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Introduction Migraine and bipolar disorder (BD) are two chronic and recurrent disorders with a major impact on patient’s quality of life. It is now well known that affective disorders and migraine are often comorbid (Leo et al. Scand J Pain. 2016; 11:136-145). Starting from these observations, we can hypothesis that BD patients with comorbid migraine might have specifical clinical and biological features. Objectives The aim of this study was to estimate the prevalence of migraine in a cohort of French BD patients; determine sociodemographic, clinical, and biological features associated BD-migraine comorbidity. Methods 4348 BD patients from the FACE-BD cohort were included from 2009 to 2022. Sociodemographic and clinical characteristics, lifestyle information, and data on antipsychotic treatment and comorbidities were collected, and a blood sample was drawn. The Structured Clinical Interview for DSM-IV Axis I Disorders was used to confirm the diagnosis of BD. Migraine diagnosis was established according to a clinician-assessed questionnaire. Results 20.1% of individuals with BD had comorbid migraine. Half of these patients received treatment for migraine. Multivariate logistic regression model showed that risk of migraine in women was nearly twice that in men (OR = 1.758; 95% CI, 1.345-2.298). Anxiety disorder, sleep disturbances and childhood trauma were also associated with an increased risk of migraine comorbidity. Patients receiving antipsychotic treatment had less risk of developing migraine than those not receiving those treatment (OR 0.716, 95% CI, 0.554-0.925), independent of other potential confounders. Conclusions The prevalence of migraine in our cohort was lower than those previously reported in other studies. This result might suggest an overestimation of migraine diagnosis in BD patients population studies. However, BD-migraine comorbidity could constitute a subphenotype of bipolar disorder requiring specific treatments. Disclosure of Interest None Declared

Introduction Bipolar Disorder (BD) is a common psychiatric disease. It has been demonstrated a long time ago that bipolar patients are more painful than the healthy subjects. Substance use disorder is a frequent comorbidity in BD, but also in painful patients. The aim of our study was to analyze if bipolar patients with a painful expression have more substance use disorder than bipolar patients without pain. Objectives The aim of our study was to analyze if bipolar patients with a painful expression have more substance use disorder than bipolar patients without pain Methods We included all bipolar patients from the FACE-BD cohort which is a prospective cohort of French outpatients with BD enrolled at the 12 advanced Centers of Expertise in Bipolar Disorder (CEBD). Pain has been evaluated by the “pain item” of the EQ-5D scale and we divided subjects in four categories: “no pain”, “slight pain”, “moderate pain”, “severe or extreme pain”. A multivariate analysis was performed to identify differences between each pain’s groups according to the kind of substance use disorder, psychiatric comorbidities and clinicals data. Results The cohort enrolled 1897 bipolar patients, 970 had no pain (51.1%), 507 had slight pain (26.7%), 298 had moderate pain (15.7%) and 122 had severe or extreme pain (6.4%). We found significant differences according to age, comorbidities and clinicals data with older, more anxious, and more severe patients more represented in the more painful groups. Painful bipolar patients had also more frequently lifetime substance use disorders (alcohol, opioid, sedative, marijuana) and we were able to characterize different profiles in bipolar patients. Conclusions Bipolar patients with a painful expression had more risks to have a lifetime substance use disorder, an anxiety disorder, and a higher score on MADRS. Interestingly, subjects seemed to prefer substances with anxiolytic or antalgic effects during the acute intoxication as alcohol, marijuana, opioid and sedatives. Disclosure of Interest None Declared

Downlink measurement campaigns from the optical downlink terminal OSIRISv1 onboard the LEO satellite Flying Laptop were carried out with the French Observatoire de la Côte d'Azur and with two Optical Ground Stations of the German Aerospace Center. On/off keyed data at 39 Mb/s were modulated on the laser signal, and according telecom reception was performed by the ground stations. The pointing of the laser terminal was achieved by open-loop body pointing of the satellite orientation, with its star sensor as attitude control signal. We report here on the measurements and investigations of the downlink signal and the data transmission.

The future generation of extremely large telescopes will be certainly equipped with wide-field adaptive optics systems. All the components of such adaptive optics systems have to be precisely specified, and most of the technical specifications are related to atmospheric turbulence parameters, particularly the profile of the refractive index structure constant C n 2( h ). The monitor Profiler of Moon Limb (PML) for the extraction of the C n 2( h ) profile with high vertical resolution for nighttime and daytime conditions by the observation of the moon limb or sun edge has been developed and is now routinely exploited at the Calern Observatory on the French Riviera. The PML instrument uses a differential method with two small subapertures through which the moon limb or sun edge are observed, leading to a continuum of double stars that allows a scan of the whole atmosphere with high resolution in altitude. The PML is an autonomous instrument aided by a set of equipment such as an all-sky camera, a small meteorological station, and an automatic system to cover the two subapertures with solar filters to switch from night/moon to day/solar observations. In addition, the PML instrument provides in real time a large characterization of the atmospheric turbulence since it can measure other turbulence parameters, such as the total seeing and the isoplanatic angle.

Optical system performances can be affected by local optical turbulence created by its surrounding environment (telescope dome, clean room, or atmospheric layer). This paper follows a previous one introducing the INdoor TurbulENce SEnsor (INTENSE) instrument for optical turbulence characterization in a local area by exploitation of laser beam angle-of-arrival fluctuations. After a brief summary of the theoretical background, we present in this part results obtained using the INTENSE instrument in various optical integration testing clean rooms and telescope domes, each with specific air behavior conditions.

Optical system performances can be affected by local optical turbulence created by its surrounding environment (telescope dome, clean room, atmospheric surface layer). We present our new instrument INdoor TurbulENce SEnsor (INTENSE) dedicated to this local optical turbulence characterization. INTENSE consists of using several parallel laser beams separated by non-redundant baselines between 0.05 and 2.5 m and measuring the angle of arrival fluctuations from spot displacements on a CCD. After introducing the theoretical background, we give a description of the instrument including a detailed characterization of instrumental noise and, finally, give the first results for the characterization of the turbulence inside clean rooms for optical systems studies.

We realize experimentally an atom-optics quantum-chaotic system, the quasiperiodic kicked rotor, which is equivalent to a 3D disordered system that allows us to demonstrate the Anderson metal-insulator transition. Sensitive measurements of the atomic wave function and the use of finite-size scaling techniques make it possible to extract both the critical parameters and the critical exponent of the transition, the latter being in good agreement with the value obtained in numerical simulations of the 3D Anderson model.

We study the destruction of dynamical localization experimentally observed in an atomic realization of the kicked rotor by a deterministic Hamiltonian perturbation, with a temporal periodicity incommensurate with the principal driving. We show that the destruction is gradual, with well-defined scaling laws for the various classical and quantum parameters, in sharp contrast to predictions based on the analogy with Anderson localization.

Dynamical localization is a localization phenomenon taking place, for example, in the quantum periodically driven kicked rotor. It is due to subtle quantum destructive interferences and is thus of intrinsic quantum origin. It has been shown that deviation from strict periodicity in the driving rapidly destroys dynamical localization. We report experimental results showing that this destruction is partially reversible when the deterministic perturbation that destroyed it is slowly reversed. We also provide an explanation for the partial character of the reversibility.