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This paper introduces the research on guide band welding in China and other countries, analyzes the characteristics of guide bands produced by remelt deposit welding and the application of the welding process to the joining between thin-walled submunition-based projectiles with a large caliber and launched by a howitzer. In addition, this paper raises the performance testing requirements for the grooveless remelt deposit welding process.

The structure of nuclei around the neutron-rich nucleus 132Sn is of particular interest due to the vicinity of the Z = 50 and N = 82 shell closures and the r-process nucleosynthetic path. Four states in 131Sn with a strong single-particle-like component have previously been studied via the (d,p) reaction, with limited excitation energy resolution. The 130Sn(9Be,8Be)131Sn and 130Sn(13C,12C)131Sn single-neutron transfer reactions were performed in inverse kinematics at the Holifield Radioactive Ion Beam Facility using particle-gamma coincidence spectroscopy. The uncertainties in the energies of the single-particle-like states have been reduced by more than an order of magnitude using the energies of gamma rays. The previous tentative Jpi values have been confirmed. Decays from high-spin states in 131Sn have been observed following transfer on the isomeric component of the 130Sn beam. The improved energies and confirmed spin-parities of the p-wave states important to the r-process lead to direct-semidirect cross-sections for neutron capture on the ground state of 130Sn at 30 keV that are in agreement with previous analyses. A similar assessment of the impact of neutron-transfer on the isomer would require significant nuclear structure and reaction theory input. There are few measurements of transfer reaction on isomers, and this is the first on an isomer in the 132Sn region., Comment: 7 pages, 4 figures

本文报道1例慢性颈深部脓肿病例，病原学提示新星诺卡菌复合群感染，该患者合并系统性红斑狼疮1年，长期口服糖皮质激素治疗。脓肿引流术后选用敏感性相对较低但副作用小的阿莫西林克拉维酸钾维持治疗，随访12个月无复发。对于免疫抑制状态下的不典型脓肿，应警惕诺卡菌感染。其抗菌治疗疗程长，首选磺胺类药物治疗，如有禁忌，备选敏感抗生素配合充分外科引流同样有效。该病罕见且临床表现及治疗特殊，加强临床、检验及药学等专科的认识及协作至关重要。.

In this work, the effect of pulse current and pulse duration in die-sinking electrical discharge machining (EDM) on the machining characteristics of Ti-6Al-4V alloy is studied. The EDM characteristics, including the electrode wear ratio (EWR), the material removal rate (MRR), and the surface roughness (SR), are used to measure the effect of machining. An increase in the intensity of the pulse current from 2.5 to 5 A produces a slow increase in EWR, MRR, and SR. An increase in the intensity of the pulse current from 5 to 7 A produces a rapid increase in EWR, MRR, and SR. Control charts are basic and powerful tools for controlling statistical processes and are widely used to monitor manufacturing processes and ensure good EDM quality. EWR, MRR, and SR are normal distributions, and the regression curves for the data are straight lines. All of the data points vary randomly around the centerline, which follows the Shewhart criteria and shows that the EDM process and product performance are under control and stable over time. After EDM, the surface exhibits an irregular fused structure, with pinholes, micro voids, globule debris, and many damaged surfaces. Oxygen plasma etching and surface modification after EDM reduce these surface defects, so finer and flatter surfaces can be achieved. Moreover, fatigue life can be enhanced.

Radioactive ^{129}Sb, which can be treated as a proton plus semimagic ^{128}Sn core within the particle-core coupling scheme, was studied by Coulomb excitation. Reduced electric quadrupole transition probabilities, B(E2), for the 2^{+}⊗πg_{7/2} multiplet members and candidate πd_{5/2} state were measured. The results indicate that the total electric quadrupole strength of ^{129}Sb is a factor of 1.39(11) larger than the ^{128}Sn core, which is in stark contrast to the expectations of the empirically successful particle-core coupling scheme. Shell-model calculations performed with two different sets of nucleon-nucleon interactions suggest that this enhanced collectivity is due to constructive quadrupole coherence in the wave functions stemming from the proton-neutron residual interactions, where adding one nucleon to a core near a double-shell closure can have a pronounced effect. The enhanced electric quadrupole strength is an early signal of the emerging nuclear collectivity that becomes dominant away from the shell closure.

International audience; Cosmic Ray Energetics And Mass for the International Space Station (ISS-CREAM) experi-ment is designed to study the composition and energy spectra of cosmic-ray particles from 10^12 to 10^15 eV. ISS-CREAM was launched and deployed to the ISS in August 2017. The ISS-CREAM payload employs a Silicon Charge Detector for charge measurements, Top and Bot-tom Counting Detector for electron-hadron separation and a low-energy trigger, a Boronated Scintillator Detector for additional electron-hadron separation, and a Calorimeter (CAL) for en-ergy measurements and a high-energy trigger. The CAL is constructed of 20 layers of tungsten plates interleaved with scintillating fiber ribbons read out by hybrid-photodiodes (HPDs) and densified carbon targets. Each CAL layer is made of 3.5 mm (1 X_0) thick tungsten plates alter-nating with fifty 0.5 mm thick and 1 cm wide scintillating fiber ribbons. Consecutive layers of fiber ribbons are installed orthogonal to each other. Energy deposition in the CAL determines the particle energy and provides tracking information to determine which segment(s) of the charge detectors to use for the charge measurement. Tracking for showers is accomplished by extrapolating each shower axis back to the charge detectors. The performance of the ISS-CREAM CAL during flight is presented.

International audience; Cosmic Ray Energetics And Mass for the International Space Station (ISS-CREAM) is an experiment for studying the origin, acceleration, and propagation mechanisms of high-energy cosmic rays. The ISS-CREAM instrument was launched on the 14th of August 2017 to the ISS aboard the SpaceX-12 Dragon spacecraft. The Top and Bottom Counting Detectors (TCD/BCD) are parts of the ISS-CREAM instrument and designed for studying electron and gamma-ray physics. The TCD/BCD each consist of an array of 20 × 20 photodiodes on a plastic scintillator. The TCD/BCD can separate electrons from protons by using the difference between the shapes of electromagnetic and hadronic showers in the high energy region. The Boosted Decision Tree (BDT) method, which is a deep learning method, is used in this separation study. We will present results of the electron/proton separation study and rejection power in various energy ranges.

International audience; The Cosmic Ray Energetics And Mass experiment for the International Space Station (ISS-CREAM) is designed and built to measure the elemental energy spectra of cosmic-ray particles (1 ≤ Z ≤ 26) and electrons. It measures the energy of incident cosmic rays from 10^12 to 10^15 eV. ISS-CREAM was launched and deployed to the ISS in August 2017. The Science Operations Center (SOC) at the University of Maryland has been operating the payload on the Interna-tional Space Station (ISS) in coordination with the Payload Operations Integration Center (POIC) at NASA’s Marshall Space Flight Center. The SOC has been responsible for sending commands to and receiving data from the Science Flight Computer (SFC) on board ISS-CREAM. The ISS-CREAM data taking program interfaces with the POIC using the Telescience Resources Kit through the Software Toolkit for Ethernet Lab-Like Architecture developed by the Boeing Company. The command uplink and data downlink have been through the Track-ing and Data Relay Satellite System. We present the ISS-CREAM flight operations including ISS communications, SFC performance, etc.

International audience; Cosmic Ray Energetics and Mass for the International Space Station (ISS-CREAM) is designed to directly measure the energy spectra of high-energy cosmic rays, encompassing proton to iron nuclei, over the energy range from 1012 to 1015 eV [1]. The capability to measure an extended energy range enables us to probe the origin and acceleration mechanisms of cosmic rays. The ISS-CREAM instrument is configured with the balloon-borne CREAM calorimeter (CAL) for energy measurements and four layers of a finely segmented Silicon Charge Detector (SCD) for charge measurements. In addition, two new compact detectors have been developed for electron/proton separation: Top and Bottom scintillator-based counting detectors (TCD/BCD) and a boronated scintillator detector (BSD). Simulations use the GEANT3 package [2] with the FLUKA hadronic model [3]. An isotropic event generator was developed for the ISS-CREAM geometry with particles incident from the upper hemisphere. We will present simulation results regarding ISS-CREAM performance, including trigger rates, energy resolution, energy response, tracking resolution, charge efficiency, etc.

Half of the elements heavier than iron are believed to be produced through the rapid neutron-capture process ($r$ process). The astrophysical environment(s) where the $r$ process occurs remains an open question, even after recent observations of neutron-star mergers and the associated kilonova. Features in the abundance pattern of $r$-process ashes may provide critical insight for distinguishing contributions from different possible sites, including neutron-star mergers and core-collapse supernovae. In particular, the largely unknown neutron-capture reaction rates on neutron-rich unstable nuclei near $^{132}\mathrm{Sn}$ could have a significant impact on the final $r$-process abundances. To better determine these neutron-capture rates, the $(d,p)$ reaction has been measured in inverse kinematics using radioactive ion beams of $^{126}\mathrm{Sn}$ and $^{128}\mathrm{Sn}$ and a stable beam of $^{124}\mathrm{Sn}$ interacting with a ${({\mathrm{CD}}_{2})}_{n}$ target. An array of position-sensitive silicon strip detectors, including the Super Oak Ridge Rutgers University Barrel Array, was used to detect light reaction products. In addition to the present measurements, previous measurements of $^{130,132}\mathrm{Sn}(d,p)$ were reanalyzed using state-of-the-art reaction theory to extract a consistent set of spectroscopic factors for $(d,p)$ reactions on even tin nuclei between the heaviest stable isotope $^{124}\mathrm{Sn}$ and doubly magic $^{132}\mathrm{Sn}$. The spectroscopic information was used to calculate direct-semidirect $(n,\ensuremath{\gamma})$ cross sections, which will serve as important input for $r$-process abundance calculations.

The exotic Borromean nucleus $^{20}$Mg with $N$ = 8, located at the proton drip-line provides a unique testing ground for nuclear forces and the evolution of shell structure in the neutron-deficient region. We report on the first observation of proton unbound resonances together with bound states in $^{20}$Mg from the $^{20}$Mg($d$,$d'$) reaction performed at TRIUMF. Phenomenological shell-model calculations offer a reasonable description. However, our experimental results present a challenge for current first-principles nuclear structure approaches and point to the need for improved chiral forces and {\it ab initio} calculations. Furthermore, the differential cross section of the first excited state is compared with distorted-wave Born approximation calculations to deduce a neutron quadrupole deformation parameter of $\beta_n$=0.46$\pm$0.21. This provides the first indication of a possible weakening of the $N$ = 8 shell closure at the proton drip-line.

The production of the p–nuclei is one of the unsolved puzzles in nuclear astrophysics. A possible mechanism is the nucleosynthesis in the neutrino–driven winds of core–collapse supernovae (νp–process), but it carries uncertainties, mostly in the supernova dynamics and the nuclear physics input. The pp-chain breakout reaction 7Be(α,γ)11C, which occurs prior to the supernova explosion, was identified as an important link which can influence the nuclear flow of the z/p-process and the final abundances of the p-nuclei. Nevertheless, its reaction rate is poorly known over the relevant energy range (T=1.5-3 GK). To improve the 7Be(α,γ)11C rate for vp-process nucleosynthesis temperatures, the first measurement of the strengths of two important resonances with unknown strength was recently performed at TRIUMF. A radioactive 7Be beam (t1/2 = 53.24 d) beam and the DRAGON recoil separator were used. The experimental details and preliminary results for the resonance strengths will be discussed.

International audience; The Cosmic Ray Energetics And Mass (CREAM) instrument on the International Space Station (ISS) is an experiment to study origin, propagation, acceleration and elemental composition of cosmic rays. The Top Counting Detector (TCD) and Bottom Counting Detector (BCD) are parts of the detector suite of the ISS-CREAM experiment and are designed to separate electrons and protons for studying electron and gamma-ray physics. In addition, the TCD/BCD provide a redundant trigger to that of the calorimeter and a low energy trigger to the ISS-CREAM instrument. After launching, the TCD/BCD trigger was found to be working well. Also, the TCD/BCD have been stable and their hit positions were confirmed to be well matched with other detectors on board. We present the performance and status of the TCD/BCD in flight.

International audience; The Cosmic Ray Energetics And Mass experiment for the International Space Station (ISS-CREAM) is a space-borne mission designed for the precision measurement of the energy and elemental composition of cosmic rays. The Silicon Charge Detector (SCD), placed at the top of the ISS-CREAM payload, consists of 4 layers. Each layer has 2688 silicon pixels and associated electronics arranged in such a fashion that its active detection area of 78.2 × 73.6 cm 2 is free of dead area. The foremost goal of the SCD is to efficiently and precisely measure the charge of cosmic rays passing through it. The 4-layer configuration was chosen to achieve the best precision in measuring the charge of cosmic rays within the constraints on the mass, volume and power allotted to it. The amount of material used for its support structure was minimized as well to reduce the chance of interactions of the cosmic ray within the structure. Given the placement of the SCD, its 4-layer configuration and the minimal amount of material in the cosmic-ray trajectory, the SCD is designed to measure the charge of cosmic rays ranging from protons to iron nuclei with excellent detection efficiency and charge resolution. We present the design and fabrication of the SCD as well as its performance during space environment tests which it underwent successfully. We also present its performance in charge measurement using heavy ions in a beam test at CERN, the European Organization for Nuclear Research.

The Cosmic Ray Energetics And Mass for the International Space Station (ISS-CREAM) instrument is a next-generation experiment for the direct detection and study of cosmic-ray nuclei and electrons. With a long exposure in low Earth orbit, the experiment will determine the particle fluxes and spectral details of cosmic-ray nuclei from hydrogen to iron, over an energy range of about 1 0 12 eV to > 1 0 15 eV, and of cosmic-ray electrons over an energy range of about 5 × 1 0 10 eV to > 1 0 13 eV. The instrument was deployed to the ISS in August 2017 on the SpaceX CRS-12 mission. We review the design, implementation and performance of one of the ISS-CREAM detector systems: a boron loaded scintillation detector used in discriminating electron-induced events from the much more abundant cosmic-ray nuclei.

Chinese rice noodles are a popular and traditional food item in southern China and have been a staple in the Chinese diet since ancient times. Various types of rice noodles are manufactured in several different shapes and are prepared from two basic ingredients: rice and water. The process for making rice noodles includes soaking, grinding, heating (steaming or boiling), molding (extruding or cutting), cooling, and drying. Classification of different types of rice noodles is based, in part, on the district in which they are produced and the production method used. For example, rice noodles are categorized as unfermented or fermented depending on the length of time the rice is soaked, which can last anywhere from several hours (short time) to several days (long time). Soaking is the main factor that affects the processing properties and quality characteristics of the final product. Natural fermentation occurs after the rice has been soaked for several days. Methods used to produce traditional Chinese foods...

International audience; The Cosmic Ray Energetics and Mass experiment at the International Space Station (ISS-CREAM) is developed for studying the origin, acceleration and propagation mechanism of high energy cosmic rays. The Top and Bottom Counting Detectors (TCD/BCD), sub-detectors of the ISS-CREAM instrument, are developed for electron/ γ -ray physics. The TCD/BCD help distinguish electrons from protons by comparing the hit and shower width distributions for electrons and protons. The e/p separation capability of the TCD/BCD is studied by using the GEANT3 simulation package, and optimal parameters for the e/p separation are obtained.

International audience; The Cosmic Ray Energetics And Mass experiment for the International Space Station (ISS-CREAM) is scheduled for launch in 2017. It is designed to directly measure and identify theelemental composition of incident Galactic cosmic rays from a few hundred GeV to PeV energies.Such large energy range sensitivity is reached by using an electromagnetic sampling calorimeter(CAL) which measures the energy deposit of particle-induced showers. The CAL is composedof twenty layers of tungsten plates interleaved with scintillating fibers, and glued together usingepoxy-coated fiberglass to comply with space launch requirements. In August 2015, beam testmeasurements were performed at CERN to verify the performance of the CAL using layers ofepoxy-coated fiberglass placed between tungsten plates. The CAL response to electron and pionbeams and its performance are reported and compared with previous beam test configurations.

International audience; The Cosmic Ray Energetics And Mass experiment for the International Space Station (ISS-CREAM) is a space-borne mission designed for the precision measurement of the energy and elemental composition of cosmic rays. It is scheduled to be launched and installed on the ISS in August 2017. The Silicon Charge Detector (SCD), placed at the top of the ISS-CREAM payload, consists of 4 layers. Each layer has 2688 silicon pixels and associated electronics arranged in such a fashion that its active detection area of 78 x 74 cm2 is free of any dead area. The foremost goal of the SCD is to efficiently and precisely measure the charge of cosmic rays passing through it. The 4-layer configuration was chosen to achieve the best precision in measuring the charge of cosmic rays within the constraints on the mass, volume and power allotted to it. The amount of material used for its support structure was minimized as well to reduce the chance of interactions of the cosmic ray within the structure. Given the placement of the SCD, its 4-layer configuration and the minimal amount of material in the cosmic-ray trajectory, the SCD is designed to measure the charge of cosmic rays ranging from protons to iron nuclei with excellent detection efficiency and charge resolution. We present the design and fabrication of the SCD. It successfully underwent space environment tests including vibration and thermal-vacuum qualification. We present the performance of the SCD during these tests, as well as its charge-measurement performance on the ground using cosmic muons and heavy ions in CERN beam tests.

International audience; The Cosmic-Ray Energetics And Mass (CREAM) instrument for the International Space Station (ISS) is a detector for studying the origin, acceleration and propagation mechanism of high-energy cosmic rays. The ISS-CREAM instrument is scheduled to launch in 2017 to the ISS. The Top and Bottom Counting Detectors (TCD/BCD) are designed for studying electron and gamma-ray physics. The TCD/BCD are composed of a plastic scintillator and an array of photodiodes The active detection areas of the TCD/BCD are 500 $\times$ 500 mm$^2$ and 600 $\times$ 600 mm$^2$, respectively. The TCD/BCD were completed in 2015 and passed the environmental tests for safety in a space environment. After finishing these tests, the TCD/BCD were integrated with the payload. The TCD is located between the carbon target of the ISS-CREAM instrument and the calorimeter, and the BCD is located below the calorimeter. The TCD/BCD can distinguish between electrons and protons by using the different shapes between electromagnetic and hadronic showers in the high-energy region. We study the TCD/BCD performance in various energy ranges by using GEANT3 simulation data. Here, we present the status of the electron and proton separation study with the TCD/BCD simulation.

International audience; The Cosmic Ray Energetics And Mass for the International Space Station (ISS-CREAM) instrument is designed and built to measure elemental spectra of cosmic-ray nuclei (1 ≤ Z ≤ 26) and electrons. It will measure energy of incident cosmic rays from 1011 to 10^15 eV with a tungsten/scintillator sampling calorimeter and densified carbon target with an interaction length of ~ 1 λL. A finely segmented, four-layer silicon charge detector will identify the elemental composition with a resolution of ~ 0.15e. The instrument is triggered by selectable, independent, and combined algorithms from the calorimeter and a scintillator-based counting detector on the top and bottom of the calorimeter. The counting detectors also provide separation of protons and electrons using differences in the shower shapes. A boronated scintillator detector provides additional e/p separation by looking at late scintillation light produced by a particle interacting in the calorimeter system. ISS-CREAM underwent vibrational, electromagnetic, thermal/vacuum, and telemetry systems tests at various NASA f acilities to qualify for rocket transportation and space operations. All testing and integration were completed and ISS-CREAM was delivered to NASA. It is now flight ready and waiting for launch on SpaceX-12 in 2017. ISS-CREAM integration, environmental qualification, and instrument performance will be presented.

Of particular interest in astrophysics is the $^{34}\mathrm{S}(p,\ensuremath{\gamma})^{35}\mathrm{Cl}$ reaction, which serves as a stepping stone in thermonuclear runaway reaction chains during a nova explosion. Though the isotopes involved are all stable, the reaction rate of this significant step is not well known, due to a lack of experimental spectroscopic information on states within the Gamow window above the proton separation threshold of $^{35}\mathrm{Cl}$. Measurements of level spins and parities provide input for the calculation of resonance strengths, which ultimately determine the astrophysical reaction rate of the $^{34}\mathrm{S}(p,\ensuremath{\gamma})^{35}\mathrm{Cl}$ proton capture reaction. By performing the $^{37}\mathrm{Cl}(p,t)^{35}\mathrm{Cl}$ reaction in normal kinematics at the Holifield Radioactive Ion Beam Facility at Oak Ridge National Laboratory, we have conducted a study of the region of astrophysical interest in $^{35}\mathrm{Cl}$, and have made the first-ever constraint on the spin and parity assignment for a level at $6677\ifmmode\pm\else\textpm\fi{}15$ keV $({E}_{r}=306$ keV), inside the Gamow window for novae.

We demonstrate an approach to measure the total fusion cross-section for beams of low-intensity light nuclei. Fusion residues resulting from the fusion of 20,16 O+ 12 C are directly measured and distinguished from unreacted beam particles on the basis of their energy and time-of-flight. The time-of-flight is measured between a microchannel plate (MCP) detector, which serves as a start, and a segmented silicon detector, which provides a stop. The two main difficulties associated with the initial implementation of this approach are charge trapping in the silicon detector and slit scattering in the MCP detector. Both these obstacles have been characterized and overcome. To reduce atomic slit scattering in the measurement we have eliminated wires from the beam path by developing a gridless MCP detector. The total fusion cross-section for 16 O+ 12 C in the energy range E CM =8.0–12.0 MeV has been measured in agreement with established literature values (down to the 100 mb level).

The time dependence of the relative light emission of Eljen Technology EJ-200 polyvinyltoluene-based plastic scintillator was measured between 1 and 10 μ s after the passage of a particle shower, a singly charged particle (atmospheric muon), and with a UV LED exciting the fluor. This was compared in magnitude to the integrated response for the prompt light (within 500 ns of excitation). A model with a time-dependent yield consisting of three exponentially decaying components (fast, medium, and slow) was developed to fit the data. Note that the exact time structure of early ( 1 μ s ) light emission was not measured for individual components, only for all three components together This model assumes all three components share the same rise time. The decay time constants of the fast, medium and slow components are, respectively, 7.8 ns, 490 ns, and 2370 ns. The relative total normalized yields for each component are: fast 95.8%, medium 2.2%, and slow 2.0%.

International audience; The Boron And Carbon Cosmic rays in the Upper Stratosphere (BACCUS) balloon-borne exper-iment flew for 30 days over Antarctica in December 2016. It is the successor of the CREAMballoon program in Antarctica which recorded a total cumulative exposure of 161 days. BAC-CUS is primarily aimed to measure cosmic-ray boron and carbon fluxes at the highest energiesreachable with a balloon or satellite experiment, in order to provide essential information for abetter understanding of cosmic-ray propagation in the Galaxy. The payload is made of multipleparticle physics detectors which measure the charge up to Z=26 and energy of incident particlesfrom a few hundred GeV to a few PeV. The newly designed Transition Radiation Detector (TRD)measures signals that are a function of the charge and Lorentz factor. In April 2016, BACCUSwas taken to CERN in its flight configuration to characterize its detectors’ response to beams ofelectrons and pions. The performance of the TRD using beam test data are reported in this paper.

In this study, the presence of neutron transfer channels with positive Q values can enhance sub-barrier fusion cross sections. Recent measurements of the fusion excitation functions for 58Ni+132,124Sn found that the fusion enhancement due to the influence of neutron transfer is smaller than that in 40Ca +132,124Sn although the Q values for multineutron transfer are comparable. The purpose of this study is to investigate the differences observed between the fusion of Sn + Ni and Sn + Ca. Methods: Fusion excitation functions for 46,50Ti +124Sn have been measured at energies near the Coulomb barrier. As a result, a comparison of the barrier distributions for 46Ti+124Sn and 40Ca+124Sn shows that the 40Ca+124Sn system has a barrier strength resulting from the coupling to the very collective octupole state in 40Ca at an energy significantly lower than the uncoupled barrier. In conclusion, the large sub-barrier fusion enhancement in 40Ca induced reactions is attributed to both couplings to neutron transfer and inelastic excitation, with the octupole vibration of 40Ca playing a major role.

To investigate the expression of hepatocyte growth factor (HGF) and its relationship with microsatellite instability (MSI) and their influence on survival in patients with colorectal cancer.Immunohistochemistry (IHC) was used to detect the expression of HGF and MSI in 98 specimens of colorectal cancer. Tumors lacking protein expression of any of the four mismatch repair genes (MLH1, PMS2, MSH2 or MSH6) were labelled as MSI, and the rest were considered as microsatellite stable (MSS). The associations between expression and clinicopathological factors were assessed using Chi-square tests. Kaplan-Meier curves, log-rank test, and Cox regression were used to analyze the association between biomarker expressions and overall survival.The incidence rate of MSI in 98 colorectal specimens was 32.7%, and was statistically significantly correlated with the location of tumor and differentiation degree (P0.05). The HGF-expression rate was 71.4%. The patients with an MSI tumor had a significantly higher HGF expression, compared with the patients with an MSS tumor (P=0.048). The 5-year survival rate of MSI group and MSS group were 39.8% and 58.7%, respectively (P=0.009). The 5-year survival rate of HGF-positive group and HGF-negative group were 46.2% and 67.9% (P=0.035). The multivariate analysis showed that lymphocytic infiltration, TMN stage, MSI and HGF are independent prognostic factors in colorectal cancer (P0.05 for all).HGF is highly expressed in colorectal cancer patients with microsatellite instability. Both microsatellite instability and HGF are independent factors affecting the prognosis in patient with colorectal cancer.

The use of neutron-rich radioactive isotope beams for synthesizing heavy elements is a subject of continuing interest. Current experiments utilize low intensity beams to study reaction mechanisms for fusion induced by neutron-rich radioactive nuclei. Enhanced fusion cross sections were observed near and below the Coulomb barrier. A lowering of the barrier height was observed for heavy mass compound systems. Future experiments will benefit from improving detectors and increasing beam intensities.

Angular distributions of the Coulomb breakup of radioactive 17F were measured by impinging a 10 MeV/nucleon beam on 208Pb and on 58Ni to study the dynamic polarization effects. The breakup products, oxygen and a proton, were detected in coincidence. First-order perturbation theory significantly overpredicts the breakup cross section for the 208Pb target. Dynamical calculations with a dynamic polarization as the leading order correction were performed. The calculations reproduce the data for 17F on 58Ni but overpredict the breakup of 17F on 208Pb by a factor of two at forward angles.

A renewed interest in Accelerator Mass Spectrometry (AMS) from nuclear physics laboratories is emerging in connection with Radioactive Ion Beams (RIBs). At the Holifield Radioactive Ion Beam Facility (HRIBF) at Oak Ridge National Laboratory (ORNL) we are exploring the AMS capabilities of the 25-MV tandem accelerator. Behind this effort is the realization that two fields of research – AMS and RIBs – complement each other in techniques. Development of effective and efficient beam purification techniques is of common interest to both AMS and the RIB program. Two main characteristics of the 25-MV tandem provide unique opportunities for performing the highest sensitivity measurements of AMS; namely (i) the highest operating voltage in the world, and (ii) a folded geometry which involves a 180° magnet in the terminal. For the RIB program, we have used AMS techniques to improve the sensitivity of detection of some radioactive species in the measurement of unknown masses of n-rich nuclei. For AMS, we have concentrated in exploring two important isotopes, 14C and 36Cl, for applications that require the highest sensitivity. We have successfully measured 36Cl/Cl ratios as low as a few times 10−16 in seawater samples demonstrating that our setup has the highest sensitivity for this isotope and proving that 36Cl can be measured at the levels required for a tracer in oceanography.

Beams of 132,134 Sn and 134 Te were used to bombard a 64 Ni target and measure fusion excitation functions near the Coulomb barrier. Fusion induced by 132,134 Sn and 134 Te below the barrier is enhanced as compared to stable Sn and Te beams. The enhancement in 132 Sn and 134 Te is essentially due to the larger radii which lower the Coulomb barriers. However, the enhancement in 134 Sn induced fusion cannot be accounted for by the change in nuclear size.

A gas-filled RF quadrupole ion beam cooler has been significantly improved for cooling negative ion beams. Electron detachment plays a significant role in determining the transmission of negative ions. It has been suggested that collisions with the residual buffer gas in the deceleration and injection region of the ion beam cooler, where the ions still possess relatively large energies, could result in substantial losses in negative ions due to electron detachment. The ion beam cooler is modified to improve the pumping conductance in the quadrupole entrance region for effectively removing the buffer gas and minimizing the residual gas escaping to the deceleration and injection region. This significantly reduces the collisions encountered by the ions before they are retarded to energies below the threshold for electron detachment. Overall transmission efficiencies of more than 50% have been obtained with the modified cooler for some negative ions.

A complete set of electromagnetic moments, B(E2;0+1 2+1), Q(2+1), and g(2+1), have been measured from Coulomb excitation of semi-magic 112,114,116,118,120,122,124Sn (Z = 50) on natural carbon and titanium targets. The magnitude of the B(E2) values, measured to a precision of ~4%, disagree with a recent lifetime study [Phys. Lett. B 695, 110 (2011)] that employed the Doppler- shift attenuation method. The B(E2) values show an overall enhancement compared with recent theoretical calculations and a clear asymmetry about midshell, contrary to naive expectations. A new static electric quadrupole moment, Q(2+1), has been measured for 114Sn. The static quadrupole moments are generally consistent with zero but reveal an enhancement near midshell; this had not been previously observed. The magnetic dipole moments are consistent with previous measurements and show a near monotonic decrease in value with neutron number. The current theory calculations fail to reproduce the electromagnetic moments of the tin isotopes. The role of 2p-2h and 4p-4h intruders, which are lowest in energy at mid shell and outside of current model spaces, needs to be investigated in the future.

The Galactic 1.809-MeV $\ensuremath{\gamma}$-ray signature from the $\ensuremath{\beta}$ decay of $^{26g}\mathrm{Al}$ is a dominant target of $\ensuremath{\gamma}$-ray astronomy, of which a significant component is understood to originate from massive stars. The $^{26g}\mathrm{Al}(p,\ensuremath{\gamma})^{27}\mathrm{Si}$ reaction is a major destruction pathway for $^{26g}\mathrm{Al}$ at stellar temperatures, but the reaction rate is poorly constrained due to uncertainties in the strengths of low-lying resonances in $^{27}\mathrm{Si}$. The $^{26g}\mathrm{Al}(d,p)^{27}\mathrm{Al}$ reaction has been employed in inverse kinematics to determine the spectroscopic factors, and hence resonance strengths, of proton resonances in $^{27}\mathrm{Si}$ via mirror symmetry. The strength of the 127-keV resonance is found to be a factor of 4 higher than the previously adopted upper limit, and the upper limit for the 68-keV resonance has been reduced by an order of magnitude, considerably constraining the $^{26g}\mathrm{Al}$ destruction rate at stellar temperatures.

International audience; The Galactic 1.809-MeV γ-ray signature from the β decay of $^{26g}$Al is a dominant target of γ-rayastronomy, of which a significant component is understood to originate from massive stars. The$^{26g}$Al(p; γ)$^{27}$Si reaction is a major destruction pathway for $^{26g}$Al at stellar temperatures, but the reactionrate is poorly constrained due to uncertainties in the strengths of low-lying resonances in $^{27}$Si. The$^{26g}$Al(d; p)$^{27}$Al reaction has been employed in inverse kinematics to determine the spectroscopic factors,and hence resonance strengths, of proton resonances in $^{27}$Si via mirror symmetry. The strength of the127-keV resonance is found to be a factor of 4 higher than the previously adopted upper limit, and the upperlimit for the 68-keV resonance has been reduced by an order of magnitude, considerably constraining the$^{26g}$Al destruction rate at stellar temperatures.

A technique for measuring mass differences has been developed at the Holifield Radioactive Ion Beam Facility (HRIBF) that requires no specialized equipment. Mass differences are measured as position differences between known and unknown-mass isobars, dispersed at the image of the energy-analyzing magnet following the 25 MV tandem post-accelerator, and identified by an energy-loss measurement. The technique has been demonstrated on neutron-rich 77–79Cu and 83–86Ge isotopes produced using the isotope separator online (ISOL) method with the 238U(p,fission) reaction, where a mass accuracy of 500 keV was achieved. These nuclides are well suited to the measurement technique, as they readily migrate out of the production target and to the ion source and comprise the most neutron-rich elements of the isobarically mixed beam. Because modest precision mass values can be obtained with only a few tens of counts of the nuclide of interest among orders of magnitude more of the isobaric neighbors closer to stability, the sensitivity of this technique makes it appropriate for initial mass measurements far from stability.

Initial measurements are presented of the (d,p) reactions on neutron-rich N = 50 isotones along the r-process path of nucleosynthesis with radioactive ion beams of 82Ge and 84Se. Prospects for measurements with unstable 130,132Sn beams are discussed.

A setup for measuring cross-sections of evaporation residues produced in the collision of two heavy ions is described. The system, which detects all reaction products in a narrow angular range around the beam direction, is designed to work best with low-intensity beams ( ⩽ 10 5 ions / s ) and can be highly efficient for reactions studied in inverse kinematic conditions, i.e., heavy-mass beam on lighter-mass targets. The system as presented here has been optimized to study evaporation residues from reactions induced by radioactive ion beams with charges near Z ∼ 50 and energies near 4 MeV/nucleon. Continuous sampling of the beam velocity, energy loss and position allow for the measurement of accurate evaporation residue cross-sections also in situations where the beam contains a mixture nuclides.

Neutron-rich radioactive ion beams available from the HRIBF allow a variety of measurements around the 132Sn region, including Coulomb excitation and single-nucleon transfer. The B(E2;0+ → 2+) values for first 2+ excited states of even-even neutron-rich 132-136Te and 126-130Sn have been measured by Coulomb excitation in inverse kinematics. Neutron transfer onto a 134Te beam from 9Be and 13C targets, to populate single-particle states in 135Te, has also been studied. Gamma rays from the 13C(134Te, 12C) reaction were used to identify the νi13/2 state in 135Te, at an energy of 2109 keV. These and other results, and plans for future experiments with these neutron-rich beams, are presented.

Single-neutron transfer reactions have been measured on two N = 50 isotones at the Holifield Radioactive Ion Beam Facility (HRIBF). The single-particle-like states of 83Ge and 85Se have been populated using radioactive ion beams of 82Ge and 84Se and the (d, p) reaction in inverse kinematics. The properties of the lowest-lying states —including excitation energies, orbital angular momenta, and spectroscopic factors— have been determined for these N = 51 nuclei.

We describe an experiment optimized to determine the transition probabilities for excitation of the first excited 2+ state in 132Sn. The large excitation energy (4.04 MeV) and consequent small excitation cross-section, together with the modest beam intensity available makes this a challenging experiment. The preliminary result is B(E2; 0+ → 2+) = 0.11 ± 0.03e 2 b 2. The high efficiency and generalized nature of the setup enabled us to also measure the first 2+ state in the two-neutron nucleus 134Sn. We have determined a value of B(E2; 0+ → 2+) = 0.029 ± 0.005e 2 b 2 which shows no sign of the asymmetry with respect to the N = 82 shell closure exhibited by the Te isotopes.

The rates of the 18 F( p , α ) 15 O and 18 F( p , γ ) 19 Ne reactions in astrophysical environments depend on the properties of 19 Ne levels above the 18 F + p threshold. There are at least 8 levels in the mirror nucleus 19 F for which analogs have not been observed in 19 Ne in the excitation energy range E x = 6.4 – 7.6 MeV . These levels may significantly enhance the 18 F + p reaction rates, and thus we have made a search for these levels by measuring the 1 H( 18 F, p ) 18 F excitation function over the energy range E c . m . = 0.3 - 1.3 MeV . We have identified and measured the properties of a newly observed level at E x = 7.420 ± 0.014 MeV , which is most likely the mirror to the J π = 7 2 + 19 F level at 7.56 MeV. We have additionally found a significant discrepancy with a recent compilation for the properties of a 19 Ne state at E x = 7.5 MeV and set upper limits on the proton widths of missing levels.

Neutron-rich radioactive ion beams available from the HRIBF allow a variety of measurements around the 132Sn region, including Coulomb excitation, fusion-evaporation, and neutron transfer. The B ( E 2 ; 0 + → 2 + ) value for first 2+ excited states of even-even neutron-rich 132–136Te and 126–134Sn have been measured by Coulomb excitation in inverse kinematics. The results are discussed in terms of the shell model and the quasiparticle random phase approximation. Neutron transfer onto a 134Te beam, from 9Be and 13C targets to populate single-particle states in 135Te, has also been studied. Gamma rays from the 13C(134Te, 12C) reaction were used to identify the ν i 13 / 2 state in 135Te, at an energy of 2109 keV. These and other results, and plans for future experiments with these neutron-rich beams, are presented.