452 results on '"J. Araujo"'
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2. Functional outcomes of supraglottic squamous cell carcinoma treated by transoral laser microsurgery compared with horizontal supraglottic laryngectomy in patients younger and older than 65 years
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C.M. Chiesa Estomba, F.A. Betances Reinoso, A.I. Lorenzo Lorenzo, J.L. Fariña Conde, J. Araujo Nores, and C. Santidrian Hidalgo
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Otorhinolaryngology ,RF1-547 - Abstract
Il trattamento dei carcinomi sopraglottici rappresenta al momento una problematica controversa. Al momento sono disponibili 5 differenti opzioni di trattamento: la tradizionale laringectomia orizzontale sopraglottica (HSL), la laringectomia sopraglottica con laser CO2 (TLM), lapproccio mediante chirurgia robotica, la radioterapia e la radioterapia in combinazione con la radiochemioterapia. Alcuni studi hanno evidenziato come il rate di complicanze della chirurgia del distretto testa collo aumenti significativamente nei soggetti al di sopra dei 65 anni. Abbiamo pertanto voluto effettuare uno studio retrospettivo che confrontasse i risultati funzionali e il rate di complicanze nei pazienti al di sotto e al di sopra dei 65 anni, affetti da carcinomi squamocellulari sopraglottici T1-T3, sottoposti a laringectomia orizzontale sopraglottica tradizionale (HSL) o a TLM presso un Polo ospedaliero Universitario di terzo livello. Il gruppo di pazienti al di sopra dei 65 anni sottoposto a TLM ha mostrato differenze statisticamente significative per quanto riguarda il rate di polmonite ab ingestis (p = 0.026), tempo medio necessario al decannulamento (p = 0.001) e tempo medio di ricovero ospedaliero (p = 0.007) tutti risultati più lunghi rispetto a quelli osservati nei pazienti al di sotto dei 65 anni. Per quanto riguarda la chirurgia open, abbiamo rilevato una differenza statisticamente significativa solo per il tempo medio necessario per il decannulamento (p = 0.001) risultato essere più lungo nel gruppo di pazienti più giovani di 65 anni. In accordo coi nostri risultati sia la TLM che lapproccio open rappresentano opzioni sicure nei pazienti al di sopra dei 65 anni, ma in cosiderazione dellaumentato rischio di polmonite ab ingestis è mandatoria un adeguata valutazione della funzionalità polmonare preoperatoria, in particolare nei pazienti trattati con TLM. Nei pazienti al di sopra dei 65 anni inoltre la TLM rispetto allapproccio open riduce il rate di tracheostomie postoperatorie, il tempo medio necessario al decannulamento e il tempo medio di ricovero. Tuttavia non è stata rilevata alcuna differenza significativa in termini di rate di polmonite ab ingestis, disfagia o tempo medio di utilizzo del sondino naso gastrico.
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- 2016
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3. MAGNITUDES DENDROMÉTRICAS DE CUATRO POBLACIONES DE ALGARROBO BLANCO (PROSOPIS ALBA GRISEB.) DE DIFERENTES EDADES
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A. BENDER, J. ARAUJO, M. PERRETA, and J. MOGLIA
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Prosopis alba ,magnitudes dendrométricas ,relaciones alométricas ,incremento anual. ,Agriculture ,Agriculture (General) ,S1-972 - Published
- 2016
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4. Efecto de la ozonoterapia sobre el intervalo parto-celo y la fertilidad en vacas lecheras
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J. Araujo, J. Argudo, J. Narváez, and D. Galarza
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Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
INTRODUCCIÓN En la vaca lechera la atención médica del puerperio es fundamental en los programas de manejo reproductivo. Durante este periodo se diagnostican y tratan patologías del útero con el propósito de acortar el periodo de espera voluntaria (Djuricic et al., 2012a). La ozonoterapia como medicina alternativa, es usada en tratamientos de mastitis y otros procesos infecciosos reproductivos intrauterinos (endometritis, metritis, etc.). El Ozono tiene propiedades desinfectantes, antivirales, y antibacterianas sistémicas, mejora el metabolismo celular, aumentando el número de glóbulos rojos, oxigenando mejor la sangre y aumentando la presión arterial, de esta manera la sangre pasa más rápido por las partes afectadas ejerciendo así un efecto positivo sobre los tejidos (Djuricic et al., 2012b). El objetivo del trabajo fue evaluar el efecto de la ozonoterapia sobre el intervalo parto-celo y la fertilidad de las vacas.
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- 2015
5. Semi-proper orientations of dense graphs.
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J. Araujo, Frédéric Havet, Cláudia Linhares Sales, Nicolas Nisse, and Karol Suchan
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- 2023
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6. Adults with Congenital Heart Disease in South America: Where Are We Today and What Will the Immediate Future Look Like?
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John J, Araujo, primary
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- 2024
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7. Numerical study of treatment chambers for single and multi‐stage pulsed electric field systems
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Eduardo J. Araujo, Ivan J. S. Lopes, and Jaime A. Ramirez
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Numerical analysis ,Industrial processes ,Products and commodities ,Beverage industry ,Biotechnology industry ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
Abstract Pulsed electric field (PEF) systems should be designed to be microbiologically and energy efficient for industrial applications applied to treatment of different types of liquid foods. A thorough numerical model for the design of PEF systems is presented. It takes into account two combined approaches, a field evaluation based on an electric‐thermal‐fluid dynamic analysis and a design of numerical experiment considering as variables the applied high voltage and the internal electrode radius of a coaxial geometry. Then, the survival ratio and the specific energy are solved as conflicting objectives for the PEF design, using the treatment time and pulse frequency from the coupled analysis. The formulation is applied for grape and orange juices with E. coli for single and multiple stages systems. The simulations with multiple stages for the grape juice showed that it is possible to reach a microbial inactivation of 3.1 (log10 scale of survival rate) with a specific energy of about 450kJ/kg lower in relation to a two stage system. It means an energy reduction of 92, 421kJ/h for a treatment system with a capacity of 163 L/h.
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- 2021
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8. Transfer of quantum states through a disordered channel with exponentially decaying couplings.
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F. J. Araujo Filho, R. F. Dutra, I. F. F. dos Santos, Marcelo L. Lyra, Guilherme M. A. Almeida, and Francisco A. B. F. de Moura
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- 2023
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9. mStatGraph: Exploration and statistical treatment software to process, compute and validate oceanographic data.
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Humberto L. Varona, C. Noriega, J. Araujo, Simone Maria de Albuquerque Lira, Moacyr Araujo, and F. Hernandez
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- 2023
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10. Corrigendum to "mStatGraph: Exploration and statistical treatment software to process, compute and validate oceanographic data" [Softw. Impacts 17 (2023) 100571].
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Humberto L. Varona, C. Noriega, J. Araujo, Simone Maria de Albuquerque Lira, Moacyr Araujo, and F. Hernandez
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- 2023
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11. DSCompare: Unleashing the potential of ocean and atmospheric data with a comparative analysis software.
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Humberto L. Varona, T. A. Capuano, C. Noriega, J. Araujo, Moacyr Araujo, and F. Hernandez
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- 2023
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12. On the theoretical analysis of box-constrained adaptive filters.
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Leilson J. Araujo, Vítor H. Nascimento, and Yuriy V. Zakharov
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- 2017
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13. Coordinated crosstalk between microtubules and actin by a spectraplakin regulates lumen formation and branching
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Delia Ricolo and Sofia J Araujo
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lumen ,subcellular ,branching ,Drosophila ,short-stop ,tau ,Medicine ,Science ,Biology (General) ,QH301-705.5 - Abstract
Subcellular lumen formation by single-cells involves complex cytoskeletal remodelling. We have previously shown that centrosomes are key players in the initiation of subcellular lumen formation in Drosophila melanogaster, but not much is known on the what leads to the growth of these subcellular luminal branches or makes them progress through a particular trajectory within the cytoplasm. Here, we have identified that the spectraplakin Short-stop (Shot) promotes the crosstalk between MTs and actin, which leads to the extension and guidance of the subcellular lumen within the tracheal terminal cell (TC) cytoplasm. Shot is enriched in cells undergoing the initial steps of subcellular branching as a direct response to FGF signalling. An excess of Shot induces ectopic acentrosomal luminal branching points in the embryonic and larval tracheal TC leading to cells with extra-subcellular lumina. These data provide the first evidence for a role for spectraplakins in single-cell lumen formation and branching.
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- 2020
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14. Molecular characterization of the adsorptive properties of extended graphene towards polyaromatic compounds of environmental interest: chrysene, benzo[a]anthracene, benzo[a]pyrene and benzo[b]fluoranthene.
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Vianeis de J. Araujo, Nestor Cubillán, Oscar Lindo-Oñate, and Olga Castellano
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- 2017
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15. OBTENCIÓN DE RECUBRIMIENTOS COMPUESTOS DE HfN/HfO2 DUROS Y TRANSPARENTES POR SPUTTERING Y TRATAMIENTOS TÉRMICOS
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Leandro García, Daniel de J. Araujo, Ma. Guadalupe Garnica, Luis Zamora, Leonardo Hernández, and Julián Hernández
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Engineering (General). Civil engineering (General) ,TA1-2040 ,Science (General) ,Q1-390 - Abstract
Se sintetizaron recubrimientos de HfN sobre vidrio Corning por la técnica de erosión catódica. Se realizaron tratamientos térmicos post-depósito a 300 °C, 400 °C y 500 °C para obtener recubrimientos compuestos de HfN/HfO2, y analizar cambios en la dureza y transmitancia en función de su microestructura. Los recubrimientos se caracterizaron por DRX, MEB-EC, EED, dureza Vickers y UV-vis. DRX mostró que los tratamientos térmicos cambian las fases en los recubrimientos, logrando obtener el recubrimiento compuesto de HfN/HfO2 para los tratamientos térmicos de 400 °C y 500 °C. Por MEB-EC se corroboraron los resultados de DRX mostrando cambios morfológicos con el aumento de la temperatura. La dureza Vickers y el porcentaje de transmitancia aumentaron conforme la temperatura aumentó, logrando alcanzar valores máximos de 22 GPa y 71 %, respectivamente. La tenacidad a la fractura disminuye con el aumento de temperatura, pero el band gap se mantiene constante en 4.17 eV.
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- 2017
16. Single-cell immune profiling reveals long-term changes in myeloid cells and identifies a novel subset of CD9+ monocytes associated with COVID-19 hospitalization
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William J Pandori, Lindsey E Padgett, Ahmad Alimadadi, Norma A Gutierrez, Daniel J Araujo, Christine J Huh, Claire E Olingy, Huy Q Dinh, Runpei Wu, Pandurangan Vijayanand, Serena J Chee, Christian H Ottensmeier, and Catherine C Hedrick
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Immunology ,Immunology and Allergy ,Cell Biology - Abstract
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in severe immune dysfunction, hospitalization, and death. Many patients also develop long-COVID-19, experiencing symptoms months after infection. Although significant progress has been made in understanding the immune response to acute SARS-CoV-2 infection, gaps remain in our knowledge of how innate immunity influences disease kinetics and severity. We hypothesized that cytometry by time-of-flight analysis of PBMCs from healthy and infected subjects would identify novel cell surface markers and innate immune cell subsets associated with COVID-19 severity. In this pursuit, we identified monocyte and dendritic cell subsets that changed in frequency during acute SARS-CoV-2 infection and correlated with clinical parameters of disease severity. Subsets of nonclassical monocytes decreased in frequency in hospitalized subjects, yet increased in the most severe patients and positively correlated with clinical values associated with worse disease severity. CD9, CD163, PDL1, and PDL2 expression significantly increased in hospitalized subjects, and CD9 and 6-Sulfo LacNac emerged as the markers that best distinguished monocyte subsets amongst all subjects. CD9+ monocytes remained elevated, whereas nonclassical monocytes remained decreased, in the blood of hospitalized subjects at 3–4 months postinfection. Finally, we found that CD9+ monocytes functionally released more IL-8 and MCP-1 after LPS stimulation. This study identifies new monocyte subsets present in the blood of COVID-19 patients that correlate with disease severity, and links CD9+ monocytes to COVID-19 progression.
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- 2022
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17. Spin polarization of carriers in resonant tunneling devices containing InAs self-assembled quantum dots
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Nobrega, J. Araújo e, Gordo, V. Orsi, Galeti, H.V.A., Gobato, Y. Galvão, Brasil, M.J.S.P., Taylor, D., Orlita, M., and Henini, M.
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- 2015
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18. Editor's evaluation: Hypoxia-induced tracheal elasticity in vector beetle facilitates the loading of pinewood nematode
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Sofia J Araujo
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- 2023
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19. Position Statement for the Development of Adult Congenital Heart Disease Units in Latin America and the Caribbean: Recommendations by the Adult Congenital Heart Disease Chapter and Pediatric Cardiology Council of the Interamerican Society of Cardiology (IASC). Endorsed by the International Society of Adult Congenital Heart Disease (ISACHD)
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John J. Araujo, Carla P. Rodríguez-Monserrate, Amalia Elizari, Lucelli Yáñez-Gutiérrez, Mariela Mouratian, Fernando Amaral, Manuel Huertas-Quiñonez, Mónica Rosario, Mauricio O'Connell, Oscar N. Aguirre-Zurita, Carlos Fernández, Marcelo Callau-Briceño, María M. Lorente- Coppola, and Nancy Garay
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General Medicine - Published
- 2023
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20. Effect of the incorporation of carbon in the structure of TiO2 anodized with HCl on the mechanical and tribological properties
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S. Hernández Montiel, L. García González, D. J. Araujo Pérez, A. López Velázquez, L. Zamora Peredo, A. Báez Rodríguez, J. Morales Hernández, and J. Hernández Torres
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Mechanics of Materials ,Mechanical Engineering ,General Materials Science ,Condensed Matter Physics - Published
- 2021
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21. Cameralismo: un antecedente más en la evolución de la administración como ciencia
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Alice J. Araujo Lobo
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administración ,cameralismo ,ciencias cameralisticas ,gerencialismo ,Management. Industrial management ,HD28-70 ,Business ,HF5001-6182 - Abstract
Generalmente, el estudio de la administración como ciencia parte de los postulados de la administración científica desarrollada por Frederick Taylor. Sin embargo, de acuerdo a la investigación documental realizada, desde 1727 en las universidades alemanas se enseñaban las ciencias cameralisticas, en las cuales se hallan raíces tanto de la economía como de la administración. Por tanto, es oportuno profundizar en el estudio del cameralismo, bien sea para darle un nueva orientación a la carrera de administración, crear una carrera nueva, o modificar su pensum de estudio con el propósito de hacer de la administración una ciencia más holística e integradora de conocimientos sobre economía política, macroeconomía y administración, distinta del gerencialismo o la business administration y, permitir al profesional de la administración desempeñarse con mayor eficiencia en organizaciones públicas o privadas.
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- 2015
22. Local People Standings on Existing Farm Animal Welfare Legislation in the BRIC Countries and the USA. Comparison with Western European Legislation
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F. Mata, J. Araujo, L. Soares, and J. L. Cerqueira
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General Veterinary ,Animal Science and Zoology - Abstract
This study explored the demand for improved farm animal welfare (FAW) legislation in the BRIC countries and the USA. Results are discussed in comparison to Europe. Interviewees ranked their willingness to support or oppose introduction of more FAW-friendly laws in their country. A multinomial logistic regression was fit to the data (p 0.001), with the parameters "country × gender" (p 0.001) and "country × age" (p 0.001) found significant. Americans, Russian women, and older Brazilian men are very supportive. The age effect is also felt in India, where older people are more supportive. Chinese, American men, and younger Indians are less supportive. Russian males are the group that oppose the most, followed by younger Brazilians and Indians. The law and its application vary a lot between countries. Nevertheless, the societal willingness to improve FAW legislation is high in all countries. The willingness is higher in Europe. The different cultural backgrounds, the socio-economic factors, and the social, economic, and environmental sustainability are enough reasons to create barriers to policy harmonization in the global trade of farm animal products.
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- 2022
23. Modeling the evolutionary history of nonclassical monocytes in mammals
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Daniel J. Araujo, Diego Fernandez, Ahmad Alimadadi, Axel Zagal-Norman, and Catherine C. Hedrick
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The immune system has experienced major changes in both its organization and function during the evolution of tetrapod animals. Still, the ancestry of specific cell types and the historical relationships between modern immune cells has received little attention. While all tetrapods possess mononuclear blood cells and monocytes, vasculature-patrolling nonclassical monocytes (CD16+CD14-in humans, Ly6C-in mice) have so far only been described in mammals. The question of whether nonclassical monocytes are specific to the mammalian lineage has not been answered. Cell types can be described as traits that persist via the inheritance of core regulatory complexes of transcription factors. We utilized transcriptional network analyses on a human monocyte single-cell RNA-sequencing dataset to highlight the core regulatory complex associated with nonclassical monocyte production (nCoRC). We then applied BLAST-based analyses to quantify the conservation of human nCoRC members amongst mammals and nonmammals. We determined that the average sequence similarity of nCoRC members is highest amongst mammals and that such conservation is not observed in non-mammalian tetrapods. We also discovered that this sequence similarity is specifically driven by boreoeutherian placental mammals. Finally, we found the receptor proteins upstream of nonclassical monocyte assembly are also more homologous in mammals than non-mammals. This work provides an evolutionary model in which the capacity for nonclassical monocyte production is unique to the mammalian lineage.
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- 2022
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24. Atherosclerosis Impairs Naive CD4 T-Cell Responses via Disruption of Glycolysis
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Angela M. Taylor, Chantel McSkimming, Huy Q. Dinh, Lindsey E. Padgett, Catherine C. Hedrick, Daniel J. Araujo, Dalia E. Gaddis, Coleen A. McNamara, Runpei Wu, and Anh T. Nguyen
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CD4-Positive T-Lymphocytes ,Male ,0301 basic medicine ,medicine.medical_specialty ,Apolipoprotein B ,Mice, Knockout, ApoE ,Glucose uptake ,030204 cardiovascular system & hematology ,Lymphocyte Activation ,Article ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Internal medicine ,medicine ,Animals ,Humans ,Glycolysis ,Gene ,Cells, Cultured ,Aged ,Cell Proliferation ,biology ,business.industry ,Fatty Acids ,Metabolism ,Middle Aged ,Atherosclerosis ,Plaque, Atherosclerotic ,CD4 Lymphocyte Count ,Mice, Inbred C57BL ,Disease Models, Animal ,Metabolic pathway ,Phenotype ,030104 developmental biology ,Endocrinology ,Gene Expression Regulation ,Diet, Western ,Knockout mouse ,biology.protein ,Female ,Cardiology and Cardiovascular Medicine ,business ,Oxidation-Reduction - Abstract
Objective: CD4 T cells are important regulators of atherosclerotic progression. The metabolic profile of CD4 T cells controls their signaling and function, but how atherosclerosis affects T-cell metabolism is unknown. Here, we sought to determine the impact of atherosclerosis on CD4 T-cell metabolism and the contribution of such metabolic alterations to atheroprogression. Approach and Results: Using PCR arrays, we profiled the expression of metabolism genes in CD4 T cells from atherosclerotic apolipoprotein-E knockout mice fed a Western diet. These cells exhibited dysregulated expression of genes critically involved in glycolysis and fatty acid degradation, compared with those from animals fed a standard laboratory diet. We examined how T-cell metabolism was changed in either Western diet–fed apolipoprotein-E knockout mice or samples from patients with cardiovascular disease by measuring glucose uptake, activation, and proliferation in CD4 T cells. We found that naive CD4 T cells from Western diet–fed apolipoprotein-E knockout mice failed to uptake glucose and displayed impaired proliferation and activation, compared with CD4 T cells from standard laboratory diet–fed animals. Similarly, we observed that naive CD4 T-cell frequencies were reduced in the circulation of human subjects with high cardiovascular disease compared with low cardiovascular disease. Naive T cells from high cardiovascular disease subjects also showed reduced proliferative capacity. Conclusions: These results highlight the dysfunction that occurs in CD4 T-cell metabolism and immune responses during atherosclerosis. Targeting metabolic pathways within naive CD4 T cells could thus yield novel therapeutic approaches for improving CD4 T-cell responses against atheroprogression.
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- 2021
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25. Tunable Band-Edge Potentials and Charge Storage in Colloidal Tin-Doped Indium Oxide (ITO) Nanocrystals
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Hongbin Liu, Jose J. Araujo, Daniel R. Gamelin, Anna Merkulova, Carl K. Brozek, and Xiaosong Li
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Materials science ,Dopant ,Fermi level ,Doping ,General Engineering ,General Physics and Astronomy ,chemistry.chemical_element ,Delocalized electron ,symbols.namesake ,chemistry ,Chemical physics ,symbols ,General Materials Science ,Charge carrier ,Surface charge ,Indium ,Localized surface plasmon - Abstract
Degenerately doped metal-oxide nanocrystals (NCs) show localized surface plasmon resonances (LSPRs) that are tunable via their tunable excess charge-carrier densities. Modulation of excess charge carriers has also been used to control magnetism in colloidal doped metal-oxide NCs. The addition of excess delocalized conduction-band (CB) electrons can be achieved through aliovalent doping or by postsynthetic techniques such as electrochemistry or photodoping. Here, we examine the influence of charge-compensating aliovalent dopants on the potentials of excess CB electrons in free-standing colloidal degenerately doped oxide NCs, both experimentally and through modeling. Taking Sn4+:In2O3 (ITO) NCs as a model system, we use spectroelectrochemical techniques to examine differences between aliovalent doping and photodoping. We demonstrate that whereas photodoping introduces excess CB electrons by raising the Fermi level relative to the CB edge, aliovalent impurity substitution introduces excess CB electrons by stabilizing the CB edge relative to an externally defined Fermi level. Significant differences are thus observed electrochemically between spectroscopically similar delocalized CB electrons compensated by aliovalent dopants and those compensated by surface cations (e.g., protons) during photodoping. Theoretical modeling illustrates the very different potentials that arise from charge compensation via aliovalent substitution and surface charge compensation. Spectroelectrochemical titrations allow the ITO NC band-edge stabilization as a function of Sn4+ doping to be quantified. Extremely large capacitances are observed in both In2O3 and ITO NCs, making these NCs attractive for reversible charge-storage applications.
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- 2021
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26. Editor's evaluation: Integration of mouse ovary morphogenesis with developmental dynamics of the oviduct, ovarian ligaments, and rete ovarii
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Sofia J Araujo
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- 2022
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27. Metabolite signature and differential expression of genes in Washington Navel oranges (
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Christopher J, McNeil, Karla J, Araujo, Kris, Godfrey, and Carolyn M, Slupsky
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- 2022
28. Numerical study of treatment chambers for single and multi‐stage pulsed electric field systems
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I.J.S. Lopes, Eduardo J. Araujo, and Jaime A. Ramírez
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Multi stage ,Materials science ,Electric field ,Mechanical engineering ,Electrical engineering. Electronics. Nuclear engineering ,Electrical and Electronic Engineering ,Atomic and Molecular Physics, and Optics ,TK1-9971 - Abstract
Pulsed electric field (PEF) systems should be designed to be microbiologically and energy efficient for industrial applications applied to treatment of different types of liquid foods. A thorough numerical model for the design of PEF systems is presented. It takes into account two combined approaches, a field evaluation based on an electric‐thermal‐fluid dynamic analysis and a design of numerical experiment considering as variables the applied high voltage and the internal electrode radius of a coaxial geometry. Then, the survival ratio and the specific energy are solved as conflicting objectives for the PEF design, using the treatment time and pulse frequency from the coupled analysis. The formulation is applied for grape and orange juices with E. coli for single and multiple stages systems. The simulations with multiple stages for the grape juice showed that it is possible to reach a microbial inactivation of 3.1 (log10 scale of survival rate) with a specific energy of about 450kJ/kg lower in relation to a two stage system. It means an energy reduction of 92, 421kJ/h for a treatment system with a capacity of 163 L/h.
- Published
- 2021
29. COVID-19 in Adults With Congenital Heart Disease
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Jamil Aboulhosn, Francisco J. Ruperti-Repilado, Ian Lindsay, Anitha S. John, Heather L. Bartlett, Harsimran Singh, Stacy D. Fisher, Timothy B. Cotts, Elizabeth Yeung, Matthew R. Carazo, Laith Alshawabkeh, Kristi Ryan, Jong M. Ko, David Gregg, Arsha Karbassi, Jennifer R. Maldonado, Lauren Andrade, Ari Cedars, Prashob Porayette, Shailendra Upadhyay, Payam Dehghani, John J. Araujo, Fred H. Rodriguez, Francisca Arancibia Galilea, Jonathan W. Cramer, Adrienne H. Kovacs, Marlon Rosenbaum, Benjamin P. Frischhertz, Eric V. Krieger, Sébastien Hascoët, Scott Cohen, Dan G. Halpern, George Giannakoulas, Hassan Almeneisi, Jeremy Nicolarsen, Christopher R. Broda, Craig S. Broberg, Arvind K. Hoskoppal, Daniel Tobler, Jasmine Grewal, Poyee P. Tung, Carla P. Rodriguez-Monserrate, Anisa Chaudhry, George K. Lui, Flavia Fusco, Khalid Al Najashi, Jodi L. Feinberg, Scott E. Klewer, Soraya Sadeghi, Berto J. Bouma, Markus Schwerzmann, Berardo Sarubbi, Judith Bouchardy, Amiram Nir, Paolo Ferrero, Matthias Greutmann, Salwa M. Gendi, Benjamin Hendrickson, Efren Martinez-Quintana, Matthew J. Lewis, Georges Ephrem, Stephen Cook, Rose O. Tompkins, Magalie Ladouceur, Alexandra Frogoudaki, Fernando Baraona, Pablo Meras, Shabnam Mohammadzadeh, Rocio Garcia-Orta, Cardiology, ACS - Heart failure & arrhythmias, and ACS - Pulmonary hypertension & thrombosis
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Male ,Pediatrics ,Heart disease ,coronavirus ,Comorbidity ,030204 cardiovascular system & hematology ,Global Health ,law.invention ,0302 clinical medicine ,PCR, polymerase chain reaction ,COVID-19 Testing ,law ,Risk Factors ,030212 general & internal medicine ,610 Medicine & health ,Original Investigation ,education.field_of_study ,COVID-19, coronavirus disease-2019 ,eGFR, estimated glomerular filtration rate ,Intensive care unit ,ICU, intensive care unit ,Hospitalization ,Causality ,Cohort ,Female ,PAH, pulmonary arterial hypertension ,Symptom Assessment ,Cardiology and Cardiovascular Medicine ,hospitalization ,Adult ,Heart Defects, Congenital ,medicine.medical_specialty ,Hypertension, Pulmonary ,Population ,Article ,03 medical and health sciences ,Diabetes mellitus ,medicine ,adult congenital heart disease ,Humans ,Cardiac Surgical Procedures ,Mortality ,education ,Cyanosis ,business.industry ,SARS-CoV-2 ,Patient Acuity ,COVID-19 ,medicine.disease ,Pulmonary hypertension ,CI, confidence interval ,OR, odds ratio ,CHD, congenital heart disease ,Heart failure ,business - Abstract
Background Adults with congenital heart disease (CHD) have been considered potentially high risk for novel coronavirus disease-19 (COVID-19) mortality or other complications. Objectives This study sought to define the impact of COVID-19 in adults with CHD and to identify risk factors associated with adverse outcomes. Methods Adults (age 18 years or older) with CHD and with confirmed or clinically suspected COVID-19 were included from CHD centers worldwide. Data collection included anatomic diagnosis and subsequent interventions, comorbidities, medications, echocardiographic findings, presenting symptoms, course of illness, and outcomes. Predictors of death or severe infection were determined. Results From 58 adult CHD centers, the study included 1,044 infected patients (age: 35.1 ± 13.0 years; range 18 to 86 years; 51% women), 87% of whom had laboratory-confirmed coronavirus infection. The cohort included 118 (11%) patients with single ventricle and/or Fontan physiology, 87 (8%) patients with cyanosis, and 73 (7%) patients with pulmonary hypertension. There were 24 COVID-related deaths (case/fatality: 2.3%; 95% confidence interval: 1.4% to 3.2%). Factors associated with death included male sex, diabetes, cyanosis, pulmonary hypertension, renal insufficiency, and previous hospital admission for heart failure. Worse physiological stage was associated with mortality (p = 0.001), whereas anatomic complexity or defect group were not. Conclusions COVID-19 mortality in adults with CHD is commensurate with the general population. The most vulnerable patients are those with worse physiological stage, such as cyanosis and pulmonary hypertension, whereas anatomic complexity does not appear to predict infection severity., Central Illustration
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- 2021
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30. Uma Estratégia de Avaliação de um Code Puzzle Game
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Antônio Henrique P. S. P. Machado and Luis Gustavo J. Araujo
- Abstract
Avaliações de jogos educacionais comumente utilizam frameworks de avaliação como o E-GameFlow. Estes frameworks de modo isolado não dão conta das necessidades do processo de design de games. Nesse sentido, este resumo visa apresentar uma estratégia de Avaliação de um Code Puzzle Game por meio de um case do jogo CodeBô, apresentando formas de captura de dados, visualização do progresso, cálculo de desempenho e triangulação dos dados quantitativos e qualitativos.Link para o vídeo da apresentação: https://youtu.be/tdh5Gc3NE-I
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- 2022
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31. CD33 Expression on Peripheral Blood Monocytes Predicts Efficacy of Anti-PD-1 Immunotherapy Against Non-Small Cell Lung Cancer
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Claire, Olingy, Ahmad, Alimadadi, Daniel J, Araujo, David, Barry, Norma A, Gutierrez, Max Hardy, Werbin, Edurne, Arriola, Sandip Pravin, Patel, Christian H, Ottensmeier, Huy Q, Dinh, and Catherine C, Hedrick
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Lung Neoplasms ,Non-small cell lung cancer ,Carcinoma, Non-Small-Cell Lung ,Sialic Acid Binding Ig-like Lectin 3 ,Immunology ,Leukocytes, Mononuclear ,Humans ,Immunology and Allergy ,Immunotherapy ,CD33 ,Immunosuppression ,Monocytes - Abstract
Non-small cell lung carcinoma (NSCLC) is the leading cause of cancer-related deaths globally. Immune checkpoint blockade (ICB) has transformed cancer medicine, with anti-programmed cell death protein 1 (anti-PD-1) therapy now well-utilized for treating NSCLC. Still, not all patients with NSCLC respond positively to anti-PD-1 therapy, and some patients acquire resistance to treatment. There remains an urgent need to find markers predictive of anti-PD-1 responsiveness. To this end, we performed mass cytometry on peripheral blood mononuclear cells from 26 patients with NSCLC during anti-PD-1 treatment. Patients who responded to anti-PD-1 ICB displayed significantly higher levels of antigen-presenting myeloid cells, including CD9+ nonclassical monocytes, and CD33hi classical monocytes. Using matched pre-post treatment samples, we found that the baseline pre-treatment frequencies of CD33hi monocytes predicted patient responsiveness to anti-PD-1 therapy. Moreover, some of these classical and nonclassical monocyte subsets were associated with reduced immunosuppression by T regulatory (CD4+FOXP3+CD25+) cells in the same patients. Our use of machine learning corroborated the association of specific monocyte markers with responsiveness to ICB. Our work provides a high-dimensional profile of monocytes in NSCLC and links CD33 expression on monocytes with anti-PD-1 effectiveness in patients with NSCLC.
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- 2022
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32. Theoretical study of the linear and nonlinear optical properties of the Photosensibilizer molecules: Photofrin and foscan in gas phase.
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Vianeis de J. Araujo, Humberto Soscún, and Leonardo J. Rodríguez
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- 2009
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33. Frecuencia de depresión e incontinencia urinaria en pacientes de una institución de alta complejidad en Callao, Perú
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Jhony A. De La Cruz-Vargas, J. Antonio Grandez-Urbina, Edgar Joel Ancajima-More, Rafael Pichardo-Rodriguez, William J. Araujo-Banchon, and María Alejandra Paz-Caldas
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Gynecology ,medicine.medical_specialty ,Mood ,business.industry ,medicine ,Urinary incontinence ,medicine.symptom ,business ,Depressive symptoms ,Depression (differential diagnoses) - Abstract
Introducción: El objetivo fue explorar la frecuencia y asociación entre la presencia de síntomas depresivos con la existencia de síntomas sugestivos de incontinencia urinaria en un grupo de mujeres atendidas en un hospital público del Perú. Material y Métodos: Estudio transversal realizado en mujeres con Seguro Integral de Salud que acudieron al consultorio de ginecología del hospital público de alta complejidad Hospital Nacional Daniel Alcides Carrión durante noviembre y diciembre del 2018. Se calculó una muestra con Epidat versión 3.1 y se seleccionó a las participantes por conveniencia. Las principales variables de interés fueron incontinencia urinaria y depresión, ambas medidas mediante instrumentos de medición validados: ICIQ-SF y escala de autoevaluación para la depresión de Zung, respectivamente. Para explorar la asociación se usó exacta de Fisher y Kruskall-Wallis. Resultados: Se estudió a 186 mujeres con edades entre 40 y 60 años. Un total de 176 mujeres (94,6 %) se definieron como incontinentes y 183 con depresión (98,4 %). No se encontró asociación entre los síntomas depresivos con los síntomas sugestivos de incontinencia urinaria (p>0,05), pero sí en el grado de síntomas depresivos con el puntaje de incontinencia (p=0,0001). Conclusiones: Una proporción considerable de mujeres padece de síntomas depresivos y de incontinencia urinaria. Por otra para, parece existir una posible asociación entre los puntajes de incontinencia urinaria y la severidad de los síntomas depresivos. Se requieren más estudios que exploren esta posible asociación para dilucidar el impacto potencial que la incontinencia urinaria posee sobre el estado anímico de las mujeres en Perú.
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- 2020
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34. Frontline Science: Kindlin-3 is essential for patrolling and phagocytosis functions of nonclassical monocytes during metastatic cancer surveillance
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Daniel J. Araujo, Sara McArdle, Huy Q. Dinh, Catherine C. Hedrick, Richard N. Hanna, Klaus Ley, Sophia Reynolds, Robert Tacke, Yanfang Peipei Zhu, Runpei Wu, and Paola Marcovecchio
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0301 basic medicine ,Lung ,Endothelium ,Phagocytosis ,Immunology ,Integrin ,Cell Biology ,Biology ,Metastatic tumor ,medicine.disease ,Metastasis ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,In vivo ,030220 oncology & carcinogenesis ,medicine ,Cancer research ,biology.protein ,Immunology and Allergy ,Homeostasis - Abstract
Nonclassical monocytes maintain vascular homeostasis by patrolling the vascular endothelium, responding to inflammatory signals, and scavenging cellular debris. Nonclassical monocytes also prevent metastatic tumor cells from seeding new tissues, but whether the patrolling function of nonclassical monocytes is required for this process is unknown. To answer this question, we utilized an inducible-knockout mouse that exhibits loss of the integrin-adaptor protein Kindlin-3 specifically in nonclassical monocytes. We show that Kindlin-3-deficient nonclassical monocytes are unable to patrol the vascular endothelium in either the lungs or periphery. We also find that Kindlin-3-deficient nonclassical monocytes cannot firmly adhere to, and instead “slip” along, the vascular endothelium. Loss of patrolling activity by nonclassical monocytes was phenocopied by ablation of LFA-1, an integrin-binding partner of Kindlin-3. When B16F10 murine melanoma tumor cells were introduced into Kindlin-3-deficient mice, nonclassical monocytes showed defective patrolling towards tumor cells and failure to ingest tumor particles in vivo. Consequently, we observed a significant, 4-fold increase in lung tumor metastases in mice possessing Kindlin-3-deficient nonclassical monocytes. Thus, we conclude that the patrolling function of nonclassical monocytes is mediated by Kindlin-3 and essential for these cells to maintain vascular endothelial homeostasis and prevent tumor metastasis to the lung.
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- 2020
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35. Linfoma de Burkitt de la calota craneana: a propósito de un caso
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William J. Araujo-Banchon and Carmen Rosa Cerron-Vela
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Gynecology ,perú ,medicine.medical_specialty ,lcsh:R5-920 ,business.industry ,lcsh:R ,linfoma no hodgkin ,lcsh:Medicine ,General Medicine ,medicine.disease ,Lymphoma ,medicine ,cráneo ,business ,lcsh:Medicine (General) ,Burkitt's lymphoma - Abstract
Introducción: El linfoma de Burkitt es un linfoma no Hodgkin de células B cuya ubicación craneal es extremadamente rara. Caso clínico: Se describe el caso de un hombre peruano de 35 años con una tumoración craneal parietal izquierda de crecimiento progresivo. Para la confirmación diagnóstica de linfoma de Burkitt se realizó una biopsia con inmunohistoquímica. Se inició tratamiento ambulatorio de primera línea con CODOX-M/IVAC, sin embargo, deja de acudir a su tratamiento por 2 meses. Retorna, se le evidencia progresión de la enfermedad y se le trata con rituximab, ifosfamida carboplatino y etopósido. No responde de forma satisfactoria y fallece. Conclusiones: El Linfoma de Burkitt es un tumor muy agresivo que si no es tratado oportunamente presenta alta mortalidad, tal como ocurrió con el paciente del caso.
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- 2020
36. Enzymatic Hydrolysis of Fish Waste as an Alternative to Produce High Value-Added Products
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Costas N. Costa, M. C. Márquez, P. Sica, and J. Araujo
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0106 biological sciences ,Environmental Engineering ,Renewable Energy, Sustainability and the Environment ,Chemistry ,020209 energy ,Batch reactor ,Substrate (chemistry) ,02 engineering and technology ,Raw material ,Fish oil ,Pulp and paper industry ,01 natural sciences ,Hydrolysate ,Hydrolysis ,010608 biotechnology ,Enzymatic hydrolysis ,0202 electrical engineering, electronic engineering, information engineering ,Value added ,Waste Management and Disposal - Abstract
Fish waste was studied as a raw material for the simultaneous production of protein hydrolysates, collagen and fish oil. Enzymatic hydrolysis was selected for recovering these by-products with high value-added. Alcalase 2.4 L was used to hydrolyze fish waste in a batch reactor under controlled conditions (180 min, 50 °C and pH 8). The influence of hydrolysis degree on by-products recovery was analyzed for different enzyme and substrate concentrations. Results suggested that the enzyme/substrate ratio was the main factor controlling the hydrolysis rate. Linear relationships were found between the degree of hydrolysis and the amount of each of the obtained by-products. From these relationships, the amounts of by-products with high added value can be predicted by only knowing the degree of hydrolysis reached. In optimal conditions (DH = 25%), 430 g of protein hydrolysate, 10 g of collagen and 350 g of oil could be obtained from 1000 g of fish waste. The use of fish waste as raw material for by-product fabrication resulted in a 79% reduction of waste disposed to landfill. Therefore, this study shows the enzymatic hydrolysis of fish waste as a feasible solution to obtain high value-added products and an alternative to landfilling disposal.
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- 2020
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37. Evaluation of the effectiveness of the OptiMAL-IT™ rapid test in the follow up of patients diagnosed with malaria in the Peruvian Amazon
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William J. Araujo-Banchón, Nancy Arróspide, and Hernán Sanabria
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Gynecology ,efectividad ,medicine.medical_specialty ,Plasmodium ,malaria/diagnóstico ,biology ,business.industry ,Plasmodium vivax ,Diagnostic test ,effectiveness ,Plasmodium falciparum ,biology.organism_classification ,medicine.disease ,Predictive value ,General Biochemistry, Genetics and Molecular Biology ,THICK SMEAR ,malaria/diagnosis ,Test (assessment) ,Perú ,cuidados posteriores ,Medicine ,In patient ,business ,Malaria ,aftercare - Abstract
Resumen Introducción. En Perú, la microscopía óptica con gota gruesa continúa utilizándose en el seguimiento de los pacientes con malaria o paludismo. Esta prueba es sencilla, pero requiere de equipamiento microscópico y personal idóneo que realice la lectura de las muestras. Los estudios sugieren que la prueba rápida OptiMAL-IT™ es una opción para dicho seguimiento. Objetivo. Evaluar la efectividad de OptiMAL-IT™ como test de seguimiento en pacientes con malaria en áreas endémicas del Perú. Materiales y métodos. Se hizo un estudio observacional, transversal y analítico de pruebas diagnósticas en pacientes con malaria. Se seleccionó a todos los pacientes que cumplían con los criterios de inclusión, procedentes de diferentes establecimientos de salud de los departamentos peruanos de San Martín y Loreto. El diagnóstico se hizo mediante microscopía óptica con gota gruesa y la prueba rápida de diagnóstico inmunocromatográfico OptiMAL-IT™ en los días 2, 3, 7 y 14 para Plasmodium vivax y hasta el día 21 de seguimiento para Plasmodium falciparum. Se calculó el porcentaje de los correctamente clasificados y los valores predictivos, y se compararon los resultados de la selva occidental y la selva oriental mediante ji al cuadrado o prueba exacta de Fisher. Resultados. Se registraron 262 pacientes de San Martín y 302 de Loreto. Los porcentajes correctamente clasificados y el valor predictivo negativo fueron superiores a 92,0 y 93,0 %, respectivamente, a partir del tercer día de seguimiento; no se encontraron diferencias estadísticas en los resultados obtenidos en la Amazonía occidental y los de la oriental. Conclusiones. La prueba OptiMAL-IT™ sería efectiva como test de seguimiento en los pacientes con diagnóstico de malaria en áreas endémicas del Perú. Abstract Introduction: In Peru, optical microscopy with the thick smear test continues to be performed for the follow-up of malaria patients. This test is simple but it requires microscopic equipment and suitable staff to perform the reading of the samples. Studies suggest that the rapid OptiMAL-IT™ test is an option for follow-up. Objective: To evaluate the effectiveness of OptiMAL-IT™ as a follow-up test in malaria patients in endemic areas of Perú. Materials and methods: We conducted an observational, analytical cross-sectional study of diagnostic tests performed in patients with malaria. We selected all the patients attending different health facilities in the Peruvian departments of San Martín and Loreto who met the inclusion criteria. Optical microscopy with thick smear and OptiMAL-IT™ was used on days 2, 3, 7, and 14 for Plasmodium vivax and until day 21 of follow-up for Plasmodium falciparum. Percentages of correctly classified samples and predictive values were calculated, and the results were compared between the western jungle and the eastern jungle using Chi2 or Fisher's exact tests. Results: We registered 262 patients from San Martín and 302 from Loreto. The percentage of correctly classified cases and the negative predictive value were higher than 92.0% and 93,0%, respectively, from the third day of follow-up; no statistical differences were found in the results obtained from the western jungle and those from the eastern jungle. Conclusions: The OptiMAL-IT™ test would be effective as a follow-up test in patients diagnosed with malaria in endemic areas of Perú.
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- 2022
38. Inclusive and differential cross section measurements of single top quark production in association with a Z boson in proton-proton collisions at root s=13 TeV
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Tumasyan, A. Adam, W. Andrejkovic, J. W. Bergauer, T. and Chatterjee, S. Damanakis, K. Dragicevic, M. Del Valle, A. Escalante Fruhwirth, R. Jeitler, M. Krammer, N. Lechner, L. Liko, D. Mikulec, I Paulitsch, P. Pitters, F. M. and Schieck, J. Schofbeck, R. Schwarz, D. Templ, S. and Waltenberger, W. Wulz, C-E Chekhovsky, V Litomin, A. and Makarenko, V Darwish, M. R. De Wolf, E. A. Janssen, T. and Kello, T. Lelek, A. Sfar, H. Rejeb Van Mechelen, P. Van Putte, S. Van Remortel, N. Blekman, F. Bols, E. S. and D'Hondt, J. Delcourt, M. El Faham, H. Lowette, S. and Moortgat, S. Morton, A. Muller, D. Sahasransu, A. R. and Tavernier, S. Van Doninck, W. Stylianou, N. Beghin, D. and Bilin, B. Clerbaux, B. De Lentdecker, G. Favart, L. and Grebenyuk, A. Kalsi, A. K. Lee, K. Mahdavikhorrami, M. and Makarenko, I Moureaux, L. Petre, L. Popov, A. Postiau, N. Starling, E. Thomas, L. Vanden Bemden, M. Vander Velde, C. Vanlaer, P. Gao, X. Cornelis, T. Dobur, D. and Knolle, J. Lambrecht, L. Mestdach, G. Niedziela, M. and Roskas, C. Samalan, A. Skovpen, K. Tytgat, M. Vermassen, B. Wezenbeek, L. Benecke, A. Bethani, A. Bruno, G. and Bury, F. Caputo, C. David, P. Delaere, C. Donertas, I. S. Giammanco, A. Jaffel, K. Jain, Sa Lemaitre, V and Mondal, K. Prisciandaro, J. Taliercio, A. Teklishyn, M. and Tran, T. T. Vischia, P. Wertz, S. Alves, G. A. Hensel, C. Moraes, A. Teles, P. Rebello Alda Junior, W. L. Gallo Pereira, M. Alves Ferreira Filho, M. Barroso Malbouisson, H. Brandao Carvalho, W. Chinellato, J. Da Costa, E. M. Da Silveira, G. G. Damiao, D. De Jesus De Souza, S. Fonseca and Herrera, C. Mora Amarilo, K. Mota Mundim, L. Nogima, H. and Santoro, A. Silva Do Amaral, S. M. Sznajder, A. Thiel, M. and De Araujo, F. Torres Da Silva Pereira, A. Vilela Bernardes, C. A. Calligaris, L. Tomei, T. R. Fernandez Perez Gregores, E. M. Lemos, D. S. Mercadante, P. G. Novaes, S. F. and Padula, Sandra S. Aleksandrov, A. Antchev, G. Hadjiiska, R. and Iaydjiev, P. Misheva, M. Rodozov, M. Shopova, M. and Sultanov, G. Dimitrov, A. Ivanov, T. Litov, L. Pavlov, B. Petkov, P. Petrov, A. Cheng, T. Javaid, T. and Mittal, M. Yuan, L. Ahmad, M. Bauer, G. Dozen, C. and Hu, Z. Martins, J. Wang, Y. Yi, K. Chapon, E. Chen, G. M. Chen, H. S. Chen, M. Iemmi, F. Kapoor, A. and Leggat, D. Liao, H. Liu, Z-A Milosevic, V Monti, F. and Sharma, R. Tao, J. Thomas-Wilsker, J. Wang, J. Zhang, H. and Zhao, J. Agapitos, A. An, Y. Ban, Y. Chen, C. and Levin, A. Li, Q. Lyu, X. Mao, Y. Qian, S. J. Wang, D. Xiao, J. Lu, M. You, Z. Okawa, H. Zhang, Y. and Zhang, L. Lin, Z. Xiao, M. Avila, C. Cabrera, A. and Florez, C. Fraga, J. Mejia Guisao, J. Ramirez, F. Ruiz Alvarez, J. D. Salazar Gonzalez, C. A. Giljanovic, D. and Godinovic, N. Lelas, D. Puljak, I Antunovic, Z. Kovac, M. Sculac, T. Brigljevic, V Ferencek, D. Majumder, D. and Roguljic, M. Starodumov, A. Susa, T. Attikis, A. and Christoforou, K. Erodotou, E. Ioannou, A. Kole, G. and Kolosova, M. Konstantinou, S. Mousa, J. Nicolaou, C. and Ptochos, F. Razis, P. A. Rykaczewski, H. Saka, H. and Finger, M. Finger Jr, M. Jr Kveton, A. Ayala, E. Carrera Jarrin, E. Abdalla, H. Assran, Y. Lotfy, A. Mahmoud, M. A. Bhowmik, S. Dewanjee, R. K. Ehataht, K. Kadastik, M. and Nandan, S. Nielsen, C. Pata, J. Raidal, M. Tani, L. and Veelken, C. Eerola, P. Forthomme, L. Kirschenmann, H. and Osterberg, K. Voutilainen, M. Bharthuar, S. Brucken, E. and Garcia, F. Havukainen, J. Kim, M. S. Kinnunen, R. and Lampen, T. Lassila-Perini, K. Lehti, S. Linden, T. and Lotti, M. Martikainen, L. Myllymaki, M. Ott, J. and Siikonen, H. Tuominen, E. Tuominiemi, J. Luukka, P. and Petrow, H. Tuuva, T. Amendola, C. Besancon, M. Couderc, F. Dejardin, M. Denegri, D. Faure, J. L. Ferri, F. and Ganjour, S. Gras, P. de Monchenault, G. Hamel Jarry, P. and Lenzi, B. Locci, E. Malcles, J. Rander, J. Rosowsky, A. and Sahin, M. O. Savoy-Navarro, A. Titov, M. Yu, G. B. and Mijuskovic, J. Ahuja, S. Beaudette, F. Bonanomi, M. and Perraguin, A. Buchot Busson, P. Cappati, A. Charlot, C. and Davignon, O. Diab, B. Falmagne, G. Ghosh, S. de Cassagnac, R. Granier Hakimi, A. Kucher, I Motta, J. and Nguyen, M. Ochando, C. Paganini, P. Rembser, J. Salerno, R. Sarkar, U. Sauvan, J. B. Sirois, Y. Tarabini, A. and Zabi, A. Zghiche, A. Agram, J-L Andrea, J. Apparu, D. and Bloch, D. Bourgatte, G. Brom, J-M Chabert, E. C. and Collard, C. Darej, D. Fontaine, J-C Goerlach, U. and Grimault, C. Le Bihan, A-C Nibigira, E. Van Hove, P. and Asilar, E. Beauceron, S. Bernet, C. Boudoul, G. Camen, C. Carle, A. Chanon, N. Contardo, D. Depasse, P. El Mamouni, H. Fay, J. Gascon, S. Gouzevitch, M. Ille, B. and Laktineh, I. B. Lattaud, H. Lesauvage, A. Lethuillier, M. Mirabito, L. Perries, S. Shchablo, K. Sordini, V and Torterotot, L. Touquet, G. Vander Donckt, M. Viret, S. and Lomidze, I Toriashvili, T. Tsamalaidze, Z. Mestvirishvili, A. Botta, V Feld, L. Klein, K. Lipinski, M. Meuser, D. Pauls, A. Rowert, N. Schulz, J. Teroerde, M. and Dodonova, A. Eliseev, D. Erdmann, M. Fackeldey, P. and Fischer, B. Hebbeker, T. Hoepfner, K. Ivone, F. and Mastrolorenzo, L. Merschmeyer, M. Meyer, A. Mocellin, G. and Mondal, S. Mukherjee, S. Noll, D. Novak, A. Pook, T. and Pozdnyakov, A. Rath, Y. Reithler, H. Roemer, J. Schmidt, A. Schuler, S. C. Sharma, A. Vigilante, L. Wiedenbeck, S. Zaleski, S. Borras, K. Kasem, A. Coubez, X. and Dziwok, C. Flugge, G. Ahmad, W. Haj Hlushchenko, O. and Kress, T. Nowack, A. Pistone, C. Pooth, O. Roy, D. and Stahl, A. Ziemons, T. Zotz, A. Petersen, H. Aarup and Martin, M. Aldaya Asmuss, P. Baxter, S. Bayatmakou, M. and Behnke, O. Martinez, A. Bermudez Bhattacharya, S. Bin Anuar, A. A. Brunner, D. Campbell, A. Cardini, A. Cheng, C. and Colombina, F. Rodriguez, S. Consuegra Silva, G. Correia and Danilov, V De Silva, M. Didukh, L. Eckerlin, G. and Eckstein, D. Banos, L. I. Estevez Filatov, O. Gallo, E. and Geiser, A. Giraldi, A. Grohsjean, A. Guthoff, M. Jafari, A. Jomhari, N. Z. Jung, H. Kasemann, M. Kaveh, H. and Kleinwort, C. Kogler, R. Krucker, D. Lange, W. Lidrych, J. Lipka, K. Lohmann, W. Mankel, R. Melzer-Pellmann, I-A and Morentin, M. Mendizabal Metwally, J. Meyer, A. B. Meyer, M. Mnich, J. Mussgiller, A. Otarid, Y. Adan, D. Perez and Pitzl, D. Raspereza, A. Lopes, B. Ribeiro Rubenach, J. and Saggio, A. Saibel, A. Savitskyi, M. Scham, M. and Scheurer, V Schnake, S. Schutze, P. Schwanenberger, C. and Shchedrolosiev, M. Ricardo, R. E. Sosa Stafford, D. Tonon, N. Van De Klundert, M. Walsh, R. Walter, D. Wang, Q. and Wen, Y. Wichmann, K. Wiens, L. Wissing, C. Wuchterl, S. and Bakhshiansohi, H. Aggleton, R. Albrecht, S. Bein, S. and Benato, L. Connor, P. De Leo, K. Eich, M. Feindt, F. and Frohlich, A. Garbers, C. Garutti, E. Gunnellini, P. and Hajheidari, M. Haller, J. Hinzmann, A. Kasieczka, G. and Klanner, R. Kramer, T. Kutzner, V Lange, J. Lange, T. and Lobanov, A. Malara, A. Nigamova, A. Rodriguez, K. J. Pena Rieger, M. Rieger, O. Schleper, P. Schroder, M. and Schwandt, J. Sonneveld, J. Stadie, H. Steinbruck, G. and Tews, A. Zoi, I Bechtel, J. Brommer, S. Burkart, M. and Butz, E. Caspart, R. Chwalek, T. De Boer, W. Dierlamm, A. Droll, A. El Morabit, K. Faltermann, N. Giffels, M. and Gosewisch, J. O. Gottmann, A. Hartmann, F. Heidecker, C. and Husemann, U. Keicher, P. Koppenhofer, R. Maier, S. and Metzler, M. Mitra, S. Muller, Th Neukum, M. Nurnberg, A. and Quast, G. Rabbertz, K. Rauser, J. Savoiu, D. and Schnepf, M. Seith, D. Shvetsov, I Simonis, H. J. Ulrich, R. Van der Linden, J. Von Cube, R. F. Wassmer, M. Weber, M. Wieland, S. Wolf, R. Wozniewski, S. Wunsch, S. and Anagnostou, G. Daskalakis, G. Geralis, T. Kyriakis, A. and Loukas, D. Stakia, A. Diamantopoulou, M. Karasavvas, D. and Karathanasis, G. Kontaxakis, P. Koraka, C. K. and Manousakis-Katsikakis, A. Panagiotou, A. Papavergou, I and Saoulidou, N. Theofilatos, K. Tziaferi, E. Vellidis, K. and Vourliotis, E. Sphicas, P. Bakas, G. Kousouris, K. and Papakrivopoulos, I Tsipolitis, G. Zacharopoulou, A. and Adamidis, K. Bestintzanos, I Evangelou, I Foudas, C. and Gianneios, P. Katsoulis, P. Kokkas, P. Manthos, N. and Papadopoulos, I Strologas, J. Csanad, M. Farkas, K. and Gadallah, M. M. A. Lokos, S. Major, P. Mandal, K. Mehta, A. Pasztor, G. Radl, A. J. Suranyi, O. Veres, I, G. and Trocsanyi, Z. L. Bartok, M. Bencze, G. Hajdu, C. and Horvath, D. Sikler, F. Veszpremi, V. Csorgo, T. Nemes, F. Czellar, S. Fasanella, D. Karancsi, J. Molnar, J. and Szillasi, Z. Teyssier, D. Raics, P. Ujvari, B. Novak, T. and Choudhury, S. Komaragiri, J. R. Kumar, D. Panwar, L. and Tiwari, P. C. Bahinipati, S. Kar, C. Mal, P. Mishra, T. and Bindhu, V. K. Muraleedharan Nair Nayak, A. Saha, P. Sur, N. Swain, S. K. Vats, D. Bansal, S. Beri, S. B. and Bhatnagar, V Chaudhary, G. Chauhan, S. Dhingra, N. and Gupta, R. Kaur, A. Kaur, M. Kaur, S. Kumari, P. and Meena, M. Sandeep, K. Singh, J. B. Virdi, A. K. Ahmed, A. Bhardwaj, A. Choudhary, B. C. Gola, M. Keshri, S. and Kumar, A. Naimuddin, M. 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Herndon, M. Herve, A. and Hussain, U. Lanaro, A. Loeliger, A. Loveless, R. and Sreekala, J. Madhusudanan Mallampalli, A. Mohammadi, A. and Pinna, D. Savin, A. Shang, V Smith, W. H. Teague, D. and Trembath-Reichert, S. Vetens, W. CMS Collaboration
- Subjects
High Energy Physics::Phenomenology ,High Energy Physics::Experiment ,Nuclear Experiment - Abstract
Inclusive and differential cross sections of single top quark production in association with a Z boson are measured in proton-proton collisions at a center-of-mass energy of 13 TeV with a data sample corresponding to an integrated luminosity of 138 fb(-1) recorded by the CMS experiment. Events are selected based on the presence of three leptons, electrons or muons, associated with leptonic Z boson and top quark decays. The measurement yields an inclusive cross section of 87.9(-7.3)(+7.5) (stat)(-6.0)(+7.3)(syst) fb for a dilepton invariant mass greater than 30 GeV, in agreement with standard model (SM) calculations and represents the most precise determination to date. The ratio between the cross sections for the top quark and the top antiquark production in association with a Z boson is measured as 2.37(-0.42)(+0.56)(stat)(-0.13)(+0.27) (syst). Differential measurements at parton and particle levels are performed for the first time. Several kinematic observables are considered to study the modeling of the process. Results are compared to theoretical predictions with different assumptions on the source of the initial-state b quark and found to be in agreement, within the uncertainties. Additionally, the spin asymmetry, which is sensitive to the top quark polarization, is determined from the differential distribution of the polarization angle at parton level to be 0.54 +/- 0.16 (stat)+/- 0.06 (syst), in agreement with SM predictions.
- Published
- 2022
39. Measurement and QCD analysis of double-differential inclusive jet cross sections in proton-proton collisions at root s=13 TeV
- Author
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Kim, H. Luo, S. Malhotra, S. Mueller, R. Overton, D. Rathjens, D. Safonov, A. Akchurin, N. and Damgov, J. Hegde, V. Kunori, S. Lamichhane, K. Lee, S. W. Mengke, T. Muthumuni, S. Peltola, T. Volobouev, I. and Wang, Z. Whitbeck, A. Appelt, E. Greene, S. Gurrola, A. Johns, W. Melo, A. Ni, H. Padeken, K. Romeo, F. and Sheldon, P. Tuo, S. Velkovska, J. Arenton, M. W. and Cox, B. Cummings, G. Hakala, J. Hirosky, R. Joyce, M. and Ledovskoy, A. Li, A. Neu, C. Perez Lara, C. E. and Tannenwald, B. White, S. Wolfe, E. Poudyal, N. Black, K. and Bose, T. Caillol, C. Dasu, S. De Bruyn, I. and Everaerts, P. Fienga, F. Galloni, C. He, H. Herndon, M. and Herve, A. Hussain, U. Lanaro, A. Loeliger, A. and Loveless, R. Madhusudanan Sreekala, J. Mallampalli, A. and Mohammadi, A. Pinna, D. Savin, A. Shang, V. Sharma, V. and Smith, W. H. Teague, D. Trembath-Reichert, S. Vetens, W. and CMS Collaboration
- Subjects
High Energy Physics::Phenomenology ,High Energy Physics::Experiment - Abstract
A measurement of the inclusive jet production in proton-proton collisions at the LHC at root s = 13TeV is presented. The double-differential cross sections are measured as a function of the jet transverse momentum p(T) and the absolute jet rapidity vertical bar y vertical bar. The anti- k(T) clustering algorithm is used with distance parameter of 0.4 (0.7) in a phase space region with jet p(T) from 97 GeV up to 3.1TeV and vertical bar y vertical bar < 2.0. Data collected with the CMS detector are used, corresponding to an integrated luminosity of 36.3 fb(-1) (33.5 fb(-1)). The measurement is used in a comprehensive QCD analysis at next-to-next-to-leading order, which results in significant improvement in the accuracy of the parton distributions in the proton. Simultaneously, the value of the strong coupling constant at the Z boson mass is extracted as alpha(S)(m(Z)) = 0.1170 +/- 0.0019. For the first time, these data are used in a standard model effective field theory analysis at next-to-leading order, where parton distributions and the QCD parameters are extracted simultaneously with imposed constraints on the Wilson coefficient c(1) of 4-quark contact interactions.
- Published
- 2022
40. Search for flavor-changing neutral current interactions of the top quark and the Higgs boson decaying to a bottom quark-antiquark pair at root s=13 TeV
- Author
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- Subjects
High Energy Physics::Phenomenology ,High Energy Physics::Experiment - Abstract
A search for flavor-changing neutral current interactions of the top quark (t) and the Higgs boson (H) is presented. The search is based on a data sample corresponding to an integrated luminosity of 137 fb(-1) recorded by the CMS experiment at the LHC in proton-proton collisions at root s = 13TeV. Events containing exactly one lepton (muon or electron) and at least three jets, among which at least two are identified as originating from the hadronization of a bottom quark, are analyzed. A set of deep neural networks is used for kinematic event reconstruction, while boosted decision trees distinguish the signal from the background events. No significant excess over the background predictions is observed, and upper limits on the signal production cross sections are extracted. These limits are interpreted in terms of top quark decay branching fractions (B) to the Higgs boson and an up (u) or a charm quark (c). Assuming one nonvanishing extra coupling at a time, the observed (expected) upper limits at 95% confidence level are B(t -> Hu) < 0.079 (0.11)% and B(t -> Hc) < 0.094 (0.086)%.
- Published
- 2022
41. Search for long-lived particles decaying to leptons with large impact parameter in proton-proton collisions at root s=13 TeV
- Author
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Gutierrez, G. Reales Rieger, M. and Rovere, M. Sakulin, H. Salfeld-Nebgen, J. Scarfi, S. and Schafer, C. Schwick, C. Selvaggi, M. Silva, P. Snoeys, W. Sphicas, P. Summers, S. Tatar, K. Tavolaro, V. R. and Treille, D. Tropea, P. Tsirou, A. Van Onsem, G. P. and Wanczyk, J. Wozniak, K. A. Zeuner, W. D. Caminada, L. and Ebrahimi, A. Erdmann, W. Horisberger, R. Ingram, Q. and Kaestli, H. C. Kotlinski, D. Langenegger, U. Missiroli, M. and Noehte, L. Rohe, T. Androsov, K. Backhaus, M. and Berger, P. Calandri, A. De Cosa, A. Dissertori, G. and Dittmar, M. Donega, M. Dorfer, C. Eble, F. Gedia, K. and Glessgen, F. Espinosa, T. A. Gomez Grab, C. Hits, D. and Lustermann, W. Lyon, A-M Manzoni, R. A. Marchese, L. and Perez, C. Martin Meinhard, M. T. Nessi-Tedaldi, F. and Niedziela, J. Pauss, F. Perovic, V Pigazzini, S. Ratti, M. G. Reichmann, M. Reissel, C. Reitenspiess, T. Ristic, B. Ruini, D. Becerra, D. A. Sanz Stampf, V Steggemann, J. Wallny, R. Zhu, D. H. Amsler, C. Bartschi, P. and Botta, C. Brzhechko, D. Canelli, M. F. Cormier, K. De Wit, A. Del Burgo, R. Heikkila, J. K. Huwiler, M. Jin, W. Jofrehei, A. Kilminster, B. Leontsinis, S. Liechti, S. P. Macchiolo, A. Meiring, P. Mikuni, V. M. Molinatti, U. Neutelings, I Reimers, A. Robmann, P. Cruz, S. Sanchez Schweiger, K. Senger, M. Takahashi, Y. Adloff, C. Kuo, C. M. Lin, W. Roy, A. Sarkar, T. Yu, S. S. and Ceard, L. Chao, Y. Chen, K. F. Chen, P. H. Hou, W-S and Li, Y. Y. Lu, R-S Paganis, E. Psallidas, A. Steen, A. Wu, H. Y. Yazgan, E. Yu, P. R. Asavapibhop, B. and Asawatangtrakuldee, C. Srimanobhas, N. Boran, F. and Damarseckin, S. Demiroglu, Z. S. Dolek, F. Dumanoglu, I and Eskut, E. Guler, Y. Guler, E. Gurpinar Isik, C. Kara, O. and Topaksu, A. Kayis Kiminsu, U. Onengut, G. Ozdemir, K. and Polatoz, A. Simsek, A. E. Tali, B. Tok, U. G. and Turkcapar, S. Zorbakir, I. S. Isildak, B. Karapinar, G. and Ocalan, K. Yalvac, M. Akgun, B. Atakisi, I. O. Gulmez, E. Kaya, M. Kaya, O. Tekten, S. Yetkin, E. A. Cakir, A. Cankocak, K. Komurcu, Y. Sen, S. Cerci, S. Hos, I and Kaynak, B. Ozkorucuklu, S. Cerci, D. Sunar Zorbilmez, C. and Grynyov, B. Levchuk, L. Anthony, D. Bhal, E. and Bologna, S. Brooke, J. J. Bundock, A. Clement, E. and Cussans, D. Flacher, H. Goldstein, J. Heath, G. P. and Heath, H. F. Kreczko, L. Krikler, B. Paramesvaran, S. El Nasr-Storey, S. Seif Smith, V. J. Stylianou, N. Pass, K. Walkingshaw White, R. Bell, K. W. Brew, C. Brown, R. M. and Cockerill, D. J. A. Cooke, C. Ellis, V, K. Harder, K. and Harper, S. Holmberg, M. L. Linacre, J. Manolopoulos, K. and Newbold, D. M. Olaiya, E. Petyt, D. Reis, T. Schuh, T. Shepherd-Themistocleous, C. H. Tomalin, I. R. Williams, T. Bainbridge, R. Bloch, P. Bonomally, S. Borg, J. and Breeze, S. Buchmuller, O. Cepaitis, V Chahal, G. S. and Colling, D. Dauncey, P. Davies, G. Della Negra, M. and Fayer, S. Fedi, G. Hall, G. Hassanshahi, M. H. Iles, G. and Langford, J. Lyons, L. Magnan, A-M Malik, S. and Martelli, A. Monk, D. G. Nash, J. Pesaresi, M. Raymond, D. M. Richards, A. Rose, A. Scott, E. Seez, C. and Shtipliyski, A. Tapper, A. Uchida, K. Virdee, T. and Vojinovic, M. Wardle, N. Webb, S. N. Winterbottom, D. and Coldham, K. Cole, J. E. Khan, A. Kyberd, P. Reid, I. D. and Teodorescu, L. Zahid, S. Abdullin, S. Brinkerhoff, A. and Caraway, B. Dittmann, J. Hatakeyama, K. Kanuganti, A. R. and McMaster, B. Pastika, N. Saunders, M. Sawant, S. and Sutantawibul, C. Wilson, J. Bartek, R. Dominguez, A. and Uniyal, R. Hernandez, A. M. Vargas Buccilli, A. Cooper, I, S. Di Croce, D. Gleyzer, V, S. Henderson, C. Perez, C. U. Rumerio, P. West, C. Akpinar, A. Albert, A. and Arcaro, D. Cosby, C. Demiragli, Z. Fontanesi, E. and Gastler, D. May, S. Rohlf, J. Salyer, K. Sperka, D. and Spitzbart, D. Suarez, I Tsatsos, A. Yuan, S. Zou, D. and Benelli, G. Burkle, B. Coubez, X. Cutts, D. Hadley, M. and Heintz, U. Hogan, J. M. Kwon, T. Landsberg, G. Lau, K. T. Li, D. Lukasik, M. Luo, J. Narain, M. Pervan, N. Sagir, S. Simpson, F. Usai, E. Wong, W. Y. Yan, X. Yu, D. Zhang, W. Bonilla, J. Brainerd, C. and Breedon, R. Sanchez, M. Calderon De La Barca Chertok, M. and Conway, J. Cox, P. T. Erbacher, R. Haza, G. Jensen, F. and Kukral, O. Lander, R. Mulhearn, M. Pellett, D. and Regnery, B. Taylor, D. Yao, Y. Zhang, F. Bachtis, M. and Cousins, R. Datta, A. Hamilton, D. Hauser, J. Ignatenko, M. Iqbal, M. A. Lam, T. Nash, W. A. Regnard, S. and Saltzberg, D. Stone, B. Valuev, V. Burt, K. Chen, Y. and Clare, R. Gary, J. W. Gordon, M. Hanson, G. Karapostoli, G. Long, O. R. Manganelli, N. Negrete, M. Olmedo Si, W. and Wimpenny, S. Branson, J. G. Chang, P. Cittolin, S. and Cooperstein, S. Deelen, N. Diaz, D. Duarte, J. Gerosa, R. Giannini, L. Guiang, J. Kansal, R. Krutelyov, V and Lee, R. Letts, J. Masciovecchio, M. Mokhtar, F. Pieri, M. Narayanan, B. V. Sathia Sharma, V Tadel, M. Vartak, A. Wurthwein, F. Xiang, Y. Yagil, A. Amin, N. and Campagnari, C. Citron, M. Dorsett, A. Dutta, V and Incandela, J. Kilpatrick, M. Marsh, B. Mei, H. Oshiro, M. Quinnan, M. Richman, J. Sarica, U. Setti, F. and Sheplock, J. Stuart, D. Wang, S. Bornheim, A. Cerri, O. and Dutta, I Lawhorn, J. M. Lu, N. Mao, J. Newman, H. B. and Nguyen, T. Q. Spiropulu, M. Vlimant, J. R. Wang, C. and Xie, S. Zhang, Z. Zhu, R. Y. Alison, J. An, S. and Andrews, M. B. Bryant, P. Ferguson, T. Harilal, A. Liu, C. Mudholkar, T. Paulini, M. Sanchez, A. Terrill, W. and Cumalat, J. P. Ford, W. T. Hassani, A. MacDonald, E. and Patel, R. Perloff, A. Savard, C. Stenson, K. Ulmer, K. A. Wagner, S. R. Alexander, J. Bright-thonney, S. Chen, X. Cheng, Y. Cranshaw, D. J. Hogan, S. Monroy, J. and Patterson, J. R. Quach, D. Reichert, J. Reid, M. Ryd, A. and Sun, W. Thom, J. Wittich, P. Zou, R. Albrow, M. and Alyari, M. Apollinari, G. Apresyan, A. Apyan, A. and Bauerdick, L. A. T. Berry, D. Berryhill, J. Bhat, P. C. and Burkett, K. Butler, J. N. Canepa, A. Cerati, G. B. and Cheung, H. W. K. Chlebana, F. Di Petrillo, K. F. Elvira, V. D. Feng, Y. Freeman, J. Gecse, Z. Gray, L. Green, D. and Grunendahl, S. Gutsche, O. Harris, R. M. Heller, R. and Herwig, T. C. Hirschauer, J. Jayatilaka, B. Jindariani, S. and Johnson, M. Joshi, U. Klijnsma, T. Klima, B. Kwok, K. H. M. Lammel, S. Lincoln, D. Lipton, R. Liu, T. and Madrid, C. Maeshima, K. Mantilla, C. Mason, D. McBride, P. Merkel, P. Mrenna, S. Nahn, S. Ngadiuba, J. and O'Dell, V Papadimitriou, V Pedro, K. Pena, C. Prokofyev, O. Ravera, F. Hall, A. Reinsvold Ristori, L. and Sexton-Kennedy, E. Smith, N. Soha, A. Spalding, W. J. and Spiegel, L. Stoynev, S. Strait, J. Taylor, L. Tkaczyk, S. Tran, V, N. Uplegger, L. Vaandering, E. W. Weber, H. A. Acosta, D. Avery, P. Bourilkov, D. Cadamuro, L. and Cherepanov, V Errico, F. Field, R. D. Guerrero, D. and Joshi, B. M. Kim, M. Koenig, E. Konigsberg, J. Korytov, A. Lo, K. H. Matchev, K. Menendez, N. Mitselmakher, G. and Madhu, A. Muthirakalayil Rawal, N. Rosenzweig, D. and Rosenzweig, S. Rotter, J. Shi, K. Sturdy, J. Yigitbasi, E. Zuo, X. Adams, T. Askew, A. Habibullah, R. and Hagopian, V Johnson, K. F. Khurana, R. Kolberg, T. and Martinez, G. Prosper, H. Schiber, C. Viazlo, O. Yohay, R. Zhang, J. Baarmand, M. M. Butalla, S. Elkafrawy, T. and Hohlmann, M. Verma, R. Kumar Noonan, D. Rahmani, M. and Yumiceva, F. Adams, M. R. Gonzalez, H. Becerril Cavanaugh, R. Dittmer, S. Evdokimov, O. Gerber, C. E. Hangal, D. A. and Hofman, D. J. Merrit, A. H. Mills, C. Oh, G. Roy, T. and Rudrabhatla, S. Tonjes, M. B. Varelas, N. Viinikainen, J. Wang, X. Wu, Z. Ye, Z. Alhusseini, M. Dilsiz, K. and Gandrajula, R. P. Koseyan, O. K. Merlo, J-P and Mestvirishvili, A. Nachtman, J. Ogul, H. Onel, Y. Penzo, A. Snyder, C. Tiras, E. Amram, O. Blumenfeld, B. and Corcodilos, L. Davis, J. Eminizer, M. Gritsan, V, A. and Kyriacou, S. Maksimovic, P. Roskes, J. Swartz, M. Vami, T. A. Abreu, A. Anguiano, J. Barrera, C. Baldenegro and Baringer, P. Bean, A. Bylinkin, A. Flowers, Z. Isidori, T. Khalil, S. King, J. Krintiras, G. Kropivnitskaya, A. and Lazarovits, M. Le Mahieu, C. Lindsey, C. Marquez, J. and Minafra, N. Murray, M. Nickel, M. Rogan, C. Royon, C. and Salvatico, R. Sanders, S. Schmitz, E. Smith, C. and Takaki, J. D. Tapia Warner, Z. Williams, J. Wilson, G. and Duric, S. Ivanov, A. Kaadze, K. Kim, D. Maravin, Y. and Mitchell, T. Modak, A. Nam, K. Rebassoo, F. Wright, D. and Adams, E. Baden, A. Baron, O. Belloni, A. Eno, S. C. and Hadley, N. J. Jabeen, S. Kellogg, R. G. Koeth, T. and Mignerey, A. C. Nabili, S. Palmer, C. Seidel, M. Skuja, A. Wang, L. Wong, K. Abercrombie, D. Andreassi, G. and Bi, R. Busza, W. Cali, I. A. D'Alfonso, M. Eysermans, J. and Freer, C. Ceballos, G. Gomez Goncharov, M. Harris, P. and Hu, M. Klute, M. Kovalskyi, D. Krupa, J. Lee, Y-J and Mironov, C. Paus, C. Rankin, D. Roland, C. Roland, G. Shi, Z. Stephans, G. S. F. Wang, Z. Wyslouch, B. and Chatterjee, R. M. Evans, A. Hiltbrand, J. Jain, Sh and Krohn, M. Kubota, Y. Mans, J. Revering, M. Rusack, R. and Saradhy, R. Schroeder, N. Strobbe, N. Wadud, M. A. and Bloom, K. Bryson, M. Claes, D. R. Fangmeier, C. Finco, L. Golf, F. Joo, C. Kravchenko, I Musich, M. Reed, I and Siado, J. E. Snow, G. R. Tabb, W. Yan, F. and Zecchinelli, A. G. Agarwal, G. Bandyopadhyay, H. Hay, L. and Iashvili, I. Kharchilava, A. McLean, C. Nguyen, D. and Pekkanen, J. Rappoccio, S. Williams, A. Alverson, G. and Barberis, E. Haddad, Y. Hortiangtham, A. Li, J. Madigan, G. Marzocchi, B. Morse, D. M. Nguyen, V Orimoto, T. and Parker, A. Skinnari, L. Tishelman-Charny, A. Wamorkar, T. and Wang, B. Wisecarver, A. Wood, D. Bueghly, J. Chen, Z. Gilbert, A. Gunter, T. Hahn, K. A. Liu, Y. Odell, N. Schmitt, M. H. Velasco, M. Band, R. Bucci, R. and Cremonesi, M. Das, A. Dev, N. Goldouzian, R. Hildreth, M. Anampa, K. Hurtado Jessop, C. Lannon, K. Lawrence, J. and Loukas, N. Lutton, D. Marinelli, N. Mcalister, I and McCauley, T. Mcgrady, C. Mohrman, K. Moore, C. Musienko, Y. Ruchti, R. Siddireddy, P. Townsend, A. Wayne, M. and Wightman, A. Zarucki, M. Zygala, L. Bylsma, B. Cardwell, B. Durkin, L. S. Francis, B. Hill, C. Ornelas, M. Nunez and Wei, K. Winer, B. L. Yates, B. R. Addesa, F. M. and Bonham, B. Das, P. Dezoort, G. Elmer, P. Frankenthal, A. and Greenberg, B. Haubrich, N. Higginbotham, S. and Kalogeropoulos, A. Kopp, G. Kwan, S. Lange, D. Marlow, D. Mei, K. Ojalvo, I Olsen, J. Stickland, D. Tully, C. Norberg, S. Bakshi, A. S. Barnes, V. E. Chawla, R. and Das, S. Gutay, L. Jones, M. Jung, A. W. Karmarkar, S. Kondratyev, D. Liu, M. Negro, G. Neumeister, N. and Paspalaki, G. Piperov, S. Purohit, A. Schulte, J. F. and Stojanovic, M. Thieman, J. Wang, F. Xiao, R. Xie, W. and Dolen, J. Parashar, N. Baty, A. Carnahan, T. Decaro, M. and Dildick, S. Ecklund, K. M. Freed, S. Gardner, P. and Geurts, F. J. M. Li, W. Padley, B. P. Redjimi, R. Shi, W. Leiton, A. G. Stahl Zhang, L. Bodek, A. de Barbaro, P. Demina, R. Dulemba, J. L. Fallon, C. Ferbel, T. and Galanti, M. Garcia-Bellido, A. Hindrichs, O. and Khukhunaishvili, A. Ranken, E. Taus, R. Chiarito, B. and Chou, J. P. Gandrakota, A. Gershtein, Y. Halkiadakis, E. and Hart, A. Heindl, M. Karacheban, O. Laflotte, I Lath, A. and Montalvo, R. Nash, K. Osherson, M. Salur, S. and Schnetzer, S. Somalwar, S. Stone, R. Thayil, S. A. and Thomas, S. Wang, H. Acharya, H. Delannoy, A. G. and Fiorendi, S. Spanier, S. Bouhali, O. Dalchenko, M. and Delgado, A. Eusebi, R. Gilmore, J. Huang, T. Kamon, T. and Luo, S. Malhotra, S. Mueller, R. Overton, D. and Rathjens, D. Safonov, A. Akchurin, N. Damgov, J. Hegde, V Kunori, S. Lamichhane, K. Mengke, T. Muthumuni, S. and Peltola, T. Volobouev, I Whitbeck, A. Appelt, E. Greene, S. Gurrola, A. Johns, W. Melo, A. Ni, H. Padeken, K. and Romeo, F. Sheldon, P. Tuo, S. Velkovska, J. Arenton, M. W. Cox, B. Cummings, G. Hakala, J. Hirosky, R. and Joyce, M. Ledovskoy, A. Li, A. Neu, C. Lara, C. E. Perez and Tannenwald, B. White, S. Wolfe, E. Poudyal, N. and Black, K. Bose, T. Caillol, C. Dasu, S. De Bruyn, I and Everaerts, P. Fienga, F. Galloni, C. He, H. Herndon, M. and Herve, A. Hussain, U. Lanaro, A. Loeliger, A. and Loveless, R. Sreekala, J. Madhusudanan Mallampalli, A. and Mohammadi, A. Pinna, D. Savin, A. Shang, V Smith, W. H. and Teague, D. Trembath-Reichert, S. Vetens, W. CMS Collaboration
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High Energy Physics::Experiment - Abstract
A search for new long-lived particles decaying to leptons using proton-proton collision data produced by the CERN LHC at root s = 13 TeV is presented. Events are selected with two leptons (an electron and a muon, two electrons, or two muons) that both have transverse impact parameter values between 0.01 and 10 cm and are not required to form a common vertex. Data used for the analysis were collected with the CMS detector in 2016, 2017, and 2018, and correspond to an integrated luminosity of 118 (113) fb(-1) in the ee channel (e mu and mu mu channels). The search is designed to be sensitive to a wide range of models with displaced e mu ee, and mu mu final states. The results constrain several well-motivated models involving new long-lived particles that decay to displaced leptons. For some areas of the available phase space, these are the most stringent constraints to date.
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- 2022
42. OS FATORES RELACIONADOS À SOBRECARGA DE TRABALHO EM CUIDADORES DE IDOSOS: UMA REVISÃO DE LITERATURA
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F. M. DAMASCENO, C. A. MORAIS, L. L. GURGEL, R. L. VASCONCELOS, A. A. SILVA, F. J. ARAUJO FILHO, F. M. SOUSA, and K. S. SILVA
- Published
- 2022
- Full Text
- View/download PDF
43. Development of self-healing rubber biocomposites: a sustainable approach - bioHEAL
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S. Utrera-Barrios, J. Araujo-Morera, O. Ricciardi, R. Verdejo, M. López-Manchado, and M. Hernandez Santana
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- 2022
- Full Text
- View/download PDF
44. Initiation of breeding programs for three species of Corymbia: introduction and provenances study
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Paulo H.M. da Silva, David J. Lee, Marcos R. Amancio, and Marcio J. Araujo
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new species ,VARIEDADES VEGETAIS ,growth ,basic density ,General Earth and Planetary Sciences ,Bark content ,provenance effect ,Agronomy and Crop Science ,Biotechnology ,General Environmental Science - Abstract
The objective of this study was to establish populations to start the breeding program of three species of Corymbia that are not widely planted in Brazil yet. To this end, basic density, bark content and growth of seedlots/provenances were evaluated three years after planting. The experiments consisted of 14 treatments for Corymbia citriodora subsp. variegata (CCV), 15 for C. maculata (CM), and five for C. henryi (CH). The species exhibited high survival, indicating adaptation to the Cwa climate while average coefficients of determination of seedlots exhibited intermediate values. The CCV from the Richmond Range (28º 55’ S) exhibited the highest productivity. The mean annual increment was low (22 to 26 m3ha-1), but the basic density (573 to 613 kg m-³) was high compared to the standard for eucalypts in Brazil. The bark content was close to 15% and varied between and within species.
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- 2022
45. Sleep timing, chronotype, and posttraumatic stress disorder: An individual participant data meta-analysis
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Alyson K. Zalta, Kathryn Vanderboll, Amy L. Dent, Isaias M. Contreras, Nadia Malek, Xrystyan N. Lascano, Kelly L. Zellner, Jyotsna Grandhi, Precious J. Araujo, Kelci Straka, Cathy Z. Liang, Jordyn E. Czarny, Jazmin Martinez, and Helen J. Burgess
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Psychiatry and Mental health ,Biological Psychiatry - Published
- 2023
- Full Text
- View/download PDF
46. La cultura organizacional innovadora desde una perspectiva valorativa
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Alice J. Araujo Lobo
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innovación ,cultura ,cultura organizacional ,cultura organizacional innovadora ,Management. Industrial management ,HD28-70 ,Business ,HF5001-6182 - Abstract
Al hablar de cultura innovadora en las organizaciones, es imprescindible referirse a la cultura de su entorno debido a que las organizaciones son sistemas sociales abier tos, en permanente interacción con la sociedad y conformadas por hombres quienes, al mismo tiempo, son miembros de una sociedad y ciudadanos de un país. En el presente ar tículo se arguye cómo sustituir una determinada cultura organizacional por otra, caracterizada por la innovación, o simplemente crear una cultura organizacional innovadora, significa cambiar paradigmas o cambiar la representación social acerca de las organizaciones y sus miembros, a través de la implantación de nuevos valores y principios relacionados, principalmente, con la creatividad, la confianza, la cooperación, la investigación y el auto-aprendizaje. Se recurre al análisis documental, la abducción inferencial y el racionamiento lógico y se concluye con la presentación de un modelo para implantar un cambio en la cultura organizacional.
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- 2010
47. The Impact of
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Emily M T, Padhi, Karla J, Araujo, Elizabeth, Mitrovic, Marylou, Polek, Kris E, Godfrey, and Carolyn M, Slupsky
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Hemiptera ,Citrus ,Liberibacter ,Rhizobiaceae ,Animals ,Plant Diseases - Abstract
'
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- 2021
48. The Pursuit of Sustainability
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David L. Rainey, Robert J. Araujo
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- 2011
49. LB0002 BARICITINIB IN JUVENILE IDIOPATHIC ARTHRITIS: A PHASE 3, DOUBLE-BLIND, PLACEBO-CONTROLLED, WITHDRAWAL, EFFICACY AND SAFETY STUDY
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A. Ramanan, P. Quartier, N. Okamoto, G. Meszaros, J. Araujo, Z. Wang, R. Liao, B. Crowe, X. Zhang, R. Decker, S. Keller, H. Brunner, and N. Ruperto
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Rheumatology ,Immunology ,Immunology and Allergy ,General Biochemistry, Genetics and Molecular Biology - Abstract
BackgroundBaricitinib is a JAK1/2 selective inhibitor approved for the treatment of rheumatoid arthritis. Juvenile idiopathic arthritis (JIA) is a group of diseases characterized by immune mediated chronic arthritis which often requires treatment with conventional synthetic or biologic disease-modifying antirheumatic drugs (cs or b-DMARDs).ObjectivesTo investigate baricitinib efficacy and safety in pediatric patients with JIA and an inadequate response to cs or b-DMARDs.MethodsThis Phase 3 multicenter, double-blind, withdrawal, efficacy, and safety study, enrolled patients (pts) age 2 to NCT03773978). There were 3 periods: a 2-week (wk) pharmacokinetic/safety assessment (PKS), a 12-wk open-label lead-in (OLLI), and an up-to 32-wk double-blind withdrawal (DBW). Dosage and safety were confirmed in the PKS and then pts, including those from the PKS, enrolled in the OLLI, receiving age-based, oral, once daily doses of baricitinib. Pts with a JIA-ACR30 response at wk12, end of OLLI, entered the DBW to be randomized 1:1 to continued baricitinib or newly started placebo (PBO) and remained until flare or up to wk32. Primary endpoint was time to flare during the DBW. Secondary endpoints included JIA-ACR30/50/70/90 response rates at wk12, and proportion of pts with a flare during the DBW. Survival curves were estimated using the Kaplan-Meier method.ResultsOf 220 pts enrolled, 29 participated in the PKS, 219 entered the OLLI, and 163 entered the DBW. The JIA-ACR30/50/70/90 response at wk12 was 76.3%/63.5%/46.1%/20.1%, respectively. During the DBW, time of flare was significantly shorter with PBO vs baricitinib (hazard ratio 0.24 [95% CI 0.13,0.45], pTable 1.Safety dataEvents, N (%)PKS and OLLI (N=220)Events, N (%)DBW Placebo (N=81)DBW Baricitinib (N=82)Discontinuations due to AEs2 (0.9)2 (2.5)1 (1.2)TEAEs126 (57.3)38 (46.9)54 (65.9)most common TEAEsNasopharyngitis19 (8.6)URTI1 (1.2)9 (11.0)Headache14 (6.4)Headache3 (3.7)9 (11.0)Arthralgia12 (5.5)Nasopharyngitis3 (3.7)6 (7.3)URTI11 (5.0)Arthralgia3 (3.7)6 (7.3)Nausea11 (5.0)Oropharyngeal pain1 (1.2)5 (6.1)SAEs6 (2.7)3 (3.7)4 (4.9)All reported SAEsArthralgia1 (0.5)COVID-1901 (1.2)Joint Destruction1 (0.5)Gastroenteritis01 (1.2)Joint Effusion1 (0.5)Headache01 (1.2)JIA1 (0.5)Pulmonary Embolism01 (1.2)Musculoskeletal Chest Pain1 (0.5)Bronchospasm1 (1.2)0Decreased Appetite1 (0.5)JIA1 (1.2)0Suicide Attempt1 (1.2)0Potential opportunistic infections2 (0.9)1 (1.2)1 (1.2)Herpes virus1 (0.5)Herpes virus1 (1.2)0Herpes zoster1 (0.5)Candida01 (1.2)URTI= Upper Respiratory Tract InfectionConclusionBaricitinib significantly reduced time to and frequency of JIA flares in pts with JIA versus PBO, and improved JIA-ACR scores in the majority of pts within 12wks. Safety findings were consistent with the known safety profile in adult rheumatoid arthritis indications. These findings support baricitinib as a treatment for signs and symptoms of JIA with an inadequate response to cs or b-DMARDs.References[1]Giannini EH, et. al. Preliminary definition of improvement in juvenile arthritis. Arthritis Rheum 1997; 40: 1202-1209.[2]Brunner HI, et. al. Preliminary definition of disease flare in juvenile rheumatoid arthritis. J Rheumatol 2002; 29(5):1058-64.Disclosure of InterestsAthimalaipet Ramanan Consultant of: Eli Lilly and Company, Abbvie, Roche, UCB, Novartis, Pfizer, and Sobi, Grant/research support from: Eli Lilly and Company, Pierre Quartier Consultant of: Eli Lilly and Company, Abbvie, Amgen, BMS, Novartis, Novimmune, Pfizer, Swedish Orphan Biovitrum, SANOFI, Speakers bureau: Abbvie, Novartis, Pfizer, Swedish Orphan Biovitrum, Nami Okamoto Consultant of: Swedish Orphan Biovitrum, Eli Lilly and Company, Speakers bureau: AbbVie, Eli Lilly and Company, Sanofi, Asahi Kasei Medical, Mitsubishi Tanabe Pharma, Bristol Myers Squibb, Pfizer Japan, Ayumi Pharma, Eisai, Torii Pharma, GlaxoSmithKline, Kyorin Pharma, Novartis, Chugai Pharmaceutical, Teijin Pharma, Gabriella Meszaros Employee of: Eli Lilly and Company, Joana Araujo Employee of: Eli Lilly and Company, Zhongkai Wang Employee of: Eli Lilly and Company, Ran Liao Employee of: Eli Lilly and Company, Brenda Crowe Employee of: Eli Lilly and Company, Xin Zhang Employee of: Eli Lilly and Company, Rodney Decker Employee of: Eli Lilly and Company, Stuart Keller Employee of: Eli Lilly and Company, Hermine Brunner Consultant of: AbbVie, Astra Zeneca-Medimmune, Biogen, Boehringer, Bristol-Myers Squibb, Celgene, Eli Lilly, EMD Serono, Idorsia, Cerocor, Janssen, GlaxoSmithKline, F. Hoffmann-La Roche, Merck, Novartis, R-Pharm, Sanofi, Speakers bureau: Novartis, Pfizer, GlaxoSmithKline, Nicolino Ruperto Consultant of: Eli Lilly and Company, Ablynx, Amgen, Astrazeneca-Medimmune, Aurinia, Bayer, Bristol Myers and Squibb, Cambridge Healthcare Research (CHR), Celgene, Domain therapeutic, Eli-Lilly, EMD Serono, Glaxo Smith and Kline, Idorsia, Janssen, Novartis, Pfizer, Sobi, UCB, Speakers bureau: Eli Lilly and Company, Glaxo Smith and Kline, Pfizer, Sobi, UCB
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- 2022
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50. P04 - Topic: AS01-Diagnosis/AS01c-Molecular aberrations (cytogenetic, genetic, gene expression): PRESENCE OF PD-L1 IN MEGAKARYOCYTES OF PATIENTS WITH MYELODYSPLASTIC SYNDROME
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Garcia, Y. Oliveira, Rosales, Y. Zelaya, Moura, A. Gadelha, Duarte, B., Duarte, I., Duarte, J. Araujo, Duarte, F., and Lemes, R.
- Published
- 2021
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