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In recent years, girls and young women have become particularly visible as leaders of activist campaigns and social movements. Drawing on data collected from an ACLU summer program for youth activists and advocates, this study explores the costs and benefits cisgender girls incur as a result of their activism. The findings reveal that although girls report more benefits than costs overall from their activism, the costs are correlated with the number of marginalized identities they hold. Queer Black girls report the greatest overall costs from their activism, and queer Multiracial girls report the highest rates of burnout. Queer White girls report significantly greater overall costs and problems as a result of their activism than heterosexual White girls, more burnout than heterosexual Black girls, and more empowerment than heterosexual Latinas. Informed by intersectionality and the PVEST framework, implications for supporting the sociopolitical action of girls with different social locations are discussed.

Service-learning is a high-impact practice that increases students' engagement with class material and the community. However, a critical lens is needed to strengthen students' understanding of and commitment to social justice and the inclusion of students from diverse backgrounds. This mixed method study examined the impact of a critical service-learning approach, which integrated critical curricula with 30 hours of service to community organizations, on undergraduate students' orientations towards social justice and civic engagement. Statistical analyses suggested significant differences in social dominance orientation and orientations to civic engagement across three psychology classes using critical service-learning, critical curriculum, and traditional (i.e., non-service-learning) approaches and significant differences over time in the critical service-learning class. The extent of these differences in outcomes varied between White students and students of color and between first-generation and non-first-generation students. Qualitative findings from critical service-learning students' class reflection assignments suggest that, by the end of the semester, students shifted from considering social justice as an abstract concept related to equality to identifying strategies and expressing willingness to engage in behaviors that lead to social change. This study highlights the potential for critical service-learning to enhance student learning and meet the community's needs with an awareness of power dynamics and the systemic nature of oppression. [ABSTRACT FROM AUTHOR]

Rationale: GABAA receptors containing the α5 subunit (i.e., α5GABAA receptors) appear to be critically involved in the reinforcing and subjective effects of alcohol. Their role in alcohol relapse remains unknown. Objectives: Pharmacological approaches were used to probe the role of α5GABAA receptors in alcohol seeking induced by re-exposure to a sweetened alcohol-paired cue, as well as in alcohol + sucrose vs. sucrose self-administration. Methods: For reinstatement studies, rats were trained to self-administer alcohol under a fixed-ratio schedule in which responding was maintained by alcohol + sucrose deliveries and an alcohol-paired stimulus. Sweetened alcohol seeking was extinguished by eliminating solution deliveries and the sweetened alcohol-paired stimulus. During reinstatement tests, animals received pretreatments of an α5GABAA inverse agonist (L-655,708) or an agonist (QH-ii-066) prior to sessions in which presentation of the sweetened alcohol-paired stimulus was restored, but no solution was delivered. For self-administration studies, rats were trained to self-administer alcohol + sucrose or sucrose under a fixed-ratio schedule. Once stable, animals received pretreatments of QH-ii-066, L-655,708, the inverse agonist RY-023, or naltrexone. Results: L-655,708 attenuated reinstatement of sweetened alcohol seeking by alcohol + sucrose-paired cues; whereas sweetened alcohol-seeking behavior was augmented by QH-ii-066, albeit at different doses in different rats. Both L-655,708 and RY-023 selectively reduced alcohol + sucrose vs. sucrose self-administration. In contrast, naltrexone reduced both alcohol + sucrose and sucrose self-administration; whereas QH-ii-066 enhanced sucrose self-administration only. Conclusions: α5GABAA receptors play a key role in the modulation of sweetened alcohol cue-induced reinstatement, as well as in alcohol + sucrose but not sucrose self-administration. Inverse agonist activity at α5GABAA receptors may offer a novel strategy for both the reduction of problematic drinking and the prevention of relapse. [ABSTRACT FROM AUTHOR]

The article offers information on the drugs dasatinib and panitumumab as cancer chemotherapy agents. Dasatinib is a tyrosine kinase inhibitor which competes with adenosine triphosphate for binding sites in the kinase domain of multiple targets. Panitumumab binds to epidermal growth factor receptors (EGFR) on normal and tumor cells, inhibiting the binding of ligands for EGFR.

This case report discusses dumping syndrome in the postbariatric mother. Diagnostically a challenge, the symptoms of postprandial hypoglycaemia mimic common early gestation complaints and may go undiagnosed, thus requiring a high index of suspicion. As weight-loss surgery gains traction, it is pertinent to note at booking and followups. The pregnancy is at-risk and multidisciplinary team management is central. The mainstay of management remains diet modification. There have been case reports of successful medical treatment of dumping syndrome in pregnancy with good maternal and fetal outcomes. However, more data is needed regarding the usage of these medical treatments in pregnancy.