Miller, S. Didier, D. W. Murray, M. Issaivanan, S. J. Coniglio, J. E. Segall, Y. Al-Abed, M. Symons, A. Fotovati, K. Hu, J. Triscott, J. Bacha, D. M. Brown, S. E. Dunn, D. J. Daniels, T. E. Peterson, A. B. Dietz, G. J. Knutson, I. F. Parney, R. J. Diaz, B. Golbourn, D. Picard, C. Smith, A. Huang, J. Rutka, N. Saito, J. Fu, J. Yao, S. Wang, D. Koul, W. K. A. Yung, Y. Yuan, E. P. Sulman, H. Colman, F. F. Lang, E. A. Slat, E. D. Herzog, J. B. Rubin, A. S. Carminucci, B. Amendolara, R. Leung, L. Lei, P. Canoll, J. N. Bruce, J. A. Wojton, Z. Chu, C.-H. Kwon, L. M. Chow, M. Palascak, R. Franco, T. Bourdeau, S. Thornton, X. Qi, G. J. Kitange, A. C. Mladek, D. Su, B. L. Carlson, M. A. Schroeder, J. L. Pokorny, K. K. Bakken, S. K. Gupta, P. A. Decker, W. Wu, J. N. Sarkaria, M. P. Oddou, A. Mollard, L. T. Call, H. Vakayalapati, S. L. Warner, S. Sharma, D. J. Bearss, T. C. Chen, H. Cho, W. Wang, F. M. Hofman, C. T. Flores, D. Snyder, L. Sanchez-Perez, C. Pham, H. Friedman, E. Woolf, M. G. Abdelwahab, G. Turner, M. C. Preul, A. Lynch, J. M. Rho, A. C. Scheck, L. Salphati, T. P. Heffron, B. Alicke, K. Barck, R. A. Carano, J. Cheong, J. Greve, L. B. Lee, M. Nishimura, J. Pang, E. G. Plise, H. B. Reslan, X. Zhang, S. G. GOuld, A. G. Olivero, H. S. Phillips, G. Zadeh, S. Jalali, D. Voce, Z. Wei, K. Shijun, K. Nikolai, W. Josh, C. Clayton, Y. Bakhtiar, R. Alkins, A. Burgess, M. Ganguly, W. Wels, K. Hynynen, Y. M. Li, H. Jun, V. Daniel, H. A. Walter, H. Nakashima, T. T. Nguyen, I. Shalkh, W. F. Goins, E. A. Chiocca, I. V. Pyko, M. Nakada, N. Furuyama, T. Lei, Y. Hayashi, K. Kawakami, T. Minamoto, A. S. Fedulau, and J.-i. Hamada
- Subjects
Cancer Research ,Microarray analysis techniques ,Cell ,technology, industry, and agriculture ,Pharmacology ,Biology ,Molecular biology ,Abstracts ,medicine.anatomical_structure ,Oncology ,Targeted drug delivery ,Apoptosis ,Gene expression ,Cancer cell ,medicine ,Neurology (clinical) ,KEGG ,Regulator gene - Abstract
Ginsenoside Rg3 is a natural active ingredient that is extracted from Korean red ginseng root. It elevates the therapeutic effect of radiotherapy and chemotherapy, but previous studies found that the application of Rg3 is heavily limited by its low bioavailability and poor absorption via oral administration. To overcome these problems, Rg3-loaded PEG-PLGA-NPs (Rg3-NPs) were prepared by the modified spontaneous emulsification solvent diffusion (SESD) method, and the physicochemical characteristics of Rg3-NPs were investigated. We treated primary glioblastoma with 50 mM Rg3-NPs for 48h. We then used gene expression arrays (Illumina) for genome-wide expression analysis and validated the results for genes of interest by means of real-time PCR. Functional annotations were then performed using the DAVID and KEGG online tools. The results showed that the Rg3-NPs are slick and uniform, the average diameter of the nanoparticles is 75-90 nm, and their entrapment efficiency is 89.7+1.7%. MTT showed that the growth of cells can be significantly inhibited by Rg3-NPs in a dose-dependent manner. FCM testing showed Rg3-NPs can be released from the conjugate nanoparticle and react with the genes in the cell nuclei, causing changes in the gene molecules. We also found that cancer cells treated with Rg3-NPs undergo cell-cycle arrest at different checkpoints. This arrest was associated with a decrease in the mRNA levels of core regulatory genes BUB1, CDC20, TTK, and CENPE, as determined by microarray analysis and verified by real-time PCR. Furthermore, Rg3-NPs induced the expression of the apoptotic and antimigratory protein p53 in cell lines. The results of the present study, together with the results of earlier studies, show that Rg3-NPs target genes involved in theprogressionoftheM-phaseofthecellcycle.Itisassociatedwithseveralimportant pathways, which include apoptosis (p53). Rg3-NPs may be a potent cell-cycle regulation drug targeting the M-phase in glioblastoma cell lines.
- Published
- 2012
6. HIGH GRADE GLIOMAS
- Author
-
A. Leonard, J. Wolff, R. Sengupta, J. Marassa, D. Piwnica-Worms, J. Rubin, I. Pollack, R. Jakacki, L. Butterfield, H. Okada, J. Fangusaro, K. E. Warren, C. Mullins, P. Jurgen, S. Julia, C. C. Friedrich, S. Keir, J. Saling, M. Roskoski, H. Friedman, D. Bigner, C. Moertel, M. Olin, T. Dahlheimer, M. Gustafson, D. Sumstad, D. McKenna, W. Low, D. Nascene, A. Dietz, J. Ohlfest, D. Sturm, H. Witt, V. Hovestadt, D. A. K. Quan, D. T. W. Jones, C. Konermann, E. Pfaff, A. Korshunov, M. Rizhova, T. Milde, O. Witt, M. Zapatka, V. P. Collins, M. Kool, G. Reifenberger, P. Lichter, A. M. Lindroth, C. Plass, N. Jabado, S. M. Pfister, B. Pizer, A. Salehzadeh, A. Brodbelt, C. Mallucci, M. Brassesco, J. Pezuk, A. Morales, J. de Oliveira, G. Roberto, K. Umezawa, E. Valera, E. Rego, C. Scrideli, L. Tone, S. J. E. Veringa, D. G. Van Vuurden, P. Wesseling, W. P. Vandertop, D. P. Noske, T. Wurdinger, G. J. L. Kaspers, E. Hulleman, K. Wright, A. Broniscer, A. Bendel, D. Bowers, J. Crawford, P. Fisher, T. Hassall, G. Armstrong, J. Baker, I. Qaddoumi, G. Robinson, C. Wetmore, P. Klimo, F. Boop, A. Onar-Thomas, D. Ellison, A. Gajjar, O. Cruz, C. de Torres, M. Sunol, E. Rodriguez, L. Alonso, A. Parareda, T. Cardesa, H. Salvador, V. Celis, A. Guillen, G. Garcia, J. Muchart, C. Trampal, M. L. Martin, M. Rebollo, J. Mora, A. Piotrowski, A. Kowalska, P. Coyle, S. Smith, H. Rogers, D. Macarthur, R. Grundy, D. Puccetti, S. Salamat, T. Kennedy, N. Patel, K. Bradley, K. Casey, B. Iskandar, Y. Nakano, K. Okada, Y. Osugi, K. Yamasaki, H. Fujisaki, H. Fukushima, T. Inoue, Y. Matsusaka, H. Sakamoto, J. Hara, S. De Vleeschouwer, H. Ardon, F. Van Calenbergh, R. Sciot, G. Wilms, J. Van Loon, J. Goffin, S. Van Gool, D. Rusinak, P. Knight, K. Onel, D. Wargowski, A. Stettner, A. Al-Ghafari, W. Punjaruk, B. Coyle, I. Kerr, E. Xipell, M. Rodriguez, M. Gonzalez-Huarriz, M. T. Tunon, I. Zazpe, S. Tejada-Solis, R. Diez-Valle, J. Fueyo, C. Gomez-Manzano, M. M. Alonso, D. Pastakia, C. McCully, R. Murphy, J. Bacher, M. Thomas, E. Steffen-Smith, K. Saleem, S. Waldbridge, B. Widemann, K. Warren, E. Miele, F. Buttarelli, A. Arcella, F. Begalli, A. Po, C. Baldi, G. Carissimo, M. Antonelli, V. Donofrio, I. Morra, P. Nozza, A. Gulino, F. Giangaspero, E. Ferretti, I. Elens, F. Pauwels, S. Fritzell, S. Eberstal, E. Sanden, E. Visse, A. Darabi, P. Siesjo, P. McDonald, J. Wrogemann, S. Krawitz, M. Del Bigio, D. Eisenstat, R. Kwiecien, T. Pietsch, A. Faldum, R.-D. Kortmann, M. Warmuth-Metz, S. Rutkowski, I. Slavc, C. M. Kramm, U. Uparkar, R. Geyer, R. Ermoian, R. Ellenbogen, S. Leary, J. Triscott, K. Hu, A. Fotovati, S. Yip, R. Kast, B. Toyota, S. Dunn, M. Hegde, A. Corder, K. Chow, M. Mukherjee, A. Ashoori, V. Brawley, H. Heslop, S. Gottschalk, E. Yvon, N. Ahmed, T.-T. Wong, F.-Y. Yang, M. Lu, H.-F. Liang, H.-E. Wang, R.-S. Liu, M.-C. Teng, C.-C. Yen, S. Agnihotri, C. Ternamian, C. Jones, G. Zadeh, J. Rutka, C. Hawkins, I. Filipek, M. Drogosiewicz, M. Perek-Polnik, E. Swieszkowska, B. D. Baginska, E. Jurkiewicz, D. Perek, A. Kuehn, F. Falkenstein, A. Gnekow, C. Kramm, M. D. Brooks, E. Jackson, R. D. Mitra, J. B. Rubin, X.-Y. Liu, J. Schwartzentruber, A. M. Fontebasso, D.-A. K. Quang, S. Albrecht, Z. Dong, P. Siegel, A. Von Diemling, D. Faury, U. Tabori, J. Majewski, R. Lulla, M. Echevarria, T. Alden, A. DiPatri, T. Tomita, S. Goldman, T. Lin, T. E. Merchant, M. Kocak, A. P. Panandiker, G. T. Armstrong, G. H. Gielen, A. z. Muehlen, C. Hubert, Y. Ding, C. Toledo, P. Paddison, J. Olson, M. Nandhabalan, L. Bjerke, D. Bax, D. Carvalho, I. Bajrami, A. Ashworth, C. Lord, D. Hargrave, R. Reis, P. Workman, S. Little, S. Popov, A. Jury, A. Burford, L. Doey, S. Al-Sarraj, J. Jurgensmeier, L. Chen, I. Kozarewa, S. Baker, L. Perryman, G. Box, F. Raynaud, S. Eccles, M. Viana-Pereira, M. Pereira, T. Forshew, R. Tatevossian, D. Sheer, J. Pimental, M. Pires, C. Sarkar, P. Jha, I. R. P. Patrick, K. Somasundaram, P. Pathak, M. C. Sharma, V. Suri, A. Suri, N. Gerges, T. Haque, A. Nantel, C. Lee, J. Chen, C. Venugopal, A. Singhal, C. Dunham, J. Kerr, M. Verreault, H. Wakimoto, A. Jayanthan, A. Narendran, S. Singh, G. Giraud, S. Holm, B. Gustavsson, R. Kizyma, Z. Kizyma, L. Dvornyak, B. Kotsay, S. Epari, P. Sharma, M. Gurav, T. Gupta, P. Shetty, A. Moiyadi, S. Kane, and R. Jalali
- Subjects
Abstracts ,03 medical and health sciences ,Cancer Research ,0302 clinical medicine ,Oncology ,business.industry ,030220 oncology & carcinogenesis ,Medicine ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Published
- 2012
7. PRECLINICAL EXPERIMENTAL THERAPEUTICS AND PHARMACOLOGY
- Author
-
H. Pavel, N. Ajeawung, R. Faure, D. Poirier, D. Kamnasaran, H. Joshi, X. Lun, F. Zemp, B. Sun, O. Stechishin, A. Luchman, J. J. Kelly, S. Weiss, M. G. Hamilton, G. Cairncross, D. L. Senger, J. Bell, G. McFadden, P. A. Forsyth, S. Y. Tzeng, H. Guerrero-Cazares, E. E. Martinez, N. P. Young, J. C. Sunshine, A. Quinones-Hinojosa, J. J. Green, L. Lei, R. D'Amico, J. Sisti, R. Leung, A. M. Sonabend, P. Guarnieri, S. S. Rosenfeld, J. N. Bruce, P. Canoll, V. R. Baichwal, L. Reeves, B. L. Chad, K. H. Zavitz, A. P. Beelen, G. G. Mather, R. O. Carlson, C. Manton, J. Chandra, S. T. Keir, D. A. Reardon, J. R. Saling, L. S. Gray, D. D. Bigner, H. S. Friedman, J. Zhang, J. Brun, H. Ogbomo, Z. Wang, D. J. Stojdl, L.-Y. Kong, M. A. Hatiboglu, J. Wei, Y. Wang, K. A. McEnery, G. N. Fuller, W. Qiao, M. A. Davies, W. Priebe, A. B. Heimberger, B. Amendolara, O. Gil, S. Ivkovic, J. Bruce, S. Rosenfeld, S. Finniss, B. Perlstein, C. Miller, H. Okhrimenko, G. Kazimirsky, S. Cazacu, N. Lemke, S. Brodie, S. A. Rempel, M. Rosenblum, T. Mikkelsen, S. Margel, C. Brodie, H. Guvenc, H. Demir, S. Gupta, S. Mazumder, A. Ray-Chaundhury, T. Li, C. Li, I. Nakano, R. Rahman, C. Rahman, S. Smith, D. Macarthur, F. Rose, K. Shakesheff, R. G. Grundy, A. J. Brenner, B. Goins, A. Bao, J. Miller, A. Trevino, R. Zuniga, W. T. Phillips, A. G. Gilg, K. G. Bowers, B. P. Toole, B. L. Maria, G. K. Leung, S. Sun, S. T. Wong, X. Q. Zhang, J. K. Pu, W. M. Lui, A. M. Marino, I. M. Hussaini, S. Amos, K. Simpson, G. T. Redpath, C. Lyons, C. Dipierro, G. A. Grant, C. Wilson, S. Salami, P. Macaroni, S. Li, J.-Y. Park, D. Needham, D. Bigner, M. Dewhirst, J. Ohlfest, J. Gallardo, S. Argawal, R. Mittapalli, R. Donelson, W. F. Elmquist, T. Nicolaides, S. Hariono, K. Barkovich, R. Hashizume, D. Rowitch, W. Weiss, D. Sheer, S. Baker, B. Paugh, T. Waldman, H. Li, C. Jones, T. Forshew, D. James, H. Caroline, R. Patrick, L. Katrin, F. Karl, T. Ghazaleh, W. Michael, V. Albrecht, J. Thorsteinsdottir, E. Wagner, J.-C. Tonn, M. Ogris, C. Schichor, G. Charest, B. Paquette, L. Sanche, D. Mathieu, D. Fortin, X. Qi, F. Cuttitta, Z. Chu, J. Celerier, J. Pakradouni, O. Rixe, A. Gragg, S. Muller, A. Banerjee, J. Phillips, M. Prados, D. Haas-Kogan, N. Gupta, L. Florence, V. G. Gwendoline, M. Veronique, K. Robert, S. Agarwal, R. K. Mittapalli, L. Cen, B. L. Carlson, J. N. Sarkaria, S. Sengupta, S. D. Weeraratne, S. Rallapalli, V. Amani, J. Pierre-Francois, N. Teider, A. Rotenberg, J. Cook, S. L. Pomeroy, F. Jenses, Y.-J. Cho, M. Hjouj, D. Last, D. Guez, D. Daniels, J. Lavee, B. Rubinsky, Y. Mardor, L. P. Serwer, C. O. Noble, K. Michaud, D. C. Drummond, T. Ozawa, Y. Zhou, J. D. Marks, K. Bankiewicz, J. W. Park, W. Wang, H. Cho, M. Weintraub, N. Jhaveri, S. Torres, N. Petasis, A. H. Schonthal, S. G. Louie, F. M. Hofman, T. C. Chen, Z. Grada, M. Hegde, D. R. Schaffer, A. Ghazi, T. Byrd, G. Dotti, W. Wels, H. E. Heslop, S. Gottschalk, M. Baker, N. Ahmed, K. J. Hamblett, C. J. Kozlosky, H. Liu, S. Siu, T. Arora, M. W. Retter, K. Matsuda, J. S. Hill, W. C. Fanslow, R. J. Diaz, A. Etame, O. Meaghan, T. Mainprize, C. Smith, K. Hynynen, J. Rutka, J. Pradarelli, J. Y. Yoo, A. Kaka, C. Alvarez-Breckenridge, Q. Pan, E. A. Chiocca, T. Teknos, B. Kaur, S. Y. Lee, B. Slagle-Webb, J. M. Sheehan, J. R. Connor, J. Cote, M. Lepage, F. Gobeil, A. Kleijn, R. Balvers, J. Kloezeman, C. Dirven, M. Lamfers, S. Leenstra, W. See, I.-L. Tan, R. Pieper, H. Jiang, E. White, C. I. Rios-Vicil, W.-K. A. Yung, C. Gomez-Manzano, J. Fueyo, F. J. Zemp, B. A. McKenzie, S. Mueller, X. Yang, I. Smirnov, D. C. James, J. J. Phillips, M. S. Berger, D. H. Rowitch, D. H. Haas-Kogan, B. Kennedy, V. Gopalakrishnan, C. Das, P. Taylor, R. Kommagani, X. Su, D. Aguilera, A. Thomas, J. Wolff, E. Flores, M. Kadakia, R. Alkins, P. Broderson, R. Sodhi, S. A. Chung, K. L. McDonald, H. Shen, B. W. Day, B. W. Stringer, T. Johns, S. Decollogne, C. Teo, P. J. Hogg, P. J. Dilda, T. R. Patel, J. Zhou, J. M. Piepmeier, W. M. Saltzman, M. A. Vogelbaum, P. Manchanda, J. R. Ohlfest, G. J. Kitange, A. C. Mladek, M. A. Schroeder, J. L. Pokorny, C. Mody, P. Forsyth, T. Dasgupta, C. D. James, A. B. Madhankumar, B. S. Webb, A. Park, K. Harbaugh, and J. Sheehan
- Subjects
Abstracts ,Cancer Research ,Oncology ,business.industry ,Medicine ,Neurology (clinical) ,Pharmacology ,business - Abstract
The 16th Annual Scientific Meeting of the Society for Neuro-Oncology in Conjunction with the AANS/CNS Section on Tumors, Orange County, California, USA, 17-20 November 2011. In Neuro-Oncology, 2011, v. 13 n. Suppl. 3, p. iii111, abstract no. ET-18
- Published
- 2011
8. HIGH GRADE GLIOMAS AND DIPG
- Author
-
C. F. Classen, D. William, M. Linnebacher, A. Farhod, W. Kedr, B. Elsabe, S. Fadel, S. Van Gool, S. De Vleeschouwer, C. Koks, A. Garg, M. Ehrhardt, M. Riva, P. Agostinis, N. Graf, T.-W. Yao, Y. Yoshida, J. Zhang, T. Ozawa, D. James, T. Nicolaides, R. Kebudi, F. B. Cakir, O. Gorgun, F. Y. Agaoglu, E. Darendeliler, A. Al-Kofide, E. Al-Shail, Y. Khafaga, H. Al-Hindi, M. Dababo, A. U. Haq, M. Anas, M. G. Barria, K. Siddiqui, M. Hassounah, M. Ayas, S. V. van Zanten, M. Jansen, D. van Vuurden, M. Huisman, D. Vugts, O. Hoekstra, G. van Dongen, G. Kaspers, J. Cockle, E. Ilett, K. Scott, A. Bruning-Richardson, S. Picton, S. Short, A. Melcher, M. Benesch, M. Warmuth-Metz, A. O. von Bueren, M. Hoffmann, T. Pietsch, R.-D. Kortmann, M. Eyrich, S. Rutkowski, M. C. Fruhwald, J. Faber, C. Kramm, M. Porkholm, L. Valanne, T. Lonnqvist, S. Holm, B. Lannering, P. Riikonen, D. Wojcik, A. Sehested, N. Clausen, A. Harila-Saari, E. Schomerus, H. K. Thorarinsdottir, P. Lahteenmaki, M. Arola, H. Thomassen, U. M. Saarinen-Pihkala, S.-M. Kivivuori, P. Buczkowicz, C. Hoeman, P. Rakopoulos, S. Pajovic, A. Morrison, E. Bouffet, U. Bartels, O. Becher, C. Hawkins, T. W. A. Gould, C. V. Rahman, S. J. Smith, D. A. Barrett, K. M. Shakesheff, R. G. Grundy, R. Rahman, N. Barua, D. Cronin, S. Gill, S. Lowisl, A. Hochart, C.-A. Maurage, N. Rocourt, M. Vinchon, O. Kerdraon, F. Escande, J. Grill, V. K. Pick, P. Leblond, G. Burzynski, T. Janicki, S. Burzynski, A. Marszalek, N. Ramani, W. Zaky, G. Kannan, A. Morani, D. Sandberg, L. Ketonen, O. Maher, F. Corrales-Medina, H. Meador, S. Khatua, M. Brassesco, L. Delsin, G. Roberto, C. Silva, L. Ana, E. Rego, C. Scrideli, K. Umezawa, L. Tone, S. J. Kim, C.-Y. Kim, I.-A. Kim, J. H. Han, B.-S. Choi, H. S. Ahn, H. S. Choi, F. Haque, R. Layfield, R. Grundy, L. Gandola, E. Pecori, V. Biassoni, E. Schiavello, C. Chiruzzi, F. Spreafico, P. Modena, F. Bach, E. Pignoli, M. Massimino, M. Drogosiewicz, B. Dembowska-Baginska, E. Jurkiewicz, I. Filipek, M. Perek-Polnik, E. Swieszkowska, D. Perek, S. Bender, D. T. Jones, H.-J. Warnatz, B. Hutter, T. Zichner, J. Gronych, A. Korshunov, R. Eils, J. O. Korbel, M.-L. Yaspo, P. Lichter, S. M. Pfister, S. Yadavilli, O. J. Becher, M. Kambhampati, R. J. Packer, J. Nazarian, F. C. Lechon, L. Fowkes, K. Khabra, L. M. Martin-Retortillo, L. V. Marshall, S. Vaidya, D.-M. Koh, M. O. Leach, A. D. Pearson, S. Zacharoulis, D. Schrey, G. Barone, E. Panditharatna, M. Stampar, A. Siu, H. Gordish-Dressman, J. Devaney, E. I. Hwang, A. H. Chung, R. K. Mittapalli, W. F. Elmquist, D. Castel, M.-A. Debily, C. Philippe, N. Truffaux, K. Taylor, R. Calmon, N. Boddaert, L. Le Dret, P. Saulnier, L. Lacroix, A. Mackay, C. Jones, S. Puget, C. Sainte-Rose, T. Blauwblomme, P. Varlet, N. Entz-Werle, C. Maugard, G. Bougeard, A. Nguyen, M. P. Chenard, A. Schneider, M. P. Gaub, M. Tsoli, A. Vanniasinghe, P. Luk, P. Dilda, M. Haber, P. Hogg, D. Ziegler, S. Simon, M. Monje, K. Gurova, A. Gudkov, M. Zapotocky, M. Churackova, B. Malinova, J. Zamecnik, M. Kyncl, M. Tichy, A. Puchmajerova, J. Stary, D. Sumerauer, J. Boult, M. Vinci, L. Perryman, G. Box, A. Jury, S. Popov, W. Ingram, S. Eccles, S. Robinson, S. Emir, H. A. Demir, C. Bayram, F. Cetindag, G. B. Kabacam, A. Fettah, J. Li, Y. Jamin, C. Cummings, J. Bamber, R. Sinkus, M. Nandhabalan, L. Bjerke, A. Burford, A. von Bueren, M. Baudis, P. Clarke, I. Collins, P. Workman, N. Olaciregui, J. Mora, A. Carcaboso, A. Bullock, M. Alonso, C. de Torres, O. Cruz, E. Pencreach, F. M. Moussalieh, D. Guenot, I. Namer, I. Pollack, R. Jakacki, L. Butterfield, R. Hamilton, A. Panigrahy, D. Potter, A. Connelly, S. Dibridge, T. Whiteside, H. Okada, S. Ahsan, E. Raabe, M. Haffner, K. Warren, M. Quezado, L. Ballester, C. Eberhart, F. Rodriguez, C. Ramachandran, S. Nair, K.-W. Quirrin, Z. Khatib, E. Escalon, S. Melnick, M. Hofmann, I. Schmid, T. Simon, E. Maass, A. Russo, G. Fleischhack, M. Becker, H. Hauch, A. Sander, C. Grasso, N. Berlow, L. Liu, L. Davis, E. Huang, P. Woo, Y. Tang, A. Ponnuswami, S. Chen, Y. Huang, M. Hutt-Cabezas, L. Dret, P. Meltzer, H. Mao, J. Abraham, M. Fouladi, M. N. Svalina, N. Wang, E. Hulleman, X.-N. Li, C. Keller, P. T. Spellman, R. Pal, M. H. A. Jansen, A. C. P. Sewing, T. Lagerweij, D. J. Vuchts, D. G. van Vuurden, V. Caretti, P. Wesseling, G. J. L. Kaspers, K. Cohen, M. Pearl, M. Kogiso, L. Zhang, L. Qi, H. Lindsay, F. Lin, S. Berg, J. Muscal, N. Amayiri, U. Tabori, B. Campbel, D. Bakry, M. Aronson, C. Durno, S. Gallinger, D. Malkin, I. Qaddumi, A. Musharbash, M. Swaidan, M. Al-Hussaini, S. Shandilya, C. McCully, R. Murphy, S. Akshintala, D. Cole, R. P. Macallister, R. Cruz, B. Widemann, R. Salloum, A. Smith, M. Glaunert, A. Ramkissoon, S. Peterson, S. Baker, L. Chow, J. Sandgren, S. Pfeifer, S. Popova, I. Alafuzoff, T. D. de Stahl, S. Pietschmann, M. J. Kerber, I. Zwiener, G. Henke, K. Muller, N. Y.-F. Sieow, R. H. M. Hoe, A. M. Tan, M. Y. Chan, S. Y. Soh, K. Burrell, Y. Chornenkyy, M. Remke, B. Golbourn, M. Barzczyk, M. Taylor, J. Rutka, P. Dirks, G. Zadeh, S. Agnihotri, R. Hashizume, Y. Ihara, N. Andor, X. Chen, R. Lerner, X. Huang, M. Tom, D. Solomon, S. Mueller, C. Petritsch, Z. Zhang, N. Gupta, T. Waldman, A. Dujua, J. Co, F. Hernandez, D. Doromal, M. Hegde, A. Wakefield, V. Brawley, Z. Grada, T. Byrd, K. Chow, S. Krebs, H. Heslop, S. Gottschalk, E. Yvon, N. Ahmed, G. Cornilleau, J. Paulsson, F. Andreiuolo, L. Guerrini-Rousseau, B. Geoerger, G. Vassal, A. Ostman, D. W. Parsons, L. R. Trevino, F. Gao, X. Shen, O. Hampton, M. Kosigo, P. A. Baxter, J. M. Su, M. Chintagumpala, R. Dauser, A. Adesina, S. E. Plon, D. A. Wheeler, C. C. Lau, G. Gielen, A. z. Muehlen, R. Kwiecien, J. Wolff, R. R. Lulla, J. Laskowski, S. Goldman, V. Gopalakrishnan, J. Fangusaro, M. Kieran, A. Fontebasso, S. Papillon-Cavanagh, J. Schwartzentruber, H. Nikbakht, N. Gerges, P.-O. Fiset, D. Bechet, D. Faury, N. De Jay, L. Ramkissoon, A. Corcoran, D. Jones, D. Sturm, P. Johann, T. Tomita, M. Nagib, A. Bendel, L. Goumnerova, D. C. Bowers, J. R. Leonard, J. B. Rubin, T. Alden, A. DiPatri, S. Browd, S. Leary, G. Jallo, M. D. Prados, A. Banerjee, A.-S. Carret, B. Ellezam, L. Crevier, A. Klekner, L. Bognar, P. Hauser, M. Garami, J. Myseros, Z. Dong, P. M. Siegel, W. Gump, K. Ayyanar, J. Ragheb, M. Krieger, E. Kiehna, N. Robison, D. Harter, S. Gardner, M. Handler, N. Foreman, B. Brahma, T. MacDonald, H. Malkin, S. Chi, P. Manley, P. Bandopadhayay, L. Greenspan, A. Ligon, S. Albrecht, K. L. Ligon, J. Majewski, N. Jabado, F. Cordero, K. Halvorson, I. Taylor, M. Hutt, M. Weingart, A. Price, M. Kantar, S. Onen, S. Kamer, T. Turhan, O. Kitis, Y. Ertan, N. Cetingul, Y. Anacak, T. Akalin, Y. Ersahin, G. Mason, C. Ho, F. Crozier, G. Vezina, R. Packer, E. Hwang, S. Gilheeney, N. Millard, K. DeBraganca, Y. Khakoo, K. Kramer, S. Wolden, M. Donzelli, C. Fischer, M. Petriccione, I. Dunkel, S. Afzal, A. Fleming, V. Larouche, S. Zelcer, D. L. Johnston, M. Kostova, C. Mpofu, J.-C. Decarie, D. Strother, L. Lafay-Cousin, D. Eisenstat, C. Fryer, J. Hukin, M. Hsu, J. Lasky, T. Moore, L. Liau, T. Davidson, R. Prins, T. Hassal, J. Baugh, J. Kirkendall, R. Doughman, J. Leach, B. Jones, L. Miles, D. Hargrave, T. Jacques, S. Savage, D. Saunders, R. Wallace, B. Flutter, D. Morgenestern, E. Blanco, K. Howe, M. Lowdell, E. Samuel, A. Michalski, J. Anderson, Y. Arakawa, K. Umeda, K.-i. Watanabe, T. Mizowaki, M. Hiraoka, H. Hiramatsu, S. Adachi, T. Kunieda, Y. Takagi, S. Miyamoto, S. Venneti, M. Santi, M. M. Felicella, L. M. Sullivan, I. Dolgalev, D. Martinez, A. Perry, P. W. Lewis, D. C. Allis, C. B. Thompson, and A. R. Judkins
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,business.industry ,03 medical and health sciences ,Abstracts ,0302 clinical medicine ,Text mining ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Published
- 2014
9. What would you do if you had a small vestibular schwannoma? An apocryphal tale
- Author
-
J. Rutka
- Subjects
Vestibular system ,Otorhinolaryngology ,business.industry ,medicine ,Anatomy ,Schwannoma ,medicine.disease ,business - Published
- 2008
10. PEDIATRICS LABORATORY RESEARCH
- Author
-
V. Caretti, A. Noll, P. Woo, M. Monje, J. Cockle, A. Bruning-Richardson, S. Picton, J. Levesley, E. Ilett, S. Short, A. Melcher, S. Lawler, L. Garzia, A. Dubuc, G. Pitcher, P. Northcott, A. Mariampillai, S. Mack, K. Zayne, T. Chan, P. Skowron, X. Wu, A. Lionel, S. Morrisy, C. Hawkins, P. Kongkham, J. Rutka, A. Huang, A. Kenney, V. Yang, M. Salter, M. Taylor, S. Jelveh, P. Lindsay, D. Largaespada, L. Collier, A. Dupuy, R. Hill, T.-H. Hsieh, H.-W. Wang, W.-C. Cheng, T.-T. Wong, X. Huang, Y. He, R. Hashizume, W. Zhang, S. Stehbens, S. Younger, S. Barshow, S. Zhu, S. Mueller, W. Weiss, D. James, M. Shuman, Y. N. Jan, L. Jan, M. Marigil, P. Jauregi, M. A. Idoate, E. Xipell, G. Aldave, M. Gonzalez-Huarriz, S. Tejada-Solis, R. Diez-Valle, A. Montero-Carcaboso, J. Mora, M. M. Alonso, K. Taylor, A. Mackay, N. Truffaux, O. Morozova, Y. Butterfield, C. Phillipe, M. Vinci, C. de Torres, O. Cruz, D. Hargrave, S. Puget, S. Yip, C. Jones, J. Grill, A. Kaul, Y.-H. Chen, S. Dahiya, R. Emnett, S. Gianino, D. Gutmann, T. Miwa, S. Oi, Y. Nonaka, H. Sasaki, K. Yoshida, E. Lopez, A. P. de Leon, C. Sepulveda, L. Zarate, J. Diego-Perez, W. Pong, L. Ding, M. McLellan, I. Hussain, S. Higer, J. Leonard, A. Guha, E. Mardis, C. Sarkar, P. Pathak, P. Jha, S. Purkait, V. Sharma, M. C. Sharma, V. Suri, M. Faruq, M. Mukherjee, B. Sivasankaran, R. P. Velayutham, I. R. Fraschilla, K. J. Morris, T. J. MacDonald, T.-A. Read, D. Sturm, D. Jones, A. Korshunov, D. Picard, P. Lichter, S. Pfister, M. Kool, T.-W. Yao, J. Zhang, B. Anna, T. Brummer, N. Gupta, T. Nicolaides, K.-M. Chan, D. Fang, H. Gan, C. Yu, M. Schroeder, R. Jenkins, J. Sarkaria, and Z. Zhang
- Subjects
Cancer Research ,Engineering ,Medical education ,Abstracts ,Oncology ,business.industry ,Neurology (clinical) ,business ,Laboratory research - Published
- 2013
11. STEM CELLS
- Author
-
L. Cheng, Z. Huang, W. Zhou, Q. Wu, J. Rich, S. Bao, P. Baxter, H. Mao, X. Zhao, Z. Liu, Y. Huang, H. Voicu, S. Gurusiddappa, J. M. Su, L. Perlaky, R. Dauser, H.-c. E. Leung, K. M. Muraszko, J. A. Heth, X. Fan, C. C. Lau, T.-K. Man, M. Chintagumpala, X.-N. Li, P. Clark, M. Zorniak, Y. Cho, X. Zhang, D. Walden, E. Shusta, J. Kuo, S. Sengupta, S. Goel-Bhattacharya, S. Kulkarni, B. Cochran, C. Cusulin, A. Luchman, S. Weiss, M. Wu, N. Fernandez, S. Agnihotri, R. Diaz, J. Rutka, M. Bredel, J. Karamchandani, S. Das, B. Day, B. Stringer, F. Al-Ejeh, M. Ting, J. Wilson, K. Ensbey, P. Jamieson, Z. Bruce, Y. C. Lim, C. Offenhauser, S. Charmsaz, L. Cooper, J. Ellacott, A. Harding, J. Lickliter, P. Inglis, B. Reynolds, D. Walker, M. Lackmann, A. Boyd, A. Berezovsky, L. Poisson, L. Hasselbach, S. Irtenkauf, A. Transou, T. Mikkelsen, A. C. deCarvalho, D. Emlet, C. Del Vecchio, P. Gupta, G. Li, S. Skirboll, A. Wong, J. Figueroa, T. Shahar, A. Hossain, F. Lang, S. Fouse, J. Nakamura, C. D. James, S. Chang, J. Costello, J. M. Frerich, S. Rahimpour, Z. Zhuang, J. D. Heiss, A. Golebiewska, D. Stieber, L. Evers, E. Lenkiewicz, N. H. C. Brons, N. Nicot, A. Oudin, S. Bougnaud, F. Hertel, R. Bjerkvig, M. Barrett, L. Vallar, S. P. Niclou, X. Hao, J. Rahn, E. Ujack, X. Lun, G. Cairncross, D. Senger, S. Robbins, J. Harness, R. Lerner, Y. Ihara, R. Santos, J. D. L. Torre, A. Lu, T. Ozawa, T. Nicolaides, D. James, C. Petritsch, D. Higgins, M. Schroeder, B. Ball, B. Milligan, F. Meyer, J. Sarkaria, J. Henley, W. Flavahan, M. Hitomi, N. Rahim, Y. Kim, A. Sloan, R. Weil, I. Nakano, M. Li, J. Lathia, A. Hjelmeland, M. Kaluzova, S. Platt, M. Kent, A. Bouras, R. Machaidze, C. Hadjipanayis, S.-G. Kang, S.-H. Kim, Y.-M. Huh, E.-H. Kim, E.-K. Park, J. H. Chang, S. H. Kim, Y. K. Hong, D. S. Kim, S.-J. Lee, E. H. Kim, S. G. Kang, L. Deleyrolle, M. Sinyuk, W. Goan, B. Otvos, M. Rohaus, M. Oli, V. Vedam-Mai, D. Schonberg, S.-T. Lee, K. Chu, S. K. Lee, M. Kim, J.-K. Roh, A. Griveau, B. Reichholf, M. McMahon, D. Rowitch, R. Nitta, S. Mitra, M. Agarwal, T. Bui, J. Lin, C. Adamson, J. Martinez-Quintanilla, S.-H. Choi, D. Bhere, P. Heidari, D. He, U. Mahmood, K. Shah, S. Gholamin, A. Feroze, A. Achrol, S. Kahn, I. Weissman, S. Cheshier, E. P. Sulman, Q. Wang, E. Mostovenko, H. Liu, C. F. Lichti, A. Shavkunov, R. A. Kroes, J. R. Moskal, C. A. Conrad, F. F. Lang, M. R. Emmett, C. L. Nilsson, S. Osuka, O. Sampetrean, T. Shimizu, I. Saga, N. Onishi, E. Sugihara, J. Okubo, S. Fujita, S. Takano, A. Matsumura, H. Saya, N. Saito, J. Fu, S. Wang, W. K. A. Yung, D. Koul, R. S. Schmid, D. M. Irvin, M. Vitucci, R. E. Bash, A. M. Werneke, C. R. Miller, N. Shinojima, T. Takezaki, J. Fueyo, J. Gumin, F. Gao, F. Nwajei, F. C. Marini, M. Andreeff, J.-I. Kuratsu, S. Singh, K. Burrell, E. Koch, S. Jalali, A. Vartanian, E. Sulman, B. Wouters, G. Zadeh, R. Spelat, E. Singer, L. Matlaf, S. McAllister, L. Soroceanu, S. Spiegl-Kreinecker, D. Loetsch, M. Laaber, C. Schrangl, A. Wohrer, J. Hainfellner, C. Marosi, J. Pichler, S. Weis, G. Wurm, G. Widhalm, E. Knosp, W. Berger, J.-i. Kuratsu, Q. Tam, S. Tanaka, M. Nakada, D. Yamada, T. Todo, Y. Hayashi, J.-i. Hamada, A. Hirao, J. Tilghman, M. Ying, J. Laterra, M. Venere, C. Chang, M. Summers, S. Rosenfeld, S. Luk, J. Iafrate, D. Cahill, R. Martuza, S. Rabkin, A. Chi, H. Wakimoto, H.-G. Wirsching, S. Krishnan, K. Frei, N. Krayenbuhl, G. Reifenberger, M. Weller, G. Tabatabai, J. Man, J. Shoemake, and J. Yu
- Subjects
Cancer Research ,Abstracts ,Oncology ,Neurology (clinical) - Published
- 2011
12. SECONDARY EPILEPTOGENESIS IN PATIENTS WITH LOCALIZATION RELATED EPILEPSY SECONDARY TO HISTOPATHOLOGICALLY PROVEN CORTICAL DYSPLASIAS
- Author
-
Ismail S. Mohamed, O. C. Snead, R. Sakuta, S. Manohar, H. Otsubo, S. Weiss, A. Ochi, J. Rutka, S. Chuang, and T. Akiyama
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,Pediatrics, Perinatology and Child Health ,medicine ,In patient ,Neurology (clinical) ,General Medicine ,Localization-related epilepsy ,business ,Epileptogenesis - Published
- 2006
13. SPATIO-TEMPORAL CHANGES OF ICTAL HIGH FREQUENCY OSCILLATIONS IN PEDIATRIC NEOCORTICAL EPILEPSY
- Author
-
I. Elliott, Elizabeth J. Donner, H. Otsubo, J. Rutka, O. C. Snead, and A. Ochi
- Subjects
business.industry ,Pediatrics, Perinatology and Child Health ,Medicine ,Ictal ,Neurology (clinical) ,General Medicine ,business ,Neocortical epilepsy ,Neuroscience - Published
- 2006
14. PREDICTORS OF POST-SURGICAL SEIZURE FREEDOM IN CHILDREN WITH NORMAL MRI AND INTRACTABLE EPILEPSY
- Author
-
A. Ochi, M. Shroff, Elizabeth J. Donner, S. Weiss, J. Rutka, R. R. Nair, O. C. Snead, and H. Otsubo
- Subjects
Post surgical ,Pediatrics ,medicine.medical_specialty ,business.industry ,Pediatrics, Perinatology and Child Health ,Intractable epilepsy ,Medicine ,Neurology (clinical) ,General Medicine ,Seizure freedom ,business ,Normal MRI - Published
- 2006
15. SECONDARY EPILEPTIC FOCI IN CHILDREN WITH INTRACTABLE EPILEPSY SECONDARY TO CORTICAL DYSPLASIAS
- Author
-
A. Ochi, O. C. Snead, M. Ismail, S. Manohar, R. Sakuta, O. Hiroshi, S. Chuang, S. Weiss, J. Rutka, and E. Galicia
- Subjects
Pediatrics ,medicine.medical_specialty ,business.industry ,Pediatrics, Perinatology and Child Health ,Intractable epilepsy ,Medicine ,Neurology (clinical) ,General Medicine ,Epileptic foci ,business - Published
- 2006
16. Role of transcription factors in the pathogenesis of pituitary adenomas: a review
- Author
-
A, Suhardja, K, Kovacs, and J, Rutka
- Subjects
Adenoma ,Leucine Zippers ,Binding Sites ,Amino Acid Motifs ,Helix-Loop-Helix Motifs ,Estrogen Receptor alpha ,Zinc Fingers ,DNA ,Neoplasm Proteins ,DNA-Binding Proteins ,Gene Expression Regulation, Neoplastic ,Proto-Oncogene Proteins c-myc ,Structure-Activity Relationship ,Receptors, Estrogen ,Humans ,Pituitary Neoplasms ,Transcription Factor Pit-1 ,Proto-Oncogene Proteins c-fos ,Transcription Factors - Abstract
The diversity inherent in every organ has its roots in gene-expression variation and is revealed through distinctions in the molecular profile and hence the identity of individual cell type. Study into the molecular mechanisms of the development of individual cell type within the pituitary, which is under the control of transcription factors, has provided a basis for a deeper insight into the molecular mechanisms underlying the pathogenesis of a variety of hormone-producing pituitary tumors. Identification of some of these transcription factors in pituitary adenomas further supports their role in the pathogenesis of pituitary adenomas. Understanding the molecular mechanisms of regulation of proliferation of pituitary cell types by transcription factors offers a basis for hope that rational genetic or pharmacologic therapies for pituitary tumors can be designed in the future.
- Published
- 2002
17. Genetic basis of pituitary adenoma invasiveness: a review
- Author
-
A, Suhardja, K, Kovacs, and J, Rutka
- Subjects
Adenoma ,DNA Mutational Analysis ,Genes, myc ,Antineoplastic Agents ,Retinoblastoma Protein ,Proto-Oncogene Proteins c-myc ,Proto-Oncogene Proteins p21(ras) ,Chromosomes, Human ,Humans ,Genes, Tumor Suppressor ,Neoplasm Invasiveness ,Pituitary Neoplasms ,Genes, Retinoblastoma ,Monomeric GTP-Binding Proteins ,Cell Cycle ,DNA, Neoplasm ,Genetic Therapy ,Oncogenes ,NM23 Nucleoside Diphosphate Kinases ,Genes, p53 ,Gene Expression Regulation, Neoplastic ,Cell Transformation, Neoplastic ,Genes, ras ,Drug Design ,Nucleoside-Diphosphate Kinase ,Mutation ,Disease Progression ,Tumor Suppressor Protein p53 ,Transcription Factors - Abstract
Compatible with contemporary paradigms of the role of genetic aberrations in the progression of human tumors, the growth of pituitary tumors into a state of invasiveness appears to be due to genetic alterations. Amplification of H-ras and c-myc oncogenes and mutations of p53, nm23 and Rb genes have been identified disproportionately more in aggressive tumors and, in the case of Rb gene, in pituitary carcinomas, providing evidence that amplification of these oncogenes (H-ras and c-myc) and inactivation of tumor suppressor genes (p53, nm23 and Rb) seem to be at least one mechanism by which pituitary tumors progress. The current level of management of invasive pituitary adenomas should become more comprehensive as the advances in our understanding of genetic basis of pituitary adenoma invasiveness becomes translated into development of novel chemotherapy or gene transfer technique.
- Published
- 2001
18. Adenoviral vector-mediated gene transfer: timing of wild-type p53 gene expression in vivo and effect of tumor transduction on survival in a rat glioma brachytherapy model
- Author
-
J, Bampoe, J, Glen, S L, Hubbard, B, Salhia, P, Shannon, J, Rutka, and M, Bernstein
- Subjects
Male ,Time Factors ,Brain Neoplasms ,Brachytherapy ,Genetic Vectors ,Gene Transfer Techniques ,Gene Expression ,Glioma ,Genes, p53 ,Survival Analysis ,Rats, Inbred F344 ,Adenoviridae ,Rats ,Animals ,Cell Division - Abstract
This study sought to investigate modification of the radiation response in a rat 9L brain tumor model in vivo by the wild-type p53 gene (wtp53). Determination of the timing and dose of radiation therapy required the assessment of the duration of the effect of wtp53 expression on 9L tumors after in vivo transfection.Anesthetized male F-344 rats each were stereotactically inoculated with 4 x 10(4) 9L gliosarcoma cells through a skull screw into the cerebrum in the right frontal region. Twelve-day-old tumors were inoculated through the screw with recombinant adenoviral vectors under isoflurane anaesthesia: control rats with Ad5/RSV/GL2 (carrying the luciferase gene), and study rats with Ad5CMV-p53 (carrying the wtp53 gene). Brain tumors removed at specific times after transfection were measured, homogenized, and lysed and wtp53 expression determined by Western blot analysis. Four groups of nine rats were, subsequently, implanted with iodine-125 seeds 15 days post-tumor inoculation to give a minimum tumor dose of 40 or 60 Gy.We demonstrated transfer of wtp53 into rat 9L tumors in vivo using the Ad5CMV-p53 vector. The expression of wtp53 was demonstrated to be maximum between days 1 and 3 post-vector inoculation. Tumors expressing wtp53 were smaller than controls transfected with Ad5/RSV/GL2 but this difference was not statistically significant. Radiation made a significant difference to the survival of tumor-bearing rats. Moreover, wtp53 expression conferred a significant additional survival advantage.The expression of wtp53 significantly improves the survival of irradiated tumor-bearing rats in our model.
- Published
- 2000
19. [Simple renal cysts in children: treatment with ethyl alcohol injection into their lumen]
- Author
-
W, Perdzyński, M, Klewar, J, Rutka, Z, Stembrowicz, and B, Sakson
- Subjects
Male ,Treatment Outcome ,Adolescent ,Ethanol ,Child, Preschool ,Anti-Infective Agents, Local ,Humans ,Female ,Kidney Diseases, Cystic ,Ultrasonography, Doppler, Color ,Child ,Radionuclide Imaging ,Injections - Abstract
The authors assess the efficacy of treatment of simple renal cysts with 95.5% ethyl alcohol injected into their lumen.The diagnosis was confirmed by traditional US and color Doppler, urography, and renal scintigraphy. In four children with simple renal cysts ultrasound-guided puncture, aspiration of fluid and instillation of 95.5% of ethyl alcohol for 15-20 minutes were performed and a needle was withdrawn.In three children 3 weeks after the procedure diameter of cysts began to diminish and by the 5th week cysts were not detected in US. In the fourth child the cyst started to diminish 2 months after the procedure and disappeared after the next 3 months. There was no cyst recurrence after the procedure (average follow-up: 22 months).In 4 children treatment of simple renal cyst with 95.5% ethyl alcohol has proved safe and effective treatment.
- Published
- 2000
20. [A form of premorbid condition of urolithiasis and urinary stone composition in children with urolithiasis]
- Author
-
A, Jung, A, Kamińska, S, Olszewski, and J, Rutka
- Subjects
Male ,Adolescent ,Risk Factors ,Child, Preschool ,Humans ,Infant ,Female ,Urinary Calculi ,Child ,Severity of Illness Index - Abstract
In diagnosis, monitoring and prophylaxis of urolithiasis it is important to use simple, non-invasive tests. The aim of the study was to define the value of crystallizing ratios in urine in correlation with chemical stone composition in presumptive diagnosis and monitoring patients with urolithiasis. The study involved 102 children. An analysis of chemical stone composition was carried out in 62 cases. A correlation between values of crystallizing ratios in the urine, indicating the kind of preurolithiasis state and chemical stone composition has been found.
- Published
- 2000
21. [Changes of kidney parenchyma in children with nephrolithiasis after ESWL treatment in ultrasonography, power Doppler and thermovision monitoring]
- Author
-
J, Rutka, A, Jung, J, Zuber, and B, Kalicki
- Subjects
Male ,Kidney Calculi ,Time Factors ,Adolescent ,Thermography ,Child, Preschool ,Lithotripsy ,Humans ,Female ,Ultrasonography, Doppler ,Child ,Kidney - Abstract
The authors discuss the results ultrasonographic (USG), power Doppler (PD) and thermovision (TV) examination in monitoring changes of kidney parenchyma in 30 children with nephrolithiasis after ESWL treatment. To monitor possible effect of shock wave on the kidney parenchyma the USG, PD and TV examination were done before ESWL treatment as well as, 48 hours and 3 months following the treatment. Parts of kidney parenchyma localized on the way of shock wave to the stone were analysed. Echogenicity of kidney parenchyma was analysed by comparison of echo amplitude in subsequent USG examinations. Parenchymal blood flow by computer analyse was estimated. In TV examination the temperature distribution in the place of skin kidney projection was estimated. Changes in echogenicity of kidney parenchyma and impaired kidney parenchymal blood flow 48 hours after ESWL were found. In TV examination 48 hours after ESWL transient reduction in skin temperature was observed in the place of shock wave transmission. In 3 months after ESWL disturbances in the kidney parenchyma in USG, PD and TV were not observed.
- Published
- 2000
22. The risk of hearing loss in nongrowing, conservatively managed acoustic neuromas
- Author
-
P, Warrick, M, Bance, and J, Rutka
- Subjects
Adult ,Male ,Time Factors ,Hearing Loss, Sensorineural ,Neuroma, Acoustic ,Middle Aged ,Magnetic Resonance Imaging ,Severity of Illness Index ,Risk Factors ,Audiometry, Pure-Tone ,Humans ,Cranial Nerve Neoplasms ,Female ,Aged ,Follow-Up Studies ,Retrospective Studies - Abstract
To determine the risk of loss of useful hearing in the absence of tumor growth among patients undergoing conventional management of acoustic neuroma.Tertiary referral center.Retrospective case review.Ten patients (12 ears) were identified having a period of no tumor growth of at least 6 months (19.0+/-12.8 months), and for whom at least two audiograms were available in this period.None.Loss of useful hearing defined using 70% speech discrimination score (SDS) and 30 dB pure tone average (PTA) (70/30), or 50% SD and 50 dB PTA (50/50) criteria.Three of seven (43%) ears with useful hearing using the 70/30 rule and two of eight ears (25%) using the 50/50 rule lost this useful hearing.There is a significant risk of useful hearing loss with conservative management of nongrowing acoustic neuromas.
- Published
- 1999
23. Verotoxin induces apoptosis and the complete, rapid, long-term elimination of human astrocytoma xenografts in nude mice
- Author
-
S, Arab, J, Rutka, and C, Lingwood
- Subjects
Male ,Brain Neoplasms ,Cytotoxins ,Bacterial Toxins ,Transplantation, Heterologous ,Mice, Nude ,Antineoplastic Agents ,Apoptosis ,Astrocytoma ,Shiga Toxin 1 ,Mice ,Tumor Cells, Cultured ,Animals ,Humans ,Female ,Drug Screening Assays, Antitumor ,Glioblastoma - Abstract
Verotoxin 1 (VT1) is an E. coli elaborated subunit toxin active only against (tumor) cell lines that express the VT1 receptor, globotriaosyl ceramide-Gb3. Astrocytomas can be highly malignant brain tumors that remain refractory to clinical treatment. Some human astrocytoma cell lines are particularly sensitive to VT1 in vitro. To address whether this represents a feasible approach to the elimination of these tumors in man, human astrocytoma tumor xenografts in nude mice were treated with verotoxin. Following a single low-dose intratumoral injection of VT1, complete regression of a 1-cm-diameter tumor within 10 days was observed in all treated animals, without reoccurrence (up to 60 days). Apoptosis was demonstrated in both tumor and vascular cells within the treated xenograft. Verotoxin binding to tumor cells and blood vessels in sections of primary glioblastoma multiforme was found.
- Published
- 1999
24. No therapy: use, abuse, efficacy, and morbidity--the European versus the Third-World experience
- Author
-
J, Rutka and S, Lekagul
- Subjects
Otitis Media ,Child, Preschool ,Acute Disease ,Chronic Disease ,Humans ,Infant ,Drug Resistance, Microbial ,Child ,Global Health ,Developing Countries - Abstract
Historical controls documented a marked reduction in complications from acute otitis media (AOM) and chronic suppurative otitis media (CSOM) with the introduction of antibiotic therapy in the period 1930 to 1950s amongst other changes that occurred in North American and Western European society. Today, the natural history of spontaneous remission in AOM in over 80% of children within 24 hours of presentation questions the raison d'etre for the routine prescription of antibiotics for what may essentially be a self-limiting condition. Metaanalyses of numerous antibiotic versus placebo trials in the treatment of AOM have demonstrated little difference in clinical outcome, as have treatment stratagems where antibiotics have been initially withheld. More judicious use of antibiotic therapy in AOM appears to have been associated with a decline in antimicrobial resistance in countries such as the Netherlands and Iceland. It is difficult to know, however, whether the direct savings from decreased antibiotic use will ultimately lead to an actual decrease in the other direct and indirect costs associated with AOM. Unfortunately, children in the third world have not experienced a corresponding decline in ear disease. Significant loss of disability-adjusted life years (DALYs) continues to occur from otitis media. Withholding antibiotic therapy in the treatment of AOM would more than likely impose greater morbidity and mortality on an already disadvantaged population. Nevertheless, the experience of the Thai Rural Ear Nose and Throat Foundation has been seminal in documenting and affecting change in both the morbidity and mortality patterns of AOM and CSOM during Thailand's transition toward developed nation status. This article analyzes these issues and provides a review of the literature available.
- Published
- 1998
25. Application of liquid crystalline thermographic foils in diagnostics of prick skin tests for children
- Author
-
Jozef Zmija, Krzysztof Czupryński, J. Rutka, Stanislaw J. Klosowicz, Anna Jung, B. Kalicki, and Janusz Zuber
- Subjects
Materials science ,Diagnostic methods ,Liquid crystalline ,Liquid crystal thermography ,Computer processing ,Thermography ,Skin surface ,Human skin ,Prick skin tests ,Biomedical engineering - Abstract
Liquid-crystal thermography has been applied to estimate results of skin prick tests for children. Over 30 childrenchosen for tests due to allergy or other diseases have been examined. A new kind of thermographic foils containgchiral nematics has been applied.Keywords: liquid crystal thermography, prick skin test, chiral nematics, allergy diagnosis, tuberculin tests. 1. INTRODUCTION Liquid - crystal contact thermography (LCT) as fast, non- invasive and efficient method for visualisation oftemperature fields on the skin surface is especially useful diagnostics method for children.In many cases so called prick skin tests are used as diagnostic method, e.g. in case of allergy or tuberculindiagnostics. The visualisation of the area of elevated temperature, which is result of organism reaction for a test, ismuch more objective than simple visual observation by a doctor. It is especially true for skin changed by diseases orcoloured. Moreover, in certain cases the temperature reaction is not followed by the change of skin features, e.g.blister or flame.LCT is cheaper and more user-friendly than thermovision, although the latter method is more objective andallows for direct computer processing of obtained colour images.In our initial studies the temperature background of human skin, temperature ranges of LC mixtures andcorrelation between temperature and inflammation features of prick test area have been established'2. In the presentcontribution the optimisation ofLCT is presented, including as physical as medical aspects. The results obtained by adeveloped routine method are also discussed.
- Published
- 1998
26. Rescued from the sands of time: interesting otologic and rhinologic findings in two ancient Egyptian mummies from the Royal Ontario Museum
- Author
-
M, Yardley and J, Rutka
- Subjects
Embalming ,Egypt, Ancient ,Paranasal Sinuses ,Skull ,Humans ,Temporal Bone ,Mummies ,Nasal Cavity ,Tomography, X-Ray Computed ,History, Ancient - Abstract
Two mummified specimens from the Royal Ontario Museum both approximately 3500 years old were recently examined in the Ear Pathology Research Laboratory (EPRL) of the University of Toronto. High-resolution computed tomography (CT) scanning of the ancient Egyptian mummified heads was undertaken with special reference to the nasal cavities, paranasal sinuses, anterior cranial fossae, and temporal bones. The elaborate ritual for the dead that was required to prepare for the after life and our knowledge concerning the status of ear and nasal pathology in ancient Egypt is reviewed.As a result of this preliminary study, we believe we may have discovered a hitherto unrecognized step in the formal process of mummificiation.
- Published
- 1998
27. Prevalence of head-shaking nystagmus in patients according to their diagnostic classification in a dizziness unit
- Author
-
S, Asawavichianginda, M, Fujimoto, M, Mai, and J, Rutka
- Subjects
Adult ,Male ,Adolescent ,Tympanic Membrane Perforation ,Electronystagmography ,Middle Aged ,Dizziness ,Nystagmus, Pathologic ,Vestibular Diseases ,Caloric Tests ,Humans ,Female ,Prospective Studies ,Child ,Aged - Abstract
In a previous publication, the authors documented the prevalence and characteristics of head-shaking nystagmus (HSN) in over 1300 consecutive dizzy patients during formal electronystagmography (ENG) at the combined Otologic Function Unit (OFU) of the Toronto and Mount Sinai Hospitals. This companion study was done to prospectively analyze a subgroup of 300 patients with known clinical diagnoses belonging to the senior author (J.R.).The prevalence of HSN in this series of patients with a known diagnosis is prospectively compared to the presence of HSN in a series of normal controls.Results indicate that HSN is seen significantly (p.05) in those patients with peripheral vestibular dysfunction and that the more globally the peripheral vestibular disorder involves end-organ (i.e., Meniere's) or primary afferent-neuron function (i.e., vestibular neuronitis), the more likely HSN will be present.We further comment on the usefulness of the head-shake test and its clinical relevance in the bedside examination of the dizzy patient.
- Published
- 1997
28. Results of labyrinthectomy in the treatment of Menière's disease and delayed endolymphatic hydrops
- Author
-
A K, Yazdi and J, Rutka
- Subjects
Adult ,Male ,Middle Aged ,Postoperative Complications ,Treatment Outcome ,Ear, Inner ,Surveys and Questionnaires ,Vertigo ,Humans ,Endolymphatic Hydrops ,Female ,Meniere Disease ,Aged ,Retrospective Studies - Abstract
Transmastoid total osseous labyrinthectomy for incapacitating unilateral Meniére's disease and the related clinical phenomenon of delayed endolymphatic hydrops (DEH) is a generally accepted treatment modality when hearing preservation is not an issue. Over the past 8 years, 25 patients (13 Meniére's and 12 DEH) underwent labyrinthectomy by the senior author (J.R.) at the Toronto Hospital. This retrospective study compares and contrasts these two clinical groups preoperatively and subsequently analyzes the results of labyrinthectomy. The patients' own responses to a specially designed questionnaire provided valuable insight into the efficacy of labyrinthectomy and into some of the long-term problems they experienced following surgery.
- Published
- 1996
29. Pediatric malignant glioma with tubuloreticular inclusions and MYCN amplification. Report of a case with immunohistochemical, ultrastructural, flow cytometric, karyotypic, and Southern blot analysis
- Author
-
V, Jay, J, Rutka, L E, Becker, and J, Squire
- Subjects
Cell Nucleus ,Chromosome Aberrations ,Inclusion Bodies ,Male ,Cytoplasm ,Brain Neoplasms ,Genes, myc ,Mitosis ,Chromosome Disorders ,Glioma ,Flow Cytometry ,Immunohistochemistry ,Frontal Lobe ,Mitochondria ,Gene Expression Regulation, Neoplastic ,Blotting, Southern ,Child, Preschool ,Karyotyping ,Glial Fibrillary Acidic Protein ,Humans ,Vimentin ,Endothelium, Vascular ,Chromosome Deletion - Abstract
The authors described unusual pathologic features in a left frontal lobe malignant glioma in a 31/2-year-old boy. The pathology was similar in the initial excision and two subsequent recurrences at 9 and 11 months and at autopsy, when extensive subarachnoid spread was noted.The tumor was studied by conventional histology, immunohistochemistry, flow cytometry, transmission electron microscopy (TEM), immune electron microscopy (IEM), and cytogenetic and Southern blot analysis.The tumor revealed two different histologic patterns. One component showed large cells with eosinophilic cytoplasm, vesicular nuclei with prominent nucleoli, eosinophilic perinuclear inclusions, and immunoreactivity for glial fibrillary acidic protein (GFAP) and vimentin. The other component consisted of undifferentiated cells with hyperchromatic nuclei and scanty cytoplasm. By TEM, the perinuclear aggregates were composed of tubuloreticular inclusions, which were also observed in endothelial cells within the tumor vasculature. By IEM, the intermediate filaments in the tumor cell cytoplasm were decorated with GFAP. Flow cytometric results revealed a marked increase in the S-phase (48%), whereas cytogenetic analysis of short-term cultures showed an abnormal karyotype containing marker chromosomes and double minutes. In the second resection, additional karyotypic abnormalities were noted, including 1p- and several additional markers. The first and second resections showed MYCN amplification by Southern Blot analysis in the 60- to 80-fold range.This tumor presents unique histologic, ultrastructural, and cytogenetic findings as well as MYCN amplification that is notable for a pediatric malignant glioma. Tubuloreticular inclusions were a prominent feature in this tumor, which again is unique for a glioma.
- Published
- 1994
30. Tumors of the skull base: outcome and survival analysis of 77 cases
- Author
-
J Rutka, Jeremy L. Freeman, Fred Gentili, Patrick J. Gullane, Jonathan C. Irish, Dale Brown, and J B Boyd
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Skull Neoplasms ,Facial Bones ,Surgical Flaps ,Temporal bone ,medicine ,Carcinoma ,Humans ,Basal cell carcinoma ,Survival rate ,Aged ,Neoplasm Staging ,Retrospective Studies ,Aged, 80 and over ,Epithelioma ,business.industry ,Postoperative complication ,Middle Aged ,medicine.disease ,Combined Modality Therapy ,Survival Analysis ,Surgery ,Osteotomy ,Survival Rate ,Skull ,medicine.anatomical_structure ,Treatment Outcome ,Otorhinolaryngology ,Carcinoma, Basal Cell ,Carcinoma, Squamous Cell ,Lymph Node Excision ,Histopathology ,Female ,Dura Mater ,business ,Craniotomy ,Follow-Up Studies - Abstract
We reviewed our experience with combined approaches to lesions that transcend the bones of the skull base. Seventy-seven skull base procedures were performed on 73 patients during a 10-year period from 1982 to 1992. There were 34 patients (44%) with region lesions (anterior), seven patients (9%) with region II lesions (anterior-lateral), 25 patients (32%) with region III lesions (lateral-posterior), and 11 patients (14%) with lesions that invaded more than one anatomic site. The histopathology in this series was quite variable, with 22 patients (29%) having squamous cell carcinoma and eight patients (10%) having basal cell carcinoma. Forty-one patients had surgery by an anterior approach and 38 patients had lateral approaches, with 18 undergoing an infratemporal approach and 29 undergoing temporal bone resections. Overall, 44% of the patients had a postoperative complication. Survival of this heterogeneous group of patients is 79% at 2 years and 71% at 4 years, with those patients with region II disease having a statistically significant poorer prognosis with no survivors at 4 years.
- Published
- 1994
31. A study into the phenomenon of head-shaking nystagmus: its presence in a dizzy population
- Author
-
M, Fujimoto, J, Rutka, and M, Mai
- Subjects
Adult ,Aged, 80 and over ,Male ,Chi-Square Distribution ,Adolescent ,Incidence ,Movement ,Electronystagmography ,Middle Aged ,Dizziness ,Nystagmus, Pathologic ,Nystagmus, Physiologic ,Humans ,Female ,Child ,Aged - Abstract
In this paper we have prospectively analyzed results from approximately 1,500 patients who underwent a head-shaking test during routine electronystagmography (ENG). The incidence of head-shaking nystagmus (HSN) in a dizzy population was relatively high (31.7%) when compared to other so-called abnormalities in the routine ENG test battery. Its presence was also similar in both active vs. passive head-shake tests. When present, different types of HSN were identified (monophasic (76.8%), biphasic (22.7%) and triphasic (0.5%)). In some cases, reversals of the expected "normal" pattern occurred. A high correlation was found to exist between a positive head-shake test and the presence of spontaneous nystagmus, positional nystagmus and caloric test abnormalities.
- Published
- 1993
32. Deafness, dysphagia and a middle ear mass in a patient with neurofibromatosis type 2
- Author
-
D, Tees, N, Lofchy, and J, Rutka
- Subjects
Adult ,Neurofibromatosis 2 ,Brain Neoplasms ,Optic Nerve Diseases ,Humans ,Cranial Nerve Neoplasms ,Female ,Pharyngeal Neoplasms ,Glioma ,Deafness ,Deglutition Disorders ,Tomography, X-Ray Computed - Published
- 1992
33. Translabyrinthine identification of the cochlear aqueduct: a helpful landmark during inferomedial temporal bone dissection
- Author
-
J, Rutka and J, Nedzelski
- Subjects
Dissection ,Ear, Inner ,Humans ,Temporal Bone ,Jugular Veins ,Endolymphatic Duct ,Cochlear Aqueduct ,Glossopharyngeal Nerve - Abstract
Translabyrinthine identification of the cochlear aqueduct (CA) in 20 cadaveric temporal bones allowed anatomical measurements to be made between its horizontal portion and other inferomedial structures. Its role as a landmark during temporal bone surgery is discussed.
- Published
- 1991
34. Acoustic neuroma presenting as a middle ear mass
- Author
-
P J, Stoney, J, Rutka, E, Dolan, and M, Hawke
- Subjects
Labyrinth Diseases ,Ear, Middle ,Humans ,Female ,Neuroma, Acoustic ,Middle Aged ,Ear Neoplasms - Published
- 1991
35. Neurosurgical/ENT Management of Paranasal Sinus Lesions Extending Through the Skull Base
- Author
-
J. Rutka, E. J. Dolan, P. Gullane, and F. Gentili
- Subjects
medicine.medical_specialty ,Calvarial defect ,business.industry ,General surgery ,Infratemporal fossa ,En bloc resection ,Anatomy ,Resection ,Skull ,medicine.anatomical_structure ,medicine ,General hospital ,business ,Sinus (anatomy) ,Anterior skull base - Abstract
The present work illustrates our experience at Toronto General Hospital with extensive anterior skull base lesions. This involves an interdisciplinary approach combining neurosurgical and otolaryngological expertise to manage neoplasms in this complex area, especially for malignant lesions, where we believe an en bloc resection of the tumor is necessary. This interdisciplinary approach is most helpful in enabling single-stage resection and reconstruction of the skull base with minimal morbidity and mortality.
- Published
- 1991
36. Speculation into the etiologic role of viruses in the development of Bell's palsy and disorders of inner ear dysfunction: a case history and review of the literature
- Author
-
M, Bance and J, Rutka
- Subjects
Adult ,Vestibular Diseases ,Facial Paralysis ,Humans ,Female ,Herpes Zoster ,Meniere Disease ,Follow-Up Studies - Abstract
It has long been postulated that Bell's palsy and a number of inner ear disorders may have as their basis a common underlying viral etiology. The change from one recognizable inner ear disorder into another is not unusual in the same patient and has been recognized by neurotologists. The case history of a patient who initially presented with an idiopathic facial palsy that years later developed into a spectrum of vestibular dysfunction associated with the clinical stigmata of herpes zoster is discussed. Although difficult to prove, support for this continuum theory is reviewed, taking into account known viral involvement in other cranial nerves and various histopathologic findings from disorders involving the inner ear and facial nerve.
- Published
- 1990
37. Identifying novel p14ARF binding partners
- Author
-
S. Mondal, S. Ivanchuk, and J. Rutka
- Subjects
Cancer Research ,Oncology ,Computer science ,Computational biology - Published
- 2001
38. Spatial correlation between motor Functional MRI and intraoperative brain mapping in brain tumors: a double blind, prospective study
- Author
-
Jean-Philippe Ranjeva, J Rutka, J Sabatier, M. Tremoulet, Kader Boulanouar, Franck-Emmanuel Roux, C. Manelfe, and Isabelle Berry
- Subjects
Double blind ,Spatial correlation ,medicine.medical_specialty ,Neurology ,business.industry ,Cognitive Neuroscience ,medicine ,Radiology ,Prospective cohort study ,business ,Brain mapping - Published
- 1998
39. First records of scale deformities in seven freshwater fish species (Actinopterygii: Percidae and Cyprinidae) collected from three ponds in the Czech Republic
- Author
-
J. Rutkayová, L. Jawad, J. Nebesářová, K. Beneš, E. Petrášková, and J. Näslund
- Subjects
fish ,scale abnormality ,adverse environment ,Cypr ,Aquaculture. Fisheries. Angling ,SH1-691 - Abstract
Background. A wide range of morphological anomalies, including abnormalities in scale shape and structure, have been described from a large number of fish species worldwide. Quite often, such reports linked the observed abnormalities to the quality of aquatic environment. The presently reported study was initiated to explore and categorize the abnormalities found in the scales of seven freshwater fish species of Czech Republic: Ctenopharyngodon idella (Valenciennes, 1844); Gymnocephalus cernua (Linnaeus, 1758); Hypophthalmichthys molitrix (Valenciennes, 1844); Hypophthalmichthys nobilis (Richardson, 1845); Leuciscus idus (Linnaeus, 1758); Perca fluviatilis Linnaeus, 1758; and Sander lucioperca (Linnaeus, 1758). The observed abnormalities are discussed in the context of contaminated aquatic environments with the intention to understand the aetiology of the abnormalities. Materials and methods. Samples were collected at 3 sites (ponds) in the Czech Republic. In total, 10 200 scales were collected, cleared in 1% potassium hydroxide, and observed under a light microscope. Four variables were measured for each scale: anterior–posterior length (major axis, MAA), dorsal–ventral length (minor axis, MIA), diameter of the focus in the centre of the scale, number of radial lines (radii) starting from near focus, and the ratio of major to minor axes were calculated as a measure of scale shape. Results. The anomalous scales, 63 in total, were collected from ten different body regions in seven species studied. They exhibited different shapes and sizes: 30 scales showed severe anomalies and 33 only slight ones. Based on the MAA : MIA ratio, the majority of the scales examined had a narrow to rectangular or broad to squarish shape. Elongated scales were only obtained from H. molitrix, H. nobilis, and C. idella. There were one square-shaped and 8 rectangular-shaped scales in G. cernua, 3 and 6 in P. fluviatilis, and 2 and 1 in S. lucioperca. Conclusion. The presently reported cases of fish scale abnormalities should direct the future work on the relations between the state of the environment and fish health. Another interesting question to answer would be to determine whether or not the removal of abnormal scales would lead to replacement by either normal or abnormal scales.
- Published
- 2016
- Full Text
- View/download PDF
40. Response to low dose temozolomide in radiation induced gliomatosis cerebri.
- Author
-
D. Hargrave, E. Bouffet, J. Gammon, L. Becker, and J. Rutka
- Published
- 2003
- Full Text
- View/download PDF
41. Computed tomographic analysis of the intratemporal facial nerve and facial nerve neuromas
- Author
-
L, Shankar, M, Hawke, R N, Leekam, and J, Rutka
- Subjects
Adult ,Male ,Facial Paralysis ,Ear, Middle ,Temporal Bone ,Mastoid ,Facial Nerve ,Neuroma ,Ear, Inner ,Humans ,Cranial Nerve Neoplasms ,Female ,Facial Nerve Diseases ,Tomography, X-Ray Computed - Abstract
High-resolution computed tomography (HRCT) has replaced multidirectional tomography in the detailed analysis of the temporal bone because of its excellent resolution of fine bony detail. Small soft-tissue masses not discernible on plain tomograms are easily seen using HRCT. Unsuspected early disease which has not caused recognizable bone erosion in also demonstrable by HRCT. Last but not least, the amount of radiation received by a patient as a result of HRCT is considerably less. We illustrate the normal course of the facial nerve through the temporal bone, its anatomical relationship to various adjacent structures, and the numerous branches given off during its course through the temporal bone. The clinical features of facial nerve neuromas (schwannomas) depend on their location and include facial nerve weakness or paralysis, otalgia or facial pain, hearing loss or imbalance, and loss of taste sensation. HRCT allows the identification of a soft-tissue mass along the course of the facial nerve, with its bony canal usually enlarged by the mass. Pressure erosion of the underlying bone is often noted and erosion of the ossicles may be demonstrated in the case of middle ear involvement. The importance of both clinical and radiological correlation cannot be overemphasized in the discovery of these tumors.
- Published
- 1989
42. Laryngocele: a case report and review
- Author
-
J, Rutka and D, Birt
- Subjects
Laryngeal Diseases ,Male ,Hoarseness ,Humans ,Middle Aged ,Deglutition Disorders ,Tomography, X-Ray Computed ,Laryngeal Neoplasms - Abstract
A 60 year old man had a symptomless mass in the neck for two years. Over two weeks he developed hoarseness and dysphagia and successfully underwent excision of a combined internal and external laryngocele. There is some disagreement in the literature as to when an enlarged saccule is a laryngocele and also as to whether laryngoceles result from chronic straining such as playing a wind instrument. Laryngeal carcinoma occasionally occurs in association with a clinical laryngocele. When sought for in laryngectomy specimens the incidence of laryngocele in patients with laryngeal carcinoma has been recorded at 18%.
- Published
- 1983
43. Preoperative Gelfoam embolization of supratentorial meningiomas
- Author
-
J, Rutka, P J, Muller, and M, Chui
- Subjects
Adult ,Male ,Carcinoma, Transitional Cell ,Middle Aged ,Embolization, Therapeutic ,Gelatin Sponge, Absorbable ,Preoperative Care ,Meningeal Neoplasms ,Humans ,Female ,Occipital Lobe ,Meningioma ,Aged ,Cerebral Hemorrhage - Abstract
Intracranial meningiomas are often highly vascular and a successful outcome depends upon surgical resection. Preoperative embolization of supratentorial meningiomas, which have a major blood supply from the external carotid artery, has been advocated to reduce intraoperative bleeding and thus facilitate surgical extirpation. The authors carried out transfemoral, Gelfoam embolization preoperatively in eight patients with supratentorial meningiomas. In seven of the cases, post-embolization, contrast-enhanced, computerized tomography was carried out. Areas of low-density tumour necrosis were identified in five. In three of the eight patients, post-embolization angiography demonstrated elimination of the tumour blush and in the other five, the blush was reduced in intensity. Histologic evidence of tumour embolization was identified in each case to a varying degree. Preoperative embolization resulted in an identifiable radiologic change in the majority of these tumours, but the authors could not determine, in this small series, whether intraoperative bleeding was reduced.
- Published
- 1985
44. Cavernous hemangioma of the incus (an incidental finding)
- Author
-
J, Rutka and M, Hawke
- Subjects
Adult ,Diagnosis, Differential ,Male ,Hemangioma, Cavernous ,Incus ,Neoplasms, Vascular Tissue ,Humans ,Ear Ossicles - Abstract
The incidental discovery of a cavernous hemangioma in an apparently normal incus found during pathological examination is reported. The incus had been removed during the course of a total osseous labyrinthectomy for delayed endolymphatic hydrops (DEH), and this unexpected finding noted. Although rare, hemangiomatous involvement of the temporal bone does occur and its manifestations are discussed. To date there have been no other reports of a hemangioma involving the incus solely.
- Published
- 1989
45. Toxic and drug-induced disorders in otolaryngology
- Author
-
J, Rutka and P W, Alberti
- Subjects
Hearing Loss, Sensorineural ,Salivary Gland Diseases ,Deafness ,Dermatitis, Contact ,Otitis Externa ,Thyroid Diseases ,Anti-Bacterial Agents ,Drug Hypersensitivity ,Laryngeal Diseases ,Nasal Decongestants ,Otorhinolaryngologic Diseases ,Cocaine ,Humans ,Vestibule, Labyrinth ,Postural Balance ,Meniere Disease ,Rhinitis - Abstract
Toxic and drug-induced disorders can be identified with alarming frequency. Otolaryngologists in the past were acutely aware of the ototoxic properties of certain medications but, with today's increasing armamentarium, new problems arise that may have an iatrogenic cause.
- Published
- 1984
46. Multiple myeloma involving the cricoid cartilage
- Author
-
J, Rutka, A M, Noyek, J S, Chapnik, D, Amato, N, Couter, and M I, Steinhardt
- Subjects
Male ,Radiography ,Laryngeal Cartilages ,Humans ,Multiple Myeloma ,Cartilage Diseases ,Aged ,Cricoid Cartilage - Abstract
This presents a case report of a patient with multiple myeloma who developed such a lesion in the cricoid--a circumstance which has not previously been recorded.
- Published
- 1985
47. Intracranial hypoglossal neurinoma
- Author
-
J Rutka, P Gullane, and E. J. Dolan
- Subjects
medicine.medical_specialty ,business.industry ,medicine ,Surgery ,Neurology (clinical) ,Radiology ,business - Published
- 1989
48. Combination treatment with histone deacetylase and carbonic anhydrase 9 inhibitors shows therapeutic potential in experimental diffuse intrinsic pontine glioma.
- Author
-
Fujita N, Bondoc A, Simoes S, Ishida J, Taccone MS, Luck A, Srikanthan D, Siddaway R, Levine A, Sabha N, Krumholtz S, Kondo A, Arai H, Smith C, McDonald P, Hawkins C, Dedhar S, and Rutka J
- Subjects
- Humans, Carbonic Anhydrase Inhibitors pharmacology, Carbonic Anhydrase Inhibitors therapeutic use, Cell Line, Tumor, Cell Movement drug effects, Carbonic Anhydrase IX antagonists & inhibitors, Carbonic Anhydrase IX genetics, Drug Synergism, Animals, Sulfonamides, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Antineoplastic Combined Chemotherapy Protocols pharmacology, Phenylurea Compounds, Histone Deacetylase Inhibitors pharmacology, Brain Stem Neoplasms drug therapy, Brain Stem Neoplasms pathology, Brain Stem Neoplasms genetics, Diffuse Intrinsic Pontine Glioma drug therapy, Diffuse Intrinsic Pontine Glioma genetics, Diffuse Intrinsic Pontine Glioma pathology, Cell Proliferation drug effects
- Abstract
Diffuse intrinsic pontine glioma (DIPG) remains a significant therapeutic challenge due to the lack of effective and safe treatment options. This study explores the potential of combining histone deacetylase (HDAC) and carbonic anhydrase 9 (CA9) inhibitors in treating DIPG. Analysis of RNA sequencing data and tumor tissue from patient samples for the expression of the carbonic anhydrase family and hypoxia signaling pathway activity revealed clinical relevance for targeting CA9 in DIPG. A synergy screen was conducted using CA9 inhibitor SLC-0111 and HDAC inhibitors panobinostat, vorinostat, entinostat, and pyroxamide. The combination of SLC-0111 and pyroxamide demonstrated the highest synergy and was selected for further analysis. Combining SLC-0111 and pyroxamide effectively inhibited DIPG cell proliferation, reduced cell migration and invasion potential, and enhanced histone acetylation, leading to decreased cell population in S Phase. Additionally, the combination therapy induced a greater reduction in intracellular pH than either agent alone. Data from this study suggest that the combination of SLC-0111 and pyroxamide holds promise for treating experimental DIPG, and further investigation of this combination therapy in preclinical models is warranted to evaluate its potential as a viable treatment for DIPG., (© 2024. The Author(s), under exclusive licence to The Japan Society of Brain Tumor Pathology.)
- Published
- 2024
- Full Text
- View/download PDF
49. Structural connectivity changes in unilateral hearing loss.
- Author
-
Tsai P, Latypov TH, Hung PS, Halawani A, Srisaikaew P, Walker MR, Zhang AB, Wang W, Hassannia F, Barake R, Gordon KA, Ibrahim GM, Rutka J, and Hodaie M
- Subjects
- Humans, Female, Male, Middle Aged, Adult, Brain diagnostic imaging, Brain physiopathology, Brain pathology, Neuroma, Acoustic diagnostic imaging, Neuroma, Acoustic physiopathology, Neuroma, Acoustic pathology, Neural Pathways physiopathology, Neural Pathways diagnostic imaging, Magnetic Resonance Imaging methods, Aged, Diffusion Tensor Imaging, Functional Laterality physiology, Nerve Net diagnostic imaging, Nerve Net physiopathology, Nerve Net pathology, Hearing Loss, Unilateral diagnostic imaging, Hearing Loss, Unilateral physiopathology, Connectome
- Abstract
Network connectivity, as mapped by the whole brain connectome, plays a crucial role in regulating auditory function. Auditory deprivation such as unilateral hearing loss might alter structural network connectivity; however, these potential alterations are poorly understood. Thirty-seven acoustic neuroma patients with unilateral hearing loss (19 left-sided and 18 right-sided) and 19 healthy controls underwent diffusion-weighted and T1-weighted imaging to assess edge strength, node strength, and global efficiency of the structural connectome. Edge strength was estimated by pair-wise normalized streamline density from tractography and connectomics. Node strength and global efficiency were calculated through graph theory analysis of the connectome. Pure-tone audiometry and word recognition scores were used to correlate the degree and duration of unilateral hearing loss with node strength and global efficiency. We demonstrate significantly stronger edge strength and node strength through the visual network, weaker edge strength and node strength in the somatomotor network, and stronger global efficiency in the unilateral hearing loss patients. No discernible correlations were observed between the degree and duration of unilateral hearing loss and the measures of node strength or global efficiency. These findings contribute to our understanding of the role of structural connectivity in hearing by facilitating visual network upregulation and somatomotor network downregulation after unilateral hearing loss., (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2024
- Full Text
- View/download PDF
50. Current immunotherapeutic approaches to diffuse intrinsic pontine glioma.
- Author
-
Lin C, Smith C, and Rutka J
- Abstract
Diffuse intrinsic pontine glioma (DIPG) is an aggressive brain tumour that occurs in the pons of the brainstem and accounts for over 80% of all brainstem gliomas. The median age at diagnosis is 6-7 years old, with less than 10% overall survival 2 years after diagnosis and less than 1% after 5 years. DIPGs are surgically inaccessible, and radiation therapy provides only transient benefit, with death ensuing from relentless local tumour infiltration. DIPGs are now the leading cause of brain tumour deaths in children, with a societal cancer burden in years of life lost (YLL) of more than 67 per individual, versus approximately 14 and 16 YLL for lung and breast cancer respectively. More than 95 clinical drug trials have been conducted on children with DIPGs, and all have failed to improve survival. No single or combination chemotherapeutic strategy has been successful to date because of our inability to identify targeted drugs for this disease and to deliver these drugs across an intact blood-brain barrier (BBB). Accordingly, there has been an increased focus on immunotherapy research in DIPG, with explorations into treatments such as chimeric antigen receptor T (CAR-T) cells, immune checkpoint blockades, cancer vaccines, and autologous cell transfer therapy. Here, we review the most recent advances in identifying genetic factors influencing the development of immunotherapy for DIPG. Additionally, we explore emerging technologies such as Magnetic Resonance-guided Focused Ultrasound (MRgFUS) in potential combinatorial approaches to treat DIPG., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Lin, Smith and Rutka.)
- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.