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Background: Patients with type 2 diabetes mellitus are more prone to thyroid disorders. Hypothyroidism in them leads to an aggravation of microvascular complications. Screening for thyroid dysfunction in diabetic patients will allow early treatment of hypothyroidism. The aim of this study was to assess the prevalence of hypothyroidism in patients with type 2 diabetes mellitus and its correlation with age, HbA1c, BMI and duration of diabetes. Methods: This was a cross sectional study that was conducted at department of medicine GSVM medical college, Kanpur. 200 female patients with type 2 diabetes mellitus attending the outpatient department without any prior history of thyroid disease, chronic liver disease or acute illness were recruited for the study. Results: Our study describes 14% prevalence of hypothyroidism (subclinical hypothyroidism 13.5%) among 200 diabetic subjects. Hypothyroidism was more common in older age group maximum seen in age group 70-79 years (66.7%). Hypothyroidism was more common in subjects having diabetes for a longer duration; maximum seen in 25-30 years group (40%). No correlation was found between BMI and hypothyroidism. Conclusions: The prevalence of hypothyroidism was 14% among female patients with type 2 diabetes mellitus in this study. Overt hypothyroidism was 0.5 % and subclinical hypothyroidism was more common (13.5%) among the study subjects. Hypothyroidism was more common in older age group. and in subjects having diabetes for longer duration. No corelation was found between prevalence of hypothyroidism and body mass index (BMI).

Background: Liver disease impacts on hepatic synthesis of lipoproteins and lipogenesis but data on dyslipidemia during disease progression are limited. We want assess the patterns of dyslipidemia in with different etiology liver disease and its correlation with Child Pugh score from non-advanced (non-ACLD) advanced chronic liver disease (ACLD) as it is unclear how progression to ACLD impacts on dyslipidemia-associated cardiovascular risk. Aim and objectives of current study were to determine serum lipid profile in patients with chronic liver disease and its correlation with Child Pugh score. Methods: It was Cross sectional, observational study conducted in 200 patients at KPS post graduate institute of medicine, GSVM medical college, Kanpur from December 2020 to October 2022. Results: In this study mean value of Serum Cholesterol (mg/dl) was 135.25 (27.88), Serum Triglycerides (mg/dl) was 122.27 (36.29), HDL Cholesterol was 46.92 (10.36), LDL Cholesterol was 62.77 (22.59), VLDL Cholesterol was 25.62 (8.71). In this study maximum patients of chronic liver disease were due to chronic alcohol intake which account for 76% patients, 2nd most common aetiology of chronic liver disease were chronic viral hepatitis and rest were due to Wilson disease, Budd Chiari syndrome non cirrhotic portal fibrosis and cryptogenic. Patients of chronic liver disease have negative correlation on lipid profile with Child Pugh score. Conclusions: From our study its was concluded that patients having higher CTP score having more derangement (low) in serum lipid profile (specially) serum cholesterol, serum HDL, serum VLDL) than the patients having low CTP score.

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BackgroundRecent evidences suggested that deficiency of Vit-D is associated with risk of ischemic stroke and its severity. The mechanism behind its relationship have been linked to total oxidant level and some other modifiable risk factor like hypertension, diabetes, smoking and alcohol consumption and tobacco chewing. However, there are disappearances in evidences. The aim of this study is to find out the role of Vit-D and Total oxidants in ischemic stroke and in disease progression.MethodsIn this case control study total 205 individuals of case and control enrolled in this study the demographic data like age, gender, ethnicity, dietary habit, addiction (smoking, alcohol, tobacco chewing) previous history of disease (hypertension, diabetes, any cardiovascular disease) were collected from family members and other medical record. ResultsThe mean age of case and control group of 63.91 ± 12.66 and 62.52 ± 7.04 respectively. There was significant difference between insufficient Vit-D level in case and control group (p

Background: Type 2 diabetes mellitus (T2DM) is a multifactorial, complex disease associated with chronic hyperglycemia, resulting from the interplay of genetic, environmental, and epigenetic factors. T2DM can causes various disabling complications. Diabetic autonomic neuropathy (DAN) is one of the common complications in diabetes. The taste threshold affected by various factors such as age, ethnic backgrounds, drugs, local and systemic diseases, consumption of alcohol, smoking, and tobacco chewing.Method: The present study is undertaken with the objectives to compare the taste dysfunction of four primary sensations in Type 2 DM with autonomic neuropathy and its relation with glycemic control. The 60 patients of T2DM with autonomic neuropathy and 60 healthy controls were taken for the study. Autonomic neuropathy was assessed clinically. Chemical taste test using four solutions of basic tastes (sweet, sour, salty, bitter) were done.Results: Taste dysfunction for sweet was significant in T2DM with uncontrolled hyperglycemia. The taste dysfunction in T2DM patients was not related to gender, disease duration, and type of treatment taken. The study found a significant correlation between taste dysfunction, HbA1C level and blood sugar fasting level in T2DM patients.Conclusions: The taste dysfunction was mainly for sweet. Sour and bitter did not show any difference in case groups compared to controls.