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1. Computer Aided Orthopaedic Surgery: Incremental shift or paradigm change?

Author: Leo Joskowicz and Eric J. Hazan
Published: 2016
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2. 1050 DELIRIUM RECOGNITION AND MANAGEMENT IN AN INPATIENT REHABILITATION UNIT

Author: I Stoodley, R Kyzy, null Conroy, J McKenzie, S Geen, J Asino, E Cruz, and J Hazan
Subjects: Aging, General Medicine, Geriatrics and Gerontology
Abstract: Introduction Delirium is associated with poor outcomes, but is under-diagnosed and under-treated. This project aimed to improve delirium recognition and multidisciplinary team (MDT) management on an inpatient rehabilitation ward. (NICE delirium: prevention, diagnosis and management, 2010). Methodology Using the Model for Improvement, the MDT identified four areas of delirium care; prevention, recognition, causes and management. Aspects of each were mapped in a driver diagram. The MDT voted on areas to target. Results and interventions were reviewed at weekly meetings. PDSA cycles 1.A delirium marker was introduced to the nursing handover and patients’ rooms. Data was collected on its use and weekly MDT meetings were used to check the accuracy of delirium identification. 2.An audit was completed of the 'patient profile’ information held in patients' bedside files. A person-centred ‘about me’ board was introduced instead and positioned visibly in patients’ rooms. 3.Healthcare assistants completed daily bowel charts. 4.Doctors completed anticholinergic medication reviews. Data was analysed using SPC charts. Results Before the delirium flag 0% of patients with delirium were identified on nursing handover. This improved to 58% on average, although some patients were incorrectly identified as delirious. Baseline personal profile completion rate was 61% on average, but the information quality collected was poor. The new ‘about me’ profile completion rate improved over time, varying between 16% and 86%. 100% of patients had medication reviews. Bowel chart completion improved from 89% to 100%. Conclusion Recognition of delirium improved. Stool charts and medication reviews were successfully implemented. The ‘about me’ board completion rate fluctuated but the information is now more visible. Our long-term goal is to improve patient-related outcomes such as engagement in therapy quality of life, and length of stay. Teaching sessions on delirium will be delivered by MDT members. Successful interventions will be expanded to other wards and PDSA cycles will continue.
Published: 2022
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3. Microcalcifications Detected as an Abnormality on Screening Mammography: Outcomes and Followup over a Five-Year Period

Author: Melissa Craft, Anne M. Bicknell, Georges J. Hazan, and Karen M. Flegg
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Objectives. This study reviewed the outcome of women attending a breast screening program recalled for assessment of microcalcifications and examined the incidence of a breast carcinoma detected during the following five years in any of the women who were given a benign diagnosis at assessment. Method. A retrospective study consisted of 235 clients attending an Australian BreastScreen program in 2003, who were recalled for investigation of microcalcifications detected on screening mammography. Records for the following five years were available for 168 women in the benign outcome group including those who did not require biopsy at initial assessment. Results. Malignant disease was detected in 26.0% (n=146) of the women who underwent biopsy. None of the women in the benign outcome group, with available five-year follow-up records, developed a subsequent breast cancer, arising from the calcifications initially recalled in 2003. Conclusions. This study highlights the effectiveness of an Australian screening program in diagnosing malignancy in women with screen detected microcalcification. This has been achieved by correctly determining 38% (n=235) of the women as benign without the need for biopsy or early recall. A low rate of open surgical biopsies was performed with no cancer diagnoses missed at the time of initial assessment.
Published: 2013
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4. Corrosion and Protection (Conversion Coating and Plasma Electrolytic Oxidation) of Ti6Al4V Processed by Powder Bed Fusion—Additive Manufacturing. EIS Study

Author: J. Hazan and M. Bamberger
Subjects: chemistry.chemical_compound, Materials science, chemistry, Chemical engineering, Anodizing, Conversion coating, Permanganate, chemistry.chemical_element, Plasma electrolytic oxidation, Electrochemistry, Corrosion, Dielectric spectroscopy, Titanium
Abstract: Green conversion coatings have been developed using oxyanion like permanganate additive (a conversion layer former) to an acidic medium (H2SO4). Reduction products of permanganate, mainly MnO2, occur due to the high standard reduction potential (Ered0 = 1.695 V) for the electrochemical reaction in acid solution. An anodic oxide film by anodization (plasma electrolytic oxidation) has been also performed. The structure obtained for these two protective coatings consists of an outer (porous) layer, observed at high frequencies, and an inner (barrier) layer, at low frequencies in the impedance diagram. An electrical equivalent circuit describing the coated alloy is proposed. Electrochemical corrosion results in the corroding electrolyte (NaCl 3%) of Ti6Al4V will be presented and compared to that of a rolled (Ti–0.15% Pd) foil. Finally, semiconductive properties of the passive film formed on the additive manufactured titanium alloy have been investigated. TiO2−α is an n-type semiconductor having oxygen deficiency that provokes significant change in the electrical conductivity. Mott–Schottky plots (CSC−2 vs. E) have been drawn, and the donor concentration ND has been determined from the linear part.
Published: 2020
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5. Semi-integral LOCA test of cold-spray chromium coated zircaloy-4 accident tolerant fuel cladding

Author: E. Pouillier, J. Hazan, Koroush Shirvan, and A. Gauthier
Subjects: Nuclear and High Energy Physics, Materials science, Nuclear engineering, Zirconium alloy, Gas dynamic cold spray, Evolutionary change, chemistry.chemical_element, Cladding (fiber optics), law.invention, Chromium, Fukushima daiichi, Nuclear Energy and Engineering, chemistry, law, Nuclear power plant, General Materials Science, Loss-of-coolant accident
Abstract: Enhancing the accident tolerance of PWRs came under serious consideration following the 2011 Fukushima Daiichi nuclear power plant events. While the current nuclear fuels are based on mature technology and have an excellent operational record, further enhancing their strength through accident tolerant fuel (ATF) research and development continues to be of interest. Particularly, the chromium coated clad ATF technology represents an evolutionary change to improve the high temperature performance of existing Zircaloy claddings. Despite several years of investigation of coated cladding, the integral loss of coolant accident (LOCA) performance of chromium coated cladding has had little attention. In this work, cold-spray chromium coated zircaloy-4 claddings are evaluated using EDF's semi-integral LOCA test facility. Results show that the chromium coating induces a reduced ballooning and burst and an increased burst temperature in the investigated conditions. However, these tests exhibit limited benefits concerning the post-quench behavior of the coated specimens which occurs in the last stage of a prototypical LOCA scenario.
Published: 2021
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6. Computer-Aided Orthopedic Surgery: Incremental Shift or Paradigm Change?

Author: Leo, Joskowicz and Eric J, Hazan
Subjects: Radiography, Orthopedics, Surgery, Computer-Assisted, Humans, Arthroplasty, Replacement, Knee
Abstract: Computer-aided orthopedic surgery (CAOS) is now about 25 years old. Unlike neurosurgery, computer-aided surgery has not become the standard of care in orthopedic surgery. In this paper, we provide the technical and clinical context raised by this observation in an attempt to elucidate the reasons for this state of affairs. We start with a brief outline of the history of CAOS, review the main CAOS technologies, and describe how they are evaluated. We then identify some of the current publications in the field and present the opposing views on their clinical impact and their acceptance by the orthopedic community worldwide. We focus on total knee replacement surgery as a case study and present current clinical results and contrasting opinions on CAOS technologies. We then discuss the challenges and opportunities for research in medical image analysis in CAOS and in musculoskeletal radiology. We conclude with a suggestion that while CAOS acceptance may be more moderate than that of other fields in surgery, it still has a place in the arsenal of useful tools available to orthopedic surgeons.
Published: 2018

7. Computer-Aided Orthopedic Surgery: Incremental Shift or Paradigm Change?

Author: Leo Joskowicz and Eric J. Hazan
Subjects: 030222 orthopedics, medicine.medical_specialty, Standard of care, Context (language use), Total knee replacement surgery, 03 medical and health sciences, 0302 clinical medicine, Image-guided surgery, Paradigm shift, Orthopedic surgery, Computer-aided, medicine, Medical physics, Neurosurgery, Psychology, 030217 neurology & neurosurgery
Abstract: Computer-aided orthopedic surgery (CAOS) is now about 25 years old. Unlike neurosurgery, computer-aided surgery has not become the standard of care in orthopedic surgery. In this paper, we provide the technical and clinical context raised by this observation in an attempt to elucidate the reasons for this state of affairs. We start with a brief outline of the history of CAOS, review the main CAOS technologies, and describe how they are evaluated. We then identify some of the current publications in the field and present the opposing views on their clinical impact and their acceptance by the orthopedic community worldwide. We focus on total knee replacement surgery as a case study and present current clinical results and contrasting opinions on CAOS technologies. We then discuss the challenges and opportunities for research in medical image analysis in CAOS and in musculoskeletal radiology. We conclude with a suggestion that while CAOS acceptance may be more moderate than that of other fields in surgery, it still has a place in the arsenal of useful tools available to orthopedic surgeons.
Published: 2018
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8. Corrosion behaviour of Sn-containing oxide layer on AZ91D alloy formed by plasma electrolytic oxidation

Author: C.-E. Barchiche, Emmanuel Rocca, and J. Hazan
Subjects: Materials science, Passivation, Anodizing, Magnesium, Metallurgy, Alloy, technology, industry, and agriculture, Oxide, chemistry.chemical_element, Surfaces and Interfaces, General Chemistry, engineering.material, Plasma electrolytic oxidation, equipment and supplies, Condensed Matter Physics, Surfaces, Coatings and Films, Corrosion, chemistry.chemical_compound, chemistry, Materials Chemistry, engineering, Magnesium alloy
Abstract: Corrosion phenomenon of magnesium alloys is one of the limits for using magnesium alloys in automotive and aerospace industries. The aim of this study is the development of Sn-containing protective oxide coating by a simple plasma electrolytic oxidation in KOH/KF/Na3PO4 electrolyte on AZ91D magnesium alloy in galvanostatic mode. The film morphology and composition were analysed by SEM coupled with EDS, XRD and Raman spectroscopy. In the oxide, tin is mainly incorporated as crystallised MgSn(OH)6 compound in the layer. The main properties of Sn-containing oxide coating on AZ91D are both keeping the corrosion rate at open-circuit conditions at an acceptable value, and providing a sufficient passivation plateau to reduce the pitting sensibility. The lather characteristic, revealed by pitting tests, addresses the major drawback of magnesium alloys which often undergo important galvanic coupling in service. Consequently, the addition of low stannate concentration in the electrolyte to form Sn-rich anodic oxide on magnesium alloys represents an interesting way to synthesize protective coatings by PEO in a short time of anodization.
Published: 2008
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9. Corrosion resistance of plasma-anodized AZ91D magnesium alloy by electrochemical methods

Author: J. Hazan, C.-E. Barchiche, J. Steinmetz, C. Juers, and Emmanuel Rocca
Subjects: Materials science, Passivation, Anodizing, Magnesium, General Chemical Engineering, Metallurgy, Alloy, chemistry.chemical_element, Electrolyte, engineering.material, Corrosion, Dielectric spectroscopy, Chemical engineering, chemistry, Electrochemistry, engineering, Magnesium alloy
Abstract: Anodic coatings formed on magnesium alloys by plasma anodization process are mainly used as protective coatings against corrosion. The effects of KOH concentration, anodization time and current density on properties of anodic layers formed on AZ91D magnesium alloy were investigated to obtain coatings with improved corrosion behaviour. The coatings were characterized by scanning electron microscopy (SEM), electron dispersion X-ray spectroscopy (EDX), X-ray diffraction (XRD) and micro-Raman spectroscopy. The film is porous and cracked, mainly composed of magnesium oxide (MgO), but contains all the elements present in the electrolyte and alloy. The corrosion behaviour of anodized Mg alloy was examined by using stationary and dynamic electrochemical techniques in corrosive water. The best corrosion resistance measured by electrochemical methods is obtained in the more concentrated electrolyte 3 M KOH + 0.5 M KF + 0.25 M Na 3 PO 4 ·12 H 2 O, with a long anodization time and a low current density. A double electrochemical effects of the anodized layer on the magnesium corrosion is observed: a large inhibition of the cathodic process and a stabilization of a large passivation plateau.
Published: 2007
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10. Computer-Assisted Image-Guided Intramedullary Nailing of Femoral Shaft Fractures

Author: Leo Joskowicz and Eric J. Hazan
Subjects: Surgical team, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Femoral shaft, Femoral Shaft Fracture, medicine.medical_treatment, Fracture site, law.invention, Surgery, Intramedullary rod, law, Medicine, Fluoroscopy, Orthopedics and Sports Medicine, business, Range of motion, Reduction (orthopedic surgery)
Abstract: Summary: Closed reduction and intramedullary nailing under x-ray fluoroscopy is the current treatment of choice for femoral shaft fractures. However, many images are required to successfully perform the procedure, especially for distal locking of the nail, resulting in cumulative radiation exposure to the surgeon. Recently, computer-based technologies have been developed for surgical navigation, enabling the surgeon to accurately track in real-time the instruments, implants, and patient anatomy during a procedure. This article reviews the principles and potential benefits of computer-aided image-guided surgery for femoral shaft fracture, its indications, and its pitfalls. The existing systems, commercially available and prototypes, and the early clinical experience using this technique are also briefly discussed. Key Words: Computer-assisted orthopaedic surgery—Image-guided surgery—Femur fracture—Intramedullary nailing. Femoral shaft fractures are best treated with interlocked intramedullary nailing, providing stable fixation to maintain longitudinal and rotational alignment to allow early active range of motion. 2 The introduction of image intensifiers in the operating room has enabled the surgeon to perform both the reduction and stabilization without opening the fracture site, reducing further damage to the traumatized area and maximizing its biologic potential for healing. Closed antegrade nailing is a minimal exposure surgery and is currently the treatment of choice for femoral shaft fractures. 26 However, a great number of fluoroscopic images are required in each step of the procedure to achieve successful anatomic reduction and stable fixation, resulting in cumulative radiation exposure to the surgeon, the surgical team, and the patient. 14 Limitations from this technique arise because
Published: 2003
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11. Computer-Assisted Orthopaedic Surgery

Author: Eric J. Hazan
Subjects: medicine.medical_specialty, business.industry, Orthopedic surgery, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, medicine, Medical imaging, Orthopedics and Sports Medicine, Medical physics, Virtual reality, business, Field (computer science)
Abstract: SummaryOrthopaedic surgery has benefited from significant progress in surgical techniques and implants through advances in technology and science. Recent developments integrating medical imaging and spatial tracking technologies open an entirely new field. A virtual reality image allows the surgeon
Published: 2003
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12. Experimental model for allograft incorporation and allograft fracture repair

Author: Henry J. Mankin, Mark C. Gebhardt, Eric J. Hazan, and Francis Young-In Lee
Subjects: medicine.medical_specialty, medicine.medical_treatment, Osteotomy, law.invention, Rats, Sprague-Dawley, Intramedullary rod, law, medicine, Animals, Transplantation, Homologous, Orthopedics and Sports Medicine, Femur, Kirschner wire, Endochondral ossification, Fracture Healing, Periosteum, business.industry, Anatomy, Fracture Fixation, Intramedullary, Rats, Surgery, Diaphysis, medicine.anatomical_structure, Rats, Inbred Lew, Intramembranous ossification, business
Abstract: This study describes a rat model of allograft osteotomy healing. An intercalary skeletal defect was created in adult Lewis rats by resecting a 2-cm segment of the femur in the diaphysis, including the periosteum and the cuff of muscle layers. The skeletal defects were replaced with fresh-frozen devascularized intercalary allografts from Sprague-Dawley rats. A transverse osteotomy was made in the middle of the allograft. The osteotomized segments were stabilized with an intramedullary threaded Kirschner wire, which allowed immediate ambulation. Radiographic and histological examination at 4 and 8 weeks revealed a characteristic healing process at three different interfaces. Radiographically, the distal metaphyseal host-donor junction healed faster than the proximal diaphyseal host-donor interface. The osteotomy site did not have evidence of an intramembranous or endochondral repair process. This model can serve as a baseline for assessing allograft incorporation and fracture repair.
Published: 2000
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13. Recurrent Giant-Cell Tumor Presenting as a Soft-Tissue Mass. A Report of Four Cases*

Author: Susan V. Kattapuram, Francis Young-In Lee, Eric J. Hazan, Suzanne B. Keel, Mark L. Montgomery, and Henry J. Mankin
Subjects: medicine.medical_specialty, medicine.diagnostic_test, Ossification, business.industry, medicine.medical_treatment, Long bone, Soft tissue, Physical examination, Magnetic resonance imaging, General Medicine, Asymptomatic, Curettage, Surgery, medicine.anatomical_structure, Pathognomonic, medicine, Orthopedics and Sports Medicine, medicine.symptom, business
Abstract: Giant-cell tumor of bone is a benign, locally invasive tumor that has been associated with a rate of local recurrence of 27 percent (forty-one of 151) after intralesional excision and 8 percent (ten of 122) after marginal excision1. The high rate of local recurrence and the occasional development of pulmonary metastasis are manifestations of the locally invasive nature of the tumor4-6,8,9,11,12. A peripheral rim of ossification has been described as an almost pathognomonic sign of a soft-tissue recurrence2,3,11. However, a soft-tissue recurrence can be difficult to detect, especially when the recurrent lesion is asymptomatic and is not associated with the characteristic ossification. We report on four patients who had an isolated soft-tissue recurrence of a giant-cell tumor of bone. Although a radiodense peripheral rim of ossification is thought to be pathognomonic of a soft-tissue recurrence of giant-cell tumor, this finding was not apparent on the plain radiographs of any of these patients. In each case, a soft-tissue mass was palpable on physical examination and magnetic resonance imaging scans revealed a soft-tissue mass with a heterogeneous signal pattern. The purpose of this report is to emphasize that a soft-tissue recurrence may not be recognized if a thorough physical examination is not performed and magnetic resonance imaging studies are not carried out. CASE 1. A forty-two-year-old woman was seen by us because of a rapidly enlarging soft-tissue mass in the posteromedial aspect of the proximal part of the right calf. Twenty-six months previously, the patient had been managed with curettage and bone-grafting because of a giant-cell tumor of the proximal aspect of the right tibia. Six months after the initial treatment, the patient had a recurrence of the giant-cell tumor and was …
Published: 1999
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14. Corrosion Behaviour in Low Concentrated Sulfate Solution of Thermal Spray (HVOF) Zinc Coatings on Steel

Author: Christian Coddet and J. Hazan
Subjects: Materials science, Mechanical Engineering, Metallurgy, chemistry.chemical_element, Zinc, engineering.material, Condensed Matter Physics, Emery paper, Corrosion, Thermal barrier coating, Coating, chemistry, Mechanics of Materials, Aluminium, engineering, General Materials Science, Nyquist plot, Thermal spraying
Abstract: The aim of this work was to evaluate the corrosion behavior of (HVOF) thermally sprayed zinc coatings on steel as compared to plain zinc and to zinc coatings obtained by other techniques. The study was perfomed in a low conductive dilute solution of potassium sulfate (0.01 M). This electrolyte has been chosen recently to give us a better tool in order to control the rugosity of zinc surfaces after mechanical polishing with emery paper of different sizes and to evaluate the porosity of chromated zinc coatings. The purpose in this case is to determine the porosity using measurements in a wide range of frequencies by the relative variation of the resistivity of unchromated and chromated zinc coatings. The determined impedance parameters have been found to be very different for the thermal spray zinc coating in comparison to the other zinc samples. As the charge transfer resistance R t in inversely proportional to the effective surface, the decrease in its value for the thermal coating can be explained by the increase of the active surface. The depression angle in the Nyquist plot for the high frequency loop has also been determined for all the systems and the difference found may be interpreted in terms of the physical properties of the different surfaces. The sacrificial protective characteristics of these coatings towards steel and the results obtained when aluminium was added to zinc by plasma - HVOF and other techniques in order to fabricate a less effective cathode especially towards oxygen reduction will be discussed.
Published: 1998
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15. Corrosion du zinc dans un milieu alcalin: Effet d'un traitement de passivation chromique

Author: J. Hazan and C. Comet
Subjects: Chromate conversion coating, Passivation, Chemistry, General Chemical Engineering, Materials Chemistry, Electrochemistry, chemistry.chemical_element, Zinc, Corrosion, Nuclear chemistry
Abstract: Cette communication presents des resultats obtenus concernant la corrosion dans un milieu alcalin du zinc passive dans une solution chromique phosphorique, traitement servant notamment a augmenter la resistance a la corrosion du zinc a l'empilage humide. A titre de reference, le comportement du zinc pur Bans le meme environnement a aussiete considere. L'accent dans cette etude est mis sur l'application de techniques electrochimiques notamment de trace de courbes de polarisation et de diagrammes d'impedance. Les effets du temps d'immersion, de (agitation, de la rotation du disque et d'une polarisation cathodique prealable sont interpretes.
Published: 1996
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16. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain

Author: H. Hattig, C. Delli Pizzi, M. C. Addonizio, Michelle Davis, A. R. Giovagnoli, L. Florensa, M. Roth, J. de Kruijk, Francisco Lacruz, Ph. Dewailly, A. Toygar, C. Avendano, P.P. De Deyn, J. F. Hurtevent, F. Lomeila, T. W. Wong, Gordon T. Plant, M. Bud, H. J. Willison, DH Miller, D. W. Langdon, R. Cioni, J. Servan, A. Kaygisiz, E. Racadot, D. B. Schens, E. Picciola, L. Falip, C. Bouchard, J. Jotova, A. Jorge-Santamaria, P. Misra, A. Dufour, C. P. Panagopoulos, A. Venneri, B. Sredni, B. Angelard, M. Janelidze, M. Carreno, J. Obenberger, J. Pouget, H. W. Moser, R. Kaufmann, J. A. Molina, D. Linden, A. Martin Urda, E. Uvestad, A. Krone, J. P. Cochin, J. Mallecourt, A. Cambon-Thomsen, K. Violleau, P. Osschmann, A. M. Durocher, E. Bussaglia, D. M. Danielle, H. Efendi, C. Van Broeckhoven, K. G. Jordan, W. Rautenberg, C. Iniguez, J. M. Delgado, Graham Watson, M. Lawden, Gareth J. Barker, K. Stiasny, James T. Becker, G. Campanella, E. Peghi, A. Poli, A. Haddad, T. Yamawaki, Giacomo P. Comi, S. Sotgiu, B. Ersmark, A. Pomes, M. Ziegler, P. Ferrante, P. Ruppi, H. KuÇukoglu, R. Bouton, U. K. Rinne, P. Vieregge, M. Dary, P. Giunti, Peter J. Goadsby, S. Jung, E. Secor, A. Steinberg, N. Vila, M. A. Hernandez, M. Cursi, A. Enqelhardt, A. Engelhardt, J. Veitch, F. Di Silverio, F. Arnaud, B. Neundörfer, R. Brucher, Dominique Caparros-Lefebvre, B. Meyer, Marianne Dieterich, M. H. Snidaro, R. Gomez, R. Cerbo, M. Ragno, J. M. Vance, S. Nemni, A. Caliskan, F. Barros, I. Velcheva, D. Ceballos-Baumann, V. Barak, A. Avila, N. Antonova, F. Resche, S. Pappata, L. Varela, S. R. Silveira Santos, A. Cammarota, L. Naccache, Y. Nara, E. Tournier-Lasserves, R. Mobner, T. Chase, A. Ensenyat, J. Ulrich, G. Giegerich, M. Rother, M. Revilla, N. Nitschke, K. Honczarenko, E. Basart Tarrats, J. Blin, B. Jacob, J. Santamaria, S. Knezevic, J. L. Castillo, M. Antem, J. Colomer, O. Busse, Didier Hannequin, S. Carrier, J. B. Ruidavets, C. Rozman, J. Bogoussslavsky, J. Pascual Calvet, E. Monros, J. M. Polo, M. Zucconl, Javier Muruzabal, R. R. Allen, R. Rivolta, K. Haugaard, A. Nespolo, K. Hoang-Xuang, G. Bussone, T. Avramidis, E. Corsini, Christiana Franke, T. Vinogradova, H. Boot, K. Vestergaard, G. H. Jansen, N. Argentino, M. Raltzig, W. Linssen, Mark B. Pepys, P. Roblot, L. Lauritzen, E. Fainardi, D. Morin, T. X. Arbizu Urdiain, J. Wollenhaupt, S. Bostantjopoulou, G. Pavesi, A. D. Forman, Giovanni Fabbrini, D. Jean, J. J. Archelos, M. I. Blanchs, M. Del Gobbo, Anna Carla Turconi, Ch. Derouesné, Elio Scarpini, A. Visbeck, P. Castejon, J. P. Renou, F. Mounier-Vehier, G. Potagas, Ch. Duyckaerts, A. Filla, R. Schneider, G. Ronen, K. Nagata, J. P. Vedel, A. Henneberg, G. van Melle, C. Baratti, H. Knott, M. C. Prevett, A. Bes, B. Metin, Jos V. Reempts, L. Martorell, Mefkure Eraksoy, H. O. Handwerker, D. S. Younger, O. Oktem, D. Frongillo, C. Soriano-Soriano, L. Niehaus, F. Zipp, A. Tartaro, S Newman, R. H. Browne, P. Davous, R. Sanchez, M. Muros, M. E. Kornhuber, A. Lavarone, M. Mohr, M. R. Garcia, S. Russell, H. Kellar-Wood, M. R. Tola, B. Ostermeyer, Ch. Tzekov, K. Sartor, E. B. Ringelstein, P. P. Gazzaniga, Paul Krack, H. Fidaner, H. Rico, T. Dbaiss, F. Alameda, E. Torchiana, L. Rumbach, I. Charques, J. M. Bogaard, C. D. Frith, L. J. Rappelle, R. Brenner, A. Joutel, K. Fuxe, G. HÄcker, M. J. Blaser, J. Valls-SolÇ, G. Ulm, M. Alberdi, A. Bock, F. W. Bertelsmann, U. Wieshmann, J. Visa, J. R. Lupski, D. D'Amico, L. M. P. Ramos, A. A. Vanderbark, R. Horn, M. Warmuth, Dietmar Kühne, Mark S. Palmer, C. Ehrenheim, E. Canga, S. Viola, O. Scarpino, P. Naldi, R. Almeida, A. A. Raymond, J. Gamez, Stephan Arnold, A. DiGiovanni, J. Dalmau, C. C. Chari, H. F. Beer, J. C. Koetsier, J. Iriarte, E. Yunis, J. Casadevall, E. Le Guern, E. Stenager, S. R. Benbadis, J. M. Warter, F. Burklin, I. Theodorou, L. Johannesen, G. A. Graveland, X. Leclerc, I. Vecchio, L. Ozelius, G. Nicoletti, R. K. Gherardi, E. Esperet, M. L. Delodovici, F. Cattin, F. Paiau, Giorgio Sacilotto, C. A. J. Broere, D. Chavdarov, J. P. Willmer, C. H. Hawkes, Th. Naegele, E. Ellie, E. Dartigues, M. J. Guardiola, S. Hesse, Z. Levic, Marco Rovaris, P. Saugeir-Veber, B. A. Yaqub, H. F. Durwen, R. Larumbe, J. Ballabrina, M. Sendtner, J. Röther, M. Horstink, C. Kluglein, M.P. Montesi, H. Apaydin, J. Montoya, E. Waubant, Ch. Verellen-Dunoulin, A. Nicolai, J. Lopez-Delval, R. Lemon, G. Cantinho, E. Granieri, A. Zeviani, Wolfgang H. Oertel, U. Ficola, V. Di Piero, V. Fragola, K. Sabev, M. V. Guitera, I. Turki, F. Bolgert, P. Ingrand, J. M. Gobernado, L. M. E. Grimaldi, S. Baybas, B. Eymard, Y. Rolland, Y. Robitaille, Ta. Pampols, P. J. Koehler, A. Carroacedo, J. Vilchez, S. Di Vittorio, I. R. Rise, T. Nagy, M. Kuffner, E. Palazzini, A. Ott, J. Pruim, T. X. Arbizu, E. Manetti, C. Cervera, S. Felber, G. Gursoy, J. Scholz, G. A. Buscaino, M. S. Chen, A. Pascual, J. Hazan, J. U. Gajda, J. G. Cea, G. Bottini, G. Damalik, F. Le Doze, G. Bonaldi, J. M. Hew, C. Messina, A. M. Kennedy, J. M. Carney, N. 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Brasic, W. Heide, I. Santilli, W. M. Korn, D. Selcuki, M. J. Barrett, D. Krieger, T. Leon, T. Houallah, M. Tournilhac, C. Nos, D. Chavot, F. Barbieri, F. J. Jimenez-Jimenez, J. Muruzabal, K. Poeck, A. Sennlaub, L. M. Iriarte, L. G. Lazzarino, C. Sanz, P. A. Fischer, S. D. Shorvon, R. Hoermann, F. Delecluse, M. Krams, O. Corabianu, F. H. Hochberg, Christopher J. Mathias, B. Debachy, C. M. Poser, L. Delodovici, A. Jimenez-Escrig, F. Baruzzi, F. Godenberg, D. Cucinotta, P. J. Garcia Ruiz, K. Maier-Hauff, P. R. Bar, R. Mezt, R. Jochens, S. Karakaneva, C. Roberti, E. Caballero, Joseph E. Parisi, M. Zamboni, T. Lacasa, B. Baklan, J. C. Gautier, J. A. Martinez-Matos, W. Pollmann, G. Thomas, L. Verze, E. Chleide, R. Alvarez Sala, I. Noel, E. Albuisson, O. Kastrup, S. I. Rapoport, H. J. Braune, H. Lörler, M. Le Merrer, A. Biraben, S. Soler, S. J. Taagholt, U. Meyding-Lamadé, K. Bleasdale-Barr, Isabella Moroni, Y. Campos, J. Matias-Guiu, G. Edan, M. G. Bousser, John B. Clark, J. Garcia de Yebenes, N. K. Olsen, P. Hitzenberger, S. Einius, Aj Thompson, Ch. J. Vecht, T. Crepin-Leblond, Klaus L. Leenders, A. Di Muzio, L. Georgieva, René Spiegel, K. Sabey, D. Ménégalli, J. Meulstee, U. Liszka, P. Giral, C. Sunol, J. M. Espadaler, A. D. Crockar, K. Varli, G. Giraud, P. J. Hülser, A. Benazzouz, A. Reggio, M. Salvatore, K. Genc, M. Kushnir, S. Barbieri, J. Ph. Azulay, M. Gianelli, N. Bathien, A. AlMemar, F. Hentati, I. Ragueneau, F. Chiarotti, R. C. F. Smits, A. K. Asbury, F. Lacruz, B. Muller, Alan J. Thompson, Gordon Smith, K. Schmidt, C. Daems Monpeun, Juergen Weber, A. Arboix, G. R. Fink, A. M. Cobo, M. Ait Kaci Ahmed, E. Gencheva, Israel-Biet, G. Schlaug, P. De Jonghe, Philip Scheltens, K. Toyka, P. Gonzalez-Porque, A. Cila, J. M. Fernandez, P. Augustin, J. Siclia, S. Medaglini, D. E. Ziogas, A. Feve, L. Kater, G. J. E. Rinkel, D. Leppert, Rüdiger J. Seitz, S. Ried, C. Turc-Carel, G. Smeyers, F. Godinho, M. Czygan, M. Rijntjes, E. Aversa, M. Frigo, Leif Østergaard, J. L. Munoz Blanco, A. Cruz-Matinez, J. De Reuck, C. Theillet, T. Barroso, V. Oikonen, Florence Lebert, M. Kilinc, C. Cordon-Cardon, G. Stoll, E. Thiery, F. Pulcinelli, J. Solski, M. Schmiegelow, L. J. Polman, P. Fernandez-Calle, C. Wikkelso, M. Ben Hamida, M. Laska, E. Kott, W. Sulkowski, C. Lucas, N. M. Bornstein, D. Schmitz, M. W. Lammers, A. de Louw, R. J. S. Wise, P. A. van Darn, C. Antozzi, P. Villanueva, P. H. E. Hilkens, C. Constantin, W. Ricart, A. Wolf, M. Gamba, P. Maguire, Alessandro Padovani, B. M. Patten, Marie Sarazin, H. Ackermann, L. Durelli, S. Timsit, Sebastian Jander, B. W. Scheithauer, G. Demir, J. P. Neau, P. Barbanti, A. Brand, N. AraÇ, V. Fischer-Gagnepain, R. Marchioli, G. Serratrice, C. Maugard-Louboutin, G. T. Spencer, D. Lücke, G. Mainardi, K. Harmant Van Rijckevorsel, G. B. Creel, R. Manzanares, Francesco Fortunato, A. May, J. Workman, K. Johkura, E. Fernandez, Carlo Colosimo, L. Calliauw, L. Bet, Félix F. Cruz-Sánchez, M. Dhib, H. Meinardi, F. Carrara, J. Kuehnen, C. Peiro, H. Lassmann, K. Skovgaard Olsen, A. McDonald, L. Sciulli, A. Cobo, A. Monticelli, B. Conrad, J. Bagunya, J. Benitez, V. Desnizza, B. Dupont, O. Delrieu, D. Moraes, J. J. Heimans, F. Garcia Rio, M. Matsumto, A. Fernandez, R. Nermni, R. Chalmers, M. J. Marchau, F. Aguado, P. Velupillai, P. J. Martin, P. Tassan, V. Demarin, A. Engelien, T. Gerriets, Comar, J. L. Carrasco, J. P. Pruvo, A. Lopez de Munain, D. Pavitt, J. Alarcon, Chris H. Polman, B. Guldin, N. Yeni, Hartmut Brückmann, N. Wilczak, H. Szwed, R. Causaran, G. Kyriazis, M. E. Westarp, M. Gasparini, N. Pecora, J. M. Roda, E. Lang, V. Scaioli, David R. Fish, D. Caputo, O. Gratzl, R. Mercelis, A. Perretti, G. Steimetz, I. Link, C. Rigoletto, A. Catafau, G. Lucotte, M. Buti, G. Fagiolari, A. Piqueras, C. Godinot, J. C. Meurice, Erodriguez J. Dominigo, F. Lionnet, H. Grzelec, David J. Brooks, P. M. G. Munro, F. X. Weilbach, M. Maiwald, W. Split, B. Widjaja-Cramer, V. Ozturk, J. Colas, E. Brizioli, J. Calleja, L. Publio, M. Desi, R. Soffietti, P. Cortinovis-Tourniaire, E. F. Gonano, G. Cavaletti, S. Uselli, K. Westerlind, H. Betuel, C. O. Dhiver, H. Guggenheim, M. Hamon, R. Fazio, P. Lehikoinen, A. Esser, B. Sadzot, G. Fink, Angelo Antonini, D. Bendahan, V. Di Carlo, G. Galardi, A. F. Boller, M. Aksenova, Del Fiore, V. de la Sayette, H. Chabriat, A. Nicoletti, A. Dilouya, M. L. Harpin, E. Rouillet, J. Stam, A. Wolters, M. R. Delgado, Eduardo Tolosa, G. Said, A. J. Lees, L. Rinaldi, A. Schulze-Bonhage, MA Ron, C. Lefebvre, E. W. Radü, R. Alvarez, M. L. Bots, P. Reganati, S. Palazzi, A. Poggi, N. J. Scolding, V. Sazdovitch, T. Moreau, E. Maes, M. A. Estelies, P. Petkova, Jose-Felix Marti-Masso, G De La Meilleure, N. Mullatti, M. Rodegher, N. C. Notermans, T. A. T. Warner, S. Aktan, J. P. Louboutin, L. Volpe, C. Scheidt, W. Aust, C. M. Wiles, U. Schneider, S. K. Braekken, W. R. Willems, K. Usuku, Peter M. Rothwell, C. Talamon, M. L. Sacchetti, A. Codina, M. H. Marion, A. Santoro, J. Roda, A. Bordoni, D. J. Taylor, S. Ertas, H. H. Emmen, J. Vichez, V. BesanÇon, R. E. Passingham, M. L. Malosio, A. Vérier, M. Bamberg, A. W. Hansen, E. Mostacero, G. Gaudriault, Marie Vidailhet, B. Birebent, K. Strijckmans, F. Giannini, T. Kammer, I. Araujo, J. Nowicki, E. Nikolov, A. Hutzelmann, R. Gherardi, J. Verroust, L. Austoni, A. Scheller, A. Vazquez, S. Matheron, H. Holthausen, J. M. Gerard, M. Bataillard, S. Dethy, V. H. Patterson, V. Ivanez, N. P. Hirsch, F. Ozer, M. Sutter, C. Jacomet, M. Mora, Bruno Colombo, A. Sarropoulos, T. H. Papapetropoulos, M. Schwarz, D. S. Dinner, N. Acarin, B. Iandolo, J. O. Riis, P. R. J. Barnes, F. Taroni, J. Kazenwadel, L. Torre, A. Lugaresi, I. L. Henriques, S. Pauli, S. Alfonso, Pedro Quesada, A. S. T. Planting, J. M. Castilla, Thomas Gasser, M. Van der Linden, A. Alfaro, E. Nobile-Orazio, G. Popova, W. Vaalburg, F. G. A. van der Mech, L. Williams, F. Medina, J. P. Vernant, J. Yaouanq, B. Storch-Hagenlocher, A. Potemkowski, R. Riva, M. H. Mahagne, M. Ozturk, Ve. Drory, N. Konic, C. Jungreis, A. Pou Serradell, J. L. Gauvrit, G. J. Chelune, S. Hermandez, T. Dingus, L. Hewer, Ch. Koch, M. N. Metz-Lutz, G. Parlato, M. Sinaki, Charles Pierrot-Deseilligny, H. C. Diener, J. Broeckx, J. Weill-Fulazza, M. L. Villar, M. Rizzo, O. Ganslandt, C. Duran, N. A. Fletcher, G. Di Giovacchino, Susan T. Iannaccone, C. Kolig, N. Fabre, H. A. Crockard, Rita Bella, M. Tazir, E. Papagiannuli, K. Overgaard, Emma Ciafaloni, I. Lorenzetti, F. Viader, P. A. H. Millac, I. Montiel, L. H. Visser, M. Palomar, P. L. Murgia, H. Pedersen, Rafael Blesa, S. Seddigh, W. O. Renier, I. Lemahieu, H. M. L. Jansen, L. Rosin, J. Galofre, K. Mattos, M. Pondal, G. M. Hadjigeorgiou, D. Francis, L. Cantin, D. Stegeman, M. Rango, A. B. M. F. Karim, S. Schraff, B. Castellotti, I. Iriarte, E. Laborde, T. J. Tjan, R. Mutani, D. Toni, B. Bergaasco, J. G. Young, C. Klotzsch, A. Zincone, X. Ducrocq, M. Uchuya, O. J. Kolar, A. Quattrone, T. Bauermann, Nereo Bresolin, J. Vallée, B. C. Jacobs, A. Campos, Werner Poewe, J. A. Villanueva, A. W. Kornhuber, A. Malafosse, E. Diez-Tejedor, G. Jungreia, M. J. A. Puchner, A. Komiyama, O. Saribas, V. Volpini, L. Geremia, S. Bressi, A. Nibbio, Timothy E. Bates, T. z. Tzonev, E. Ideman, G. A. Damlacik, G. Martino, G. Crepaldi, T. Martino, Kjell Någren, E. Idiman, D. Samuel, J. M. Perez Trullen, Y. van der Graaf, J. O. Thorell, M. J. M. Dupuis, E. Sieber, R. D'Alessandro, C. Cazzaniga, J. Faiss, A. Tanguy, A. Schick, I. Hoksergen, A. Cardozo, R. Shakarishvili, G. K. Wennlng, J. L. Marti-Vilalta, J. Weissenbach, I. L. Simone, Amalia C. Bruni, Darius J. Adams, C. Weiller, A. Pietrangeli, F. Croria, C. Vigo-Pelfrey, Patricia Limousin, A. Ducros, G. Conti, O. Lindvall, E. Richter, M. Zuffi, A. Nappo, T. Riise, J. Wijdenes, M. J. Fernandez, J. Rosell, P. Vermersh, S. Servidei, M. S. C. Verdugo, F. Gouttiere, W. Solbach, M. Malbezin, I. S. Watanabe, A. Tumac, W. I. McDonald, D. A. Butterfield, P. P. Costa, F. deRino, F. Bamonti, J. M. Cesar, C. H. Lahoz, I. Mosely, M. Starck, M. H. Lemaitre, K. M. Stephan, S. Tex, R. Bokonjic, I. Mollee, L. Pastena, M. Gutierrez, F. Boiler, M. C. Martinez-Para, M. Velicogna, O. Obuz, A. Grinspan, M. Guarino, L. M. Cartier, E. Ruiz, D. Gambi, S. Messina, M. Villa, Michael G. Hanna, J. Valk, Leone Pascual, M. Clanet, Z. Argov, B. Ryniewicz, E. Magni, B. Berlanga, K. S. Wong, C. Gellera, C. Prevost, F. Gonzalez-Huix, R. Petraroli, J. E. G. Benedikz, I. Kojder, C. Bommelaer, L. Perusse, M. R. Bangioanni, Guy M. McKhann, A. Molina, C. Fresquet, E. Sindern, Florence Pasquier, M. J. Rosas, M. Altieri, O. Simoncini, M. Koutroumanidis, C. A. F. Tulleken, M. Dary-Auriol, S. Oueslati, H. Kruyer, I. Nishisho, C. R. Horning, A. Vital, G. V. Czettritz, J. Ph. Neau, B. Mihout, A. Ameri, M. Francis, S. Quasthoff, D. Taussig, S. Blunt, P. Valentin, C. Y. Gao, O. Heinzlef, H. d'Allens, C. Coudero, M. Erfas, G. Borghero, P. J. Modrego Pardo, M. C. Patrosso, N. L. Gershfeld, P. A. J. M. Boon, O. Sabouraud, M. Lara, J. Svennevig, G. L. Lenzi, A. Barrio, H. Villaroya, JosÇ M. Manubens, O. Boespflug-Tanguy, M. Carreras, D. A. Costiga, J. P. Breux, S. Lynn, C. Oliveras Ley, A. G. Herbaut, J. Nos, C. Tornali, Y. A. Hekster, J. L. Chopard, J. M. Manubens, P. Chemouilli, A. Jovicic, F. Dworzak, S. Smirne, S. E. Soudain, B. Gallano, D. Lubach, G. Masullo, G. Izquierdo, A. Pascual Leone Pascual, A. Sessa, V. Freitas, O. Crambes, L. Ouss, G. W. Van Dijk, P. Marchettini, P. Confalonieri, M. Donaghy, A. Munnich, M. Corbo, and M. E. L. van der Burg
Subjects: Neurology, business.industry, Media studies, Library science, Medicine, Neurology (clinical), business
Published: 1994
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17. Motor system abnormalities in hereditary spastic paraparesis type 4 (SPG4) depend on the type of mutation in the spastin gene

Author: C. Neumann, Sven Klimpe, J. Schickel, A Schwindt, C Weiller, D Palm, J Hazan, J Liepert, Thomas Deufel, P Navratil, and D Bönsch
Subjects: Paper, Adult, Male, Spastin, Genotype, DNA Mutational Analysis, Locus (genetics), Biology, Gene product, medicine, Humans, Spasticity, Gene, Aged, Genes, Dominant, Genetics, Adenosine Triphosphatases, Aged, 80 and over, Chromosome Aberrations, Neurologic Examination, Spastic Paraplegia, Hereditary, Calcium-Binding Proteins, Middle Aged, Psychiatry and Mental health, Phenotype, Mutation, Mutation testing, Surgery, Female, Refsum Disease, Neurology (clinical), Age of onset, medicine.symptom
Abstract: Background: Hereditary spastic paraparesis (HSP) denotes a group of inherited neurological disorders with progressive lower limb spasticity as their clinical hallmark; a large proportion of autosomal dominant HSP belongs to HSP type 4, which has been linked to the SPG4 locus on chromosome 2. A variety of mutations have been identified within the SPG4 gene product, spastin. Objective: Correlation of genotype and electrophysiological phenotype. Material: Two large families with HSP linked to the SPG4 locus with a very similar disease with respect to age of onset, progression, and severity of symptoms. Methods: Mutation analysis was performed by PCR from genomic DNA and cDNA, and direct sequencing. The motor system was evaluated using transcranial magnetic stimulation. Results: Patients differ in several categories depending on the type of mutation present. Conclusions: For the first time in hereditary spastic paraparesis, a phenotypic correlate of a given genetic change in the spastin gene has been shown.
Published: 2003

18. Genetic Mapping of the Human Growth Hormone-Releasing Factor Gene (GHRF) Using Two Intragenic Polymorphisms Detected by PCR Amplification

Author: John A. Phillips, L.A. Pérez Jurado, F.V. Schaefer, J.L. Weber, Jesús Argente, Marshall L. Summar, J. Mao, and J. Hazan
Subjects: Genetic Markers, DNA, Complementary, Genetic Linkage, Molecular Sequence Data, Chromosomes, Human, Pair 20, Locus (genetics), Biology, Growth Hormone-Releasing Hormone, Polymerase Chain Reaction, Restriction map, Gene mapping, Genetic linkage, Gene duplication, Genetics, Humans, Allele, Growth Disorders, Polymorphism, Genetic, Base Sequence, Chromosome Mapping, Molecular biology, Introns, Genetic marker, Growth Hormone, Restriction fragment length polymorphism
Abstract: The authors have analyzed the human growth hormone-releasing factor (GHRF) gene by high-resolution restriction mapping of its PCR amplification products. Two intragenic PCR fragment length polymorphisms (PCRFLPs) were detected in introns A and C of the GHRF gene, whose heterozygosities are 40 and 7%, respectively. Linkage analysis using the CEPH panel showed that GHRF is linked to several markers on chromosome 20 and assigned the GHRF locus to a region near the centromere between D2OS27 (assigned to 20p12.1-p11.23) and D20S16 (assigned to 20q12). These intragenic PCRFLPs and the tightly linked polymorphisms should provide useful markers for linkage studies of GHRF alleles in familial disorders of growth such as isolated growth hormone deficiency. 12 refs., 2 figs.
Published: 1994
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19. Autosomal dominant (AD) pure spastic paraplegia (HSP) linked to locus SPG4 affects almost exclusively males in a large pedigree

Author: J Hazan, Mayana Zatz, Sueli K.N. Marie, P Rocco, Maria Rita Passos-Bueno, and Alessandra Starling
Subjects: Male, Ataxia, Spastin, Hereditary spastic paraplegia, Genetic Linkage, DNA Mutational Analysis, Locus (genetics), Biology, Electronic Letter, Genetic linkage, Genetics, medicine, Humans, Genetics (clinical), X-linked recessive inheritance, Genes, Dominant, Adenosine Triphosphatases, Sex Characteristics, Genetic heterogeneity, Ichthyosis, Spastic Paraplegia, Hereditary, Haplotype, Chromosome Mapping, medicine.disease, Pedigree, Haplotypes, Female, medicine.symptom, Lod Score
Abstract: Hereditary spastic paraplegia (HSP) includes a heterogeneous group of degenerative disorders of the central motor system characterised by progressive spasticity of the lower limbs. The inheritance may be autosomal dominant (AD), autosomal recessive (AR), or X linked. Clinically, two forms of HSP can be distinguished: a pure form, with leg spasticity and weakness, and a complicated form, with other manifestations such as optic neuropathy, retinopathy, movement disorders, dementia, epilepsy, ataxia, ichthyosis, mental retardation, and deafness. Both complicated and pure forms are genetically heterogeneous. Although X linked forms have been reported,1,2 pure HSP usually displays AD inheritance. The major neuropathological finding in the latter form is axonal degeneration involving the terminal ends of the longest fibres of the corticospinal tracts and dorsal columns.3,4 AD-HSP is the most common form of the disease, accounting for approximately 70-80% of the families. Seven AD loci have been mapped to date: SPG3 on chromosome 14q11.2-q24.3,5,6 SPG4 on chromosome 2p,7,8 SPG6 on chromosome 15q11.1,9 SPG8 on chromosome 8q23-q24,10–13 SPG10 on chromosome 12q13,14 and more recently two novel loci were mapped on chromosome 2q24-q3415 and chromosome 19q13.16 SPG4 is the most common form, accounting for about 40% of all AD-HSP families.17,18 The protein encoded by SPG4, spastin,19 and more recently by SPG3, a GTPAse (SPG3A),20 has just been identified but the gene product of the other AD-HSP forms is still unknown. Here we report a large three generation family referred to us with a diagnosis of pure spastic paraplegia. Pedigree analysis showed the existence of 24 clinically affected males but only one clinically affected female. However, X linked inheritance was ruled out since there were several instances of male to male transmission. Linkage analysis showed that the disease gene …
Published: 2002

20. Repair of bone allograft fracture using bone morphogenetic protein-2

Author: Mark C. Gebhardt, Eric J. Hazan, Stephen K Storer, Henry J. Mankin, and Francis Young-In Lee
Subjects: medicine.medical_specialty, Pathology, medicine.medical_treatment, Radiography, Nonunion, Human bone, Bone Morphogenetic Protein 2, Bone healing, Osteotomy, Bone morphogenetic protein 2, Fibrosis, Transforming Growth Factor beta, medicine, Animals, Orthopedics and Sports Medicine, Bony Callus, Fracture Healing, Bone allograft, business.industry, General Medicine, medicine.disease, Recombinant Proteins, Surgery, Rats, surgical procedures, operative, Rats, Inbred Lew, Bone Morphogenetic Proteins, Models, Animal, business, Femoral Fractures
Abstract: Long-term clinical data have shown that reconstruction using bone allografts provide adequate function after extensive tumor surgery. Complications such as nonunion of allograft-host interface, infection, and allograft fracture often require major revision surgeries. Allograft fractures usually do not induce the same repair process that is seen in normal fracture healing. The authors did an experimental study to test whether bone morphogenetic protein-2 can induce and achieve osseous repair in an allograft osteotomy model. Recombinant human bone morphogenetic protein-2 was applied at femoral intercalary allograft osteotomy sites in 20 rats. Forty additional rats served as controls (carrier alone and sham). Specimens in all groups were examined histologically and radiographically at 4 and 8 weeks. Specimens in the control groups showed only fibrosis by 8 weeks. In contrast, none of 10 specimens in the experimental group showed radiographic union at 8 weeks. New bone formation and integration with underlying allografts were seen in the experimental group as early as 4 weeks. These data suggest that fracture repair in the allograft bone can be triggered by a biologic regulator that is expressed during normal fracture healing.
Published: 2002

21. The effect of adjuvant chemotherapy on osteoarticular allografts

Author: Mark C. Gebhardt, Francis J. Hornicek, Willam Tomford, Eric J. Hazan, and Henry J. Mankin
Subjects: musculoskeletal diseases, Adult, Male, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Nonunion, Chondrosarcoma, Bone Neoplasms, medicine, Humans, Transplantation, Homologous, Orthopedics and Sports Medicine, Femur, Child, Neoadjuvant therapy, Aged, Chemotherapy, Osteosarcoma, Bone Transplantation, Tibia, business.industry, General Medicine, Middle Aged, Plastic Surgery Procedures, medicine.disease, Surgery, Transplantation, Amputation, Chemotherapy, Adjuvant, Orthopedic surgery, Female, business
Abstract: Two hundred lower extremity osteoarticular allografts (in 200 patients) performed for aggressive or malignant bone tumors between 1976 and 1997 included 124 grafts of the distal femur, 46 of the proximal tibia, and 30 of the proximal femur. Seventy-four patients did not receive chemotherapy, and 126 received either adjuvant or neoadjuvant therapy. The diagnoses, mean ages, and length of followup were different for the two groups because most of the patients in the chemotherapy group had osteosarcoma, whereas the largest number in the control group had chondrosarcoma or parosteal osteosarcoma. The extent of the surgery was essentially the same for both patient groups, as is reflected by a low recurrence rate (7% for the control and 6% for the chemotherapy group). A statistical comparison of the various parameters showed that the infection, fracture, and amputation rates were the same, but the nonunion rate was markedly increased in the patients who received chemotherapy (32% versus 12%). Cox regression and Kaplan-Meier studies showed that chemotherapy had a significant effect on outcome, with the success rates for the two groups being quite different (72% versus 56%). The results for the distal femur showed a greater effect than for either the proximal tibia or the proximal femur. Analysis of these data suggest the distal femur is perhaps the most prone to healing problems, possibly based in part on the extent of the surgery. A final study supports the concept that the results improved in later years, suggesting a modification or application of the drugs used, better selection of patients, and improvements in surgical technique.
Published: 2001

22. Variability of measurement of glenoid version on computed tomography scan

Author: Desmond J. Bokor, Michael D O'Sullivan, and Georges J Hazan
Subjects: Orthodontics, medicine.diagnostic_test, Rotation, business.industry, Computed tomography, General Medicine, Anatomy, Curvature, Scapula, Orientation (geometry), Coronal plane, medicine, Perpendicular, Humans, Orthopedics and Sports Medicine, Surgery, Tomography, business, Tomography, X-Ray Computed
Abstract: The purpose of the study was to determine the variability of measurement that might occur with rotation of the scapula in the coronal plane when computed tomography scanning is used. Ten dry scapula specimens had 4 sets of computed tomography scans performed at +20 degrees, +10 degrees, neutral, and -10 degrees of scapula rotation. The angle of glenoid version was then measured according to the technique of Friedman. The measured value for glenoid version was noted to vary by as much as 10 degrees on the same specimen with minor rotation of the scapula. This result occurred because of differences in the curvature of the vertebral border of the scapula. The measured angle of glenoid version was most likely to vary with rotation of the scapula 10 degrees downward (i.e., glenoid articular surface facing 10 degrees upward). For accurate and reproducible measurement of the glenoid version, it is essential that in the scout view the glenoid orientation is neutral (i.e., glenoid surface is perpendicular to the plane of the computed tomography cut).
Published: 2000

23. [Clinical and molecular genetic analysis of 4 Swiss families with the pure form of hereditary spastic spinal paralysis]

Author: J, von Fellenberg, C, Paternotte, J F, Prud'homme, J, Weissenbach, J, Hazan, and J M, Burgunder
Subjects: Adult, Aged, 80 and over, Chromosome Aberrations, Male, Spastic Paraplegia, Hereditary, Chromosome Disorders, Middle Aged, Spinal Cord Diseases, Pedigree, Haplotypes, Humans, Paralysis, Female, Molecular Biology, Switzerland, Aged
Abstract: Hereditary spastic paraplegia (HSP) is a rare neurodegenerative disease of the spinal cord with a progressive gait disorder, associated with other neurological abnormalities in the complicated form. A cluster of families with this disorder in the central part of the country has long been known to Swiss neurologists. In the present report, we describe our clinical and molecular findings in four large families originating from this region and suffering from a pure HSP form. Clinical presentation was similar in the four families. The age of onset varied widely from 2 to 70 years with the appearance of a gait disorder, which slowly progressed to wheelchair confinement after 30-70 years. No other neurological abnormality was found except for impairment of the vibration sense and sphincter abnormalities. In three families an association with markers of the SPG4 locus on chromosome 2 was found. In the fourth, the largest one, no linkage could be found with either SPG4, or with the other two known loci, SPG3 on chromosome 14 and SPG6 on chromosome 15. These data demonstrate the genetic heterogeneity in HSP, even in families from the same region. They also suggest the presence of at least one additional locus for the pure form.
Published: 1998

24. Foreword

Author: Eric J. Hazan
Subjects: Orthopedics and Sports Medicine
Published: 2003
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25. A dinucleotide repeat polymorphism at the Kallmann locus (Xp22.3)

Author: Jeremy Kirk, Jacqueline Levilliers, J.-P. Hardelin, Renaud Legouis, J. Hazan, Jean Weissenbach, Patricia B. Munroe, Pierre-Marc Bouloux, and Christine Petit
Subjects: Genetics, Polymorphism, Genetic, X Chromosome, Base Sequence, Kallmann syndrome, Molecular Sequence Data, Locus (genetics), Biology, medicine.disease, Polymerase Chain Reaction, Molecular biology, Oligodeoxyribonucleotides, Gene mapping, Genetic marker, medicine, Humans, Allele, Restriction fragment length polymorphism, Allele frequency, Alleles, X chromosome, Repetitive Sequences, Nucleic Acid
Published: 1991
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26. Apport des Mesures de Resistance de Polarisation et D'Impedance Electrochimique a L'Evaluation de la Resistance a la Corrosion des Aciers Galvanises Chromates

Author: E. Buscarlet, J. Hazan, and Christian Coddet
Subjects: Materials science, Mechanics of Materials, Mechanical Engineering, Metallurgy, General Materials Science, Condensed Matter Physics
Published: 1986
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27. Einleitung – Introduction – Introducción

Author: F. Thedering, E. Lüthy, S. Aarseth, H. Thölen, M lle, J. Dighiero, J. Zbinden, J. Hazan, J. Odier, K. Endte, H. Thaler, R.W. Oblath, Ch. Finas, J.M. Barber, I. Leusen, F. Troçolo, G.C. Griffith, M. Piller, P. von Planta, J. Lenègre, E.F. Hueber, H.I. Russek, K.F. Gey, F.M. Murphy, J.-L. Rivier, R. Méndez, J. Rudolf, A. Gerbaux, Dalla Volta, J. Cahn, U. Isler, R.W. Emanuel, M. Krause, C.V. Aguirre, sup>M. Herold, A. Pineyro, R. Froment, L. Suter, B. Pellmont, S. Moeschlin, J. Aceves, G. Forster, P. Cahen, Casellas Bernat, L.E. Todd, A. Pletscher, E. Läuppi, M. Holzmann, R. Hegglin, St. Greif, P.W. Duchosal, F. Schaub, L. Abecasis, R. Moreira, and P. Pulido
Subjects: business.industry, Medicine, Pharmacology (medical), Cardiology and Cardiovascular Medicine, business, Humanities
Published: 1960
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28. Contents, Vol. 37(Suppl. 2), 1960

Author: H.I. Russek, M. Holzmann, J. Dighiero, R. Hegglin, R. Froment, J.-L. Rivier, Ch. Finas, J. Zbinden, J. Odier, M. Krause, G. Forster, J.M. Barber, P.W. Duchosal, U. Isler, C.V. Aguirre, I. Leusen, F. Thedering, R. Méndez, R.W. Oblath, F. Troçolo, G.C. Griffith, M lle, H. Thölen, K. Endte, F.M. Murphy, A. Pineyro, S. Aarseth, H. Thaler, Casellas Bernat, R.W. Emanuel, M. Piller, B. Pellmont, S. Moeschlin, J. Hazan, J. Aceves, St. Greif, E. Lüthy, L.E. Todd, P. Cahen, J. Lenègre, F. Schaub, K.F. Gey, E.F. Hueber, L. Abecasis, R. Moreira, L. Suter, P. von Planta, A. Pletscher, P. Pulido, E. Läuppi, J. Rudolf, A. Gerbaux, Dalla Volta, J. Cahn, and sup>M. Herold
Subjects: Traditional medicine, business.industry, Medicine, Pharmacology (medical), Cardiology and Cardiovascular Medicine, business
Published: 1960
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29. Schlußfolgerungen und Gesamt-Zusammenfassung

Author: E.F. Hueber, S. Aarseth, J. Dighiero, F. Schaub, J. Odier, J. Zbinden, I. Leusen, F. Troçolo, B. Pellmont, S. Moeschlin, J. Aceves, G.C. Griffith, J.M. Barber, F.M. Murphy, R.W. Oblath, P. Pulido, P.W. Duchosal, Ch. Finas, J. Hazan, H. Thaler, R.W. Emanuel, J.-L. Rivier, R. Froment, G. Forster, U. Isler, M. Piller, E. Lüthy, L.E. Todd, A. Pineyro, sup>M. Herold, L. Suter, R. Méndez, H. Thölen, K.F. Gey, F. Thedering, J. Cahn, St. Greif, M. Holzmann, R. Hegglin, P. von Planta, L. Abecasis, R. Moreira, M. Krause, J. Rudolf, A. Gerbaux, C.V. Aguirre, M lle, Dalla Volta, K. Endte, J. Lenègre, H.I. Russek, Casellas Bernat, P. Cahen, A. Pletscher, and E. Läuppi
Subjects: Gynecology, medicine.medical_specialty, business.industry, Medicine, Pharmacology (medical), Cardiology and Cardiovascular Medicine, business
Published: 1960
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30. Conclusiones y resumen general

Author: P. Pulido, R. Froment, J. Lenègre, A. Pletscher, J. Cahn, A. Pineyro, E. Läuppi, L.E. Todd, H.I. Russek, G. Forster, Ch. Finas, L. Suter, F.M. Murphy, F. Schaub, H. Thölen, P.W. Duchosal, F. Thedering, R.W. Emanuel, I. Leusen, P. Cahen, H. Thaler, F. Troçolo, G.C. Griffith, J. Odier, J. Dighiero, Casellas Bernat, M. Krause, R.W. Oblath, J.-L. Rivier, B. Pellmont, S. Moeschlin, E.F. Hueber, C.V. Aguirre, J. Zbinden, R. Méndez, St. Greif, U. Isler, J. Aceves, sup>M. Herold, E. Lüthy, M lle, S. Aarseth, K. Endte, L. Abecasis, R. Moreira, K.F. Gey, J. Hazan, P. von Planta, J. Rudolf, A. Gerbaux, Dalla Volta, M. Holzmann, R. Hegglin, M. Piller, and J.M. Barber
Subjects: business.industry, Medicine, Pharmacology (medical), Cardiology and Cardiovascular Medicine, business, Humanities
Published: 1960
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31. Conclusions and General Summary

Author: C.V. Aguirre, S. Aarseth, J.-L. Rivier, J. Cahn, P. Cahen, J. Hazan, M lle, A. Pineyro, K. Endte, J.M. Barber, L. Abecasis, R. Moreira, R. Froment, U. Isler, L. Suter, J. Dighiero, A. Pletscher, Ch. Finas, P. von Planta, R. Méndez, H. Thaler, H. Thölen, E. Läuppi, B. Pellmont, S. Moeschlin, E.F. Hueber, J. Aceves, K.F. Gey, J. Odier, F.M. Murphy, sup>M. Herold, G. Forster, I. Leusen, F. Troçolo, G.C. Griffith, R.W. Emanuel, L.E. Todd, R.W. Oblath, F. Schaub, St. Greif, H.I. Russek, M. Piller, J. Rudolf, M. Holzmann, P. Pulido, A. Gerbaux, R. Hegglin, Casellas Bernat, E. Lüthy, Dalla Volta, J. Zbinden, F. Thedering, P.W. Duchosal, J. Lenègre, and M. Krause
Subjects: medicine.medical_specialty, business.industry, Family medicine, Medicine, Pharmacology (medical), Cardiology and Cardiovascular Medicine, business, General Summary
Published: 1960
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32. [Surgical treatment of mitral stenosis; personal experiences]

Author: A, SANJINES, J, DIGHIERO, J, HAZAN, E J, CANABAL, J O, HORJALES, and C V, AGUIRRE
Subjects: Humans, Mitral Valve Stenosis
Published: 1957

33. The lipotropic action of threonine and related substances in the rat

Author: S A, SINGAL, S J, HAZAN, V P, SYDENSTRICKER, and J M, LITTLEJOHN
Subjects: Threonine, Lipotropic Agents, Liver, Serine, Animals, Amino Acids, Rats
Published: 1953

34. The production of fatty livers in rats on threonine-and lysine-deficient diets

Author: S A, SINGAL, S J, HAZAN, V P, SYDENSTRICKER, and J M, LITTLEJOHN
Subjects: Fatty Liver, Threonine, Liver Diseases, Lysine, Animals, Amino Acids, Diet, Rats
Published: 1953

35. [Original contributions to angiocardiographic diagnosis and technic]

Author: C V, AGUIRRE, J, PURCALLAS, P, SCREMINI ALGORTA, J, DIGHIERO, E J, CANABAL, C V, SUZACQ, J O, HORJALES, J, HAZAN, and J M, BALDOMIR
Subjects: Echinococcosis, Angiography, Humans, Mitral Valve Stenosis, Heart, Cardiovascular System
Published: 1955

36. The effect of threonine deficiency on the synthesis of some phosphorus fractions in the rat

Author: S A, SINGAL, S J, HAZAN, V P, SYDENSTRICKER, and J M, LITTLEJOHN
Subjects: Threonine, Liver, Animals, Phosphorus, Amino Acids, Lipid Metabolism, Antifibrinolytic Agents, Phospholipids, Rats
Published: 1953

37. [ELECTRICAL VENTRICULAR PREPONDERANCES]

Author: C V, AGUIRRE, J O, HORJALES, J, HAZAN, J, DIGHIERO, and S, ROSSI
Subjects: Electricity, Heart Ventricles, Vectorcardiography, Humans
Published: 1964

38. [Complete paroxysmal arrythmia caused by oculocardiac reflex]

Author: C V, AGUIRRE, E J, CANABAL, J, DIGHIERO, J, HAZAN, J O, HORJALES, and P, SCREMINI ALGORTA
Subjects: Reflex, Oculocardiac, Tachycardia, Reflex, Humans, Arrhythmias, Cardiac, Tachycardia, Paroxysmal
Published: 1956

39. [Personal experience on the question of cardiac echinococcosis]

Author: E J, CANABAL, J, DIGHIERO, C V, AGUIRRE, J M, BALDOMIR, J, PURCALLAS, C V, SUZACQ, J O, HORJALES, J, HAZAN, and P, SCREMINI ALGORTA
Subjects: Heart Diseases, Echinococcosis, Diagnostic Techniques, Cardiovascular, Humans, Heart
Published: 1957

40. [Remarks on vascular sutures for the use of general surgeon]

Author: J P, Binet and J, Hazan
Subjects: Suture Techniques, Humans, Surgical Instruments, Vascular Surgical Procedures
Published: 1965

41. [Action of a new monoamine oxidase inhibitor (RO 4-2637) on anginous pain]

Author: J, HAZAN, J, DIGHIERO, S, FIELDMAN, and J, RUDOLF
Subjects: Monoamine Oxidase Inhibitors, Pain, Angina Pectoris
Published: 1962

42. [Acute hydatid pulmonary heart disease]

Author: C V, AGUIRRE, J M, BALDOMIR, E J, CANABAL, J, DIGHIERO, J, HAZAN, J O, HORJALES, J, PURCALLAS, and C V, SUZACQ
Subjects: Pulmonary Heart Disease, Echinococcosis, Acute Disease, Humans, Vascular Diseases
Published: 1956

43. THE MENOPAUSE--FLUSH, FANTASY, AND DENIAL

Author: S J, HAZAN and R, CONNEELY
Subjects: Placebos, Estradiol Congeners, Contraceptive Agents, Female, Humans, Chlordiazepoxide, Estrogens, Female, Menopause, Toxicology, Fantasy
Published: 1964

44. [Clinical study of a derivative of iproniazid, tersavid, in the treatment of angina pectoris]

Author: J, DIGHIERO, J, HAZAN, and J, RUDOLF
Subjects: Biomedical Research, Propionates, Iproniazid, Angina Pectoris
Published: 1960

45. [Kinetocardiogram]

Author: J, Dighiero, J O, Horjales, C V, Aguirre, S, Rossi, J, Hazan, and A, Fabius
Subjects: Heart Diseases, Heart Function Tests, Humans, Kinetocardiography
Published: 1964

46. [Aerobacter cloacae septicemia cured by antibiotic and corticotherapy]

Author: R, BASTIN, F, VERLIAC, C, LAPRESLE, V, DAVID, and J, HAZAN
Subjects: Chloramphenicol, Hydrocortisone, Colistin, Kanamycin, Sepsis, Enterobacter, Humans, Penicillins, Dexamethasone, Anti-Bacterial Agents
Published: 1963

47. Spectrum of SPG4 mutations in autosomal dominant spastic paraplegia

Author: N, Fonknechten, D, Mavel, P, Byrne, C S, Davoine, C, Cruaud, D, Bönsch, D, Boentsch, D, Samson, P, Coutinho, M, Hutchinson, P, McMonagle, J M, Burgunder, A, Tartaglione, O, Heinzlef, I, Feki, T, Deufel, N, Parfrey, A, Brice, B, Fontaine, J F, Prud'homme, J, Weissenbach, A, Dürr, and J, Hazan
Subjects: Adult, Spastin, Adolescent, Genotype, Hereditary spastic paraplegia, RNA Splicing, Molecular Sequence Data, Mutation, Missense, Locus (genetics), Biology, medicine, Genetics, Missense mutation, Humans, Child, Gene, Molecular Biology, Genetics (clinical), Microtubule severing, Aged, Genes, Dominant, Adenosine Triphosphatases, Paraplegia, Polymorphism, Genetic, Genetic heterogeneity, General Medicine, Middle Aged, medicine.disease, Phenotype, Codon, Nonsense, Mutation, Asymptomatic carrier
Abstract: Autosomal dominant hereditary spastic paraplegia (AD-HSP) is a group of genetically heterogeneous neurodegenerative disorders characterized by pro- gressive spasticity of the lower limbs. Five AD-HSP loci have been mapped to chromosomes 14q, 2p, 15q, 8q and 12q. The SPG4 locus at 2p21-p22 has been shown to account for approximately 40% of all AD-HSP families. SPG4 encoding spastin, a putative nuclear AAA protein, has recently been identified. Here, sequence analysis of the 17 exons of SPG4 in 87 unrelated AD-HSP patients has resulted in the detection of 34 novel mutations. These SPG4 mutations are scattered along the coding region of the gene and include all types of DNA modification including missense (28%), nonsense (15%) and splice site point (26.5%) mutations as well as deletions (23%) and insertions (7.5%). The clinical analysis of the 238 mutation carriers revealed a high proportion of both asymptomatic carriers (14/238) and patients unaware of symptoms (45/238), and permitted the redefinition of this frequent form of AD-HSP.

48. Real-time oscilloscope observation of an ultrafast photodiode response to mode-locked laser pulses

Author: J. Haisma, J. Nussli, J. Hazan, and G. Marie
Subjects: Physics, business.industry, Direct current, Photodetector, Condensed Matter Physics, Laser, Atomic and Molecular Physics, and Optics, Photodiode, law.invention, Pulse (physics), Full width at half maximum, Optics, law, Optoelectronics, Electrical and Electronic Engineering, Oscilloscope, business, Ultrashort pulse
Abstract: Pulses of 100 ps full width at half maximum (FWHM) have been displayed on a direct current to 5-GHz real-time oscilloscope. The 100-ps duration includes contributions from the oscilloscope, the photodetector, and the laser pulse,Maximum current in the linear regime of the photodiode is ≈3 amperes so that electric pulses of ≈70 ps FWHM and ≈150 volts can be obtained with the laser-detector combination. Results of a simple optical method for determining the exposure time of high-speed electronic cameras are also briefly given.
Published: 1970
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49. Measurement and Statistical Theory Analysis ofFe56(He3, p)andCu63(He3, p)Energy and Angular Distributions—Nuclear Shell Effects

Author: J. Hazan and G. Merkel
Subjects: Nuclear physics, Nuclear reaction, Physics, Angular distribution, Helium-3, Shell (structure), General Physics and Astronomy, Neutron, Nuclear cross section, Atomic physics, Statistical theory, Excitation, Energy (signal processing)
Published: 1966
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50. Tubulin glutamylation regulates axon guidance via the selective tuning of microtubule-severing enzymes.

Author: Ten Martin D, Jardin N, Vougny J, Giudicelli F, Gasmi L, Berbée N, Henriot V, Lebrun L, Haumaître C, Kneussel M, Nicol X, Janke C, Magiera MM, Hazan J, and Fassier C
Subjects: Animals, Mice, Axons metabolism, Peptide Synthases metabolism, Peptide Synthases genetics, Motor Neurons metabolism, Zebrafish Proteins metabolism, Zebrafish Proteins genetics, Protein Processing, Post-Translational, Axon Guidance, Zebrafish metabolism, Spastin metabolism, Spastin genetics, Katanin metabolism, Katanin genetics, Microtubules metabolism, Tubulin metabolism
Abstract: The microtubule cytoskeleton is a major driving force of neuronal circuit development. Fine-tuned remodelling of this network by selective activation of microtubule-regulating proteins, including microtubule-severing enzymes, has emerged as a central process in neuronal wiring. Tubulin posttranslational modifications control both microtubule properties and the activities of their interacting proteins. However, whether and how tubulin posttranslational modifications may contribute to neuronal connectivity has not yet been addressed. Here we show that the microtubule-severing proteins p60-katanin and spastin play specific roles in axon guidance during zebrafish embryogenesis and identify a key role for tubulin polyglutamylation in their functional specificity. Furthermore, our work reveals that polyglutamylases with undistinguishable activities in vitro, TTLL6 and TTLL11, play exclusive roles in motor circuit wiring by selectively tuning p60-katanin- and spastin-driven motor axon guidance. We confirm the selectivity of TTLL11 towards spastin regulation in mouse cortical neurons and establish its relevance in preventing axonal degeneration triggered by spastin haploinsufficiency. Our work thus provides mechanistic insight into the control of microtubule-driven neuronal development and homeostasis and opens new avenues for developing therapeutic strategies in spastin-associated hereditary spastic paraplegia., Competing Interests: Disclosure and competing interests statement. The authors declare no competing interests., (© 2024. The Author(s).)
Published: 2025
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