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One of the main opportunistic fungal infections amongst immunocompromised individuals is oral candidosis, which has been found in up to 90% of human immunodeficiency virus (HIV)-infected patients. This study employed yeasts isolated from the saliva and oral cavities of 114 HIV-infected patients living in Campinas, São Paulo. Of the isolates, 57.8% were identified as Candida albicans and 42.1% as non-C. albicans. The latter isolates were subsequently identified as C. krusei (7.5%), C. lusitaniae (5.2%), C. tropicalis (4.6%), C. parapsilosis (4.6%), C. glabrata (2.8%), C. kefyr (1.7%), C. guilliermondii (1.7%), C. intermedia (1.1%), C. norvegensis (0.5%), and Rhodotorula rubra (1.7%). Susceptibility of the isolates to amphotericin B, fluconazole, miconazole, and itraconazole was also determined by a microdilution method adopted by the National Committee for Clinical Laboratory Standards. The isolates demonstrated various susceptibilities to the antifungal agents. In particular 29 C. albicans and 13 non-C. albicans isolates showed low susceptibility to FLCZ (> 64 µg/ml). This study revealed huge diversity of Candida species, in particular the increasing emergence of non-C. albicans associated with the oral flora of HIV-infected patients.

The sharing economy (SE) is a nascent phenomenon representing a socio-economic process to optimise underutilised resources through digital platforms. This process facilitates the shared consumption of resources to maximise resource utilisation while supporting the circularity of resources. However, the successful operation of SE practices is hindered by the lack of identification of effective strategies for enhancing the SE implications, which are essential to comprehending SE practices and developing more sophisticated applications. Therefore, this research aims to provide the first insights into the strategies that enhance SE practices across diverse industries and identify knowledge gaps and future research directions. A systematic literature review (SLR) was conducted by selecting articles published in the 2014–2023 period in Scopus and Web of Science databases. Selected articles were subjected to descriptive and NVivo 14-supported thematic analyses. The descriptive analysis showed that, despite considering articles published in the last 10 years, all relevant articles were published in the last 5 years. Developed and developing countries showed almost equal contributions, while China was recognised as the country with the highest number of publications. Accommodation and transportation sectors were reported as the sectors with the highest number of publications. A cross-analysis was conducted to recognise the varying utilisation of different strategies across diverse industries and sectors. Ten different categories were identified through the thematic analysis that enhance SE practices: economic; environmental; geographic; governance; health, safety, and security; marketing; people; product/services; research, training, education; and technology-related strategies. Each category was discussed along with its relevant strategies, resulting in identifying a total of 84 strategies. These strategies were then presented alongside the responsible parties tasked with their implementation. The study contributes to the SE literature by providing an SLR for contemporary strategies utilised to enhance SE practices, specifically focusing on elucidating the most appropriate categorisation of these strategies. Moreover, this comprehensive SLR provides the first insights into the effective strategies that enhance SE practices across diverse industries. [ABSTRACT FROM AUTHOR]

Background: Pain secondary to chemotherapy-induced peripheral neuropathy (CIPN) can limit the administration of chemotherapy, cancer-treatment outcomes, and the quality of life of patients. Oxidative stress and inflammation are some of the key mechanisms involved in CIPN. Successful treatments for CIPN are limited. This report shows our preliminary experience using ozone treatment as a modulator of oxidative stress in chronic pain secondary to CIPN.Methods: Ozone treatment, by rectal insufflation, was administered in seven patients suffering from pain secondary to grade II or III CIPN. Pain was assessed by the visual analog scale (VAS).Results: All patients, except one, showed clinically relevant pain improvement. Median pain score according to the VAS was 7 (range: 5–8) before ozone treatment, 4 (range: 2–6) at the end of ozone treatment (p = 0.004), 5.5 (range: 1.8–6.3) 3 months after the end of ozone treatment (p = 0.008), and 6 (range: 2.6–6.6) 6 months after the end of ozone treatment (p = 0.008). The toxicity grade, according to the Common Terminology Criteria for Adverse Events (CTCAE v.5.0), improved in half of the patients.Conclusion: This report shows that most patients obtained clinically relevant and long-lasting improvement in chronic pain secondary to CIPN after treatment with ozone. These observed effects merit further research and support our ongoing randomized clinical trial (NCT04299893).

Urbanisation has been one of the most transformative processes of our time, and in recent decades has led to significant changes in the way we live, work, and interact with the world around us [...]

Cities are the engines of economic growth, but they are also the source of many environmental and social challenges [...]

We have developed a simple photogrammetric method to identify heterogeneous areas of irrigated olive groves and vineyard crops using a commercial multispectral camera mounted on an unmanned aerial vehicle (UAV). By comparing NDVI, GNDVI, SAVI, and NDRE vegetation indices, we find that the latter shows irrigation irregularities in an olive grove not discernible with the other indices. This may render the NDRE as particularly useful to identify growth inhomogeneities in crops. Given the fact that few satellite detectors are sensible in the red-edge (RE) band and none with the spatial resolution offered by UAVs, this finding has the potential of turning UAVs into a local farmer’s favourite aid tool.