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Non-governmental organizations (NGOs) provide an important resource to good governance involving complex issues of environmental security. We explore that role by looking at recent campaigns concerned with security at the coal–water nexus in India and China, undertaken by regional arms of Greenpeace, an important international NGO. We find that, at the national level, the impact of NGOs on environmental governance depends deeply on an organization’s relation to government. In China, Greenpeace East Asia serves the government’s interest by providing an external source of information on activities and perceptions at the provincial level. An NGO such as Greenpeace East Asia is perceived as valuable and is tolerated as long as it acts in accordance with the unwritten rules of engagement with the government, as practiced by domestic NGOs. Greenpeace India, by comparison, is one among many NGOs, tolerated as a matter of democratic principle, but suspect because of its international connections. Greenpeace India has yet to have a meaningful impact on governance at the coal–water nexus. Greenpeace East Asia, on the other hand, appears to have found a role that can impact environmental governance, but is dependent upon operating within bounds that are set by the Chinese model of government.

In 1979, under pressure from Congress, the National Science Foundation (NSF) founded the Experimental Program to Stimulate Competitive Research (EPSCoR). Initially conceived as a means to foster scientific competitiveness in states that had not historically won many federal research dollars, EPSCoR has evolved into a program that fosters science-based economic development, an extension of the best science paradigm on which NSF and EPSCoR were founded. This article traces the evolution of EPSCoR, showing why state governments have had rational incentives to use EPSCoR to serve an economic development agenda, examining how the institutions erected to govern it inadvertently allowed EPSCoR states to incorporate economic development as a motivating force, and documenting the increasing economic development orientation of successful EPSCoR proposals and programs. The article concludes with some observations on the potential trade-offs between best science and economic development and offers some suggestions for further research.

A sample of Lambda's produced in 2 A*GeV Ni + Cu collisions has been obtained with the EOS Time Projection Chamber at the Bevalac. Low background in the invariant mass distribution allows for the unambiguous demonstration of Lambda directed flow. The transverse mass spectrum at mid-rapidity has the characteristic shoulder-arm shape of particles undergoing radial transverse expansion. A linear dependence of Lambda multiplicity on impact parameter is observed, from which a total Lambda + Sigma^0 production cross section of $112 +/- 24 mb is deduced. Detailed comparisons with the ARC and RVUU models are made.

Transverse kinetic energies of individual fragments have been measured over a broad range of emitter excitation energies for the reaction 1AGeV Au+C. For excitation energies leading to large intermediate mass fragment multiplicities, these transverse energies require large collective radial expansion of the emitting systems. However, the traditional decomposition of the transverse energy into a thermal component and a Coulomb and collective component proportional to the fragment mass cannot account for this expansion. Expansion velocities show an increase with decreasing fragment Z and thus indicate fractionation of the collective energy for the expanding system. This collective energy increases with emitter excitation up to about 50{percent} of the energy deposited for a nuclear system with total energy {approximately}12AMeV. The bulk of the collective energy is carried away by ejectiles of Z{le}3. {copyright} {ital 1998} {ital The American Physical Society}

Invariant mass analyses of (p,{pi}{sup {plus_minus}}) pairs in {sup 58}Ni+Cu collisions at 1.97A GeV have been performed and show correlations resulting from the decays of the {Delta} resonance, the {Lambda} baryon, and possibly the N{sup {asterisk}}(1440) resonance. A reduction in the {Delta} mass is observed and the mass reduction increases with collision centrality. Events generated by the relativistic cascade model (ARC) also reveal a mass reduction. The mass reduction is related to the size of the reaction volume and the details of {Delta} production mechanisms in heavy ion collisions. {copyright} {ital 1997} {ital The American Physical Society}

We study the energy dependence of collective (hydrodynamic-like) nuclear matter flow in (400{endash}1970){ital A} MeV Ni+Au and (1000{endash}1970){ital A} MeV Ni+Cu reactions. The flow increases with energy, appears to reach a maximum, and then to decrease at higher energies. A way of comparing the energy dependence of flow values for different projectile-target mass combinations is introduced, which demonstrates a more-or-less common scaling behavior among flow values from different systems. {copyright} {ital 1997} {ital The American Physical Society}

We examine the average cluster distribution as a function of lattice probability for a very small $(L=6)$ lattice and determine the scaling function of three-dimensional percolation. The behavior of the second moment, calculated from the average cluster distribution of $L=6$ and $L=63$ lattices, is compared to power-law behavior predicted by the scaling function. We also examine the finite-size scaling of the critical point and the size of the largest cluster at the critical point. This analysis leads to estimates of the critical exponent $\ensuremath{\nu}$ and the ratio of critical exponents $\ensuremath{\beta}/\ensuremath{\nu}$.

Tests of blind pedestrians’ need for detectable warning surfaces at curb ramps found that curb ramps were involved in half the cases in which there were barriers to successful crossings. In the absence of cues, some experienced travelers entered intersections at perpendicular curb ramps or were misdirected by diagonal curb ramps into parallel streets. Detectable warning surfaces provide a cue that alleviates the first problem but can exacerbate the second. Equally effective surfaces may be found that provide sufficient cues but are less expensive and easier to maintain.

Author(s): Lisa, M.A.; Albergo, S.; Bieser, F.; Brady, F.P.; Caccia, Z.; Cebra, D.A.; Chacon, A.D.; Chance, J.L.; Choi, Y.; Costa, S.; Elliott, J.B.; Gilkes, M.L.; Huager, J.A.; Hirsch, A.S.; Hjort, E.L.; Insolia, A.; Justice, M.; Keane, D.; Kintner, J.; Matis, H.S.; McMahan, M.; McParland, C.; Olson, D.L.; Partlan, M.D.; Porile, N.T.; Potenza, R.; Rai, G.; Rasmussen, J.O.; Ritter, Hans G.; Romanski, J.; Romero, J.L.; Russo, G.V.; Scharenberg, R.P.; Scott, A.; Shao, Y.; Srivastava, B.K.; Symons, T.J.M.; Tincknell, M.L.; Tuve, C.; Wang, S.; Warren, P.; Westfall, G.D.; Wieman, H.H.; Wolf, K.

We have investigated reach-through silicon avalanche diodes (AVDs) as time of flight detectors for nuclear and particle physics experiments. The signal is initiated by a minimum ionizing charged particle passing directly through the AVD. We have studied the effect of pulse amplitude and noise characteristics on timing using β − particles. The time resolution of four AVDs has been measured with a range of standard deviations, σ = 65–87 ps. This time resolution is comparable to the best available with the conventional alternative, a plastic scintillator and photomultiplier tube. Further optimization of the AVD results appears possible.

France knows advanced directives since Leonetti law which appeared in 2005. Such advanced directives help medical doctors to decide any possible withdrawing or any possible withholding. This law authorizes neither euthanasia nor assisted suicide.

À une époque où la répression de la délinquance apparaît comme un débat politique de premier plan, l'étude de la médiation pénale et de la réparation des mineurs, mesures caractéristiques de la « troisième voie » entre poursuite et classement sans suite en réaction à la commission d'une infraction, imposait d'intégrer analyse doctrinale et recherche de terrain. Le projet de recherche dont les résultats sont ici présentés, conduit avec le soutien de la Région Alsace et en partenariat avec les juridictions, parquets et barreaux alsaciens, les associations pratiquant la médiation et la réparation pénales, la Protection Judiciaire de la Jeunesse, s'est constitué autour d'une équipe de recherche composée d'étudiants de la Faculté de droit de Strasbourg, de doctorants et docteurs en droit pénal, de maîtres de conférences et professeurs d'Université. Menée à la lumière de la pratique locale récente, l'étude montre que les mesures de médiation et de réparation pénales sont de nature à apporter une réponse adaptée et durable à des situations que les voies traditionnelles ne sont pas toujours en mesure de dénouer de manière efficiente.

A systematic analysis of the multifragmentation (MF) in fully reconstructed events from 1A GeV Au, La and Kr collisions with C has been performed. This data is used to provide a definitive test of the variable volume version of the statistical multifragmentation model (SMM). A single set of SMM parameters directly determined by the data and the semi-empiricalmass formula are used after the adjustable inverse level density parameter, $\epsilon_{o}$ is determined by the fragment distributions. The results from SMM for second stage multiplicity, size of the biggest fragment and the intermediate mass fragments are in excellent agreement with the data. Multifragmentation thresholds have been obtained for all three systems using SMM prior to secondary decay. The data indicate that both thermal excitation energy $E_{th}^{*}$ and the isotope ratio temperature $T_{He-DT}$ decrease with increase in system size at the critical point. The breakup temperature obtained from SMM also shows the same trend as seen in the data. The SMM model is used to study the nature of the MF phase transition. The caloric curve for Kr exhibits back-bending (finite latent heat) while the caloric curves for Au and La are consistent with a continuous phase transition (nearly zero latent heat) and the values of the critical exponents $\tau$, $\beta$ and $\gamma$, both from data and SMM, are close to those for a 'liquid-gas' system for Au and La. We conclude that the larger Coulomb expansion energy in Au and La reduces the latent heat required for MF and changes the nature of the phase transition. Thus the Coulomb energy plays a major role in nuclear MF.

The fragment yields from the multifragmentation of gold, lanthanum and krypton nuclei obtained by the EOS Collaboration are examined in terms of Fisher's droplet formalism modifed to account for Coulomb energy. The critical exponents sigma and tau and the surface energy coefficient c0 are obtained. Estimates are made of the pressure-temperature and temperature-density coexistence curves of finite neutral nuclear matter as well as the location of the critical point., Comment: 14 pages, 13 figures, 6 tables, submitted to Phys. Rev. C

The multifragmentation data of the ISiS Collaboration and the EOS Collaboration are examined. Fisher's droplet formalism, modified to account for Coulomb energy, is used to determine the critical exponents {tau} and {sigma}, the surface energy coefficient c{sub 0}, the pressure-temperature-density coexistence curve of finite nuclear matter and the location of the critical point.

Multifragmentation MF results from 1A GeV Au on C have been compared with the Copenhagen statistical multifragmentation model ~SMM!. The complete charge, mass, and momentum reconstruction of the Au projectile was used to identify high momentum ejectiles leaving an excited remnant of mass A, charge Z, and excitation energy E* which subsequently multifragments. Measurement of the magnitude and multiplicity ~energy! dependence of the initial free volume and the breakup volume determines the variable volume parametrization of SMM. Very good agreement is obtained using SMM with the standard values of the SMM parameters. A large number of observables, including the fragment charge yield distributions, fragment multiplicity distributions, caloric curve, critical exponents, and the critical scaling function are explored in this comparison. The two stage structure of SMM is used to determine the effect of cooling of the primary hot fragments. Average fragment yields with Z>3 are essentially unaffected when the excitation energy is 170 the effective latent heat approaches zero. Thus for heavier systems this transition can be identified as a continuous thermal phase transition where a large nucleus breaks up into a number of smaller nuclei with only a minimal release of constituent nucleons. Z

J. L. Chance, F. P. Brady, J. L. Romero, S. Albergo, F. Bieser, Z. Caccia, D. Cebra, A. D. Chacon, Y. Choi,* S. Costa, J. B. Elliott, M. L. Gilkes, J. A. Hauger, A. S. Hirsch, E. L. Hjort, A. Insolia, M. Justice, D. Keane, J. C. Kintner, V. Lindenstruth, M. A. Lisa, H. S. Matis, M. McMahan, C. McParland, W. F. J. Muller, D. L. Olson, M. D. Partlan, N. T. Porile, R. Potenza, G. Rai, J. O. Rasmussen, H. G. Ritter, J. Romanski, G. V. Russo, H. Sann, R. Scharenberg, A. Scott, Y. Shao, B. K. Srivastava, T. J. M. Symons, M. Tincknell, C. Tuve, S. Wang, P. G. Warren, H. H. Wieman, T. Wienold, and K. Wolf

A systematic analysis of the moments of the fragment size distribution has been carried out for the multifragmentation of $1A\mathrm{GeV}$ Au, La, and Kr on carbon. The breakup of Au and La is consistent with a continuous thermal phase transition. The data indicate that the excitation energy per nucleon and isotopic temperature at the critical point decrease with increasing system size. This trend is attributed primarily to the increasing Coulomb energy with finite size effects playing a smaller role.

The inclusive light fragment (Z⩽7) yield data in Au+Au reactions, measured by the EOS Collaboration at the LBNL Bevalac, are presented and discussed. For peripheral collisions the measured charge distributions develop progressively according to a power law which can be fitted by a single τ exponent independently of the bombarding energy in the range 250–1200 A MeV. In addition to this universal feature, we observe that the location of the maximum in the individual yields of different charged fragments shift towards lower multiplicity as the fragment charge increases from Z=3 to Z=7. This trend is common to all six measured beam energies. Moments of charge distributions and correlations among different moments are reported. Finally, the THe,DT thermometer has been constructed for central and peripheral collisions using the double yield ratios of He and D, T projectile fragments. The measured nuclear temperatures are in agreement with experimental findings in other fragmentation reactions.

Multifragmentation in fully reconstructed events from 1A GeV Kr and La collisions with C has been studied. Results are compared with similar data for 1A GeV Au+C. The emitted charged particles and fragments are identified with emission from either a prompt first stage or a second stage in which the remnant resulting from the first stage breaks up. The nuclear charge, mass, and excitation energy distributions of the remnant are determined. The total charged multiplicity, as well as those of the first and second stages are obtained. Freeze-out temperatures and thermal excitation energy permit the determination of the caloric curve. The fragment charge distribution as well as the IMF multiplicity distribution and those of individual fragments are obtained. The various results are examined as to the extent of universal behavior when scaled for varying system size. Comparisons are made with intranuclear cascade and statistical multifragmentation model calculations. (c) 2000 The American Physical Society.

This chapter considers the value of an education in science, technology, and society studies (STS) for managers or analysts in knowledge-based industries, government, and other professions who are concerned with managing the course of technological change. By technological change, I mean intentional social innovation in the form of new tools and new ways of using them. The term “knowledge professional” is appropriate to describe these workers, because the kinds of social innovation they analyze or manage intimately involves the creation, synthesis, dissemination and application of new, science-based knowledge. (I wavered between the term “knowledge professional” and “innovation professional” to describe the workers I am discussing here. Knowledge professional seemed too broad, perhaps too closely related to the common term “knowledge worker.” It might be taken to include data entry specialists or anyone else whose occupational use of “knowledge” is passive or routine. Innovation professional seemed too narrowly focused on those who work specifically to adopt a new technology, thus omitting, for example, research program managers, research administrators and science policy analysts, all of whom I would intend to include.)

The properties of the remnant resulting from the emission of prompt particles in the interaction of 1A GeV {sup 197}Au+C interactions have been compared with intranuclear cascade and Boltzmann-Uehling-Uhlenback transport calculations. The number of first-stage particles and the energy spectra of first-stage protons are also compared. Both models can fit the general but not the detailed features of the data. (c) 1999 The American Physical Society.

It is shown that thermodynamic scaling when applied to systems with few (∼150) constituents, in accordance with the theory of critical phenomena, is observed in nuclear multifragmentation. Yields of different nuclear fragments, obtained over a wide range of excitation energies, collapse with some scatter onto a universal curve. This curve is the nuclear scaling function, which is intimately related to the free energy of the system. The determination of the scaling function forms the basis for quantitatively predicting the critical behavior in nuclei.

The mimimum requirement for a meaningful comparison of the 1 GeV Au on C data with the SMM1 predications is that the mass AR the charge Z R , and the excitation energy E x of the multifragmenting system be determined on an event by event basis. This can only be done if a full reconstruction of the collision is possible for each event. The EOS data2–4 provides a complete charge and momentum reconstruction for every event. Average fragment masses are determined. The basic remnant information A R (ZR, EX) is also used as input information for the SMM calculation. Thus a fragmentation event produced by SMM consists of M2s fragments with masses A F and charge Z F. A data fragmentation event consists of M2D fragments with mass A F and charge Z F . Since the remnant mass A R = A AU - M1 where M1 is the collisional particle multiplicity, it is convenient to introduce the total charged particle multiplicity M T for both the SMM predictions and the data. M T = M 2s + M1 for the SMM events and M T = M 2D + M1 for the Au on C events.

We supplement a recent study of the dynamics of the multifragmentation of the remnant of 1A GeV Au + C collisions by (1) providing a more complete characterization of the remnant and (2) performing a more detailed analysis of collective radial flow and exploring its consequences for the caloric curve.

Multifragmentation (MF) is the break-up of colliding nuclei into many species of lighter nuclei, particularly intermediate mass fragments (IMF’s) with 3 ≤ Z IMF ≤ 30 [1]. MF occurs in many different kinds of nuclear reactions when the excitation energy per nucleon is comparable to the nucleon binding energy. At lower excitation energy, a compound nucleus is formed, which decays by evaporation of a few light particles (primarily neutrons, protons, and alphas), leaving a large residual nucleus that contains most of the original mass. At higher energy, the excited system decomposes entirely into light particles. As excitation energy increases, the final mass yields start at low excitation with a double structure peaked at the lowest and highest masses, progress through a power law mass distribution of IMF’s at intermediate excitation, and end at high excitation with an exponential distribution of only light particles. This evolution strongly resembles the progression of a heated fluid from the liquid state through the critical point into the gaseous phase. Since pioneering studies in the early 1980’s [2], intense experimental and theoretical effort has focused on this behavior, attempting to understand the mechanism of MF. Although it is not universally accepted, the idea of a nuclear liquid-gas phase transition has become the leading paradigm used to interpret MF phenomena. Many important questions remain unresolved, including: does MF exhibited by different nuclear reactions have a common underlying physical mechanism? do the excited systems equilibrate sufficiently to apply thermal concepts? is the phase transition first order or continuous, and does this vary for different reactions? what are the thermodynamic properties (e.g. temperature, density, entropy) of these systems? what are the trajectories in the temperature-density plane for various reactions? can the physical properties of nuclear matter, including the equation of state, be extracted from MF data?

We have studied the yield of individual fragments formed in the projectile fragmentation of gold nuclei at 1 AGeV incident on a carbon target as a function of the total charge multiplicity. The yields of fragments of different nuclear charge peak at different multiplicities. We show that this behavior can be used to determine the critical exponent σ. We obtain σ = 0.68±0.05, consistent with the liquid-gas value.

The breakup of 1A GeV gold nuclei incident on carbon has been studied with a detector system that permitted exclusive event reconstruction of nearly all charged reaction products. The moments of the resulting charged fragment distribution and fluctuations therein provide strong evidence that nuclear matter possesses a critical point observable in finite nuclei. Values of the critical exponents γ, β, and τ have been determined. These values are close to those for liquid-gas systems but differ significantly from those for other 3-dimensional systems. Assumptions in our analysis have been examined and confirmed by dynamical information.

In two recent publications [1, 2], the EOS Collaboration has presented the first model independent determination of four critical exponents for nuclear matter based on the analysis of exclusive nuclear multifragmentation data obtained in 1 GeV/nucleon collisions of gold on a carbon target at the Lawrence Berkeley Bevalac. These studies were motivated in part by the striking resemblance nuclear multifragmentation data has with many aspects of critical phenomena [3, 4, 5]. In reference [2], the critical exponent σ was determined assuming that the multifragmentation data would exhibit the type of scaling expected for systems possessing critical behavior. In this paper, we demonstrate that this is indeed the case, and we determine for the first time the scaling function of nuclear matter.

Exclusive measurements have been made of Au+Au reactions with beam energies ranging from 0.25{ital A} to 1.15{ital A} GeV. We present measurements of directed collective flow averaged over all light fragments with masses up to alphas, as well as separate measurements for protons, deuterons, tritons, {sup 3}He, {sup 4}He, and Li. The results show a strong increase of the directed flow with fragment mass at all energies measured. Experimental results are compared with a quantum molecular dynamics model. We find that neither the ``soft`` nor the ``hard`` equation of state can describe the data over the entire range of beam energies.

Energy spectra of hydrogen and helium isotopes emitted in Au+Au collisions at 0.25, 0.40, 0.60, 0.80, 1.0, and 1.15 A GeV have been measured. A systematic study of the shapes of the spectra reveals a significant non-thermal component consistent with collective radial flow. The strength of this component is evaluated as a function of bombarding energy. Comparisons of the flow signal to predictions of QMD and BUU models are made. Using reverse kinematics, the breakup of gold nuclei has been studied in Au+C reactions at 1.0 A GeV. The moments of the resulting charged fragment distribution provide evidence that nuclear matter possesses a critical point observable in finite nuclei. Values for the critical exponents γ, β, and τ have been determined. These values are close to those for liquid-gas systems and different from those for 3D percolation.

We show that it is possible to extract the critical exponents from small percolation lattices. The possibility of performing a similar analysis on data from exclusive nuclear fragmentation experiments is explored.

Using charged-particle-exclusive measurements of Au+Au collisions in the LBL Bevalac`s EOS time projection chamber, we investigate momentum-space densities of fragments up to {sup 4}He as a function of fragment transverse momentum, azimuth relative to the reaction plane, rapidity, multiplicity, and beam energy. Most features of these densities above a transverse momentum threshold are consistent with momentum-space coalescence, and, in particular, the increase in sideward flow with fragment mass is generally well described by a momentum-space power law.

Experiments at the Bevalac using the Plastic Ball and streamer chamber initiated the study of nucleus-nucleus collisions with close to 4π acceptance for charged particles. [l] Much was learned as a result of these experiments, and by the mid 1980s, there was a widespread belief that it would soon be possible to constrain unambiguously the equation of state of the compressed hadron gas that exists for a few fm/c during the early stage of the collision. During the years since then, we have come to a better understanding of the difficulties involved in inferring properties of the nuclear equation of state, and while these difficulties are surmountable, there are some indications that experimental observables are less strongly influenced by the state variables of interest than was initially assumed. [2,3] Such considerations motivate new measurements with good statistics and the smallest possible observational biases.

Using reverse kinematics, we have studied the breakup of 1.0[ital A] GeV gold nuclei incident on a carbon target. The detector system permitted exclusive event reconstruction of nearly all charged reaction products. The moments of the resulting charged fragment distribution provide strong evidence that nuclear matter possesses a critical point observable in finite nuclei. We have determined values for the critical exponents [gamma], [beta], and [tau]. These values are close to those for liquid-gas systems and clearly different than those for 3D percolation and the liquid-gas mean field limit.

In a recent Rapid Communication @1#, Bauer and Botvina ~BB! presented the results of a calculation of multifragmentation ~MF! yields based on the two-step model of highenergy reactions. The first prompt step was simulated by an intranuclear cascade ~INC! and the second slower step by percolation. BB were able to adapt percolation for this purpose by the use of an ansatz that converts the excitation energy of the INC remnant, E*, into a percolation bondbreaking probability p . BB obtained results for the interaction of 1A GeV Au plus carbon for comparison with the recent data of the EOS Collaboration @2#. They find that the dependence of the second moment of the charge distribution, M 2, on the total charge multiplicity m is in fairly good agreement with the EOS data. Since percolation possesses a critical point, this agreement is consistent with our viewpoint that multifragmentation may be characterized as a critical phenomenon @2#. BB proceed to extract the critical exponents g and b from their model using a g-matching procedure that is generally similar to that used by us in the analysis of the gold MF data, although insufficient information is provided to understand their procedure in detail. It is nonetheless clear that their approach is problematic because the g-matching technique requires that the critical multiplicity mc be determined in the same fit to the data as g . BB instead use our experimental mc value in their analysis. They claim that a g match is obtained with g51.4, in agreement with experiment. We have reanalyzed the model data plotted in Fig. 2 of BB and show the results in Fig. 1. Clearly, the two lines in the figure, corresponding to the ‘‘liquid’’ and ‘‘gas’’ sides of the M 2 distribution, are not parallel. We obtain g liquid52.1 and ggas51.1, indicating that there is no g match. In contrast, Fig. 2 of Ref. @2#, which is the equivalent plot for the EOS data, shows parallel lines, indicating a g match. Evidently, the agreement between the BB calculation and the EOS data claimed by BB on the basis of their Fig. 1, with its highly compressed scale, is not so good in the log-log plot from which the exponents are extracted. The lack of a g match

the premise that this country's ability to improve and indeed maintain its present standard of living depends significantly on its ability to maintain and enhance its ability to compete in the provision of goods and services whose production requires the development and application of advanced industrial technologies. Continued attention is likely to be focused on these issues in the near future in response to growing concerns about the U.S. trade deficit and

This research built upon previous work which developed a data base for advanced terrestrial energy systems (ATES), and a computerized methodology for multiple criteria decision making (MCDM). Research determined the electric power (MEP) and facilities energy generating system (FEGS) needs. Advanced technologies have little potential to enhance FEGS operational effectiveness, but offer cost savings, especially for remote site and self sufficiency missions. MEP mission support can be enhanced by free piston systems in small sizes, by kinematic stirling and phosphoric acid fuel cells in mid sized applications (flightline, communications support) and by regenerative gas turbines in large systems. R&D programs are recommended to achieve the enhanced operational and cost potential.

The effect of labetalol on blood pressure, heart rate and the renin-angiotensin system was evaluated in 12 patients with severe essential hypertension (diastolic blood pressure greater than or equal to 120 mmHg, WHO: Phase I and II) who had been resistant to other therapeutic regimens. In 9 (76%) patients, labetalol produced a marked reduction in systolic and diastolic pressure (p less than 0.001), while the other 3 patients required the combination of high doses of the drug (1600 mg/day) with a diuretic to achieve normal blood pressure levels. The average dose which controlled blood pressure levels was 777 +/- 393 mg/day. Treatment produced a progressive decrease in heart rate. Side-effects were transient. In contrast to other beta-adrenergic blockers, treatment with labetalol did not modify plasma renin activity levels nor the total concentration of renin or inactive renin levels. During the 1-year follow-up none of the patients treated with labetalol developed cardiovascular accidents, while 4 cardiovascular events occurred in a group of 12 age-matched non-treated severely hypertensive patients. The results of this study indicate that labetalol, administered as a single therapy or in combination with a diuretic, can control blood pressure levels in severely hypertensive patients who had been resistant to the administration of other therapies. Its effects on blood pressure are not related to the renin-angiotensin system.