Search

Lifetime measurements in $$^{178}$$ 178 Pt with excited states de-exciting through $$\gamma $$ γ -ray transitions and internal electron conversions have been performed. Ionic charges were selected by the in-flight mass separator MARA and measured at the focal plane in coincidence with the $$4_1^+\rightarrow 2_1^+$$ 4 1 + → 2 1 + $$257\,$$ 257 keV $$\gamma $$ γ -ray transition detected using the JUROGAM 3 spectrometer. The resulting charge-state distributions were analysed using the differential decay curve method (DDCM) framework to obtain a lifetime value of 430(20) ps for the $$2_1^+$$ 2 1 + state. This work builds on a method that combines the charge plunger technique with the DDCM analysis. As an alternative analysis, ions were selected in coincidence with the $$^{178}$$ 178 Pt alpha decay ($$E_{\mathrm {alpha}} = 5.458(5)$$ E alpha = 5.458 ( 5 ) MeV) at the focal plane. Lifetime information was obtained by fitting a two-state Bateman equation to the decay curve with the lifetime of individual states defined by a single quadrupole moment. This yielded a lifetime value of 430(50) ps for the $$2_1^+$$ 2 1 + state, and 54(6) ps for the $$4_1^+$$ 4 1 + state. An analysis method based around the Bateman equation will become especially important when using the charge plunger method for the cases where utilising coincidences between prompt $$\gamma $$ γ rays and recoils is not feasible.

A nuclear spectroscopy experiment was conducted to study α-decay chains stemming from isotopes of flerovium (element Z=114). An upgraded TASISpec decay station was placed behind the gas-filled separator TASCA at the GSI Helmholtzzentrum fur Schwerionenforschung in Darmstadt, Germany. The fusion-evaporation reactions ^{48}Ca+^{242}Pu and ^{48}Ca+^{244}Pu provided a total of 32 flerovium-candidate decay chains, of which two and eleven were firmly assigned to ^{286}Fl and ^{288}Fl, respectively. A prompt coincidence between a 9.60(1)-MeV α particle event and a 0.36(1)-MeV conversion electron marked the first observation of an excited state in an even-even isotope of the heaviest man-made elements, namely ^{282}Cn. Spectroscopy of ^{288}Fl decay chains fixed Q_{α}=10.06(1) MeV. In one case, a Q_{α}=9.46(1)-MeV decay from ^{284}Cn into ^{280}Ds was observed, with ^{280}Ds fissioning after only 518 μs. The impact of these findings, aggregated with existing data on decay chains of ^{286,288}Fl, on the size of an anticipated shell gap at proton number Z=114 is discussed in light of predictions from two beyond-mean-field calculations, which take into account triaxial deformation.

An upgraded TASISpec setup, with the addition of a veto DSSD and the new Compex detector-germanium array, has been employed with the gas-filled recoil separator TASCA at the GSI Helmholtzzentrum für Schwerionenforschung Darmstadt, to study flerovium (element 114) decay chains. The detector upgrades along with development of new analytical techniques have improved the sensitivity of the TASISpec setup for measuring α-photon coincidences. These improvements have been assessed with test reactions. The reaction 48Ca+206,207Pb was used for verification of experimental parameters such as transmission to implantation DSSD and target-segment to α-decay correlations. The reaction 48Ca+ nat Hf was used to produce several short-lived nuclei with multiple-α decay chains to investigate pile-up event deconvolution.

A Triple-foil differential Plunger for Exotic Nuclei (TPEN) has been developed to measure the lifetimes of excited states in nuclei with small production cross-sections. TPEN utilises one target foil and two degrader foils to make differential lifetime measurements: directly determining the decay function and its derivative at a single plunger distance setting. The direct measurement of the decay function and its derivative removes the requirement to measure γ -ray intensities at several target-to-degrader distances, thereby reducing the beam-time required relative to a conventional plunger with a single-degrader foil. This paper describes the commissioning of TPEN in the lifetime measurement of the first excited 4 + state in 156Dy using this differential lifetime technique. The 46(2) ps measured lifetime was found to be in good agreement with the 45.6(5) ps deduced from a previous high-statistics experiment using a conventional two-foil plunger. A comparison between the differential mode with TPEN, and that using TPEN as a conventional two-foil plunger reveals that it achieves the same statistical accuracy with a ∼ 4 -fold reduction in beam-time in the differential mode, for the reaction and experimental setup used in this work. TPEN opens up new opportunities to study exotic nuclei with lower production cross-sections that were previously not accessible.

A charge plunger device has been commissioned based on the DPUNS plunger (Taylor et al., 2013) using the in-flight mass separator MARA at the University of Jyvaskyla. The 152 Sm (32 S ,4 n )180 Pt reaction was used to populate excited states in 180 Pt . A lifetime measurement of the 2 1 + state was performed by applying the charge plunger technique, which relies on the detection of the charge state-distribution of recoils rather than the detection of the emitted γ rays. This state was a good candidate to test the charge plunger technique as it has a known lifetime and depopulates through a converted transition that competes strongly with γ -ray emission. The lifetime of the 2 1 + state was measured to be 480 ( 10 ) ps , which is consistent with previously reported lifetimes that relied on the standard γ -ray techniques. The charge plunger technique is a complementary approach to lifetime measurements of excited states that depopulate through both γ -ray emission and internal conversion. In cases where it is not possible to detect Doppler-shifted γ rays, for example, in heavy nuclei where internal conversion dominates, it may well be the only feasible lifetime analysis approach.

SummaryThe research laboratories of the modern pharmaceutical companies are of comparatively recent origin and are staffed by scientists from many different disciplines. Long-term research projects ca

Despite recent advances in cancer immunotherapy, no prospectively validated intermediate biomarkers exist to predict response. These biomarkers are highly desirable given modern immunotherapy’s paradoxical pattern of clinical benefit; that is, improvement in overall survival without short-term change in progression. Immunotherapy clinical trials have evaluated biomarkers that may correlate with clinical outcomes. Many of them are performed on peripheral blood to evaluate the systemic response, such as tumor-targeted humoral and cellular immunity, and cytokine responses. Accumulating evidence suggests that immune infiltrates in tumors may suggest evidence for the therapy’s mechanism of action, and have greater potential for providing prognostic and predictive information. In addition, a non-immunologic biomarker, such as tumor growth kinetics, may explain this paradoxical pattern of clinical benefit, and predict survival in patients treated with an immunotherapy. Prospective assessment and validation of these and other intermediate markers would be required to better understand their potential clinical role.