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A quasi-experimental investigation assessed the impact of multiple factors, including financial aid and proactive advising, on retention of undergraduate students at a small, private university that primarily serves online learners. In-house proactive advising over three academic years was positively associated with increased retention semester-to-semester and fall-to-fall. In addition, students who received Pell Grants plus at least one other form of financial aid, completed math remediation, and transferred 30 or more credit hours persisted at higher rates semester-to-semester. Individuals identifying with historically underrepresented groups tended to persist at rates lower than their White peers’ semester-to-semester retention. These findings support the efficacy of proactive advising and financial aid, even with a population that exhibits lower retention for persons from historically underrepresented groups. Findings also suggest that students who transfer more than two full-time semesters of credit have a strong motivation to complete their course of study.

Zusammenfassung. Fragestellung: Kinder- und jugendpsychiatrische Notfälle während der SARS-CoV2-19-Pandemie werden kontrovers diskutiert. In dieser Studie wird an der KJPPP Tübingen untersucht, inwiefern sich das Notfallaufkommen in der zweiten Welle im Vorjahresvergleich verändert hat. Dabei werden die Anzahl der Notfälle, die Altersstruktur sowie die Diagnosen der Essstörungen und Zwangsstörungen ausgewertet. Methodik: Daten zu allen an der KJPPP Tübingen bestehenden Notfallkontakten (Telefonate, ambulante Vorstellungen, Notaufnahmen) wurden für die Zeiträume 10/2019–01/2020 sowie 10/2020–01/2021 (zweite Welle) untersucht. Ergebnisse: Das Notfallaufkommen war im zweiten Zeitraum mit 319 Vorstellungen um 29.7 %, die reine Patient_innenenanzahl mit 172 Patient_innen um 10.3 % höher als im Vorjahr. Stationäre Notaufnahmen sind um 27.8 % gestiegen. Die Patient_innenzahl der stationären Notaufnahmen war 27.9 % höher. Das Patient_innenklientel war im zweiten Zeitraum mit durchschnittlich 14.8 Jahren etwas älter (erster Zeitraum: 14.2 Jahre). Das Notfallaufkommen der jüngsten Patient_innen (≤ 12.99 Jahre) war im zweiten Zeitraum geringer. Essstörungsdiagnosen finden sich im zweiten, Zwangserkrankungen hingegen im ersten Zeitraum häufiger. Schlussfolgerungen: Eine knapp 30 %-ige Steigerung des Notfallaufkommens zum Zeitpunkt der zweiten Welle der SARS-CoV2-19-Pandemie lässt sich in der KJPPP Tübingen feststellen. Insbesondere für Essstörungen zeigt sich ein deutlicher Anstieg. Um eine am regionalen Bedarf ausgerichtete Planung zu verwirklichen, sollte eine systematische Notfallerfassung an allen deutschen KJPPen realisiert werden.

Zusammenfassung. Fragestellung: Stationäre Notaufnahmen aufgrund einer psychischen Krise stellen einen erheblichen Anteil der stationären Aufnahmen kinder- und jugendpsychiatrischer Kliniken dar und haben in den vergangenen Jahren stark zugenommen. Die Studie untersucht, wie sich Charakteristika dieser Patient_innengruppe einer universitären Versorgungsklinik über zwei Jahrzehnte hinweg verändert haben. Methodik: Es erfolgte eine retrospektive Auswertung der Notaufnahmen der Jahrgänge 1996, 2002, 2008 und 2014 der KJPPP Tübingen bezüglich soziodemografischer Daten, psychosozialer Umstände und Diagnosen. Ergebnisse: Insgesamt wurden N = 403 Notaufnahmen ausgewertet. Es zeigte sich eine Steigerung von Notaufnahmen im genannten Zeitraum von 405 %. Bezüglich der psychosozialen Umstände ergab sich eine Zunahme von Familiensituationen mit getrennten Eltern. Des Weiteren war bei den Patient_innen eine deutliche Zunahme von Mehrfachdiagnosen festzustellen. Schlussfolgerungen: Über den Zeitraum 1996 bis 2014 ist ein erheblicher Anstieg von Notaufnahmen zu verzeichnen. Des Weiteren bestehen Hinweise auf ungünstigere psychosoziale Rahmenbedingungen und komplexere Erkrankungssituationen in späteren Jahren. Die Ergebnisse unterstreichen den Handlungsbedarf hinsichtlich der klinischen Versorgung von Kindern und Jugendlichen in akuten psychischen Krisen und deren Prävention, aber auch einer breiten gesellschaftlichen Diskussion zur Verbesserung der psychischen Gesundheit in der Entwicklung. Es besteht dringender Bedarf an prospektiven Studien zur differenzierten Betrachtung der Faktoren, die zum Anstieg von Notaufnahmen von Kindern und Jugendlichen führen.

Corticotropin-releasing factor (CRF) is essential for coordinating endocrine and neural responses to stress, frequently facilitated by vasopressin (AVP). Previous work has linked CRF hypersecretion, binding site changes, and dysfunctional serotonergic transmission with anxiety and affective disorders, including clinical depression. Crucially, CRF can alter serotonergic activity. In the dorsal raphé nucleus and serotonin (5-HT) terminal regions, CRF effects can be stimulatory or inhibitory, depending on the dose, site, and receptor type activated. Prior stress alters CRF neurotransmission and CRF-mediated behaviors. Lateral, medial, and ventral subdivisions of the central nucleus of the amygdala (CeA) produce CRF and coordinate stress responsiveness. The purpose of these experiments was to determine the effect of intracerebroventricular (icv) administration of CRF and AVP on extracellular 5-HT as an index of 5-HT release in the CeA, using in vivo microdialysis in freely moving rats and high performance liquid chromatography (HPLC) analysis. We also examined the effect of prior stress (1 h restraint, 24 h prior) on CRF- and AVP-mediated release of 5-HT within the CeA. Our results show that icv CRF infusion in unstressed animals had no effect on 5-HT release in the CeA. Conversely, in rats with prior stress, CRF caused a profound dose-dependent decrease in 5-HT release within the CeA. This effect was long-lasting (240 min) and was mimicked by CRF plus AVP infusion without stress. Thus, prior stress and AVP functionally alter CRF-mediated neurotransmission and sensitize CRF-induced inhibition of 5-HT release, suggesting that this is a potential mechanism underlying stress-induced affective reactivity in humans.

We consider general prepare-and-measure scenarios in which Alice can transmit qubit states to Bob, who can perform general measurements in the form of positive operator-valued measures (POVMs). We show that the statistics obtained in any such quantum protocol can be simulated by the purely classical means of shared randomness and two bits of communication. Furthermore, we prove that two bits of communication is the minimal cost of a perfect classical simulation. In addition, we apply our methods to Bell scenarios, which extends the well-known Toner and Bacon protocol. In particular, two bits of communication are enough to simulate all quantum correlations associated to arbitrary local POVMs applied to any entangled two-qubit state., 4 pages main text, 10 pages appendix, matches published version

Zusammenfassung. Einleitung: Internetbezogene Storungen (IBS) bei Jugendlichen und jungen Erwachsenen sind eng mit Familienfaktoren verknupft. Dennoch beziehen wenige Forschungs- und Ubersichtsarbeiten die Familie mit ein. Methodik: Die vorliegende Arbeit gibt einen Uberblick zu Elternfaktoren, die bei der Entstehung, Aufrechterhaltung und Reduktion einer Symptomatik beteiligt sein konnen. Hierfur wurden N = 87 wissenschaftliche Arbeiten in die Literaturubersicht integriert. Ergebnisse: Klare Zusammenhange finden sich in der Literatur zwischen der Eltern-Kind-Beziehung und IBS bei Jugendlichen und jungen Erwachsenen. Die Qualitat der Eltern-Kind-Kommunikation erscheint ein vielversprechender Ansatz zu sein, um eine IBS-Symptomatik zu beeinflussen. Es gibt Hinweise, dass zumindest fur manche Familien die Forderung der gemeinsam verbrachten Zeit hilfreich sein konnte. In Bezug auf erzieherische Aspekte sollte zwischen verschiedenen Bereichen unterschieden werden. Elterliches Wissen und Kontrolle der Internetnutzung scheinen Schutzfaktoren zu sein, der Effekt von Regeln und Restriktionen ist jedoch ungeklart. Schlussfolgerungen: Um eine IBS-Symptomatik zu verandern, ist es sinnvoll, die Eltern-Kind-Beziehung zu verbessern. Die Wege dorthin sind jedoch kaum erforscht. Empfehlungen in Bezug auf Erziehungsstrategien (z. B. Regeln und Restriktionen) sollten sehr vorsichtig formuliert werden, da die Effekte noch unklar sind. Die Integration der Eltern in Pravention und Intervention wird von vielen Forscher_innen befurwortet, es gibt jedoch nur einzelne Studien, die Eltern im Rahmen von Interventionen berucksichtigen. Abstract. Objective: Internet-related disorders (IRD) in adolescents and young adults are closely linked to family factors. However, few research and review articles include the family. To this end, N = 87 scientific papers were integrated into the literature review. Method: The present work gives an overview of parental factors that can be involved in the development, maintenance, and reduction of symptoms. Results: The literature provides clear connections between the parent-child relationship and IRD in adolescents and young adults. The quality of parent-child communication appears to be a promising approach for influencing IRD symptoms. There are indications that, at least for some families, encouraging the time spent together could be helpful. Regarding educational aspects, a distinction should be made between different areas. Parental knowledge and control of internet use seem to be protective factors. The effect of rules and restrictions, however, is unclear. Conclusions: To change IRD symptoms, it makes sense to improve the parent-child relationship. However, the ways to achieve that have hardly been explored. Recommendations regarding parenting strategies (e. g., rules and restrictions) should be formulated very carefully, as the effects are still unclear. The integration of parents in prevention and intervention efforts is advocated by many researchers, but there only individual studies have considered parents in the context of interventions.

In autism spectrum disorders (ASD), social communication and stereotypical behaviour patterns affect all areas of life, and can result in a decrease of its quality. Previous research has shown promising results for the social skills of groups of children with ASD. Furthermore, a pilot study of the Tübingen Group Training for Autism Spectrum Disorders (TüTASS) has demonstrated that mindfulness-based elements achieve additional positive effects. To build on these findings, the TüTASS training was adapted and expanded. Indeed, the TüTASS currently includes 20 90-min appointments starting with the basic skills of emotions, body, and communication, which are then transferred to personal, family, peer, and school spheres. The appointments have a fixed, consistent structure and each includes a body awareness exercise. In this study, we evaluated the TÜTASS with 27 children with ASD. The results showed improvements in pre-post comparison in behaviours associated with autism, as well as in externalising and internalising behaviours as assessed by parent reports, participant self-reports, and independent raters in participating children. Furthermore, the perceived parent burden in relation to their children decreased, whereas the participants’ self-rated quality of life increased. Overall, both the participants and their parents rated the TüTASS very positively in rating sheets and in free feedback. If replicated in larger controlled trials, TÜTASS training might be a useful treatment tool for groups of children with ASD.

Hintergrund Partizipative Gesundheitsforschung (PGF) gewinnt zunehmend an Bedeutung. Durch die Beteiligung der zu beforschenden Zielgruppe können lebensweltnahe, praxisorientierte Ergebnisse generiert und gesundheitsbezogene Veränderungen angestoßen werden. Dies bietet auch Potenziale zur Verbesserung der Teilhabe und Gesundheit von Menschen mit Behinderungen. Viele Forschungsprojekte setzen jedoch nur niedrige Stufen der Partizipation um. Ziel des Beitrags Es werden Herausforderungen und entsprechende Lösungsansätze von PGF mit der Zielgruppe Menschen mit Behinderungen diskutiert. Der Beitrag soll Forschenden eine Orientierung zur Erreichung hoher Stufen von Partizipation bieten. Material und Methode Es wurde ein Modellvorhaben zur Entwicklung und Umsetzung gesundheitsfördernder Maßnahmen in Werkstätten für behinderte Menschen (WfbM) durchgeführt, das die Erreichung hoher Partizipationsstufen durch PGF mit Menschen mit Behinderungen zum Ziel hatte. Der Prozess wurde durch Interviews und Fragebögen evaluiert. Ergebnisse Herausforderungen waren die Diversität der in der Lebenswelt WfbM arbeitenden Menschen, komplexe Strukturen von WfbM, die Verfügbarkeit personeller, zeitlicher und finanzieller Ressourcen sowie lange Kommunikationswege. Der Einbezug der gesamten Lebenswelt, die Nutzung bekannter Kommunikationsmittel und ein häufiger Austausch mit den Beteiligten waren besonders zielführend. Für die Motivation sowie die Verstetigung der entwickelten Maßnahmen war die Wertschätzung gegenüber der Zielgruppe essenziell. Schlussfolgerungen Wenn die Herausforderungen von PGF überwunden werden, ermöglicht dies vielfältige Einblicke in die Lebenswelt von Menschen mit Behinderungen, bedarfs- und bedürfnisorientierte Gesundheitsförderung sowie hohe Motivation aller Beteiligten, diese umzusetzen., Background Participatory health research (PHR) is becoming increasingly important. Through participation of the target group in research, it is possible to generate real-world and practice-oriented results and to foster health-related changes. This can also serve to improve the participation and health of persons with disabilities. However, the participation levels in many existing PHR projects is low. Objectives We discuss challenges and opportunities in PHR with persons with disabilities. This article intends to provide an orientation for achieving high participation levels in health research. Methods To develop and implement health-promoting activities in workshops for persons with disabilities, a pilot project was conducted. The aim was to attain high participation levels through PHR with persons with disabilities. The process was evaluated using interviews and questionnaires. Results The diversity of the people who are working in the named workshops and especially of the persons with disability was identified as a challenge for PHR. Further challenges are the complex structures and communication lines of those workshops as well as the availability of staff, time and financial resources. Facilitating factors were the inclusion of all stakeholders of this living context, the use of known communication tools and frequent exchange. Appreciation towards the persons with disabilities seems to be one of the most important factors for their motivation and the permanent adoption of health-promoting activities. Conclusions If the challenges of PHR are overcome, this enables diverse insights into the lives of persons with disabilities. It facilitates the implementation of health-promoting activities according to the needs of the target group and fosters the motivation of participants.

Background We hypothesized that stroke outcome is related to multiple baseline hydration‐related factors including volume contracted state (VCS) and diuretic use. Methods and Results We analyzed a prospective cohort of subjects with ischemic stroke Conclusions A VCS at the time of hospitalization was associated with more severe stroke and odds of death but not associated with worse functional outcome when accounting for relevant characteristics. Diuretic use and low serum potassium at the time of stroke onset were associated with worse outcome and may be worthy of further investigation.

The trait impulsivity theory suggests that a single, highly heritable externalizing liability factor, expressed as temperamental trait impulsivity, represents the core vulnerability for externalizing disorders. The present study sought to test the application of latent factor models derived from this theory to a clinical sample of children. Participants were 474 German children (age 6-12 years, 81% male) with symptoms of attention-deficit/hyperactivity disorder and externalizing behavior problems participating in an ongoing multicenter intervention study. Using confirmatory factor analyses (CFA) and exploratory structural equation modeling (ESEM), we evaluated several factor models of externalizing spectrum disorders (unidimensional; first-order correlated factors; higher-order factor; fully symmetrical bifactor; bifactor S-1 model). Furthermore, we assessed our prevailing factor models for measurement invariance across raters (clinicians, parents, teachers) and assessment modes (interview, questionnaires). While both CFA and ESEM approaches provided valuable insights into the multidimensionality, ESEM solutions were generally superior since they showed a substantially better model fit and less biased factor loadings. Among the models tested, the bifactor S-1 CFA/ESEM models, with a general hyperactivity-impulsivity reference factor, displayed a statistically sound factor structure and allowed for straightforward interpretability. Furthermore, these models showed the same organization of factors and loading patterns, but not equivalent item thresholds across raters and assessment modes, highlighting cross-situational variability in child behavior. Our findings are consistent with the assumption of the trait impulsivity theory that a common trait, presented as hyperactivity-impulsivity symptoms, underlies all externalizing disorders. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Cognitive behavioral therapy (CBT) is the first choice of treatment of obsessive–compulsive disorder (OCD) in children and adolescents. However, there is often a lack of access to appropriate treatment close to the home of the patients. An internet-based CBT via videoconferencing could facilitate access to state-of-the-art treatment even in remote areas. The aim of this study was to investigate feasibility and acceptability of this telemedical approach. A total of nine children received 14 sessions of CBT. The first session took place face-to-face, the remaining 13 sessions via videoconference. OCD symptoms were recorded with a smartphone app and therapy materials were made accessible in a data cloud. We assessed diagnostic data before and after treatment and obtained measures to feasibility, treatment satisfaction and acceptability. Outcomes showed high acceptance and satisfaction on the part of patients with online treatment (89%) and that face-to-face therapy was not preferred over an internet-based approach (67%). The majority of patients and their parents classified the quality of treatment as high. They emphasized the usefulness of exposures with response prevention (E/RP) in triggering situations at home. The app itself was rated as easy to operate and useful. In addition to feasibility, a significant decrease in obsessive–compulsive symptoms was also achieved. Internet-based CBT for pediatric OCD is feasible and well received by the patients and their parents. Furthermore, obsessive–compulsive symptomatology decreased in all patients. The results of this study are encouraging and suggest the significance of further research regarding this technology-supported approach, with a specific focus on efficacy.Trial registration number: Clinical trials AZ53-5400.1-004/44.

The NEXT collaboration: et al., The Neutrino Experiment with a Xenon TPC (NEXT) searches for the neutrinoless double-beta (0νββ) decay of 136Xe using high-pressure xenon gas TPCs with electroluminescent amplification. A scaled-up version of this technology with about 1 tonne of enriched xenon could reach in less than 5 years of operation a sensitivity to the half-life of 0νββ decay better than 1027 years, improving the current limits by at least one order of magnitude. This prediction is based on a well-understood background model dominated by radiogenic sources. The detector concept presented here represents a first step on a compelling path towards sensitivity to the parameter space defined by the inverted ordering of neutrino masses, and beyond., The NEXT Collaboration acknowledges support from the following agencies and institutions: the European Research Council (ERC) under the Advanced Grant 339787-NEXT; the European Union’s Framework Programme for Research and Innovation Horizon 2020 (2014–2020) under the Grant Agreements No. 674896, 690575 and 740055; the Ministerio de Economía y Competitividad and the Ministerio de Ciencia, Innovación y Universidades of Spain under grants FIS2014-53371-C04, RTI2018-095979, the Severo Ochoa Program grants SEV-2014-0398 and CEX2018-000867-S, and the María de Maeztu Program MDM2016-0692; the Generalitat Valenciana of Spain under grants PROMETEO/2016/120 and SEJI/2017/011; the Portuguese FCT under project PTDC/FIS-NUC/2525/2014 and under projects UID/FIS/04559/2020 to fund the activities of LIBPhys-UC; the Pazy Foundation (Israel) under grants 877040 and 877041; the US Department of Energy under contracts number DE-AC02-06CH11357 (Argonne National Laboratory), DE-AC02-07CH11359 (Fermi National Accelerator Laboratory), DE-FG02-13ER42020 (Texas A&M) and DE-SC0019223 / DE-SC0019054 (University of Texas at Arlington); and the University of Texas at Arlington. DGD acknowledges support from the Ramón y Cajal program (Spain) under contract number RYC-2015-18820. JM-A acknowledges support from Fundación Bancaria la Caixa (ID 100010434), grant code LCF/BQ/PI19/11690012, and from the Plan GenT program of the Generalitat Valenciana, grant code CIDEGENT/2019/049.

Autism spectrum disorders (ASD) represent a set of long-lasting severe neurodevelopmental conditions and effective therapeutic interventions are needed. Recent research points to the importance of including mindfulness-based elements to improve emotion and body perception in the psychotherapy of patients with ASD. Therefore, we developed a structured group psychotherapy program The Tübinger Training for Autism Spectrum Disorders (Tübinger Training für Autismus-Spektrum-Störungen; TüTASS) which focuses on mindfulness-based training elements. This pilot study accompanying the TüTASS reports the first results on the feasibility of the program with a pre-post comparison of 25 treated children with ASD. The psychometric assessment comprised five standardized questionnaires/ scales evaluating on the basis of parents and patients self-reports the child’s social responsiveness, behavior, strengths and difficulties, quality of life, and depressive symptoms before and after training completion. The results indicated that upon training completion, symptoms with respect to emotional and social problems, externalizing behavior, and attentional and schizoid-compulsive behavior substantially declined. In a questionnaire assessing feasibility and quality of the group training, patients and parents found the therapy highly beneficial, especially as to the focus on emotions and body, and strengths and failures. This training program was developed to bridge the gap of lacking mindfulness-based interventions with the aim to optimize the course of ASD, especially with respect to behavioral disturbances and social-emotional problems.

Autorzy: Abe K., Adrich P., Aihara H., Akutsu, R., Alekseev I., Ali A. , Ameli F., Anghel I., Anthony L. H. V., Antonova M. , Araya A., Asaoka Y., Ashida Y., Aushev V., Ballester F., Bandac I., Barbi M., Barker G. J., Barr G., Batkiewicz-Kwasniak M., Bellato M., Berardi V., Bergevin M., Bernard L., Bernardini E., Berns L., Bhadra S., Bian J., Blanchet A., Blaszczyk F. d. M., Blonde A., Boiano A., Bolognesi S., Bonavera L., Booth N., Borjabad S., Boschi, T., Bose D., Boyd S . B., Bozza C., Bravar A., Bravo-Berguño D., Bronner C., Brown L., Bubak Arkadiusz, Buchowicz A., Buizza Avanzini M., Cafagna F. S., Calabria N. F., Calvo-Mozota J. M., Cao S., Cartwright S.L., Carroll A., Catanesi M. G., Cebriàn, S., Chabera M., Chakraborty, S., Checchia C., Choi J.H., Choubey S., Cicerchia M., Coleman J., Collazuol G., Cook L., Cowan G., Cuen-Rochin, S., Danilov M., Díaz López G., De la Fuente E., de Perio P., De Rosa G., Dealtry T., Densham C. J., Dergacheva A., Deshmukh N., Devi M. M., Di Lodovico F., Di Meo, P., Di Palma I., Doyle T. A., Drakopoulou E., Drapier O., Dumarchez J., Dunne P., Dziewiecki M., Eklund L., El Hedri S., Ellis J., Emery S., Esmaili A., Esteve R., Evangelisti A., Feely M., Fedotov S., Feng J., Fernandez P., Fernández-Martinez E., Ferrario P., Ferrazzi,B., Feusels T., Finch A., Finley C., Fiorentini A., Fiorillo G., Fitton M., Frankiewicz K., Friend M., Fujii Y., Fukuda Y., Galinski G., Gao J., Garde C., Garfagnini A., Garode S., Gialanella L., Giganti C., Gomez-Cadenas J.J., Gonin M., González-Nuevo J., Gorin A., Gornea R., Gousy-Leblanc V. Gramegna F. Grassi M. Grella G. Guigue M. Gumplinger P. Hadley D.R. Harada M., Hartfiel B., Hartz M., Hassani S., Hastings N.C., Hayato Y., Hernando-Morata J.A., Herrero V., Hill J., Hiraide K., Hirota S., Holin A., Horiuchi S., Hoshina K., Hultqvist K., Iacob F., Ichikawa A.K., Idrissi Ibnsalih W., Iijima T., Ikeda M., Inomoto M., Inoue K., Insler J., Ioannisian A., Ishida T., Ishidoshiro K., Ishino H., Ishitsuka M., Ito H., Ito S., Itow Y., Iwamoto K., Izmaylov A., Izumi N., Izumiyama S., Jakkapu M., Jamieson B., Jang H.I., Jang J.S., Jenkins S.J., Jeon S.H., Jiang M., Jo H.S., Jonsson P., Joo K.K., Kajita T., Kakuno H., Kameda J., Kano Y., Kalaczynski P., Karlen D., Kasperek J., Kataoka Y., Kato A., Katori T., Kazarian N., Kearns E., Khabibullin M., Khotjantsev A., Kikawa T., Kekic M., Kim J.H., Kim J.Y., Kim S.B., Kim S.Y., King S., Kinoshita T., Kisiel Jan, Klekotko A., Kobayashi T., Koch L., Koga M., Koerich L., Kolev N., Konaka A., Kormos L.L., Koshio Y., Korzenev A., Kotsar Y., Kouzakov K.A., Kowalik K.L., Kravchuk L., Kryukov A.P., Kudenko Y., Kumita T., Kurjata R., Kutter T., Kuze M., Kwak K., La Commara M., Labarga L., Lagoda J., Lamers James J., Lamoureux M., Laveder M., Lavitola L., Lawe M., Learned J.G., Lee J., Leitner R., Lezaun V., Lim I.T., Lindner T., Litchfield R.P., Long K.R., Longhin A., Loverre P., Lu X., Ludovici L., Maekawa Y., Magaletti L., Magar K., Mahn K., Makida Y., Malek M., Malinský M., Marchi T., Maret L., Mariani C., Marinelli A., Martens K., Marti L., Martin J.F. 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J. P., Sonoda Y., Spina R., Spisso B., Spradlin B., Stankevich K.L., Stawarz L., Stellacci S.M., Stopa K., Studenikin A.I., Suárez Gómez S.L., Suganuma T., Suvorov S., Suwa Y., Suzuki A.T., Suzuki S.Y., Suzuki Y., Svirida D., Svoboda R., Taani M., Tada M., Takeda A., Takemoto Y., Takenaka A., Taketa A., Takeuchi Y., Takhistov V., Tanaka H., Tanaka H.A., Tanaka H.I., Tanaka M., Tashiro T., Thiesse M., Thompson L.F., Toledo J., Tomatani-Sánchez A.K., Tortone G., Tsui K.M., Tsukamoto T., Tzanov M., Uchida Y., Vagins M.R., Valder S., Valentino V., Vasseur G., Vijayvargi A., Vilela C., Vinning W. G. S., Vivolo D., Vladisavljevic T., Vogelaar R.B., Vyalkov M.M., Wachala T., Walker J., Wark D., Wascko M.O., Wendell R.A., Wilkes R.J., Wilking M.J., Wilson M.R., Wronka S., Xia J., Xie Z., Xin T., Yamaguchi Y., Yamamoto K., Yanagisawa C., Yano T., Yen S., Yershov N., Yeum D.N., Yokoyama M., Yonenaga M., Yoo J., Yu I., Yu M., Zakrzewski T., Zaldivar B., Zalipska J., Zaremba K., Zarnecki G., Ziembicki M., Zietara K., Zito M., Zsoldos S., Core-collapse supernovae are among the most magnificent events in the observable universe. They produce many of the chemical elements necessary for life to exist and their remnants-neutron stars and black holes-are interesting astrophysical objects in their own right. However, despite millennia of observations and almost a century of astrophysical study, the explosion mechanism of core-collapse supernovae is not yet well understood. Hyper-Kamiokande is a next-generation neutrino detector that will be able to observe the neutrino flux from the next galactic core-collapse supernova in unprecedented detail. We focus on the first 500 ms of the neutrino burst, corresponding to the accretion phase, and use a newly-developed, high-precision supernova event generator to simulate Hyper-Kamiokandeʼs response to five different supernova models. We show that Hyper-Kamiokande will be able to distinguish between these models with high accuracy for a supernova at a distance of up to 100 kpc. Once the next galactic supernova happens, this ability will be a powerful tool for guiding simulations toward a precise reproduction of the explosion mechanism observed in nature.

Obsessive-compulsive disorder (OCD) in childhood and adolescence often leads to significant impairment in various areas of life and has a high risk of becoming chronic. Cognitive behavioral therapy (CBT) is the recommended first-line treatment, but it is too rarely implemented in accordance with guidelines and is often not available close to the patient's home. Importantly, internet-based CBT could help to reduce this gap in care. Having previously successfully demonstrated the feasibility of an internet-based CBT approach, we aimed to assess its effectiveness in a waiting list controlled randomized trial.Children and adolescents aged 6-18 years with a principal diagnosis of OCD received 14 sessions of therapist-delivered CBTA total of 60 children and adolescents were included into the analyses. Over the course of the treatment, OCD symptoms according to the CY-BOCS significantly decreased in the treatment group compared to the waiting-list control group. Cohen's d between groups was 1.63. After the patients in the waiting list group also received the treatment, the OCD symptoms decreased significantly in this group as well. This improvement of symptoms increased over the course of the follow-up assessments. Remission rate peaked at the 32-week follow-up, with 68% in the treatment group and 79% in the waiting list group. Importantly, patient satisfaction with treatment was high to very high.In our study, OCD symptoms decreased significantly and remission rate was high after internet-based CBT. Those effects were comparable to those found in studies of face-to-face treatment. Although further evidence is needed, these are early indications that our approach may be a viable way to provide access to adequate treatment for children and adolescents affected by OCD.[www.ClinicalTrials.gov], identifier [NCT05037344].

The birth of two eastern black rhinoceros (Diceros bicornis michaeli) calves (0.2) at the Blank Park Zoo in Des Moines, IA offered an opportunity to collect normative data for the first six months ...

Fracture toughness is one of the key parameters for the characterization of brittle rock fracturing. Yet, constraints on it mainly rest on measurements performed at ambient pressure, although rock fracturing frequently occurs at elevated pressures even in geotechnical applications. To address the lack of a generally accepted evaluation procedure for tests at elevated pressure we explored the conditions for initiation and propagation of mode I fractures in samples subjected to bending at elevated pressure by numerical modeling and analytical considerations of the involved angular moments. We derived an evaluation procedure and applied it to experimental observations for specimens with either a chevron or a single-edge notch of four different rocks (a granite, a limestone, a marble and a sandstone) subjected to three-point bending at confining pressures up to 30 MPa. Two sealing methods were considered. Specimens were either varnished or jacketed by a rubber tube, differing in whether pressure is allowed to build up inside the pre-fabricated notch or not, respectively. Irrespective of notch geometry and sealing method, the determined toughness values increase significantly with confining pressure. The apparent toughness determined for jacketed specimens is, however, larger than that for varnished specimens, for which toughness seems to reach a plateau with increasing pressure. The similarity of the pressure dependence of the toughness determined for varnished, i.e., uniformly pressurized, samples with that of other physical properties suggests that it is controlled by the closure of pre-existing micro-cracks; the absence of pressure dependence beyond some tens of MPa suggests that non-linearity effects may not be as severe at depths beyond a few kilometers as previously discussed. Our study points to the necessity of resolving numerical issues associated with compressed fractures and of further improving experimental facilities for the determination of fracture toughness at elevated pressure.

Polytetrafluoroethylene (PTFE) is an excellent diffuse reflector widely used in light collection systems for particle physics experiments. In noble element systems, it is often coated with tetraphenyl butadiene (TPB) to allow detection of vacuum ultraviolet scintillation light. In this work this dependence is investigated for PTFE coated with TPB in air for light of wavelengths of 200 nm, 260 nm, and 450 nm. The results show that TPB-coated PTFE has a reflectance of approximately 92% for thicknesses ranging from 5 mm to 10 mm at 450 nm, with negligible variation as a function of thickness within this range. A cross-check of these results using an argon chamber supports the conclusion that the change in thickness from 5 mm to 10 mm does not affect significantly the light response at 128 nm. Our results indicate that pieces of TPB-coated PTFE thinner than the typical 10 mm can be used in particle physics detectors without compromising the light signal.

[EN] Convolutional neural networks (CNNs) are widely used state-of-the-art computer vision tools that are becoming increasingly popular in high-energy physics. In this paper, we attempt to understand the potential of CNNs for event classification in the NEXT experiment, which will search for neutrinoless double-beta decay in Xe-136. To do so, we demonstrate the usage of CNNs for the identification of electron-positron pair production events, which exhibit a topology similar to that of a neutrinoless double-beta decay event. These events were produced in the NEXT-White high-pressure xenon TPC using 2.6 MeV gamma rays from a Th-228 calibration source. We train a network on Monte Carlo-simulated events and show that, by applying on-the-fly data augmentation, the network can be made robust against differences between simulation and data. The use of CNNs offers significant improvement in signal efficiency and background rejection when compared to previous non-CNN-based analyses, This study used computing resources from Artemisa, co-funded by the European Union through the 2014-2020 FEDER Operative Programme of the Comunitat Valenciana, project DIFEDER/2018/048. This research used resources of the Argonne Leadership Computing Facility, which is a DOE Office of Science User Facility supported under Contract DE-AC02-06CH11357. The NEXT collaboration acknowledges support from the following agencies and institutions: Xunta de Galicia (Centro singularde investigacion de Galicia accreditation 2019-2022), by European Union ERDF, and by the "Maria de Maeztu" Units of Excellence program MDM-2016-0692 and the Spanish Research State Agency"; the European Research Council (ERC) under the Advanced Grant 339787-NEXT; the European Union's Framework Programme for Research and Innovation Horizon 2020 (2014-2020) under the Grant Agreements No. 674896, 690575 and 740055; the Ministerio de Economia y Competitividad and the Ministerio de Ciencia, Innovacion y Universidades of Spain under grants FIS2014-53371-C04, RTI2018-095979, the Severo Ochoa Program grants SEV-20140398 and CEX2018-000867-S; the GVA of Spain under grants PROMETEO/2016/120 and SEJI/2017/011; the Portuguese FCT under project PTDC/FIS-NUC/2525/2014 and under projects UID/FIS/04559/2020 to fund the activities of LIBPhys-UC; the U.S. Department of Energy under contracts number DE-AC02-07CH11359 (Fermi National Accelerator Laboratory), DE-FG02-13ER42020 (Texas A&M) and DE-SC0019223/DE SC0019054 (University of Texas at Arlington); and the University of Texas at Arlington. DGD acknowledges Ramon y Cajal program (Spain) under contract number RYC-2015 18820. JMA acknowledges support from Fundacion Bancaria "la Caixa" (ID 100010434), grant code LCF/BQ/PI19/11690012. We also warmly acknowledge the Laboratori Nazionali del Gran Sasso (LNGS) and the Dark Side collaboration for their help with TPB coating of various parts of the NEXT-White TPC. Finally, we are grateful to the Laboratorio Subterraneo de Canfranc for hosting and supporting the NEXT experiment.

During reintegration to daily school life following psychiatric hospitalization, children and adolescents are confronted with various challenges and are at risk for rehospitalization. Tailored post-discharge services could support a successful readjustment and accompany the high-risk transition period after discharge. The study DigiPuR ("Digital gestützte Psychotherapie und Reintegration," digitally supported psychotherapy and reintegration) aims to establish and to evaluate an innovative digital aftercare program to alleviate challenges during reintegration and improve cross-sectoral care.DigiPuR is a randomized controlled trial comparing a digital aftercare service with regular aftercare (TAU) (planned N = 150, 25 children/adolescents, 25 parents, and 25 teachers in each group). In the intervention group, direct communication via secure and regular video calls until 8 weeks after discharge and a secure messenger system between the hospital, family, and school, as well as, if needed, external support systems, are established. A longitudinal pre-post-follow-up assessment at admission, discharge, and 8, 24, and 36 weeks after discharge takes place supplemented by a daily smartphone-based ambulatory assessment from a triadic perspective of patients, parents, and teachers. Primary outcomes include whether participants in the intervention group have fewer readmissions and higher treatment satisfaction and health-related quality of life as well as lower symptom severity than participants in the control group.The present study is essential to address the cross-sectoral challenges associated with reintegration into daily (school) life following child and adolescent psychiatric hospitalization and to determine possible needed adaptations in partial or full inpatient settings. If applicability and efficacy of the aftercare service can be demonstrated, integration into regular care will be sought.ClinicalTrials.gov NCT04986228 . Registered on August 2, 2021.