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1. Erratum to: The LUX-ZEPLIN (LZ) radioactivity and cleanliness control programs

Author

D. S. Akerib, C. W. Akerlof, D. Yu. Akimov, A. Alquahtani, S. K. Alsum, T. J. Anderson, N. Angelides, H. M. Araújo, A. Arbuckle, J. E. Armstrong, M. Arthurs, H. Auyeung, S. Aviles, X. Bai, A. J. Bailey, J. Balajthy, S. Balashov, J. Bang, M. J. Barry, D. Bauer, P. Bauer, A. Baxter, J. Belle, P. Beltrame, J. Bensinger, T. Benson, E. P. Bernard, A. Bernstein, A. Bhatti, A. Biekert, T. P. Biesiadzinski, H. J. Birch, B. Birrittella, K. E. Boast, A. I. Bolozdynya, E. M. Boulton, B. Boxer, R. Bramante, S. Branson, P. Brás, M. Breidenbach, C. A. J. Brew, J. H. Buckley, V. V. Bugaev, R. Bunker, S. Burdin, J. K. Busenitz, R. Cabrita, J. S. Campbell, C. Carels, D. L. Carlsmith, B. Carlson, M. C. Carmona-Benitez, M. Cascella, C. Chan, J. J. Cherwinka, A. A. Chiller, C. Chiller, N. I. Chott, A. Cole, J. Coleman, D. Colling, R. A. Conley, A. Cottle, R. Coughlen, G. Cox, W. W. Craddock, D. Curran, A. Currie, J. E. Cutter, J. P. da Cunha, C. E. Dahl, S. Dardin, S. Dasu, J. Davis, T. J. R. Davison, L. de Viveiros, N. Decheine, A. Dobi, J. E. Y. Dobson, E. Druszkiewicz, A. Dushkin, T. K. Edberg, W. R. Edwards, B. N. Edwards, J. Edwards, M. M. Elnimr, W. T. Emmet, S. R. Eriksen, C. H. Faham, A. Fan, S. Fayer, S. Fiorucci, H. Flaecher, I. M. Fogarty Florang, P. Ford, V. B. Francis, E. D. Fraser, F. Froborg, T. Fruth, R. J. Gaitskell, N. J. Gantos, D. Garcia, V. M. Gehman, R. Gelfand, J. Genovesi, R. M. Gerhard, C. Ghag, E. Gibson, M. G. D. Gilchriese, S. Gokhale, B. Gomber, T. G. Gonda, A. Greenall, S. Greenwood, G. Gregerson, M. G. D. van der Grinten, C. B. Gwilliam, C. R. Hall, D. Hamilton, S. Hans, K. Hanzel, T. Harrington, A. Harrison, J. Harrison, C. Hasselkus, S. J. Haselschwardt, D. Hemer, S. A. Hertel, J. Heise, S. Hillbrand, O. Hitchcock, C. Hjemfelt, M. D. Hoff, B. Holbrook, E. Holtom, J. Y-K. Hor, M. Horn, D. Q. Huang, T. W. Hurteau, C. M. Ignarra, M. N. Irving, R. G. Jacobsen, O. Jahangir, S. N. Jeffery, W. Ji, M. Johnson, J. Johnson, P. Johnson, W. G. Jones, A. C. Kaboth, A. Kamaha, K. Kamdin, V. Kasey, K. Kazkaz, J. Keefner, D. Khaitan, M. Khaleeq, A. Khazov, A. V. Khromov, I. Khurana, Y. D. Kim, W. T. Kim, C. D. Kocher, D. Kodroff, A. M. Konovalov, L. Korley, E. V. Korolkova, M. Koyuncu, J. Kras, H. Kraus, S. W. Kravitz, H. J. Krebs, L. Kreczko, B. Krikler, V. A. Kudryavtsev, A. V. Kumpan, S. Kyre, A. R. Lambert, B. Landerud, N. A. Larsen, A. Laundrie, E. A. Leason, H. S. Lee, J. Lee, C. Lee, B. G. Lenardo, D. S. Leonard, R. Leonard, K. T. Lesko, C. Levy, J. Li, Y. Liu, J. Liao, F.-T. Liao, J. Lin, A. Lindote, R. Linehan, W. H. Lippincott, R. Liu, X. Liu, C. Loniewski, M. I. Lopes, E. Lopez-Asamar, B. López Paredes, W. Lorenzon, D. Lucero, S. Luitz, J. M. Lyle, C. Lynch, P. A. Majewski, J. Makkinje, D. C. Malling, A. Manalaysay, L. Manenti, R. L. Mannino, N. Marangou, D. J. Markley, P. MarrLaundrie, T. J. Martin, M. F. Marzioni, C. Maupin, C. T. McConnell, D. N. McKinsey, J. McLaughlin, D.-M. Mei, Y. Meng, E. H. Miller, Z. J. Minaker, E. Mizrachi, J. Mock, D. Molash, A. Monte, M. E. Monzani, J. A. Morad, E. Morrison, B. J. Mount, A. St. J. Murphy, D. Naim, A. Naylor, C. Nedlik, C. Nehrkorn, H. N. Nelson, J. Nesbit, F. Neves, J. A. Nikkel, J. A. Nikoleyczik, A. Nilima, J. O’Dell, H. Oh, F. G. O’Neill, K. O’Sullivan, I. Olcina, M. A. Olevitch, K. C. Oliver-Mallory, L. Oxborough, A. Pagac, D. Pagenkopf, S. Pal, K. J. Palladino, V. M. Palmaccio, J. Palmer, M. Pangilinan, N. Parveen, S. J. Patton, E. K. Pease, B. P. Penning, G. Pereira, C. Pereira, I. B. Peterson, A. Piepke, S. Pierson, S. Powell, R. M. Preece, K. Pushkin, Y. Qie, M. Racine, B. N. Ratcliff, J. Reichenbacher, L. Reichhart, C. A. Rhyne, A. Richards, Q. Riffard, G. R. C. Rischbieter, J. P. Rodrigues, H. J. Rose, R. Rosero, P. Rossiter, R. Rucinski, G. Rutherford, J. S. Saba, L. Sabarots, D. Santone, M. Sarychev, A. B. M. R. Sazzad, R. W. Schnee, M. Schubnell, P. R. Scovell, M. Severson, D. Seymour, S. Shaw, G. W. Shutt, T. A. Shutt, J. J. Silk, C. Silva, K. Skarpaas, W. Skulski, A. R. Smith, R. J. Smith, R. E. Smith, J. So, M. Solmaz, V. N. Solovov, P. Sorensen, V. V. Sosnovtsev, I. Stancu, M. R. Stark, S. Stephenson, N. Stern, A. Stevens, T. M. Stiegler, K. Stifter, R. Studley, T. J. Sumner, K. Sundarnath, P. Sutcliffe, N. Swanson, M. Szydagis, M. Tan, W. C. Taylor, R. Taylor, D. J. Taylor, D. Temples, B. P. Tennyson, P. A. Terman, K. J. Thomas, J. A. Thomson, D. R. Tiedt, M. Timalsina, W. H. To, A. Tomás, T. E. Tope, M. Tripathi, D. R. Tronstad, C. E. Tull, W. Turner, L. Tvrznikova, M. Utes, U. Utku, S. Uvarov, J. Va’vra, A. Vacheret, A. Vaitkus, J. R. Verbus, T. Vietanen, E. Voirin, C. O. Vuosalo, S. Walcott, W. L. Waldron, K. Walker, J. J. Wang, R. Wang, L. Wang, W. Wang, Y. Wang, J. R. Watson, J. Migneault, S. Weatherly, R. C. Webb, W.-Z. Wei, M. While, R. G. White, J. T. White, D. T. White, T. J. Whitis, W. J. Wisniewski, K. Wilson, M. S. Witherell, F. L. H. Wolfs, J. D. Wolfs, D. Woodward, S. D. Worm, X. Xiang, Q. Xiao, J. Xu, M. Yeh, J. Yin, I. Young, C. Zhang, and P. Zarzhitsky

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published
2022
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2. The LUX-ZEPLIN (LZ) radioactivity and cleanliness control programs

Author

D. S. Akerib, C. W. Akerlof, D. Yu. Akimov, A. Alquahtani, S. K. Alsum, T. J. Anderson, N. Angelides, H. M. Araújo, A. Arbuckle, J. E. Armstrong, M. Arthurs, H. Auyeung, S. Aviles, X. Bai, A. J. Bailey, J. Balajthy, S. Balashov, J. Bang, M. J. Barry, D. Bauer, P. Bauer, A. Baxter, J. Belle, P. Beltrame, J. Bensinger, T. Benson, E. P. Bernard, A. Bernstein, A. Bhatti, A. Biekert, T. P. Biesiadzinski, H. J. Birch, B. Birrittella, K. E. Boast, A. I. Bolozdynya, E. M. Boulton, B. Boxer, R. Bramante, S. Branson, P. Brás, M. Breidenbach, C. A. J. Brew, J. H. Buckley, V. V. Bugaev, R. Bunker, S. Burdin, J. K. Busenitz, R. Cabrita, J. S. Campbell, C. Carels, D. L. Carlsmith, B. Carlson, M. C. Carmona-Benitez, M. Cascella, C. Chan, J. J. Cherwinka, A. A. Chiller, C. Chiller, N. I. Chott, A. Cole, J. Coleman, D. Colling, R. A. Conley, A. Cottle, R. Coughlen, G. Cox, W. W. Craddock, D. Curran, A. Currie, J. E. Cutter, J. P. da Cunha, C. E. Dahl, S. Dardin, S. Dasu, J. Davis, T. J. R. Davison, L. de Viveiros, N. Decheine, A. Dobi, J. E. Y. Dobson, E. Druszkiewicz, A. Dushkin, T. K. Edberg, W. R. Edwards, B. N. Edwards, J. Edwards, M. M. Elnimr, W. T. Emmet, S. R. Eriksen, C. H. Faham, A. Fan, S. Fayer, S. Fiorucci, H. Flaecher, I. M. Fogarty Florang, P. Ford, V. B. Francis, E. D. Fraser, F. Froborg, T. Fruth, R. J. Gaitskell, N. J. Gantos, D. Garcia, V. M. Gehman, R. Gelfand, J. Genovesi, R. M. Gerhard, C. Ghag, E. Gibson, M. G. D. Gilchriese, S. Gokhale, B. Gomber, T. G. Gonda, A. Greenall, S. Greenwood, G. Gregerson, M. G. D. van der Grinten, C. B. Gwilliam, C. R. Hall, D. Hamilton, S. Hans, K. Hanzel, T. Harrington, A. Harrison, J. Harrison, C. Hasselkus, S. J. Haselschwardt, D. Hemer, S. A. Hertel, J. Heise, S. Hillbrand, O. Hitchcock, C. Hjemfelt, M. D. Hoff, B. Holbrook, E. Holtom, J. Y-K. Hor, M. Horn, D. Q. Huang, T. W. Hurteau, C. M. Ignarra, M. N. Irving, R. G. Jacobsen, O. Jahangir, S. N. Jeffery, W. Ji, M. Johnson, J. Johnson, P. Johnson, W. G. Jones, A. C. Kaboth, A. Kamaha, K. Kamdin, V. Kasey, K. Kazkaz, J. Keefner, D. Khaitan, M. Khaleeq, A. Khazov, A. V. Khromov, I. Khurana, Y. D. Kim, W. T. Kim, C. D. Kocher, D. Kodroff, A. M. Konovalov, L. Korley, E. V. Korolkova, M. Koyuncu, J. Kras, H. Kraus, S. W. Kravitz, H. J. Krebs, L. Kreczko, B. Krikler, V. A. Kudryavtsev, A. V. Kumpan, S. Kyre, A. R. Lambert, B. Landerud, N. A. Larsen, A. Laundrie, E. A. Leason, H. S. Lee, J. Lee, C. Lee, B. G. Lenardo, D. S. Leonard, R. Leonard, K. T. Lesko, C. Levy, J. Li, Y. Liu, J. Liao, F.-T. Liao, J. Lin, A. Lindote, R. Linehan, W. H. Lippincott, R. Liu, X. Liu, C. Loniewski, M. I. Lopes, E. Lopez-Asamar, B. López Paredes, W. Lorenzon, D. Lucero, S. Luitz, J. M. Lyle, C. Lynch, P. A. Majewski, J. Makkinje, D. C. Malling, A. Manalaysay, L. Manenti, R. L. Mannino, N. Marangou, D. J. Markley, P. MarrLaundrie, T. J. Martin, M. F. Marzioni, C. Maupin, C. T. McConnell, D. N. McKinsey, J. McLaughlin, D.-M. Mei, Y. Meng, E. H. Miller, Z. J. Minaker, E. Mizrachi, J. Mock, D. Molash, A. Monte, M. E. Monzani, J. A. Morad, E. Morrison, B. J. Mount, A. St. J. Murphy, D. Naim, A. Naylor, C. Nedlik, C. Nehrkorn, H. N. Nelson, J. Nesbit, F. Neves, J. A. Nikkel, J. A. Nikoleyczik, A. Nilima, J. O’Dell, H. Oh, F. G. O’Neill, K. O’Sullivan, I. Olcina, M. A. Olevitch, K. C. Oliver-Mallory, L. Oxborough, A. Pagac, D. Pagenkopf, S. Pal, K. J. Palladino, V. M. Palmaccio, J. Palmer, M. Pangilinan, N. Parveen, S. J. Patton, E. K. Pease, B. P. Penning, G. Pereira, C. Pereira, I. B. Peterson, A. Piepke, S. Pierson, S. Powell, R. M. Preece, K. Pushkin, Y. Qie, M. Racine, B. N. Ratcliff, J. Reichenbacher, L. Reichhart, C. A. Rhyne, A. Richards, Q. Riffard, G. R. C. Rischbieter, J. P. Rodrigues, H. J. Rose, R. Rosero, P. Rossiter, R. Rucinski, G. Rutherford, J. S. Saba, L. Sabarots, D. Santone, M. Sarychev, A. B. M. R. Sazzad, R. W. Schnee, M. Schubnell, P. R. Scovell, M. Severson, D. Seymour, S. Shaw, G. W. Shutt, T. A. Shutt, J. J. Silk, C. Silva, K. Skarpaas, W. Skulski, A. R. Smith, R. J. Smith, R. E. Smith, J. So, M. Solmaz, V. N. Solovov, P. Sorensen, V. V. Sosnovtsev, I. Stancu, M. R. Stark, S. Stephenson, N. Stern, A. Stevens, T. M. Stiegler, K. Stifter, R. Studley, T. J. Sumner, K. Sundarnath, P. Sutcliffe, N. Swanson, M. Szydagis, M. Tan, W. C. Taylor, R. Taylor, D. J. Taylor, D. Temples, B. P. Tennyson, P. A. Terman, K. J. Thomas, J. A. Thomson, D. R. Tiedt, M. Timalsina, W. H. To, A. Tomás, T. E. Tope, M. Tripathi, D. R. Tronstad, C. E. Tull, W. Turner, L. Tvrznikova, M. Utes, U. Utku, S. Uvarov, J. Va’vra, A. Vacheret, A. Vaitkus, J. R. Verbus, T. Vietanen, E. Voirin, C. O. Vuosalo, S. Walcott, W. L. Waldron, K. Walker, J. J. Wang, R. Wang, L. Wang, W. Wang, Y. Wang, J. R. Watson, J. Migneault, S. Weatherly, R. C. Webb, W.-Z. Wei, M. While, R. G. White, J. T. White, D. T. White, T. J. Whitis, W. J. Wisniewski, K. Wilson, M. S. Witherell, F. L. H. Wolfs, J. D. Wolfs, D. Woodward, S. D. Worm, X. Xiang, Q. Xiao, J. Xu, M. Yeh, J. Yin, I. Young, C. Zhang, and P. Zarzhitsky

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract LUX-ZEPLIN (LZ) is a second-generation direct dark matter experiment with spin-independent WIMP-nucleon scattering sensitivity above $${1.4 \times 10^{-48}}\, {\hbox {cm}}^{2}$$ 1.4 × 10 - 48 cm 2 for a WIMP mass of $${40}\, \hbox {GeV}/{\hbox {c}}^{2}$$ 40 GeV / c 2 and a $${1000}\, \hbox {days}$$ 1000 days exposure. LZ achieves this sensitivity through a combination of a large $${5.6}\, \hbox {t}$$ 5.6 t fiducial volume, active inner and outer veto systems, and radio-pure construction using materials with inherently low radioactivity content. The LZ collaboration performed an extensive radioassay campaign over a period of six years to inform material selection for construction and provide an input to the experimental background model against which any possible signal excess may be evaluated. The campaign and its results are described in this paper. We present assays of dust and radon daughters depositing on the surface of components as well as cleanliness controls necessary to maintain background expectations through detector construction and assembly. Finally, examples from the campaign to highlight fixed contaminant radioassays for the LZ photomultiplier tubes, quality control and quality assurance procedures through fabrication, radon emanation measurements of major sub-systems, and bespoke detector systems to assay scintillator are presented.

Published
2020
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3. Grupo Técnico de Estudos do BCG em Câncer Vacina BCG (Bacillus Calmette-Guérin)

Author

Humberto Torloni, Adayr Eiras de Araújo, Hiram Silveira Lucas, Aldemar Neves Filho, Alfredo Norberto Bica, Álvaro Alberto S. Pontes, Antonio Oliveira Lima, J. Fonseca da Cunha, José Ramos Júnior, and Milton Fontes Magarão

Subjects
Vacina BCG/toxicidade, Vacina BCG/farmacologia, Neoplasias, Mycobacterium bovis, Bacillus Calmette-Guérin, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

O BCG é uma vacina preparada com germes vivos e atenuados, utilizada para a imunização contra a tuberculose. Ainda que não confira completa imunidade às pessoas vacinadas, promove aumento de resistência contra a referida doença. O Grupo Técnico de Estudos, em suas várias reuniões, tomou conhecimento de alguns resultados preliminares obtidos com o uso do BCG em Câncer no Brasil.

Published
2023

4. Recomendação Especial

Author

Humberto Torloni, Adayr Eiras de Araújo, Hiram Silveira Lucas, Aldemar Neves Filho, Alfredo Norberto Bica, Álvaro Alberto S. Pontes, Antonio Oliveira Lima, J. Fonseca da Cunha, José Ramos Júnior, and Milton Fontes Magarão

Subjects
Vacina BCG/toxicidade, Vacina BCG/farmacologia, Neoplasias, Imunoterapia, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

A imunoterapia pelo BCG ou por qualquer outro mêtodo deverá sempre ser precedida e acompanhada pela avaliação imunológica do paciente.

Published
2023

5. Normas e Recomendações para o Emprego do BCG em Câncer

Author

Humberto Torloni, Adayr Eiras de Araujo, Hiram Silveira Lucas, Aldemar Neves Filho, Alfredo Norberto Bica, Álvaro Alberto S. Pontes, Antonio Oliveira Lima, J. Fonseca da Cunha, José Ramos Júnior, and Milton Fontes Magarão

Subjects
Vacina BCG/toxicidade, Vacina BCG/farmacologia, Neoplasias, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Normas e recomendações da Divisão Nacional de Câncer – Ministério da Saúde, para o emprego do BCG em câncer.

Published
2023

7. Zika virus infections imported from Brazil to Portugal, 2015

Author

L. Zé-Zé, M.B. Prata, T. Teixeira, N. Marques, A. Mondragão, R. Fernandes, J. Saraiva da Cunha, and M.J. Alves

Subjects
Zika virus, Arbovirus, Imported cases, Infectious and parasitic diseases, RC109-216
Abstract

Zika virus is an emerging arbovirus transmitted by Aedes sp. mosquitoes like the Dengue and Chikungunya viruses. Zika virus was until recently considered a mild pathogenic mosquito-borne flavivirus with very few reported benign human infections. In 2007, an epidemic in Micronesia initiated the turnover in the epidemiological history of Zika virus and more recently, the potential association with congenital microcephaly cases in Brazil 2015, still under investigation, led the World Health Organization (WHO) to declare a Public Health Emergency of International Concern on February 1, 2016. Here, we present the clinical and laboratory aspects related to the first four imported human cases of Zika virus in Portugal from Brazil, and alert, regarding the high level of traveling between Portugal and Brazil, and the ongoing expansion of this virus in the Americas, for the threat for Zika virus introduction in Europe and the possible introduction to Madeira Island where Aedes aegypti is present.

Published
2016
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8. Miliary tuberculosis with cerebral, liver, prostate and retroesophageal involvement

Author

Raquel Goncalves, Pedro Lopes, Patrícia Mendes, João Trêpa, João Rua, Rosa Sá, Isabel Ramos, and J. Saraiva da Cunha

Subjects
Tuberculosis, milliary tuberculosis, cerebral tuberculosis, liver tuberculosis, prostate tuberculosis, retroesophageal tuberculosis, Infectious and parasitic diseases, RC109-216
Abstract

Miliary tuberculosis results from the lymphohematogenous spread of Mycobacterium tuberculosis and it is a rare form of this disease. The most affected places are the lymph nodes, pleura, and osteoarticular system, but any organ can be involved. Currently the disease is still endemic in developing countries by its close association with poor living conditions and malnutrition. Other comorbidities, particularly infection by human immunodeficiency virus (HIV), diabetes mellitus, smoking and alcoholism are of great importance in the epidemiology of this disease. The authors describe the case of an adult man from Guinea-Bissau that has been residing in Portugal for the last few months, admitted with complaints of headache. He was submitted to a computerized tomography (CT) scan of the brain which showed multiple lesions. This led to further study and the diagnosis of a disseminated tuberculosis with cerebral, liver, prostate and retroesophageal involvement. He was started on anti-tuberculosis therapy, achieving good results.

Published
2017
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9. Cytomegalic hepatitis in a patient receiving omalizumab

Author

R. Gonçalves, C. Valente, E. Ferreira, J.E. Serra, and J. Saraiva da Cunha

Subjects
Cytomegalic hepatitis, Omalizumab, Valganciclovir, Infectious and parasitic diseases, RC109-216
Abstract

Cytomegalovirus is a double stranded DNA virus that can be present in nearly all organs and body fluids. The primary infection is usually asymptomatic in the immunocompetent host and it is common among adolescents and young adults. The symptomatic form appears, in the majority of cases, as a mononucleosis syndrome with full recovery without specific treatment. We report a case of a 25 years old woman who presented with hepatitis due to CMV infection and history of omalizumab administration one month earlier. This recombinant monoclonal antibody is used to control refractory asthma and chronic spontaneous urticarial as it inhibits human IgE. Despite that, the long course of the disease lead us to initiate treatment with valganciclovir. The improvement after that was rapid and complete.

Published
2016
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10. Espondilodiscite Brucélica: Casuística dos Últimos 25 Anos

Author

Ana Lebre, Jorge Velez, Diana Seixas, Eduardo Rabadão, Joaquim Oliveira, J. Saraiva da Cunha, and A. Meliço Silvestre

Subjects
Medicine, Medicine (General), R5-920
Abstract

Introdução: A brucelose é uma zoonose endémica em Portugal, sendo a espondilodiscite brucélica uma das manifestações focais mais frequentes. Pode provocar sequelas graves, apesar da terapêutica dirigida. Material e Métodos: Estudo retrospectivo dos processos dos doentes com espondilodiscite brucélica, internados no Serviço de Doenças Infecciosas do Centro Hospitalar e Universitário de Coimbra, num período de 25 anos (1988-2012). Resultados: Foram identificados 54 doentes, 55,6% do sexo masculino, com idade média de 54,8 anos. Em 81,5% identificou-se contexto epidemiológico, maioritariamente contacto com gado ovino e caprino. A duração da sintomatologia prévia ao diagnóstico foi de 5,5 meses. Os sinais e sintomas mais frequentes foram: dor (98,1%), febre (46,3%) e défices neurológicos (25,9%). A ressonância magnética nuclear da coluna foi o exame imagiológico mais usado (77,8%) evidenciando abcessos em 29,6% dos doentes. A localização lombar predominou (77,7%). O diagnóstico etiológico foi confirmado em 47 doentes (87,0%): microbiologicamente (3 doentes), serologicamente (32 doentes) ou por ambos (12 doentes). As associações de doxiciclina com rifampicina (64,8%), ou estreptomicina (24,1%) foram as mais utilizadas, com duração média de 4,4 meses de tratamento. Um doente teve indicação cirúrgica para drenar abcesso. A evolução foi maioritariamente favorável (92,6%), sem óbitos. Discussão: A investigação de contexto epidemiológico revelou ser uma peça importante na suspeita do diagnóstico. O tratamento da brucelose osteoarticular ainda é controverso. Conclusões: A espondilodiscite brucélica deve ser considerada no diagnóstico diferencial dos doentes com lombalgia, mesmo na ausência de febre, particularmente em regiões onde a doença é endémica. O esquema antibiótico, sua duração e a necessidade de cirurgia deverão ser individualizados, com vista a um melhor prognóstico. O número de casos tem diminuído ao longo dos anos, facto relacionado com melhor controlo da endemia animal.

Published
2014
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11. Angioplastia coronária na fase aguda do enfarte do miocárdio.

Author

H M Gabriel, J Oliveira, J A da Cunha, and M C Vagueiro

Subjects
Medicine, Medicine (General), R5-920
Abstract

Primary coronary angioplasty is a reperfusion method increasingly used for the treatment of acute myocardial infarction. Several studies are reviewed, demonstrating a reduction in mortality and morbidity, namely due to recurrent ischaemia and haemorrhagic stroke, in comparison to thrombolysis. This benefit seems larger in high risk patients, such as those with cardiogenic shock, anterior wall infarction, elderly patients and those with contraindications thrombolysis or with a non diagnostic electrocardiogram.

Published
1998
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12. A adenosinadesaminase. Uma enzima pluridisciplinar.

Author

J G da Cunha

Subjects
Medicine, Medicine (General), R5-920
Abstract

Adenosine deaminase is an enzyme that actively participates in the metabolism of the adenine nucleotides. It catalyzes the irreversible hydrolytic deamination of deoxyadenosine and adenosine with the production of deoxyinosine and inosine respectively and of ammonia. This enzyme thus plays an important role in lympho-monocyte maturation and activation. The increase in its activity in different biological fluids (pleural, pericardial, peritoneal, intra-articular and cerebrospinal fluids) has been used as a rapid diagnostic test in tuberculosis infection. In human immunodeficiency virus infection, it was verified that enzymatic activity progressively increases in serum and blood cells, accompanying the natural evolution of the disease. The physiopathological mechanism has not been definitely established but the CD4+ lymphocytes and macrophages are pointed to as being accountable for the enzyme's increase in activity. For this reason, adenosine deaminase could be a marker of the cellular immune response. The study of adenosine deaminase activity in blood cells elucidated the diagnosis of severe combined immunodeficiency (due to a congenital lack of the enzyme) in 30 to 50% of the cases. One type of congenital hemolytic anemia is due to an exaggerated enzymatic activity in red blood cells.

Published
1991
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13. Angiografia de radionuclídos de equílibrio em doentes com enfarte do miocárdio prévio. Correlação com o electrocardiograma e a coronariografia.

Author

E Macieira-Coelho, M Carvalho, I Dionísio, A Prudêncio, J A da Cunha, and G Cantinho

Subjects
Medicine, Medicine (General), R5-920
Abstract

Fifty five patients with previous myocardial infarction (MI), 47 male and 8 female, mean age 55.5 +/- 8.9 years, have been studied in order to correlate the alterations found on the equilibrium (gated) radionuclide angiogram (RNA) with the location of the MI on the electrocardiogram of the obstructive lesions on coronary angiographies. Of the 55 patients studied, 22% showed no regional wall motion abnormalities (WMA). Both MI with and without Q wave may show WMA, which are significatively more frequent in patients with anterior MI on the ECG and with occlusive lesions (greater than 90%) on coronariographies. Regional localization of the WMA on the RNA does not identify the localization of the obstructive lesions. Hypokinesia was the most frequent type of WMA found both with occlusive (greater than 90%) and sub-occlusive (greater than 75%) lesions. Low values of the ejection fraction (less than 45%) were found in the presence of WMA and occlusive artery lesions.

Published
1990
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14. Thermal Diagnosis on a D.C. Motor Working with Variable Speed

Author

J. P. Da Cunha, J. D. Gabano, and G. Champenois

Subjects
Electric motor, Variable (computer science), Engineering, Model parameter, Control theory, business.industry, Thermal, Angular velocity, Thermal model, business, Nonlinear programming
Abstract

This paper deals with the thermal diagnosis on a D.C. motor working with steady or variable speed. This supervision is performed by means of parameter identification of a thermal model with parameters depending on angular speed. The model parameter is estimated by minimizing the output error by means of a Non Linear Programming according to the Marquardt algorithm. The method used allows characterizing and distinguishing several thermal behaviours.

Published
1997

15. The Alpha Magnetic Spectrometer (AMS) on the International Space Station: Part I – results from the test flight on the space shuttle

Author

P. Extermann, H. Hofer, J.P. Richeux, Jose Maria Kenny, M. Jongmanns, H. Anderhub, P. Giusti, A. Hasan, Mauro Menichelli, G. Scolieri, Y.S. Lu, I. Lopes, S. Ro, G. Schwering, Eun-Suk Seo, L. Baldini, E. Lanciotti, F. Vezzu, Maria Ionica, S.W. Ye, V. Koutsenko, Eino Valtonen, M.Y. Kim, G. Sartorelli, D. Rapin, V. Plyaskin, Werner Lustermann, Behcet Alpat, W.Q. Gu, W.Z. Zhu, C. Delgado, E. Fiandrini, Yu. Galaktionov, D.H. Kim, J. Alcaraz, S. X. Wu, W.H. Park, Felicitas Pauss, B. Verlaat, P. Berges, K. Karlamaa, S.C.C. Ting, F. Palmonari, Zhenghao Xu, Zhuoxiang Ren, F. Velcea, Tzihong Chiueh, G. Barbier, H.B. Park, R. Kossakowski, A. Klimentov, S. Urpo, Ari Mujunen, A. Lebedev, Dong-Chul Son, G. Laurenti, K. Luebelsmeyer, E. Shoumilov, W. Hungerford, H. S. Chen, N. Produit, M. Buenerd, S. Waldmeier Wicki, M. Basile, E. Riihonen, A. Mihul, Timo Laitinen, J. Yang, V. Postolache, V. Pojidaev, M. Steuer, P.C. Xia, G.S. Sun, Jian Wang, M. Ribordy, K. Hangarter, H. L. Zhuang, M. Pauluzzi, Stefan Schael, H. Suter, Guohuai Zhu, G. Boella, X.W. Tang, M. Kraber, A. Pevsner, M. A. Huang, Mao-Zhi Yang, Tao Song, J.L. Yan, N.A. Chernoplekov, J. Vandenhirtz, Z.G. Chen, C. Camps, Ciaran Williams, D. Ren, D. Luckey, I. Vetlitsky, Samuel C.C. Ting, N. Dinu, Zhidong Zhang, Anselmo Margotti, E. Cortina-Gil, M. Bourquin, A. Papi, Adrian Biland, R. Ionica, L. Djambazov, Paolo Zuccon, A. Contin, I. D'Antone, M.W. Lee, Jungwook Shin, F. Barao, G. Castellini, J. P. Da Cunha, Gui Nyun Kim, N. Fouque, P. Levtchenko, Massimo Gervasi, Kyung-Suk Cho, J. D. Burger, F. Mayet, M. Pohl, P. Yeh, G. Lu, C. Maña, C. Lechanoine-Leluc, A. Schultz von Dratzig, C. Rossin, Hengchang Liu, A. Mourao, S. Blasko, G. Laborie, C. Sbarra, Peter H. Fisher, L.G. Yan, V. Hermel, J.D. Deus, X. D. Cai, M.J. Choi, O. Grimm, J. Casaus, M. Capell, Philipp Azzarello, R. Siedling, J. Berdugo, Yun Wang, A. Arefiev, Roald Z. Sagdeev, J. Engelberg, H. von Gunten, C.L. Liu, L. Bellagamba, Changgen Yang, D. Casadei, U. Roser, R. R. McNeil, B. Meillon, Giuseppe Levi, Y.L. Chuang, K. Wiik, P. Bene, Federico Cindolo, J. J. Torsti, Antonino Zichichi, L. Brocco, J. Ritakari, Y. H. Chang, G. Kenney, P. Cannarsa, Y.Y. Choi, D. Barancourt, J. Favier, Waclaw Karpinski, E. Babucci, U. Becker, Dawei Zhao, R. Becker, Z.R. Dong, E. Perrin, K.S. Kim, Claudia Cecchi, F. J. Eppling, M. Aguilar, V. Shoutko, S. Bizzaglia, G. Esposito, M. Pimenta, G. Fluegge, D. Grandi, B. Bertucci, D. Santos, G. Ambrosi, T. S. Dai, A. Pesci, B.C. Wang, D. Vité, G. Lamanna, G. Viertel, J. P. Vialle, H.F. Chen, G.P. Barreira, W. J. Burger, Frank Raupach, Roberto Battiston, L. Ao, J. Ulbricht, Hao Zhang, S.C. Lee, J. Trümper, P. Emonet, M. J. Boschini, V. Commichau, E. P. Velikhov, B. Zimmermann, Merja Tornikoski, Markus Cristinziani, T. Eronen, P. G. Rancoita, W. Wallraff, G. Bruni, Aguilar, M, Alcaraz, J, Allaby, J, Alpat, B, Ambrosi, G, Anderhub, H, Ao, L, Arefiev, A, Azzarello, P, Babucci, E, Baldini, L, Basile, M, Berdugo, J, Berges, P, Bertucci, B, Biland, A, Bizzaglia, S, Blasko, S, Boella, G, Boschini, M, Bourquin, M, Brocco, L, Bruni, G, Buenerd, M, Burger, J, Burger, W, Cai, X, Camps, C, Cannarsa, P, Capell, M, Casadei, D, Casaus, J, Castellini, G, Cecchi, C, Chang, Y, Chen, H, Chen, Z, Chernoplekov, N, Chiueh, T, Cho, K, Choi, M, Choi, Y, Chuang, Y, Cindolo, F, Commichau, V, Contin, A, Cortina-Gil, E, Cristinziani, M, da Cunha, J, Dai, T, Delgado, C, Deus, J, Dinu, N, Djambazov, L, D'Antone, I, Dong, Z, Emonet, P, Engelberg, J, Eppling, F, Eronen, T, Esposito, G, Extermann, P, Favier, J, Fiandrini, E, Fisher, P, Fluegge, G, Fouque, N, Galaktionov, Y, Gervasi, M, Giusti, P, Grandi, D, Grimms, O, Gu, W, Hangarter, K, Hasan, A, Hermel, V, Hofer, H, Huang, M, Hungerford, W, Ionica, M, Ionica, R, Jongmanns, M, Karlamaa, K, Karpinski, W, Kenney, G, Kenny, J, Kim, D, Kim, G, Kim, K, Kim, M, Klimentov, A, Kossakowski, R, Koutsenko, V, Kraeber, M, Laborie, G, Laitinen, T, Lamanna, G, Lanciotti, E, Laurenti, G, Lebedev, A, Lechanoine-Leluc, C, Lee, M, Lee, S, Levi, G, Levtchenko, P, Liu, C, Liu, H, Lopes, I, Lu, G, Lu, Y, Lubelsmeyer, K, Luckey, D, Lustermann, W, Mana, C, Margotti, A, Mayet, F, Mcneil, R, Meillon, B, Menichelli, M, Mihul, A, Mourao, A, Mujunen, A, Palmonari, F, Papi, A, Park, H, Park, W, Pauluzzi, M, Pauss, F, Perrin, E, Pesci, A, Pevsner, A, Pimenta, M, Plyaskin, V, Pojidaev, V, Pohl, M, Postolache, V, Produit, N, Rancoita, P, Rapin, D, Raupach, F, Ren, D, Ren, Z, Ribordy, M, Richeux, J, Riihonen, E, Ritakari, J, Ro, S, Roeser, U, Rossin, C, Sagdeev, R, Santos, D, Sartorelli, G, Sbarra, C, Schael, S, von Dratzig, A, Schwering, G, Scolieri, G, Seo, E, Shin, J, Shoutko, V, Shoumilov, E, Siedling, R, Son, D, Song, T, Steuer, M, Sun, G, Suter, H, Tang, X, Ting, S, Tornikoski, M, Torsti, J, Trumper, J, Ulbricht, J, Urpo, S, Valtonen, E, Vandenhirtz, J, Velcea, F, Velikhov, E, Verlaat, B, Vetlitsky, I, Vezzu, F, V, Jp, Viertel, G, Vite, D, Von Gunten, H, Wicki, S, Wallraff, W, Wang, B, Wang, J, Wang, Y, Wiik, K, Williams, C, Wu, S, Xia, P, Yan, J, Yan, L, Yang, C, Yang, J, Yang, M, Ye, S, Yeh, P, Xu, Z, Zhang, H, Zhang, Z, Zhao, D, Zhu, G, Zhu, W, Zhuang, H, Zichichi, A, Zimmermann, B, Zuccon, P, Ambrosi, Giovanni, Azzarello, Philipp, Bene, Pierre, Bourquin, Maurice, Cortina Gil, Eduardo, Cristinziani, Markus, Emonet, Pascal Philippe, Extermann, Pierre, Leluc, Catherine, Perrin, Eric, Pohl, Martin, Produit, Nicolas, Rapin, Divic Jean, Ribordy, Mathieu, Richeux, Jean-Pierre, Vite, Davide, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), AMS, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, CIEMAT, E-28040, Madrid, Spain, and UCL - SST/IRMP - Institut de recherche en mathématique et physique

Subjects
Physics, 010308 nuclear & particles physics, FIS/06 - FISICA PER IL SISTEMA TERRA E PER IL MEZZO CIRCUMTERRESTRE, General Physics and Astronomy, chemistry.chemical_element, Electron, ddc:500.2, 01 natural sciences, Spectral line, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Nuclear physics, FIS/05 - ASTRONOMIA E ASTROFISICA, Positron, Earth's magnetic field, FIS/01 - FISICA SPERIMENTALE, chemistry, 13. Climate action, Antiproton, 0103 physical sciences, Alpha Magnetic Spectrometer, Nucleon, 010303 astronomy & astrophysics, AMS, Cosmic Rays, Antimatter, Helium, FIS/04 - FISICA NUCLEARE E SUBNUCLEARE
Abstract

The Alpha Magnetic Spectrometer (AMS) was flown on the space shuttle Discovery during flight STS-91 (June 1998) in a 51.7 deg orbit at altitudes between 320 and 390 km. A search for antihelium nuclei in the rigidity range 1–140 GV was performed. No antihelium nuclei were detected at any rigidity. An upper limit on the flux ratio of antihelium to helium of < 1.1×10^−6 was obtained. The high energy proton, electron, positron, helium, antiproton and deuterium spectra were accurately measured. For each particle and nuclei two distinct spectra were observed: a higher energy spectrum and a substantial second spectrum. Positrons in the second spectrum were found to be much more abundant than electrons. Tracing particles from the second spectra shows that most of them travel for an extended period of time in the geomagnetic field, and that the positive particles (p and e+) and negative ones (e−) originate from two complementary geographic regions. The second helium spectrum flux over the energy range 0.1–1.2 GeV/nucleon was measured to be (6.3 ± 0.9) × 10^−3(m^2 s sr)^−1. Over 90 percent of the helium flux was determined to be 3He at the 90% confidence level

Published
2002

16. Search for antihelium in cosmic rays

Author

Z.R. Dong, S. Bizzaglia, G. Ambrosi, J. Casaus, M. Pimenta, T. S. Dai, Samuel C.C. Ting, L. Djambazov, B.C. Wang, G. Molinari, A. Klimentov, B. Bertucci, S. X. Wu, R. Pilastrini, G. Lamanna, L.G. Yan, R. Siedling, J. Favier, Philipp Azzarello, J. J. Torsti, Antonino Zichichi, A. Hasan, Mauro Menichelli, L. Ao, Inkyu Park, J.P. Vialle, M. Steuer, P.C. Xia, Peter H. Fisher, Ilya Usoskin, P. G. Rancoita, Jing Wang, F. Palmonari, J. Isbert, M. Ribordy, G. Boella, H. von Gunten, P. Crespo, W. J. Burger, N. Fouque, R. Ionica, Federico Cindolo, J.P. Richeux, R. Cavalletti, D.X. Zhao, U. Roeser, N.A. Chernoplekov, C. G. Yang, Nicolas Produit, M. Buenerd, A. Cotta-Ramusino, R. Flaminio, J. P. Da Cunha, Anselmo Margotti, D. Rapin, V. Plyaskin, W. Kim, Roberto Battiston, G.Y. Zhu, W.Z. Zhu, G. Fluegge, G. Bruni, G. Viertel, P. Levtchenko, E. Fiandrini, G. Laurenti, K. Luebelsmeyer, S. Waldmeier Wicki, S.C. Lee, Yu. Galaktionov, F. Massera, D. Vité, J. Ulbricht, A. Chiarini, Hao Zhang, H. S. Chen, C. Rossin, G. Pancaldi, Felicitas Pauss, S. Recupero, Ciaran Williams, R. Kossakowski, W. Karpinski, J. Alcaraz, F. Barao, P. Yeh, E. Emonet, L.K. Ding, H.T. Liu, E. P. Velikhov, G. Torromeo, M. Basile, G.S. Sun, A. Pevsner, J.L. Yan, X. D. Cai, L. Baldini, F. Mezzanotte, C.L. Liu, L. Bellagamba, S. Blasko, K. Hangarter, J. Berdugo, Adrian Biland, G. Barbier, J. Vandenhirtz, V. Hermel, A. Arefiev, E. Prati, Jose Maria Kenny, R. R. McNeil, T.G. Guzik, B. Meillon, W.K. Gu, G. Kenney, I. D'Antone, J.P. Wefel, Markus Cristinziani, T. Eronen, R. Becker, Y.L. Chuang, P. Bene, B. Alpat, D. Luckey, E. Riihonen, A. Mihul, M. Jongmanns, C.C. Feng, D. Casadei, W. Wallraff, J. Krieger, H.L. Zhuang, G. Castellini, Massimo Gervasi, Zhuoxiang Ren, G. Schwering, W. Hungerford, A. Papi, Timo Laitinen, D. Santos, F. Tenbusch, B. Verlaat, P. Berges, Raffaele Mezzenga, S. Urpo, Ari Mujunen, G. Laborie, V. Shoutko, M. Pauluzzi, Y. S. Lu, G.P. Barreira, Yun Wang, V. Commichau, J. Truemper, A. Pesci, D. Ren, M. Capell, V. Koutsenko, Eino Valtonen, F. Vezzu, P. Cannarsa, C. Camps, T.P. Li, M. Ionica, H. Postema, A. Contin, M. Yang, E. Babucci, U. Becker, A. Lebedev, Dong-Chul Son, P. Giusti, I. Lopes, E. Perrin, F. J. Eppling, D. Alvisi, G. Lu, F. Raupach, C. Maña, P. Extermann, S. M. Ting, H. Hofer, G. Esposito, I. Vetlitsky, G. Sartorelli, M. Lolli, G. Maehlum, E.A. Werner, Fabio Finelli, Z.G. Chen, Werner Lustermann, Giuseppe Levi, X. W. Tang, Tao Song, M. Bourquin, V. Pojidaev, E. Shoumilov, H. Suter, J. D. Burger, Roald Z. Sagdeev, A. Mourao, J. Ritakari, Y. H. Chang, D. Barancourt, N. Dinu, H. Anderhub, Tzihong Chiueh, M. A. Huang, Jorge Dias de Deus, F. Mayet, A. Schultz von Dratzig, Alcaraz, J, Alvisi, D, Alpat, B, Ambrosi, G, Anderhub, H, Ao, L, Arefiev, A, Azzarello, P, Babucci, E, Baldini, L, Basile, M, Barancourt, D, Barao, F, Barbier, G, Barreira, G, Battiston, R, Becker, R, Becker, U, Bellagamba, L, Béné, P, Berdugo, J, Berges, P, Bertucci, B, Biland, A, Bizzaglia, S, Blasko, S, Boella, G, Bourquin, M, Bruni, G, Buenerd, M, Burger, J, Burger, W, Cai, X, Cavalletti, R, Camps, C, Cannarsa, P, Capell, M, Casadei, D, Casaus, J, Castellini, G, Chang, Y, Chen, H, Chen, Z, Chernoplekov, N, Chiarini, A, Chiueh, T, Chuang, Y, Cindolo, F, Commichau, V, Contin, A, Cotta Ramusino, A, Crespo, P, Cristinziani, M, Dacunha, J, Dai, T, Deus, J, Ding, L, Dinu, N, Djambazov, L, D'Antone, I, Dong, Z, Emonet, P, Eppling, F, Eronen, T, Esposito, G, Extermann, P, Favier, J, Feng, C, Fiandrini, E, Finelli, F, Fisher, P, Flaminio, R, Fluegge, G, Fouque, N, Galaktionov, Y, Gervasi, M, Giusti, P, Gu, W, Guzik, T, Hangarter, K, Hasan, A, Hermel, V, Hofer, H, Huang, M, Hungerford, W, Ionica, M, Ionica, R, Isbert, J, Jongmanns, M, Karpinski, W, Kenney, G, Kenny, J, Kim, W, Klimentov, A, Krieger, J, Kossakowski, R, Koutsenko, V, Laborie, G, Laitinen, T, Lamanna, G, Laurenti, G, Lebedev, A, Lee, S, Levi, G, Levtchenko, P, Li, T, Liu, C, Liu, H, Lolli, M, Lopes, I, Lu, G, Lu, Y, Lübelsmeyer, K, Luckey, D, Lustermann, W, Maehlum, G, Maña, C, Margotti, A, Massera, F, Mayet, F, Mcneil, R, Meillon, B, Menichelli, M, Mezzanotte, F, Mezzenga, R, Mihul, A, Molinari, G, Mourao, A, Mujunen, A, Palmonari, F, Pancaldi, G, Papi, A, Park, I, Pauluzzi, M, Pauss, F, Perrin, E, Pesci, A, Pevsner, A, Pilastrini, R, Pimenta, M, Plyaskin, V, Pojidaev, V, Postema, H, Prati, E, Produit, N, Rancoita, P, Rapin, D, Raupach, F, Recupero, S, Ren, D, Ren, Z, Ribordy, M, Richeux, J, Riihonen, E, Ritakari, J, Roeser, U, Roissin, C, Sagdeev, R, Santos, D, Sartorelli, G, Schultzvondratzig, A, Schwering, G, Shoutko, V, Shoumilov, E, Siedling, R, Son, D, Song, T, Steuer, M, Sun, G, Suter, H, Tang, X, Ting, S, Tenbusch, F, Torromeo, G, Torsti, J, Trümper, J, Ulbricht, J, Urpo, S, Usoskin, I, Valtonen, E, Vandenhirtz, J, Velikhov, E, Verlaat, B, Vetlitsky, I, Vezzu, F, Vialle, J, Viertel, G, Vité, D, Vongunten, H, Waldmeierwicki, S, Wallraff, W, Wang, B, Wang, J, Wang, Y, Wefel, J, Werner, E, Williams, C, Wu, S, Xia, P, Yan, J, Yan, L, Yang, C, Yang, M, Yeh, P, Zhang, H, Zhao, D, Zhu, G, Zhu, W, Zhuang, H, Zichichi, A, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), and AMS

Subjects
Astrophysics and Astronomy, Nuclear and High Energy Physics, FOS: Physical sciences, chemistry.chemical_element, Space Shuttle, Cosmic ray, Astrophysics, 7. Clean energy, 01 natural sciences, High Energy Physics - Experiment, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], High Energy Physics - Experiment (hep-ex), FIS/05 - ASTRONOMIA E ASTROFISICA, Rigidity (electromagnetism), 0103 physical sciences, Alpha Magnetic Spectrometer, 010306 general physics, Helium, Physics, 010308 nuclear & particles physics, Astrophysics (astro-ph), Astronomy, Flux ratio, FIS/01 - FISICA SPERIMENTALE, chemistry, Cosmic rays: anti-helium, FIS/04 - FISICA NUCLEARE E SUBNUCLEARE
Abstract

The Alpha Magnetic Spectrometer (AMS) was flown on the space shuttle Discovery during flight STS-91 in a 51.7 degree orbit at altitudes between 320 and 390 km. A total of 2.86 * 10^6 helium nuclei were observed in the rigidity range 1 to 140 GV. No antihelium nuclei were detected at any rigidity. An upper limit on the flux ratio of antihelium to helium of < 1.1 * 10^-6 is obtained., 18 pages, Latex, 9 .eps figures

Published
2000

17. Leptons in near earth orbit

Author

L. Djambazov, P. Giusti, G. Scolieri, I. Lopes, Dawei Zhao, P. G. Rancoita, E. Babucci, U. Becker, F. Vezzu, E. Perrin, F. J. Eppling, G. Barbier, S. M. Ting, S.C. Lee, R. Ionica, F. Palmonari, H. von Gunten, G. Esposito, Z.R. Dong, Federico Cindolo, Changgen Yang, H. T. Liu, Diego Casadei, Yu. Galaktionov, D. Vité, A. Lebedev, U. Roeser, G. Castellini, Dong-Chul Son, Z. L. Ren, J. Alcaraz, Guohuai Zhu, Yun Wang, S. Bizzaglia, A. Arefiev, P. Extermann, H. Hofer, W. Wallraff, Ilya Usoskin, Jing Wang, P. Levtchenko, P. Emonet, T. S. Dai, H. Anderhub, Waclaw Karpinski, E. Fiandrini, R. Becker, P. Cannarsa, R. R. McNeil, D. Rapin, C. Roissin, B.C. Wang, M. Pimenta, E. P. Velikhov, B. Zimmermann, V. Plyaskin, Roald Z. Sagdeev, B. Meillon, H. S. Chen, L. Baldini, J. Casaus, A. Hasan, E. Riihonen, Mauro Menichelli, K. Karlamaa, A. Mihul, Giovanna Bruni, G. Kenney, N. Produit, D. Grandi, M. Ribordy, S. Urpo, W. J. Burger, Merja Tornikoski, Markus Cristinziani, G. Schwering, A. Pesci, I. Vetlitsky, L.G. Yan, I. D'Antone, Y. H. Chang, Tengfei Song, W.Q. Gu, B. Bertucci, D. Barancourt, N. Dinu, V. Commichau, G. Laborie, P. Crespo, Mao-Zhi Yang, J. J. Torsti, M. Jongmanns, Antonino Zichichi, Adrian Biland, V. Postolache, Peter H. Fisher, T. Eronen, C. Camps, J. Berdugo, N. Fouque, J. P. Da Cunha, Massimo Gervasi, J. Vandenhirtz, H. F. Chen, F. Barao, S. Blasko, Zhenyu Zhang, H.L. Zhuang, G. Viertel, E. Shoumilov, Jose Maria Kenny, W. Hungerford, F. Velcea, Y.L. Chuang, O. Grimm, J.L. Yan, K. Wiik, P. Bene, H. Suter, J.P. Richeux, Tzihong Chiueh, V. Hermel, M. Buenerd, Timo Laitinen, M. Capell, A. Papi, Eun-Suk Seo, M. Pauluzzi, R. Siedling, G. Fluegge, W.Z. Zhu, Giovanni Ambrosi, L. Ao, M. Bourquin, D. Ren, G. Lu, C. Maña, V. Koutsenko, Eino Valtonen, Felicitas Pauss, R. Kossakowski, A. Klimentov, G.S. Sun, A. Contin, Samuel C.C. Ting, M. A. Huang, M. J. Boschini, M. Basile, K. Hangarter, Roberto Battiston, A. Pevsner, D. Luckey, F. Mayet, Ciaran Williams, J. Ulbricht, A. Schultz von Dratzig, P. Yeh, G. Laurenti, Claudia Cecchi, S. Waldmeier Wicki, Hao Zhang, Z.G. Chen, S. X. Wu, J. Ritakari, X. D. Cai, J. Trümper, V. Shoutko, Inkyu Park, M. Steuer, P.C. Xia, S.W. Ye, C.L. Liu, L. Bellagamba, G. Lamanna, J. Engelberg, Xiao-Dong Tang, J. P. Vialle, K. Lübelsmeyer, G.P. Barreira, M. Ionica, P. Azzarello, Z. Z. Xu, V. Pojidaev, B. Verlaat, G. Sartorelli, P. Berges, Giuseppe Levi, Lu Yuzhang, Ari Mujunen, Werner Lustermann, Behcet Alpat, J. D. Burger, Frank Raupach, A. Mourao, J.D. Deus, L. Brocco, G. Boella, N.A. Chernoplekov, Anselmo Margotti, W. Kim, M. Kraeber, J. Favier, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), AMS, Alcaraz, J, Alpat, B, Ambrosi, G, Anderhub, H, Ao, L, Arefiev, A, Azzarello, P, Babucci, E, Baldini, L, Basile, M, Barancourt, D, Barao, F, Barbier, G, Barreira, G, Battiston, R, Becker, R, Becker, U, Bellagamba, L, Béné, P, Berdugo, J, Berges, P, Bertucci, B, Biland, A, Bizzaglia, S, Blasko, S, Boella, G, Boschini, M, Bourquin, M, Brocco, L, Bruni, G, Buenerd, M, Burger, J, Burger, W, Cai, X, Camps, C, Cannarsa, P, Capell, M, Casadei, D, Casaus, J, Castellini, G, Cecchi, C, Chang, Y, Chen, H, Chen, Z, Chernoplekov, N, Chiueh, T, Chuang, Y, Cindolo, F, Commichau, V, Contin, A, Crespo, P, Cristinziani, M, Cunha, J, Dai, T, Deus, J, Dinu, N, Djambazov, L, D'Antone, I, Dong, Z, Emonet, P, Engelberg, J, Eppling, F, Eronen, T, Esposito, G, Extermann, P, Favier, J, Fiandrini, E, Fisher, P, Fluegge, G, Fouque, N, Galaktionov, Y, Gervasi, M, Giusti, P, Grandi, D, Grimm, O, Gu, W, Hangarter, K, Hasan, A, Hermel, V, Hofer, H, Huang, M, Hungerford, W, Ionica, M, Ionica, R, Jongmanns, M, Karlamaa, K, Karpinski, W, Kenney, G, Kenny, J, Kim, W, Klimentov, A, Kossakowski, R, Koutsenko, V, Kraeber, M, Laborie, G, Laitinen, T, Lamanna, G, Laurenti, G, Lebedev, A, Lee, S, Levi, G, Levtchenko, P, Liu, C, Liu, H, Lopes, I, Lu, G, Lu, Y, Lübelsmeyer, K, Luckey, D, Lustermann, W, Maña, C, Margotti, A, Mayet, F, Mcneil, R, Meillon, B, Menichelli, M, Mihul, A, Mourao, A, Mujunen, A, Palmonari, F, Papi, A, Park, I, Pauluzzi, M, Pauss, F, Perrin, E, Pesci, A, Pevsner, A, Pimenta, M, Plyaskin, V, Pojidaev, V, Postolache, V, Produit, N, Rancoita, P, Rapin, D, Raupach, F, Ren, D, Ren, Z, Ribordy, M, Richeux, J, Riihonen, E, Ritakari, J, Roeser, U, Roissin, C, Sagdeev, R, Sartorelli, G, Dratzig, A, Schwering, G, Scolieri, G, Seo, E, Shoutko, V, Shoumilov, E, Siedling, R, Son, D, Song, T, Steuer, M, Sun, G, Suter, H, Tang, X, Ting, S, Tornikoski, M, Torsti, J, Trümper, J, Ulbricht, J, Urpo, S, Usoskin, I, Valtonen, E, Vandenhirtz, J, Velcea, F, Velikhov, E, Verlaat, B, Vetlitsky, I, Vezzu, F, Vialle, J, Viertel, G, Vité, D, Gunten, H, Wicki, S, Wallraff, W, Wang, B, Wang, J, Wang, Y, Wiik, K, Williams, C, Wu, S, Xia, P, Yan, J, Yan, L, Yang, C, Yang, M, Ye, S, Yeh, P, Xu, Z, Zhang, H, Zhang, Z, Zhao, D, Zhu, G, Zhu, W, Zhuang, H, Zichichi, A, and Zimmermann, B

Subjects
Nuclear and High Energy Physics, Cosmic Rays, AMS, Cosmic ray, Electron, Astrophysics, Kinetic energy, 01 natural sciences, Spectral line, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Nuclear physics, FIS/05 - ASTRONOMIA E ASTROFISICA, AMS-01, 0103 physical sciences, Alpha Magnetic Spectrometer, AMS, 010306 general physics, 010303 astronomy & astrophysics, Physics, Earth's orbit, Cosmic rays: leptons, Cosmic Rays, cosmic rays, AMS-01, FIS/01 - FISICA SPERIMENTALE, Earth's magnetic field, 13. Climate action, High Energy Physics::Experiment, FIS/04 - FISICA NUCLEARE E SUBNUCLEARE, Lepton
Abstract

The lepton spectra in the kinetic energy ranges 0.2 to 40 GeV for e − and 0.2 to 3 GeV for e + were measured by the Alpha Magnetic Spectrometer (AMS) during space shuttle flight STS–91 at altitudes near 380 km. From the origin of the leptons two distinct spectra were observed: a higher energy spectrum and a substantial second spectrum with positrons much more abundant than electrons. Tracing leptons from the second spectra shows that most of these leptons travel for an extended period of time in the geomagnetic field and that the e + and e − originate from two complementary geographic regions.

Published
2000

18. Helium in near earth orbit

Author

D. Vité, Peter H. Fisher, Yu. Galaktionov, J. Alcaraz, Roald Z. Sagdeev, D.X. Zhao, K. Karlamaa, A. Arefiev, S.W. Ye, E. Riihonen, W. Hungerford, M. A. Huang, R. R. McNeil, B. Meillon, V. Shoutko, G. Kenney, J. Ritakari, Y. H. Chang, J. Engelberg, C. Camps, G. Sartorelli, D. Barancourt, A. Mihul, Timo Laitinen, R. Ionica, Jorge Dias de Deus, W. Kim, H. von Gunten, P. G. Rancoita, V. Postolache, M. Pauluzzi, G. Lu, C. Maña, Werner Lustermann, Federico Cindolo, F. Mayet, G. Fluegge, Mao-Zhi Yang, D. Ren, A. Schultz von Dratzig, G. Barbier, W.Z. Zhu, W. J. Burger, A. Papi, J. Casaus, U. Roeser, M. Ribordy, G. Ambrosi, Y.L. Chuang, A. Contin, P. Levtchenko, M. Buenerd, X.W. Tang, M. Pimenta, W. Wallraff, T. S. Dai, F. Vezzu, B. Verlaat, Maria Ionica, G.S. Sun, Samuel C.C. Ting, Frank Raupach, E. Shoumilov, P. Berges, B.C. Wang, S. Urpo, Ari Mujunen, G. Bruni, H. Suter, P. Bene, Hengchang Liu, D. Rapin, C. Roissin, V. Plyaskin, G. Laurenti, S. Waldmeier Wicki, D. Grandi, A. Pevsner, Z. L. Ren, F. Velcea, Tao Song, G. Lamanna, M. J. Boschini, B. Bertucci, J. J. Torsti, Antonino Zichichi, Waclaw Karpinski, J. Berdugo, H. Anderhub, V. Commichau, R. Becker, Roberto Battiston, B. Alpat, N. Fouque, J.P. Richeux, Zhenghao Xu, M. Bourquin, A. Lebedev, Dong-Chul Son, E. Fiandrini, F. Palmonari, Yun Wang, G. Boella, P. Yeh, J.L. Yan, H.F. Chen, L. Brocco, Felicitas Pauss, L. Baldini, A. Pesci, H. S. Chen, J. Ulbricht, K. Wiik, R. Kossakowski, N.A. Chernoplekov, Nicolas Produit, K. Lübelsmeyer, S. X. Wu, M. Basile, P. Cannarsa, Hao Zhang, S. Blasko, M. Jongmanns, G. Castellini, E. P. Velikhov, B. Zimmermann, G.P. Barreira, K. Hangarter, H. L. Zhuang, Anselmo Margotti, Tzihong Chiueh, J. P. Da Cunha, Y.S. Lu, Inkyu Park, J.P. Vialle, Ciaran Williams, A. Klimentov, G. Laborie, L. Ao, M. Pohl, N. Dinu, Merja Tornikoski, Markus Cristinziani, M. Steuer, P.C. Xia, G. Viertel, D. Luckey, Jose Maria Kenny, J. Trümper, L. Djambazov, Paolo Zuccon, O. Grimm, T. Eronen, E. Babucci, U. Becker, I. Vetlitsky, S.C. Lee, Eun-Suk Seo, E. Perrin, M. Kraeber, F. J. Eppling, S. M. Ting, Changgen Yang, V. Koutsenko, Eino Valtonen, P. Giusti, Adrian Biland, G. Scolieri, G. Esposito, Z.R. Dong, Claudia Cecchi, Philipp Azzarello, I. Lopes, Massimo Gervasi, P. Emonet, S. Bizzaglia, Z.G. Chen, J. Favier, M. Capell, R. Siedling, X. D. Cai, C.L. Liu, L. Bellagamba, L.G. Yan, Ilya Usoskin, Jing Wang, J. Vandenhirtz, A. Hasan, Mauro Menichelli, G. Schwering, P. Extermann, W.Q. Gu, H. Hofer, F. Barao, V. Hermel, Zhidong Zhang, D. Casadei, I. D'Antone, Guohuai Zhu, J. D. Burger, A. Mourao, V. Pojidaev, Giuseppe Levi, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), AMS, Alcaraz, J, Alpat, B, Ambrosi, G, Anderhub, H, Ao, L, Arefiev, A, Azzarello, P, Babucci, E, Baldini, L, Basile, M, Barancourt, D, Barao, F, Barbier, G, Barreira, G, Battiston, R, Becker, R, Becker, U, Bellagamba, L, Béné, P, Berdugo, J, Berges, P, Bertucci, B, Biland, A, Bizzaglia, S, Blasko, S, Boella, G, Boschini, M, Bourquin, M, Brocco, L, Bruni, G, Buenerd, M, Burger, J, Burger, W, Cai, X, Camps, C, Cannarsa, P, Capell, M, Casadei, D, Casaus, J, Castellini, G, Cecchi, C, Chang, Y, Chen, H, Chen, Z, Chernoplekov, N, Chiueh, T, Chuang, Y, Cindolo, F, Commichau, V, Contin, A, Cristinziani, M, Cunha, J, Dai, T, Deus, J, Dinu, N, Djambazov, L, D'Antone, I, Dong, Z, Emonet, P, Engelberg, J, Eppling, F, Eronen, T, Esposito, G, Extermann, P, Favier, J, Fiandrini, E, Fisher, P, Fluegge, G, Fouque, N, Galaktionov, Y, Gervasi, M, Giusti, P, Grandi, D, Grimm, O, Gu, W, Hangarter, K, Hasan, A, Hermel, V, Hofer, H, Huang, M, Hungerford, W, Ionica, M, Ionica, R, Jongmanns, M, Karlamaa, K, Karpinski, W, Kenney, G, Kenny, J, Kim, W, Klimentov, A, Kossakowski, R, Koutsenko, V, Kraeber, M, Laborie, G, Laitinen, T, Lamanna, G, Laurenti, G, Lebedev, A, Lee, S, Levi, G, Levtchenko, P, Liu, C, Liu, H, Lopes, I, Lu, G, Lu, Y, Lübelsmeyer, K, Luckey, D, Lustermann, W, Maña, C, Margotti, A, Mayet, F, Mcneil, R, Meillon, B, Menichelli, M, Mihul, A, Mourao, A, Mujunen, A, Palmonari, F, Papi, A, Park, I, Pauluzzi, M, Pauss, F, Perrin, E, Pesci, A, Pevsner, A, Pimenta, M, Plyaskin, V, Pojidaev, V, Pohl, M, Postolache, V, Produit, N, Rancoita, P, Rapin, D, Raupach, F, Ren, D, Ren, Z, Ribordy, M, Richeux, J, Riihonen, E, Ritakari, J, Roeser, U, Roissin, C, Sagdeev, R, Sartorelli, G, Schultz&nbsp, von&nbsp, Dratzig, A, Schwering, G, Scolieri, G, Seo, E, Shoutko, V, Shoumilov, E, Siedling, R, Son, D, Song, T, Steuer, M, Sun, G, Suter, H, Tang, X, Ting, S, Tornikoski, M, Torsti, J, Trümper, J, Ulbricht, J, Urpo, S, Usoskin, I, Valtonen, E, Vandenhirtz, J, Velcea, F, Velikhov, E, Verlaat, B, Vetlitsky, I, Vezzu, F, Vialle, J, Viertel, G, Vité, D, Gunten, H, Wicki, S, Wallraff, W, Wang, B, Wang, J, Wang, Y, Wiik, K, Williams, C, Wu, S, Xia, P, Yan, J, Yan, L, Yang, C, Yang, M, Ye, S, Yeh, P, Xu, Z, Zhang, H, Zhang, Z, Zhao, D, Zhu, G, Zhu, W, Zhuang, H, Zichichi, A, Zimmermann, B, Zuccon, P, Ambrosi, Giovanni, Azzarello, Philipp, Bene, Pierre, Bourquin, Maurice, Cristinziani, Markus, Emonet, Pascal Philippe, Extermann, Pierre, Perrin, Eric, Pohl, Martin, Produit, Nicolas, Rapin, Divic Jean, Ribordy, Mathieu, Richeux, Jean-Pierre, and Vite, Davide

Subjects
Physics, Nuclear and High Energy Physics, Earth's orbit, Range (particle radiation), 010308 nuclear & particles physics, chemistry.chemical_element, Flux, ddc:500.2, 01 natural sciences, Spectral line, Nuclear physics, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], FIS/05 - ASTRONOMIA E ASTROFISICA, FIS/01 - FISICA SPERIMENTALE, Earth's magnetic field, chemistry, 0103 physical sciences, Alpha Magnetic Spectrometer, Atomic physics, Cosmic rays: helium, Nuclear Experiment, Nucleon, 010303 astronomy & astrophysics, FIS/04 - FISICA NUCLEARE E SUBNUCLEARE, Helium
Abstract

The helium spectrum from 0.1 to 100 GeV/nucleon was measured by the Alpha Magnetic Spectrometer (AMS) during space shuttle flight STS-91 at altitudes near 380 km. Above the geomagnetic cutoff the spectrum is parameterized by a power law. Below the geomagnetic cutoff a second helium spectrum was observed. In the second helium spectra over the energy range 0.1 to 1.2 GeV/nucleon the flux was measured to be (6.3±0.9)×10 −3 ( m 2 sec sr ) −1 and more than ninety percent of the helium was determined to be 3He (at the 90% CL). Tracing helium from the second spectrum shows that about half of the 3He travel for an extended period of time in the geomagnetic field and that they originate from restricted geographic regions similar to protons and positrons.

Published
2000

19. Comparison of parameter estimation algorithms for continuous time models applied to D.C. motor thermal supervision

Author

J. P. Da Cunha, G. Champenois, J. D. Gabano, Laboratoire d'Automatique et d'Informatique Industrielle (LAII), and Université de Poitiers

Subjects
0209 industrial biotechnology, Estimation theory, Instrumental variable, Process (computing), 020206 networking & telecommunications, 02 engineering and technology, Nonlinear programming, Parameter estimation algorithm, Identification (information), 020901 industrial engineering & automation, Control theory, Thermal, 0202 electrical engineering, electronic engineering, information engineering, [INFO]Computer Science [cs], Electrical and Electronic Engineering, Equation error, Mathematics
Abstract

This paper deals with the thermal supervision of a D.C. motor process by means of parameter estimation. Identification is realized by applying two classes of algorithm to the measurable inputs/outputs of the process: The first deals with Reinitialized Partial time Moment modeling, which can be interpreted as an equation error method. The model parameters are computed by means of Least Square or Instrumental Variable algorithms. The second is based on the output error method. The model parameters are estimated by minimizing the output error by means of a Non Linear Programming according to the Marquardt algorithm.

20. Solanum linnaeanum and Solanum sisymbriifolium as a sustainable strategy for the management of Meloidogyne chitwoodi

Author

Laura Soraia Perpétuo, Maria J. M. da Cunha, Maria Teresa Batista, and Isabel Luci Conceição

Subjects
Medicine, Science
Abstract

Abstract Root-knot nematodes (RKN), Meloidogyne spp., are important crop pests that cause severe losses in crop production worldwide, reducing both productivity and crop quality. Meloidogyne chitwoodi Golden, O'Bannon, Santo & Finley, 1980 is considered a quarantine organism by the European and Mediterranean Plant Protection Organization (EPPO) causing damage in tomato and potato crops. The development of nonchemical and sustainable management strategies to reduce nematode damage is crucial. The resistance of Solanum linnaeanum Hepper & P.-M.L. Jaeger and S. sisymbriifolium Lamarck cv. Sis 6001 to M. chitwoodi was evaluated based on gall index (GI), the Bridge & Page (1980) rating chart and reproduction factor (RF). Both plant species were resistant to M. chitwoodi. Solanum linnaeanum had an average of 519 small root swellings/plant, with 45% adult nematodes inside the roots, all males. Solanum sisymbriifolium had GI ≤ 2 and RF ≤ 1 with a high percentage (69%) of nematodes inside the roots that did not develop beyond the sexually undifferentiated second-stage. The use of S. linnaeanum as a new source of resistance is a good alternative for the control of RKN in the quest to develop nonchemical and sustainable management strategies to protect crops.

Published
2021
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21. Os dias iniciais da infecção pelo vírus da gripe pandémica (H1N1) 2009 na região centro de Portugal

Author

V. Duque, E. Cordeiro, V. Mota, J. Vaz, C. Morais, F. Rodrigues, F. Coelho, J. Saraiva da Cunha, and A. Meliço-Silvestre

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Resumo: Introdução: O primeiro caso de infecção pelo vírus da gripe pandémica (H1N1) 2009 foi diagnosticado na região centro de Portugal no dia 16 de Junho de 2009, numa mulher infectada no Canadá. Métodos: O nosso estudo tem por objectivos, em primeiro lugar caracterizar os aspectos clínicos e epidemiológicos de todos os doentes que tiveram manifestações clínicas incluídas na definição de caso para investigação com amostras submetidas para diagnóstico da infecção pelo vírus da gripe pandémica (H1N1) 2009; em segundo lugar, avaliar a precisão da definição de caso para investigação de acordo com a presença ou ausência de febre no momento da observação clinica. Efectuámos a revisão dos registos médicos de todos os doentes classificados como caso para investigação e analisaram-se os primeiros casos de doentes infectados com o novo vírus da gripe pandémica (H1N1) 2009, diagnosticados na região centro de Portugal durante o período pandémico compreendido entre Junho e Agosto de 2009.Foi utilizado o método da reacção em cadeia da polimerase de retrotranscripção em tempo real para confirmação da infecção pelo vírus da gripe pandémica (H1N1) 2009. A colheita de dados foi efectuada de forma padronizada em suporte de papel de acordo com as normas da Direcçào Geral de Saúde. Resultados e discussão: A infecção pelo vírus da gripe pandémica (H1N1) 2009 foi confirmada laboratorialmente em 255 casos. A idade média foi de 23 anos e 42,7 % foram incluídos na categoria dos 20 aos 29 anos. A infecção em doentes com menos de 2 anos ou mais de 50 anos foi um acontecimiento raro. Os primeiros casos foram importados da Europa: Franca, Espanha e Inglaterra. Numa segunda fase, a infecção foi adquirida no sul de Portugal (Algarve). A taxa de incidência de infecção pelo vírus da gripe pandémica (H1N1) 2009 foi de 10,7 por 100 000 pessoas e foi diferente consoante o distrito. Foi mais elevado no distrito de Coimbra e da Guarda onde estão as principais estradas de ligação com a Europa. O período de incubação calculado para a infecção pelo vírus da gripe pandémica (H1N1) 2009 foi de 2 dias. A duração das manifestações clínicas até os doentes procurarem observação médica teve um valor mediano de 2 dias. Todos os casos foram de gravidade ligeira a moderada, sem casos de morte. Conclusões: Os dias iniciais da infecção pelo vírus da gripe pandémica (H1N1) 2009 foram caracterizados na nossa região por casos de doença com gravidade ligeira a moderada. Os mais afectados foram os jovens adultos, com as idades extremas da vida poupadas. O diagnóstico precoce, o isolamento estrito e o tratamento podem ter diminuído a disseminação da infecção. Abstract: Background: The first case of pandemic (H1N1) 2009 virus infection was diagnosed in the central region of Portugal on June 16, 2009, in a woman infected in Canada. Methods: The aim of our study was, first to characterize the clinical and epidemiologic aspects of all the patients with clinical manifestations included in the definition of case for investigation with samples submitted to diagnosis of the pandemic (H1N1) 2009 virus infection, in the central region of Portugal; second to assess the precision of the case definition of case for investigation considered in the study according to the presence or the absence of fever at the moment of clinical observation. We reviewed the medical records of all the patients presenting with Influenza like-illness classified as case for investigation and the first cases of patients infected with the new pandemic (H1N1) 2009 virus, diagnosed in the central region of Portugal during the pandemic period between June and August, 2009, were analyzed. Real-time reverse-transcriptase polymerase-chain-reaction (RT-PCR) testing was used to confirm the pandemic (H1N1) 2009 virus infection. Data collection was performed on a standardized paper format in agreement with the General Health Directorate. Results and discussion: Pandemic (H1N1) 2009 virus infection was confirmed in 255 patients. Overall, median age was 23 years and 42.7 % were included in the category of 20 to 29 years. Confirmed infection in patients with less than 2 years or greater than 50 years was a rare event. The first cases were imported from Europe, namely France, Spain and England. On a second phase, pandemic (H1N1) 2009 virus infection was acquired in the south of Portugal (Algarve), before de diagnosis of the first domestic case. The incidence rate for pandemic (H1N1) 2009 virus infection was 10.7 per 100,000 persons and was different according to the district. It was higher in the district of Coimbra and Guarda were the main roads connecting to Europe are. The median calculated incubation period for the for pandemic (H1N1) 2009 virus infection was 2 days. The length of the clinical manifestations until the patients look for medical observation had a median time of 2 days. All the cases were of mild to moderate severity. No deaths were observed. Conclusions: The early days of pandemic (H1N1) 2009 virus infection was mild in our region. Most affected patients were young adults, with the extreme categories ages of life being spared. Early detection and diagnosis, combined with stringent isolation and treatment procedures could have slowed the spread of the infection in our region. : Palavras-Chave, Gripe, Influenza, H1N1, Pandemia, 2009, Keywords: Influenza, H1N1, Pandemics, 2009

Published
2010
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