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2. Generative Adversarial Networks for Scintillation Signal Simulation in EXO-200.

Author

S. Li, I. Ostrovskiy, Z. Li, L. Yang, S. Al Kharusi, G. Anton, I. Badhrees, P. S. Barbeau, D. Beck, V. Belov, T. Bhatta, M. Breidenbach, T. Brunner, G. F. Cao, W. R. Cen, C. Chambers, B. Cleveland, M. Coon, A. Craycraft, T. Daniels, L. Darroch, S. J. Daugherty, J. Davis, S. Delaquis, A. Der Mesrobian-Kabakian, R. DeVoe, J. Dilling, A. Dolgolenko, M. J. Dolinski, J. Echevers, W. Fairbank Jr., D. Fairbank, J. Farine, S. Feyzbakhsh, P. Fierlinger, Y. S. Fu, D. Fudenberg, P. Gautam, R. Gornea, G. Gratta, C. Hall, E. V. Hansen, J. Hoessl, P. Hufschmidt, M. Hughes, A. Iverson, A. Jamil, C. Jessiman, M. J. Jewell, A. Johnson, A. Karelin, L. J. Kaufman, T. Koffas, R. Krücken, A. Kuchenkov, K. S. Kumar, Y. Lan, A. Larson, B. G. Lenardo, D. S. Leonard, G. S. Li, C. Licciardi, Y. H. Lin, R. MacLellan, T. McElroy, T. Michel, B. Mong, D. C. Moore, K. Murray, O. Njoya, O. Nusair, A. Odian, A. Perna, A. Piepke, A. Pocar, F. Retière, A. L. Robinson, P. C. Rowson, J. Runge, S. Schmidt, D. Sinclair, K. Skarpaas, A. K. Soma, V. Stekhanov, M. Tarka, S. Thibado, J. Todd, T. Tolba, T. I. Totev, and R. Tsang

Published
2023
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3. Combined Bluntness and Roughness Effects on Cones at Hypersonic Speeds

Author

P Paredes, A Scholten, M Choudhari, F Li, B Prince, and J Jewell

Subjects
Aerodynamics
Abstract

This computational study investigates the effects of discrete roughness elements on a blunt cone at zero degrees angle of attack in a Mach 6 flow. Motivation was provided by experiments conducted in the Air Force Research Laboratory Mach 6 High Reynolds Number facility on a 7-degree half-angle cone with a roughness array located at 45 degrees from the apex on two nose tips of different blutness but equivalent roughness Reynolds number. Transition was only affected on the blunter cone, indicating that the transition onset is associated with the combined effects of bluntness and roughness. The present study investigates the 15.24 mm nose radius, 420 azimuthal wavenumber case via Navier-Stokes computations of the laminar base flow and instability analysis. Plane-marching parabolized stability equations (PSE) and inflow-resolvent analysis based on the three-dimensional, harmonic linearized Navier-Stokes equations (HLNSE) are used to calculate the amplification of disturbances along the roughness wake as well as over the roughness nearfield. Results show that the roughness shape can have a great impact on the characteristics of the most amplified wake instabilities. For the experimental configuration with cubic roughness elements of 15 μm height, the flow is marginally unstable. For prismatic elements of 20 μm height, the PSE predicts a logarithmic disturbance amplification ratio of N = 5.6 along its wake, but this ratio increases to N = 9.6 when the amplification over the roughness and separation regions is included in the inflow-resolvent analysis.

Published
2022
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4. Boundary Layer Instabilities Over a Cone-Cylinder-Flare Model at Mach 6

Author

P Paredes, A Scholten, M Choudhari, F Li, E Benitez, and J Jewell

Subjects
Aerodynamics
Abstract

Computations are performed to investigate the boundary-layer instabilities over a sharp cone-cylinder-flare model at zero degrees angle of attack. The model geometry and the flow conditions are selected to match the experiments conducted in the Boeing/AFOSR Mach 6 Quiet Tunnel (BAM6QT) at Purdue University. The geometry consists of a nominally sharp 5-degree half-angle cone, followed by a cylindrical segment and then a 10-degree flare. An axisymmetric separation bubble is generated as a result of the laminar shock/boundary-layer interaction in the cylinder-flare region. The comparison of the laminar flow solution and the schlieren images shows a remarkable agreement between the respective locations of both the boundarylayer edge and the reattachment shock. The predicted heat flux distribution is also in agreement with the measured values downstream of the reattachment location. The analysis of convective and global instabilities is performed for flare half angles equal to 8, 10, and 12 degrees and nosetip radii equal to 0.1, 1, and 5 mm. The linear amplification of first and second Mack mode instabilities that begin to amplify in the cone region are computed with a combination of the parabolized stability equations (PSE) and the harmonic linearized Navier-Stokes equations (HLNSE). The predicted frequency spectra of the surface pressure fluctuations associated with both planar and oblique instability waves are compared with the measured spectra at the various locations of the PCB and Kulite sensors. The comparison shows that the computational analysis captures the distinct lobes within the disturbance amplification spectra measured in the experiments, but some differences in amplification characteristics are noted at low frequencies. Overall, the oblique disturbances are found to be more amplified than the planar disturbances. To our knowledge, this represents the first successful comparison between convective instability analysis and measured surface pressure fluctuations for a hypersonic configuration with a separation bubble. Finally, the global instability analysis shows that the laminar flow becomes supercritical for flare half angles larger than 8 degrees. The unstable global mode for the experimental configuration of a 10 degrees flare and a sharp nosetip cone corresponds to a stationary three-dimensional disturbance that is concentrated in the recirculation region and achieves its maximum growth rate for an azimuthal wavenumber of 5.

Published
2022
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5. Inequalities in education and national income are associated with poorer diet: Pooled analysis of individual participant data across 12 European countries.

Author

H L Rippin, J Hutchinson, D C Greenwood, J Jewell, J J Breda, A Martin, D M Rippin, K Schindler, P Rust, S Fagt, J Matthiessen, E Nurk, K Nelis, M Kukk, H Tapanainen, L Valsta, T Heuer, E Sarkadi-Nagy, M Bakacs, S Tazhibayev, T Sharmanov, I Spiroski, M Beukers, C van Rossum, M Ocke, A K Lindroos, Eva Warensjö Lemming, and J E Cade

Subjects
Medicine, Science
Abstract

BACKGROUND:Malnutrition linked to noncommunicable diseases presents major health problems across Europe. The World Health Organisation encourages countries to conduct national dietary surveys to obtain data to inform public health policies designed to prevent noncommunicable diseases. METHODS:Data on 27334 participants aged 19-64y were harmonised and pooled across national dietary survey datasets from 12 countries across the WHO European Region. Weighted mean nutrient intakes were age-standardised using the Eurostat 2013 European Standard Population. Associations between country-level Gross Domestic Product (GDP) and key nutrients and nutrient densities were investigated using linear regression. The potential mitigating influence of participant-level educational status was explored. FINDINGS:Higher GDP was positively associated with total sugar intake (5·0% energy for each 10% increase in GDP, 95% CI 0·6, 9·3). Scandinavian countries had the highest vitamin D intakes. Participants with higher educational status had better nutritional intakes, particularly within lower GDP countries. A 10% higher GDP was associated with lower total fat intakes (-0·2% energy, 95% CI -0·3, -0·1) and higher daily total folate intakes (14μg, 95% CI 12, 16) in higher educated individuals. INTERPRETATION:Lower income countries and lower education groups had poorer diet, particularly for micronutrients. We demonstrate for the first time that higher educational status appeared to have a mitigating effect on poorer diet in lower income countries. It illustrates the feasibility and value of harmonising national dietary survey data to inform European policy regarding access to healthy diets, particularly in disadvantaged groups. It specifically highlights the need for strong policies supporting nutritional intakes, prioritising lower education groups and lower income countries.

Published
2020
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7. Search for Majoron-emitting modes of Xe136 double beta decay with the complete EXO-200 dataset

Author

S. Al Kharusi, G. Anton, I. Badhrees, P. S. Barbeau, D. Beck, V. Belov, T. Bhatta, M. Breidenbach, T. Brunner, G. F. Cao, W. R. Cen, C. Chambers, B. Cleveland, M. Coon, A. Craycraft, T. Daniels, L. Darroch, S. J. Daugherty, J. Davis, S. Delaquis, A. Der Mesrobian-Kabakian, R. DeVoe, J. Dilling, A. Dolgolenko, M. J. Dolinski, J. Echevers, W. Fairbank, D. Fairbank, J. Farine, S. Feyzbakhsh, P. Fierlinger, D. Fudenberg, P. Gautam, R. Gornea, G. Gratta, C. Hall, E. V. Hansen, J. Hoessl, P. Hufschmidt, M. Hughes, A. Iverson, A. Jamil, C. Jessiman, M. J. Jewell, A. Johnson, A. Karelin, L. J. Kaufman, T. Koffas, R. Krücken, A. Kuchenkov, K. S. Kumar, Y. Lan, A. Larson, B. G. Lenardo, D. S. Leonard, G. S. Li, S. Li, Z. Li, C. Licciardi, Y. H. Lin, R. MacLellan, T. McElroy, T. Michel, B. Mong, D. C. Moore, K. Murray, O. Njoya, O. Nusair, A. Odian, I. Ostrovskiy, A. Perna, A. Piepke, A. Pocar, F. Retière, A. L. Robinson, P. C. Rowson, D. Ruddell, J. Runge, S. Schmidt, D. Sinclair, K. Skarpaas, A. K. Soma, V. Stekhanov, M. Tarka, S. Thibado, J. Todd, T. Tolba, T. I. Totev, R. Tsang, B. Veenstra, V. Veeraraghavan, P. Vogel, J.-L. Vuilleumier, M. Wagenpfeil, J. Watkins, M. Weber, L. J. Wen, U. Wichoski, G. Wrede, S. X. Wu, Q. Xia, D. R. Yahne, L. Yang, Y.-R. Yen, O. Ya. Zeldovich, and T. Ziegler

Subjects
010308 nuclear & particles physics, 0103 physical sciences, 010306 general physics, 01 natural sciences
Published
2021

8. Searching for dark photons with existing haloscope data

Author

M. J. Jewell, A. Leder, Reina H. Maruyama, Sumita Ghosh, and E. P. Ruddy

Subjects
Physics, Particle physics, Photon, 010308 nuclear & particles physics, Physics::Optics, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, High Energy Physics - Experiment, High Energy Physics - Phenomenology, High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), 0103 physical sciences, 010306 general physics
Abstract

The dark (or hidden) photon is a massive U(1) gauge boson theorized as a dark force mediator and as a dark matter candidate. Dark photons can be detected with axion cavity haloscopes by probing for a power excess caused by the dark photon's kinetic mixing with Standard Model photons. Haloscope axion exclusion limits may therefore be converted into competitive dark photon parameter limits via the calculation of a corresponding dark photon to photon coupling factor. This calculation allows for an improvement in sensitivity of around four orders of magnitude relative to other dark photon exclusions and may be attained using existing data. We present how one converts haloscope axion search limits and a summary of relevant experimental parameters from published searches. In addition, we have included the code that can be used to generate our dark photon exclusion limits for the cases described in this paper. Finally, we present limits on the kinetic mixing coefficient between dark photons and the Standard Model photons based on existing haloscope axion searches., Comment: 4 pages of content plus 2 pages of bibliography, 1 figure; updated with code for a statistical analysis on the polarization of the dark photon; accepted for publication in PRD

Published
2021

13. Imaging individual barium atoms in solid xenon for barium tagging in nEXO

Author

X. S. Jiang, A. Der Mesrobian-Kabakian, T. Tolba, S. Rescia, D. Fairbank, A. Piepke, Y. Y. Ding, O. Zeldovich, D. Kodroff, T. Daniels, J. Echevers, R. DeVoe, M. Hughes, Simon Johnston, R. Saldanha, O. Nusair, R. Krücken, Alexis G. Schubert, R. MacLellan, G. St-Hilaire, C. Chambers, I. J. Arnquist, Lorenzo Fabris, J.-L. Vuilleumier, N. Roy, Yuehe Lin, U. Wichoski, L. Cao, David Moore, B. T. Cleveland, John L. Orrell, S. Kravitz, F. Nolet, Veljko Radeka, Jens Dilling, B. Mong, M. Wagenpfeil, J. Dalmasson, T. Ziegler, J. P. Brodsky, T. Bhatta, P. C. Rowson, A.C. Odian, I. Badhrees, M. Heffner, Z. Li, Gerrit Wrede, D. Fudenberg, S. X. Wu, M. Tarka, F. Vachon, G. Li, Douglas H Beck, L. J. Wen, S. Parent, Samuele Sangiorgio, A. House, David Leonard, W. Cree, L. Darroch, J. Todd, G. Gallina, Y-R Yen, Thomas Koffas, W. M. Fairbank, I. Ostrovskiy, K. S. Kumar, D. A. Harris, X.L. Sun, J. B. Zhao, S. Delaquis, T. Stiegler, A. Kuchenkov, M. J. Dolinski, X. F. Wu, A. Larson, Yunyan Zhou, O. Njoya, E. V. Hansen, Giorgio Gratta, K. Skarpaas, Ethan Brown, A. Iverson, Triveni Rao, M. Weber, Shu Li, A. Karelin, P. Hufschmidt, David A. Sinclair, Wei Wu, R.J. Newby, T. Rossignol, M. J. Jewell, Qun-Yao Wang, Zhijun Ning, Y. Ito, L. J. Kaufman, Wei Wei, Rejean Fontaine, S. J. Daugherty, F. Bourque, Y. Lan, Liang Yang, R. Tsang, A. Jamil, S. Feyzbakhsh, C. Licciardi, W. R. Cen, R. Gornea, Guofu Cao, E. Raguzin, J. Farine, Eric W. Hoppe, Gerard Visser, A. Burenkov, T. Brunner, Arun Kumar Soma, Justin Albert, J. Watkins, V.N. Stekhanov, M. Coon, A. Pocar, Cory T. Overman, T. Tsang, A. Craycraft, Venkatesh Veeraraghavan, F. Retiere, Angelo Dragone, Jochen M. Schneider, Qing Xia, X. Zhang, M. Chiu, J. Hößl, P. S. Barbeau, G. S. Ortega, Jean-Francois Pratte, V. A. Belov, M. Oriunno, Serge A. Charlebois, T. I. Totev, K. Murray, Gisela Anton, T. Walton, J. Daughhetee, A. E. Robinson, K. Odgers, M. Côté, Thilo Michel, and Gabriele Giacomini

Subjects
Physics, Sapphire window, Multidisciplinary, 010308 nuclear & particles physics, Analytical chemistry, chemistry.chemical_element, Barium, 01 natural sciences, Particle identification, Background level, Xenon, chemistry, Double beta decay, 0103 physical sciences, Atom, Neutrino, 010306 general physics
Abstract

Author(s): Chambers, C; Walton, T; Fairbank, D; Craycraft, A; Yahne, DR; Todd, J; Iverson, A; Fairbank, W; Alamare, A; Albert, JB; Anton, G; Arnquist, IJ; Badhrees, I; Barbeau, PS; Beck, D; Belov, V; Bhatta, T; Bourque, F; Brodsky, JP; Brown, E; Brunner, T; Burenkov, A; Cao, GF; Cao, L; Cen, WR; Charlebois, SA; Chiu, M; Cleveland, B; Coon, M; Cree, W; Cote, M; Dalmasson, J; Daniels, T; Darroch, L; Daugherty, SJ; Daughhetee, J; Delaquis, S; Mesrobian-Kabakian, A Der; DeVoe, R; Dilling, J; Ding, YY; Dolinski, MJ; Dragone, A; Echevers, J; Fabris, L; Farine, J; Feyzbakhsh, S; Fontaine, R; Fudenberg, D; Giacomini, G; Gornea, R; Gratta, G; Hansen, EV; Heffner, M; Hoppe, EW; Hosl, J; House, A; Hufschmidt, P; Hughes, M; Ito, Y; Jamil, A; Jessiman, C; Jewell, MJ; Jiang, XS; Karelin, A; Kaufman, LJ; Kodroff, D; Koffas, T; Kravitz, S; Krucken, R; Kuchenkov, A; Kumar, KS; Lan, Y; Larson, A; Leonard, DS; Li, G; Li, S; Li, Z; Licciardi, C; Lin, YH; Lv, P; MacLellan, R; Michel, T; Mong, B; Moore, DC | Abstract: The search for neutrinoless double beta decay probes the fundamental properties of neutrinos, including whether or not the neutrino and antineutrino are distinct. Double beta detectors are large and expensive, so background reduction is essential for extracting the highest sensitivity. The identification, or 'tagging', of the $^{136}$Ba daughter atom from double beta decay of $^{136}$Xe provides a technique for eliminating backgrounds in the nEXO neutrinoless double beta decay experiment. The tagging scheme studied in this work utilizes a cryogenic probe to trap the barium atom in solid xenon, where the barium atom is tagged via fluorescence imaging in the solid xenon matrix. Here we demonstrate imaging and counting of individual atoms of barium in solid xenon by scanning a focused laser across a solid xenon matrix deposited on a sapphire window. When the laser sits on an individual atom, the fluorescence persists for $\sim$30~s before dropping abruptly to the background level, a clear confirmation of one-atom imaging. No barium fluorescence persists following evaporation of a barium deposit to a limit of $\leq$0.16\%. This is the first time that single atoms have been imaged in solid noble element. It establishes the basic principle of a barium tagging technique for nEXO.

Published
2019

14. Reflectivity of VUV-sensitive Silicon Photomultipliers in Liquid Xenon

Author

M. Heffner, Thilo Michel, M. Hughes, F. Vachon, Jean-Francois Pratte, Aleksey E. Bolotnikov, A. Craycraft, R. DeVoe, C. Gingras, C.R. Natzke, A. De St. Croix, T. I. Totev, K. Murray, Gisela Anton, J. C. Nzobadila Ondze, S. Al Kharusi, R. Saldanha, O. Nusair, J. Ringuette, R. Krücken, W. M. Fairbank, M. Worcester, A. Der Mesrobian-Kabakian, N. Massacret, Lorenzo Fabris, David Moore, Wen-Qi Yan, K. Harouaka, R. Gornea, E. Hansen, C. T. Overman, Samuele Sangiorgio, I. Ostrovskiy, H. Rasiwala, M. Tarka, K. S. Kumar, M. Elbeltagi, R. Tsang, A. Larson, John L. Orrell, T. Daniels, E. Caden, F. Retière, Z. Li, Mike Richman, N. Roy, S. Feyzbakhsh, G. Giacomini, M. Murra, G. Li, E. Raguzin, A. Pocar, A. Iverson, Ethan Brown, B. Mong, C. Licciardi, F. Nolet, J. P. Brodsky, A. Tidball, T. McElroy, Shu Li, T. Rossignol, V. A. Belov, R. MacLellan, O. Zeldovich, M. Medina Peregrina, A. Karelin, B. T. Cleveland, K. Odgers, I. Badhrees, Venkatesh Veeraraghavan, D. Fairbank, A. Kuchenkov, M. Wagenpfeil, M. Walent, Giorgio Gratta, Qing Xia, Sergio Ferrara, C. Vivo-Vilches, D. Schulte, Govinda Adhikari, G. S. Ortega, J. Todd, Arun Kumar Soma, C. Weinheimer, T. Brunner, D. S. Leonard, Serge A. Charlebois, A. Odian, L. Darroch, S. Rescia, C. Huhmann, M. J. Dolinski, M. J. Jewell, R. Lindsay, D. Chernyak, L. Althueser, V.N. Stekhanov, M. L. Di Vacri, T. Ziegler, Y. Lan, S. Parent, L. J. Kaufman, A. Gorham, S. X. Wu, P. A. Breur, J. Bane, A. E. Robinson, Eric W. Hoppe, J. Echevers, D. Goeldi, G.J. Ramonnye, Liang Yang, A. Jamil, S. Thibado, C. Richard, M. Chiu, J. Farine, P. Martel-Dion, Guofu Cao, T. Bhatta, J. Nattress, E. Angelico, B. Chana, Douglas H Beck, T. Stiegler, J. Schneider, K. Deslandes, P. C. Rowson, A. House, A. Fieguth, C.A. Hardy, U. Wichoski, S. Viel, G. Gallina, A. Piepke, I. J. Arnquist, P. Gautam, K. G. Leach, R.J. Newby, S. Triambak, F. Spadoni, and C. Chambers

Subjects
Materials science, Physics - Instrumentation and Detectors, APDS, chemistry.chemical_element, FOS: Physical sciences, 01 natural sciences, 7. Clean energy, 030218 nuclear medicine & medical imaging, law.invention, 03 medical and health sciences, 0302 clinical medicine, Optics, Silicon photomultiplier, Xenon, law, 0103 physical sciences, Wafer, Angular resolution, Instrumentation, Mathematical Physics, 010308 nuclear & particles physics, business.industry, Detector, Instrumentation and Detectors (physics.ins-det), Avalanche photodiode, chemistry, Angle of incidence (optics), business
Abstract

Silicon photomultipliers are regarded as a very promising technology for next-generation, cutting-edge detectors for low-background experiments in particle physics. This work presents systematic reflectivity studies of Silicon Photomultipliers (SiPM) and other samples in liquid xenon at vacuum ultraviolet (VUV) wavelengths. A dedicated setup at the University of M\"unster has been used that allows to acquire angle-resolved reflection measurements of various samples immersed in liquid xenon with 0.45{\deg} angular resolution. Four samples are investigated in this work: one Hamamatsu VUV4 SiPM, one FBK VUV-HD SiPM, one FBK wafer sample and one Large-Area Avalanche Photodiode (LA-APD) from EXO-200. The reflectivity is determined to be 25-36% at an angle of incidence of 20{\deg} for the four samples and increases to up to 65% at 70{\deg} for the LA-APD and the FBK samples. The Hamamatsu VUV4 SiPM shows a decline with increasing angle of incidence. The reflectivity results will be incorporated in upcoming light response simulations of the nEXO detector., Comment: 18 pages, 11 figures

Published
2021

15. Joint Analysis of BICEP2/Keck ArrayandPlanckData

Author

P. A. R. Ade, N. Aghanim, Z. Ahmed, R. W. Aikin, K. D. Alexander, M. Arnaud, J. Aumont, C. Baccigalupi, A. J. Banday, D. Barkats, R. B. Barreiro, J. G. Bartlett, N. Bartolo, E. Battaner, K. Benabed, A. Benoît, A. Benoit-Lévy, S. J. Benton, J.-P. Bernard, M. Bersanelli, P. Bielewicz, C. A. Bischoff, J. J. Bock, A. Bonaldi, L. Bonavera, J. R. Bond, J. Borrill, F. R. Bouchet, F. Boulanger, J. A. Brevik, M. Bucher, I. Buder, E. Bullock, C. Burigana, R. C. Butler, V. Buza, E. Calabrese, J.-F. Cardoso, A. Catalano, A. Challinor, R.-R. Chary, H. C. Chiang, P. R. Christensen, L. P. L. Colombo, C. Combet, J. Connors, F. Couchot, A. Coulais, B. P. Crill, A. Curto, F. Cuttaia, L. Danese, R. D. Davies, R. J. Davis, P. de Bernardis, A. de Rosa, G. de Zotti, J. Delabrouille, J.-M. Delouis, F.-X. Désert, C. Dickinson, J. M. Diego, H. Dole, S. Donzelli, O. Doré, M. Douspis, C. D. Dowell, L. Duband, A. Ducout, J. Dunkley, X. Dupac, C. Dvorkin, G. Efstathiou, F. Elsner, T. A. Enßlin, H. K. Eriksen, E. Falgarone, J. P. Filippini, F. Finelli, S. Fliescher, O. Forni, M. Frailis, A. A. Fraisse, E. Franceschi, A. Frejsel, S. Galeotta, S. Galli, K. Ganga, T. Ghosh, M. Giard, E. Gjerløw, S. R. Golwala, J. González-Nuevo, K. M. Górski, S. Gratton, A. Gregorio, A. Gruppuso, J. E. Gudmundsson, M. Halpern, F. K. Hansen, D. Hanson, D. L. Harrison, M. Hasselfield, G. Helou, S. Henrot-Versillé, D. Herranz, S. R. Hildebrandt, G. C. Hilton, E. Hivon, M. Hobson, W. A. Holmes, W. Hovest, V. V. Hristov, K. M. Huffenberger, H. Hui, G. Hurier, K. D. Irwin, A. H. Jaffe, T. R. Jaffe, J. Jewell, W. C. Jones, M. Juvela, A. Karakci, K. S. Karkare, J. P. Kaufman, B. G. Keating, S. Kefeli, E. Keihänen, S. A. Kernasovskiy, R. Keskitalo, T. S. Kisner, R. Kneissl, J. Knoche, L. Knox, J. M. Kovac, N. Krachmalnicoff, M. Kunz, C. L. Kuo, H. Kurki-Suonio, G. Lagache, A. Lähteenmäki, J.-M. Lamarre, A. Lasenby, M. Lattanzi, C. R. Lawrence, E. M. Leitch, R. Leonardi, F. Levrier, A. Lewis, M. Liguori, P. B. Lilje, M. Linden-Vørnle, M. López-Caniego, P. M. Lubin, M. Lueker, J. F. Macías-Pérez, B. Maffei, D. Maino, N. Mandolesi, A. Mangilli, M. Maris, P. G. Martin, E. Martínez-González, S. Masi, P. Mason, S. Matarrese, K. G. Megerian, P. R. Meinhold, A. Melchiorri, L. Mendes, A. Mennella, M. Migliaccio, S. Mitra, M.-A. Miville-Deschênes, A. Moneti, L. Montier, G. Morgante, D. Mortlock, A. Moss, D. Munshi, J. A. Murphy, P. Naselsky, F. Nati, P. Natoli, C. B. Netterfield, H. T. Nguyen, H. U. Nørgaard-Nielsen, F. Noviello, D. Novikov, I. Novikov, R. O’Brient, R. W. Ogburn, A. Orlando, L. Pagano, F. Pajot, R. Paladini, D. Paoletti, B. Partridge, F. Pasian, G. Patanchon, T. J. Pearson, O. Perdereau, L. Perotto, V. Pettorino, F. Piacentini, M. Piat, D. Pietrobon, S. Plaszczynski, E. Pointecouteau, G. Polenta, N. Ponthieu, G. W. Pratt, S. Prunet, C. Pryke, J.-L. Puget, J. P. Rachen, W. T. Reach, R. Rebolo, M. Reinecke, M. Remazeilles, C. Renault, A. Renzi, S. Richter, I. Ristorcelli, G. Rocha, M. Rossetti, G. Roudier, M. Rowan-Robinson, J. A. Rubiño-Martín, B. Rusholme, M. Sandri, D. Santos, M. Savelainen, G. Savini, R. Schwarz, D. Scott, M. D. Seiffert, C. D. Sheehy, L. D. Spencer, Z. K. Staniszewski, V. Stolyarov, R. Sudiwala, R. Sunyaev, D. Sutton, A.-S. Suur-Uski, J.-F. Sygnet, J. A. Tauber, G. P. Teply, L. Terenzi, K. L. Thompson, L. Toffolatti, J. E. Tolan, M. Tomasi, M. Tristram, M. Tucci, A. D. Turner, L. Valenziano, J. Valiviita, B. Van Tent, L. Vibert, P. Vielva, A. G. Vieregg, F. Villa, L. A. Wade, B. D. Wandelt, R. Watson, A. C. Weber, I. K. Wehus, M. White, S. D. M. White, J. Willmert, C. L. Wong, K. W. Yoon, D. Yvon, A. Zacchei, and A. Zonca

Published
2015
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16. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Author

D. KLIONSKY, A. ABDEL-AZIZ, S. ABDELFATAH, M. ABDELLATIF, A. ABDOLI, S. ABEL, H. ABELIOVICH, M. ABILDGAARD, Y. ABUDU, A. ACEVEDO-AROZENA, I. ADAMOPOULOS, K. ADELI, T. ADOLPH, A. ADORNETTO, E. AFLAKI, G. AGAM, A. AGARWAL, B. AGGARWAL, M. AGNELLO, P. AGOSTINIS, J. AGREWALA, A. AGROTIS, P. AGUILAR, S. AHMAD, Z. AHMED, U. AHUMADA-CASTRO, S. AITS, S. AIZAWA, Y. AKKOC, T. AKOUMIANAKI, H. AKPINAR, A. AL-ABD, L. AL-AKRA, A. AL-GHARAIBEH, M. ALAOUI-JAMALI, S. ALBERTI, E. ALCOCER-GOMEZ, C. ALESSANDRI, M. ALI, M. AL-BARI, S. ALIWAINI, J. ALIZADEH, E. ALMACELLAS, A. ALMASAN, A. ALONSO, G. ALONSO, N. ALTAN-BONNET, D. ALTIERI, S. ALVES, C. DA COSTA, M. ALZAHARNA, M. AMADIO, C. AMANTINI, C. AMARAL, S. AMBROSIO, A. AMER, V. AMMANATHAN, Z. AN, S. ANDERSEN, S. ANDRABI, M. ANDRADE-SILVA, A. ANDRES, S. ANGELINI, D. ANN, U. ANOZIE, M. ANSARI, P. ANTAS, A. ANTEBI, Z. ANTON, T. ANWAR, L. APETOH, N. APOSTOLOVA, T. ARAKI, Y. ARAKI, K. ARASAKI, W. ARAUJO, J. ARAYA, C. ARDEN, M. AREVALO, S. ARGUELLES, E. ARIAS, J. ARIKKATH, H. ARIMOTO, A. ARIOSA, D. ARMSTRONG-JAMES, L. ARNAUNE-PELLOQUIN, A. AROCA, D. ARROYO, I. ARSOV, R. ARTERO, D. ASARO, M. ASCHNER, M. ASHRAFIZADEH, O. ASHUR-FABIAN, A. ATANASOV, A. AU, P. AUBERGER, H. AUNER, L. AURELIAN, R. AUTELLI, L. AVAGLIANO, Y. AVALOS, S. AVEIC, C. AVELEIRA, T. AVINWITTENBERG, Y. AYDIN, S. AYTON, S. AYYADEVARA, M. AZZOPARDI, M. BABA, J. BACKER, S. BACKUES, D. BAE, O. BAE, S. BAE, E. BAEHRECKE, A. BAEK, S. BAEK, G. BAGETTA, A. BAGNIEWSKA-ZADWORNA, H. BAI, J. BAI, X. BAI, Y. BAI, N. BAIRAGI, S. BAKSI, T. BALBI, C. BALDARI, W. BALDUINI, A. BALLABIO, M. BALLESTER, S. BALAZADEH, R. BALZAN, R. BANDOPADHYAY, S. BANERJEE, Y. BAO, M. BAPTISTA, A. BARACCA, C. BARBATI, A. BARGIELA, D. BARILA, P. BARLOW, S. BARMADA, E. BARREIRO, G. BARRETO, J. BARTEK, B. BARTEL, A. BARTOLOME, G. BARVE, S. BASAGOUDANAVAR, D. BASSHAM, R. JR, A. BASU, H. BATOKO, I. BATTEN, E. BAULIEU, B. BAUMGARNER, J. BAYRY, R. BEALE, I. BEAU, F. BEAUMATIN, L. BECHARA, G. BECK, M. BEERS, J. BEGUN, C. BEHRENDS, G. BEHRENS, R. BEI, E. BEJARANO, S. BEL, C. BEHL, A. BELAID, N. BELGAREH-TOUZE, C. BELLAROSA, F. BELLEUDI, M. PEREZ, R. BELLO-MORALES, J. BELTRAN, S. BELTRAN, D. BENBROOK, M. BENDORIUS, B. BENITEZ, I. BENITO-CUESTA, J. BENSALEM, M. BERCHTOLD, S. BEREZOWSKA, D. BERGAMASCHI, M. BERGAMI, A. BERGMANN, L. BERLIOCCHI, C. BERLIOZ-TORRENT, A. BERNARD, L. BERTHOUX, C. BESIRLI, S. BESTEIRO, V. BETIN, R. BEYAERT, J. BEZBRADICA, K. BHASKAR, I. BHATIA-KISSOVA, R. BHATTACHARYA, S. BHATTACHARYA, S. BHATTACHARYYA, M. BHUIYAN, S. BHUTIA, L. BI, X. BI, T. BIDEN, K. BIJIAN, V. BILLES, N. BINART, C. BINCOLETTO, A. BIRGISDOTTIR, G. BJORKOY, G. BLANCO, A. BLAS-GARCIA, J. BLASIAK, R. BLOMGRAN, K. BLOMGREN, J. BLUM, E. BOADA-ROMERO, M. BOBAN, K. BOESZEBATTAGLIA, P. BOEUF, B. BOLAND, P. BOMONT, P. BONALDO, S. BONAM, L. BONFILI, J. BONIFACINO, B. BOONE, M. BOOTMAN, M. BORDI, C. BORNER, B. BORNHAUSER, G. BORTHAKUR, J. BOSCH, S. BOSE, L. BOTANA, J. BOTAS, C. BOULANGER, M. BOULTON, M. BOURDENX, B. BOURGEOIS, N. BOURKE, G. BOUSQUET, P. BOYA, P. BOZHKOV, L. BOZI, T. BOZKURT, D. BRACKNEY, C. BRANDTS, R. BRAUN, G. BRAUS, R. BRAVO-SAGUA, J. BRAVO-SAN PEDRO, P. BREST, M. BRINGER, A. BRIONES-HERRERA, V. BROADDUS, P. BRODERSEN, E. ALVAREZ, J. BRODSKY, S. BRODY, P. BRONSON, J. BRONSTEIN, C. BROWN, R. BROWN, P. BRUM, J. BRUMELL, N. BRUNETTI-PIERRI, D. BRUNO, R. BRYSON-RICHARDSON, C. BUCCI, C. BUCHRIESER, M. BUENO, L. BUITRAGO-MOLINA, S. BURASCHI, S. BUCH, J. BUCHAN, E. BUCKINGHAM, H. BUDAK, M. BUDINI, G. BULTYNCK, F. BURADA, J. BURGOYNE, M. BURON, V. BUSTOS, S. BUTTNER, E. BUTTURINI, A. BYRD, I. CABAS, S. CABRERA-BENITEZ, K. CADWELL, J. CAI, L. CAI, Q. CAI, M. CAIRO, J. CALBET, G. CALDWELL, K. CALDWELL, J. CALL, R. CALVANI, A. CALVO, M. BARRERA, N. CAMARA, J. CAMONIS, N. CAMOUGRAND, M. CAMPANELLA, E. CAMPBELL, F. CAMPBELL-VALOIS, S. CAMPELLO, I. CAMPESI, J. CAMPOS, O. CAMUZARD, J. CANCINO, D. DE ALMEIDA, L. CANESI, I. CANIGGIA, B. CANONICO, C. CANTI, B. CAO, M. CARAGLIA, B. CARAMES, E. CARCHMAN, E. CARDENAL-MUNOZ, C. CARDENAS, L. CARDENAS, S. CARDOSO, J. CAREW, G. CARLE, G. CARLETON, S. CARLONI, D. CARMONA-GUTIERREZ, L. CARNEIRO, O. CARNEVALI, J. CAROSI, S. CARRA, A. CARRIER, L. CARRIER, B. CARROLL, A. CARTER, A. CARVALHO, M. CASANOVA, C. CASAS, J. CASAS, C. CASSIOLI, E. CASTILLO, K. CASTILLO, S. CASTILLO-LLUVA, F. CASTOLDI, M. CASTORI, A. CASTRO, M. CASTRO-CALDAS, J. CASTRO-HERNANDEZ, S. CASTRO-OBREGON, S. CATZ, C. CAVADAS, F. CAVALIERE, G. CAVALLINI, M. CAVINATO, M. CAYUELA, P. RICA, V. CECARINI, F. CECCONI, M. CECHOWSKA-PASKO, S. CENCI, V. CEPERUELO-MALLAFRE, J. CERQUEIRA, J. CERUTTI, D. CERVIA, V. CETINTAS, S. CETRULLO, H. CHAE, A. CHAGIN, C. CHAI, G. CHAKRABARTI, O. CHAKRABARTI, T. CHAKRABORTY, M. CHAMI, G. CHAMILOS, D. CHAN, E. CHAN, H. CHAN, M. CHAN, Y. CHAN, P. CHANDRA, C. CHANG, H. CHANG, K. CHANG, J. CHAO, T. CHAPMAN, N. CHARLET-BERGUERAND, S. CHATTERJEE, S. CHAUBE, A. CHAUDHARY, S. CHAUHAN, E. CHAUM, F. CHECLER, M. CHEETHAM, C. CHEN, G. CHEN, J. CHEN, L. CHEN, M. CHEN, N. CHEN, Q. CHEN, R. CHEN, S. CHEN, W. CHEN, X. CHEN, Y. CHEN, Z. CHEN, H. CHENG, J. CHENG, S. CHENG, W. CHENG, X. CHENG, Y. CHENG, Z. CHENG, H. CHEONG, J. CHEONG, B. CHERNYAK, S. CHERRY, C. CHEUNG, K. CHEUNG, E. CHEVET, R. CHI, A. CHIANG, F. CHIARADONNA, R. CHIARELLI, M. CHIARIELLO, N. CHICA, S. CHIOCCA, M. CHIONG, S. CHIOU, A. CHIRAMEL, V. CHIURCHIU, D. CHO, S. CHOE, A. CHOI, M. CHOI, K. CHOUDHURY, N. CHOW, C. CHU, J. CHUA, H. CHUNG, K. CHUNG, S. CHUNG, Y. CHUNG, V. CIANFANELLI, I. CIECHOMSKA, M. CIFUENTES, L. CINQUE, S. CIRAK, M. CIRONE, M. CLAGUE, R. CLARKE, E. CLEMENTI, E. COCCIA, P. CODOGNO, E. COHEN, M. COHEN, T. COLASANTI, F. COLASUONNO, R. COLBERT, A. COLELL, N. COLL, M. COLLINS, M. COLOMBO, D. COLON-RAMOS, L. COMBARET, S. COMINCINI, M. COMINETTI, A. CONSIGLIO, A. CONTE, F. CONTI, V. CONTU, M. COOKSON, K. COOMBS, I. COPPENS, M. CORASANITI, D. CORKERY, N. CORDES, K. CORTESE, M. COSTA, S. COSTANTINO, P. COSTELLI, A. COTO-MONTES, P. CRACK, J. CRESPO, A. CRIOLLO, V. CRIPPA, R. CRISTOFANI, T. CSIZMADIA, A. CUADRADO, B. CUI, J. CUI, Y. CUI, E. CULETTO, A. CUMINO, A. CYBULSKY, M. CZAJA, S. CZUCZWAR, S. D'ADAMO, M. D'AMELIO, D. D'ARCANGELO, A. D'LUGOS, G. D'ORAZI, J. DA SILVA, H. DAFSARI, R. DAGDA, Y. DAGDAS, M. DAGLIA, X. DAI, Y. DAI, J. DAL COL, P. DALHAIMER, L. DALLA VALLE, T. DALLENGA, G. DALMASSO, M. DAMME, I. DANDO, N. DANTUMA, A. DARLING, H. DAS, S. DASARATHY, S. DASARI, S. DASH, O. DAUMKE, A. DAUPHINEE, J. DAVIES, V. DAVILA, R. DAVIS, T. DAVIS, S. NAIDU, F. DE AMICIS, K. DE BOSSCHER, F. DE FELICE, L. DE FRANCESCHI, C. DE LEONIBUS, M. BARBOSA, G. DE MEYER, A. DE MILITO, C. DE NUNZIO, C. DE PALMA, M. DE SANTI, C. DE VIRGILIO, D. DE ZIO, J. DEBNATH, B. DEBOSCH, J. DECUYPERE, M. DEEHAN, G. DEFLORIAN, J. DEGREGORI, B. DEHAY, G. DEL RIO, J. DELANEY, L. DELBRIDGE, E. DELORME-AXFORD, M. DELPINO, F. DEMARCHI, V. DEMBITZ, N. DEMERS, H. DENG, Z. DENG, J. DENGJEL, P. DENT, D. DENTON, M. DEPAMPHILIS, C. DER, V. DERETIC, A. DESCOTEAUX, L. DEVIS, S. DEVKOTA, O. DEVUYST, G. DEWSON, M. DHARMASIVAM, R. DHIMAN, D. DI BERNARDO, M. DI CRISTINA, F. DI DOMENICO, P. DI FAZIO, A. DI FONZO, G. DI GUARDO, G. DI GUGLIELMO, L. DI LEO, C. DI MALTA, A. DI NARDO, M. DI RIENZO, F. DI SANO, G. DIALLINAS, J. DIAO, G. DIAZ-ARAYA, I. DIAZ-LAVIADA, J. DICKINSON, M. DIEDERICH, M. DIEUDE, I. DIKIC, S. DING, W. DING, L. DINI, M. DINIC, A. DINKOVA-KOSTOVA, M. DIONNE, J. DISTLER, A. DIWAN, I. DIXON, M. DJAVAHERI-MERGNY, I. DOBRINSKI, O. DOBROVINSKAYA, R. DOBROWOLSKI, R. DOBSON, S. EMRE, M. DONADELLI, B. DONG, X. DONG, Z. DONG, G. II, V. DOTSCH, H. DOU, J. DOU, M. DOWAIDAR, S. DRIDI, L. DRUCKER, A. DU, C. DU, G. DU, H. DU, L. DU, A. DU TOIT, S. DUAN, X. DUAN, S. DUARTE, A. DUBROVSKA, E. DUNLOP, N. DUPONT, R. DURAN, B. DWARAKANATH, S. DYSHLOVOY, D. EBRAHIMI-FAKHARI, L. ECKHART, C. EDELSTEIN, T. EFFERTH, E. EFTEKHARPOUR, L. EICHINGER, N. EID, T. EISENBERG, N. EISSA, S. EISSA, M. EJARQUE, A. EL ANDALOUSSI, N. EL-HAGE, S. EL-NAGGAR, A. ELEUTERI, E. EL-SHAFEY, M. ELGENDY, A. ELIOPOULOS, M. ELIZALDE, P. ELKS, H. ELSASSER, E. ELSHERBINY, B. EMERLING, N. EMRE, C. ENG, N. ENGEDAL, A. ENGELBRECHT, A. ENGELSEN, J. ENSERINK, R. ESCALANTE, A. ESCLATINE, M. ESCOBAR-HENRIQUES, E. ESKELINEN, L. ESPERT, M. EUSEBIO, G. FABRIAS, C. FABRIZI, A. FACCHIANO, F. FACCHIANO, B. FADEEL, C. FADER, A. FAESEN, W. FAIRLIE, A. FALCO, B. FALKENBURGER, D. FAN, J. FAN, Y. FAN, E. FANG, Y. FANG, M. FANTO, T. FARFEL-BECKER, M. FAURE, G. FAZELI, A. FEDELE, A. FELDMAN, D. FENG, J. FENG, L. FENG, Y. FENG, W. FENG, T. ARAUJO, T. FERGUSON, J. FERNANDEZ-CHECA, S. FERNANDEZVELEDO, A. FERNIE, A. FERRANTE, A. FERRARESI, M. FERRARI, J. FERREIRA, S. FERRO-NOVICK, A. FIGUERAS, R. FILADI, N. FILIGHEDDU, E. FILIPPICHIELA, G. FILOMENI, G. FIMIA, V. FINESCHI, F. FINETTI, S. FINKBEINER, E. FISHER, P. FISHER, F. FLAMIGNI, S. FLIESLER, T. FLO, I. FLORANCE, O. FLOREY, T. FLORIO, E. FODOR, C. FOLLO, E. FON, A. FORLINO, F. FORNAI, P. FORTINI, A. FRACASSI, A. FRALDI, B. 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SAFTIG, A. SAGONA, G. SAHAY, A. SAHEBKAR, M. SAHIN, O. SAHIN, S. SAHNI, N. SAITO, S. SAITO, T. SAITO, R. SAKAI, Y. SAKAI, J. SAKAMAKI, K. SAKSELA, G. SALAZAR, A. SALAZAR-DEGRACIA, G. SALEKDEH, A. SALUJA, B. SAMPAIO-MARQUES, M. SANCHEZ, J. SANCHEZ-ALCAZAR, V. SANCHEZ-VERA, V. SANCHO-SHIMIZU, J. SANDERSON, M. SANDRI, S. SANTAGUIDA, L. SANTAMBROGIO, M. SANTANA, G. SANTONI, A. SANZ, P. SANZ, S. SARAN, M. SARDIELLO, T. SARGEANT, A. SARIN, C. SARKAR, S. SARKAR, M. SARRIAS, D. SARMAH, J. SARPARANTA, A. SATHYANARAYAN, R. SATHYANARAYANAN, K. SCAGLIONE, F. SCATOZZA, L. SCHAEFER, Z. SCHAFER, U. SCHAIBLE, A. SCHAPIRA, M. SCHARL, H. SCHATZL, C. SCHEIN, W. SCHEPER, D. SCHEURING, M. SCHIAFFINO, M. SCHIAPPACASSI, R. SCHINDL, U. SCHLATTNER, O. SCHMIDT, R. SCHMITT, S. SCHMIDT, I. SCHMITZ, E. SCHMUKLER, A. SCHNEIDER, B. SCHNEIDER, R. SCHOBER, A. SCHOIJET, M. SCHOTT, M. SCHRAMM, B. SCHRODER, K. SCHUH, C. SCHULLER, R. SCHULZE, L. SCHURMANNS, J. SCHWAMBORN, M. SCHWARTEN, F. SCIALO, S. SCIARRETTA, M. SCOTT, K. SCOTTO, A. SCOVASSI, A. SCRIMA, A. SCRIVO, D. SEBASTIAN, S. SEBTI, S. SEDEJ, L. SEGATORI, N. SEGEV, P. SEGLEN, I. SEILIEZ, E. SEKI, S. SELLECK, F. SELLKE, A. PEREZ-LARA, J. SELSBY, M. SENDTNER, S. SENTURK, E. SERANOVA, C. SERGI, R. SERRA-MORENO, H. SESAKI, C. SETTEMBRE, S. SETTY, G. SGARBI, O. SHA, J. SHACKA, J. SHAH, D. SHANG, C. SHAO, F. SHAO, S. SHARBATI, L. SHARKEY, D. SHARMA, G. SHARMA, K. SHARMA, P. SHARMA, S. SHARMA, H. SHEN, J. SHEN, M. SHEN, W. SHEN, Z. SHEN, R. SHENG, Z. SHENG, J. SHI, X. SHI, Y. SHI, K. SHIBA-FUKUSHIMA, J. SHIEH, Y. SHIMADA, S. SHIMIZU, M. SHIMOZAWA, T. SHINTANI, C. SHOEMAKER, S. SHOJAEI, I. SHOJI, B. SHRAVAGE, V. SHRIDHAR, C. SHU, H. SHU, K. SHUI, A. SHUKLA, T. SHUTT, V. SICA, A. SIDDIQUI, A. SIERRA, V. SIERRA-TORRE, S. SIGNORELLI, P. SIL, B. SILVA, J. SILVA, E. SILVA-PAVEZ, S. SILVENTE-POIROT, R. SIMMONDS, A. SIMON, H. SIMON, M. SIMONS, A. SINGH, L. SINGH, R. SINGH, S. SINGH, D. SINHA, R. SINHA, S. SINHA, A. SIRKO, K. SIROHI, E. SIVRIDIS, P. SKENDROS, A. SKIRYCZ, I. SLANINOVA, S. SMAILI, A. SMERTENKO, M. SMITH, S. SOENEN, E. SOHN, S. SOK, G. SOLAINI, T. SOLDATI, S. SOLEIMANPOUR, R. SOLER, A. SOLOVCHENKO, J. SOMARELLI, A. SONAWANE, F. SONG, H. SONG, J. SONG, K. SONG, Z. SONG, L. SORIA, M. SORICE, A. SOUKAS, S. SOUKUP, D. SOUSA, N. SOUSA, P. SPAGNUOLO, S. SPECTOR, M. BHARATH, D. ST CLAIR, V. STAGNI, L. STAIANO, C. STALNECKER, M. STANKOV, P. STATHOPULOS, K. STEFAN, S. STEFAN, L. STEFANIS, J. STEFFAN, A. STEINKASSERER, H. STENMARK, J. STERNECKERT, C. STEVENS, V. STOKA, S. STORCH, B. STORK, F. STRAPPAZZON, A. STROHECKER, D. STUPACK, H. SU, L. SU, A. SUAREZFONTES, C. SUBAUSTE, S. SUBBIAN, P. SUBIRADA, G. SUDHANDIRAN, C. SUE, X. SUI, C. SUMMERS, G. SUN, J. SUN, K. SUN, M. SUN, Q. SUN, Y. SUN, Z. SUN, K. SUNAHARA, E. SUNDBERG, K. SUSZTAK, P. SUTOVSKY, H. SUZUKI, G. SWEENEY, J. SYMONS, S. SZE, N. SZEWCZYK, C. TABOLACCI, F. TACKE, H. TAEGTMEYER, M. TAFANI, M. TAGAYA, H. TAI, S. TAIT, Y. TAKAHASHI, S. TAKATS, P. TALWAR, C. TAM, S. TAM, D. TAMPELLINI, A. TAMURA, C. TAN, E. TAN, Y. TAN, M. TANAKA, D. TANG, J. TANG, T. TANG, I. TANIDA, Z. TAO, M. TAOUIS, L. TATENHORST, N. TAVERNARAKIS, A. TAYLOR, G. TAYLOR, J. TAYLOR, E. TCHETINA, A. TEE, I. TEGEDER, D. TEIS, N. TEIXEIRA, F. TEIXEIRA-CLERC, K. TEKIRDAG, T. TENCOMNAO, S. TENREIRO, A. TEPIKIN, P. TESTILLANO, G. TETTAMANTI, P. THARAUX, K. THEDIECK, A. THEKKINGHAT, S. THELLUNG, J. THINWA, V. THIRUMALAIKUMAR, S. THOMAS, P. THOMES, A. THORBURN, L. THUKRAL, T. THUM, M. THUMM, L. TIAN, A. TICHY, A. TILL, V. TIMMERMAN, V. TITORENKO, S. TODI, K. TODOROVA, J. TOIVONEN, L. TOMAIPITINCA, D. TOMAR, C. TOMAS-ZAPICO, B. TONG, C. TONG, X. TONG, S. TOOZE, M. TORGERSEN, S. TORII, L. TORRES-LOPEZ, A. TORRIGLIA, C. TOWERS, R. TOWNS, S. TOYOKUNI, V. TRAJKOVIC, D. TRAMONTANO, Q. TRAN, L. TRAVASSOS, C. TRELFORD, S. TREMEL, I. TROUGAKOS, B. TSAO, M. TSCHAN, H. TSE, T. TSE, H. TSUGAWA, A. TSVETKOV, D. TUMBARELLO, Y. TUMTAS, M. TUNON, S. TURCOTTE, B. TURK, V. TURK, B. TURNER, R. TUXWORTH, J. TYLER, E. TYUTEREVA, Y. UCHIYAMA, A. UGUNKLUSEK, H. UHLIG, I. ULASOV, M. UMEKAWA, C. UNGERMANN, R. UNNO, S. URBE, E. URIBE-CARRETERO, S. USTUN, V. UVERSKY, T. VACCARI, M. VACCARO, B. VAHSEN, H. VAKIFAHMETOGLU-NORBERG, R. VALDOR, M. VALENTE, A. VALKO, R. VALLEE, A. VALVERDE, G. VAN DEN BERGHE, S. VAN DER VEEN, L. VAN KAER, J. VAN LOOSDREGT, S. VAN WIJK, W. VANDENBERGHE, I. VANHOREBEEK, M. VANNIER-SANTOS, N. VANNINI, M. VANRELL, C. VANTAGGIATO, G. VARANO, I. VARELA-NIETO, M. VARGA, M. VASCONCELOS, S. VATS, D. VAVVAS, I. VEGANAREDO, S. VEGA-RUBIN-DE-CELIS, G. VELASCO, A. VELAZQUEZ, T. VELLAI, E. VELLENGA, F. VELOTTI, M. VERDIER, P. VERGINIS, I. VERGNE, P. VERKADE, M. VERMA, P. VERSTREKEN, T. VERVLIET, J. VERVOORTS, A. VESSONI, V. VICTOR, M. VIDAL, C. VIDONI, O. VIEIRA, R. VIERSTRA, S. VIGANO, H. VIHINEN, V. VIJAYAN, M. VILA, M. VILAR, J. VILLALBA, A. VILLALOBO, B. VILLAREJO-ZORI, F. VILLARROYA, J. VILLARROYA, O. VINCENT, C. VINDIS, C. VIRET, M. VISCOMI, D. VISNJIC, I. VITALE, D. VOCADLO, O. VOITSEKHOVSKAJA, C. VOLONTE, M. VOLTA, M. VOMERO, C. VON HAEFEN, M. VOOIJS, W. VOOS, L. VUCICEVIC, R. WADE-MARTINS, S. WAGURI, K. WAITE, S. WAKATSUKI, D. WALKER, M. WALKER, S. WALKER, J. WALTER, F. WANDOSELL, B. WANG, C. WANG, D. WANG, F. WANG, G. WANG, H. WANG, J. WANG, K. WANG, L. WANG, M. WANG, N. WANG, P. WANG, Q. WANG, W. WANG, X. WANG, Y. WANG, Z. WANG, G. WARNES, V. WARNSMANN, H. WATADA, E. WATANABE, M. WATCHON, T. WEAVER, G. WEGRZYN, A. WEHMAN, H. WEI, L. WEI, T. WEI, Y. WEI, O. WEIERGRABER, C. WEIHL, G. WEINDL, R. WEISKIRCHEN, A. WELLS, R. WEN, X. WEN, A. WERNER, B. WEYKOPF, S. WHEATLEY, J. WHITTON, A. WHITWORTH, K. WIKTORSKA, M. WILDENBERG, T. WILEMAN, S. WILKINSON, D. WILLBOLD, B. WILLIAMS, R. WILLIAMS, P. WILLIAMSON, R. WILSON, B. WINNER, N. WINSOR, S. WITKIN, H. WODRICH, U. WOEHLBIER, T. WOLLERT, E. WONG, J. WONG, R. WONG, V. WONG, W. WONG, A. WU, C. WU, J. WU, K. WU, M. WU, S. WU, W. WU, X. WU, Y. WU, R. XAVIER, H. XIA, L. XIA, Z. XIA, G. XIANG, J. XIANG, M. XIANG, W. XIANG, B. XIAO, G. XIAO, H. XIAO, J. XIAO, L. XIAO, S. XIAO, Y. XIAO, B. XIE, C. XIE, M. XIE, Y. XIE, Z. XIE, M. XILOURI, C. XU, E. XU, H. XU, J. XU, L. XU, W. XU, X. XU, Y. XUE, S. YAKHINE-DIOP, M. YAMAGUCHI, O. YAMAGUCHI, A. YAMAMOTO, S. YAMASHINA, S. YAN, Z. YAN, Y. YANAGI, C. YANG, D. YANG, H. YANG, J. YANG, L. YANG, M. YANG, P. YANG, Q. YANG, S. YANG, W. YANG, X. YANG, Y. YANG, H. YAO, S. YAO, X. YAO, Y. YAO, T. YASUI, M. YAZDANKHAH, P. YEN, C. YI, X. YIN, Y. YIN, Z. YIN, M. YING, Z. YING, C. YIP, S. YIU, Y. YOO, K. YOSHIDA, S. YOSHII, T. YOSHIMORI, B. YOUSEFI, B. YU, H. YU, J. YU, L. YU, M. YU, S. YU, V. YU, W. YU, Z. YU, J. YUAN, L. YUAN, S. YUAN, Y. YUAN, Z. YUAN, J. YUE, Z. YUE, J. YUN, R. YUNG, D. ZACKS, G. ZAFFAGNINI, V. ZAMBELLI, I. ZANELLA, Q. ZANG, S. ZANIVAN, S. ZAPPAVIGNA, P. ZARAGOZA, K. ZARBALIS, A. ZAREBKOHAN, A. ZARROUK, S. ZEITLIN, J. ZENG, E. ZEROVNIK, L. ZHAN, B. ZHANG, D. ZHANG, H. ZHANG, J. ZHANG, K. ZHANG, L. ZHANG, M. ZHANG, P. ZHANG, S. ZHANG, W. ZHANG, X. ZHANG, Y. ZHANG, Z. ZHANG, H. ZHAO, L. ZHAO, S. ZHAO, T. ZHAO, X. ZHAO, Y. ZHAO, G. ZHENG, K. ZHENG, L. ZHENG, S. ZHENG, X. ZHENG, Y. ZHENG, Z. ZHENG, B. ZHIVOTOVSKY, Q. ZHONG, A. ZHOU, B. ZHOU, C. ZHOU, G. ZHOU, H. ZHOU, J. ZHOU, K. ZHOU, R. ZHOU, X. ZHOU, Y. ZHOU, Z. ZHOU, B. ZHU, C. ZHU, G. ZHU, H. ZHU, W. ZHU, Y. ZHU, H. ZHUANG, X. ZHUANG, K. ZIENTARA-RYTTER, C. ZIMMERMANN, E. ZIVIANI, T. ZOLADEK, W. ZONG, D. ZOROV, A. ZORZANO, W. ZOU, Z. ZOU, S. ZURYN, W. ZWERSCHKE, B. BRAND-SABERI, C. KENCHAPPA, S. OSHIMA, Y. RONG, J. SLUIMER, and C. STALLINGS

Subjects
flux, macroautophagy, phagophore, stress, vacuole, Autophagosome, LC3, lysosome, neurodegeneration, cancer
Abstract

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.

Published
2021

17. Measurement of the Spectral Shape of the β -Decay of Xe137 to the Ground State of Cs137 in EXO-200 and Comparison with Theory

Author

T. Tolba, E. V. Hansen, Qing Xia, A. Jamil, A. Pocar, S. Thibado, V. Veeraraghavan, C. Chambers, R. DeVoe, Petr Vogel, David Leonard, R. MacLellan, Thomas Koffas, D. Fudenberg, W. M. Fairbank, M. Coon, J. Davis, M. J. Jewell, T. Daniels, F. Retiere, V.N. Stekhanov, L. J. Kaufman, J. Farine, Jouni Suhonen, A. Piepke, J. Todd, R. Tsang, M. J. Dolinski, Jens Dilling, O. Nusair, L. Darroch, R. Krücken, U. Wichoski, M. Hughes, I. Badhrees, K. Skarpaas, J. Hoessl, V. Belov, A. Robinson, T. Bhatta, A. S. Johnson, T. Ziegler, S. Feyzbakhsh, W. R. Cen, K. Murray, S. Al Kharusi, O. Ya. Zeldovich, G. S. Li, R. Gornea, Martin Breidenbach, M. Wagenpfeil, Gisela Anton, P. Hufschmidt, David A. Sinclair, P. C. Rowson, S. X. Wu, B. Mong, J. L. Vuilleumier, Arun Kumar Soma, C. Licciardi, A. Der Mesrobian-Kabakian, Yuehe Lin, S. J. Daugherty, A. Odian, L. Yang, David Moore, Y. Lan, S. Delaquis, Z. Li, Guofu Cao, Giorgio Gratta, A. Larson, T. Brunner, C. R. Hall, A. Dolgolenko, Thilo Michel, C. Jessiman, I. Ostrovskiy, P. Nakarmi, A. Craycraft, K. S. Kumar, B. T. Cleveland, A. Kuchenkov, O. Njoya, B. G. Lenardo, J. Watkins, A. Iverson, D. R. Yahne, T. McElroy, A. Karelin, Shu Li, S. Schmidt, L. J. Wen, Marc Weber, D. Fairbank, B. Veenstra, J. Kostensalo, J. Echevers, Peter Fierlinger, T. I. Totev, Gerrit Wrede, M. Tarka, Douglas H Beck, P. S. Barbeau, Y-R Yen, D. Ruddell, J. Runge, and P. Gautam

Subjects
Physics, Spectral shape analysis, General Physics and Astronomy, Nuclear data, Context (language use), Electron, 7. Clean energy, 01 natural sciences, Spectral line, 0103 physical sciences, Neutron source, Atomic physics, 010306 general physics, Ground state, Energy (signal processing)
Abstract

We report on a comparison between the theoretically predicted and experimentally measured spectra of the first-forbidden nonunique β-decay transition ^{137}Xe(7/2^{-})→^{137}Cs(7/2^{+}). The experimental data were acquired by the EXO-200 experiment during a deployment of an AmBe neutron source. The ultralow background environment of EXO-200, together with dedicated source deployment and analysis procedures, allowed for collection of a pure sample of the decays, with an estimated signal to background ratio of more than 99 to 1 in the energy range from 1075 to 4175 keV. In addition to providing a rare and accurate measurement of the first-forbidden nonunique β-decay shape, this work constitutes a novel test of the calculated electron spectral shapes in the context of the reactor antineutrino anomaly and spectral bump.

Published
2020

18. Measurement of the Spectral Shape of the β-Decay of ^{137}Xe to the Ground State of ^{137}Cs in EXO-200 and Comparison with Theory

Author

S, Al Kharusi, G, Anton, I, Badhrees, P S, Barbeau, D, Beck, V, Belov, T, Bhatta, M, Breidenbach, T, Brunner, G F, Cao, W R, Cen, C, Chambers, B, Cleveland, M, Coon, A, Craycraft, T, Daniels, L, Darroch, S J, Daugherty, J, Davis, S, Delaquis, A, Der Mesrobian-Kabakian, R, DeVoe, J, Dilling, A, Dolgolenko, M J, Dolinski, J, Echevers, W, Fairbank, D, Fairbank, J, Farine, S, Feyzbakhsh, P, Fierlinger, D, Fudenberg, P, Gautam, R, Gornea, G, Gratta, C, Hall, E V, Hansen, J, Hoessl, P, Hufschmidt, M, Hughes, A, Iverson, A, Jamil, C, Jessiman, M J, Jewell, A, Johnson, A, Karelin, L J, Kaufman, T, Koffas, J, Kostensalo, R, Krücken, A, Kuchenkov, K S, Kumar, Y, Lan, A, Larson, B G, Lenardo, D S, Leonard, G S, Li, S, Li, Z, Li, C, Licciardi, Y H, Lin, R, MacLellan, T, McElroy, T, Michel, B, Mong, D C, Moore, K, Murray, P, Nakarmi, O, Njoya, O, Nusair, A, Odian, I, Ostrovskiy, A, Piepke, A, Pocar, F, Retière, A L, Robinson, P C, Rowson, D, Ruddell, J, Runge, S, Schmidt, D, Sinclair, K, Skarpaas, A K, Soma, V, Stekhanov, J, Suhonen, M, Tarka, S, Thibado, J, Todd, T, Tolba, T I, Totev, R, Tsang, B, Veenstra, V, Veeraraghavan, P, Vogel, J-L, Vuilleumier, M, Wagenpfeil, J, Watkins, M, Weber, L J, Wen, U, Wichoski, G, Wrede, S X, Wu, Q, Xia, D R, Yahne, L, Yang, Y-R, Yen, O Ya, Zeldovich, and T, Ziegler

Abstract

We report on a comparison between the theoretically predicted and experimentally measured spectra of the first-forbidden nonunique β-decay transition ^{137}Xe(7/2^{-})→^{137}Cs(7/2^{+}). The experimental data were acquired by the EXO-200 experiment during a deployment of an AmBe neutron source. The ultralow background environment of EXO-200, together with dedicated source deployment and analysis procedures, allowed for collection of a pure sample of the decays, with an estimated signal to background ratio of more than 99 to 1 in the energy range from 1075 to 4175 keV. In addition to providing a rare and accurate measurement of the first-forbidden nonunique β-decay shape, this work constitutes a novel test of the calculated electron spectral shapes in the context of the reactor antineutrino anomaly and spectral bump.

Published
2020

20. Event Reconstruction in a Liquid Xenon Time Projection Chamber with an Optically-Open Field Cage

Author

B. Chana, N. Roy, L. Cao, O. Nusair, G. St-Hilaire, Douglas H Beck, R. Krücken, F. Nolet, E. Raguzin, P. A. Breur, T. McElroy, T. Bhatta, L. J. Kaufman, Gerard Visser, D. Goeldi, M. Coon, Eric W. Hoppe, F. Vachon, Z. Li, C. Chambers, Veljko Radeka, Cory T. Overman, L. J. Wen, J. L. Vuilleumier, Samuele Sangiorgio, L. Darroch, P. Gautam, P. Nakarmi, Kaixuan Ni, K. S. Kumar, A. De St. Croix, R. Tsang, Haijun Yang, E. V. Hansen, P. Lv, E. Caden, S. X. Wu, J. Hößl, P. S. Barbeau, Lorenzo Fabris, I. J. Arnquist, R. Gornea, P. C. Rowson, V.N. Stekhanov, X. S. Jiang, C. Licciardi, A. Jamil, A. House, A. Piepke, J. Todd, G. Gallina, S. Thibado, Y. Y. Ding, A. Der Mesrobian-Kabakian, N. Massacret, M. Heffner, R. MacLellan, S. Viel, M. Worcester, Thilo Michel, V. Veeraraghavan, Qing Xia, M. Hughes, G. Li, Sergio Ferrara, S. Al Kharusi, R. DeVoe, A. Pocar, M. Walent, B. G. Lenardo, Arun Kumar Soma, S. Feyzbakhsh, Y. Lan, G. S. Ortega, B. T. Cleveland, K. Deslandes, T. Brunner, A. Kuchenkov, M. Medina-Peregrina, Serge A. Charlebois, F. Retiere, David Moore, M. Chiu, J. P. Brodsky, M. Tarka, F. Edaltafar, T. Wager, K. G. Leach, Wei Wu, R.J. Newby, Qun-Yao Wang, Zhijun Ning, M. Oriunno, Aleksey E. Bolotnikov, K. Murray, Gisela Anton, K. Odgers, B. Mong, M. J. Dolinski, David Leonard, Thomas Koffas, W. M. Fairbank, T. Tsang, T. Stiegler, Jean-Francois Pratte, Angelo Dragone, M. Elbeltagi, John L. Orrell, T. Daniels, Wei Wei, H. Rasiwala, I. Ostrovskiy, Yu-Guang Zhou, S. Rescia, D. Fairbank, Guofu Cao, Mike Richman, O. Njoya, T. I. Totev, A. Iverson, K. Skarpaas Viii, Shu Li, Giorgio Gratta, U. Wichoski, L. Yang, T. Rossignol, M. J. Jewell, A. Craycraft, T. Ziegler, Gabriele Giacomini, J. Echevers, Jens Dilling, C.R. Natzke, I. Badhrees, A. Tidball, M. L. di Vacri, C. Vivo-Vilches, S. Parent, A. Odian, O. Zeldovich, R. Saldanha, M. Wagenpfeil, J. Dalmasson, X.L. Sun, J. B. Zhao, X. F. Wu, A. Larson, Ethan Brown, A. Karelin, J. Farine, V. Belov, and A. Robinson

Subjects
Physics, Nuclear and High Energy Physics, Scintillation, Photon, Time projection chamber, Physics - Instrumentation and Detectors, Field (physics), 010308 nuclear & particles physics, chemistry.chemical_element, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), 01 natural sciences, Xenon, chemistry, Double beta decay, Ionization, 0103 physical sciences, Atomic physics, 010306 general physics, Instrumentation, Event reconstruction
Abstract

nEXO is a proposed tonne-scale neutrinoless double beta decay ($0\nu\beta\beta$) experiment using liquid ${}^{136}Xe$ (LXe) in a Time Projection Chamber (TPC) to read out ionization and scintillation signals. Between the field cage and the LXe vessel, a layer of LXe ("skin" LXe) is present, where no ionization signal is collected. Only scintillation photons are detected, owing to the lack of optical barrier around the field cage. In this work, we show that the light originating in the skin LXe region can be used to improve background discrimination by 5% over previous published estimates. This improvement comes from two elements. First, a fraction of the $\gamma$-ray background is removed by identifying light from interactions with an energy deposition in the skin LXe. Second, background from ${}^{222}Rn$ dissolved in the skin LXe can be efficiently rejected by tagging the $\alpha$ decay in the ${}^{214}Bi-{}^{214}Po$ chain in the skin LXe., Comment: 11 pages, 12 figures

Published
2020
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21. Wavefront sensing and control in space-based coronagraph instruments using Zernike's phase-contrast method

Author

Nicholas Siegler, B. P. Crill, Garreth Ruane, John Steeves, Brian Kern, Byoung-Joon Seo, Robert Zimmer, J. Kent Wallace, Pin Chen, David Marx, Carl T. Coker, David Redding, Eduardo Bendek, A. J. Eldorado Riggs, Camilo Mejia Prada, J. Jewell, and Phillip K. Poon

Subjects
Time delay and integration, Zernike polynomials, Computer science, FOS: Physical sciences, Context (language use), 01 natural sciences, Deformable mirror, law.invention, 010309 optics, symbols.namesake, Optics, law, 0103 physical sciences, 010303 astronomy & astrophysics, Instrumentation, Coronagraph, Instrumentation and Methods for Astrophysics (astro-ph.IM), Wavefront, business.industry, Mechanical Engineering, Astronomy and Astrophysics, Wavefront sensor, Electronic, Optical and Magnetic Materials, Starlight, Space and Planetary Science, Control and Systems Engineering, symbols, Astrophysics - Instrumentation and Methods for Astrophysics, business, Physics - Optics, Optics (physics.optics)
Abstract

Future space telescopes with coronagraph instruments will use a wavefront sensor (WFS) to measure and correct for phase errors and stabilize the stellar intensity in high-contrast images. The HabEx and LUVOIR mission concepts baseline a Zernike wavefront sensor (ZWFS), which uses Zernike's phase contrast method to convert phase in the pupil into intensity at the WFS detector. In preparation for these potential future missions, we experimentally demonstrate a ZWFS in a coronagraph instrument on the Decadal Survey Testbed in the High Contrast Imaging Testbed facility at NASA's Jet Propulsion Laboratory. We validate that the ZWFS can measure low- and mid-spatial frequency aberrations up to the control limit of the deformable mirror, with surface height sensitivity as small as 1 pm, using a configuration similar to the HabEx and LUVOIR concepts. Furthermore, we demonstrate closed-loop control, resolving an individual DM actuator, with residuals consistent with theoretical models. In addition, we predict the expected performance of a ZWFS on future space telescopes using natural starlight from a variety of spectral types. The most challenging scenarios require ~1 hr of integration time to achieve picometer sensitivity. This timescale may be drastically reduced by using internal or external laser sources for sensing purposes. The experimental results and theoretical predictions presented here advance the WFS technology in the context of the next generation of space telescopes with coronagraph instruments., Comment: Accepted for publication in JATIS

Published
2020
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22. Measurements of electron transport in liquid and gas Xenon using a laser-driven photocathode

Author

R. Saldanha, I. Ostrovskiy, D. Kodroff, M. J. Dolinski, S. Rescia, John L. Orrell, T. Daniels, P. Gautam, D. Fairbank, Z. Li, E. Caden, E. V. Hansen, Gerard Visser, J. Watkins, Mike Richman, O. Njoya, R. MacLellan, He-Run Yang, A. Iverson, Triveni Rao, K. Skarpaas Viii, Liang Yang, R. Tsang, Gabriele Giacomini, A. Jamil, Pengpeng Lv, O. Nusair, R. Krücken, Shu Li, J. Echevers, Yu-Guang Zhou, Sergio Ferrara, B. Chana, Y. Lan, M. L. di Vacri, U. Wichoski, T. Wager, J. P. Brodsky, C. Vivo-Vilches, I. J. Arnquist, D. Beck, Thilo Michel, Y-R Yen, T. Tsang, T. Tolba, J. Runge, Yuehe Lin, T. Ziegler, Qun-Yao Wang, P. Nakarmi, Guofu Cao, M. Hughes, Jens Dilling, R. Fontaine, David Leonard, M. Heffner, Angelo Dragone, J. L. Vuilleumier, M. Walent, S. Al Kharusi, I. Badhrees, M. Tarka, Thomas Koffas, W. M. Fairbank, B. G. Lenardo, S. Viel, Arun Kumar Soma, T. Brunner, D. Goeldi, L. J. Kaufman, T. Stiegler, Samuele Sangiorgio, Xuan Wu, K. S. Kumar, S. Parent, M. Elbeltagi, M. Coon, K. G. Leach, David Moore, Wei Wei, Qing Xia, J. Farine, G. S. Ortega, Cory T. Overman, Wei Wu, R.J. Newby, P. C. Rowson, S. X. Wu, S. J. Daugherty, Serge A. Charlebois, A. House, G. St-Hilaire, S. Feyzbakhsh, P. S. Barbeau, A. Robinson, T. Bhatta, V. A. Belov, A.C. Odian, O. Zeldovich, Eric W. Hoppe, A. Piepke, J. Todd, L. Darroch, Y. Y. Ding, M. Oriunno, C. Chambers, A. Pocar, V.N. Stekhanov, B. T. Cleveland, T. Rossignol, A. Kuchenkov, M. J. Jewell, Veljko Radeka, X. S. Jiang, C. Licciardi, G. Gallina, A. Der Mesrobian-Kabakian, V. Veeraraghavan, A. Fucarino, Giorgio Gratta, M. Chiu, K. Murray, Gisela Anton, K. Odgers, E. Raguzin, J. Hossl, R. DeVoe, W. R. Cen, M. Medina-Peregrina, R. Gornea, F. Retiere, B. Mong, M. Wagenpfeil, J. Dalmasson, M. Ward, G. S. Li, X.L. Sun, J. B. Zhao, A. Larson, A. Craycraft, Ethan Brown, C.R. Natzke, A. Karelin, Jean-Francois Pratte, Z. Ning, T. I. Totev, A. De St. Croix, Lorenzo Fabris, N. Roy, L. Cao, F. Nolet, T. McElroy, F. Vachon, L. J. Wen, and Marc Weber

Subjects
Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, FOS: Physical sciences, chemistry.chemical_element, Electron, medicine.disease_cause, 7. Clean energy, 01 natural sciences, Photocathode, Xenon, Electric field, 0103 physical sciences, medicine, Nuclear Experiment (nucl-ex), 010306 general physics, Instrumentation, Nuclear Experiment, Physics, Argon, 010308 nuclear & particles physics, Instrumentation and Detectors (physics.ins-det), Photoelectric effect, chemistry, Quantum efficiency, High Energy Physics::Experiment, Atomic physics, Ultraviolet
Abstract

Measurements of electron drift properties in liquid and gaseous xenon are reported. The electrons are generated by the photoelectric effect in a semi-transparent gold photocathode driven in transmission mode with a pulsed ultraviolet laser. The charges drift and diffuse in a small chamber at various electric fields and a fixed drift distance of 2.0 cm. At an electric field of 0.5 kV/cm, the measured drift velocities and corresponding temperature coefficients respectively are 1 . 97 ± 0 . 04 m m ∕ μ s and ( − 0 . 69 ± 0 . 05 ) %/K for liquid xenon, and 1 . 42 ± 0 . 03 m m ∕ μ s and ( + 0 . 11 ± 0 . 01 ) %/K for gaseous xenon at 1.5 bar. In addition, we measure longitudinal diffusion coefficients of 25 . 7 ± 4 . 6 cm 2 /s and 149 ± 23 cm 2 /s, for liquid and gas, respectively. The quantum efficiency of the gold photocathode is studied at the photon energy of 4.73 eV in liquid and gaseous xenon, and vacuum. These charge transport properties and the behavior of photocathodes in a xenon environment are important in designing and calibrating future large scale noble liquid detectors.

Published
2019

24. Search for Neutrinoless Double-Beta Decay with the Complete EXO-200 Dataset

Author

D. R. Yahne, B. T. Cleveland, A. Kuchenkov, V.N. Stekhanov, C. Chambers, J. Watkins, J. Farine, C. R. Hall, A. Dolgolenko, D. Fudenberg, A. Craycraft, Peter Fierlinger, Gerrit Wrede, M. Tarka, J. Hoessl, Jens Dilling, D. Ruddell, V. Belov, I. Badhrees, L. Darroch, R. MacLellan, A. Robinson, A. Karelin, Qing Xia, Thilo Michel, J. Runge, Yuehe Lin, A. Odian, M. Hughes, R. DeVoe, M. Wagenpfeil, U. Wichoski, L. J. Kaufman, I. Ostrovskiy, Z. Li, B. G. Lenardo, Petr Vogel, A. Pocar, T. Ziegler, M. Danilov, T. Brunner, David Leonard, Giorgio Gratta, A. Piepke, J. Todd, A. Larson, O. Nusair, R. Krücken, P. S. Barbeau, O. Njoya, Thomas Koffas, K. S. Kumar, S. X. Wu, David Moore, J. L. Vuilleumier, W. M. Fairbank, O. Ya. Zeldovich, A. Iverson, M. J. Dolinski, P. Gautam, Shu Li, S. Schmidt, J. Davis, C. Jessiman, W. R. Cen, B. Mong, Y. Lan, R. Gornea, E. V. Hansen, T. Tolba, M. J. Jewell, F. Retiere, A. S. Johnson, Liang Yang, A. Jamil, M. Coon, Douglas H Beck, T. Daniels, Guofu Cao, Y-R Yen, S. Feyzbakhsh, Arun Kumar Soma, G. S. Li, P. Hufschmidt, David A. Sinclair, D. Fairbank, C. Licciardi, A. Der Mesrobian-Kabakian, J. Echevers, B. Veenstra, T. I. Totev, T. McElroy, L. J. Wen, Marc Weber, Martin Breidenbach, S. J. Daugherty, T. Bhatta, V. Veeraraghavan, K. Murray, Gisela Anton, P. C. Rowson, and S. Delaquis

Subjects
Physics, Q value, Resolution (electron density), Detector, General Physics and Astronomy, FOS: Physical sciences, 01 natural sciences, Lower limit, ddc, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), 0103 physical sciences, Sensitivity (control systems), Nuclear Experiment (nucl-ex), 010306 general physics, Nuclear Experiment, Energy (signal processing)
Abstract

A search for neutrinoless double-beta decay ($0\nu\beta\beta$) in $^{136}$Xe is performed with the full EXO-200 dataset using a deep neural network to discriminate between $0\nu\beta\beta$ and background events. Relative to previous analyses, the signal detection efficiency has been raised from 80.8% to 96.4$\pm$3.0% and the energy resolution of the detector at the Q-value of $^{136}$Xe $0\nu\beta\beta$ has been improved from $\sigma/E=1.23\%$ to $1.15\pm0.02\%$ with the upgraded detector. Accounting for the new data, the median 90% confidence level $0\nu\beta\beta$ half-life sensitivity for this analysis is $5.0 \cdot 10^{25}$ yr with a total $^{136}$Xe exposure of 234.1 kg$\cdot$yr. No statistically significant evidence for $0\nu\beta\beta$ is observed, leading to a lower limit on the $0\nu\beta\beta$ half-life of $3.5\cdot10^{25}$ yr at the 90% confidence level., Comment: v1, 7 pages, 5 figures; v2, fix references; v3, update to accepted version

Published
2019

25. Characterization of the Hamamatsu VUV4 MPPCs for nEXO

Author

P. Giampa, G. Li, D. Kodroff, M. Wagenpfeil, J. Dalmasson, Eric W. Hoppe, N. Roy, David Leonard, J. Blatchford, Thomas Koffas, E. V. Hansen, W. M. Fairbank, P. Gautam, B. T. Cleveland, K. Odgers, L. Cao, Liang Yang, A. Jamil, S. Rescia, T. Stiegler, E. Raguzin, M. Elbeltagi, R. MacLellan, A. Kuchenkov, Arun Kumar Soma, F. Nolet, X.L. Sun, T. Bhatta, D. Fairbank, J. B. Zhao, T. McElroy, A. Larson, Jean-Francois Pratte, B. Mong, F. Vachon, Marc Weber, G. St-Hilaire, P. Margetak, P. Nakarmi, M. Chiu, J. Farine, J. Echevers, C. Chambers, G. Zhang, M. Oriunno, P. C. Rowson, A. Robinson, I. J. Arnquist, S. X. Wu, Douglas H Beck, Qing Xia, U. Wichoski, Ethan Brown, A. House, K. Murray, Y-R Yen, L. Darroch, G. S. Ortega, R. DeVoe, Gisela Anton, T. Ziegler, O. Zeldovich, J. P. Brodsky, T. I. Totev, M. Heffner, Qun-Yao Wang, T. Tolba, W. R. Cen, S. J. Daugherty, A. De St. Croix, G. Gallina, R. Gornea, Serge A. Charlebois, T. Rossignol, Zhijun Ning, M. Tarka, M. J. Jewell, Lorenzo Fabris, J. L. Vuilleumier, M. Walent, John L. Orrell, T. Daniels, R. Tsang, B. G. Lenardo, T. Brunner, K. Skarpaas, P. Lv, V. Veeraraghavan, A. Karelin, J. Todd, Y. Y. Ding, O. Nusair, R. Krücken, Veljko Radeka, Wei Wu, R.J. Newby, M. Hughes, R. Saldanha, S. Al Kharusi, Giorgio Gratta, Martin Ward, He-Run Yang, David Moore, M. Alfaris, S. Feyzbakhsh, A. Craycraft, Y. Ito, L. J. Kaufman, Y. Lan, Yuehe Lin, Z. Li, Samuele Sangiorgio, Wei Wei, F. Retière, K. S. Kumar, J. Hößl, P. S. Barbeau, V. A. Belov, Thilo Michel, J. Kroeger, Xuan Wu, A. Pocar, A. Piepke, V.N. Stekhanov, D. Qiu, M. Coon, Cory T. Overman, T. Tsang, Angelo Dragone, Gabriele Giacomini, Jens Dilling, I. Badhrees, S. Parent, A. Odian, I. Ostrovskiy, Gerard Visser, Mike Richman, O. Njoya, A. Iverson, Shu Li, J. Watkins, M. Medina-Peregrina, X. S. Jiang, C. Licciardi, A. Der Mesrobian-Kabakian, Yu-Guang Zhou, Liangjian Wen, Luca Doria, Guofu Cao, Rejean Fontaine, and M. J. Dolinski

Subjects
010302 applied physics, Physics, Nuclear and High Energy Physics, Scintillation, Physics - Instrumentation and Detectors, 010308 nuclear & particles physics, Analytical chemistry, FOS: Physical sciences, chemistry.chemical_element, Instrumentation and Detectors (physics.ins-det), 01 natural sciences, Xenon, chemistry, 0103 physical sciences, Saturation (graph theory), Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Instrumentation, Photon detection, Dark current
Abstract

In this paper we report on the characterization of the Hamamatsu VUV4 (S/N: S13370-6152) Vacuum Ultra-Violet (VUV) sensitive Multi-Pixel Photon Counters (MPPC)s as part of the development of a solution for the detection of liquid xenon scintillation light for the nEXO experiment. Various MPPC features, such as: dark noise, gain, correlated avalanches, direct crosstalk and Photon Detection Efficiency (PDE) were measured in a dedicated setup at TRIUMF. MPPCs were characterized in the range 163 K ≤ T ≤ 233 K . At an over voltage of 3 . 1 ± 0 . 2 V and at T = 163 K we report a number of Correlated Avalanches (CAs) per pulse in the 1 μ s interval following the trigger pulse of 0 . 161 ± 0 . 005 . At the same settings the Dark-Noise (DN) rate is 0 . 137 ± 0 . 002 Hz/mm 2 . Both the number of CAs and the DN rate are within nEXO specifications. The PDE of the Hamamatsu VUV4 was measured for two different devices at T = 233 K for a mean wavelength of 189 ± 7 nm . At 3 . 6 ± 0 . 2 V and 3 . 5 ± 0 . 2 V of over voltage we report a PDE of 13 . 4 ± 2 . 6 % and 11 ± 2 % , corresponding to a saturation PDE of 14 . 8 ± 2 . 8 % and 12 . 2 ± 2 . 3 % , respectively. Both values are well below the 24 % saturation PDE advertised by Hamamatsu. More generally, the second device tested at 3 . 5 ± 0 . 2 V of over voltage is below the nEXO PDE requirement. The first one instead yields a PDE that is marginally close to meeting the nEXO specifications. This suggests that with modest improvements the Hamamatsu VUV4 MPPCs could be considered as an alternative to the FBK-LF Silicon Photo-Multipliers for the final design of the nEXO detector.

Published
2019

26. Male nursing students' experiences of simulation used to replace maternal-child clinical learning in Qatar

Author

Jason Hickey, Justine J. Jewell, and Daphne M. Kennedy

Subjects
Male, media_common.quotation_subject, education, MEDLINE, Fidelity, Context (language use), Experiential learning, Education, Interviews as Topic, 03 medical and health sciences, 0302 clinical medicine, Nursing, Pregnancy, Obstetric Nursing, Health care, Humans, 030212 general & internal medicine, Curriculum, Qatar, General Nursing, media_common, Cultural Characteristics, 030504 nursing, business.industry, Debriefing, Education, Nursing, Baccalaureate, Nurses, Male, Variety (cybernetics), Patient Simulation, Female, Students, Nursing, 0305 other medical science, Psychology, business
Abstract

Background In today's health care context, nurse educators teach with limited clinical placement availability, competition for available spaces and increasingly complex clients. Setting As part of the baccalaureate of nursing program at the University of Calgary in Qatar, students are required to complete 208 h of maternal-child clinical. Unfortunately, due to social and cultural norms in this predominantly Muslim country, male nursing students are prohibited from practicing with mothers and babies in Qatar. In order to address this need, we developed a fully simulated clinical practice module for these male students. Objectives The aim of the current study was to better understand the learning experiences of the students undertaking this experience. Design The authors developed and implemented a fully simulated, campus-based, maternity clinical experience that used a variety of levels of fidelity, incorporated the tenets of Kolb's (1984) experiential learning theory, and Jeffries' (2005) simulation design framework. Post-simulation debriefing sessions were recorded and transcribed. Typed weekly reflections were provided. All data was blinded. Participants A convenience sample of ten adult, male participants was obtained. Methods Using an inductive qualitative approach, researchers analyzed transcripts of debriefing sessions and reflective journals. Results The main themes were knowledge application, clinical judgement, communication, and crossing cultural barriers. Conclusions Themes from this study can be used to support and/or change existing practices in a way that supports learner-centered, experiential teaching practices.

Published
2019

27. Reflectance of Silicon Photomultipliers at Vacuum Ultraviolet Wavelengths

Author

E. Caden, S. Rescia, D. Fairbank, G. St-Hilaire, Thilo Michel, A. Craycraft, Jens Dilling, I. Badhrees, A. De St. Croix, X. S. Jiang, C. Licciardi, J. Farine, M. Walent, S. Feyzbakhsh, V. Belov, C.R. Natzke, B. G. Lenardo, A. Robinson, P. Nakarmi, A. Der Mesrobian-Kabakian, T. Brunner, L. Darroch, J. Echevers, Xuan Wu, S. Parent, A. Odian, A. Fucarino, Jean-Francois Pratte, Yu-Guang Zhou, E. Raguzin, T. Rossignol, Z. Li, O. Nusair, J. L. Vuilleumier, R. Krücken, M. Hughes, V. Veeraraghavan, M. J. Jewell, R. Saldanha, T. I. Totev, P. A. Breur, K. Skarpaas, Gerard Visser, S. Al Kharusi, I. Ostrovskiy, B. T. Cleveland, A. Kuchenkov, Liangjian Wen, Luca Doria, Guofu Cao, Samuele Sangiorgio, Wei Wei, K. S. Kumar, Mike Richman, David Moore, O. Njoya, A. Iverson, T. Bhatta, M. Chiu, G. S. Li, Thomas Tsang, Shu Li, Y. Lan, B. Chana, Douglas H Beck, L. Yang, M. Oriunno, J. P. Brodsky, P. S. Barbeau, He-Run Yang, R. DeVoe, K. Murray, J. Watkins, M. Tarka, Gisela Anton, R. Tsang, M. L. di Vacri, K. Odgers, M. J. Dolinski, M. Medina-Peregrina, C. Vivo-Vilches, F. Retiere, U. Wichoski, Sergio Ferrara, O. Zeldovich, K. G. Leach, T. Ziegler, R. Gornea, K. Deslandes, David Leonard, Giorgio Gratta, Thomas Koffas, W. M. Fairbank, Wei Wu, R.J. Newby, P. C. Rowson, T. Stiegler, M. Elbeltagi, Lorenzo Fabris, J. Hobl, A. House, N. Roy, L. Cao, F. Nolet, N. Massacret, T. McElroy, S. X. Wu, F. Vachon, C. Chambers, R. MacLellan, A. Pocar, V.N. Stekhanov, P. Gautam, F. Edaltafar, D. Goeldi, M. Coon, I. J. Arnquist, J. Runge, Cory T. Overman, M. Heffner, S. Viel, G. Gallina, Angelo Dragone, Gabriele Giacomini, P. Lv, A. Piepke, J. Todd, Y. Y. Ding, Veljko Radeka, T. Wager, Qun-Yao Wang, Zhijun Ning, E. V. Hansen, A. Jamil, Arun Kumar Soma, Qing Xia, S. Byrne Mamahit, Ethan Brown, A. Karelin, G. S. Ortega, M. Wagenpfeil, J. Dalmasson, X.L. Sun, J. B. Zhao, A. Larson, Serge A. Charlebois, John L. Orrell, T. Daniels, B. Mong, L. J. Kaufman, and Eric W. Hoppe

Subjects
Nuclear and High Energy Physics, Materials science, Physics - Instrumentation and Detectors, Silicon, chemistry.chemical_element, Photodetector, FOS: Physical sciences, 01 natural sciences, 7. Clean energy, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Xenon, Silicon photomultiplier, 0103 physical sciences, Wafer, Electrical and Electronic Engineering, 010308 nuclear & particles physics, business.industry, Instrumentation and Detectors (physics.ins-det), Nuclear Energy and Engineering, chemistry, Optoelectronics, Diffuse reflection, Photonics, business, Refractive index
Abstract

Characterization of the vacuum ultraviolet (VUV) reflectance of silicon photomultipliers (SiPMs) is important for large-scale SiPM-based photodetector systems. We report the angular dependence of the specular reflectance in a vacuum of SiPMs manufactured by Fondazionc Bruno Kessler (FBK) and Hamamatsu Photonics K.K. (HPK) over wavelengths ranging from 120 nm to 280 nm. Refractive index and extinction coefficient of the thin silicon-dioxide film deposited on the surface of the FBK SiPMs are derived from reflectance data of a FBK silicon wafer with the same deposited oxide film as SiPMs. The diffuse reflectance of SiPMs is also measured at 193 nm. We use the VUV spectral dependence of the optical constants to predict the reflectance of the FBK silicon wafer and FBK SiPMs in liquid xenon.

Published
2019
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28. Simulation of charge readout with segmented tiles in nEXO

Author

F. Retière, M. Medina-Peregrina, Venkatesh Veeraraghavan, J. Hößl, Gerard Visser, J. L. Vuilleumier, L. Darroch, M. Chiu, J. Watkins, V. A. Belov, Yang Haibo, A. De St. Croix, V. Radeka, D. Fairbank, T. McElroy, T. Bhatta, A. Pocar, D. S. Leonard, J. Echevers, E. Caden, A. Craycraft, R. DeVoe, Lorenzo Fabris, C. T. Overman, E. Raguzin, C. Vivo-Vilches, Qing Xia, M. J. Jewell, Xiaoyang Sun, R. Gornea, J. Dalmasson, S. Feyzbakhsh, P. Gautam, G. S. Ortega, A. Piepke, I. Ostrovskiy, P. Lv, M. Hughes, Thilo Michel, T. Ziegler, C.R. Natzke, Z. Ning, Xuan Wu, F. Vachon, Sergio Ferrara, Serge A. Charlebois, S. X. Wu, V.N. Stekhanov, M. Walent, S. Al Kharusi, J. B. Zhao, A. Larson, A. Der Mesrobian-Kabakian, A. E. Robinson, Mike Richman, B. G. Lenardo, T. Brunner, A. Fucarino, David Moore, N. Roy, L. Cao, F. Nolet, J. Todd, M. Heffner, D. Kodroff, T. Tolba, Jean-Francois Pratte, M. Oriunno, John L. Orrell, T. Daniels, B. Mong, Rejean Fontaine, Ethan Brown, Qian Wang, Y. Lan, K. Murray, G. Giacomini, T. Stiegler, O. Njoya, A. Iverson, K. Skarpaas Viii, Thomas Tsang, R. Saldanha, Shu Li, Y. Y. Ding, Z. Li, Gisela Anton, O. Zeldovich, Marc Weber, E. Hansen, A. Karelin, O. Nusair, R. Krücken, Jens Dilling, R. MacLellan, B. Chana, Giorgio Gratta, P. S. Barbeau, Yumei Zhou, I. Badhrees, R. Tsang, Martin Ward, T. I. Totev, D. Goeldi, M. Coon, Liangjian Wen, Douglas H Beck, Guofu Cao, Angelo Dragone, W. R. Cen, S. J. Daugherty, Thomas Koffas, Xiaoshan Jiang, W. M. Fairbank, M. Elbeltagi, Y-R Yen, S. Rescia, M. J. Dolinski, A. Odian, S. Parent, J. Runge, J. P. Brodsky, P. Nakarmi, U. Wichoski, S. Viel, C. Licciardi, G. Gallina, T. Rossignol, M. L. Di Vacri, L. J. Kaufman, Eric W. Hoppe, Liang Yang, A. Jamil, Arun Kumar Soma, Yuehe Lin, Samuele Sangiorgio, Wei Wei, K. S. Kumar, J. Farine, I. J. Arnquist, K. G. Leach, G. St-Hilaire, Wei Wu, R.J. Newby, P. C. Rowson, A. House, M. Tarka, G. Li, B. T. Cleveland, K. Odgers, A. Kuchenkov, M. Wagenpfeil, and C. Chambers

Subjects
Physics, Physics - Instrumentation and Detectors, Time projection chamber, 010308 nuclear & particles physics, Detector, chemistry.chemical_element, FOS: Physical sciences, Charge (physics), Instrumentation and Detectors (physics.ins-det), 01 natural sciences, 030218 nuclear medicine & medical imaging, Anode, Nuclear physics, 03 medical and health sciences, 0302 clinical medicine, Xenon, chemistry, Double beta decay, 0103 physical sciences, Beta (velocity), Sensitivity (control systems), Nuclear Experiment (nucl-ex), Nuclear Experiment, Instrumentation, Mathematical Physics
Abstract

nEXO is a proposed experiment to search for the neutrino-less double beta decay ($0\nu\beta\beta$) of $^{136}$Xe in a tonne-scale liquid xenon time projection chamber (TPC). The nEXO TPC will be equipped with charge collection tiles to form the anode. In this work, the charge reconstruction performance of this anode design is studied with a dedicated simulation package. A multi-variate method and a deep neural network are developed to distinguish simulated $0\nu\beta\beta$ signals from backgrounds arising from trace levels of natural radioactivity in the detector materials. These simulations indicate that the nEXO TPC with charge-collection tiles shows promising capability to discriminate the $0\nu\beta\beta$ signal from backgrounds. The estimated half-life sensitivity for $0\nu\beta\beta$ decay is improved by $\sim$20$~(32)\%$ with the multi-variate~(deep neural network) methods considered here, relative to the sensitivity estimated in the nEXO pre-conceptual design report.

Published
2019
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29. Reflectivity and PDE of VUV4 Hamamatsu SiPMs in Liquid Xenon

Author

Gerard Visser, M. Walent, B. G. Lenardo, T. Brunner, V. Veeraraghavan, T. Bhatta, Giorgio Gratta, F. Edaltafar, T. Rossignol, M. J. Jewell, J. Watkins, P. Nakarmi, Arun Kumar Soma, Ethan Brown, L. Darroch, O. Nusair, R. Krücken, S. X. Wu, David Leonard, J. Blatchford, E. Caden, Thomas Koffas, W. M. Fairbank, T. Stiegler, M. Elbeltagi, L. J. Kaufman, M. Hughes, X. S. Jiang, C. Licciardi, A. Craycraft, Eric W. Hoppe, S. Al Kharusi, A. Karelin, G. Gallina, P. Gautam, R. Saldanha, M. Chiu, J. L. Vuilleumier, T. Wager, A. Der Mesrobian-Kabakian, David Moore, C. Chambers, M. Oriunno, E. V. Hansen, M. Alfaris, M. Wagenpfeil, J. Dalmasson, Sergio Ferrara, R. MacLellan, Qun-Yao Wang, K. Murray, Gabriele Giacomini, I. J. Arnquist, Liang Yang, Y. Lan, U. Wichoski, C.R. Natzke, S. Feyzbakhsh, A. Jamil, Gisela Anton, J. Runge, Zhijun Ning, T. Ziegler, K. G. Leach, R. Tsang, X.L. Sun, J. B. Zhao, M. Heffner, K. Odgers, S. Viel, Wei Wu, R.J. Newby, A. Fucarino, A. Larson, Z. Li, B. Chana, Douglas H Beck, Samuele Sangiorgio, K. S. Kumar, Veljko Radeka, P. C. Rowson, A. House, N. Massacret, Jean-Francois Pratte, P. Lv, J. Todd, Angelo Dragone, B. Mong, Y. Y. Ding, M. Ward, T. I. Totev, G. S. Li, M. L. di Vacri, R. DeVoe, C. Vivo-Vilches, Qing Xia, S. Byrne Mamahit, G. S. Ortega, R. Fontaine, J. Farine, Serge A. Charlebois, John L. Orrell, T. Daniels, V. Belov, A. Robinson, N. Roy, L. Cao, F. Nolet, T. McElroy, F. Vachon, Marc Weber, A. De St. Croix, Lorenzo Fabris, B. T. Cleveland, D. Goeldi, M. Coon, A. Kuchenkov, Cory T. Overman, S. Rescia, D. Fairbank, G. St-Hilaire, J. P. Brodsky, He-Run Yang, A. Piepke, M. Tarka, V.N. Stekhanov, J. Echevers, A. Pocar, O. Zeldovich, Yu-Guang Zhou, Liangjian Wen, Luca Doria, Guofu Cao, Thilo Michel, Wei Wei, I. Ostrovskiy, M. J. Dolinski, E. Raguzin, P. A. Breur, Xuan Wu, Mike Richman, F. Retière, O. Njoya, A. Iverson, M. Medina-Peregrina, J. Hößl, K. Skarpaas Viii, P. S. Barbeau, Thomas Tsang, Shu Li, R. Gornea, Jens Dilling, I. Badhrees, S. Parent, and A. Odian

Subjects
Materials science, Physics - Instrumentation and Detectors, APDS, Physics::Instrumentation and Detectors, Photodetector, chemistry.chemical_element, FOS: Physical sciences, Photodetection, 01 natural sciences, 030218 nuclear medicine & medical imaging, law.invention, High Energy Physics - Experiment, 03 medical and health sciences, High Energy Physics - Experiment (hep-ex), 0302 clinical medicine, Silicon photomultiplier, Optics, Xenon, law, 0103 physical sciences, Specular reflection, Instrumentation, Mathematical Physics, Scintillation, 010308 nuclear & particles physics, business.industry, Instrumentation and Detectors (physics.ins-det), Wavelength, chemistry, business
Abstract

Understanding reflective properties of materials and photodetection efficiency (PDE) of photodetectors is important for optimizing energy resolution and sensitivity of the next generation neutrinoless double beta decay, direct detection dark matter, and neutrino oscillation experiments that will use noble liquid gases, such as nEXO, DARWIN, DarkSide-20k, and DUNE. Little information is currently available about reflectivity and PDE in liquid noble gases, because such measurements are difficult to conduct in a cryogenic environment and at short enough wavelengths. Here we report a measurement of specular reflectivity and relative PDE of Hamamatsu VUV4 silicon photomultipliers (SiPMs) with 50 micrometer micro-cells conducted with xenon scintillation light (~175 nm) in liquid xenon. The specular reflectivity at 15 deg. incidence of three samples of VUV4 SiPMs is found to be 30.4+/-1.4%, 28.6+/-1.3%, and 28.0+/-1.3%, respectively. The PDE at normal incidence differs by +/-8% (standard deviation) among the three devices. The angular dependence of the reflectivity and PDE was also measured for one of the SiPMs. Both the reflectivity and PDE decrease as the angle of incidence increases. This is the first measurement of an angular dependence of PDE and reflectivity of a SiPM in liquid xenon., Comment: 21 pages, 15 figures, 6 tables. As accepted by JINST

Published
2019
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30. Measurement of the scintillation and ionization response of liquid xenon at MeV energies in the EXO-200 experiment

Author

E. V. Hansen, D. Fudenberg, Liang Yang, A. Jamil, M. J. Jewell, L. Darroch, M. Wagenpfeil, Giorgio Gratta, M. J. Dolinski, P. Hufschmidt, David A. Sinclair, G. S. Li, Thilo Michel, D. Fairbank, J. L. Vuilleumier, M. Hughes, T. Bhatta, R. MacLellan, A.C. Odian, I. Ostrovskiy, A. Larson, T. Tolba, P. C. Rowson, C. Jessiman, A. Pocar, C. Licciardi, J. Echevers, B. Mong, O. Ya. Zeldovich, A. Der Mesrobian-Kabakian, R. Neilson, T. Brunner, S. Delaquis, L. J. Kaufman, T. McElroy, David Moore, A. Karelin, A. S. Johnson, J. Watkins, V. Veeraraghavan, L. J. Wen, Marc Weber, Arun Kumar Soma, V.N. Stekhanov, S. X. Wu, D. R. Yahne, C. R. Hall, R. DeVoe, A. Piepke, J. Todd, Martin Breidenbach, David Leonard, S. J. Daugherty, O. Njoya, J. Farine, A. Dolgolenko, A. Craycraft, D. Beck, Thomas Koffas, Qing Xia, D. Tosi, W. M. Fairbank, A. Iverson, C. Chambers, J. Hoessl, P. S. Barbeau, J. Runge, W. R. Cen, R. Gornea, M. Coon, Y-R Yen, Shu Li, S. Schmidt, Guofu Cao, A. Robinson, F. Retiere, V. A. Belov, O. Nusair, R. Krücken, Jens Dilling, B. Veenstra, K. Murray, I. Badhrees, T. I. Totev, P. Gautam, T. Daniels, J. Davis, Gisela Anton, Z. Li, U. Wichoski, T. Ziegler, B. G. Lenardo, Peter Fierlinger, Gerrit Wrede, M. Tarka, B. T. Cleveland, A. Kuchenkov, Y. Lan, S. Feyzbakhsh, Yuehe Lin, and K. S. Kumar

Subjects
Physics, Scintillation, Range (particle radiation), Physics - Instrumentation and Detectors, Photon, Argon, 010308 nuclear & particles physics, Physics::Instrumentation and Detectors, chemistry.chemical_element, FOS: Physical sciences, Electron, Instrumentation and Detectors (physics.ins-det), 01 natural sciences, 7. Clean energy, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), Xenon, chemistry, Electric field, Ionization, 0103 physical sciences, 010306 general physics
Abstract

Liquid xenon (LXe) is employed in a number of current and future detectors for rare event searches. We use the EXO-200 experimental data to measure the absolute scintillation and ionization yields generated by $\gamma$ interactions from $^{228}$Th (2615~keV), $^{226}$Ra (1764~keV) and $^{60}$Co (1332~keV and 1173~keV) calibration sources, over a range of electric fields. The $W$-value that defines the recombination-independent energy scale is measured to be $11.5~\pm~0.5$~(syst.)~$\pm~0.1$~(stat.) eV. These data are also used to measure the recombination fluctuations in the number of electrons and photons produced by the calibration sources at the MeV-scale, which deviate from extrapolations of lower-energy data. Additionally, a semi-empirical model for the energy resolution of the detector is developed, which is used to constrain the recombination efficiency, i.e., the fraction of recombined electrons that result in the emission of a detectable photon. Detailed measurements of the absolute charge and light yields for MeV-scale electron recoils are important for predicting the performance of future neutrinoless double beta decay detectors.

Published
2019
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32. Molecular and phenotypic characterisation of fenbendazole resistance in a field-derived isolate of Ostertagia ostertagi

Author

Dave J. Bartley, Leigh Andrews, Sian Mitchell, Alison A. Morrison, and Natalie J. Jewell

Subjects
0301 basic medicine, Benzimidazole, Veterinary medicine, 030231 tropical medicine, Drug Resistance, Cattle Diseases, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Ostertagiasis, Genotype, medicine, Animals, Anthelmintic, Anthelmintics, Ostertagia ostertagi, General Veterinary, Ostertagia, Fenbendazole, General Medicine, 030108 mycology & parasitology, biology.organism_classification, Isotype, Nematode, chemistry, Cattle, Parasitology, medicine.drug
Abstract

The prevalence of anthelmintic resistance in the bovine nematode Cooperia oncophora has been well documented globally but lack of efficacy against the more pathogenic nematode species Ostertagia ostertagi is less common. The sensitivity of an O. ostertagi isolate to the benzimidazole class of anthelmintic was investigated using classical parasitological techniques following apparent clinical failure of controlled release fenbendazole capsule administration in first season grazers at pasture. A controlled efficacy test (CET) was conducted in conjunction with sequencing of the β-tubulin isotype 1 gene of larvae pre- and post-fenbendazole administration. Twelve helminth-naive calves were infected experimentally with 20,000 third stage larvae; six received oral fenbendazole (7.5 mg/kg bodyweight) 28 days post infection. Total abomasal nematode burdens were compared between treatment and control groups to determine efficacy. Fenbendazole resistance in O. ostertagi was confirmed with a total treatment failure in reducing worm burden: efficacy of 0%. Sequence analysis of the β-tubulin isotype-1 gene from forty-five infective larvae from both control and treated groups was performed. The three commonest single nucleotide polymorphisms (SNPs) associated with benzimidazole resistance, namely F167Y, E198A and F200Y, were examined. The predominant resistance-associated SNPs were F200Y (78 % control and 79 % treated groups) and F167Y (remaining genotypes) and emphasises the importance of these SNPs in clinical disease in this isolate. The development of diagnostic molecular tools based on a characterised field-derived isolate of benzimidazole-resistant Ostertagia will enable future prevalence surveys to be undertaken to assess the possible risk posed by resistance in this economically important species.

Published
2021

33. Anaerobic Treatment of Apple Pomace and Wastewater

Author

David J. Malecki, William J. Jewell, and Thomas E. White

Subjects
Anaerobic digestion, Effluent limitation, Wastewater, Pomace, Environmental science, Anaerobic treatment, Pulp and paper industry, Retention time, Water use
Abstract

This chapter presents a study investigates the effect of solids retention time (SRT) on hydrolysis of diluted apple pomace. Apple pomace is the waste solids resulting from the production of apple juice or cider. The estimated disposal cost of the 1.5 million tons of pomace generated in the US each year exceeds $10 million. In addition to pomace, many processors discharge large quantities of wastewater generated during apple processing operations. Effluent limitation guidelines for the streams point source discharge generally require best conventional control technology. The most important factor having an impact on wastewater quality for juice manufacturers is quality of the raw fruit. For other products, the type of peeling operation employed, water use, and management attitude all have an important bearing on wastewater quality. Anaerobic digestion of apple wastes without nutrient or buffer addition results in a low cost alternative to disposal practices.

Published
2018

34. Deep Neural Networks for Energy and Position Reconstruction in EXO-200

Author

P. C. Rowson, Y.-R. Yen, A. Pocar, Douglas H Beck, J. C. Davis, W. Cree, T. Richards, Venkatesh Veeraraghavan, S. Delaquis, P. Hufschmidt, R. Krücken, M. Hughes, A. P. Waite, A. Karelin, Thomas Koffas, David Moore, W. M. Fairbank, Arun Kumar Soma, P. S. Barbeau, D. Fudenberg, A. Piepke, A. Craycraft, David A. Sinclair, M. J. Dolinski, Yuehe Lin, R. Bayerlein, Martin Breidenbach, G. S. Li, S. J. Daugherty, J. Dalmasson, V.N. Stekhanov, G. Wrede, K. S. Kumar, Stefan Schmidt, M. Tarka, A. Der Mesrobian-Kabakian, D. A. Harris, B. Mong, T. Daniels, C. R. Hall, Y. Lan, R. DeVoe, C. Chambers, J. Farine, Giorgio Gratta, Mikhail Danilov, U. Wichoski, A. S. Johnson, J. Todd, B. T. Cleveland, W. R. Cen, A. Kuchenkov, T. Ziegler, T. Tolba, A. Robinson, M. Wagenpfeil, R. MacLellan, M. Coon, J. L. Vuilleumier, E. V. Hansen, M. J. Jewell, J. Watkins, Liang Yang, D. S. Leonard, A. Jamil, S. Feyzbakhsh, Thilo Michel, Qing Xia, P. Fierlinger, C. Licciardi, Liangjian Wen, Guofu Cao, K. Murray, Gisela Anton, T. Brunner, L. J. Kaufman, O. Ya. Zeldovich, A. Dolgolenko, J. Hoessl, A. Schubert, Marc Weber, J. Daughhetee, F. Retière, J. B. Albert, V. A. Belov, R. Gornea, I. Ostrovskiy, O. Njoya, A. Iverson, Shu Li, Jens Dilling, I. Badhrees, A. Odian, and S. Kravitz

Subjects
Physics - Instrumentation and Detectors, Artificial neural network, 010308 nuclear & particles physics, Computer science, Calibration (statistics), Monte Carlo method, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), 01 natural sciences, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Position (vector), 0103 physical sciences, Pattern recognition (psychology), Waveform, Nuclear Experiment (nucl-ex), 010306 general physics, Instrumentation, Algorithm, Nuclear Experiment, Mathematical Physics, Energy (signal processing), Event reconstruction
Abstract

We apply deep neural networks (DNN) to data from the EXO-200 experiment. In the studied cases, the DNN is able to reconstruct the relevant parameters - total energy and position - directly from raw digitized waveforms, with minimal exceptions. For the first time, the developed algorithms are evaluated on real detector calibration data. The accuracy of reconstruction either reaches or exceeds what was achieved by the conventional approaches developed by EXO-200 over the course of the experiment. Most existing DNN approaches to event reconstruction and classification in particle physics are trained on Monte Carlo simulated events. Such algorithms are inherently limited by the accuracy of the simulation. We describe a unique approach that, in an experiment such as EXO-200, allows to successfully perform certain reconstruction and analysis tasks by training the network on waveforms from experimental data, either reducing or eliminating the reliance on the Monte Carlo., Accepted version. 33 pages, 28 figures

Published
2018

35. Search for nucleon decays with EXO-200

Author

M. Hughes, E. V. Hansen, A. P. Waite, Simon Johnston, T. Tolba, A.C. Odian, Liang Yang, A. Jamil, C. R. Hall, David Moore, O. Ya. Zeldovich, G. S. Li, T. Didberidze, B. T. Cleveland, L. J. Kaufman, Martin Breidenbach, R. MacLellan, M. Coon, S. J. Daugherty, R. DeVoe, R. H. Nelson, A. Pocar, U. Wichoski, Arun Kumar Soma, C. Chambers, P. C. Rowson, Petr Vogel, P. S. Barbeau, Guofu Cao, M. Danilov, M. J. Jewell, T. Ziegler, W. Cree, Yuehe Lin, David Leonard, V. A. Belov, Thomas Koffas, W. M. Fairbank, S. Delaquis, F. Retiere, K. S. Kumar, J. Zettlemoyer, S. Feyzbakhsh, V.N. Stekhanov, Douglas H Beck, J. C. Davis, Y-R Yen, A. Craycraft, B. Mong, D. Fudenberg, Samuel Homiller, J. Daughhetee, A. Piepke, K. Graham, M. J. Dolinski, C. Licciardi, A. Der Mesrobian-Kabakian, Peter Fierlinger, R. Bayerlein, Gerrit Wrede, A. Johnson, Thilo Michel, A. Karelin, Giorgio Gratta, M. Tarka, J. Farine, A. Dolgolenko, K. Murray, Y. Lan, J. Hoessl, P. Hufschmidt, M. Wagenpfeil, David A. Sinclair, Gisela Anton, A. Robinson, T. Walton, T. Brunner, Alexis G. Schubert, A. Kuchenkov, Justin Albert, R. Tsang, W. R. Cen, R. Gornea, L. J. Wen, Marc Weber, R. Krücken, Jens Dilling, I. Badhrees, T. Daniels, J.-L. Vuilleumier, S. Kravitz, I. Ostrovskiy, O. Njoya, Shu Li, and S. Schmidt

Subjects
Particle physics, Physics - Instrumentation and Detectors, Hadron, FOS: Physical sciences, Elementary particle, nucl-ex, 01 natural sciences, Atomic, High Energy Physics - Experiment, Nuclear physics, Particle decay, High Energy Physics - Experiment (hep-ex), Particle and Plasma Physics, 0103 physical sciences, Isotopes of xenon, Nuclear, Nuclear Experiment (nucl-ex), 010306 general physics, Nuclear Experiment, physics.ins-det, Physics, Quantum Physics, Isotope, 010308 nuclear & particles physics, hep-ex, Molecular, Fermion, Instrumentation and Detectors (physics.ins-det), Nuclear & Particles Physics, ddc, Baryon, Nucleon, Astronomical and Space Sciences
Abstract

A search for instability of nucleons bound in Xe136 nuclei is reported with 223 kg·yr exposure of Xe136 in the EXO-200 experiment. Lifetime limits of 3.3×1023 and 1.9×1023 yr are established for nucleon decay to Sb133 and Te133, respectively. These are the most stringent to date, exceeding the prior decay limits by a factor of 9 and 7, respectively.

Published
2018

36. VUV-sensitive Silicon Photomultipliers for Xenon Scintillation Light Detection in nEXO

Author

A. Jamil, T. Ziegler, P. Hufschmidt, G. Li, L. Lupin-Jimenez, T. Michel, I. Ostrovskiy, F. Retiere, J. Schneider, M. Wagenpfeil, A. Alamre, J. B. Albert, G. Anton, I. J. Arnquist, I. Badhrees, P. S. Barbeau, D. Beck, V. Belov, T. Bhatta, F. Bourque, J. P. Brodsky, E. Brown, T. Brunner, A. Burenkov, G. F. Cao, L. Cao, W. R. Cen, C. Chambers, S. A. Charlebois, M. Chiu, B. Cleveland, M. Coon, M. Cote, A. Craycraft, W. Cree, J. Dalmasson, T. Daniels, L. Darroch, S. J. Daugherty, J. Daughhetee, S. Delaquis, A. Der Mesrobian-Kabakian, R. DeVoe, J. Dilling, Y. Y. Ding, M. J. Dolinski, A. Dragone, J. Echevers, L. Fabris, D. Fairbank, W. Fairbank, J. Farine, S. Feyzbakhsh, R. Fontaine, D. Fudenberg, G. Gallina, G. Giacomini, R. Gornea, G. Gratta, E. V. Hansen, D. Harris, M. Hasan, M. Heffner, J. HoBl, E. W. Hoppe, A. House, M. Hughes, Y. Ito, A. Iverson, C. Jessiman, M. J. Jewell, X. S. Jiang, A. Karelin, L. J. Kaufman, T. Koffas, S. Kravitz, R. Krucken, A. Kuchenkov, K. S. Kumar, Y. Lan, A. Larson, D. S. Leonard, S. Li, Z. Li, C. Licciardi, Y. H. Lin, P. Lv, R. MacLellan, B. Mong, D. C. Moore, K. Murray, R. J. Newby, Z. Ning, O. Njoya, F. Nolet, O. Nusair, K. Odgers, A. Odian, M. Oriunno, J. L. Orrell, G. S. Ortega, C. T. Overman, S. Parent, A. Piepke, A. Pocar, J.-F. Pratte, D. Qiu, V. Radeka, E. Raguzin, T. Rao, S. Rescia, A. Robinson, T. Rossignol, P. C. Rowson, N. Roy, R. Saldanha, S. Sangiorgio, S. Schmidt, A. Schubert, D. Sinclair, K. Skarpaas, A. K. Soma, G. St-Hilaire, V. Stekhanov, T. Stiegler, X. L. Sun, M. Tarka, J. Todd, T. Tolba, T. I. Totev, R. Tsang, T. Tsang, F. Vachon, B. Veenstra, V. Veeraraghavan, G. Visser, J.-L. Vuilleumier, Q. Wang, J. Watkins, M. Weber, W. Wei, L. J. Wen, U. Wichoski, G. Wrede, S. X. Wu, W. H. Wu, Q. Xia, L. Yang, Y.-R. Yen, O. Zeldovich, X. Zhang, J. Zhao, and Y. Zhou

Subjects
Physics, Nuclear and High Energy Physics, Photomultiplier, Scintillation, Time projection chamber, Physics - Instrumentation and Detectors, 010308 nuclear & particles physics, business.industry, Noble gas, chemistry.chemical_element, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), Avalanche photodiode, 01 natural sciences, Optics, Silicon photomultiplier, Xenon, Nuclear Energy and Engineering, chemistry, Double beta decay, 0103 physical sciences, Electrical and Electronic Engineering, 010306 general physics, business
Abstract

Future tonne-scale liquefied noble gas detectors depend on efficient light detection in the VUV range. In the past years Silicon Photomultipliers (SiPMs) have emerged as a valid alternative to standard photomultiplier tubes or large area avalanche photodiodes. The next generation double beta decay experiment, nEXO, with a 5 tonne liquid xenon time projection chamber, will use SiPMs for detecting the $178\,\text{nm}$ xenon scintillation light, in order to achieve an energy resolution of $\sigma / Q_{\beta\beta} = 1\, \%$. This paper presents recent measurements of the VUV-HD generation SiPMs from Fondazione Bruno Kessler in two complementary setups. It includes measurements of the photon detection efficiency with gaseous xenon scintillation light in a vacuum setup and dark measurements in a dry nitrogen gas setup. We report improved photon detection efficiency at $175\,\text{nm}$ compared to previous generation devices, that would meet the criteria of nEXO. Furthermore, we present the projected nEXO detector light collection and energy resolution that could be achieved by using these SiPMs., Comment: 11 pages, 13 figures, 2 tables

Published
2018
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37. Treatment failure of lungworm in cattle

Author

Jeff Jones, Sian Mitchell, Anuschka Marsman, and Natalie J. Jewell

Subjects
040301 veterinary sciences, Drug Resistance, Cattle Diseases, Physiology, Disease, 0403 veterinary science, Feces, Weight loss, Grazing, Dictyocaulus Infections, medicine, Animals, Ingestion, Treatment Failure, Anthelmintics, Ivermectin, General Veterinary, Respiratory distress, business.industry, 0402 animal and dairy science, 04 agricultural and veterinary sciences, General Medicine, medicine.disease, 040201 dairy & animal science, Dictyocaulus, Bronchitis, Cattle, Female, Autopsy, medicine.symptom, business, Lungworm, Weight gain
Abstract

> We are now into the higher risk period of lungworm disease in cattle As we are now into the higher risk period of lungworm disease in cattle, we are writing to make colleagues aware of the diagnostic options, importance of correct treatment and the investigation of possible inefficacious treatments. Parasitic bronchitis, due to Dictyocaulus viviparus, can occur in grazing cattle of all ages. Clinical disease is characterised by coughing that may be accompanied by increased respiratory rate and effort, respiratory distress, milk drop and reduced weight gain/weight loss. Clinical signs are seen two to four weeks after the ingestion of infective larvae by non-immune cattle. Diagnostic testing for lungworm in live cattle is …

Published
2019

38. Searches for double beta decay of Xe134 with EXO-200

Author

L. J. Kaufman, Yuehe Lin, J. J. Russell, K. S. Kumar, T. Michel, Douglas H Beck, T. Daniels, Y-R Yen, J. Walton, M. Danilov, M. J. Jewell, I. Ostrovskiy, C. R. Hall, Y. Lan, David Leonard, A. S. Johnson, P. C. Rowson, J. Daughhetee, R. DeVoe, J. B. Albert, Petr Vogel, O. Ya. Zeldovich, A. Schubert, R. MacLellan, W. Cree, Thomas Koffas, W. M. Fairbank, J. Hoessl, O. Njoya, S. Delaquis, A.C. Odian, F. Retiere, P. Hufschmidt, Shu Li, R. Krücken, M. Hughes, Peter Fierlinger, S. Feyzbakhsh, J. Zettlemoyer, A. P. Waite, David A. Sinclair, A. Der Mesrobian-Kabakian, J. L. Vuilleumier, C. Licciardi, M. Tarka, P. S. Barbeau, A. Craycraft, K. Graham, Jens Dilling, I. Badhrees, C. Chambers, E. Smith, Martin Breidenbach, R. Bayerlein, A. Piepke, A. Karelin, Michael G. Marino, S. J. Daugherty, K. Murray, S. Johnston, David Moore, T. Didberidze, R. H. Nelson, B. T. Cleveland, Gisela Anton, T. Walton, A. Kuchenkov, J. Davis, M. Wagenpfeil, Guofu Cao, U. Wichoski, A. Dolgolenko, B. Mong, Giorgio Gratta, T. Ziegler, T. Tolba, L. J. Wen, Marc Weber, D. Fudenberg, M. J. Dolinski, S. Kravitz, Liang Yang, A. Jamil, R. Tsang, W. R. Cen, R. Gornea, M. Coon, A. Pocar, J. Farine, V. Belov, V.N. Stekhanov, and T. Brunner

Subjects
Physics, Particle physics, Isotope, 010308 nuclear & particles physics, chemistry.chemical_element, 01 natural sciences, Beta decay, Particle detector, 3. Good health, Nuclear physics, Xenon, chemistry, Double beta decay, 0103 physical sciences, Isotopes of xenon, Nuclear astrophysics, 010306 general physics, Radioactive decay
Abstract

Searches for double beta decay of ^(134)Xe were performed with EXO-200, a single-phase liquid xenon detector designed to search for neutrinoless double beta decay of ^(136)Xe. Using an exposure of 29.6 kg⋅yr, the lower limits of T^(2νββ_+(1/2) > 8.7×10^(20) yr and T^(0νββ)_(1/2) > 1.1×10^(23) yr at 90% confidence level were derived, with corresponding half-life sensitivities of 1.2×10^(21) yr and 1.9×10^(23) yr. These limits exceed those in the literature for ^(134)Xe, improving by factors of nearly 105 and 2 for the two antineutrino and neutrinoless modes, respectively.

Published
2017

39. An RF-only ion-funnel for extraction from high-pressure gases

Author

David Leonard, Thomas Koffas, W. M. Fairbank, T. Daniels, F. Retière, R. MacLellan, D. Fudenberg, J. Farine, P. S. Barbeau, I. Ostrovskiy, F. Leonard, R. Gornea, Marc Weber, D. Tosi, E. Smith, P. C. Rowson, Douglas H Beck, J. Walton, Y-R Yen, K. Graham, U. Wichoski, David A. Sinclair, J. L. Vuilleumier, M. Heffner, A. Craycraft, Monica Dunford, A. Piepke, M. Hughes, A. Sabourov, T. Tolba, A. Schubert, J. B. Albert, W. Feldmeier, L. J. Kaufman, David Moore, T. Didberidze, M. Tarka, B. Mong, D. J. Auty, C. Licciardi, V.N. Stekhanov, T. Brunner, Yuehe Lin, A. Karelin, Martin Breidenbach, S. J. Daugherty, C. Benitez-Medina, Ryan Killick, R. DeVoe, Lorenzo Fabris, C. Chambers, B. T. Cleveland, K. S. Kumar, A. Pocar, C. Ouellet, A. Kuchenkov, Giorgio Gratta, S. Kravitz, V. Varentsov, Liang Yang, Jens Dilling, M. Coon, T. N. Johnson, M. J. Jewell, A. Odian, K. Twelker, X. S. Jiang, R. Krücken, T. Walton, M. P. Rozo, M. J. Dolinski, Michael G. Marino, S. Johnston, P. Fierlinger, Liangjian Wen, and Guofu Cao

Subjects
Physics - Instrumentation and Detectors, Trace Amounts, Physics::Instrumentation and Detectors, FOS: Physical sciences, chemistry.chemical_element, 01 natural sciences, Ion, Xenon, Ionization, 0103 physical sciences, Nuclear Experiment (nucl-ex), Physical and Theoretical Chemistry, 010306 general physics, Nuclear Experiment, Instrumentation, Spectroscopy, Time projection chamber, Chemistry, 010401 analytical chemistry, Extraction (chemistry), Barium, Instrumentation and Detectors (physics.ins-det), Condensed Matter Physics, 0104 chemical sciences, 13. Climate action, Atomic physics, Bar (unit)
Abstract

An RF ion-funnel technique has been developed to extract ions from a high-pressure (10 bar) noble-gas environment into a vacuum (10(-6) mbar). Detailed simulations have been performed and a prototype has been developed for the purpose of extracting Ba-136 ions from Xe gas with high efficiency. With this prototype, ions have been extracted for the first time from high-pressure xenon gas and argon gas. Systematic studies have been carried out and compared to simulations. This demonstration of extraction of ions, with mass comparable to that of the gas generating the high-pressure, has applications to Ba tagging from a Xe-gas time-projection chamber for double-beta decay, as well as to the general problem of recovering trace amounts of an ionized element in a heavy (m > 40 u) carrier gas. (C) 2015 Elsevier B.V. All rights reserved.

Published
2015

40. Sensitivity and discovery potential of the proposed nEXO experiment to neutrinoless double beta decay

Author

J. L. Vuilleumier, B. Mong, M. Wagenpfeil, J. Dalmasson, A. Piepke, J. Todd, Y. Y. Ding, M. Heffner, Yuehe Lin, John L. Orrell, E. Raguzin, X.L. Sun, J. B. Zhao, C. T. Overman, R. Krücken, D. Qiu, Z. Li, Giorgio Gratta, A. Burenkov, M. Hasan, Arun Kumar Soma, L. J. Kaufman, R. DeVoe, S. J. Daugherty, Samuele Sangiorgio, M. Hughes, K. S. Kumar, V. Veeraraghavan, Y. Lan, Wei Wei, Petr Vogel, Rejean Fontaine, J. Daughhetee, A. Craycraft, U. Wichoski, Ethan Brown, F. Bourque, M. J. Jewell, M. Coon, D. Harris, Yu-Guang Zhou, T. Ziegler, T. Tolba, G. St-Hilaire, T. Tsang, Qun-Yao Wang, T. Stiegler, M. Chiu, J. P. Brodsky, David Moore, F. Retiere, Y. Ito, J. Zettlemoyer, Douglas H Beck, M. Oriunno, Zhijun Ning, S. Johnston, O. Zeldovich, G. Visser, A. Karelin, J. Hößl, A. Pocar, R. Tsang, T. Didberidze, S. Kravitz, Guofu Cao, T. N. Johnson, J. Schneider, P. Hufschmidt, E. V. Hansen, Y-R Yen, David A. Sinclair, F. Vachon, Ryan Killick, David Leonard, K. Murray, Liang Yang, R. J. Newby, Thomas Koffas, A. Jamil, D. Fudenberg, W. M. Fairbank, Gisela Anton, M. Côté, P. C. Rowson, T. Daniels, K. Graham, G. S. Ortega, B. T. Cleveland, M. J. Dolinski, V.N. Stekhanov, K. Odgers, Angelo Dragone, A. House, S. Rescia, A. Kuchenkov, W. Cree, Jean-Francois Pratte, Veljko Radeka, T. Rossignol, S. Feyzbakhsh, R. Saldanha, S. Delaquis, T. Brunner, W. R. Cen, Serge A. Charlebois, C. Licciardi, G. S. Li, R. Gornea, K. Skarpaas, G. Wrede, I. J. Arnquist, M. Tarka, Wei Wu, X. S. Jiang, A. Der Mesrobian-Kabakian, C. Chambers, A.C. Odian, G. Giacomini, A. Schubert, S. Parent, J. Farine, V. Belov, A. Robinson, L. Cao, F. Nolet, L. J. Wen, Marc Weber, S. X. Wu, Lorenzo Fabris, J. B. Albert, R. MacLellan, Thilo Michel, P. S. Barbeau, Jens Dilling, Xuan Zhang, I. Badhrees, I. Ostrovskiy, O. Njoya, A. Iverson, Shu Li, S. Schmidt, T. Rao, N. Roy, and E. W. Hoppe

Subjects
Physics, Time projection chamber, Physics - Instrumentation and Detectors, 010308 nuclear & particles physics, Active medium, Detector, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), 01 natural sciences, 7. Clean energy, 3. Good health, Nuclear physics, Homogeneous, 0103 physical sciences, Sensitivity (control systems), Nuclear Experiment (nucl-ex), 010306 general physics, Enriched Xenon Observatory, Nuclear Experiment, Order of magnitude
Abstract

The next-generation Enriched Xenon Observatory (nEXO) is a proposed experiment to search for neutrinoless double beta ($0\nu\beta\beta$) decay in $^{136}$Xe with a target half-life sensitivity of approximately $10^{28}$ years using $5\times10^3$ kg of isotopically enriched liquid-xenon in a time projection chamber. This improvement of two orders of magnitude in sensitivity over current limits is obtained by a significant increase of the $^{136}$Xe mass, the monolithic and homogeneous configuration of the active medium, and the multi-parameter measurements of the interactions enabled by the time projection chamber. The detector concept and anticipated performance are presented based upon demonstrated realizable background rates., Comment: v2 as published

Published
2017

41. Search for Neutrinoless Double-Beta Decay with the Upgraded EXO-200 Detector

Author

M. Wagenpfeil, S. Feyzbakhsh, S. Johnston, Martin Breidenbach, M. Coon, P. Fierlinger, Liangjian Wen, S. J. Daugherty, Guofu Cao, K. Graham, C. Licciardi, S. Kravitz, O. Ya. Zeldovich, R. Bayerlein, A. Piepke, R. H. Nelson, A. Schubert, U. Wichoski, Marc Weber, B. T. Cleveland, E. V. Hansen, B. Mong, P. C. Rowson, Giorgio Gratta, A. Kuchenkov, T. Ziegler, P. S. Barbeau, W. Cree, J. Davis, R. Krücken, S. Delaquis, K. Murray, David Leonard, R. Tsang, M. J. Jewell, A. Karelin, V. A. Belov, Gisela Anton, Liang Yang, A. Jamil, J. J. Russell, J. Farine, J. B. Albert, T. Walton, Thomas Koffas, W. M. Fairbank, M. Danilov, W. R. Cen, R. Gornea, J. Hoessl, Y. Lan, P. Hufschmidt, R. DeVoe, L. J. Kaufman, Douglas H Beck, J. Zettlemoyer, David A. Sinclair, Y-R Yen, J. Daughhetee, Yuehe Lin, C. Chambers, J. L. Vuilleumier, C. R. Hall, R. MacLellan, K. S. Kumar, A. Craycraft, T. Tolba, Thilo Michel, T. Brunner, A. S. Johnson, A. Dolgolenko, V.N. Stekhanov, A. Pocar, D. Fudenberg, M. Hughes, A. P. Waite, David Moore, T. Didberidze, Petr Vogel, F. Retiere, G. S. Li, M. J. Dolinski, A. Der Mesrobian-Kabakian, I. Ostrovskiy, O. Njoya, Shu Li, S. Schmidt, Jens Dilling, I. Badhrees, A. Odian, Gerrit Wrede, M. Tarka, and T. Daniels

Subjects
Cryostat, Physics, Particle physics, 010308 nuclear & particles physics, Detector, General Physics and Astronomy, chemistry.chemical_element, FOS: Physical sciences, Radon, 01 natural sciences, Confidence interval, High Energy Physics - Experiment, ddc, Nuclear physics, Lead shielding, High Energy Physics - Experiment (hep-ex), Upgrade, chemistry, Double beta decay, 0103 physical sciences, Nuclear astrophysics, Nuclear Experiment (nucl-ex), 010306 general physics, Nuclear Experiment
Abstract

Results from a search for neutrinoless double-beta decay $0\nu\beta\beta$ of $^{136}$Xe are presented using the first year of data taken with the upgraded EXO-200 detector. Relative to previous searches by EXO-200, the energy resolution of the detector has been improved to $\sigma/E$=1.23%, the electric field in the drift region has been raised by 50%, and a system to suppress radon in the volume between the cryostat and lead shielding has been implemented. In addition, analysis techniques that improve topological discrimination between $0\nu\beta\beta$ and background events have been developed. Incorporating these hardware and analysis improvements, the median 90% confidence level $0\nu\beta\beta$ half-life sensitivity after combining with the full data set acquired before the upgrade has increased 2-fold to $3.7 \times 10^{25}$ yr. No statistically significant evidence for $0\nu\beta\beta$ is observed, leading to a lower limit on the $0\nu\beta\beta$ half-life of $1.8\times10^{25}$ yr at the 90% confidence level., Comment: 6 pages, 4 figures, final version submitted to PRL

Published
2017
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42. Characterization of an Ionization Readout Tile for nEXO

Author

T. Stiegler, Douglas H Beck, R. Tsang, K. Murray, Gisela Anton, D. Fudenberg, R. Saldanha, Angelo Dragone, J. Todd, Y. Y. Ding, R. Krücken, Jochen M. Schneider, Y-R Yen, Jean-Francois Pratte, P. C. Rowson, K. Skarpaas, S. Kravitz, E. V. Hansen, Liang Yang, S. Feyzbakhsh, A. House, V. Veeraraghavan, R. J. Newby, A. Jamil, Ethan Brown, M. Chiu, W. Cree, A. Burenkov, S. Delaquis, M. Hughes, M. Côté, T. Daniels, Gabriele Giacomini, A. Pocar, Maulik R. Patel, M. Hasan, J. Farine, A. Karelin, R. DeVoe, Jens Dilling, Arun Kumar Soma, Zhijun Ning, T. Tolba, M. J. Jewell, I. Badhrees, David Moore, A. Robinson, T. Didberidze, B. Mong, M. Wagenpfeil, J. Dalmasson, I. J. Arnquist, Xiaoshan Jiang, Yuehe Lin, Veljko Radeka, A. Piepke, Gerrit Wrede, V.N. Stekhanov, J. B. Zhao, S. Parent, U. Wichoski, M. Oriunno, W. R. Cen, C. Chambers, R. Gornea, M. Heffner, A. Odian, D. Qiu, M. Tarka, S. Johnston, T. Ziegler, I. Ostrovskiy, John L. Orrell, E. Raguzin, Z. Li, T. Brunner, S. Rescia, S. X. Wu, Eric W. Hoppe, M. Coon, S. J. Daugherty, A. Schubert, O. Zeldovich, Cory T. Overman, G. Visser, Wei Wu, O. Njoya, A. Iverson, Triveni Rao, Y. Lan, Thomas Tsang, Shu Li, S. Schmidt, J. Daughhetee, Qian Wang, David Leonard, G. S. Ortega, Thomas Koffas, W. M. Fairbank, Samuele Sangiorgio, Giorgio Gratta, J. L. Vuilleumier, B. T. Cleveland, K. Odgers, Serge A. Charlebois, R. MacLellan, Yumei Zhou, Wei Wei, K. S. Kumar, Rejean Fontaine, A. Kuchenkov, P. Hufschmidt, David A. Sinclair, F. Bourque, J. P. Brodsky, G. St-Hilaire, D. Harris, Y. Ito, L. J. Kaufman, M. J. Dolinski, A. Craycraft, Liangjian Wen, Guofu Cao, G. S. Li, Thilo Michel, T. Rossignol, Xiaoyang Sun, C. Licciardi, A. Der Mesrobian-Kabakian, N. Roy, L. Cao, F. Nolet, F. Vachon, Marc Weber, F. Retière, J. B. Albert, X. Zhang, J. Hößl, P. S. Barbeau, V. A. Belov, and Lorenzo Fabris

Subjects
Physics - Instrumentation and Detectors, Materials science, Physics::Instrumentation and Detectors, chemistry.chemical_element, FOS: Physical sciences, STRIPS, 01 natural sciences, law.invention, Optics, Xenon, law, Ionization, 0103 physical sciences, Wafer, 010306 general physics, Instrumentation, Mathematical Physics, Time projection chamber, 010308 nuclear & particles physics, business.industry, Detector, Instrumentation and Detectors (physics.ins-det), Anode, chemistry, visual_art, visual_art.visual_art_medium, Tile, business
Abstract

A new design for the anode of a time projection chamber, consisting of a charge-detecting "tile", is investigated for use in large scale liquid xenon detectors. The tile is produced by depositing 60 orthogonal metal charge-collecting strips, 3~mm wide, on a 10~\si{\cm} $\times$ 10~\si{\cm} fused-silica wafer. These charge tiles may be employed by large detectors, such as the proposed tonne-scale nEXO experiment to search for neutrinoless double-beta decay. Modular by design, an array of tiles can cover a sizable area. The width of each strip is small compared to the size of the tile, so a Frisch grid is not required. A grid-less, tiled anode design is beneficial for an experiment such as nEXO, where a wire tensioning support structure and Frisch grid might contribute radioactive backgrounds and would have to be designed to accommodate cycling to cryogenic temperatures. The segmented anode also reduces some degeneracies in signal reconstruction that arise in large-area crossed-wire time projection chambers. A prototype tile was tested in a cell containing liquid xenon. Very good agreement is achieved between the measured ionization spectrum of a $^{207}$Bi source and simulations that include the microphysics of recombination in xenon and a detailed modeling of the electrostatic field of the detector. An energy resolution $\sigma/E$=5.5\% is observed at 570~\si{keV}, comparable to the best intrinsic ionization-only resolution reported in literature for liquid xenon at 936~V/\si{cm}., Comment: 18 pages, 13 figures, as published

Published
2017
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43. Impact des logos nutritionnels en face avant des emballages sur la sélection des tailles de portions : étude expérimentale

Author

Manon Egnell, J. Breda, J. Jewell, S. Hercberg, Pilar Galan, Mathilde Touvier, Chantal Julia, Emmanuelle Kesse-Guyot, and Mike Rayner

Subjects
0303 health sciences, 03 medical and health sciences, Nutrition and Dietetics, 030309 nutrition & dietetics, Endocrinology, Diabetes and Metabolism, Internal Medicine
Abstract

Discipline Epidemiologie. Introduction et but de l’etude En Europe, 3 logos nutritionnels en face avant des emballages, 2 mis en place par des gouvernements (Nutri-Score et Feux Tricolores Multiples (FTM)) et l’un cree par un consortium d’entreprises agro-alimentaires (Evolved Nutrition Label (ENL)), sont en discussion. Contrairement au Nutri-Score et aux FTM bases sur le contenu nutritionnel au 100 g d’un aliment, l’ENL est base sur une portion d’aliment, se traduisant alors par un etiquetage plus favorable specifiquement pour les aliments consommes en petites quantites. Or, l’effet de ces 3 logos sur la selection des tailles de portion est inconnu. L’objectif de l’etude etait donc d’evaluer l’effet de l’ENL, des FTM et du Nutri-Score sur la selection des tailles de portions, pour des aliments de moins bonne qualite nutritionnelle, en comparaison a l’absence de logo. Materiel et methodes Chaque participant, issu de la cohorte Nutri-Net Sante, etait expose a 3 categories alimentaires pour lesquelles une consommation en quantite limitee est recommandee (biscuits, fromages, pâtes a tartiner), et 4 produits par categorie ou les 4 situations d’etiquetage (3 logos et l’absence de logo comme controle) etaient representees. L’ordre d’apparition des produits ainsi que les combinaisons produit logo etaient randomisees. Pour chaque produit, le participant choisissait une taille de portions, parmi 4 photos standardisees de taille croissante, et le nombre de portions qu’ils consommeraient dans une occasion reelle de consommation. Des tests de Kruskall-Wallis etaient realises pour comparer les tailles de portions moyennes choisies entre les differents logos et le controle sans logo, ainsi qu’entre les logos. L’effet des logos sur la portion etait analyse a l’aide de modeles de regression logistique ordinale. Resultats et analyse statistique Compare a l’absence de logo, le Nutri-Score conduisait a la selection d’une portion significativement plus faible (OR = 0,76(0,74-0,76), p-value Conclusion Le Nutri-Score, suivi des FTM, semblent etre des outils efficaces pour augmenter la capacite du consommateur a identifier la qualite nutritionnelle des aliments et l’encourager a choisir des portions plus faibles pour des produits de moins bonne qualite nutritionnelle. En revanche, l’ENL semble avoir a un effet tres limite pour diminuer les portions des produits de moins bonne qualite nutritionnelle compare a l’absence de logo, et tendrait meme a accroitre la taille de portion pour les pâtes a tartiner.

Published
2019

44. Search for2νββdecay ofXe136to the01+excited state ofBa136with the EXO-200 liquid xenon detector

Author

A.C. Odian, I. Ostrovskiy, David Leonard, Thomas Koffas, W. M. Fairbank, O. Ya. Zeldovich, S. Feyzbakhsh, E. Smith, R. Krücken, D. Beck, M. Coon, D. Fudenberg, T. Brunner, J. King, O. Njoya, R. DeVoe, Peter Fierlinger, Justin Albert, K. Graham, Monica Dunford, A. Pocar, R. H. Nelson, U. Wichoski, M. Weber, T. Walton, Petr Vogel, M. Tarka, C. Licciardi, C. R. Hall, T. Tolba, C. Chambers, Q. Y. Xu, Ryan Killick, R. Tsang, M. Danilov, J. Walton, P. C. Rowson, D. J. Auty, A. Kuchenkov, Jens Dilling, J. Chaves, W. Feldmeier, F. Retiere, B. Mong, C.Y. Prescott, A. Craycraft, Martin Breidenbach, S. J. Daugherty, R. Gornea, L. J. Kaufman, T. Daniels, M. Hughes, J. Farine, S. Delaquis, A. P. Waite, Simon Johnston, J. C. Davis, Y-R Yen, Guofu Cao, T. N. Johnson, Yuehe Lin, Giorgio Gratta, J. L. Wood, David Moore, J. J. Russell, T. Didberidze, A. Der Mesrobian-Kabakian, J.-L. Vuilleumier, K. S. Kumar, B. T. Cleveland, Liang Yang, M. J. Dolinski, S. Kravitz, A. Piepke, A. Burenkov, A. Karelin, A. Johnson, V.N. Stekhanov, David A. Sinclair, T. A. Winick, M. J. Jewell, K. Twelker, L. J. Wen, Alexis G. Schubert, R. MacLellan, M. G. Marino, P. S. Barbeau, V. A. Belov, and A. Dolgolenko

Subjects
Semileptonic decay, Physics, 010308 nuclear & particles physics, Detector, chemistry.chemical_element, 7. Clean energy, 01 natural sciences, Lower limit, Xenon, chemistry, Excited state, 0103 physical sciences, Single phase, Atomic physics, Neutrino, 010306 general physics, Ground state
Abstract

EXO-200 is a single phase liquid xenon detector designed to search for neutrinoless ββ decay of ^(136)Xe to the ground state of ^(136)Ba. We report here on a search for the two-neutrino ββ decay of 136Xe to the first 0+ excited state, 0^+_1, of ^(136)Ba based on a 100 kg yr exposure of ^(136)Xe. Using a specialized analysis employing a machine learning algorithm, we obtain a 90% CL half-life sensitivity of 1.7 × 10^(24) yr. We find no statistically significant evidence for the 2νββ decay to the excited state resulting in a lower limit of T^(2ν)_(1/2)(0^+ → 0^+_1) > 6.9 ×10^(23) yr at 90% CL. This observed limit is consistent with the estimated half-life of 2.5 × 10^(25) yr.

Published
2016

45. Electronic patient-reported outcomes from home in patients recovering from major gynecologic cancer surgery: A prospective study measuring symptoms and health-related quality of life

Author

Jeanne Carter, Kaity Chang, Nadeem R. Abu-Rustum, Vaagn Andikyan, Dennis S. Chi, Youssef A. Rezk, Elizabeth J. Jewell, Renee A. Cowan, Rudy S. Suidan, M. Heather Einstein, Oliver Zivanovic, and Ethan Basch

Subjects
Adult, medicine.medical_specialty, Adolescent, Genital Neoplasms, Female, medicine.medical_treatment, education, Article, 03 medical and health sciences, 0302 clinical medicine, Patient satisfaction, Quality of life, Surveys and Questionnaires, Laparotomy, Gynecologic cancer, medicine, Humans, In patient, Patient Reported Outcome Measures, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Aged, Health related quality of life, business.industry, Obstetrics and Gynecology, Workload, Middle Aged, Surgery, Oncology, Patient Satisfaction, 030220 oncology & carcinogenesis, Quality of Life, Female, business
Abstract

Purpose We previously reported on the feasibility of a Web-based system to capture patient-reported outcomes (PROs) in the immediate postoperative period. The purpose of this study was to update the experience of these patients and assess patient and provider satisfaction and feedback regarding the system. Methods This is a prospective cohort study of patients scheduled to undergo laparotomy for presumed gynecologic malignancy. Patients completed a Web-based Symptom Tracking and Reporting (STAR) questionnaire preoperatively and weekly during a 6-week postoperative period. Email alerts were sent to study nurses when concerning patient responses were entered. The patient and the nurse assessments of STAR's usefulness were measured via an exit survey. Results The study enrolled 96 eligible patients. Of these, 71 patients (74%) completed at least four of seven total sessions. Of the patients who completed the exit satisfaction survey, 98% found STAR easy to use; 84% found it useful; and 82% would recommend it to other patients. Despite positive feedback from patients, clinical personnel found that the STAR system increased their current workload without enhancing patient care. Conclusions Application of an electronic program for PROs in those recovering from major gynecologic cancer surgery is feasible, and acceptable to most patients. While most clinicians did not find STAR clinically helpful, the majority of patients reported a positive experience with the system and would recommend its use. The program helped many patients feel more empowered in their postoperative recovery.

Published
2016
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46. An Optimal Energy Estimator to Reduce Correlated Noise for the EXO-200 Light Readout

Author

A. Der Mesrobian-Kabakian, Yuehe Lin, A. Pocar, S. Kravitz, Monica Dunford, C. Y. Prescott, M. Coon, R. Tsang, A. Craycraft, J. L. Wood, V.N. Stekhanov, Liang Yang, K. S. Kumar, W. R. Cen, R. Gornea, K. Graham, J. J. Russell, J. Farine, M. Danilov, Peter Fierlinger, A. Karelin, A. Dolgolenko, R. DeVoe, Douglas H Beck, David Leonard, V. Belov, M. Tarka, Thomas Koffas, W. M. Fairbank, Y-R Yen, Michael G. Marino, T. Daniels, S. Johnston, T. Brunner, C. G. Davis, O. Ya. Zeldovich, T. Walton, Liangjian Wen, A. S. Johnson, Guofu Cao, Martin Breidenbach, S. J. Daugherty, L. J. Kaufman, A. Burenkov, B. Mong, E. Smith, R. Krücken, F. Retière, J. B. Albert, David A. Sinclair, A. Schubert, Ryan Killick, R. H. Nelson, M. J. Dolinski, U. Wichoski, B. T. Cleveland, P. S. Barbeau, T. Tolba, A. Kuchenkov, S. Feyzbakhsh, Marc Weber, C. Licciardi, C. R. Hall, J. L. Vuilleumier, J. Walton, A. Piepke, Giorgio Gratta, W. Feldmeier, J. Davis, M. Hughes, A. P. Waite, M. J. Jewell, K. Twelker, David Moore, T. Didberidze, T. N. Johnson, D. Fudenberg, R. MacLellan, C. Chambers, P. C. Rowson, S. Delaquis, Jens Dilling, A. Odian, I. Ostrovskiy, and O. Njoya

Subjects
Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, FOS: Physical sciences, 01 natural sciences, Noise (electronics), Particle detector, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Optics, Double beta decay, 0103 physical sciences, Nuclear Experiment (nucl-ex), 010306 general physics, Instrumentation, Nuclear Experiment, Mathematical Physics, Physics, Scintillation, 010308 nuclear & particles physics, business.industry, Detector, Estimator, Instrumentation and Detectors (physics.ins-det), High Energy Physics::Experiment, business, Energy (signal processing), Radioactive decay
Abstract

The energy resolution of the EXO-200 detector is limited by electronics noise in the measurement of the scintillation response. Here we present a new technique to extract optimal scintillation energy measurements for signals split across multiple channels in the presence of correlated noise. The implementation of these techniques improves the energy resolution of the detector at the neutrinoless double beta decay Q-value from $\left[1.9641\pm 0.0039\right]\%$ to $\left[1.5820\pm 0.0044\right]\%$., Comment: 21 pages, 8 figures, 1 table

Published
2016
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48. Study of silicon photomultiplier performance in external electric fields

Author

A. Alamre, T. Stiegler, John L. Orrell, T. Daniels, M. Côté, J. Schneider, Z. Li, N. Roy, L. Cao, F. Nolet, M. Oriunno, M. Hughes, Ethan Brown, J. Farine, D. Fairbank, D. Qiu, Y. Ito, M. Coon, Thilo Michel, Qing Xia, V.N. Stekhanov, C. T. Overman, M. Chiu, G. S. Ortega, A. Karelin, A. Pocar, D. S. Leonard, T. Tolba, Venkatesh Veeraraghavan, J. Hößl, Marc Weber, S. Kravitz, Yuehe Lin, David Moore, Y. Lan, R. DeVoe, Serge A. Charlebois, K. Murray, A. Craycraft, J. Echevers, Gisela Anton, M. Wagenpfeil, J. Dalmasson, T. Brunner, E. Raguzin, O. Nusair, Jens Dilling, R. Krücken, Z. Ning, Samuele Sangiorgio, Wei Wei, K. S. Kumar, S. X. Wu, Gerard Visser, P. S. Barbeau, D. A. Harris, A. Der Mesrobian-Kabakian, J. B. Zhao, A. Larson, D. Fudenberg, O. Zeldovich, A. Piepke, I. Badhrees, Angelo Dragone, M. J. Jewell, F. Vachon, Rejean Fontaine, Jean-Francois Pratte, R. Saldanha, L. Darroch, D. Kodroff, B. Veenstra, F. Bourque, S. Parent, S. Rescia, Lorenzo Fabris, T. Bhatta, A. Odian, S. J. Daugherty, J. Watkins, I. Ostrovskiy, R. MacLellan, G. Giacomini, J. P. Brodsky, T. I. Totev, Stefan Schmidt, R. Tsang, O. Njoya, A. Iverson, Triveni Rao, K. Skarpaas Viii, T. Rossignol, G. Wrede, B. Mong, Thomas Tsang, Shu Li, P. Fierlinger, W. R. Cen, Liangjian Wen, Guofu Cao, L. J. Kaufman, A. E. Robinson, M. Tarka, J. B. Albert, Qian Wang, G. Li, S. Feyzbakhsh, Giorgio Gratta, Yumei Zhou, M. J. Dolinski, P. Hufschmidt, David A. Sinclair, B. T. Cleveland, K. Odgers, A. Kuchenkov, U. Wichoski, G. St-Hilaire, C. Licciardi, V. Radeka, T. Ziegler, Thomas Koffas, W. M. Fairbank, Xilei Sun, I. J. Arnquist, Wei Wu, R.J. Newby, P. C. Rowson, A. House, W. Cree, S. Delaquis, Xiaoshan Jiang, C. Chambers, G. Gallina, P. Lv, J. Todd, Y. Y. Ding, E. V. Hansen, Liang Yang, A. Jamil, Douglas H Beck, A. Burenkov, Y-R Yen, J. L. Vuilleumier, Arun Kumar Soma, C. Jessiman, M. K. Moe, Eric W. Hoppe, M. Heffner, J. Daughhetee, R. Gornea, F. Retière, and V. A. Belov

Subjects
010302 applied physics, Physics - Instrumentation and Detectors, Materials science, 010308 nuclear & particles physics, business.industry, FOS: Physical sciences, Observable, Instrumentation and Detectors (physics.ins-det), 01 natural sciences, 7. Clean energy, Silicon photomultiplier, Electric field, 0103 physical sciences, Optoelectronics, business, Instrumentation, Photon detection, Mathematical Physics
Abstract

We report on the performance of silicon photomultiplier (SiPM) light sensors operating in electric field strength up to 30 kV/cm and at a temperature of 149K, relative to their performance in the absence of an external electric field. The SiPM devices used in this study show stable gain, photon detection efficiency, and rates of correlated pulses, when exposed to external fields, within the estimated uncertainties. No observable physical damage to the bulk or surface of the devices was caused by the exposure., Comment: 16 pages, 12 figures, 2 tables and two conferences (INPC2016 and TIPP2017)

Published
2018

49. BAYESIAN ANALYSIS OF WHITE NOISE LEVELS IN THE FIVE-YEAR WMAP DATA

Author

B. D. Wandelt, J. Jewell, Nicolaas E. Groeneboom, H. K. Eriksen, G. Huey, and K. M. Górski

Subjects
Physics, media_common.quotation_subject, Bayesian probability, Cosmic microwave background, Astronomy and Astrophysics, Astrophysics, White noise, CMB cold spot, Noise, symbols.namesake, Space and Planetary Science, Sky, Range (statistics), symbols, Algorithm, media_common, Gibbs sampling
Abstract

We develop a new Bayesian method for estimating white noise levels in CMB sky maps, and apply this algorithm to the 5-year WMAP data. We assume that the amplitude of the noise RMS is scaled by a constant value, alpha, relative to a pre-specified noise level. We then derive the corresponding conditional density, P(alpha | s, Cl, d), which is subsequently integrated into a general CMB Gibbs sampler. We first verify our code by analyzing simulated data sets, and then apply the framework to the WMAP data. For the foreground-reduced 5-year WMAP sky maps and the nominal noise levels initially provided in the 5-year data release, we find that the posterior means typically range between alpha=1.005 +- 0.001 and alpha=1.010 +- 0.001 depending on differencing assembly, indicating that the noise level of these maps are biased low by 0.5-1.0%. The same problem is not observed for the uncorrected WMAP sky maps. After the preprint version of this letter appeared on astro-ph., the WMAP team has corrected the values presented on their web page, noting that the initially provided values were in fact estimates from the 3-year data release, not from the 5-year estimates. However, internally in their 5-year analysis the correct noise values were used, and no cosmological results are therefore compromised by this error. Thus, our method has already been demonstrated in practice to be both useful and accurate.

Published
2009

50. A MARKOV CHAIN MONTE CARLO ALGORITHM FOR ANALYSIS OF LOW SIGNAL-TO-NOISE COSMIC MICROWAVE BACKGROUND DATA

Author

K. M. Górski, B. D. Wandelt, G. Huey, H. K. Eriksen, J. Jewell, and I. J. O'Dwyer

Subjects
Physics, media_common.quotation_subject, Cosmic microwave background, Spectral density, Astronomy and Astrophysics, Sample (statistics), Markov chain Monte Carlo, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, Signal, Statistics::Computation, symbols.namesake, Space and Planetary Science, Sky, Simple (abstract algebra), symbols, Algorithm, Gibbs sampling, media_common
Abstract

We present a new Monte Carlo Markov Chain algorithm for CMB analysis in the low signal-to-noise regime. This method builds on and complements the previously described CMB Gibbs sampler, and effectively solves the low signal-to-noise inefficiency problem of the direct Gibbs sampler. The new algorithm is a simple Metropolis-Hastings sampler with a general proposal rule for the power spectrum, C_l, followed by a particular deterministic rescaling operation of the sky signal. The acceptance probability for this joint move depends on the sky map only through the difference of chi-squared between the original and proposed sky sample, which is close to unity in the low signal-to-noise regime. The algorithm is completed by alternating this move with a standard Gibbs move. Together, these two proposals constitute a computationally efficient algorithm for mapping out the full joint CMB posterior, both in the high and low signal-to-noise regimes.

Published
2009

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