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5. Estudio comparativo clínico y biomecánico de distintos tipos de osteosíntesis en el tratamiento de fracturas distales de fémur

Author

B. Redondo-Trasobares, M. Sarasa-Roca, J. Rosell-Pradas, J. Calvo-Tapies, L. Gracia-Villa, and J. Albareda-Albareda

Subjects
Distal femur fractures, Finite elements, Osteosynthesis, Intramdullary nail, Angular stable plate, Nail, Orthopedic surgery, RD701-811
Abstract

Resumen: Introducción y objetivos: Las fracturas de fémur distal representan un problema por su elevado número de complicaciones. El objetivo fue comparar los resultados, las complicaciones y la estabilidad conseguidos con el enclavado intramedular retrógrado y la placa de estabilidad angular en el tratamiento de las fracturas diafisarias distales de fémur. Material y método: Se realizó un estudio clínico y experimental biomecánico mediante elementos finitos. Los resultados de las simulaciones permitieron obtener los principales resultados relacionados con la estabilidad de la osteosíntesis. En el seguimiento clínico se utilizaron frecuencias en variables cualitativas, y la prueba exacta de Fisher y la prueba χ2 para evaluar la significación de los diferentes factores, con la condición p

Published
2023
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6. [Translated article] Comparative clinical and biomechanical study of different types of osteosynthesis in the treatment of distal femur fractures

Author

B. Redondo-Trasobares, M. Sarasa-Roca, J. Rosell-Pradas, J. Calvo-Tapies, L. Gracia-Villa, and J. Albareda-Albareda

Subjects
Fractura fémur distal, Elementos finitos, Osteosíntesis, Enclavado intramedular, Placa de estabilidad angular, Clavo, Orthopedic surgery, RD701-811
Abstract

Introduction and objectives: Distal femoral fractures represent a problem due to their high number of complications. The aim was to compare the results, complications and stability achieved with retrograde intramedullary nailing and the angular stable plate in the treatment of distal femoral diaphyseal fractures. Material and method: A clinical and experimental biomechanical study was carried out using finite elements. The results of the simulations allowed us to obtain the main results related to the stability of osteosynthesis. For clinical follow-up data, frequencies were used for qualitative variables, and Fisher's exact test and χ2 test were used to evaluate the significance of the different factors, with the condition of P

Published
2023
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7. El hormigón armado en Cataluña (1898-1929): cuatro empresas y su relación con la arquitectura

Author

R. Graus, H. Martín Nieva, and J. Rosell

Subjects
historia de la arquitectura, historia de la construcción, hormigón armado, monier, hennebique, construcción catalana, Architecture, NA1-9428, Building construction, TH1-9745
Abstract

Entre 1898 y 1929 se desarrollaron en Cataluña variadas iniciativas empresariales que introdujeron el hormigón armado en la arquitectura. En el artículo se estudian las empresas Anónima Claudio Duran - Construcciones Monier, Marial Hermanos - Sociedad Colectiva, Construcciones y Pavimentos, S. A., y Material y Obras, S. A. Se propone una aproximación al entramado productivo que estudie las empresas, sus técnicos y sus obras en toda su complejidad con la intención de valorar cómo el hormigón armado transformó el sector de la construcción, con nuevas empresas de otra escala productiva. Sin embargo, el ciclo económico depresivo 1929-1952 lastró estas iniciativas y alargó artificialmente los restos de la tradicional «construcción catalana».

Published
2017
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8. Influence of plate size and screw distribution on the biomechanical behaviour of osteosynthesis by means of lateral plates in femoral fractures

Author

J. Rosell-Pradas, B. Redondo-Trasobares, M. Sarasa-Roca, J. Albareda-Albareda, S. Puértolas-Broto, A. Herrera-Rodríguez, and L. Gracia-Villa

Subjects
General Earth and Planetary Sciences, General Environmental Science
Abstract

Distal femoral fractures are fractures associated with high rates of morbidity and mortality, affecting to three different groups of individuals: younger people suffering high-energy trauma, elderly people with fragile bones and people with periprosthetic fractures around previous total knee arthroplasty. They have been classically treated with conventional plates and intramedullary nails and more recently with locked plates that have increased their indications to more types of fractures. The main objective of the present work is the biomechanical study, by means of finite element simulation, of the stability achieved in the osteosynthesis of femoral fractures in zones 4 and 5 of Wiss, by using locked plates with different plate lengths and different screw configurations, and analysing the effect of screw proximity to the fracture site. A three dimensional (3D) finite element model of the femur from 55-year-old male donor was developed, and then a stability analysis was performed for the fixation provided by Osteosynthesis System LOQTEC® Lateral Distal Femur Plate in two different fracture zones corresponding to the zones 4 and 5 according to the Wiss fracture classification. The study was focused on the immediately post-operative stage, without any biological healing process. The obtained results show that more stable osteosyntheses were obtained by using shorter plates. In the cases of longer plates, it results more convenient disposing screws in a way that the upper ones are closer to fracture site. The obtained results can support surgeons to understand the biomechanics of fracture stability, and then to guide them towards the more appropriate osteosynthesis depending on the fracture type and location.

Published
2023
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9. Mid- to long-term results of SuPerLap single-port treatment in inguinal hernia

Author

R A, Hernández-Rodríguez, M J, Rosell Echevarría, F D, Ravelo Díaz, V, Villamil, and E L, Pérez-Etchepare Figueroa

Subjects
Male, Treatment Outcome, Recurrence, Child, Preschool, Infant, Newborn, Humans, Hernia, Inguinal, Laparoscopy, Herniorrhaphy, Retrospective Studies
Abstract

Laparoscopic treatment of inguinal hernia is gaining popularity in many hospitals, but the use of working channel scopes is not as widely extended. We present our long-term experience with the SuPerLap (laparoscopic-assisted percutaneous suture) technique described by Rosell et al.(1) for epigastric hernia repair in the percutaneous, single-port treatment of inguinal hernia using working channel scopes.A retrospective analysis of a series of male patients with congenital inguinal hernia undergoing surgery from February 2017 to December 2020 was carried out. A 5 mm-0º pleuroscope with a 3.5 mm working channel, a 20 G epidural needle, a 36 cm/3.5 mm laparoscopic Maryland dissector, and 3-0 polypropylene and polyester sutures were used.384 inguinal hernia repairs using the SuPerLap technique were performed in 295 male patients - 206 unilateral repairs and 89 bilateral repairs. In 24 bilateral cases (26.95%), preoperative diagnosis had been unilateral. Mean age was two years (2 weeks-13 years). Mean operating time was 14 minutes (6-50 min) for unilateral repair, and 27 minutes (14-80 min) for bilateral repair. There were two cases of epigastric vessel damage, and one case of early recurrence in a newborn, who successfully underwent re-intervention using the SuPerLap technique. No late complications were recorded after a mean follow-up of 1-36 months.Working channel scopes using the SuPerLap technique avoid additional ports in inguinal hernia repair. They allow for excellent functional results, without visible scars, and minimize spermatic cord manipulation. Laparoscopy allows previously undiagnosed defects to be concomitantly treated.La laparoscopia en el tratamiento de la hernia inguinal está cada vez más presente en muchos hospitales. El uso de ópticas con canal de trabajo no está tan extendido. Se presenta la experiencia a largo plazo en la aplicación de la técnica SuPerLap (sutura percutánea laparoasistida) propuesta por Rosell y cols.(1) para la reparación de hernias epigástricas en el tratamiento monopuerto, percutáneo de las hernias inguinales mediante el uso de ópticas con canal de trabajo.Serie quirúrgica de hernia inguinal congénita en varones (febrero de 2017-diciembre de 2020). Se utilizó: pleuroscopio de 5 mm-0º con canal de trabajo de 3,5 mm; aguja epidural 20 G; suturas de polipropileno y poliéster 3/0; disector Maryland laparoscópico (36 cm-3,5 mm).Se realizaron 384 herniorrafias inguinales según técnica SuPerLap en 295 varones (206 unilaterales, 89 bilaterales). En 24 casos bilaterales (26,95%) el diagnóstico preoperatorio fue unilateral. La edad media fue de dos años (2 semanas-13 años). El tiempo medio quirúrgico fue 14 minutos (6-50 min) en unilaterales, 27 (14-80 min) en bilaterales. Hubo dos casos de lesión de vasos epigástricos y una recidiva precoz en un neonato, reintervenido satisfactoriamente mediante técnica SuPerLap. En un seguimiento de 1-36 meses no hubo complicaciones tardías.El uso de ópticas con canal de trabajo según técnica SuPerLap posibilita prescindir de puertos adicionales en el tratamiento de la hernia inguinal. Permite resultados funcionales comparables y cirugía sin cicatrices visibles. Minimiza la manipulación del cordón espermático. La laparoscopia permite el tratamiento concomitante de defectos no diagnosticados previamente.

Published
2022
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10. A closed-chest model of selective atrial myocardial infarction for the study of induced electrophysiological and structural derangements

Author

G Amoros-Figueras, S Casabella-Ramon, G Company, D Arzamendi, Y Macias, E Jorge, D Sanchez-Quintana, J Rosell-Ferrer, J M Guerra, and J Cinca

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Background The diagnosis of atrial infarction is often masked by the frequent association with ventricular infarction. For this reason, the electrophysiological and structural consequences of selective atrial ischemia are poorly understood. Purpose The objective of this study was to analyze the alterations in the ECG, local electrograms, and multifrequential atrial myocardial impedance in a new experimental model of acute and chronic atrial infarction. Methods Seven anesthetized pigs were subjected to 4h of atrial ischemia induced by selective catheter occlusion of the atrial coronary branches originating in the left circumflex coronary artery. The surface ECG was recorded and the changes in P-wave morphology analyzed. Four weeks later the animals were subjected to endocardial voltage mapping (Carto) and multifrequential impedance. The hearts were processed for anatomopathological study. Results Selective occlusion of the coronary atrial branches induced atrial infarction with fibrosis in the left atrium in 6 of the 7 cases (Figure). The surface ECG showed prolongation of the P-wave duration (Figure) (P-wave in lead II: from 72±8ms at baseline vs. 97±18ms at 4 weeks, ANOVA p Conclusion We developed a closed-chest swine model of selective atrial infarction suitable for the study of ECG patterns and electrophysiological mechanisms linked to atrial myocardial ischemia and infarction. The structural derangements are detectable by endocardial mapping of local voltage electrograms and local tissue impedance. Funding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Supported by grants from ISCI-MINECO (FIS PI17/00069), FEDER, CIBERCV (CB16/11/00276)

Published
2022
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11. Real-time electrophysiological characterization of acute and chronic radiofrequency ablation lesions

Author

G Amoros-Figueras, S Casabella-Ramon, Z Moreno-Weidmann, G Company-Ramon, E Jorge, J Rosell-Ferrer, J Cinca, and J M Guerra

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Background Assessment of lesion formation remains one of the most important goals to guide radiofrequency (RF) procedures in the cardiac electrophysiology laboratory. Cardiac navigation systems use specific algorithms to predict the effective lesion size, but these metrics are based only on ablation parameters and ignore local electric tissue characteristics. [1] Recent studies show that local multiparametric impedance is influenced by the intrinsic structural characteristics of the tissue. [2] Purpose This study aimed to assess the ability of local multiparametric impedance to characterize acute and chronic RF ablation lesions in the right atrium of pigs. Methods Four anesthetized closed-chest pigs were submitted to two interventions. The first intervention aimed at creating RF ablation lesions (30W, 60s, 55°) in the right atrium using an electrocatheter connected to a conventional cardiac navigation system, while mapping the local multiparametric impedance (LMI), the generator impedance (GI) and the bipolar voltage (BiV). All RF ablation lesions were performed with a stable contact force. Four weeks later, the second intervention aimed at mapping again the previous ablation sites. After the second intervention animals were euthanized and the hearts were removed and processed to identify the presence of fibrosis in the previously ablated lesions (Figure). Results We performed 19 ablations (5±2 per animal) with an average contact force of 14.2±4.6g. Four weeks later, 14/19 (74%) ablation lesions were identified as fibrotic points in the explanted heart (Figure 1). These showed decreased acute LMI and BiV values that persisted low after 4 weeks (Table 1). The remaining 5/19 ablations that did not present fibrosis had lower baseline LMI and bipolar values that resulted in lower LMI and BiV drops (Table 1). The absolute drop in LMI between effective and non-effective lesions was around 50%, while GI drop was only 21% (LMI drop @51KHz: From −3.0±1.4° to −1.5±0.3°, T-TEST p Conclusion The local baseline electrical properties of atrial myocardium are directly related to the effectiveness of RF ablation lesions. RF ablation sites that resulted into persistent fibrosis points had larger LMI and BiV values, with higher absolute drops than non-effective lesions. The use of LMI in clinical practice could improve the outcome of the procedures of arrhythmia ablation in the electrophysiology lab. Funding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Supported by grants from ISCI-MINECO (FIS PI21/00392), FEDER, CIBERCV (CB16/11/00276)

Published
2022
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12. Monodisperse droplets and particles by efficient neutralization of electrosprays

Author

Enginyeria Química, Universitat Rovira i Virgili, Carrasco-Munoz A; Barbero-Colmenar E; Bodnár E; Grifoll J; Rosell-Llompart J, Enginyeria Química, Universitat Rovira i Virgili, and Carrasco-Munoz A; Barbero-Colmenar E; Bodnár E; Grifoll J; Rosell-Llompart J

Abstract

We present a new approach for micro- and nanoparticle production by in-situ charge reduction of electrospray droplets, which prevents their Coulombic instabilities and allow the efficient transport (extraction) of the particles. A unipolar ion source based on corona discharge generates a controllable ion flux of opposite polarity to the electrospray. The ions are introduced axially into the spray, while the Taylor cone is screened from the ions by an extractor ring electrode. Efficient and steady droplet discharge and extraction through an orthogonal aerosol-extraction tube was attained when the inlet of the tube was near the spray emission and the ring electrode, resulting in dramatic changes in droplets’ trajectories. The best extraction conditions (highest filter collections) were associated with the best discharging (lowest residual electrical charge) and the most globular particles. The size distributions on the particles collected on the filters were monomodal and homogeneous, with small relative standard deviations (as small as 10.6%). The use of corona ions significantly expands the range of polymer concentrations over which globular particles with monomodal size distribution can be made by electrospray. © 2021 Elsevier Ltd

Published
2022

14. New insights in Neanderthal palaeoecology using stable oxygen isotopes preserved in small mammals as palaeoclimatic tracers in Teixoneres Cave (Moià, northeastern Iberia)

Author

M. Fernández-García, J. M. López-García, A. Royer, C. Lécuyer, F. Rivals, A. Rufà, R. Blasco, J. Rosell, Grupo de I+D+i Evolución Humana y Adaptaciones Económicas y Ecológicas durante la Prehistoria (EVOADAPTA ), Universidad de Cantabria [Santander], Institut Català de Paleoecologia Humana i Evolució Social (IPHES), Área de prehistòria, Departament d'història i història de l'Art, Universitat Rovira i Virgili, Biogéosciences [UMR 6282] (BGS), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement (LGL-TPE), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Institució Catalana de Recerca i Estudis Avançats (ICREA), Interdsciplinay Center for Archaeology and the Evolution of Human Behaviour (ICArEHB), De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie (PACEA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), and Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature.

Subjects
Archeology, Southwestern Europe, Geochemistry, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, [SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry, Anthropology, Taphonomy, Palaeoenvironment, Middle Palaeolithic
Abstract

AbstractThe northeastern region of Iberia constitutes a natural pass-area for arriving populations into the peninsula and becomes a key area to understand Neanderthal resilience to changing environmental conditions experienced during Marine Isotope Stage 3 (MIS 3; 60–30 ka). Short-term but repeated occupations by Neanderthal groups occurred in Teixoneres Cave (Moià, Barcelona) in alternation with large and small carnivores during MIS3. Abundant small-mammal remains accumulated in units III and II of this fossiliferous deposit, providing local climatic and environmental information. This work focuses on the taphonomic history of small-mammal faunas, which a is clue to validate previous palaeoecological interpretations. As was observed with leporids and bird remains, raptors are considered the major source of small-mammal remains. The most likely accumulator is an opportunistic predator, the eagle owl, with very rare inputs by mammalian carnivores. In parallel, high-resolution palaeoclimatic data are provided through oxygen isotope analyses (δ18O) of rodent teeth from four subunits (IIIb to IIa), which are compared with independent methods of palaeotemperature estimations. According to air temperatures estimated from δ18O rodent teeth, cooler conditions than present day (− 1.6/ − 0.5 °C) are recorded along the sequence, but homogenous (

Published
2022
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16. Subject Retention in Prehospital Stroke Research Using a Telephone-Based Physician-Investigator Driven Enrollment Method

Author

Scott Hamilton, Sidney Starkman, Nerses Sanossian, Marc Eckstein, Bryant J Rosell, David S Liebeskind, Kristina Shkirkova, Latisha K Sharma, Jeffrey L. Saver, Robin Conwit, and May Kim-Tenser

Subjects
medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, Patient Dropouts, Time Factors, Ambulances, Phases of clinical research, 030204 cardiovascular system & hematology, California, Consent, 03 medical and health sciences, Magnesium Sulfate, 0302 clinical medicine, Informed consent, medicine, Emergency medical services, Humans, Stroke, Acute stroke, Original Paper, Informed Consent, business.industry, Patient Selection, Subject (documents), Explicit consent, medicine.disease, Research Personnel, Clinical trial, Emergency Medical Technicians, Neuroprotective Agents, Treatment Outcome, Neurology, lcsh:RC666-701, Physical therapy, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery, Cell Phone
Abstract

Background and Purpose: Subject retention into clinical trials is vital, and prehospital enrollment may be associated with higher rates of subject withdrawal than more traditional methods of enrollment. We describe rates of subject retention in a prehospital trial of acute stroke therapy. Methods: All subjects were enrolled into the NIH Field Administration of Stroke Therapy-Magnesium (FAST-MAG) phase 3 clinical trial. Paramedics screened eligible subjects and contacted the physician-investigator using a dedicated in-ambulance cellular phone. Physician-investigators obtained explicit informed consent from the subject or on-scene legally authorized representative (LAR) who reviewed and signed a consent form. Exception from informed consent (EFIC) was utilized in later stages of the study. Results: There were 1,700 subjects enrolled; 1,017 provided consent (60%), 662 were enrolled via LAR (39%), and 21 were enrolled via EFIC (1%). Of the 1,700 patients, 1,413 (83%) completed the 90-day visit, 265 (16%) died prior to the 90-day visit, and 22 (1.3%) withdrew from the study before completion. There were no differences in rates of withdrawal by method of study enrolment, i.e., self-consent (n = 14), 1.4%; LAR (n = 8), 1.2%; EFIC (n = 0) 0%. Conclusion: There was a high rate of retention when subjects were enrolled into prehospital stroke research using a phone-based method to obtain explicit consent.

Published
2019

17. Examining Neanderthal and carnivore occupations of Teixoneres Cave (Moia, Barcelona, Spain) using archaeostratigraphic and intra-site spatial analysis

Author

Universitat Rovira i Virgili, Zilio, Leandro; Hammond, Heidi; Karampaglidis, Theodoros; Sanchez-Romero, Laura; Blasco, Ruth; Rivals, Florent; Rufa, Anna; Picin, Andrea; Chacon, M. Gema; Demuro, Martina; Arnold, Lee J.; Rosell, Jordi, Universitat Rovira i Virgili, and Zilio, Leandro; Hammond, Heidi; Karampaglidis, Theodoros; Sanchez-Romero, Laura; Blasco, Ruth; Rivals, Florent; Rufa, Anna; Picin, Andrea; Chacon, M. Gema; Demuro, Martina; Arnold, Lee J.; Rosell, Jordi

Abstract

Teixoneres Cave (Moia, Barcelona, Spain) is a reference site for Middle Palaeolithic studies of the Iberian Peninsula. The cave preserves an extensive stratigraphic sequence made up of eight units, which is presented in depth in this work. The main goal of this study is to undertake an initial spatial examination of Unit III, formed during Marine Isotope Stage 3, with the aim of understanding spatial organization and past activities developed by Neanderthals and carnivores (bears, hyenas and smaller carnivores). The total sample analysed includes 38,244 archaeological items and 5888 limestone blocks. The application of GIS tools allows us to clearly distinguish three geologically-defined stratigraphic subunits. Unit III has been previously interpreted as a palimpsest resulting from alternating occupation of the cave by human groups and carnivores. The distribution study shows that faunal specimens, lithic artefacts, hearths and charcoal fragments are significantly concentrated at the entrance of the cave where, it is inferred, hominins carried out different activities, while carnivores preferred the sheltered zones in the inner areas of the cave. The results obtained reveal a spatial pattern characterized by fire use related zones, and show that the site was occupied by Neanderthals in a similar and consistent way throughout the (>)7000 years range covered by the analysed subunits. This spatial pattern is interpreted as resulting from repeated short-term human occupations.

Published
2021

19. A new approach for initial callus growth during fracture healing in long bones

Author

Jorge Albareda, Luis Gracia, Sergio Puértolas, Elena Ibarz, A. Hidalgo, J. M. Naveiro, and J. Rosell

Subjects
Fracture Healing, Callus formation, Health Informatics, Context (language use), Bone healing, Bone fracture, medicine.disease, Fracture Fixation, Intramedullary, Computer Science Applications, Bone remodeling, Mesh generation, Callus, Fracture (geology), medicine, Animals, Humans, Bony Callus, Biological system, Femoral Fractures, Algorithms, Software, Mathematics
Abstract

The incidence of bone fracture has become a major clinical problem on a worldwide scale. In the past two decades there has been an increase in the use of computational tools to analyse the bone fracture problem. In several works, various study cases have been analysed to compare human and animal bone fracture healing. Unfortunately, there are not many publications about computational advances in this field and the existing approaches to the problem are usually similar. In this context, the objective of this work is the application of a diffusion problem in the model of the bone fragments resulting from fracture, working together with a mesh-growing algorithm that allows free growth of the callus depending on the established conditions, without a pre-meshed domain. The diffusion problem concerns the different biological magnitudes controlling the callus growth, among which Mesenchymal Stem Cells and chondrocytes concentrations were chosen, together with Tumour Necrosis Factor α and Bone Morphogenetic Protein as the factors influencing the velocity in the callus formation. A Finite Element approach was used to solve the corresponding diffusion problems, obtaining the concentration values along the entire domain and allowing detecting the zones in which biological magnitudes reach the necessary thresholds for callus growth. The callus growth is guided by a geometrical algorithm which performs an additional mesh generation process (self-added mesh) at each step of the iterative procedure until complete callus formation. The proposed approach was applied to different types of diaphyseal femoral fractures treated by means of intramedullary nailing. Axisymmetric models based on triangular quadratic elements were used, obtaining results in good agreement with clinical evidence of these kinds of fractures. The algorithm proposed has the advantage of a natural callus growth, without the existence of a previous mesh that may affect the conditions and direction of growth. The approach is intended for the initial phase of callus growth. Future work will address the implementation of the corresponding formulations for tissue transformation and bone remodelling in order to achieve complete fracture healing.

Published
2021
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20. Raman spectroscopy of alpha-FeOOH (goethite) near antiferromagnetic to paramagnetic phase transition

Author

V. G. Ivanov, N. D. Todorov, B. S. Stefanov, Miroslav Abrashev, Vassil Skumryev, and J. Rosell

Subjects
010302 applied physics, Phase transition, Condensed Matter - Materials Science, Materials science, Scattering, Phonon, General Physics and Astronomy, Materials Science (cond-mat.mtrl-sci), FOS: Physical sciences, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Molecular physics, Condensed Matter - Other Condensed Matter, symbols.namesake, Paramagnetism, Molecular vibration, 0103 physical sciences, symbols, Antiferromagnetism, Condensed Matter::Strongly Correlated Electrons, 0210 nano-technology, Raman spectroscopy, Néel temperature, Other Condensed Matter (cond-mat.other)
Abstract

Synthetic powder, ore samples, and mineral single crystals of goethite ( α-FeOOH) were investigated with polarized Raman spectroscopy at temperatures from 293 K to 473 K. The symmetry of the vibrational modes, observed in different scattering configurations, was determined unequivocally. The assignment of the Raman-active modes to definite atomic vibrations is supported by two types of lattice-dynamical calculations: empirical shell model and ab initio density functional theory. The temperature dependencies of the line shape parameters of some Raman-active vibrations at temperatures near to the antiferromagnetic–paramagnetic phase transition infers for a significant spin–lattice coupling in this compound. The most informative in this aspect is the B 3 g phonon at 387 cm − 1, which overlays a broad scattering background and displays a pronounced asymmetric Fano-line shape. The asymmetry increases in the paramagnetic state above the Neel temperature ( T N = 393 K), indicating a strong interaction of this mode with the underlying excitation continuum. The origin of the excitation background is discussed in light of our experimental results and the existing data for the magnetic structure and transport properties of α-FeOOH. By using the molecular-orbital dimer approach, we calculate the spin–phonon coupling constants for the B 3 g mode as J ′ = − 0.2 eV / A and J ″ = + 0.18 eV / A 2, respectively. Thus, we rationalize that, most probably, the scattering background stems from magnetic excitations, and the asymmetric shape of the B 3 g band is a result of a linear spin–phonon coupling of this mode with the Fe–O1–Fe spin dimers. Another mechanism, a phonon interaction with thermally activated charge carriers above T N, is also considered.

Published
2020

21. Biomechanical analysis of the stability of anterograde reamed intramedullary nails in femoral spiral fractures

Author

Antonio Herrera, Luis Gracia, Sergio Gabarre, J. Rosell, Jesús Mateo, Jorge Albareda, and Elena Ibarz

Subjects
Male, Models, Anatomic, Finite Element Analysis, Bone healing, Bone Nails, law.invention, Intramedullary rod, 03 medical and health sciences, Femoral head, 0302 clinical medicine, Imaging, Three-Dimensional, law, medicine, Humans, Femur, Spiral, General Environmental Science, Orthodontics, Fracture Healing, 030222 orthopedics, Osteosynthesis, business.industry, Spiral fracture, 030208 emergency & critical care medicine, Middle Aged, medicine.disease, Biomechanical Phenomena, Fracture Fixation, Intramedullary, medicine.anatomical_structure, Treatment Outcome, General Earth and Planetary Sciences, Cortical bone, Stress, Mechanical, business, Femoral Fractures
Abstract

Femoral shaft fractures present high morbidity and important complications and consequences, being spiral fractures the most complicated from a biomechanical point of view, being unstable and without possibility of getting a good contact between nail and femoral endosteum. Femoral diaphyseal fractures are treated, usually, by means of intramedullary nailing. So, it is necessary to know the osteosynthesis stability and which locking screws combination is optimal. This work studies the use of reamed locked intramedullary nails in spiral femoral fractures located along zones 2 and 4 of wiss, depending on the spire length, corresponding to 32-A spiral type in AO/OTA classification, which represent a percentage of 23% within the total of diaphyseal fractures. A three-dimensional finite element model of the femur was developed, modeling a spiral fracture with different spiral lengths and gaps. A femoral nail was used, considering two transversal screws both at the proximal and the distal parts. The study was focused on the immediately post-operative stage, verifying the appropriate stability of the osteosynthesis. Reamed intramedullary blocked nails provide appropriate stability of femoral spiral fractures, considering global mobility of femoral head with respect to femoral condyles, relative displacements between fragments at fracture site, stresses at nail and locking screws, and stresses at cortical bone. The obtained results show that the use of blocked reamed nails in spiral femoral fractures can be considered as an appropriate surgical technique, providing sufficient stability in order to obtain an adequate fracture healing.

Published
2019

22. Mid- to long-term results of SuPerLap single-port treatment in inguinal hernia.

Author

Hernández-Rodríguez, R. A., Echevarría, M. J. Rosell, Díaz, F. D. Ravelo, Villamil, V., and Figueroa, E. L. Pérez Etchepare

Subjects
LONG-term health care, INGUINAL hernia, CHILD patients, LAPAROSCOPIC surgery, HOSPITALS
Abstract

Copyright of Cirugía Pediátrica (English Edition) is the property of Sociedad Espanola de Cirurgia Pediatrica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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24. Abstract WP256: High Rate of Subject Retention into Prehospital Stroke Research with Telephone-based Physician-investigator Driven Enrollment

Author

Nerses Sanossian, Fast-Mag Investigators, Bryant J Rosell, David S Liebeskind, Scott Hamilton, Sidney Starkman, Latisha K Sharma, Jeffrey L. Saver, Robin Conwit, and May Kim-Tenser

Subjects
Advanced and Specialized Nursing, High rate, Clinical trial, Informed consent, business.industry, medicine, Subject (documents), Neurology (clinical), Medical emergency, Cardiology and Cardiovascular Medicine, medicine.disease, business, Stroke
Abstract

Background: Explicit informed consent for prehospital research can be achieved by physician-investigators using cellular phones to communicate with potential subjects or legally authorized representatives (LAR). Subject retention into clinical trials is vital, and prehospital enrollment may be associated with higher rates of subject withdrawal than more traditional methods of enrollment. Objective: To describe rates of subject retention in a prehospital trial of acute stroke therapy and to determine if method of consent was associated with subject withdrawal. Methods: All subjects were enrolled in the NIH Field Administration of Stroke Therapy-Magnesium (FAST-MAG) clinical trial. Paramedics screen eligible subjects, contact the physician-investigator using dedicated in-ambulance cellular phone. Physician-investigators obtain explicit informed consent from the subject or on-scene LAR. In the later years of study, enrolment under exception from informed consent (EFIC) was permitted. The consent provider was given a consent form, which they reviewed with the physician investigator on the phone and signed prior to study initiation. Retention, defined as study subject completion without withdrawal. Results: There were 1700 subjects enrolled; 1,017 provided consent (60%), 662 enrolled via LAR (39%) and 21 via EFIC (1%). Of 1,700 patients, 1413 (83%) completed the 90-day cvisit, 265 (16%) died prior to the 90-day visit and 22 (1.3%) withdrew from the study before completion. Of the 22 cases what withdrew, 11 were lost to follow-up, 11 had the patient or LAR withdraw consent. There were no differences in rates of withdrawal by method of study enrolment: Self consent (n=14) 1.4%, LAR (n=8) 1.2%, EFIC (n=0) 0%. Potential factors related to higher rates of withdrawal were evaluated including language of consent (Spanish 4/165, 2.1%, English 18/1248, 1.2%), but none were significant. The most common reason for withdrawal of consent was family objection to continued participation in research. Conclusion: There was a high rate of retention when subjects were enrolled into prehospital stroke research using a phone-based method to obtain explicit consent. We were not able to identify factors associated with study withdrawal, likely due to high retention.

Published
2017
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25. F8 gene dosage defects in atypical patients with severe haemophilia A

Author

J Rosell, Eduardo F. Tizzano, A. Villar, R. P. Garrido, F. Velasco, R. Núñez, Víctor Jiménez-Yuste, Montserrat Baiget, M. Baena, and A. Venceslá

Subjects
business.industry, Molecular pathology, Haemophilia A, Hematology, General Medicine, Bioinformatics, medicine.disease, Gene dosage, Exon, Gene duplication, medicine, Multiplex ligation-dependent probe amplification, Klinefelter syndrome, Allele, business, Genetics (clinical)
Abstract

Summary. We performed molecular analysis of the factor 8 gene (F8) in 272 unrelated Spanish patients with haemophilia A (HA) and detected a mutation by routine analysis in 267 of them (98.1%). No mutation was detected in the remaining five patients despite clinical and laboratory confirmation of HA. The aim is to describe the molecular alterations in F8 discovered by gene dosage methodologies in three of these patients. For methodology, F8 sequencing, intragenic marker analysis, multiplex ligation-dependent probe amplification and quantitative real time-PCR were followed. One patient had Klinefelter syndrome (47,XXY) and a large deletion spanning exons 1–12 masked by the other F8 allele; the second patient showed a large duplication spanning exons 2–10 and the third patient revealed a non-contiguous double duplication of exons 14 and 23–25. The remaining two patients had mild HA and dosage results were normal. The application of gene dosage methods is useful to define haemophilic patients in whom mutations are not detected using other routine methods. Nevertheless, in a small percentage of patients (

Published
2012
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27. Frecuencia y características de las cartas al director publicadas en Farmacia Hospitalaria (1995-2006)

Author

M. Lacasaña Navarro and J. Rosell Pradas

Subjects
Pharmacology, History, Letter to the editor, Health professionals, Publishing, business.industry, Hospital doctor, Library science, Hospital pharmacy, business
Abstract

OBJECTIVE To describe the frequency and bibliographical characteristics of letters to the editor published in the Farmacia Hospitalaria journal (hospital pharmacy) between 1995 and 2006. METHOD Descriptive and comprehensive study on documents classified as letters to the editor, which were published between 1995 and 2006. Using journal issues as a source, the following variables were identified: number of letters/year, main content, text length (words), language, use of graphs, number of authors and their professional experience, number of participating institutions, origin in terms of autonomous community, number of bibliographical references and their origin. Descriptive statistics were used. RESULTS A total of 82 letters were identified, with a mean of 7 per year and 1.1 per journal. They were more frequent during the last two years, 43 (52%) of the total, following their practical non-existence between 1998 and 2003. The majority of the letters, 52 (63%), were regarding clinical cases while 23 (28%) were related to publications or were replies to the letters themselves. All letters met the requirements regarding text length, language and use of graphs. The mean number of authors was 3, and in 12 letters (14%) the limit on the number of authors was exceeded. In 56 cases (64%), the letters were written by hospital pharmacists only, however 26 (32%) were written in conjunction with hospital doctors. In 16 of the letters (20%), the authors belonged to one or more institutions. The letters mainly came from Valencia, Catalonia, Madrid and Andalusia. A total of 411 supporting references were gathered. The mean was 5 citations per letter to the editor, between 0 and 15 references, and in 17 cases (21%), the number of references was higher than the accepted limit. Of the total citations, 255 (60%) were from foreign publications. CONCLUSIONS Letters to the editor in Farmacia Hospitalaria significantly increased during the last two years of the period studied and were practically non-existent before this. It is worth noting that many of the letters were written in collaboration with other health professionals and with the support of a number of institutions. It is compulsory that the letters meet publishing requirements, with the exception of a number of authors and references which were published without being thoroughly checked beforehand.

Published
2007
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28. Encephalitozoon hellem infection in aviary passerine and psittacine birds in Spain

Author

Elizabeth S. Didier, J. Rosell, Carles Juan-Sallés, Lisa C. Bowers, M. Máinez, and Alberto Marco

Subjects
0301 basic medicine, Male, Canaries, Agapornis roseicollis, Zoology, Mycology & Parasitology, Carduelis carduelis, Microsporidiosis, Microbiology, Agapornis, Article, 03 medical and health sciences, biology.animal, Serinus canaria, medicine, Animals, Veterinary Sciences, Apical cytoplasm, General Veterinary, biology, Bird Diseases, Carduelis, Encephalitozoon, General Medicine, 030108 mycology & parasitology, biology.organism_classification, medicine.disease, Fisheries Sciences, Encephalitozoonosis, Intestines, Spain, Feather, visual_art, visual_art.visual_art_medium, Parasitology, Female, Finches, Nested polymerase chain reaction
Abstract

A European goldfinch (Carduelis carduelis), a canary (Serinus canaria), and a lovebird (Agapornis roseicollis) captive-bred at three different private aviaries in Spain were submitted for necropsy with a history of weakness and ruffled feathers, weight loss associated with glossitis, and respiratory disease, respectively. Microscopically, enterocytes in the jejunum and ileum contained colonies of gram- and Stamp-positive, oval to elliptical microorganisms within parasitophorous vacuoles in the apical cytoplasm. Nested PCR using MSP primers that target microsporidian RNA genes produced amplicons of expected size for Encephalitozoon species, and analysis of forward and reverse DNA sequences confirmed the presence of Encephalitozoon hellem in all cases. The main cause of death of all three birds consisted of concurrent infections. However, intestinal encephalitozoonosis may have contributed to exacerbated catabolism. Encephalitozoonosis (or microsporidiosis) has been rarely described in passerine birds.

Published
2015

29. Diagnóstico prenatal de 2 casos de arco aórtico derecho

Author

J. Grau, J. Castilla, A. Tubau, D. Heine, J. Rosell, M. I. Hernandez, M. Juan, and M. A. Ferragut

Subjects
Obstetrics and Gynecology
Abstract

Resumen Las anomalias del arco aortico derecho se adscriben a un grupo de malformaciones poco frecuentes y escasamente descritas en la bibliografia en su forma prenatal; sin embargo, no es infrecuente hallarlas como causa de patologia respiratoria o digestiva (refractarias a tratamiento) en pacientes adultos e incluso como procesos vasculares severos con morbimortalidad elevada. La relacion de los grandes vasos con la traquea en el mediastino alto, en el estudio fetal, permite un diagnostico relativamente sencillo, cuando se contempla su posibilidad diagnostica.

Published
2005
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30. Our experience in the evaluation criteria used for the genetic study of patients suspected of being affected by multiple endocrine neoplasia type 1 and mutational spectrum

Author

Josefina Biarnés, Immaculada Recas, Albert Lecube, Albert Goday, Manel Puig-Domingo, Irene Halperin, Eduarda Pizarro, Lourdes Loidi, Josep Oriola, Carles Villabona, J Rosell, S. Martínez, F Sanchez-Garcia, José Manuel Gómez, E Gonzalez-Romero, Rafael Simó, Antoni Sitges, Juan Garcia-Arnes, Jordi Mesa, and Isabel Salinas

Subjects
Gynecology, medicine.medical_specialty, business.industry, medicine, Multiple endocrine neoplasia, medicine.disease, business
Abstract

Gonzalez-Romero7, J. A. Garcia-Arnes7, A. Lecube8, J. Mesa9, R. Simo9, J. Rosell10, F. Sanchez-Garcia11, I. Recas12, F. Biarnes12, E. Pizarro13, I. Halperin1. 1 Bioquimica y Genetica Molecular, Endocrinologia, H. Clinic de Barcelona; 2 Cirugia, Endocrinologia, H. del Mar, Barcelona; 3 Endocrinologia, H. General Universitario Elda, Alicante; 4 Endocrinologia, H. de Bellvitge, Barcelona, 5Medicina Molecular, S. de Compostela; 6 Endocrinologia, H. Germans Trias Pujol, Badalona; 7Endocrinologia, H. Provincial de Malaga; 8H.Arnau de Vilanova, Lleida; 9H. Vall d’Hebron,Barcelona; 10Genetica, H.Son Espasses, P.Mallorca; 11Inmunologia, H.Dr. Negrin,Gran Canaria;12 Endocrinologia, H.J.Trueta, Girona; 13Endocrinologia, H.de Mataro. OUR EXPERIENCE IN THE EVALUATION CRITERIA USED FOR THE GENETIC STUDY OF PATIENTS SUSPECTED OF BEING AFFECTED BY MULTIPLE ENDOCRINE NEOPLASIA TYPE1 AND MUTATIONAL SPECTRUM

Published
2014
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31. Exactitud de las estadísticas de mortalidad por causas externas y naturales con intervención médico-legal en Cataluña, 1996

Author

Glòria Pérez, P. Molina, M. de Aran Bares, and J. Rosell

Subjects
Exactitud, Injury control, Accident prevention, Philosophy, Death certificates, Certificados de defunción, Public Health, Environmental and Occupational Health, Poison control, External cause of death, Autopsia, Estadísticas vitales, Mortalidad, Autopsy, Mortality, Humanities, Causa de muerte externa, Vital statistics, Accuracy
Abstract

ResumenObjetivoLas muertes por causas externas y naturales con intervención judicial requieren autopsia médico-legal. Para formar parte de las estadísticas de mortalidad, los resultados de las autopsias se declaran en el documento estadístico MNP52. La exactitud de las causas de muerte declaradas en este documento podría depender de la persona que lo cumplimenta (médico-forense y personal del juzgado), del momento en que se hace (después de la muerte o de la autopsia) y de la estructura del mismo. El objetivo es conocer con qué exactitud se notifican las causas de muerte en las defunciones con intervención judicial de Cataluña en 1996.MétodosSe realizaron dos muestreos: uno para causas naturales y otro para causas externas; se estratificó por sexo y partido judicial. Las fuentes de información fueron el Registro de Mortalidad de Cataluña para los documentos estadísticos y los Juzgados de Instrucción para los informes de autopsia médico-legal, de toxicología y de anatomía patológica. Se calculó la concordancia global simple, la sensibilidad o tasa de detección (TD) y el valor predictivo positivo o tasa de confirmación (TC) con sus respectivos intervalos de confianza.ResultadosLa concordancia global simple fue de 72,3% (IC 95%: 68,7-75,9). Para los grupos de causas externas la TD fue de 65,9% (60,6-71,2) y la TC de 69% (63,6-71,2). Para los grupos de causas naturales la TD resultó 79,4% (74,7-84,2) y la TC 75,5% (70,7-80,5).ConclusionesEn las defunciones con intervención judicial, los documentos estadísticos oficiales carecen de exactitud en la notificación de las causas externas; en las causas naturales se aproximan al grado de exactitud que se considera aceptable. Estos resultados son debidos principalmente a déficits en la cumplimentación e incorrecta certificación de causas de muerte en los documentos estadísticos oficiales.SummaryObjectiveDeaths due to external and natural causes with forensic intervention require medical-legal autopsy. In order to be included in the mortality statistics the results are reported in the statistical document MNP52. The accuracy of cause of death depends on the characteristics of the document, the point at which it is completed (after the death or after the autopsy) and the person that completes it.The objective is to determine the accuracy of external and natural causes of death with forensic intervention, reported in the official statistical documents by a medical-legal autopsy report of these deaths occurred in Catalonia in 1996.MethodsTwo samplings were undertaken —one for natural causes and another for external causes— that were stratified by sex and judicial district. The information sources were the Mortality Register of Catalonia for the statistical documents and the criminal courts for the medical-legal autopsy, toxicological and pathological reports. We calculated the index of agreement, the sensitivity or detection rate (DR) and the positive predictive value or confirmation rate (CR), and their respective 95% confidence intervals.ResultsThe index of agreement was 72,3% (IC 95%: 68,7-75,9). The DR for external causes groups was 65,9% (60,6-71,2) and the CR was 69% (63,6-71,2). For natural causes the DR was 79,4% (74,7-84,2) and the CR was 75,5% (70,7-80,5).ConclusionIn deaths with forensic intervention, the official statistical documents do not correctly report external causes of death, and statistics for natural causes of death approach acceptable levels of accuracy. The results are mainly due to deficits in reporting and certifying these causes in the official statistics.

Published
2000
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32. La medida del dolor causado durante la inmunización rutinaria. Validez convergente de cuatro indicadores de dolor

Author

J. Rosell Barberà, L. González Trapote, M. Artés Ferragud, F. Prandi Farràs, S. Herranz del Rey, J. Guerrero Bellostas, J. Freixas Benavides, J.M. Cervera Luque, A. Fernández Matamoros, and X. Bruna Pérez

Subjects
Infectious Diseases, Immunology
Abstract

Fundamento Establecer la fiabilidad y validez de cuatro indicadores de dolor en un estudio con ninos que reciben una vacuna inyectable. Metodos Estudio observacional, multicentrico y prospectivo con 76 ninos (de 4 a 52 meses de edad). El dolor causado por dicha vacuna fue medido mediante los cambios observados en el pulso, una escala conductual traduccion de la "Modified Behavioural Pain Scale (MBPS)" y dos escalas visuales analogicas (EVA) puntuadas por un observador independiente y por el padre acompanante, respectivamente. Se evaluo la fiabilidad y validez de los indicadores de dolor utilizados mediante correlaciones item-test, coeficiente alfa de Cronbach, correlaciones de Pearson y analisis factorial confirmatorio. La influencia del sexo, la edad, la localizacion de la puncion y el tipo de vacuna se evaluo mediante un modelo de regresion lineal. Resultados La escala conductual MBPS tuvo una fiabilidad de consistencia interna adecuada (alfa de Cronbach entre 0,86 y 0,91) y una correlacion de 0,56 con el cambio en el pulso (p Conclusiones Las EVA evaluadas por observadores miden aspectos del dolor distintos de los que miden indicadores fisiologicos o conductuales. La escala MBPS parece ser el mejor indicador de dolor en el contexto de este estudio.

Published
2000
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33. New interpretation of the Gran Dolina-TD6 bearing Homo antecessor deposits through sedimentological analysis

Author

Autoecologia Humana del Quaternari, Història i Història de l'Art, Universitat Rovira i Virgili, J. Rosell; I. Campaña; A. Pérez-González; A. Benito-Calvo; R. Blasco; J. M. Bermúdez de Castro; E. Carbonell; J. L. Arsuaga, Autoecologia Humana del Quaternari, Història i Història de l'Art, Universitat Rovira i Virgili, and J. Rosell; I. Campaña; A. Pérez-González; A. Benito-Calvo; R. Blasco; J. M. Bermúdez de Castro; E. Carbonell; J. L. Arsuaga

Abstract

DOI: 10.1038/srep34799 URL: http://www.nature.com/articles/srep34799 Filiació URV: SI Inclòs a la memòria: SI, Gran Dolina is a cavity infilled by at least 25 m of Pleistocene sediments. This sequence contains the TD6 stratigraphic unit, whose records include around 170 hominin bones that have allowed the definition of a new species, Homo antecessor. This fossil accumulation was studied as a single assemblage and interpreted as a succession of several human home bases. We propose a complete stratigraphic context and sedimentological interpretation for TD6, analyzing the relationships between the sedimentary facies, the clasts and archaeo-palaeontological remains. The TD6 unit has been divided into three sub-units and 13 layers. Nine sedimentary facies have been defined. Hominin remains appear related to three different sedimentary facies: debris flow facies, channel facies and floodplain facies. They show three kinds of distribution: first a group of scattered fossils, then a group with layers of fossils in fluvial facies, and third a group with a layer of fossils in mixed fluvial and gravity flow facies. The results of this work suggest that some of these hominin remains accumulated in the cave by geological processes, coming from the adjacent slope above the cave or the cave entry, as the palaeogeography and sedimentary characteristics of these allochthonous facies suggest.

Published
2016

34. Magnetic Induction-Based Sensor for Vital Sign Detection

Author

J. Rosell-Ferrer and Hadiseh Mahdavi

Subjects
Data acquisition, Computer science, Electromagnetic coil, Acoustics, Continuous monitoring, Phase angle, Breathing, Signal, Low-noise amplifier, Electromagnetic induction
Abstract

Nowadays, various medical applications demand for less-obtrusive and continuous respiratory and cardiac activity monitoring methods. Sleep monitoring and home health care are some examples of these applications. Magnetic induction could provide such a contactless unobtrusive method for continuous monitoring of vital signs. In this paper, we present the preliminary results of a developed magnetic induction sensor. The system consists of one coil for excitation and a specific shaped coil for detection. For data acquisition we have used a low noise amplifier plus a phase sensitive detection circuit. The measured phase angle and magnitude are acquired simultaneously with cardiac and respiratory signals from standard sensors of a BIOPAC system. Considering the objective of having a system to be integrated in the bed, the coils were designed in a printed circuit board (PCB). Supine and prone positions, apnea and breathing periods were parts of the experiments to investigate different parameters which affect the signal. Comparing the breathing and apnea periods, respiration and heart activity is clearly reflected in the detected signal and the results show that the system could detect these vital signs.

Published
2014
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35. Septicaemia Caused by Citrobacter braakii Infection in a Captive Nile Crocodile (Crocodylus niloticus)

Author

Joaquín Ortega, M. Casares, J. Rosell, A Barragán, M. D. Carbonell, J.M. Corpa, D. Viana, L. Selva, A. C. Gerique, and M. Fernández

Subjects
0301 basic medicine, General Veterinary, Nile crocodile, biology, Zoology, Citrobacter braakii, 04 agricultural and veterinary sciences, biology.organism_classification, Crocodylus, Pathology and Forensic Medicine, 03 medical and health sciences, 030104 developmental biology, biology.animal, 040102 fisheries, 0401 agriculture, forestry, and fisheries
Published
2017
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36. F8 gene dosage defects in atypical patients with severe haemophilia A

Author

Á, Venceslá, M, Baena, R P, Garrido, R, Núñez, F, Velasco, J, Rosell, A, Villar, V, Jiménez-Yuste, M, Baiget, and E F, Tizzano

Subjects
Adult, Aged, 80 and over, Male, Factor VIII, Adolescent, DNA Mutational Analysis, Gene Dosage, Exons, Hemophilia A, Pedigree, Klinefelter Syndrome, Spain, Gene Duplication, Humans, Child, Multiplex Polymerase Chain Reaction, Aged, Sequence Deletion
Abstract

We performed molecular analysis of the factor 8 gene (F8) in 272 unrelated Spanish patients with haemophilia A (HA) and detected a mutation by routine analysis in 267 of them (98.1%). No mutation was detected in the remaining five patients despite clinical and laboratory confirmation of HA. The aim is to describe the molecular alterations in F8 discovered by gene dosage methodologies in three of these patients. For methodology, F8 sequencing, intragenic marker analysis, multiplex ligation-dependent probe amplification and quantitative real time-PCR were followed. One patient had Klinefelter syndrome (47,XXY) and a large deletion spanning exons 1-12 masked by the other F8 allele; the second patient showed a large duplication spanning exons 2-10 and the third patient revealed a non-contiguous double duplication of exons 14 and 23-25. The remaining two patients had mild HA and dosage results were normal. The application of gene dosage methods is useful to define haemophilic patients in whom mutations are not detected using other routine methods. Nevertheless, in a small percentage of patients (1%), no molecular pathology can be identified after testing several genetic methodologies.

Published
2012

37. Electrical stimulation of cardiac adipose tissue-derived progenitor cells modulates cell phenotype and genetic machinery

Author

A, Llucià-Valldeperas, B, Sanchez, C, Soler-Botija, C, Gálvez-Montón, C, Prat-Vidal, S, Roura, J, Rosell-Ferrer, R, Bragos, and A, Bayes-Genis

Subjects
Ions, Tissue Engineering, Phalloidine, Myocardium, Stem Cells, Biocompatible Materials, Cell Differentiation, Electric Stimulation Therapy, Real-Time Polymerase Chain Reaction, Up-Regulation, Phenotype, Adipose Tissue, Microscopy, Fluorescence, Humans, Regeneration, Myocytes, Cardiac, Cells, Cultured, Signal Transduction
Abstract

A major challenge of cardiac tissue engineering is directing cells to establish the physiological structure and function of the myocardium being replaced. Our aim was to examine the effect of electrical stimulation on the cardiodifferentiation potential of cardiac adipose tissue-derived progenitor cells (cardiac ATDPCs). Three different electrical stimulation protocols were tested; the selected protocol consisted of 2 ms monophasic square-wave pulses of 50 mV/cm at 1 Hz over 14 days. Cardiac and subcutaneous ATDPCs were grown on biocompatible patterned surfaces. Cardiomyogenic differentiation was examined by real-time PCR and immunocytofluorescence. In cardiac ATDPCs, MEF2A and GATA-4 were significantly upregulated at day 14 after stimulation, while subcutaneous ATDPCs only exhibited increased Cx43 expression. In response to electrical stimulation, cardiac ATDPCs elongated, and both cardiac and subcutaneous ATDPCs became aligned following the linear surface pattern of the construct. Cardiac ATDPC length increased by 11.3%, while subcutaneous ATDPC length diminished by 11.2% (p = 0.013 and p = 0.030 vs unstimulated controls, respectively). Compared to controls, electrostimulated cells became aligned better to the patterned surfaces when the pattern was perpendicular to the electric field (89.71 ± 28.47º for cardiac ATDPCs and 92.15 ± 15.21º for subcutaneous ATDPCs). Electrical stimulation of cardiac ATDPCs caused changes in cell phenotype and genetic machinery, making them more suitable for cardiac regeneration approaches. Thus, it seems advisable to use electrical cell training before delivery as a cell suspension or within engineered tissue.

Published
2012

38. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain

Author

H. Hattig, C. Delli Pizzi, M. C. Addonizio, Michelle Davis, A. R. Giovagnoli, L. Florensa, M. Roth, J. de Kruijk, Francisco Lacruz, Ph. Dewailly, A. Toygar, C. Avendano, P.P. De Deyn, J. F. Hurtevent, F. Lomeila, T. W. Wong, Gordon T. Plant, M. Bud, H. J. Willison, DH Miller, D. W. Langdon, R. Cioni, J. Servan, A. Kaygisiz, E. Racadot, D. B. Schens, E. Picciola, L. Falip, C. Bouchard, J. Jotova, A. Jorge-Santamaria, P. Misra, A. Dufour, C. P. Panagopoulos, A. Venneri, B. Sredni, B. Angelard, M. Janelidze, M. Carreno, J. Obenberger, J. Pouget, H. W. Moser, R. Kaufmann, J. A. Molina, D. Linden, A. Martin Urda, E. Uvestad, A. Krone, J. P. Cochin, J. Mallecourt, A. Cambon-Thomsen, K. Violleau, P. Osschmann, A. M. Durocher, E. Bussaglia, D. M. Danielle, H. Efendi, C. Van Broeckhoven, K. G. Jordan, W. Rautenberg, C. Iniguez, J. M. Delgado, Graham Watson, M. Lawden, Gareth J. Barker, K. Stiasny, James T. Becker, G. Campanella, E. Peghi, A. Poli, A. Haddad, T. Yamawaki, Giacomo P. Comi, S. Sotgiu, B. Ersmark, A. Pomes, M. Ziegler, P. Ferrante, P. Ruppi, H. KuÇukoglu, R. Bouton, U. K. Rinne, P. Vieregge, M. Dary, P. Giunti, Peter J. Goadsby, S. Jung, E. Secor, A. Steinberg, N. Vila, M. A. Hernandez, M. Cursi, A. Enqelhardt, A. Engelhardt, J. Veitch, F. Di Silverio, F. Arnaud, B. Neundörfer, R. Brucher, Dominique Caparros-Lefebvre, B. Meyer, Marianne Dieterich, M. H. Snidaro, R. Gomez, R. Cerbo, M. Ragno, J. M. Vance, S. Nemni, A. Caliskan, F. Barros, I. Velcheva, D. Ceballos-Baumann, V. Barak, A. Avila, N. Antonova, F. Resche, S. Pappata, L. Varela, S. R. Silveira Santos, A. Cammarota, L. Naccache, Y. Nara, E. Tournier-Lasserves, R. Mobner, T. Chase, A. Ensenyat, J. Ulrich, G. Giegerich, M. Rother, M. Revilla, N. Nitschke, K. Honczarenko, E. Basart Tarrats, J. Blin, B. Jacob, J. Santamaria, S. Knezevic, J. L. Castillo, M. Antem, J. Colomer, O. Busse, Didier Hannequin, S. Carrier, J. B. Ruidavets, C. Rozman, J. Bogoussslavsky, J. Pascual Calvet, E. Monros, J. M. Polo, M. Zucconl, Javier Muruzabal, R. R. Allen, R. Rivolta, K. Haugaard, A. Nespolo, K. Hoang-Xuang, G. Bussone, T. Avramidis, E. Corsini, Christiana Franke, T. Vinogradova, H. Boot, K. Vestergaard, G. H. Jansen, N. Argentino, M. Raltzig, W. Linssen, Mark B. Pepys, P. Roblot, L. Lauritzen, E. Fainardi, D. Morin, T. X. Arbizu Urdiain, J. Wollenhaupt, S. Bostantjopoulou, G. Pavesi, A. D. Forman, Giovanni Fabbrini, D. Jean, J. J. Archelos, M. I. Blanchs, M. Del Gobbo, Anna Carla Turconi, Ch. Derouesné, Elio Scarpini, A. Visbeck, P. Castejon, J. P. Renou, F. Mounier-Vehier, G. Potagas, Ch. Duyckaerts, A. Filla, R. Schneider, G. Ronen, K. Nagata, J. P. Vedel, A. Henneberg, G. van Melle, C. Baratti, H. Knott, M. C. Prevett, A. Bes, B. Metin, Jos V. Reempts, L. Martorell, Mefkure Eraksoy, H. O. Handwerker, D. S. Younger, O. Oktem, D. Frongillo, C. Soriano-Soriano, L. Niehaus, F. Zipp, A. Tartaro, S Newman, R. H. Browne, P. Davous, R. Sanchez, M. Muros, M. E. Kornhuber, A. Lavarone, M. Mohr, M. R. 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Masana, A. Goossens, B. Heye, K. Lauer, Heinz Gregor Wieser, Stephen R. Williams, B. Garavaglia, A. P. Sempere, F. Grigoletto, P. Poindron, R. Lopez-Pajares, I. Leite, T. A. McNell, C. Caucheteur, J. M. Giron, A. D. Collins, P. Freger, J. Sanhez Del Rio, D. A. Harn, K. Lindner, S. S. Scherer, G. Serve, M. Juncadella, X. Estivill, R. Binkhorst, M. Anderson, B. Tekinsoy, C. Sagan, T. Anastopoulos, G. Japaridze, S. Guillou, F. Erminio, Jon Sussman, P. G. Oomes, D. S. Rust, S. Mascheroni, O. Berger, M. Peresson, K. V. Toyka, T. W. Polder, M. Huberman, B. Arpaci, H. Ramtami, I. Martinez, Ph. Violon, P. P. Gazzaniga Pozzill, R. Ruda, P. Auzou, J. Parker, S. P. Morrissey, Jiahong Zhu, F. Rotondi, P. Baron, W. Schmid, P. Doneda, M. Spadaro, M. C. Nargeot, I. Banchs, J.S.P. van den Berg, R. Ferrai, M. Robotti, M. Fredj, Pedro M. Rodríguez Cruz, B. Erne, D. G. Piepgras, M. C. Arne-Bes, J. Escudero, C. Goetz, A. R. Naylor, M. Hallett, O. Abramsky, E. Bonifacio, L. E. Larsson, R. Pellikka, P. Valalentino, D. Guidetti, B. Buchwald, C. H. Lücking, D. Gauvreau, F. Pfaff, A. Ben Younes-Chennoufi, R. Kiefer, R. Massot, K. A. Hossmann, L. Werdelin, P. J. Baxter, U. Ziflo, S. Allaria, C. D. Marsden, M. Cabaret, S. P. Mueller, E. Calabrese, R. Colao, S. I. Bekkelund, M. Yilmaz, O. Oktem-Tanor, R. Gine, M. E. Scheulen, J. Beuuer, A. Melo, Z. Gulay, M. D. Have, C. Frith, D. Liberati, J. Gozlan, P. Rondot, Ch. Brunholzl, M. Pocchiari, J. Pena, L. Moiola, C. Salvadori, A. Cabello, T. Catarci, S. Webb, C. Dettmers, N. A. Gregson, Alexandra Durr, F. Iglesias, U. Knorr, L. Ferrini-Strambi, F. Kruggel, P. Allard, A. Coquerel, P. Genet, F. Vinuels, C. Oberwittler, A. Torbicki, P. Leffers, B. Renault, B. Fauser, C. Ciano, G. Uziel, J. M. Gibson, F. Anaya, C. Derouesné, C. N. Anagnostou, M. Kaido, W. Eickhoff, G. Talerico, M. L. Berthier, A. Capdevila, M. Alons, D. Rezek, E. Wondrusch, U. Kauerz, D. Mateo, M. A. Chornet, Holon, N. Pinsard, I. Doganer, E. Paoino, H. Strenge, C. Diaz, J. R. Brasic, W. Heide, I. Santilli, W. M. Korn, D. Selcuki, M. J. Barrett, D. Krieger, T. Leon, T. Houallah, M. Tournilhac, C. Nos, D. Chavot, F. Barbieri, F. J. Jimenez-Jimenez, J. Muruzabal, K. Poeck, A. Sennlaub, L. M. Iriarte, L. G. Lazzarino, C. Sanz, P. A. Fischer, S. D. Shorvon, R. Hoermann, F. Delecluse, M. Krams, O. Corabianu, F. H. Hochberg, Christopher J. Mathias, B. Debachy, C. M. Poser, L. Delodovici, A. Jimenez-Escrig, F. Baruzzi, F. Godenberg, D. Cucinotta, P. J. Garcia Ruiz, K. Maier-Hauff, P. R. Bar, R. Mezt, R. Jochens, S. Karakaneva, C. Roberti, E. Caballero, Joseph E. Parisi, M. Zamboni, T. Lacasa, B. Baklan, J. C. Gautier, J. A. Martinez-Matos, W. Pollmann, G. Thomas, L. Verze, E. Chleide, R. Alvarez Sala, I. Noel, E. Albuisson, O. Kastrup, S. I. Rapoport, H. J. Braune, H. Lörler, M. Le Merrer, A. Biraben, S. Soler, S. J. Taagholt, U. Meyding-Lamadé, K. Bleasdale-Barr, Isabella Moroni, Y. Campos, J. Matias-Guiu, G. Edan, M. G. Bousser, John B. Clark, J. Garcia de Yebenes, N. K. Olsen, P. Hitzenberger, S. Einius, Aj Thompson, Ch. J. Vecht, T. Crepin-Leblond, Klaus L. Leenders, A. Di Muzio, L. Georgieva, René Spiegel, K. Sabey, D. Ménégalli, J. Meulstee, U. Liszka, P. Giral, C. Sunol, J. M. Espadaler, A. D. Crockar, K. Varli, G. Giraud, P. J. Hülser, A. Benazzouz, A. Reggio, M. Salvatore, K. Genc, M. Kushnir, S. Barbieri, J. Ph. Azulay, M. Gianelli, N. Bathien, A. AlMemar, F. Hentati, I. Ragueneau, F. Chiarotti, R. C. F. Smits, A. K. Asbury, F. Lacruz, B. Muller, Alan J. Thompson, Gordon Smith, K. Schmidt, C. Daems Monpeun, Juergen Weber, A. Arboix, G. R. Fink, A. M. Cobo, M. Ait Kaci Ahmed, E. Gencheva, Israel-Biet, G. Schlaug, P. De Jonghe, Philip Scheltens, K. Toyka, P. Gonzalez-Porque, A. Cila, J. M. Fernandez, P. Augustin, J. Siclia, S. Medaglini, D. E. Ziogas, A. Feve, L. Kater, G. J. E. Rinkel, D. Leppert, Rüdiger J. Seitz, S. Ried, C. Turc-Carel, G. Smeyers, F. Godinho, M. Czygan, M. Rijntjes, E. Aversa, M. Frigo, Leif Østergaard, J. L. Munoz Blanco, A. Cruz-Matinez, J. De Reuck, C. Theillet, T. Barroso, V. Oikonen, Florence Lebert, M. Kilinc, C. Cordon-Cardon, G. Stoll, E. Thiery, F. Pulcinelli, J. Solski, M. Schmiegelow, L. J. Polman, P. Fernandez-Calle, C. Wikkelso, M. Ben Hamida, M. Laska, E. Kott, W. Sulkowski, C. Lucas, N. M. Bornstein, D. Schmitz, M. W. Lammers, A. de Louw, R. J. S. Wise, P. A. van Darn, C. Antozzi, P. Villanueva, P. H. E. Hilkens, C. Constantin, W. Ricart, A. Wolf, M. Gamba, P. Maguire, Alessandro Padovani, B. M. Patten, Marie Sarazin, H. Ackermann, L. Durelli, S. Timsit, Sebastian Jander, B. W. Scheithauer, G. Demir, J. P. Neau, P. Barbanti, A. Brand, N. AraÇ, V. Fischer-Gagnepain, R. Marchioli, G. Serratrice, C. Maugard-Louboutin, G. T. Spencer, D. Lücke, G. Mainardi, K. Harmant Van Rijckevorsel, G. B. Creel, R. Manzanares, Francesco Fortunato, A. May, J. Workman, K. Johkura, E. Fernandez, Carlo Colosimo, L. Calliauw, L. Bet, Félix F. Cruz-Sánchez, M. Dhib, H. Meinardi, F. Carrara, J. Kuehnen, C. Peiro, H. Lassmann, K. Skovgaard Olsen, A. McDonald, L. Sciulli, A. Cobo, A. Monticelli, B. Conrad, J. Bagunya, J. Benitez, V. Desnizza, B. Dupont, O. Delrieu, D. Moraes, J. J. Heimans, F. Garcia Rio, M. Matsumto, A. Fernandez, R. Nermni, R. Chalmers, M. J. Marchau, F. Aguado, P. Velupillai, P. J. Martin, P. Tassan, V. Demarin, A. Engelien, T. Gerriets, Comar, J. L. Carrasco, J. P. Pruvo, A. Lopez de Munain, D. Pavitt, J. Alarcon, Chris H. Polman, B. Guldin, N. Yeni, Hartmut Brückmann, N. Wilczak, H. Szwed, R. Causaran, G. Kyriazis, M. E. Westarp, M. Gasparini, N. Pecora, J. M. Roda, E. Lang, V. Scaioli, David R. Fish, D. Caputo, O. Gratzl, R. Mercelis, A. Perretti, G. Steimetz, I. Link, C. Rigoletto, A. Catafau, G. Lucotte, M. Buti, G. Fagiolari, A. Piqueras, C. Godinot, J. C. Meurice, Erodriguez J. Dominigo, F. Lionnet, H. Grzelec, David J. Brooks, P. M. G. Munro, F. X. Weilbach, M. Maiwald, W. Split, B. Widjaja-Cramer, V. Ozturk, J. Colas, E. Brizioli, J. Calleja, L. Publio, M. Desi, R. Soffietti, P. Cortinovis-Tourniaire, E. F. Gonano, G. Cavaletti, S. Uselli, K. Westerlind, H. Betuel, C. O. Dhiver, H. Guggenheim, M. Hamon, R. Fazio, P. Lehikoinen, A. Esser, B. Sadzot, G. Fink, Angelo Antonini, D. Bendahan, V. Di Carlo, G. Galardi, A. F. Boller, M. Aksenova, Del Fiore, V. de la Sayette, H. Chabriat, A. Nicoletti, A. Dilouya, M. L. Harpin, E. Rouillet, J. Stam, A. Wolters, M. R. Delgado, Eduardo Tolosa, G. Said, A. J. Lees, L. Rinaldi, A. Schulze-Bonhage, MA Ron, C. Lefebvre, E. W. Radü, R. Alvarez, M. L. Bots, P. Reganati, S. Palazzi, A. Poggi, N. J. Scolding, V. Sazdovitch, T. Moreau, E. Maes, M. A. Estelies, P. Petkova, Jose-Felix Marti-Masso, G De La Meilleure, N. Mullatti, M. Rodegher, N. C. Notermans, T. A. T. Warner, S. Aktan, J. P. Louboutin, L. Volpe, C. Scheidt, W. Aust, C. M. Wiles, U. Schneider, S. K. Braekken, W. R. Willems, K. Usuku, Peter M. Rothwell, C. Talamon, M. L. Sacchetti, A. Codina, M. H. Marion, A. Santoro, J. Roda, A. Bordoni, D. J. Taylor, S. Ertas, H. H. Emmen, J. Vichez, V. BesanÇon, R. E. Passingham, M. L. Malosio, A. Vérier, M. Bamberg, A. W. Hansen, E. Mostacero, G. Gaudriault, Marie Vidailhet, B. Birebent, K. Strijckmans, F. Giannini, T. Kammer, I. Araujo, J. Nowicki, E. Nikolov, A. Hutzelmann, R. Gherardi, J. Verroust, L. Austoni, A. Scheller, A. Vazquez, S. Matheron, H. Holthausen, J. M. Gerard, M. Bataillard, S. Dethy, V. H. Patterson, V. Ivanez, N. P. Hirsch, F. Ozer, M. Sutter, C. Jacomet, M. Mora, Bruno Colombo, A. Sarropoulos, T. H. Papapetropoulos, M. Schwarz, D. S. Dinner, N. Acarin, B. Iandolo, J. O. Riis, P. R. J. Barnes, F. Taroni, J. Kazenwadel, L. Torre, A. Lugaresi, I. L. Henriques, S. Pauli, S. Alfonso, Pedro Quesada, A. S. T. Planting, J. M. Castilla, Thomas Gasser, M. Van der Linden, A. Alfaro, E. Nobile-Orazio, G. Popova, W. Vaalburg, F. G. A. van der Mech, L. Williams, F. Medina, J. P. Vernant, J. Yaouanq, B. Storch-Hagenlocher, A. Potemkowski, R. Riva, M. H. Mahagne, M. Ozturk, Ve. Drory, N. Konic, C. Jungreis, A. Pou Serradell, J. L. Gauvrit, G. J. Chelune, S. Hermandez, T. Dingus, L. Hewer, Ch. Koch, M. N. Metz-Lutz, G. Parlato, M. Sinaki, Charles Pierrot-Deseilligny, H. C. Diener, J. Broeckx, J. Weill-Fulazza, M. L. Villar, M. Rizzo, O. Ganslandt, C. Duran, N. A. Fletcher, G. Di Giovacchino, Susan T. Iannaccone, C. Kolig, N. Fabre, H. A. Crockard, Rita Bella, M. Tazir, E. Papagiannuli, K. Overgaard, Emma Ciafaloni, I. Lorenzetti, F. Viader, P. A. H. Millac, I. Montiel, L. H. Visser, M. Palomar, P. L. Murgia, H. Pedersen, Rafael Blesa, S. Seddigh, W. O. Renier, I. Lemahieu, H. M. L. Jansen, L. Rosin, J. Galofre, K. Mattos, M. Pondal, G. M. Hadjigeorgiou, D. Francis, L. Cantin, D. Stegeman, M. Rango, A. B. M. F. Karim, S. Schraff, B. Castellotti, I. Iriarte, E. Laborde, T. J. Tjan, R. Mutani, D. Toni, B. Bergaasco, J. G. Young, C. Klotzsch, A. Zincone, X. Ducrocq, M. Uchuya, O. J. Kolar, A. Quattrone, T. Bauermann, Nereo Bresolin, J. Vallée, B. C. Jacobs, A. Campos, Werner Poewe, J. A. Villanueva, A. W. Kornhuber, A. Malafosse, E. Diez-Tejedor, G. Jungreia, M. J. A. Puchner, A. Komiyama, O. Saribas, V. Volpini, L. Geremia, S. Bressi, A. Nibbio, Timothy E. Bates, T. z. Tzonev, E. Ideman, G. A. Damlacik, G. Martino, G. Crepaldi, T. Martino, Kjell Någren, E. Idiman, D. Samuel, J. M. Perez Trullen, Y. van der Graaf, J. O. Thorell, M. J. M. Dupuis, E. Sieber, R. D'Alessandro, C. Cazzaniga, J. Faiss, A. Tanguy, A. Schick, I. Hoksergen, A. Cardozo, R. Shakarishvili, G. K. Wennlng, J. L. Marti-Vilalta, J. Weissenbach, I. L. Simone, Amalia C. Bruni, Darius J. Adams, C. Weiller, A. Pietrangeli, F. Croria, C. Vigo-Pelfrey, Patricia Limousin, A. Ducros, G. Conti, O. Lindvall, E. Richter, M. Zuffi, A. Nappo, T. Riise, J. Wijdenes, M. J. Fernandez, J. Rosell, P. Vermersh, S. Servidei, M. S. C. Verdugo, F. Gouttiere, W. Solbach, M. Malbezin, I. S. Watanabe, A. Tumac, W. I. McDonald, D. A. Butterfield, P. P. Costa, F. deRino, F. Bamonti, J. M. Cesar, C. H. Lahoz, I. Mosely, M. Starck, M. H. Lemaitre, K. M. Stephan, S. Tex, R. Bokonjic, I. Mollee, L. Pastena, M. Gutierrez, F. Boiler, M. C. Martinez-Para, M. Velicogna, O. Obuz, A. Grinspan, M. Guarino, L. M. Cartier, E. Ruiz, D. Gambi, S. Messina, M. Villa, Michael G. Hanna, J. Valk, Leone Pascual, M. Clanet, Z. Argov, B. Ryniewicz, E. Magni, B. Berlanga, K. S. Wong, C. Gellera, C. Prevost, F. Gonzalez-Huix, R. Petraroli, J. E. G. Benedikz, I. Kojder, C. Bommelaer, L. Perusse, M. R. Bangioanni, Guy M. McKhann, A. Molina, C. Fresquet, E. Sindern, Florence Pasquier, M. J. Rosas, M. Altieri, O. Simoncini, M. Koutroumanidis, C. A. F. Tulleken, M. Dary-Auriol, S. Oueslati, H. Kruyer, I. Nishisho, C. R. Horning, A. Vital, G. V. Czettritz, J. Ph. Neau, B. Mihout, A. Ameri, M. Francis, S. Quasthoff, D. Taussig, S. Blunt, P. Valentin, C. Y. Gao, O. Heinzlef, H. d'Allens, C. Coudero, M. Erfas, G. Borghero, P. J. Modrego Pardo, M. C. Patrosso, N. L. Gershfeld, P. A. J. M. Boon, O. Sabouraud, M. Lara, J. Svennevig, G. L. Lenzi, A. Barrio, H. Villaroya, JosÇ M. Manubens, O. Boespflug-Tanguy, M. Carreras, D. A. Costiga, J. P. Breux, S. Lynn, C. Oliveras Ley, A. G. Herbaut, J. Nos, C. Tornali, Y. A. Hekster, J. L. Chopard, J. M. Manubens, P. Chemouilli, A. Jovicic, F. Dworzak, S. Smirne, S. E. Soudain, B. Gallano, D. Lubach, G. Masullo, G. Izquierdo, A. Pascual Leone Pascual, A. Sessa, V. Freitas, O. Crambes, L. Ouss, G. W. Van Dijk, P. Marchettini, P. Confalonieri, M. Donaghy, A. Munnich, M. Corbo, and M. E. L. van der Burg

Subjects
Neurology, business.industry, Media studies, Library science, Medicine, Neurology (clinical), business
Published
1994
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39. Muscle fatigue monitoring using a multifrequency bioimpedance technique

Author

J. Rosell, G. Vescio, G. Giovinazzo, L. Nescolarde, Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica, and Universitat Politècnica de Catalunya. IEB - Instrumentació Electrònica i Biomèdica

Subjects
musculoskeletal diseases, medicine.medical_specialty, Muscle fatigue, business.industry, Ciències de la salut::Medicina [Àrees temàtiques de la UPC], Impedance spectroscopy, Espectroscòpia d'impedància, Multifrequency bioimpedance, Instrumentació -- Mesurament, Muscular fatigue, Impedance, Bioelectric, Physical therapy, medicine, sense organs, Medical diagnosis, business, Biomedical engineering
Abstract

The objective of this work is to measure the changes of electrical bioimpedance module and phase related to muscular fatigue. The results could also be interesting for medical diagnosis of leg oedema, related to heart diseases, or muscular lesions. With this purpose in mind we have done multifrequency bioimpedance measurements on volunteers to evaluate the change of the impedance due to some physical exercises with the leg and with the arm. In the case of the measures performed on the arm we have obtained an initial increase of the impedance module after the first three exercises. The change of the impedance module taken after the 5th exercise respect to the first measurement was significantly lower (p

Published
2011

40. Study of an occupied low energy house 3—Moisture studies

Author

R. Morgan, J. Rosell, and H. W. Porter

Subjects
Moisture, Renewable Energy, Sustainability and the Environment, Condensation, Environmental science, Geotechnical engineering, Building and Construction, Roof, Low-energy house
Abstract

SYNOPSIS Measurements have been made of temperatures and humidities within the structures of the walls and roof of a low-energy house. The moisture control strategies in the original design appear to be ineffective, but there is no evidence of any problems arising from moisture or condensation.

Published
1993
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41. The c.859G>C variant in the SMN2 gene is associated with both type II and III SMA and originates from a common ancestor

Author

M J Barceló, Eva Also-Rallo, J Rosell, Laura Alias, Concepción Hernández-Chico, Pablo Fuentes-Prior, Josep Gamez, E Guillén-Navarro, José M. Millán, Salud Borrego, Eduardo F. Tizzano, I Hernando, F J Rodríguez-Alvarez, Serafín Bernal, Montserrat Baiget, R. Martínez-Hernández, Hospital de la Santa Creu i Sant Pau, Vall d'Hebron University Hospital [Barcelona], Hospital Virgen de la Arrixaca, Murcia, Hospital Son Dureta, Palma de Mallorca, Hospital Universitario de Asturias, Oviedo, Hospital Universitario Ramón y Cajal [Madrid], Universidad de Alcalá - University of Alcalá (UAH), Hospital Universitario Virgen del Rocío [Sevilla], Hospital La Fe, and CIBERER, Valencia, CIBER de Enfermedades Raras (CIBERER), Research Institute, Hospital de la Santa Creu i Sant Pau , Barcelona, and Hospital Vall d´Hebron, Barcelona

Subjects
Male, medicine.medical_specialty, Adolescent, SMN1, Biology, Muscular Atrophy, Spinal, 03 medical and health sciences, 0302 clinical medicine, Molecular genetics, Motor neurone disease, Genetics, medicine, Humans, Clinical genetics, Allele, Child, Gene, Phylogeny, Genetics (clinical), 030304 developmental biology, 0303 health sciences, Homozygote, Haplotype, Spinal muscular atrophy, Neuromuscular disease, SMA, medicine.disease, Phenotype, nervous system diseases, Survival of Motor Neuron 2 Protein, Neurology, Spain, Child, Preschool, Mutation, Female, 030217 neurology & neurosurgery
Abstract

International audience; Homozygous mutations of the telomeric SMN1 gene lead to degeneration of motor neurons causing spinal muscular atrophy (SMA).1 A highly similar centromeric gene (SMN2) can only partially compensate for SMN1 deficiency. The c.859G>C variant in SMN2, has been recently reported as a positive disease modifier.2,3 We identified the variant in 10 unrelated chronic SMA patients with a wide spectrum of phenotypes ranging from type II patients who can only sit to adult walkers. Haplotye analysis strongly suggests that the variant originated from a common ancestor. Our results confirm that the c.859G>C variant is a milder SMN2 allele and predict a direct correlation between SMN activity and phenotypic severity.

Published
2010
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42. Study of an occupied low energy house: 2—Ventilation studies

Author

J. Rosell, R. Morgan, and H. W. Porter

Subjects
Mechanical ventilation, Waste management, Renewable Energy, Sustainability and the Environment, medicine.medical_treatment, Energy recovery ventilation, Financial savings, Building and Construction, Low-energy house, law.invention, law, Heat recovery ventilation, Ventilation (architecture), medicine, Environmental science, health care economics and organizations, Simulation
Abstract

SYNOPSIS The ventilation requirements of a low energy house are assessed, and measurements are presented of the performance of the mechanical ventilation and heat recovery system which was installed. The results are discussed in terms of energy and financial savings. The ventilation system is necessary for healthy habitation, and energy is saved by reducing uncontrolled ventilation, but the savings due to heat recovery are not justified economically.

Published
1992
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43. Study of an occupied low energy house 1—Structure and experimental details

Author

J. Rosell Ba. MSc. DPhil., H. W. Porter BSc. DPhil., and R. Morgan Ma. PhD. FInst. P, Mim, Mcibse

Subjects
Engineering, Moisture, Renewable Energy, Sustainability and the Environment, business.industry, Energy balance, Building and Construction, Energy budget, Civil engineering, Expanded polystyrene, Low-energy house, Energy conservation, Thermal insulation, Instrumentation (computer programming), business
Abstract

SYNOPSIS An experimental low-energy house, with a novel structure incorporating an unusually large amount of expanded polystyrene insulation, was subjected to extensive monitoring of its insulation and moisture performance while occupied by a family. This paper discusses the structure and instrumentation, and reports a summary of results in which the overall energy budget is deduced.

Published
1992
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45. Total Body Water Changes Using Segmental Bioimpedance in Healthy Population with Similar Anthropometry

Author

L. Nescolarde, J. Elvira, J. Rosell-Ferrer, Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica, and Universitat Politècnica de Catalunya. IEB - Instrumentació Electrònica i Biomèdica

Subjects
business.industry, Healthy population, Body water, Bioengineering, Anatomy, Anthropometry, Enginyeria química::Biotecnologia [Àrees temàtiques de la UPC], Standard error, Water load, Bioenginyeria, Nuclear medicine, business, Whole body, Mathematics
Abstract

Electrical bioimpedance was measured in 7 body segments, and also with the standard right-side method, using 11 electrodes at 6 different frequencies in 8 healthy male subjects with similar anthropometry. Our objective was to determine the capability of segmental bioimpedance measurements to estimate small changes of water on each segment (TWsegi)and total body water (TBW) in comparison with the standard right-side method. Water was also estimated with 40K and DXA. Volunteers were measured before and after a 3.5% water load of their individual TBW. The expected TBW mean increment after water load was 1.45 l. The estimator with lower Standard Error SE was the weight of the subject (0.15 l). For impedance methods, the SE of the segmental method was 0.94 l vs. 1.41 l for right-side. Segmental volume changes obtained by DXA and Impedance compared with expected values showed maximum differences of almost 2 l for DXA and 0.5 l for Z in the abdomen. In conclusion, in a healthy sample with similar anthropometry, such as astronauts and athletes, the use of a segmental impedance method improves the accuracy of the right-side method to estimate TBW. Changes in water segments estimated by impedance where more close to expected values than using DXA.

Published
2009
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46. Transoesophageal Electronic Bioimpedance device for the study of post-transplant heart rejection

Author

G. Giovinazzo, J. Rosell, and Juan L. Ramos

Subjects
Catheter, medicine.medical_specialty, business.industry, Medicine, Radiology, business, Post transplant
Abstract

Heart transplant is today the resolving therapy for a series of heart diseases that cannot be solved using pharmacologic therapies. However, this medical approach may have significant complications, like acute rejection of the donated heart, and that is why it is important to execute some periodically invasive controls (biopsies). Previous studies have proved that heart rejection produces an electrical impedance change that could be measured with a minimally invasive technique using an intracavitary catheter introduced percutaneously. We have now designed a system to evaluate the feasibility of obtaining the same diagnosis using a transoesophageal probe.

Published
2009
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47. La relación entre la calidad del producto y los costes de transacción asociados a la coordinación vertical en la industria del vino de DOC [Denominación de Origen Calificada] Rioja

Author

Manuel Espitia-Escuer, J. Rosell Martínez, and Marta Fernández-Olmos

Subjects
WINE INDUSTRY, media_common.quotation_subject, MODELOS ECONOMETRICOS, CALIDAD, Vertical integration, Asset specificity, INTEGRACION, ESPANA, QUALITY, COST ANALYSIS, Quality (business), WINES, media_common, ECONOMIC COMPETITION, Transaction cost, ANALISIS DE COSTOS, Welfare economics, SPAIN, MERCADEO, Winery, Product (business), ECONOMETRIC MODELS, Business, VINOS, Agronomy and Crop Science, INTEGRATION, MARKETING, INDUSTRIA DEL VINO, COMPETENCIA ECONOMICA
Abstract

This paper analyzes the relationship between product quality and governance mode choice (market mode, hybrid mode or vertical integration) using the results of a survey of 187 qualified appellation of origin (DOC ) Rioja wineries. By esti mating a generalized ordered logit, it is concluded that wineries that produce high-quality wines are more likely to verti cally integrate than are wineries that produce low-quality wines. Consistent with transaction cost economics, evidence is found that asset specificity and uncertainty are important determinants of vertical integration. Finally, the size of the winery is also an important factor that affects governance mode choice in viticulture. Additional key words: quality, transaction cost , vertical relationship. Resumen Larelacionentrelacalidaddelproductoyloscostesdetransaccionasociadosalacoordinacionverticalenlaindus tria del vino de DOC Rioja Este trabajo analiza la relacion entre la calidad del producto y la eleccion del mecanismo de gobierno (mercado, modo hibrido o integracion vertical) utilizando los resultados de una encuesta realizada a 187 bodegas adscritas a la denomina ciondeorigencalificadaRioja(DOCRioja). Estimandounmodelologitordenadogeneralizado,seconcluyequelasbode gasqueproducenvinosdealtacalidadsonmasprobablesdeintegrarseverticalmentequeaquellasqueproducenvinosde bajacalidad.Consistenteconlaeconomiadecostesdetransaccion,seencuentraevidenciadequelaespecificidaddeacti vosylaincertidumbresonimportantesdeterminantesdelaintegracionvertical.Finalmente,eltamanodelabodegaestam bien un importante factor que determina la eleccion del modo de gobierno en viticultura. Palabras clave adicionales : calidad, coste de transaccion , relacion vertical.

Published
2009

48. Experimental method of mis measurement of an electrolytic cell with a passive wireless sensor

Author

J. Rodarte, R. Bragos, and J. Rosell

Subjects
Engineering, business.industry, Acoustics, Electrical engineering, Capacitance, Printed circuit board, Planar, Electromagnetic coil, Electrode, Antenna (radio), business, Electrical impedance, Computer Science::Information Theory, Voltage
Abstract

This paper presents a three coil system, with a passive wireless sensor, as an interface for a commercial network. The objective of this experiment is to achieve the system measurement of the impedances of electrolytic solutions using the magnetic impedance spectroscopy method. The interface is based on planar coils over a laminated printed circuit board; one of the planar coil acts as transmission antenna, another one is inside the electrolytic cell and the last acts as a receiver antenna. The receiver is positioned and oriented of such form that its plane is perpendicular to the plane of the transmitting antenna in order to minimize the induced voltage due to the transmission antenna. The inductive-capacitive passive remote sensor circuit consists of a square planar coil in parallel with an inter-digital electrode with a capacitance of 18 pF. It is oriented with an angle of 45deg respect to the plane of the transmitting coil. The performance measurements show a good correlation between the measured and calculated induced voltages on the receiver. We measured three different electrolytic solutions inside the cell with different ion concentrations.

Published
2008
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49. Intraoperative autotransfusion bei massivblutungen nach Thorax-Bauch-Traumen

Author

J A Guerrero, J L Tovar, O. I. Morales, J Rosell, Ruiz-Morales M, and Vara-Thorbeck R

Subjects
medicine.medical_specialty, Blood transfusion, business.industry, Mortality rate, medicine.medical_treatment, medicine.disease, Fibrinogen, Surgery, Abdominal trauma, medicine, Platelet, Fresh frozen plasma, business, Blood coagulation test, medicine.drug, Autotransfusion
Abstract

In the University Hospital of Granada (Spain), 359 surgical trauma patients underwent intraoperative autotransfusion. The patients were divided into 2 groups, according to their blood loss: group I (blood loss less than or equal to 2000 ml) and group II (blood loss greater than 2000 ml). Patients from group I did not require homologous blood transfusion. So the high risk involved in this type of transfusion was avoided. Macroscopic haemoglobinuria was only found in those patients where the Solcotrans, Viavae type of autotransfusion system was used; with the Bentley ATS system, no macroscopic haemoglobinuria was registered. With patients from group II, however, that is, those with a blood loss of more than 2000 ml, we had to fall back on homologous transfusion in addition to retransfusing autologous blood. When the transfusion exceeds 4000 ml there is increasing bleeding, which requires treatment with fresh frozen plasma, platelets and/or fibrinogen. The mortality rate of patients in group II was very high but the patients died from the severity of their injuries or from postoperative complications which were not due to autotransfusion in itself with the exception of 3 patients who underwent massive autotransfusion (12,000 to 25,000 ml) and died from acute renal failure. The main indication for intraoperative autotransfusion is without doubt abdominal and thoracic trauma which lead to high blood loss.

Published
1990
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50. [Frequency and characteristics of letters to the editor published in Farmacia Hospitalaria (1995-2006)]

Author

J, Rosell Pradas and M, Lacasaña Navarro

Subjects
Bibliometrics, Spain, Pharmacy, Periodicals as Topic, Correspondence as Topic, Authorship, Retrospective Studies
Abstract

To describe the frequency and bibliographical characteristics of letters to the editor published in the Farmacia Hospitalaria journal (hospital pharmacy) between 1995 and 2006.Descriptive and comprehensive study on documents classified as letters to the editor, which were published between 1995 and 2006. Using journal issues as a source, the following variables were identified: number of letters/year, main content, text length (words), language, use of graphs, number of authors and their professional experience, number of participating institutions, origin in terms of autonomous community, number of bibliographical references and their origin. Descriptive statistics were used.A total of 82 letters were identified, with a mean of 7 per year and 1.1 per journal. They were more frequent during the last two years, 43 (52%) of the total, following their practical non-existence between 1998 and 2003. The majority of the letters, 52 (63%), were regarding clinical cases while 23 (28%) were related to publications or were replies to the letters themselves. All letters met the requirements regarding text length, language and use of graphs. The mean number of authors was 3, and in 12 letters (14%) the limit on the number of authors was exceeded. In 56 cases (64%), the letters were written by hospital pharmacists only, however 26 (32%) were written in conjunction with hospital doctors. In 16 of the letters (20%), the authors belonged to one or more institutions. The letters mainly came from Valencia, Catalonia, Madrid and Andalusia. A total of 411 supporting references were gathered. The mean was 5 citations per letter to the editor, between 0 and 15 references, and in 17 cases (21%), the number of references was higher than the accepted limit. Of the total citations, 255 (60%) were from foreign publications.Letters to the editor in Farmacia Hospitalaria significantly increased during the last two years of the period studied and were practically non-existent before this. It is worth noting that many of the letters were written in collaboration with other health professionals and with the support of a number of institutions. It is compulsory that the letters meet publishing requirements, with the exception of a number of authors and references which were published without being thoroughly checked beforehand.

Published
2007

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