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Diminishing sea ice is impacting the wave field across the Arctic region. Recent observation and model-based studies highlight the spatiotemporal influence of sea ice on offshore wave climatologies, but effects within the nearshore region are still poorly described. This study characterizes the wave climate in the central Beaufort Sea coast from 1979 to 2019 by utilizing a wave hindcast model that uses ERA5 winds, waves, and ice concentrations as input. The spectral wave model SWAN is calibrated and validated based on more than 10,000 in situ measurements collected over a 13-year time period across the region, with friction variations and empirical coefficients for newly implemented empirical ice formulations for the open water season. Model results and trends are analyzed over the 41-year time period using the non-parametric Mann-Kendall test, including an estimate of Sen’s slope. The model results show that the reduction of sea ice concentration correlates strongly with increases in average and extreme wave conditions. In particular, the open water season extended by ~96 days over the 41-year time period (~2.4 days/yr), resulting in a five-fold increase of the yearly cumulative wave power. Moreover, the open water season extends later into the year, resulting in relatively open-water conditions during fall storms with high wind speeds. The later freeze-up results in an increase of the annual offshore median wave heights of 1 % per year and an increase in the average number of rough wave days (defined as days when maximum wave heights exceed 2.5 m) from 1.5 in 1979 to 13.1 days in 2019. Trends in the nearshore areas deviate from the patterns offshore. Model results indicate a non-breaking depth-induced saturation limit for high wave heights in the shallow areas of Foggy Island Bay. Similar patterns are found for yearly cumulative wave power.

Magnetic switchbacks are short magnetic field reversals ubiquitously observed in the solar wind. The origin of switchbacks remains an important open science question, because of switchbacks’ possible role in the heating and acceleration of the solar wind. Here, we report observations of 501 robust switchbacks, using magnetic and plasma measurements from the first eight encounters by the Parker Solar Probe. More than 46% (6%) of switchbacks are rotational (tangential; TD) discontinuities (RD), defined as magnetic discontinuities with large (small) relative normal components of magnetic field and proton velocity. Magnetic reconnection in the solar atmosphere can be a source of the observed RD-type switchbacks. It is discovered that: (1) the RD-to-TD ratio exponentially decays with increasing heliocentric distance at rate 0.06 [R S −1], and (2) TD-type switchbacks contain 64% less magnetic energy than RD-type switchbacks, suggesting that RD-type switchbacks may relax into TD-type switchbacks. It is estimated that relaxing switchbacks generated via magnetic reconnection in the solar atmosphere can transfer an additional 16% of the total reconnected magnetic energy into heating and/or accelerating the solar corona, within 11.6 [R S] of the reconnection site, below the critical Alfvén surface.

Staphylococcus aureus is a foremost bacterial pathogen responsible for a vast array of human diseases. Staphylococcal superantigens (SAgs) constitute a family of potent exotoxins secreted by S. aureus, and SAg genes are found ubiquitously in human isolates. SAgs bind directly to MHC class II molecules and T cell receptors, driving extensive T cell activation and cytokine release. Although these toxins have been implicated in serious disease including toxic shock syndrome, we aimed to further elucidate the mechanisms by which SAgs contribute to staphylococcal pathogenesis during septic bloodstream infections. As most conventional mouse strains respond poorly to staphylococcal SAgs, we utilized transgenic mice encoding humanized MHC class II molecules (HLA-DR4) as these animals are much more susceptible to SAg activity. Herein, we demonstrate that SAgs contribute to the severity of S. aureus bacteremia by increasing bacterial burden, most notably in the liver. We established that S. aureus bloodstream infection severity is mediated by CD4+ T cells and interferon-gamma (IFNγ) is produced to very high levels during infection in a SAg-dependent manner. Bacterial burden and disease severity were reduced by antibody blocking of IFNγ, phenocopying isogenic SAg deletion mutant strains. Additionally, cytokine analysis demonstrated that the immune system was skewed towards a proinflammatory response that was reduced by IFNγ blocking. Infection kinetics and flow cytometry analyses suggested this was a macrophage driven mechanism, which was confirmed through macrophage depletion experiments. Further validation with human leukocytes indicated that excessive IFNγ allowed S. aureus to replicate at a higher rate within macrophages. Together, this suggests that SAgs promote S. aureus survival by manipulating immune responses that would otherwise be effective at clearing S. aureus. This work implicates SAg toxins as critical targets for preventing persistent or severe S. aureus disease.

This paper presents the results of a multifaceted study of the behavior of a novel hydrokinetic energy harvester that utilizes vertical oscillations. Unlike traditional rotating turbines used in hydrokinetic energy, this particular device utilizes the fluid structure interactions of vortex-induced-vibration and gallop. Due to the unique characteristics of this vertical motion, a thorough examination of the proposed system was conducted via a three-pronged approach of simulation, emulation, and field testing. Using a permanent magnet synchronous generator as the electrical power generation source, an electrical power conversion system was simulated, emulated, and tested to achieve appropriate power smoothing for use in microgrid systems present in many Alaskan rural locations.

The heat recovery efficiency of ventilation systems utilizing heat recovery ventilators (HRVs) depends not only on the heat recovery efficiency of the HRV units themselves but also on the intake and exhaust ducts that connect the HRV units to the outside environment. However, these ducts are often neglected in heat loss calculations, as their impact on the overall heat recovery efficiency of HRV systems is often not understood and, to the knowledge of the authors, a mathematical model for the overall heat recovery efficiency of HRV systems that accounts for these ducts has not been published. In this research, a mathematical model for the overall heat recovery efficiency of HRV systems that accounts for the intake and exhaust ducts was derived and validated using real-life data. The model-predicted decrease in heat recovery efficiency due to the ducts was in reasonable agreement (relative error within 20%) with the real-life measurements. The results suggest that utilizing this model allows for more correct ventilation heat loss calculations compared to using the heat recovery efficiency of the HRV unit alone, but more field studies are needed to verify the accuracy of this model in a wide range of applications.

Purpose The field of online monitoring of the beam range is one of the most researched topics in proton therapy over the last decade. The development of detectors that can be used for beam range verification under clinical conditions is a challenging task. One promising possible solution are modalities that record prompt-gamma radiation produced by the interactions of the proton beam with the target tissue. A good understanding of the energy spectra of the prompt gammas and the yields in certain energy regions is crucial for a successful design of a prompt-gamma detector. Monte-Carlo simulations are an important tool in development and testing of detector concepts, thus the proper modelling of the prompt-gamma emission in those simulations are of vital importance. In this paper, we confront a number of GEANT4 simulations of prompt-gamma emission, performed with different versions of the package and different physics lists, with experimental data obtained from a phantom irradiation with proton beams of four different energies in the range 70–230 MeV. Methods The comparison is made on different levels: features of the prompt-gamma energy spectrum, gamma emission depth profiles for discrete transitions and the width of the distal fall-off in those profiles. Results The best agreement between the measurements and the simulations is found for the GEANT4 version 10.4.2 and the reference physics list QGSP_BIC_HP. Conclusions Modifications to prompt-gamma emission modelling in higher versions of the software increase the discrepancy between the simulation results and the experimental data.

Properties of different scintillating fibers were examined and compared, as a part of the design optimization of the SiFi-CC detector, currently under development for proton therapy monitoring. Three scintillating materials were considered as candidates to constitute the active part of the detector: LYSO:Ce, LuAG:Ce and GAGG:Ce. All investigated samples had an elongated, fiber-like shape and were read out on both ends using silicon photomultipliers (SiPMs). Samples of LYSO:Ce material provided by four different manufacturers were included in the survey. Additionally, different types of optical coupling media, wrapping and coating materials were investigated. The following properties of the scintillating fibers were determined: attenuation length, position-, energy-, timing resolution and light collection. Two models were used to describe the propagation of scintillating light in the fiber and quantify the light attenuation: exponential light attenuation model (ELA) and exponential light attenuation model with light reflection (ELAR). Energy and position reconstruction were also performed using the two above methods. It was shown, that the ELAR model performs better in terms of description of the light attenuation process. However, energy and position reconstruction results are comparable for the two proposed methods. Based on the results of measurements with scintillating fibers in different configurations we concluded that LYSO:Ce fibers wrapped in Al foil (bright side facing towards the fiber) provided the best trade-off between the energy- (8.56% at 511 keV) and position (32 mm) resolutions and thus will be the optimal choice for the SiFi-CC detector. Additionally, the study of different optical coupling media showed, that the silicone pads coupling ensures good stability of the system performance and parameters.

Multiple sclerosis treatment options are increasing. Evidence-based patient information (EBPI) are therefore crucial to enable patient involvement in decision making. Based on earlier work on decision support, patient information handbooks on 8 MS immunotherapies were developed, piloted and evaluated with support from the German Clinical Competence Network MS and the German MS Society.Handbooks were structured according to EBPI concepts. Drafts were commented by patient representatives and neurologists with an MS expertise. Executive boards of the German MS Society and the Competence Network as well as pharmaceutical companies' feedback was included. Handbooks were distributed among MS neurologists by the German MS Society. Evaluation followed applying a mixed methods approach with interviews, focus groups and surveys. One survey addressed persons with MS (pwMS) based on a questionnaire included in each handbook. Neurologists who received printed patient handbooks were invited to give feedback in a second survey.Eight handbooks were developed providing absolute and relative risk information in numbers and figures as well as monitoring needs and drug fact boxes. Despite the high amount of information and the display of low absolute risk reduction rates of treatments, handbooks were overall appreciated by pwMS (n=107) and mostly also by physicians (n=24). For more than 70% of the pwMS the information was new, understandable and supportive for decision making. But patients felt uncomfortable with relative risk information. However, response rates in the evaluation were low, exposing the challenges when implementing EBPI into clinical care. Therefore, conclusions must be considered preliminary.EBPI on immunotherapies for MS seem feasible and are appreciated by patients and treating neurologists but more implementation research is needed.

The re-emergence of scarlet fever poses a new global public health threat. The capacity of North-East Asian serotype M12 (emm12) Streptococcus pyogenes (group A Streptococcus, GAS) to cause scarlet fever has been linked epidemiologically to the presence of novel prophages, including prophage ΦHKU.vir encoding the secreted superantigens SSA and SpeC and the DNase Spd1. Here, we report the molecular characterization of ΦHKU.vir-encoded exotoxins. We demonstrate that streptolysin O (SLO)-induced glutathione efflux from host cellular stores is a previously unappreciated GAS virulence mechanism that promotes SSA release and activity, representing the first description of a thiol-activated bacterial superantigen. Spd1 is required for resistance to neutrophil killing. Investigating single, double and triple isogenic knockout mutants of the ΦHKU.vir-encoded exotoxins, we find that SpeC and Spd1 act synergistically to facilitate nasopharyngeal colonization in a mouse model. These results offer insight into the pathogenesis of scarlet fever-causing GAS mediated by prophage ΦHKU.vir exotoxins., The pathogenesis of Streptococcus pyogenes (GAS) causing scarlet fever has been associated with the presence of prophages, such as ΦHKU.vir, and their products. Here, the authors characterize the exotoxins SpeC and Spd1 of ΦHKU.vir and show these to act synergistically to facilitate nasopharyngeal colonization in mice.

The re-emergence of scarlet fever poses a new global public health threat. The capacity of North-East Asian serotype M12 (emm12) Streptococcus pyogenes (group A Streptococcus, GAS) to cause scarlet fever has been linked epidemiologically to the presence of novel prophages, including prophage ΦHKU.vir encoding the secreted superantigens SSA and SpeC and the DNase Spd1. Here we report the comprehensive molecular characterization of ΦHKU.vir-encoded exotoxins. We demonstrate that streptolysin O (SLO)-induced glutathione efflux from host cellular stores is a previously unappreciated GAS virulence mechanism that promotes SSA release and activity, representing the first description of a thiol-activated bacterial superantigen. Spd1 is required for optimal growth in human blood, confers resistance to neutrophil killing, and degrades neutrophil extracellular traps (NETs). Investigating single, double and triple isogenic knockout mutants of the ΦHKU.vir-encoded exotoxins, we find that SpeC and Spd1 act synergistically to facilitate nasopharyngeal colonization in a mouse model. These results offer insight into the etiology and pathogenesis of scarlet fever-causing GAS mediated by phage ΦHKU.vir exotoxins.

Integration of renewable power sources into grids remains an active research and development area, particularly for less developed renewable energy technologies such as wave energy converters (WECs). WECs are projected to have strong early market penetration for remote communities, which serve as natural microgrids. Hence, accurate wave predictions to manage the interactions of a WEC array with microgrids is especially important. Recently developed, low-cost wave measurement buoys allow for operational assimilation of wave data at remote locations where real-time data have previously been unavailable. This work includes the development and assessment of a wave modeling framework with real-time data assimilation capabilities for WEC power prediction. The availability of real-time wave spectral components from low-cost wave measurement buoys allows for operational data assimilation with the Ensemble Kalman filter technique, whereby measured wave conditions within the numerical wave forecast model domain are assimilated onto the combined set of internal and boundary grid points while taking into account model and observation error covariances. The updated model state and boundary conditions allow for more accurate wave characteristic predictions at the locations of interest. Initial deployment data indicated that measured wave data from one buoy that were assimilated into the wave modeling framework resulted in improved forecast skill for a case where a traditional numerical forecast model (e.g., Simulating WAves Nearshore; SWAN) did not well represent the measured conditions. On average, the wave power forecast error was reduced from 73% to 43% using the data assimilation modeling with real-time wave observations.

One of the big challenges for proton therapy is the development of tools for online monitoring of the beam range, which are suited to operate in clinical conditions and can be included in the clinical practice. A Compton camera based on stacks of heavy scintillating fibers used for prompt-gamma imaging is a promising approach for this task. It provides full, three-dimensional information on the deposited dose distribution while showing a high detection efficiency and rate capability due to its high granularity. The investigation of the rate capability and detection efficiency of such a camera under clinical conditions by means of Geant4 simulations is presented along with the event construction algorithm. The results hint towards a very low pile-up rate in the detector and a relatively high detection efficiency, so that imaging of a single proton beam spot appears to be an achievable goal.

The globally prominent pathogen Streptococcus pyogenes secretes potent immunomodulatory proteins known as superantigens (SAgs), which engage lateral surfaces of major histocompatibility class II molecules and T-cell receptor (TCR) β-chain variable domains (Vβs). These interactions result in the activation of numerous Vβ-specific T cells, which is the defining activity of a SAg. Although streptococcal SAgs are known virulence factors in scarlet fever and toxic shock syndrome, mechanisms by how SAgs contribute to the life cycle of S. pyogenes remain poorly understood. Herein, we demonstrate that passive immunization against the Vβ8-targeting SAg streptococcal pyrogenic exotoxin A (SpeA), or active immunization with either wild-type or a nonfunctional SpeA mutant, protects mice from nasopharyngeal infection; however, only passive immunization, or vaccination with inactive SpeA, resulted in high-titer SpeA-specific antibodies in vivo. Mice vaccinated with wild-type SpeA rendered Vβ8+ T cells poorly responsive, which prevented infection. This phenotype was reproduced with staphylococcal enterotoxin B, a heterologous SAg that also targets Vβ8+ T cells, and rendered mice resistant to infection. Furthermore, antibody-mediated depletion of T cells prevented nasopharyngeal infection by S. pyogenes, but not by Streptococcus pneumoniae, a bacterium that does not produce SAgs. Remarkably, these observations suggest that S. pyogenes uses SAgs to manipulate Vβ-specific T cells to establish nasopharyngeal infection.

While examining the therapeutic value of anti-CD52 antibody against EAE/MS, we identified a unique subset of CD39+ Tregs in repopulating GALT tissues, a major lymphoid reservoir, which was accompanied by amelioration of disease. Furthermore, anti-CD52 treatment leads to increased expression of BDNF, IL-10, and SMAD3 in the brains of EAE mice. This condition is associated with suppression of IL-17, a critical inflammatory factor in EAE/MS progression. Additionally, we found elevated levels of CD4+CD39+ Tregs in PBMCs of RRMS patients treated with humanized anti-CD52 mAb. Thus, anti-CD52 can affect multiple immune mediated pathways involved in the pathogenesis of EAE/MS.

Recent development in the production of inorganic scintillators resulted in a variety of materials, many of which show excellent timing properties and large light yield. Due to large densities and effective atomic numbers, those materials are well suited for detection of a-few-MeV prompt gamma radiation, which is emitted during hadron therapy. Additionally, when combined with modern silicon photomultipliers (SiPM), they allow compact and granular detector designs. Therefore, heavy scintillators seem to be promising candidates for prompt gamma imaging (PGI) detectors, such as Compton cameras. Under the SiFi-CC (SiPM and Fiber based Compton Camera) project the investigation of heavy scintillating materials for their application in hadron therapy monitoring has been carried out. The study was focused on lutetium based crystals, including LuAG:Ce and LYSO:Ce as well as recently developed GAGG:Ce,Mg. Examined samples had an elongated, fiber-like shape, with 100 mm length and 1 × 1 mm2 square cross section. The following features of such fibers were investigated: attenuation length of the optical photons, light yield, energy resolution and timing characteristics. The study has shown that out of the materials chosen for the study LYSO:Ce is the most promising candidate for applications in PGI. Additionally, in order to optimize performance of scintillators an influence of wrapping was investigated. It has been observed that aluminum wrapping causes an increase in the light yield, but decreases the attenuation length.

BackgroundInjection drug use-associated endocarditis (IDUaIE) incidence in Ontario has recently been associated with hydromorphone prescribing rates. Staphylococcus aureus causes the majority of cases of IDUaIE in Ontario and across North America. Hydromorphone controlled-release (Hydromorphone-CR) requires a complex technique for injection and therefore provides multiple opportunities for contamination. Hydromorphone-CR contains several excipients, which could enhance staphylococcal survival and increase risk of contaminating the injectate.MethodsUsed injection drug preparation equipment (cookers/filters) was collected from persons who inject drugs (PWID), rinsed with water, and plated on Mannitol salt agar. Bacterial isolates from bacteremic PWID were used to assess the survival of S. aureus and Streptococcus pyogenes on cookers/filters with Hydromorphone-CR, hydromorphone immediate-release (Hydromorphone-IR) or oxycodone controlled-release (Oxycodone-CR). The solutions spiked with S. aureus were heated and the remaining viable bacteria enumerated.ResultsS. aureus was detected in 12/87 (14%, 95%CI 8-23%) cookers/filters samples used for injection of Hydromorphone-CR. Hydromorphone-CR was the only opioid associated with greater survival of methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) on cookers/filters when compared to sterile water vehicle control. There was a ~2 log reduction in the number of S. aureus that survived when cookers/filters were heated.Conclusion14% of all cookers/filters used in the preparation of Hydromorphone-CR were contaminated with S. aureus. Hydromorphone-CR prolongs the survival of MRSA and MSSA in cookers/filters. Heating cookers/filters may be a harm-reduction strategy.

Data from a five-mooring array extending from the inner shelf to the continental slope in the vicinity of Mackenzie Canyon, Beaufort Sea are analyzed to elucidate the components of the boundary current system and their variability. The array, part of the Marine Arctic Ecosystem Study (MARES), was deployed from October 2016 to September 2017. Four distinct currents were identified: an eastward-directed flow adjacent to the coast; a westward-flowing, surface-intensified current centered on the outer-shelf; a bottom-intensified shelfbreak jet flowing to the east; and a recirculation at the base of the continental slope within the canyon. The shelf current transports −0.12 ± 0.03 Sv in the mean and is primarily wind-driven. The response is modulated by the presence of ice, with little-to-no signal during periods of nearly-immobile ice cover and maximum response when there is partial ice cover. The shelfbreak jet transports 0.03 ± 0.02 Sv in the mean, compared to 0.08 ± 0.02 Sv measured upstream in the Alaskan Beaufort Sea over the same time period. The loss of transport is consistent with a previous energetics analysis and the lack of Pacific-origin summer water downstream. The recirculation in the canyon appears to be the result of local dynamics whereby a portion of the westward-flowing southern limb of the Beaufort Gyre is diverted up the canyon across isobaths. This interpretation is supported by the fact that the low-frequency variability of the recirculation is correlated with the wind-stress curl in the Canada Basin, which drives the Beaufort gyre.

The next awaited breakthrough in proton therapy is the inclusion of the tools for online monitoring of beam range into clinical practice. Full, three-dimensional information on the deposited dose distribution can be obtained by means of prompt gamma imaging using Compton cameras. Large gamma detection efficiency and high-rate capacity can be achieved using detectors of high granularity made of a heavy scintillator. One of the possible design options is a stack of scintillating fibers. As the overall performance of such a camera depends on the position, time and energy resolution of the fibers, we investigate those properties both experimentally in measurements with a test bench as well as via Monte Carlo simulations. The obtained results point at LYSO:Ce as the best candidate for a sensitive material of a Compton camera of the discussed type.

Motor activity of boys (age 8-12 years) with (n=19) and without (n=18) ADHD was objectively measured with actigraphy across experimental conditions that varied with regard to demands on executive functions. Activity exhibited during two n-back (1-back, 2-back) working memory tasks was compared to activity during a choice-reaction time (CRT) task that placed relatively fewer demands on executive processes and during a simple reaction time (SRT) task that required mostly automatic processing with minimal executive demands. Results indicated that children in the ADHD group exhibited greater activity compared to children in the non-ADHD group. Further, both groups exhibited the greatest activity during conditions with high working memory demands, followed by the reaction time and control task conditions, respectively. The findings indicate that large-magnitude increases in motor activity are predominantly associated with increased demands on working memory, though demands on non-executive processes are sufficient to elicit small to moderate increases in motor activity as well.

Superantigens (SAgs) are potent microbial toxins that function to activate large numbers of T cells in a T cell receptor (TCR) Vβ-specific manner, resulting in excessive immune system activation. Staphylococcus aureus possesses a large repertoire of distinct SAgs, and in the context of host-pathogen interactions, staphylococcal SAg research has focused primarily on the role of these toxins in severe and invasive diseases. However, the contribution of SAgs to colonization by S. aureus remains unclear. We developed a two-week nasal colonization model using SAg-sensitive transgenic mice expressing HLA-DR4, and evaluated the role of SAgs using two well-studied stains of S. aureus. S. aureus Newman produces relatively low levels of staphylococcal enterotoxin A (SEA), and although we did not detect significant TCR-Vβ specific changes during wild-type S. aureus Newman colonization, S. aureus Newman Δsea established transiently higher bacterial loads in the nose. S. aureus COL produces relatively high levels of staphylococcal enterotoxin B (SEB), and colonization with wild-type S. aureus COL resulted in clear Vβ8-specific T cell skewing responses. S. aureus COL Δseb established consistently higher bacterial loads in the nose. These data suggest that staphylococcal SAgs may be involved in regulating bacterial densities during nasal colonization.

Dieser Artikel berichtet uber die Ergebnisse eines uber zwei Jahre durchgefuhrten wissenschaftlichen Projekts. Der Fokus lag bei diesem Projekt auf der Untersuchung der rheologischen Eigenschaften und dem Abbindeverhalten von Feuerbetonen in Abhangigkeit von Mischenergie im trocknen und nassen Zustand. Die richtige Einstellung der Mischzeit und -geschwindigkeit auch vor der Wasserzugabe ist eine wirksame Masnahme zur Forderung des Verdichtungsverhaltens der Feuerbetone. Die Produkte weisen eine erhohte Homogenitat sowie verbesserte Eigenschaften im Besonderen mit Hinblick auf Rheologie, Dichte, offener Porositat und mechanischer Festigkeit auf. Die viel versprechenden Ergebnisse zeigen andererseits, dass die Beurteilung von Entwicklungs- und Forschungsergebnissen vermehrt in qualitativer Hinsicht erfolgen sollte Gegenwartig wird die Aufbereitungsroutine von Feuerbetonen in Forschungs- und Entwicklungsarbeiten nicht klar kommuniziert. Das Mischverfahren muss unerlasslicher Teil der Beschreibung des Herstellungsverfahrens werden. Kunftige Entwicklung von Feuerbetonen werden sich konsequenter als bisher auf die Optimierung der Partikelgrosenverteilung mikrofeiner Komponenten fokussieren, um so Erzeugnisse mit verbesserter Haltbarkeit im Betrieb herstellen zu konnen. Durch diese zunehmend komplexere Gestaltung von Feuerbetonen, werden die Anforderungen an eine umfassende Homogenisierung bedeutend ansteigen. Fur eine einwandfreie Deagglomeration ohne unerwunschte Erwarmung der Mischung und daraus resultierenden kurzeren Verarbeitungszeiten ist es daher notwendig, die optimale Mischenergie eines Feuerbetons festzulegen. Wie bereits von vielen Autoren berichtet wurde, ist die Abbindegeschwindigkeit von Zement-Wasser-Suspensionen in der gewunschten Genauigkeit nicht vorhersehbar. Als Nebeneffekt des genannten Projekts kann gezeigt werden, dass der Beginn der Kristallisation der Zement-Hydrat-Phasen, welche mit dem Abbinden der Wasser-Zement-Suspension in einer Wechselbeziehung steht, in starker Abhangigkeit zur Mischenergie steht. Der Beginn des Temperaturanstiegs und die Charakteristik der Temperaturentwicklung, steht in direktem Zusammenhang mit dem Deagglomerationsgrad der Zementpartikel, welcher durch den Mischvorgang erreicht werden kann.

Idealized numerical simulations using the Regional Ocean Modeling System demonstrate the effects of an immobile landfast ice cover that is frictionally coupled to an underice buoyant plume established by river discharge. The discharge rapidly increases and decreases over a 30-day period and has a maximum of 6000 m3 s−1. This study examined the response to a landfast ice cover of 26-km width and one that encompasses the entire shelf width. The model setting mimics spring conditions on the Alaskan Beaufort Sea (ABS) shelf. In comparison with the ice-free case subject to the same discharge scenario, underice plumes are broader and deeper, and the downwave freshwater flux is substantially decreased and delayed. Multiple anticyclonic bulges form in the ice-free case, but only a single, large bulge forms when ice is present. These differences are because of the frictional coupling between the ice and plume, which results in an Ekman-like underice boundary layer, a subsurface velocity maximum, and frictional shears that enhance vertical mixing and entrainment. For a partially ice-covered shelf, the plume spreads across the ice edge to form a swift, buoyant, ice-edge jet, whose width accords with the scale of Yankovsky and Chapman for a surface-advected plume. For a fully ice-covered shelf, the buoyant water spreads 60 km offshore over a 30-day period. For a steady discharge of 6000 m3 s−1 and a completely ice-covered shelf, the plume spreads offshore at a rate of ~1.5 km day−1 and extends ~95 km offshore after 60 days.

This paper reports on the results of a science project conducted during the last two years. In this project a focus was set on the rheological and setting properties as a function of the mixing energy applied in dry and wet state. A proper adjustment of mixing time and velocity even prior to the water addition is a powerful measure to enhance the compaction properties of concretes. The products are more homogenous and show improved properties with special regard to their rheology, density, open porosity and mechanical strength. On the other hand, these encouraging results depict that results in development and research work should be read in a more qualitative way unless the preparation routine of test specimen are clearly communicated. It has to be proposed, that the mixing procedure should be an indispensable part of the procedure description. Future developments of refractory castables will even focus more consequently on the design of the particle distribution of the micro fine components in order to produce products with enhanced durability in service. However, if the matrix design turns more complex the requirements for a perfect homogenization increase exceptionally. It is necessary to define the optimum mixing energy for a proper deagglomeration without an unwanted warming of the mix that will lead to shorter pot times. As reported by many authors the setting velocity of plain cement-water suspensions is not predictable in a wanted correctness. As a spinoff of the said project, it can be shown, that the starting time of the crystallization of cement hydrate phases that correlates with the setting of the water cement suspensions is strongly dependent on the mixing energy. The starting time of the temperature increases and the distinct slope of the temperature evolution is a function of the deagglomeration degree of the cement particles during mixing.

The gut microbiome plays an important role in the development of inflammatory disease as shown using experimental models of central nervous system (CNS) demyelination. Gut microbes influence the response of regulatory immune cell populations in the gut-associated lymphoid tissue (GALT), which drive protection in acute and chronic experimental autoimmune encephalomyelitis (EAE). Recent observations suggest that communication between the host and the gut microbiome is bidirectional. We hypothesized that the gut microbiota differs between the acute inflammatory and chronic progressive stages of a murine model of secondary-progressive multiple sclerosis (SP-MS). This non-obese diabetic (NOD) model of EAE develops a biphasic pattern of disease that more closely resembles the human condition when transitioning from relapsing-remitting (RR)-MS to SP-MS. We compared the gut microbiome of NOD mice with either mild or severe disease to that of non-immunized control mice. We found that the mice which developed a severe secondary form of EAE harbored a dysbiotic gut microbiome when compared with the healthy control mice. Furthermore, we evaluated whether treatment with a cocktail of broad-spectrum antibiotics would modify the outcome of the progressive stage of EAE in the NOD model. Our results indicated reduced mortality and clinical disease severity in mice treated with antibiotics compared with untreated mice. Our findings support the hypothesis that there are reciprocal effects between experimental CNS inflammatory demyelination and modification of the microbiome providing a foundation for the establishment of early therapeutic interventions targeting the gut microbiome that could potentially limit disease progression.

We present experimental investigation of cross sections for processes crucial in view of prompt-gamma imaging. The prompt-gamma rays were produced from an interaction of a proton beam with different phantom materials composed of carbon, oxygen and hydrogen. The used target setup allowed precise selection of the investigated depth in the phantom. We studied details of the dependence of prompt-gamma yields on beam energy, detection angle and elemental composition of irradiated phantom. The analysis was focused on the discrete transitions with the largest cross sections: 4.44 MeV in 12C and 6.13 MeV in 16O. The results are presented in form of profiles of the prompt-gamma yield as a function of depth. They are compared to calculations including different cross-section models. Obtained results are in agreement with the model exploiting cross-section data collected from the literature, but the comparison with the TALYS model shows discrepancies. In the latest experiment, special attention was paid to the shape of the distal fall-off. The width of that fall-off is directly linked to the resolution of prompt-gamma based methods of range verification. Preliminary results on the beam-energy dependence of this quantity are presented.